Erius in tablets

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Erius

Instructions for use:

Prices in online pharmacies:

Erius is an antiallergic drug, a blocker of histamine H1 receptors.

The drug is presented in the form of round tablets coated with a blue coating and a transparent orange syrup.

Table of contents:

The active ingredient of Erius is desloratadine. Auxiliary components of tablets are microcrystalline cellulose, calcium hydrogen phosphate dihydrate, corn starch, talc.

Excipients of Erius syrup - sorbitol, propylene glycol, anhydrous citric acid, sodium benzoate, sodium citrate dihydrate, disodium edetate, flavor No. 15864, sucrose, dye, purified water.

pharmachologic effect

Erius is an antihistamine - a drug that blocks histamine receptors in the body, which leads to inhibition of allergic reactions. The active substance of Erius selectively acts on neurotransmitters that influence the blistering-hyperemic reaction of the skin, itching, etc., without penetrating the blood-brain barrier. Research has proven that the use of Erius can suppress the following body reactions:

  • Production of pro-inflammatory chemokines and cytokines;
  • Eosinophilic granulocyte adhesion and chemotaxis;
  • IgE-dependent release of histamine, prostaglandin D2 and leukotriene C4;
  • Increased adhesiveness of P-selectin;
  • Development of acute bronchospasm-atopic nature (in experiments involving animals).

The drug has antipruritic, antiallergic and antiexudative effects, preventing the occurrence and easing the course of allergic reactions. Erius effectively relieves spasms of smooth muscles and prevents the appearance of tissue swelling.

Reviews of Erius do not note the appearance of a pronounced sedative (calming) effect. In addition, clinical studies have shown that taking Erius at a dosage of 20 mg/day for 2 weeks does not have a significant effect on the functioning of the cardiovascular system. Unlike other antihistamines, the effectiveness of Erius is not affected by the consumption of fatty foods or grapefruit juice.

Indications for use of Erius

According to the instructions, Erius is effective against diseases such as:

  • Allergic rhinitis (including intermittent and persistent);
  • Hay fever, intended for quick relief (elimination of painful phenomena) itching in the eyes, sneezing, lacrimation, coughing, swelling of the nasal mucosa, conjunctival hyperemia;
  • Chronic idiopathic urticaria.

Contraindications

The use of Erius is not recommended for persons who are hypersensitive to desloratadine and other components included in the drug. In addition, it is not recommended to take Erius if you have congenital fructose intolerance or the presence of diseases associated with impaired absorption of galactose or glucose - due to the presence of these substances in Erius syrup.

At the moment, the safety profile of Erius for pregnant women has not been established, so taking the drug by women expecting a child is not recommended. It has been clinically discovered that the active substance of the drug passes into breast milk, so breastfeeding should be stopped while taking Erius.

Erius should be used with caution in patients suffering from severe renal failure.

Side effects of Erius

Side effects of Erius and analogues of the drug include increased fatigue, dry mouth, headache, tachycardia, allergic reactions (anaphylactic shock, rash), hepatitis, increased activity of liver enzymes, increased bilirubin in the blood. In reviews of Erius, cases of insomnia, diarrhea and chills were noted when taking the drug by children under 2 years of age.

How to use Erius

The optimal dosage of Erius according to the instructions for adults and adolescents from 12 years of age is 5 mg per day. It is not recommended to break the tablet; the medicine is taken whole with a small amount of liquid. Dosage for children from 2-5 years: 2.5 ml of syrup, for children from 6-11 years: 5 ml of syrup.

Overdose

If the dosage of the drug is exceeded, it is recommended to carry out standard measures to remove desloratadine from the gastrointestinal tract (taking activated charcoal, gastric lavage) and carry out symptomatic therapy. The drug is not eliminated by hemodialysis. According to specialist research, an overdose of the drug by 9 times does not have a serious negative effect on the body.

Analogues of the drug

Analogues of Erius (substitute drugs) are such drugs as Desloratadine, Desloratadinagemisulfate, Lordestin.

Other information

Eating at the same time as taking Erius does not have a significant effect on the effectiveness of the drug.

According to the instructions, Erius also does not have an adverse effect on people driving vehicles.

Erius syrup 0.5 mg/ml 60 ml

Erius tablets 5 mg 10 pcs.

Erius tablets 5 mg 10 pcs.

Erius syrup 60ml

Erius syrup 2.5mg/5ml 60ml

Erius tab. p.p.o. 5mg n10

Erius syrup 60 ml

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Source: http://www.neboleem.net/jerius.php

Erius tablets - official instructions for use

on the use of the drug

for medical use

Registration number:

Tradename:

International nonproprietary name:

Dosage form:

Compound

One lozenge contains:

active ingredients: desloratadine coated granules 21.93 mg*;

excipients: red iron oxide dye 0.43 mg, aspartame 2.55 mg, colloidal silicon dioxide 0.25 mg, crospovidone 8.50 mg, microcrystalline cellulose** 5.00 mg, sodium bicarbonate 2.12 mg, citric acid 1.28 mg, granulated mannitol 29 mg, magnesium stearate 1.70 mg, mannitol 24.44 mg*, fruit flavor 0.51 mg.

21.93 mg of coated granules contain:

active substance: desloratadine, crushed 2.50 mg;

excipients: microcrystalline cellulose 9.99 mg, mannitol 2.50 mg, pregelatinized starch 0.95 mg, sodium carboxymethyl starch 0.50 mg, butyl methacrylate, dimethylaminoethyl methacrylate and methyl methacrylate copolymer (1:2:1) 3.65 mg, magnesium stearate 1.82 mg, purified water (used in the preparation of sodium carboxymethyl starch), alcohol SDA-3A anhydrous (used to prepare the coating and removed during the coating process).

One lozenge contains:

active ingredients: desloratadine coated granules 43.86 mg*;

excipients: red iron oxide dye 0.86 mg, aspartame 5.10 mg, colloidal silicon dioxide 0.50 mg, crospovidone 17.00 mg, microcrystalline cellulose** 10.00 mg, sodium bicarbonate 4.24 mg, citric acid 2.56 mg, granulated mannitol 58 mg, magnesium stearate 3.40 mg, mannitol 48.88 mg*, fruit flavor 1.02 mg.

43.68 mg of coated granule contains:

active substance: desloratadine, crushed 5.00 mg;

excipients: microcrystalline cellulose 19.99 mg, mannitol 5.00 mg, pregelatinized starch 1.90 mg, sodium carboxymethyl starch 1.00 mg, butyl methacrylate, dimethylaminoethyl methacrylate and methyl methacrylate copolymer (1:2:1) 7.31 mg, magnesium stearate 3.65 mg, purified water (used in the preparation of sodium carboxymethyl starch), alcohol SDA-3A anhydrous (used to obtain the coating and removed during the coating process).

* - the amount per tablet depends on the content of the active substance in the film-coated granules of desloratadine;

** - with low humidity.

Dosage 2.5 mg

Round, flat-cylindrical, light red tablets interspersed with beveled edges and the inscription “K”, applied by embossing, on one side.

Round, flat cylindrical, light red tablets interspersed with beveled edges and embossed with the inscription “A” on one side.

Pharmacotherapeutic group

Pharmacological properties

Long-acting non-sedating antihistamine. It is the primary active metabolite of loratadine. Selectively blocks the activity of peripheral H1 histamine receptors. Suppresses the release of histamine from mast cells. Inhibits the cascade of allergic inflammation reactions, including the release of pro-inflammatory cytokines, including interleukins IL-4, IL-6, IL-8, IL-13, and the release of adhesion molecules such as P-selectin. Thus, it prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative effects, reduces capillary permeability, and prevents the development of tissue edema and smooth muscle spasm.

The drug has no effect on the central nervous system, does not cause drowsiness (the use of desloratadine at the recommended dose of 5 mg per day is not accompanied by an increase in the incidence of drowsiness compared to the placebo group) and does not affect the speed of psychomotor reactions. Does not cause prolongation of the QT interval on the ECG.

Desloratadine is well absorbed from the gastrointestinal tract. Determined in blood plasma 30 minutes after oral administration. The maximum concentration is reached on average 3 hours after administration. Does not penetrate the blood-brain barrier. Communication with plasma proteins is 83-87%. When used in adults and adolescents for 14 days at a dose of 5 mg to 20 mg once a day, no clinically significant accumulation of the drug was observed. Concomitant ingestion of food or grapefruit juice does not affect the distribution of desloratadine when used at a dose of 7.5 mg once daily. Desloratadine is not an inhibitor of CYP3A4 or CYP2D6 isoenzymes and is not a substrate or inhibitor of P-glycoprotein. Intensively metabolized in the liver by hydroxylation to form 3-OH-desloratadine combined with a glucuronide. Only a small part of the dose taken orally is excreted unchanged by the kidneys (<2%) and intestines (<7%). The half-life is an average of 27 hours. Based on single-dose, crossover studies, desloratadine 5 mg lozenge and conventional 5 mg tablet formulations are bioequivalent. The effectiveness of desloratadine 2.5 mg tablets has not been studied in pediatric patients. However, pharmacokinetic data obtained from a dose-finding study in pediatric patients demonstrate the feasibility of desloratadine 2.5 mg lozenges in children aged 6 to 11 years.

Water does not affect the bioavailability of the drug Erius ® lozenges.

Indications for use

Contraindications

In the presence of severe renal failure, Erius ® should be used with caution.

Each dose of the drug containing 5 mg of the active substance contains 2.9 mg of phenylalanine. Phenylalanine may cause unwanted effects in patients with phenylketonuria.

Directions for use and doses

Adults and adolescents 12 years of age and older: One 5 mg lozenge once daily to reduce symptoms of allergic rhinitis (including seasonal and perennial allergic rhinitis) and urticaria.

Children ages 6 to 11 years: One 2.5 mg lozenge once daily to reduce symptoms of allergic rhinitis (including seasonal and perennial allergic rhinitis) and urticaria.

For seasonal (intermittent) allergic rhinitis (symptoms lasting less than 4 days a week or less than 4 weeks a year), the course of the disease must be assessed. If symptoms disappear, the drug should be stopped; if symptoms reappear, the drug should be resumed.

For year-round (persistent) allergic rhinitis (if symptoms last more than 4 days a week or more than 4 weeks a year), the drug should be taken throughout the entire period of allergen exposure.

Side effect

Very rarely (<1/10,000) the following undesirable effects were observed:

  • from the nervous system: hallucinations, dizziness, drowsiness, insomnia, psychomotor hyperactivity, convulsions;
  • from the liver and biliary tract: increased activity of liver enzymes, bilirubin concentration, hepatitis;
  • from the digestive system: abdominal pain, nausea, vomiting, dyspepsia, diarrhea;
  • from the cardiovascular system: tachycardia, palpitations;
  • from the musculoskeletal system: myalgia;
  • allergic reactions: anaphylaxis, angioedema, shortness of breath, itching, rash, including urticaria.

    Overdose

    In a clinical pharmacological study, when using desloratadine at a dose of up to 45 mg (9 times higher than the therapeutic dose), no clinically significant adverse effects were observed.

    Desloratadine is not removed by hemodialysis. There are no data on its elimination during peritoneal dialysis.

    Information regarding acute overdose is limited to post-marketing reports of adverse events and data from pre-marketing clinical studies. In a dose-finding study, drowsiness was reported with desloratadine 10 mg and 20 mg daily. Interaction with other drugs Interactions with other drugs were not detected in studies with azithromycin, ketoconazole, erythromycin, fluoxetine and cimetidine. Eating does not affect the effectiveness of the drug. Erius ® does not enhance the effect of alcohol on the central nervous system.

    Use during pregnancy and breastfeeding

    Desloratadine is excreted into breast milk, therefore the use of the drug Erius ® during breastfeeding is contraindicated. Effect on the ability to drive vehicles and operate machinery Desloratadine does not affect the ability to drive vehicles and operate machinery.

    However, in very rare cases, some patients experience drowsiness while taking the drug, which may affect their ability to drive or operate machines.

    Release form

    1,2, 3, 4, 5, 6, 10, 12, 15, 18 or 20 blisters per cardboard box along with instructions for use.

    Storage conditions

    Keep out of the reach of children.

    Best before date

    Do not use after expiration date.

    Vacation conditions

    Schering Plau Labo N.V., Heist op den Berg, Belgium

    Manufacturer

    Sima Labe Inc., Prairie Ideas, USA CIMA LABS INC.Valley View Road, Eden Prairie, MN 55344, USA Release quality control:

    Schering-Plough Labo N.V., Heist-op-den-Berg, Belgium Schering-Plough Labo N.V., Industriepark 30, B-2220, Heist-op-den-Berg, Belgium Send consumer complaints to:

    LLC "MSD Pharmaceuticals" st. Pavlovskaya, 7, building 1, Moscow, Russia.

    Source: http://medi.ru/instrukciya/erius-tabletki_3250/

    Erius - instructions for use, reviews, analogs and release forms (syrup or drops, 5 mg and 2.5 mg lozenges) medications for the treatment of urticaria and allergic rhinitis in adults, children and pregnancy. Compound

    In this article you can read the instructions for using the drug Erius. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Erius in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Erius in the presence of existing structural analogues. Use for the treatment of urticaria and allergic rhinitis in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

    Erius is a long-acting antihistamine, a blocker of peripheral histamine H1 receptors. Desloratadine is the primary active metabolite of loratadine. Inhibits the cascade of allergic inflammation reactions, incl. release of proinflammatory cytokines, including interleukins IL-4, IL-6, IL-8, IL-13, release of proinflammatory chemokines, production of superoxide anions by activated polymorphonuclear neutrophils, adhesion and chemotaxis of eosinophils, release of adhesion molecules such as P-selectin, IgE - mediated release of histamine, prostaglandin D2 and leukotriene C4. Thus, it prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative effects, reduces capillary permeability, and prevents the development of tissue edema and smooth muscle spasm.

    The drug has no effect on the central nervous system, has virtually no sedative effect (does not cause drowsiness) and does not affect the speed of psychomotor reactions.

    Does not cause prolongation of the QT interval on the ECG.

    The action of Erius begins within 30 minutes after oral administration and continues for 24 hours.

    Desloratadine + excipients.

    After taking the drug orally, Erius is well absorbed from the gastrointestinal tract. Concomitant food intake or concomitant consumption of grapefruit juice does not affect the distribution of desloratadine. Does not penetrate the blood-brain barrier (BBB). Desloratadine is excreted from the body as a glucuronide compound and in small amounts (less than 2% in urine and less than 7% in feces) unchanged.

    • allergic rhinitis (elimination or relief of sneezing, nasal congestion, nasal mucus, itchy nose, itchy palate, itching and redness of the eyes, watery eyes);
    • urticaria (reduction or elimination of skin itching, rash).

    Film-coated tablets 5 mg.

    Lozenges 2.5 mg and 5 mg.

    Syrup (ideal children's form of the drug).

    Other forms, be it drops, spray or ointment, did not exist at the time of publication in the directory.

    Instructions for use and dosage

    Adults and adolescents aged 12 years and older are prescribed 5 mg 1 time per day, regardless of meals, preferably at the same time of day.

    The tablet should be swallowed whole, without chewing, with a small amount of water.

    Children aged 1 to 5 years are prescribed 1.25 mg (2.5 ml of syrup) 1 time per day; children aged 6 to 11 years - 2.5 mg (5 ml syrup) 1 time per day; adults and adolescents over 12 years old - 5 mg (10 ml syrup) 1 time per day.

    The syrup is taken orally, regardless of food intake, with a small amount of water.

    • fatigue;
    • dry mouth;
    • headache;
    • dizziness;
    • tachycardia;
    • heartbeat;
    • anaphylaxis;
    • angioedema;
    • itching;
    • hives;
    • rash;
    • nausea, vomiting;
    • diarrhea;
    • increased body temperature;
    • insomnia.
    • pregnancy;
    • lactation (breastfeeding);
    • age up to 1 year (for syrup);
    • age up to 12 years (for film-coated tablets);
    • hereditarily transmitted diseases (fructose intolerance, glucose/galactose malabsorption or sucrase/isomaltase deficiency in the body) due to the presence of sucrose and sorbitol in the syrup;
    • hypersensitivity to the components of the drug.

    Use during pregnancy and breastfeeding

    The use of the drug during pregnancy is not recommended due to the lack of clinical data on the safety of its use during this period.

    Desloratadine is excreted in breast milk, so the use of Erius during breastfeeding is not recommended.

    The effectiveness and safety of using Erius in syrup form in children under 1 year of age has not been established.

    In most cases, rhinitis in children under 2 years of age is infectious in nature. There have been no studies of the effectiveness of Erius for rhinitis of infectious etiology.

    Differential diagnosis between allergic rhinitis and rhinitis of other origin in children under 2 years of age presents certain difficulties. When making a differential diagnosis, attention should be paid to the presence or absence of foci of infection or structural abnormalities of the upper respiratory tract, a thorough history, examination, and appropriate laboratory tests and skin tests.

    Eating does not affect the effectiveness of the drug.

    Impact on the ability to drive a car and operate machinery

    At the recommended dose, Erius does not affect the ability to drive vehicles or operate machinery.

    Erius does not enhance the effects of ethanol (alcohol) on the central nervous system.

    No clinically significant interactions with other drugs have been identified.

    Analogues of the drug Erius

    Structural analogues of the active substance:

    Source: http://instrukciya-otzyvy.ru/390-erius-po-primeneniyu-analogi-sirop-kapli-tabletki-krapivnica-rinit-sostav.html

    ERIUS

    ◊ film-coated tablets , round, biconvex, embossed with the Schering-Plough trademark in the form of the stylized letters “SP” on one side.

    Excipients: calcium hydrogen phosphate dihydrate - 53 mg, microcrystalline cellulose - 28 mg, corn starch - 11 mg, talc - 3 mg.

    Shell composition: opadry blue (lactose monohydrate, hypromellose, titanium dioxide, macrogol, aluminum blue varnish) - 6 mg; opadry transparent (hypromellose, macrogol) - 0.6 mg, carnauba wax - 0.005 mg, white beeswax - 0.005 mg.

    7 pcs. - blisters (1) - cardboard packs.

    10 pieces. - blisters (1) - cardboard packs.

    ◊ Orange syrup

    Excipients: propylene glycol mg, sorbitol mg, citric acid mg, sodium citrate dihydrate - 1.26 mg, sodium benzoate - 1 mg, disodium edetat mg, sucrose, flavoring No. mkg, sunset yellow dye - 23 mcg, purified water - up to 1 ml.

    60 ml - dark glass bottles (1) complete with a dosage spoon, graduated to 2.5 ml - cardboard packs.

    120 ml - dark glass bottles (1) complete with a dosing spoon, graduated to 2.5 ml - cardboard packs.

    Long-acting antihistamine, blocker of peripheral histamine H1 receptors . Desloratadine is the primary active metabolite of loratadine. Inhibits the cascade of allergic inflammation reactions, incl. release of proinflammatory cytokines, including interleukins IL-4, IL-6, IL-8, IL-13, release of proinflammatory chemokines, production of superoxide anions by activated polymorphonuclear neutrophils, adhesion and chemotaxis of eosinophils, release of adhesion molecules such as P-selectin, IgE - mediated release of histamine, prostaglandin D2 and leukotriene C4 . Thus, it prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative effects, reduces capillary permeability, and prevents the development of tissue edema and smooth muscle spasm.

    The drug has no effect on the central nervous system, has virtually no sedative effect (does not cause drowsiness) and does not affect the speed of psychomotor reactions.

    Does not cause prolongation of the QT interval on the ECG.

    The effect of the drug Erius begins within 30 minutes after oral administration and continues for 24 hours.

    After taking the drug orally, desloratadine is well absorbed from the gastrointestinal tract, with detectable concentrations of desloratadine in the blood plasma achieved within 30 minutes, and Cmax after approximately 3 hours.

    The binding of desloratadine to plasma proteins is 83-87%. When used in adults and adolescents for 14 days at a dose of 5 mg to 20 mg 1 time / day, no signs of clinically significant accumulation of desloratadine were detected. Simultaneous food intake or simultaneous consumption of grapefruit juice does not affect the distribution of desloratadine (when taken at a dose of 7.5 mg 1 time / day). Does not penetrate the BBB.

    It is extensively metabolized by hydroxylation to form 3-OH-desloratadine combined with a glucuronide. It is not an inhibitor of CYP3A4 or CYP2D6 and is not a substrate or inhibitor of P-glycoprotein.

    Desloratadine is excreted from the body as a glucuronide compound, and only a small portion is excreted unchanged by the kidneys (<2%) and intestines (<7%).

    T 1/2 averages 27 hours.

    - allergic rhinitis (elimination or relief of sneezing, nasal congestion, nasal mucus, itching of the nose, itching of the palate, itching and redness of the eyes, watery eyes);

    - urticaria (reduction or elimination of skin itching, rash).

    - lactation (breastfeeding);

    - age up to 1 year (for syrup);

    - age up to 12 years (for film-coated tablets);

    - hereditarily transmitted diseases (fructose intolerance, glucose/galactose malabsorption or sucrase/isomaltase deficiency in the body) due to the presence of sucrose and sorbitol in the syrup;

    - hypersensitivity to the components of the drug.

    with caution in severe renal failure.

    Film-coated tablets

    Adults and adolescents aged 12 years and older are prescribed 5 mg 1 time / day, regardless of meals, preferably at the same time of day.

    The tablet should be swallowed whole, without chewing, with a small amount of water.

    Children aged 1 to 5 years are prescribed 1.25 mg (2.5 ml of syrup) 1 time / day; children aged 6 to 11 years - 2.5 mg (5 ml syrup) 1 time / day; adults and adolescents over 12 years old - 5 mg (10 ml syrup) 1 time / day.

    The syrup is taken orally, regardless of food intake, with a small amount of water.

    Film-coated tablets

    General reactions: increased fatigue (1.2%), headache (0.6%).

    From the cardiovascular system: very rarely - tachycardia, palpitations.

    From the digestive system: dry mouth (0.8%); very rarely - increased activity of liver enzymes, increased bilirubin concentration.

    Allergic reactions: very rarely - anaphylaxis, rash.

    In children under 2 years of age, the following adverse events were observed when using Erius, the frequency of which was slightly higher than when using placebo (≥1/100 to <1/10): diarrhea (3.7%), increased body temperature (2.3% ), insomnia (2.3%).

    In children aged 2 to 11 years, the incidence of side effects with Erius was the same as with placebo.

    In adults and adolescents aged 12 years and older, when using the drug Erius, the frequency of side effects was slightly higher compared to placebo (≥1/100 to <1/10), of which fatigue, dry mouth, and headache were most often noted. .

    When using Erius in adults and adolescents at the recommended dose of 5 mg/day, the incidence of drowsiness was no higher than when using placebo.

    The following side effects have been reported very rarely (<1/10,000).

    From the side of the central nervous system: dizziness, drowsiness.

    From the cardiovascular system: tachycardia, palpitations.

    From the digestive system: abdominal pain, nausea, vomiting, dyspepsia, diarrhea, increased levels of bilirubin, liver enzymes in the blood serum.

    Allergic reactions: anaphylaxis, angioedema, itching, rash, urticaria.

    Symptoms: Taking a dose 5 times the recommended dose did not result in any symptoms.

    In clinical studies, daily use of desloratadine up to 20 mg for 14 days in adults and adolescents was not associated with statistically or clinically significant changes in the cardiovascular system. In a clinical pharmacological study, the use of desloratadine at a dose of 45 mg/day (9 times higher than recommended) for 10 days did not cause prolongation of the QT interval and was not accompanied by serious side effects.

    Treatment: in case of accidental ingestion of a large amount of the drug - gastric lavage, intake of activated charcoal; if necessary, symptomatic therapy. Desloratadine is not eliminated by hemodialysis; the effectiveness of peritoneal dialysis has not been established.

    Studies have not revealed interactions with azithromycin, ketoconazole, erythromycin, fluoxetine and cimetidine.

    Erius does not enhance the effects of ethanol on the central nervous system.

    Eating does not affect the effectiveness of the drug.

    There have been no studies of the effectiveness of the drug Erius for rhinitis of infectious etiology.

    Use in pediatrics

    The effectiveness and safety of Erius in syrup form in children under 1 year of age has not been established.

    Impact on the ability to drive a car and operate machinery

    At the recommended dose, Erius does not affect the ability to drive vehicles or operate machinery.

    The use of the drug during pregnancy is not recommended due to the lack of clinical data on the safety of its use during this period.

    Desloratadine is excreted in breast milk, so the use of Erius during breastfeeding is not recommended.

    The effectiveness and safety of using Erius in syrup form in children under 1 year of age has not been established.

    Contraindicated under the age of 1 year (for syrup), under the age of 12 years (for film-coated tablets).

    In most cases, rhinitis in children under 2 years of age is infectious in nature. There have been no studies of the effectiveness of Erius for rhinitis of infectious etiology.

    Differential diagnosis between allergic rhinitis and rhinitis of other origin in children under 2 years of age presents certain difficulties. The differential diagnosis should include consideration of the presence or absence of foci of infection or structural abnormalities of the upper respiratory tract, a thorough history, examination, and appropriate laboratory tests and skin tests. .

    To ask a question about the project or contact the editors, use this form.

    Source: http://health.mail.ru/drug/erius/

    Erius - the original third generation antihistamine

    Erius is an original remedy that is one of the safest medicines used to treat hay fever and urticaria. After using the drug, there is no drowsiness, and side effects develop extremely rarely. This article is devoted to a review of the instructions for use and prices of Erius for children and adults, its reviews and analogues.

    Features of the drug

    The drug Erius (Belgium, Schering-Plough) is a third-generation antihistamine, characterized by a long-lasting effect.

    This video will introduce you to Erius tablets:

    Composition of Erius

    The properties of the patented product are determined by its active component desloratadine. One tablet of Erius, coated with a thin film, contains 5 mg of this compound, 1 ml of syrup - 0.5 mg of desloratadine.

    Dosage forms

    Erius is available as:

    • Tablets bearing a special SP mark (Schering-Plough brand name), coated with a thin blue film - the price for 10 pieces is 570 rubles, the cost of a blister containing 7 tablets does not exceed 300 rubles;
    • Syrup - orange liquid in a dark glass bottle, costing 570 rubles for 60 ml, 750 rubles for 120 ml.

    The tablets are packaged in 10 pieces, each containing 5 mg of desloratadine. The syrup is packaged in dark glass bottles with a volume of 60 ml, 120 ml, and packed in boxes, where they are placed along with the instructions.

    pharmachologic effect

    Erius belongs to the group of antihistamines and has the properties of an H1-histamine receptor blocker.

    Pharmacodynamics

    Desloratadine is a metabolite of loratadine. The compound blocks the release of interleukins, which provoke inflammation, and prevents the release of histamine caused by the action of IgE.

    Erius eliminates muscle spasms, reduces the permeability of the network of blood capillaries, and prevents the appearance of edema. The drug has a long-lasting antihistamine effect, the effect appears 30 minutes after use and lasts for at least a day.

    Pharmacokinetics

    • Absorption of desloratadine occurs in the stomach. Desloratadine does not have properties that could facilitate its penetration through the blood-brain barrier.
    • With long-term treatment with this drug, the medicine does not accumulate in the body, even if used in large dosages. The maximum concentration of desloratadine is achieved 3 hours after taking the tablet.
    • The drug is metabolized in the liver and excreted by the kidneys. The effect of the drug in the body does not depend on food intake, and the activity of the drug does not decrease when drinking grapefruit juice.

    Indications

    Erius quickly eliminates allergy symptoms such as sneezing, itching, runny nose, and relieves watery eyes in case of exacerbation:

    Sometimes Erius and other antihistamines are used when vaccination against papilloma virus.

    Instructions for use

    All dosage forms of Erius are taken once a day.

    Pills

    Erius is drunk once a day, taking 5 mg once. The tablet should be taken with plenty of water, preferably taken between meals.

    Syrup

    When taking the syrup, wash it down with a small amount of water and consume it once:

    • children after 1 year to 5 years – 2.5 ml;
    • from 6 to 11 years – use 5 ml;
    • after 12 years, drink 10 ml of the product.

    Erius syrup exhibits antiallergic activity in atopic dermatitis in children, eliminates itching, and reduces the number of rashes.

    Contraindications

    Tablets can be used by children from 12 years of age, syrup can be given to a child after reaching 1 year. Erius is contraindicated in the following cases:

    • individual hypersensitivity;
    • pregnancy, lactation.

    Severe renal failure may be a contraindication to the use of the drug.

    Side effects

    Only in rare cases, when treated with Erius, side effects occur that are caused directly by the use of this drug.

    Pills

    When taking tablets, sometimes there is an increase in heart rate, tachycardia, dry mouth, weakness, and a headache may occur. In exceptional cases, taking the drug can provoke an allergy, which manifests itself as skin rashes and anaphylaxis.

    Syrup

    • Taking syrup in a child under 2 years of age is sometimes accompanied by a rise in temperature, insomnia, and upset bowel movements. After consuming the syrup, nausea, dizziness, increased heart rate, and drowsiness may occur.
    • In extremely rare cases, adolescents and adults develop angioedema and anaphylactic shock when taking syrup.

    special instructions

    • In case of overdose, the patient's stomach is washed and offered to drink activated charcoal.
    • Erius does not have a sedative effect and does not affect the ability to drive.

    Interaction

    The use of Erius in tablets or syrup form does not affect the effectiveness of other drugs that are used in complex therapy. Reviews of syrup and other forms of Erius are given below.

    Reviews

    • Most buyers recommend using Erius medicine for allergies in adults and children. It is noted that the product quickly helps against various types of allergies and begins to act almost instantly. Among the disadvantages of the medicine is the rather high cost.
    • As practice shows, taking the drug is not addictive. This allows it to be used in the treatment of long-term courses of seasonal runny nose and pollen allergies. Erius is effective for bronchial asthma, atopic dermatitis, and is well tolerated.

    You will learn about cheaper and, on the contrary, more expensive analogues of Erius below.

    Analogs

    Treatment with Erius can be replaced by taking its analogues - Lordestin, Trexil, Telfast, Allergostop, Eridez, Loratadine.

    The video below will tell you about Erius and La Cree as a remedy for allergies:

    Source: http://gidmed.com/dermatologiya/lekarstva-derm/erius.html

    Erius lozenges: instructions for use, the nature of the drug’s effect on the course of the allergic process

    Signs of allergic rhinitis, bronchitis and conjunctivitis, dermatoses, hay fever, and urticaria cause patients considerable discomfort. It is important to choose a modern antihistamine so that the quality of life does not decrease. Many doctors recommend the drug Erius. Lozenges actively block histamine receptors and quickly relieve negative symptoms.

    The drug acts throughout the day and rarely provokes a negative response from the body. Instructions for use of the drug Erius contain a description of the tablets, indications, the nature of the effect on the course of the allergic process, recommendations for taking the drug for patients of different ages.

    Composition and release form

    Desloratadine is the active ingredient of the antiallergic drug Erius. The active component of the drug blocks peripheral histamine H1 receptors, drowsiness, and rarely provokes negative effects. Desloratadine does not penetrate the blood-brain barrier, and the list of side effects is minimal.

    The antiallergic drug Erius for adults and children over 12 years of age goes on sale in the form of lozenges. Each unit contains 5 mg of desloratadine and additional ingredients. The tablets are enclosed in a film shell, 7 or 10 pieces in a blister.

    Action

    The antiallergic drug Erius has a positive effect on the body with various manifestations of allergies. The product is suitable for eliminating sneezing, coughing, runny nose, itchy skin, hyperemia, swelling of tissues in chronic and acute forms of allergic diseases.

    Effect of desloratadine:

    • suppression of processes that provoke allergic inflammation;
    • decreased permeability of the capillary wall;
    • antipruritic effect;
    • antiexudative and antiallergic effect;
    • weaker symptoms of allergic diseases or complete disappearance of negative signs.

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    • rapid relief of negative reactions;
    • long period of action in the body – a day or more;
    • drowsiness occurs in rare cases;
    • the speed of psychomotor reactions remains at the usual level;
    • the result of the action of desloratadine is noticeable already half an hour after the tablets are dissolved;
    • an antiallergic drug successfully replaces injections of antihistamines in acute forms of urticaria, if it is impossible to give an anti-allergy injection;
    • an antihistamine is combined with most types of medications;
    • the possibility of use for several weeks or more in case of seasonal nature of negative reactions, for example, hay fever, allergic cough and runny nose;
    • a long-acting antihistamine allows you to drive a car, not lose your activity, and maintain coordination at a sufficient level. The absence of an inhibitory effect on the nervous system of patients is one of the advantages of the modern antiallergic composition of the new generation;
    • Erius in tablet form is approved for patients over 12 years of age.

    Indications for use

    An effective antihistamine is allowed to be used in the following cases:

    • idiopathic urticaria of chronic type. Skin itching decreases or disappears, the epidermis is cleared of allergic rashes;
    • hay fever, allergic rhinitis (year-round variety). Significant improvement in condition, relief or disappearance of symptoms. The patient is less likely to be bothered by sneezing, the volume of mucus discharge from the nose decreases, redness, itching of the eyelids and conjunctiva, palate, and nasal congestion disappear or decrease.

    Contraindications

    A drug with an active antiallergic effect has several restrictions for taking tablets:

    • pregnancy;
    • high sensitivity to the active substance or other components;
    • breastfeeding period;
    • phenylketonuria;
    • for tablets – age up to 12 years.

    Instructions for use and dosage

    The antihistamine composition is prescribed by a doctor; purchasing and taking tablets with desloratadine on the patient’s initiative is not recommended. An allergy sufferer must carefully study the package insert with a description of the drug, instructions for use, daily dosage, and clarify possible side effects and contraindications.

    • eating does not affect the effect of the medicine;
    • carefully open the blister, take out the tablet, and immediately put it in your mouth;
    • the product dissolves quickly, a portion of water is not needed (if desired, you can wash down the tablet with a tablespoon of liquid);
    • a drug with a prolonged action is enough to take 1 time during the day: 1 tablet or 5 mg of desloratadine;
    • For patients suffering from seasonal symptoms of allergic rhinitis, take the medicine until the symptoms disappear;
    • if signs of an allergic rhinitis appear more often than 4 times a week or longer than one month, take an antihistamine for the entire period while the irritant is active;
    • The shelf life of the antiallergic drug is 24 months, the optimal storage temperature is up to + 30 degrees. Do not open the blister in advance: the tablets must be taken immediately after opening the sealed package.

    In the optimal dosage, desloratadine does not impair the speed of psychomotor reactions and does not affect the ability to adequately control complex mechanisms and vehicles.

    Possible side effects

    Negative signs after taking Erius tablets were recorded in rare cases - from 0.6 to 1.2% of patients complained of discomfort and reactions of various kinds. If the frequency, single and daily dosage is strictly observed, we can talk about the safety of the antiallergic drug.

    Possible side effects:

    • headache;
    • weakness, increased fatigue;
    • dry mouth.

    How does an allergy to sweets manifest itself in children and how to treat the pathology? We have the answer!

    For a list of new generation antiallergic drugs for children, see this page.

    Go to http://allergiinet.com/lechenie/preparaty/mazi-dlya-kozhi.html and see a review and characteristics of ointments for itching due to allergies.

    The following reactions were even less common:

    • high activity of liver enzymes;
    • tachycardia;
    • anaphylactic reactions;
    • allergic skin rash.

    If negative signs appear, stop taking allergy pills and consult a doctor. Taking sorbents and drinking plenty of fluids helps speed up the elimination of the active substance. The doctor will tell you how to replace an effective antiallergic drug.

    Drug interactions

    During the studies, no negative results or negative effects on the body were revealed when combining Erius tablets and other drugs. Patients should remember: taking antihistamines and alcohol is undesirable.

    The new generation antihistamine has a lot of advantages, few disadvantages, among them is high cost. The effective drug Erius was produced by the famous pharmaceutical company Schering Plow (USA). Even with the high quality of the medicine, the price of Erius tablets is not encouraging: package No. 7 costs 400 rubles, package No. 10 costs 640 rubles.

    Analogs

    Among the new generation of drugs to eliminate allergy symptoms, there are many effective drugs that can replace Erius tablets. Only a doctor should select an analogue with desloratadine or another active substance. This point is especially important when prescribing the drug to children: many allergy pills are allowed only from 12 years of age, some drugs have more side effects.

    Long-acting antihistamines, analogues of Erius tablets:

    Reviews

    Most doctors recommend to patients a high-quality American drug with a prolonged action. The high price is a noticeable drawback, but the safety of the product and the minimum of side effects explain the high level of sales of the antihistamine.

    Active influence on the initial and late stages of allergic reactions quickly eliminates the signs of allergy, fights allergic bronchitis, and maintains the quality of life at an acceptable level in chronic types of urticaria, allergic conjunctivitis, and rhinitis. Children aged 12 years and older tolerate taking the pills well; fatigue and dry mouth rarely appear. Sometimes patients complain of weakness, headaches, but there is no drowsiness or inhibition of reactions.

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    Source: http://allergiinet.com/lechenie/preparaty/tabletki-erius.html