Beclomethasone reviews from patients

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Beclomethasone

Beclomethasone: instructions for use and reviews

Latin name: Beclomethasone

ATX code: R01AD01

Active ingredient: beclometasone

Manufacturer: JSC Moskhimfarmpreparaty named after.

Table of contents:

N. A. Semashko, CJSC Binnopharm (Russia), Orion Corporation Orion Pharma (Finland)

Update of description and photo: 11/29/2017

Prices in pharmacies: from 131 rub.

Beclomethasone is a hormonal drug (glucocorticosteroid) intended for inhalation use to affect the mucous membrane of the respiratory organs; one of the basic course of treatment for bronchial asthma.

Release form and composition

The active ingredient is beclomethasone dipropionate.

Available in the form of a dosed aerosol for inhalation (200 doses in aluminum aerosol cans with a spray system, 1 can in a cardboard box).

The content of the active substance in 1 dose is 50 mcg or 250 mcg.

Pharmacological properties

Pharmacodynamics

Beclomethasone is a glucocorticosteroid and has a weak affinity for GCS receptors. With the participation of enzymes, it is converted into an active metabolite - beclomethasone-17-monopropionate (B-17-MP), which is characterized by a clearly expressed local anti-inflammatory effect. Beclomethasone reduces the intensity of the inflammatory process by suppressing the formation of a chemotaxis substance (impact on late allergic reactions), slows down the development of immediate allergic reactions, which are caused by inhibition of the synthesis of arachidonic acid metabolites and a decrease in the release of inflammatory mediators from mast cells, and also stimulates mucociliary transport processes.

The drug reduces the number of mast cells in the bronchial mucosa, suppresses mucus secretion by the bronchial glands, reduces swelling of the epithelium, bronchial hyperreactivity, marginal accumulation of neutrophils, and also suppresses the production of lymphokines and inflammatory exudate, slows down the migration of macrophages and helps reduce the intensity of granulation and infiltration processes.

Thanks to beclomethasone, the number of active beta-adrenergic receptors increases, the patient’s response to bronchodilators is restored, which makes it possible to reduce the frequency of their use. After inhalation administration, the substance has virtually no resorptive effect.

The drug does not have the ability to relieve bronchospasm, and the therapeutic effect develops gradually with maximum severity usually 5–7 days after the start of therapy.

Pharmacokinetics

More than 25% of beclomethasone administered by inhalation settles in the respiratory tract, and the remaining amount settles in the pharynx and oral cavity and is swallowed. In the lungs, before absorption begins, the compound is actively metabolized, forming the active metabolite B-17-MP. Systemic absorption of the latter occurs in the lungs (up to 36% of the pulmonary fraction of the substance) and the gastrointestinal tract (up to 26% of the amount received here upon ingestion). The absolute bioavailability of beclomethasone in unchanged form and B-17-MP is approximately 2% and 62%, respectively, of the dose administered to the body in the form of inhalation.

Beclomethasone is absorbed at a high rate, and the maximum concentration of the substance in the blood plasma is reached in 0.3 hours. B-17-MP is absorbed more slowly. The time to reach the maximum concentration of this metabolite is about 1 hour. An approximate linear relationship was found between increasing the dose administered by inhalation and systemic exposure to the active component of the drug.

For beclomethasone, tissue distribution is 20 l, and for B-17-MP – 424 l. The drug binds quite well (87%) to plasma proteins.

Beclomethasone and B-17-MP are characterized by high plasma clearance of 150 l/h and 120 l/h, respectively. The half-life is 0.5 hours and 2.7 hours, respectively.

Indications for use

The action of the drug is aimed at reducing epithelial edema, mucus secretion by bronchial glands, marginal accumulation of neutrophils, bronchial hyperreactivity, inflammatory exudate (fluid at the site of inflammation).

According to the instructions, Beclomethasone is prescribed in the following cases:

  • Bronchial asthma (inhalation use);
  • Prevention and treatment of allergic rhinitis, including vasomotor and rhinitis due to hay fever (intranasal use);
  • Infectious and inflammatory diseases of the ear and skin (external and local) - in combination with antimicrobial agents.

Contraindications

  • Bronchitis of non-asthmatic nature, acute bronchospasm;
  • Frequent nosebleeds, hemorrhagic diathesis;
  • Systemic infections, including pulmonary tuberculosis, acute respiratory infections, herpetic eye lesions.

Beclomethasone aerosol is contraindicated in children under 6 years of age and women in the first trimester of pregnancy.

Instructions for use of Beclomethasone: method and dosage

  • Adults - 500 mcg 2 times a day or 250 mcg 4 times a day, the daily dose should not exceed 1000 mcg (2000 mcg is allowed only in very severe cases, and the daily dose is divided into 4 doses);
  • Children from 6 years old - pump 2 to 4 times a day.
  • Adults and children over 12 years of age - 100 mcg 3-4 times a day in each nasal passage, not exceeding a daily dose of 1000 mcg;
  • Children 6-12 years old - 50 mcg in each nasal passage (no more than 500 mcg per day) with the same frequency of doses as adults.

A more precise dosage regimen and duration of treatment is determined by the doctor.

Side effects

Beclomethasone aerosol may cause undesirable reactions of the body, in particular, such as:

  • Sneezing, cough, throat irritation, dysphonia, rarely – paradoxical bronchospasm (relieved by inhaled bronchodilators), eosinophilic pneumonia;
  • Candidomycosis of the upper respiratory tract and oral cavity;
  • Dizziness, headaches, increased intraocular pressure, cataracts, lymphopenia, eosinopenia, leukocytosis - with long-term use in large doses;
  • Nosebleeds, rhinitis, perforation of the nasal septum, atrophy of the mucous membrane - with intranasal use;
  • Dysfunction of the hypothalamic-pituitary-adrenal system - with a single use of more than 1000 mcg of beclomethasone dipropionate;
  • Allergic reactions.

Overdose

It is possible to develop symptoms of acute overdose with a single inhalation of a high dose of more than 1 g. In this case, signs of suppression of the function of the adrenal cortex most often appear, and there is no need for emergency therapy. This is explained by the restoration of this function over several days, which is confirmed by changes in the level of cortisol in the blood plasma.

In case of chronic overdose (long-term treatment with the drug in doses of more than 1.5 g), persistent suppression of the function of the adrenal cortex can be observed. In such a situation, the reserve function of the adrenal cortex should be regularly monitored. In case of overdose, the course of treatment with Beclomethasone can be continued provided doses sufficient to maintain the therapeutic effect are administered.

special instructions

For women in the second and third trimesters of pregnancy, as well as nursing mothers, the advisability of using Beclomethasone is determined by a doctor. If the drug is taken during lactation, breastfeeding should be discontinued.

Caution is required when using the spray intranasally by persons with ulcerations of the nasal septum, glaucoma, amebiasis, hypothyroidism, and severe renal failure.

A recent myocardial infarction, nasal surgery and nasal trauma performed in the recent past are reasons to limit the use of Beclomethasone.

Impact on the ability to drive vehicles and complex mechanisms

Inhaled Beclomethasone does not significantly affect the ability to drive vehicles or engage in potentially hazardous activities that require increased reaction speed and serious concentration.

Use during pregnancy and lactation

The drug is used with extreme caution during pregnancy and breastfeeding, only if the expected benefit to the mother exceeds the possible risks to the fetus and baby.

Newborns whose mothers were treated with Beclomethasone during pregnancy should be carefully examined for adrenal insufficiency.

Use in childhood

Children under 6 years of age are not prescribed.

The drug, which contains 250 mcg of beclomethasone in 1 dose, is not intended for children under 18 years of age. When administered by inhalation, a single dose for children is 50–100 mcg, and the frequency of use does not exceed 2–4 times a day.

Drug interactions

Beclomethasone restores the patient's response to beta-agonists, which significantly reduces the frequency of their use.

When the drug is combined with rifampicin, phenytoin, phenobarbital and other inducers of microsomal liver enzymes, the therapeutic effect of beclomethasone becomes weaker.

The simultaneous use of beclomethasone with theophylline, methandienone, beta 2 -adrenergic agonists , estrogens, and systemic glucocorticosteroids helps to increase the effectiveness of beclomethasone.

When Beclomethasone and beta-agonists are taken together, the effect of the latter on the body is enhanced.

In particularly sensitive patients, beclomethasone may interact with metronidazole and disulfiram due to the ethyl alcohol content in the drug.

Analogs

Direct analogues of Beclomethasone, having beclomethasone dipropionate as the active ingredient: Beclomethasone Eco, Beclat, Beclospir, Bekotide, Klenil, Beclomethasone Eco Easy Breathing, Beclomethasone-aeronativ.

Drugs of similar action belonging to the same pharmaceutical subgroup: Asmanex Twistheiler, Benacort, Budecort, Budenit Steri-Neb, Budesonide, Budesonide Easyhaler, Budiair, Pulmicort, Tafen Novolizer, Flixotide, Alvesco, Novopulmon E Novolizer, Budesonide-native.

Terms and conditions of storage

Store at a temperature not exceeding 30 °C.

Shelf life - 3 years; after opening the spray, the contents should be used within 6 months.

Conditions for dispensing from pharmacies

Dispensed by prescription.

Reviews about Beclomethasone

According to reviews, Beclomethasone in most cases helps to quickly alleviate the patient’s condition. There are reports of unpleasant side effects, but in general, doctors and patients consider it an effective drug.

Price for Beclomethasone in pharmacies

The average price for Beclomethasone, which contains 50 mcg in 1 dose, is 131–188 rubles. The cost of an inhalation aerosol, which contains 250 mcg in 1 dose, varies from 385 to 410 rubles.

Beclomethasone Orion Pharma 50 µg/dose 23 ml (200 doses) nasal spray

Beclomethasone 100mcg/dose 200 doses aerosol for inhalation

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Source: http://www.neboleem.net/beclometazon.php

The drug "Beclomethasone": instructions for use, indications, analogues, reviews

Aerosol "Beclomethasone" is a hormonal glucocorticosteroid drug, which is intended for inhalation use to affect the mucous membrane of the respiratory canals. This medicine serves as one of the basic course of treatment for bronchial asthma.

Instructions for Beclomethasone are presented below.

Composition and release form of the medicinal product

The active component of this medication is beclomethasone dipropionate. The drug is released in the form of a metered spray. The medicine is produced in different volumes of nine, ten and twenty-three milliliters. The drug substance is contained in polyethylene bottles with a dispenser; in addition, the kit includes a spray nozzle. The nozzle and bottle are enclosed in a cardboard package.

Pharmacological action of the drug

According to the instructions, Beclomethasone has anti-inflammatory, anti-allergic, decongestant, anti-asthmatic and anti-exudative effects. Pharmacists note the pronounced glucocorticoid activity of the drug, as well as its weak mineralocorticoid effect.

What is the main effect of Beclomethasone?

The drug is able to increase the production of lipomodulin and reduce the release of arachidonic acid, reducing the synthesis of prostaglandins. Due to the reduction in the production of inflammatory exudate, along with lymphokines, the migration of macrophages is inhibited, which is accompanied by a slowdown in the processes of infiltration and granulation, among other things. Due to the influence of the presented drug, the basement membranes of the epithelium become thicker. In addition, the process of mucus secretion slows down due to goblet cells, and the number of fatty elements in the bronchial mucosa decreases. Also, the active component of the drug is able to relax the smooth muscles of the bronchi, promoting the active and rapid restoration of its sensitivity. This is confirmed by the instructions for use.

Beclomethasone restores the body's response to bronchodilators and, as a result, reduces the frequency of their use. This medication helps improve the functionality of external respiration. When the drug is used in therapeutic doses, adverse reactions characteristic of systemic hematopoietic stem cells are not observed. When using the product intranasally, hyperemia and swelling of the nasal mucosa are eliminated.

Beclomethasone analogues are of interest to many.

Pharmacokinetics and pharmacodynamics of the drug

When used intranasally, the active substance is absorbed through the nasal mucosa; in addition, a low level of absorption from the digestive system is noted.

Absorption, as a rule, occurs regardless of the type of administration. The substance is usually eighty-seven percent bound to plasma proteins. The main part is excreted from the body through the intestines, and about fifteen percent exits through the kidneys.

The therapeutic effect is observed within four to five days after the start of treatment, its peak can be observed within several weeks.

After administration of Beclomethasone aerosol by inhalation, some of the dose may be absorbed in the lungs. The bulk of the substance entering the digestive organs is inactivated during its first passage through the liver.

Indications for use of the medication

As the instructions for Beclomethasone indicate, the use of the presented drug by inhalation is prescribed for bronchial asthma as a basic treatment. In addition, the drug is used in situations of insufficient effectiveness of ketotifen, cromoglycic acid and bronchodilators in order to be able to reduce the dosage.

Intranasal use is advisable against the background of allergic rhinitis, both seasonal and permanent manifestations. Among other things, the prescription of Beclomethasone (in Latin - Beclometasonum) is practiced as part of the treatment of recurrent nasal polyposis and vasomotor rhinitis.

Local and external use of the product is practiced in combination with antimicrobial drugs against the background of infectious and inflammatory diseases of the ears and skin.

What else does the instructions for use for Beclomethasone say?

Contraindications to the use of the drug

The drug should not be used in cases of high sensitivity and under the age of six years. Inhalation use, in turn, is not practiced in the following situations:

  • Presence of acute bronchospasms.
  • As part of status asthmaticus, the drug is not used as a first-line medication.
  • Bronchitis of non-asthmatic origin.

Intranasal use should not be carried out with the following contraindications:

The indications for Beclomethasone must be strictly followed. It is also important to take into account that there are restrictions for intranasal use. These, as a rule, are recent surgical interventions in the nasal cavity along with ulcerations of the septum, recent injuries, glaucoma, amebiasis, hypothyroidism and severe liver failure. It is also recommended to use this drug with extreme caution if you have recently experienced a myocardial infarction. This points to the "Beclomethasone" instructions.

Side effects of the drug

When performing inhalations, the following adverse reactions are possible:

  • The appearance of a sore throat and hoarseness.
  • The occurrence of cough along with sneezing.
  • The presence of eosinophilic pneumonia and paradoxical bronchospasms.
  • Allergic reactions.

Treatment of candidiasis of the oral cavity, as well as the upper respiratory canals, occurs with the use of antifungal therapy, so taking Beclomethasone should not be stopped. It is important to keep in mind that systemic adverse reactions may occur when using the drug in excess doses of more than one and a half milligrams per day. The trade name "Beclomethasone" interests many. There are quite a large number of them - these are “Nasobek”, “Beclazon”, “Aldecin”, “Beconase”, “Beclamethasone DS” and so on.

When administered intranasally, the following side effects are likely:

  • The appearance of irritation and dryness of the nasal mucosa.
  • Pain in the throat and nasal cavity.
  • Nosebleeds.
  • The presence of nasopharyngeal infections that are caused by fungal flora.
  • The process of perforation of the nasal septum.
  • Rhinorrhea along with ulceration of the nasal mucosa.

If the drug is used for a long time in large doses, exceeding one and a half thousand micrograms per day, systemic adverse reactions may occur.

Systemic effects are likely to include dizziness and eye pain, along with drowsiness, increased intraocular pressure, visual disturbances, conjunctival hyperemia, changes in taste, allergic manifestations and myalgia. Long-term use of Beclomethasone may cause growth retardation in children.

Instructions for use of the drug

Instructions for use of the drug "Beclomethasone" provide for intranasal as well as inhalation use. In order to achieve pronounced results, it is recommended to use this product regularly. Dosing for inhalation use directly depends on the characteristics of the disease. Children should take a lower dose compared to adults.

When using a form of the drug containing fifty or one hundred micrograms of beclomethasone per dose, adults should receive this amount three to four times a day. If necessary, the dosage can be increased to six hundred to eight hundred micrograms. Children should receive fifty micrograms twice a day.

If a form of the drug is used containing two hundred and fifty micrograms of the active ingredient in one dose, then adult patients need to receive double the amount of this norm twice a day. If required, the dosage is increased to one and a half to two thousand micrograms per day. As part of intranasal use, fifty micrograms of Beclomethasone are injected into each nasal passage for inhalation two to four times a day.

Overdose

In case of overdose, as a rule, symptoms associated with pituitary-hypothalamic-adrenal insufficiency occur. In such a situation, the patient is transferred to treatment with systemic glucocorticoids for some time, and adrenocorticotropic hormones are also prescribed.

Interaction of the drug with other medications

With simultaneous use, the effect of beta-agonists is enhanced. Beta-adrenergic agonists, in turn, increase the anti-inflammatory effect of Beclomethasone, increasing the degree of penetration of its substance into the distal regions of the bronchi. Ephedrine can activate metabolic processes.

The effectiveness of Beclomethasone can be significantly reduced by inducers of elements of the microsomal oxidation process. When taken together with estrogens, methandienones, theophylline, beta2-adrenergic agonists and oral glucocorticoids, the effect of the active component of the drug is activated.

Terms of sale and storage

This medicine can be purchased only with a prescription. It should be stored in a dark place while maintaining a temperature of up to thirty degrees. The shelf life of Beclomethasone is three years, and after opening the drug can be stored for no more than six months.

Special instructions for use of the drug

This medicine should not be used to relieve acute asthmatic attacks. If acute attacks of bronchial asthma occur in response to the use of Beclomethasone, such treatment must be immediately discontinued.

In situations where patients have symptoms of pituitary-hypothalamic-adrenal insufficiency, patients can continue inhalations, but they will require strict monitoring of the presence of basal cortisol in plasma. In the same way, it is necessary to monitor these indicators if significant doses of beclomethasone are used for therapy.

Against the background of broncho-obstructive syndrome in moderate or severe form, it is necessary to use bronchodilators approximately twenty minutes before inhalation. Under no circumstances should the drug come into contact with the eyes.

When treating allergic rhinitis with severe symptoms, the effectiveness of the drug increases if it is used simultaneously with vasoconstrictors. In order to reduce the risk of pharyngeal candidiasis, inhalations should be carried out before meals, and also rinse your mouth after each procedure.

People with steroid-dependent asthma need to take higher doses of this medication. Patients with asthma should gradually switch from systemic glucocorticoids to inhaled Beclomethasone. Do not sharply reduce the dose.

Use of Beclomethasone during pregnancy

It is prohibited to use this drug to treat pregnant women in the first trimester, and in the second and third trimester it is allowed to use this medicine only when the expected benefit outweighs the probable level of risk. Children born to mothers who received Beclomethasone during pregnancy must be examined for the presence of functional adrenal insufficiency. As for breastfeeding during Beclomethasone therapy, it should definitely be stopped.

Analogues of "Beclomethasone"

Direct analogues that have beclomethasone dipropionate as an active ingredient are: “Beclat”, “Bekotide”, “Klenil” and “Beclomethasone-aeronativ”.

Medicines that have a similar effect and are related to the same pharmaceutical subgroup are the following medications: Benacort, Budenit, Budesonide, Budiair, Pulmicort, Flixotide, Novolizer and others.

Reviews about "Beclomethasone"

Reviews about this drug indicate that most often it helps to alleviate the condition of patients. There is information about the occurrence of some adverse reactions, but in general the comments from people who have been treated with the drug are positive.

Many people call it their salvation. Patients write that one dose of this remedy lasts them twelve hours. Thus, it is noted that the medicine perfectly helps to get rid of a painful cough and sore throat with frequent contact with allergens. In the comments, patients say that this medication always helps them effectively, and also that they often take it with them just in case.

In addition, it is reported that as part of annual treatment with Beclomethasone, this drug significantly improves the well-being of people suffering from bronchial asthma, as a result of which shortness of breath and cough disappear. Buyers cite the main disadvantage of this medicine as the price, which is four hundred rubles per bottle.

Source: http://www.syl.ru/article/355219/preparat-beklometazon-instruktsiya-po-primeneniyu-pokazaniya-analogi-otzyivyi

Beclomethasone

Release forms

Storage: 15-25C (room temperature)

Shelf life: 36 months.

Storage: 15-25C (room temperature)

Shelf life: 36 months.

Beclomethasone instructions

Beclomethasone is a glucocorticosteroid drug. It is administered by inhalation (for bronchial asthma) or intranasally (for allergic rhinitis). Shows anti-inflammatory and anti-allergic effect. Prevents the release of biologically active substances that cause biochemical and structural transformations of tissues and metabolic processes occurring in them, as a result of which an inflammatory reaction develops. Stimulates the production of lipocortin (antiphospholipase). Inhibits the release of arachidonic acid, which, in turn, is a substrate for the synthesis of prostaglandins, causing local inflammatory reactions. Warns the so-called marginal standing (accumulation near the walls of blood vessels) of neutrophilic granulocytes, suppressing the process of formation of inflammatory exudate - liquid that accumulates in the extravascular space during inflammation as a result of increased capillary permeability. Inhibits the production of lymphokines, regulators of cellular immunity. Inhibits the migration of mononuclear phagocytes, which slows down infiltration (penetration and accumulation in tissues of substances or particles that are not their normal constituents) and granulation (transition of the inflammatory phase to the proliferation phase, controlled by inflammatory cells). Increases the number of active beta-adrenergic receptors, neutralizes their desensitization, increases the patient's sensitivity to bronchodilators, which allows reducing the frequency of their use and reducing the overall pharmacological load on the body and the risk of side effects.

Reduces the number of mastocytes in the mucous membrane of the lower respiratory tract, eliminates swelling of epithelial tissue, suppresses the secretory activity of the bronchial glands. Reduces the tone of the smooth muscles of the bronchi, making them less sensitive to the effects of provoking factors. It does not have mineralocorticoid activity (the ability to retain sodium in the body and promote the elimination of potassium and calcium). When used in the doses indicated in the instructions for use, it does not cause side effects characteristic of systemic glucocorticosteroids. When introduced into the nasal passages, it relieves swelling of the mucous membrane and reduces its blood supply. The therapeutic effect of the drug usually develops after 5-7 days of regular use. In pediatric practice it is used starting from the age of 12. Not intended for the relief of acute and/or severe attacks of bronchial asthma requiring urgent therapeutic intervention. In patients with adrenal insufficiency, the drug is used with extreme caution. Transfer of patients constantly taking tableted glucocorticosteroids to the inhalation route of administration can be carried out only when the clinical picture has stabilized. If thrush develops in the oral cavity and upper respiratory tract, local antimycotic therapy is indicated without discontinuing beclamethasone.

Patient reviews of beclomethasone

My son is 15 years old. He has been suffering from bronchial asthma since he was 4 years old, and all this time we have been fighting this disease. The exacerbation of the disease is seasonal, from spring to late autumn. During this time, we tried many drugs, many stopped having an effect, the allergist identified a hormone-dependent form of bronchial asthma and individually selected various hormonal drugs for his son, but the attacks of suffocation continued steadily once a day. Beclomethasone was prescribed. After a week, my son felt a little better, and after 3 weeks he was completely happier. Attacks of suffocation have been reduced by half. We will continue to be treated with beclomethasone.

Instructions for use of beclomethasone

pharmachologic effect

GCS. Has anti-inflammatory and anti-allergic effects.

Inhibits the release of inflammatory mediators, increases the production of lipomodulin - an inhibitor of phospholipase A, reduces the release of arachidonic acid, and inhibits the synthesis of prostaglandins. Prevents the marginal accumulation of neutrophils, reducing the formation of inflammatory exudate and the production of lymphokines, inhibits the migration of macrophages, which leads to a slowdown in the processes of infiltration and granulation.

Increases the number of active β-adrenergic receptors, neutralizes their desensitization, restores the patient's response to bronchodilators, allowing them to be used less frequently.

Under the influence of beclomethasone, the number of mast cells in the bronchial mucosa decreases, the swelling of the epithelium and the secretion of mucus by the bronchial glands decreases. Causes relaxation of bronchial smooth muscles, reduces their hyperreactivity and improves external respiration function.

Does not have mineralocorticoid activity.

In therapeutic doses it does not cause side effects characteristic of systemic corticosteroids.

When used intranasally, it eliminates swelling and hyperemia of the nasal mucosa.

The therapeutic effect usually develops after 5-7 days of course use of beclomethasone.

When applied externally and locally, it has antiallergic and anti-inflammatory effects.

Pharmacokinetics

After inhalation administration, part of the dose that enters the respiratory tract is absorbed in the lungs. In lung tissue, beclomethasone dipropionate is rapidly hydrolyzed to beclomethasone monopropionate, which in turn is hydrolyzed to beclomethasone.

The portion of the dose that is inadvertently ingested is largely inactivated on first pass through the liver. In the liver, the process of converting beclomethasone dipropionate into beclomethasone monopropionate and then into polar metabolites occurs.

The binding of the active substance in the systemic circulation to plasma proteins is 87%.

With intravenous administration, half-life of beclomethasone 17,21-dipropionate and beclomethasone is approximately 30 minutes. Excreted up to 64% in feces and up to 14% in urine within 96 hours, mainly in the form of free and conjugated metabolites.

Release form, composition and packaging

Aerosol for inhalation, dosed in the form of a colorless or almost colorless solution, under pressure in an aluminum cylinder with a metering valve, equipped with a spray nozzle with a protective cap; At the exit of the cylinder, the drug is sprayed in the form of an aerosol jet.

Excipients : ethanol 96% - 2.1 mg, norflurane - 87.2 mg.

200 doses - aluminum cylinders (1) with a spray nozzle - cardboard packs.

Dosage regimen

When administered by inhalation, the average dose for adults is 400 mcg/day, frequency of use is once a day. If necessary, the dose can be increased to 1 g/day. For children, a single dose of kg, frequency of use is once a day.

When administered intranasally, the dose is 400 mcg/day, the frequency of use is 1-4 times/day.

For external and local use, the dose depends on the indications and the dosage form of the drug used.

Drug interactions

Side effect

From the respiratory system: hoarseness, feeling of irritation in the throat, sneezing; rarely - cough; in isolated cases - eosinophilic pneumonia, paradoxical bronchospasm, with intranasal use - perforation of the nasal septum. Candidiasis of the oral cavity and upper respiratory tract is possible, especially with long-term use, which resolves with local antifungal therapy without stopping treatment.

Allergic reactions: rash, urticaria, itching, erythema and swelling of the eyes, face, lips and larynx.

Effects caused by systemic action: decreased function of the adrenal cortex, osteoporosis, cataracts, glaucoma, growth retardation in children.

Indications

For inhalation use: treatment of bronchial asthma (including those with insufficient effectiveness of bronchodilators and/or sodium cromoglycate, as well as severe hormone-dependent bronchial asthma in adults and children).

For intranasal use: prevention and treatment of year-round and seasonal allergic rhinitis, including hay fever rhinitis, vasomotor rhinitis.

For external and local use: in combination with antimicrobial agents - infectious and inflammatory diseases of the skin and ear.

Contraindications for use

Use during pregnancy and breastfeeding

Contraindicated in the first trimester of pregnancy.

Use in the second and third trimesters of pregnancy is possible only when the expected benefit to the mother outweighs the potential risk to the fetus. Infants whose mothers received beclomethasone during pregnancy should be closely monitored for adrenal insufficiency.

If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.

Use in children

special instructions

Beclomethasone is not intended for the relief of acute asthmatic attacks. It should also not be used for severe asthma attacks requiring intensive care. The recommended route of administration for the dosage form used should be strictly followed.

Beclomethasone should be used with extreme caution and under close medical supervision in patients with adrenal insufficiency.

The transfer of patients who constantly take GCS orally to inhaled forms can be done only if their condition is stable.

If paradoxical bronchospasm is likely to develop, bronchodilators (for example, salbutamol) are inhaled before administering beclomethasone.

With the development of candidiasis of the oral cavity and upper respiratory tract, local antifungal therapy is indicated without stopping treatment with beclomethasone. Infectious and inflammatory diseases of the nasal cavity and paranasal sinuses, if appropriate therapy is prescribed, are not a contraindication for treatment with beclomethasone.

Preparations for inhalation containing 250 mcg of beclomethasone in 1 dose are not intended for children under 12 years of age.

Source: http://protabletky.ru/beclometasonum/

Reviews for Beclomethasone

Release form: Aerosol

Nastya added a neutral review

An effective remedy, BUT hormonal.

I never imagined that I would get asthma, it seemed to me that this was a congenital disease and that it had bypassed me, but unfortunately, at the age of 20, I found out that I was mistaken. The doctor prescribed me Beclomethasone. It turned out that this was a hormonal medicine, but there was nowhere to go. Moreover, the doctor consoled me by saying that taking it in small quantities is quite difficult to cause addiction. I started using the medicine, and after a while I forgot about difficulty breathing at night and in the cold (these were exactly the symptoms of my asthma). After 3 months, I became bolder and wanted to stop taking the drug, but that was not the case - after 3 days I again started having attacks at night. I had to return Beclomethasone to my life. I don’t know what to do if they stop producing it while I’m sitting on it.

Anna added a positive review to Beclomethasone

I have been using this spray since 2015, when I was diagnosed with bronchial asthma after suffering from the flu. I am glad that with this spray I can safely play sports and lead a full life. I use this spray once a day or less, since the drug is hormonal, I would not like to get used to it. Among the advantages I can highlight convenient packaging, ease of use, absence of odor and aftertaste. Once I didn’t use it for a week, and what made me happy was that I didn’t experience asthma attacks or difficulty breathing, since then I’ve been using it once a week, which is enough for my illness.

Dinara added a positive review to Beclomethasone

Relieves cough and shortness of breath

This drug was prescribed in the hospital due to shortness of breath and frequent coughing attacks. I first read about it online before I bought it, and I calmed down in advance. There are a lot of good reviews on Beclomethasone and I will add one more. Since I started using it, the cough has really stopped. And the problem with shortness of breath, one might say, has been resolved. Recently I had the opportunity to climb the stairs to the fifth floor without an elevator and I was able to cope with this test without having to then slide down the wall, trying to catch my breath.

Olga added a positive review to Beclomethasone

Rescue from a runny nose and from vasoconstrictor drugs

Beclamethasone is the active ingredient of a medicine with the trade name Nasobek (nasal spray). To relieve dependence on vasoconstrictors for a runny nose, I was prescribed Nasobek. It relieves congestion quickly, but where it works well, there must be a fly in the ointment - a hormonal drug. That is, you need to carefully let the body get used to it, then carefully let it get used to it. It is better to do an ultrasound of the thyroid gland first (the ENT specialist, of course, kept silent about this). My experience with taking it was short-lived - two weeks; when I opened the package, it remained unfinished. But there was an effect, the runny nose goes away almost instantly. I was treated for sinusitis for a month - a week on the antibiotic Agumentin, two weeks on vasoconstrictors, two on Beclomethasone (Nasobek).

Galya added a positive review to Beclomethasone

I felt like a full person again

Several years ago I was diagnosed with asthma and since then my life has not changed for the better. I often caught a cold, coughed, and lay in bed instead of doing work. Doctors advised me to buy Beclomethasone to stabilize my condition. You must understand that Beclomethasone is not some kind of magic drug that can relieve you of asthma. It only helps maintain the appearance that you are a healthy person. As long as you regularly use your inhaler, no one will ever guess that you are sick. You can even play sports if you want. And the inhaler is very easy to use, it is convenient and the product does not burn the throat.

. LekReviews.com / All information is presented for informational purposes only and cannot be used as a recommendation for treatment.

Source: http://lekotzyvy.com/preparat/b/beklometazon/

Beclomethasone: instructions for use, price and reviews

Beclomethasone is a glucocorticoid drug that affects the mucous membrane of the respiratory tract. The drug is used for the basic treatment of various forms of bronchial asthma, allergic rhinitis in children and adults.

According to experts, it is an effective anti-inflammatory and antiallergic agent for inhalation use. The results of using the drug become noticeable 5–7 days after the start of use.

Indications for use

Beclomethasone helps eliminate epithelial edema and hyperemia, reduces bronchial hyperactivity, improves external respiration and the general condition of patients, and has a bronchodilator effect.

The drug is prescribed for the treatment of diseases:

  • Bronchial asthma;
  • Prevention of allergic rhinitis during hay fever;
  • Inflammatory and infectious diseases of the ear;

Beclomezaton: instructions for use

For inhalation use: adults are prescribed 500 mcg twice a day or 250 mcg four times a day; children under 6 years old - pump up to four times.

For intranasal use in adult patients and children over 12 years of age, beclomesatone is prescribed 100 mcg 3-4 times a day in each nasal passage; children under 12 years of age - 50 mcg in each nasal passage (no more than 500 mcg per day) with the same frequency of use.

The exact regimen of use of the drug and the duration of the course of treatment are determined by the attending physician on an individual basis. According to doctors, the use of the drug is effective for treating patients of any age.

Contraindications

The use of beclomethasone is not recommended in the following cases:

  • severe attacks of bronchial asthma;
  • for pulmonary tuberculosis;
  • candidomycosis of the upper respiratory tract;
  • in the first trimester of pregnancy;
  • individual intolerance to the components included in the drug;
  • bronchitis of non-asthmatic origin and bronchospasms;
  • periodic nosebleeds;
  • children under 6 years old.

The drug is used with extreme caution in the presence of glaucoma, frequent viral and bacterial infections, osteoporosis, liver diseases, and hypothyroidism.

Beclomethasone: side effects

Violation of the dosage and non-compliance with beclomethasone instructions for use of the drug can cause a number of undesirable consequences.

Candidiasis of the oral cavity and pharynx. To reduce the side effect, it is necessary to rinse your mouth after using the drug and treat the spacer;

Skin rash, redness of the skin, hives and itching may occur. Some experience swelling of the mucous membrane of the lips of the eyes, angioedema, and an anaphylactic reaction to the drug.

On the part of the endocrine system, suppression of the function of the adrenal cortex, growth retardation in children, and the formation of glaucoma and cataracts can be observed.

In the case of systematic use of the drug, patients, according to doctors, complain of hoarseness and the appearance of bronchospasms. In this case, the instructions for use of the drug recommend immediately stopping the medication until further examination of the patient and the appointment of another drug.

With prolonged intranasal use of the drug, perforation of the nasal septum may occur. The use of beclomethasone can lead to thinning of the subcutaneous adipose tissue and the formation of bruises on the skin.

Beclomethasone: release form

The drug beclomethasone aerosol is dispensed in a pharmacy with a doctor's prescription. The drug is an aerosol packaged in sealed aluminum containers with a metering valve with a spray and a protective cap, 200 doses each. The cylinder dosage is 50 mcg/dose, 100 mcg/dose, or 250 mcg/dose.

special instructions

When prescribing a drug, it is necessary to familiarize the patient with the instructions for its use, which will ensure complete penetration of the drug into the upper respiratory tract and areas of the lungs.

The development of candidiasis in some patients may be associated with a previous fungal infection and a high level of antibodies in the blood against the fungal infection. In this case, patients are prescribed topical drugs against fungal infections, which are used in conjunction with beclomesatone.

Instructions for using the inhaler

To effectively use the drug, special dispensers are used - spacers, which distribute the drug into the lung tissue and prevent the occurrence of side effects.

When using the drug, you must follow the safety rules:

  • protect your eyes to avoid contact with the medicine;
  • The used cylinder must not be punctured, heated or disassembled. When using the drug at low temperatures, it is recommended to first heat the balloon in your hands, after removing the nozzle from it.
  • Before the first use, you must check the operation of the can. To do this, you need to remove the protective cap, turn the bottle upside down, shake it several times and make several presses until a stream of medicine appears.
  • If the drug beclomesatone is used regularly, the following procedure should be followed:
  • remove the protective cap from the nozzle. Make sure that it is free of dust and dirt;
  • hold the bottle vertically upside down. Place your index finger on the bottom of the container, and your thumb on the inhaler nozzle. Shake the can several times;
  • Exhale deeply and pinch the nozzle tube with your lips;
  • while taking a slow, deep breath, press the nozzle and release a dose of medication while continuing to inhale slowly;
  • hold your breath for a few seconds and exhale slowly;
  • if more than one dose of the drug is needed, repeat the procedure after one minute.

The inhaler nozzle requires periodic cleaning. Once a week it must be washed in warm water, after removing it from the can. Heating devices should not be used for drying.

Interaction with other drugs

When beclomesatone aerosol is used together with other glucocorticoid drugs, it is possible to suppress the function of the adrenal cortex.

Beclomethasone analogues

Direct analogues of the drug containing beclomethasone as an active substance are Beclat, Beklospira, Klenil, Eco Easy Breathing, Beclomesaton-aeronativ.

Topical glucocorticoid drugs have a similar therapeutic effect: Asmanex Twistheiler, Benacort, Budecort, Budenit Steri-Neb, Pulmicort, Tafen Novolizer, Flixotide, Alvesco.

According to reviews from doctors and patients, beclomethasone analogues are not inferior in providing therapeutic effects and are affordable.

Beclomesaton price

You can purchase the drug beclomethasone at a pharmacy with a prescription from your doctor. The price for beclomethasone nasal aerosol ranges from 130 to 300 rubles, depending on the number of doses.

The price of an inhalation aerosol is from 250 rubles.

Reviews

To treat bronchospasm and shortness of breath, the doctor prescribed beclomethasone. After six months of use, the dose was reduced. Shortness of breath appears very rarely, but I continue to take the medicine. The drug is distinguished by a convenient release form and an affordable price.

Beclomethasone aeronative was used for a year to relieve attacks of bronchial asthma. The medicine was received at the clinic using a preferential prescription. Currently there are no problems with asthma.

About a year ago I started using beclomethasone for asthma attacks in cold air. After 4 months the dose was reduced. Currently I am no longer taking the drug.

I was prescribed beclomethasone after pneumonia and exacerbation of bronchial asthma. The drug helped with complex treatment. A good and effective product.

Source: http://lekarstva.guru/b/beklometazon-instruktsiya-po-primeneniyu-tsena-i-otzyvy.html

Beclomethasone analogues price reviews instructions for use

Beclomethasone instructions for use

pharmachologic effect

Beclomethasone is a local glucocorticosteroid that has anti-inflammatory and antiallergic effects. Inhibits the release of inflammatory mediators, increases the production of lipocortin (annexin), an inhibitor of phospholipase A2, which leads to a decrease in the formation of arachidonic acid and its transformation products.

Reduces inflammation by reducing the formation of chemotaxis substance (this explains the effect on “late”

allergy reactions), inhibits the development of an “immediate” allergic reaction (due to inhibition of production

metabolites of arachidonic acid and a decrease in the release of inflammatory mediators from mast cells) and improved

There is mucociliary transport. Under the influence of beclomethasone, the number of mast cells in the mucous membrane decreases.

nasal cavity, marginal accumulation of neutrophils, inflammatory exudate and cytokine production, inhibited

migration of macrophages, the intensity of infiltration and granulation processes decreases, which plays a significant role in the development of allergic rhinitis.

In therapeutic doses, it has an active local effect without the development of side effects characteristic of systemic glucocorticosteroids.

The therapeutic effect develops gradually, usually after 5–7 days of course use of beclomethasone dipropinate; in some patients, after 2–3 weeks.

Indications

For inhalation use: treatment of bronchial asthma (including those with insufficient effectiveness of bronchodilators and/or sodium cromoglycate, as well as severe hormone-dependent bronchial asthma in adults and children).

For intranasal use: prevention and treatment of year-round and seasonal allergic rhinitis, including hay fever rhinitis, vasomotor rhinitis.

For external and local use: in combination with antimicrobial agents - infectious and inflammatory diseases of the skin and ear.

Contraindications

Hypersensitivity, ulceration of the nasal septum, recent surgical interventions in the nasal cavity, non-

long-standing nasal injury, childhood (up to 6 years).

Use during pregnancy and breastfeeding

Contraindicated in the first trimester of pregnancy.

Use in the second and third trimesters of pregnancy is possible only when the expected benefit to the mother outweighs the potential risk to the fetus. Infants whose mothers received beclomethasone during pregnancy should be closely monitored for adrenal insufficiency.

If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.

special instructions

Before prescribing inhaled drugs, it is necessary to instruct the patient about the rules for using the drug to ensure the most complete delivery of the drug to the desired areas of the lungs.

Beclomethasone is not intended for the relief of acute attacks of bronchial asthma. Patients should be aware of the preventive nature of the drug and that to achieve optimal effect, the inhaler should be used regularly, even in the absence of symptoms of bronchial asthma.

With regular inhalation of beclomethasone, improvement in breathing usually occurs after 1 week of treatment. Lack of effect is possible in patients with increased levels of sputum and mucus in the respiratory tract and severe bronchospasm, which prevents the drug from reaching the zone of action. In such cases, inhalation of beta-agonists is prescribed before inhalation of beclomethasone or treatment is started with the systemic use of corticosteroids.

The transfer of patients regularly taking oral corticosteroids to inhaled beclomethasone, as well as subsequent treatment, should be carried out with extreme caution, under daily monitoring of external respiration function, since the suppression of the adrenal cortex caused by long-term use of corticosteroids is restored slowly.

Before prescribing inhaled forms of beclomethasone, patients should be in a relatively stable condition, and their prescription itself should complement the usual maintenance dose of systemic corticosteroids. After about 1 week, the daily dose of steroids begins to be gradually reduced - 1 mg/week (in terms of prednisolone). Deterioration of the condition against the background of a maintenance dose of 400 mcg/day means the need to transfer patients to oral prednisolone. Regular use allows in most cases to cancel oral corticosteroids (patients who need to take no more than 15 mg of prednisolone can be completely transferred to inhalation therapy), while in the first months after the transition the patient’s condition should be carefully monitored until his hypothalamic-pituitary-adrenal the system will not recover sufficiently to respond to stressful situations (such as injury, surgery, or infection).

Patients transferred to inhalation treatment and having impaired function of the adrenal cortex should have a supply of GCS and a warning card, which should indicate that in stressful situations they need additional systemic use of GCS (after eliminating the stressful situation, the dose of steroids can be reduced again ). Sometimes a transfer from taking systemic corticosteroids to inhalation administration can lead to the manifestation of previously suppressed forms of allergies, for example, allergic rhinitis or eczema.

It is necessary to protect the eyes from contact with the drug.

It is advisable to rinse the mouth and throat after inhalation (prevention of candidiasis), and when initial signs of fungal infection of the oral mucosa appear, use antifungal agents. By washing after inhalation you can prevent damage to the skin of the eyelids and nose.

The maximum daily dose of the drug in adults should not exceed 1 mg. At a dose of up to 1.5 mg/day in most patients, it does not significantly suppress adrenal function. If this dose is exceeded, some patients may experience some suppression of adrenal function. Treatment in doses of more than 1 mg/day is carried out under the supervision of a physician.

During pregnancy and breastfeeding, beclomethasone should be used with caution and only if the benefit to the mother outweighs the potential risk to the fetus. There is insufficient data on the safety of beclomethasone in pregnant women and on its penetration into breast milk.

Beclomethasone preparations containing 1 dozemkg play an important role in the treatment of severe forms of bronchial asthma in children, since they provide good control over the course of the disease and do not cause growth retardation in the child. Beclomethasone 250 mcg is not intended for use in pediatrics. It is recommended to regularly monitor the growth dynamics of children receiving inhaled corticosteroids over a long period of time.

Infectious and inflammatory diseases of the respiratory system are not a specific contraindication for treatment with beclomethasone.

Directions for use and doses

Adults (including elderly patients) and children over 12 years of age: 1-2 dosed sprays (50-100 mcg) into each nasal passage 2 times a day (200-400 mcg per day).

Maximum daily dose – 8 doses (400 mcg)

Children aged 6 to 12 years: the initial dose is 50 mcg (1 dosed spray), if necessary - 100 mcg (2 dosed sprays) 2 times a day in each nasal passage. The maximum daily dose is 400 mcg.

Divide the daily dose into 2–4 doses.

Once the therapeutic effect is achieved, the drug is discontinued, gradually reducing the dose.

Side effects

Hoarseness, irritation in the throat, coughing, sneezing; paradoxical bronchospasm (relieved by the administration of inhaled bronchodilators), eosinophilic pneumonia; allergic reactions, candidiasis of the oral cavity and upper respiratory tract (with long-term use and/or when used in high doses - more than 400 mcg/day), which occurs with local antifungal therapy without stopping treatment.

With long-term use in doses of more than 1.5 mg/day - systemic side effects (including adrenal insufficiency), headaches, dizziness, cataracts, increased intraocular pressure, leukocytosis, lymphopenia, eosinopenia.

With a single inhalation of high doses of beclomethasone dipropionate (more than 1 mg), a slight decrease in the function of the hypothalamic-pituitary-adrenal system is possible, which does not require any emergency measures, and treatment should be continued. The function of the hypothalamic-pituitary-adrenal system is restored after 1-2 days.

Drug interactions

No significant interactions of inhaled corticosteroids with other drugs were identified.

Beclomethasone restores the patient's response to beta-agonists, making it possible to reduce the frequency of their use.

Phenobarbital, phenytoin, rifampicin and other inducers of microsomal liver enzymes reduce effectiveness.

Methandienone, estrogens, beta2-agonists, theophylline and systemic corticosteroids enhance the effect.

Increases the effect of beta-agonists.

Overdose

Storage conditions

Store at a temperature not exceeding +25 C.

Best before date

Compound

Active substance: 0.25 mg dipropionate.

Excipients: polysorbate 80, dextrose, microcrystalline cellulose, benzalkonium chloride, solution

sodium hydroxide (1M) or hydrochloric acid solution (1M), purified water.

Beclomethasone analogues

Beclomethasone ds 250 µg/dose 200 doses aerosol

Price, rub.

Beclomethasone Orion spray 50 mcg/dose, 200 doses

Price, rub.

Beclomethasone Orion spray 50 mcg/dose, 200 doses

Price, rub.

Beclomethasone Orion Pharma nasal spray. dosage 50mcg/dose vial. 200 doses 23 ml No. 1

Price, rub.

Beclomethasone-aeronativ 100 µg/dose 200 doses aer d/ing

Price, rub.

Beclomethasone-aeronativ aer. d/ing. dosed 100 mcg/dose 200 doses No. 1 (balloon with spray nozzle for dosing)

Price, rub.

Beclomethasone-aeronativ 250 µg/dose 200 doses aer d/ing

Price, rub.

Beclomethasone-aeronativ 50 µg/dose 200 doses aer d/ing

Price, rub.

Beclomethasone-aeronativ aer. d/ing. dosage 50 mcg/dose 200 doses No. 1 (balloon with spray nozzle dosing

Price, rub.

Beclomethasone Orion Pharma spr. called dosage 100 mcg/dose vial. 23 ml (200 doses) No. 1

Price — 83 rub.

Beclomethasone Orion spray 50 mcg/dose, 200 doses

Price, rub.

Beclomethasone Orion spray 100 mcg/dose, 200 doses

Price - 84 rub.

Beclomethasone-aeronativ aer d/ingal doser 50 mcg/dose 200 doses score al

Price, rub.

Beclomethasone-aeronative aerosol for inhalation 50 mcg/dose, 200 doses

Price, rub.

Forest balm toothpaste with ex. black currant and linden tube 100ml Russia

Price, rub.

pharmachologic effect

Flosterone is a glucocorticosteroid drug (GCS). It has anti-inflammatory, antirheumatic and antiallergic effects. Betamethasone disodium phosphate is an easily soluble component that is quickly absorbed into tissues and provides a quick effect. Prolonged (long-lasting) action is provided by betamethasone dipropionate, which has a slower absorption (absorption). Depending on the method of application: intramuscularly (intramuscular), intraarticular (intra-articular), periarticular (into the space surrounding the joint), intradermal (intradermal) - a general or local effect is achieved.

Indications

Flosterone is intended for the treatment of severe acute and chronic conditions that require the use of corticosteroids. Rheumatic diseases - rheumatoid arthritis (an infectious-allergic disease from the group of collagenoses, characterized by chronic progressive inflammation of the joints), extra-articular rheumatism (synovitis /inflammation of the inner lining of the joint/, epicoshlit /inflammation of a limited area of ​​the humerus, which is the site of attachment of muscles and tendons/, tenosynovitis / combined inflammation of the tendon and inner lining of the joint/, myositis /inflammation of muscles/, fibrositis /inflammatory change in connective tissue fibers/, lumbago /paroxysmal intense pain in the lumbar region/, psoriatic arthritis /inflammation of the joint in psoriasis/, post-traumatic osteoarthritis /inflammatory disease of the joint with damage to the articular ends of articulating bones due to mechanical trauma / etc.). Allergic diseases - bronchial asthma, seasonal or chronic rhinitis (inflammation of the nasal mucosa); skin diseases - psoriasis, keloid (overgrowth of connective tissue of the skin), alopeciaareata (partial hair loss), contact atonic dermatitis (neuroallergic inflammation of the skin, characterized by itching and multiple skin rashes located on symmetrical areas of the body, due to direct exposure to a damaging factor / physical, chemical etc./), insect bites, collagenosis (a general name for diseases characterized by diffuse damage to connective tissue and blood vessels) and other hypersensitivity reactions. Ulcerative colitis (inflammation of the colon with the formation of ulcers).

Contraindications

Tuberculosis, osteoporosis, various psychoses, peptic ulcer (ulcer of the stomach, intestines or esophagus, developed as a result of the destructive effect of gastric juice on the mucous membrane), glaucoma (increased intraocular pressure), diabetes, thrombophlebitis (inflammation of the wall of the veins with their blockage), bacterial, fungal or viral infections, renal failure, Cushing's syndrome (obesity accompanied by decreased sexual function, increased bone fragility due to increased release of adrenocorticotropic hormone from the pituitary gland). Vaccination and immunization are contraindicated while using the drug.

It is not recommended to prescribe flosterone during pregnancy and breastfeeding.

special instructions

Flosteron suspension cannot be administered intravenously

Intra-articular and periarticular administration should be carried out by a specially trained specialist.

When using the drug topically, in all cases it is necessary to evaluate its compatibility with simultaneously administered local anesthetics. It is allowed to mix with an equal volume of solutions of local anesthetics (1% solution of procaine hydrochloride or 1% solution of lidocaine hydrochloride) in a syringe, but not in an ampoule.

It should not be used for the treatment of hyaline membrane disease of newborns, or injected into infected areas and intervertebral spaces.

With local (intra-articular) administration of GCS, both local and systemic effects are possible.

Before and during steroid therapy, it is necessary to monitor a general blood count, glycemia and glucosuria, and the content of electrolytes in the blood plasma.

An appropriate study of the synovial fluid in each joint is necessary to exclude a septic process. A significant increase in pain, accompanied by local swelling, further limitation of joint mobility, fever and malaise, suggests septic arthritis. If the diagnosis of sepsis is confirmed, appropriate antimicrobial therapy is necessary. When treating during intercurrent infections, septic conditions, tuberculosis, antibiotic treatment is carried out simultaneously.

It should not be injected into “unstable” joints, in the area of ​​the Achilles tendon, due to the risk of rupture of this tendon.

Vaccination with live viral vaccines is contraindicated during GCS therapy. Immunization with killed viral or bacterial vaccines during the use of GCS does not provide the expected increase in the number of antibodies and does not provide the expected protective effect. Therefore, such drugs should not be prescribed 8 weeks before and 2 weeks after vaccination.

In patients who have not had chickenpox and are receiving treatment with corticosteroids, the risk of developing chickenpox or herpetic infection increases due to accidental contact with infected persons. In such cases, passive immunization is recommended.

Caution is necessary in patients after surgery and bone fractures, since GCS can slow down the healing of wounds and fractures.

The effect of GCS is enhanced in patients with liver cirrhosis or hypothyroidism.

When using Flosteron against the background of arterial hypertension, heart failure, diabetes mellitus, epilepsy, thromboembolism, myasthenia gravis, glaucoma, hypothyroidism and severe liver damage, the risk of hypokalemia increases.

The use of Flosteron may alter the performance of hypersensitivity tests.

In children during the growth period, GCS should be used only according to absolute indications and under the particularly careful supervision of the attending physician.

In patients with acute and subacute myocardial infarction, the necrosis focus may spread, the formation of scar tissue may slow down, and, as a result, the heart muscle may rupture.

Metabisulfites in patients with bronchial asthma or a history of allergies can cause allergic reactions, including anaphylaxis and bronchospasm.

0.6 mg betamethasone is equivalent to 0.75 mg dexamethasone, 4 mg triamcinalone, 4 mg methylprednisolone and 20 mg hydrocortisone (according to AMA, 1994).

The influence of Flosteron on the ability to drive vehicles and operate machinery

During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Directions for use and doses

The dosage of flosterone depends on the severity of each individual disease, as well as on the clinical picture.

Systemic use: to achieve a systemic effect, the drug is administered intramuscularly deep into the gluteal region in a dose of 1.0 to 2.0 ml every 2-4 weeks.

Topical application: apply doses of 0.25 to 2.0 ml, depending on the size of the affected area, every 2-4 weeks.

Intraarticular and periarticular. pelvic joints - from 1.0 to 2.0 ml, knee, ankle, shoulder joints - 1.0 ml; elbow joint, wrist - from 0.5 to 1.0 ml; sternoclavicular, metacarpophalangeal, interphalangeal joints - from 0.25 to 0.5 ml.

Injection of the drug directly into the lesion (intradermal /intradermal/, not subcutaneously!): psoriasis, alopeciaareata/partial hair loss/, coin-like eczema (inflammation of the papillary layer of skin caused by microbes, in which the inflammation foci have a round shape), neurodermatitis (disease skin, caused by dysfunction of the central nervous system), etc. Doses should not exceed 0.2 ml/cm, and the weekly dose should not be more than 1 ml. If necessary, flosterone can be mixed in an injection syringe with a local anesthetic (1% procaine or 1% lidocaine).

Side effects

With long-term use of the drug - weight gain, neuroses, edema, deterioration of the condition in diabetics, osteoporosis (malnutrition of bone tissue, accompanied by an increase in its fragility).

Drug interactions

The combined use of Flosteron with NSAIDs and ethanol increases the risk of gastrointestinal bleeding and ulcer formation.

Increases the risk of hepatotoxicity of paracetamol.

The effectiveness of betamethasone is reduced if it is administered concomitantly with rifampicin, carbamazepine, phenobarbital, phenytoin (diphenylhydantoin), primidone, ephedrine and aminoglutethimide.

Increase the risk: antipsychotic drugs, immunosuppressants (increased likelihood of developing infection, as well as lymphomas and other lymphoproliferative diseases), carbutamide, azathioprine (cataracts), M-anticholinergic drugs, antihistamines, tricyclic antidepressants, nitrates (increased intraocular pressure), Digitalis glycosides (arrhythmias associated with hypokalemia).

GCS reduce the therapeutic effect of antidiabetic drugs, antihypertensive drugs, anticoagulants (coumarin and indandione derivatives and natriuretics.

Reduces the effectiveness of anticoagulants (including heparin, streptokinase and urokinase), albendazole and kaliuretics.

With the simultaneous use of GCS in high doses and beta2-agonists, the risk of developing hypokalemia increases.

GCS increase the renal clearance of salicylates, and therefore, against the background of their action, it is sometimes difficult to achieve a therapeutic concentration of salicylates in the blood serum.

When taken simultaneously with androgens, estrogens, anabolic steroids, oral contraceptives, T1/2 GCS may be prolonged, their effect may be enhanced, and the frequency of side effects (hirsutism, acne) may increase.

The combined use of ritodrine and corticosteroids is contraindicated, since with such a combination the development of pulmonary edema is possible.

When Flosteron is used simultaneously with live antiviral vaccines and against the background of other types of immunization, the risk of viral activation and the development of infections increases.

Reduces the concentration of praziquantel in the blood serum.

Amphotericin B and carbanhydrase inhibitors increase the risk of osteoporosis.

Increases the toxicity of asparaginase (possibly increasing its hypoglycemic effect and the risk of developing neuropathy and impaired erythropoiesis).

Reduces the metabolism of cyclosporine, increasing its toxicity.

Increases (with long-term use) the content of folic acid. Increases the metabolism of isoniazid, mexiletine (especially in “fast acetylators”), which leads to a decrease in their plasma concentrations.

Mitotane and other inhibitors of adrenal function may necessitate increasing doses of GCS.

Hypokalemia caused by GCS can increase the severity and duration of muscle blockade due to muscle relaxants.

Reduces the effect of somatotropin.

Increases the severity of the hyperglycemic effect of streptozocin.

Overdose

Symptoms: nausea, vomiting, sleep disorders, euphoria, agitation, depression. With long-term use in high doses - osteoporosis, fluid retention in the body, increased blood pressure, myopathy, Itsenko-Cushing syndrome, suppression of the function of the adrenal cortex. The effects of an overdose may last for several weeks.

Treatment: in such cases, the dose must be reduced until the drug is gradually discontinued and symptomatic treatment, maintenance of vital functions, correction of electrolyte balance, antacids, phenothiazines, lithium preparations must be carried out. For Itsenko-Cushing syndrome - aminoglutethimide. There is no specific antidote. Hemodialysis is not effective.

Storage conditions

In a cool place, protected from light.

Compound

1 ampoule (1 ml) contains 2 mg of betamethasone phosphate in the form of disodium salt and 5 mg of betamethasone dipropionate.

Diprospan Susp d/in 2mg+5mg/ml 1ml n5 amp

Price, rub.

pharmachologic effect

Diprospan - antiallergic, anti-inflammatory.

Inhibits the release of interleukins 1 and 2, interferon gamma from lymphocytes and macrophages, inflammatory mediators (eosinophils); induces the formation of lipocortins; reduces the metabolism of arachidonic acid.

Betamethasone disodium phosphate (easily soluble component) is rapidly absorbed and provides a rapid onset of effect. Betamethasone dipropionate, which has a slower absorption, provides a prolonged effect.

Indications

  • rheumatoid arthritis, extra-articular rheumatism (synovitis, epicondylitis, tenosynovitis, myositis, fibrositis);
  • osteoarthritis, traumatic arthritis, osteochondrosis, acute gouty arthritis;
  • lumbago;
  • bronchial asthma;
  • allergic acute and chronic rhinitis;
  • psoriasis;
  • keloid scars;
  • alopecia areata;
  • contact atopic dermatitis;
  • nonspecific ulcerative colitis.

Contraindications

  • peptic ulcer of the stomach and/or duodenum;
  • osteoporosis;
  • Itsenko-Cushing's disease;
  • diabetes;
  • thrombophlebitis;
  • viral, fungal, bacterial infections;
  • active form of tuberculosis;
  • glaucoma;
  • psychosis;
  • diverticulitis;
  • condition after a recent operation to perform intestinal anastomosis;
  • vaccination period;
  • hypersensitivity to the drug.

Use during pregnancy and breastfeeding

Diprospan is not used during pregnancy.

If it is necessary to use Diprospan during lactation, it is recommended to stop breastfeeding.

special instructions

It is not recommended to administer Diprospan inside joints in case of habitual dislocation.

With long-term use of the drug, the level of glucose in the blood plasma should be monitored.

Directions for use and doses

IM, deep into the gluteal region, 1–2 ml, for various dermatological diseases.

Intra-articular and periarticular - from 0.25 to 2 ml, depending on the size of the joint.

IV (into the lesion), single dose - up to 0.2 ml/cm2 (no more than 1 ml per week). Local infiltration: for bursitis - 0.25 to 1 ml (for acute form - up to 2 ml), for synovial cyst and tenosynovitis - from 0.25 to 0.5 ml, for tendonitis - 0.5 ml, for myositis, fibrositis - from 0.5 to 1 ml. If necessary, it can be mixed in a syringe with local anesthetics (1% procaine solution or 1% lidocaine solution).

Side effects

From the central nervous system: sleep disturbances, agitation, depression, anxiety syndrome, polyphagia, neuroses.

Metabolic: weight gain, osteoporosis, growth retardation in children.

Other: secondary infection.

Drug interactions

When Diprospan is used simultaneously with NSAIDs, the risk of erosive and ulcerative lesions and bleeding from the gastrointestinal tract increases.

Storage conditions

Store at temperatures between 2 and 25°C.

Best before date

Compound

1 ml of solution contains:

Active ingredients: 2 mg disodium phosphate; 5 mg dipropionate.

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reviews

I was prescribed beclomethasone aeronative for the treatment of COPD. They immediately gave me a larger dose, but it became much better. I still take it, but the dose has now been significantly reduced, we’ll see what the doctor says next.

I used beclomethasone-aeronative for about a year in the treatment of asthma. After about half a year, the doctor reduced the dosage. There was no shortness of breath or cough. I haven't used it for a year now.

You helped me. Thankful.

We were prescribed beclomethasone-aeronativ at the end of 2013. Once the doctor increased the dosage for about 3 months. We haven’t used it since January, so far everything is normal, but I still take it with me, just in case.

Source: http://apteka.nawideti.info/analogi/beklometazon-analogi-cena-otzyvy-instrukciya-po-primeneniyu