Beclomethasone ointment

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Beclometasone + Clotrimazole (Beclometasone + Clotrimasole)

Content

Russian name

The Latin name of the substances is Beclomethasone + Clotrimazole

Pharmacological group of substances Beclomethasone + Clotrimazole

Typical clinical and pharmacological article 1

Pharmaceutical action.

Table of contents:

Combined preparation for external use. Beclomethasone - GCS, has anti-inflammatory, antiallergic, antiexudative, antipruritic effects. Clotrimazole is a broad-spectrum antifungal agent that disrupts the synthesis of ergosterol, which is part of the cell membrane of fungi, which causes a change in its structure and properties and leads to cell lysis. Dermatophytes, yeast fungi (genus Candida, Torulopsis glabrata, genus Rhodotorula) , mold fungi, pathogens of pityriasis versicolor and erythrasma, gram-positive (staphylococci and streptococci) and gram-negative (Bacteroides, Gardnerella vaginalis) bacteria, Trichomonas vaginalis, Malassezia furfur, Corynebacterium are sensitive to clotrimazole minutissimum.

Indications. Fungal infections of the skin caused by sensitive microorganisms (including ringworm, athlete's foot, dermatosis complicated by secondary infection), especially against the background of eczematous lesions.

Contraindications. Hypersensitivity, skin tuberculosis, chicken pox, measles, herpes, vaccination, syphilitic skin rashes.

Dosing. Externally, the cream is applied to the affected area 2-3 times a day and lightly rubbed. The previously affected area is washed and dried.

Side effect. Local reactions - skin hyperemia, burning and tingling sensation, allergic reactions; when using occlusive dressings - rash, folliculitis, pyoderma.

Special instructions. The drug is intended for use only in dermatological practice.

If irritation occurs, the drug is discontinued.

During pregnancy and lactation, it should not be used on large areas of the skin or for a long period of time.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

[1] State register of medicines. Official publication: in 2 volumes - M.: Medical Council, 2009. - T.2, h.s.; h.s.

Interactions with other active ingredients

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Beclomethasone

Description current as of 01/12/2015

  • Latin name: Beclometasonum
  • ATX code: R01AD01
  • Active ingredient: Beclometasone (beclometasone)
  • Manufacturer: Orion Corporation Orion Pharma (Finland)

Compound

The product contains the active component beclomethasone dipropionate.

Release form

The release form of this product is a dosed aerosol. The aerosol is produced in different volumes: a 9 ml bottle holds 70 doses, a 10 ml bottle holds 80 doses, a bottle 23 ml doses. Contained in polyethylene bottles with a pump dispenser, the kit also includes a spray nozzle. The bottle and nozzle are placed in a cardboard box.

pharmachologic effect

Beclomethasone provides anti-inflammatory, anti-allergic, decongestant, anti-asthmatic, anti-exudative effect.

There is pronounced glucocorticoid activity of the drug, as well as weak mineralocorticoid activity.

The drug increases the production of lipomodulin, reduces the release of arachidonic acid and reduces the synthesis of prostaglandins. Due to a decrease in the production of inflammatory exudate and lymphokines, the migration of macrophages is inhibited and the processes of granulation and infiltration slow down. As a result of its influence, the basement membrane of the epithelium thickens, the process of mucus secretion by goblet cells slows down, and the number of mast cells in the bronchial mucosa decreases. The active ingredient relaxes the smooth muscles of the bronchi and promotes the active restoration of its sensitivity.

The drug allows you to restore the body's response to bronchodilators, and, as a result, reduce the frequency of their use. The medicine improves external respiratory function indicators. If the drug is used in therapeutic doses, side effects that are typical for systemic corticosteroids are not observed.

If the medicine is used intranasally, hyperemia and swelling of the nasal mucosa are eliminated.

Pharmacokinetics and pharmacodynamics

The active substance after intranasal use is absorbed through the nasal mucosa. There is a low level of absorption from the gastrointestinal tract.

Systemic absorption occurs regardless of the form of administration. 87% bound to plasma proteins. The main part leaves the body through the intestines, about 15% is excreted through the kidneys.

The therapeutic effect is observed 4–5 days after the start of therapy, its maximum is observed over several weeks.

After administration by inhalation, part of the dose is absorbed in the lungs. The bulk of the dose that enters the digestive system is inactivated during the “first pass” process through the liver.

Indications for use

The use of the drug by inhalation is indicated for bronchial asthma (as a basic treatment). It is also used in case of insufficient effectiveness of ketotifen, bronchodilators, cromoglycic acid, in order to be able to reduce the dose of oral GCs.

Intranasal use is advisable for allergic rhinitis, both seasonal and permanent. It is also practiced to prescribe the drug for recurrent nasal polyposis and vasomotor rhinitis.

Local and external use of Beclomethasone is practiced in combination with antimicrobial drugs for infectious and inflammatory diseases of the skin and ear.

Contraindications

This drug should not be used in the following cases:

Inhalation use is not practiced:

Intranasal use is not practiced:

  • with hemorrhagic diathesis;
  • for systemic infections (bacterial, fungal);
  • with acute respiratory infections;
  • with frequent nosebleeds;
  • with herpetic eye lesions.

Please note that there are restrictions for intranasal use. These include recent surgical interventions in the nasal cavity, ulceration of the nasal septum, recent trauma to the nose, glaucoma, amebiasis, hypothyroidism, and severe liver failure. The drug should be used with caution if you have recently suffered a myocardial infarction.

Side effects

The following side effects are possible during inhalation:

  • sore throat;
  • hoarseness;
  • cough and sneezing;
  • eosinophilic pneumonia;
  • paradoxical bronchospasm;
  • allergic manifestations;
  • with long-term treatment - candidiasis of the oral cavity and upper respiratory tract (takes place with antifungal treatment, and there is no need to stop therapy).

Systemic side effects may occur when taking the drug in large doses (more than 1.5 mg per day).

When used intranasally, the following side effects are possible:

  • irritation and dryness of the nasal mucosa;
  • pain in the throat and nasal cavity;
  • nose bleed;
  • nasopharyngeal infections caused by fungal flora;
  • perforation of the nasal septum;
  • rhinorrhea;
  • ulceration of the nasal mucosa.

If prolonged use of the drug in large doses (more than 1500 mcg per day) is practiced, systemic side effects may develop.

Instructions for use of Beclomethasone (Method and dosage)

Instructions for use of Beclomethasone include intranasal and inhalation use of the drug. To get pronounced results, you should use the product regularly.

The dosage for inhalation use depends on the characteristics of the disease. Children should receive a lower dose than adults.

If a form of medication is used that contains 50 or 100 mcg of beclomethasone in 1 dose, adults should receive 100 mcg 3-4 times a day. If necessary, the dose is increased domkg. Children should receive pomkg twice a day.

If a form of the drug is used that contains 250 mcg of active ingredient per dose, adult patients receive 500 mcg twice daily or 250 mcg four times daily. If necessary, the dose is increased to mcg per day.

For intranasal use, 50 mcg is administered into each nasal passage 2-4 times a day.

Overdose

In case of overdose, signs of hypothalamic-pituitary-adrenal insufficiency appear. In this case, the patient is transferred to systemic glucocorticoids for some time, and ACTH is prescribed.

Interaction

When taken simultaneously, the effect of beta-agonists is enhanced. In turn, beta-agonists enhance the anti-inflammatory effect of Beclomethasone, increasing the degree of its penetration into the distal bronchi.

Ephedrine activates the metabolism of beclomethasone.

The effectiveness of Beclomethasone is reduced by inducers of microsomal oxidation enzymes.

When taken together, estrogens, methandienone, theophylline, beta2-adrenergic agonists, and oral glucocorticoids activate the effect of beclomethasone.

Terms of sale

Can be purchased with a prescription.

Storage conditions

Beclomethasone should be stored in a dark place, keeping the temperature below +30 °C.

Best before date

You can store it for 3 years, after opening the bottle can be stored for no more than 6 months.

special instructions

This drug should not be used to relieve acute asthma attacks. If an acute attack of bronchial asthma develops in response to the use of Beclomethasone, this treatment should be discontinued immediately.

If the patient has symptoms of hypothalamic-pituitary-adrenal insufficiency, the patient can continue inhalations, but strict control of the level of basal cortisol in plasma is required.

Similarly, these indicators should be monitored if large doses of beclomethasone are used for treatment.

If the patient has moderate or severe broncho-obstructive syndrome, bronchodilators should be used approximately 20 minutes before inhalation.

Avoid getting the product into your eyes.

When treating allergic rhinitis with severe symptoms, the effectiveness of the drug increases if it is used simultaneously with vasoconstrictors. To reduce the risk of developing oropharyngeal candidiasis, it is advisable to inhale before meals and rinse your mouth after each inhalation.

People with steroid-dependent asthma need to use higher doses of the drug.

Patients with asthma should switch from systemic glucocorticoids to inhaled Beclomethasone gradually. Do not sharply reduce the dose.

Beclomethasone analogs

For children

Beclomethasone for use by inhalation, which contains 250 mcg of active substance in one dose, should not be used to treat children under 12 years of age.

During pregnancy and lactation

The product should not be used for the treatment of pregnant women in the first trimester. In the second and third trimesters, the medicine can be used only when the expected benefit exceeds the expected level of risk. Those children who were born to mothers who received Beclomethasone during pregnancy should be examined for adrenal insufficiency. Breastfeeding should be stopped during treatment.

Reviews about Beclomethasone

Reviews about this medicine indicate that in most cases they can alleviate the condition of patients. There is evidence of some side effects, but overall reviews of the drug are positive.

Beclomethasone price, where to buy

The price of Beclomethasone averages rubles per bottle of 200 mcg.

  • Online pharmacies in Russia Russia

ZdravZone

Education: Graduated from Rivne State Basic Medical College with a degree in Pharmacy. Graduated from Vinnitsa State Medical University named after. M.I. Pirogov and internship at his base.

Work experience: From 2003 to 2013 – worked as a pharmacist and manager of a pharmacy kiosk. She was awarded diplomas and decorations for many years of conscientious work. Articles on medical topics were published in local publications (newspapers) and on various Internet portals.

Beclomethasone aeronative was prescribed for the treatment of bronchial asthma about six months ago. After 3 months, the doctor reduced the dose. Shortness of breath occurs rarely. I continue to receive.

I received beclamethasone aeronative at a discounted rate at the clinic and took it for about a year. The dose was reduced. No asthma problems since then

A year and a half ago, severe shortness of breath appeared, even to the point of suffocation from strong work or in the cold. The pulmonologist prescribed beclomethasone-aeronativ. He said that it was a reliable Russian drug; he took it with me every day, the dose was large, then the dose was reduced, now I haven’t been taking it for half a year.

I am currently taking Beclomethasone after suffering from pneumonia and exacerbation of bronchial asthma. I felt relief, and it helped quite a bit with complex therapy. So it's a good remedy.

I took Beclomethasone Aeronative, a good inhaler.

Nina V.: The article is useful, you can take note and apply it to yourself

Andrey: Not a word is said about choosing the size of stockings according to a person’s parameters: height, leg size, etc.

Olga: For coxarthrosis of the 2nd degree, I have been injecting for 4 years at the rate (after 6 months), there is no improvement.

Victoria: I don’t put my daughter in a car without taking a Dramamine tablet. We already had it.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/beklometazon

The drug "Beclomethasone": instructions for use, indications, analogues, reviews

Aerosol "Beclomethasone" is a hormonal glucocorticosteroid drug, which is intended for inhalation use to affect the mucous membrane of the respiratory canals. This medicine serves as one of the basic course of treatment for bronchial asthma.

Instructions for Beclomethasone are presented below.

Composition and release form of the medicinal product

The active component of this medication is beclomethasone dipropionate. The drug is released in the form of a metered spray. The medicine is produced in different volumes of nine, ten and twenty-three milliliters. The drug substance is contained in polyethylene bottles with a dispenser; in addition, the kit includes a spray nozzle. The nozzle and bottle are enclosed in a cardboard package.

Pharmacological action of the drug

According to the instructions, Beclomethasone has anti-inflammatory, anti-allergic, decongestant, anti-asthmatic and anti-exudative effects. Pharmacists note the pronounced glucocorticoid activity of the drug, as well as its weak mineralocorticoid effect.

What is the main effect of Beclomethasone?

The drug is able to increase the production of lipomodulin and reduce the release of arachidonic acid, reducing the synthesis of prostaglandins. Due to the reduction in the production of inflammatory exudate, along with lymphokines, the migration of macrophages is inhibited, which is accompanied by a slowdown in the processes of infiltration and granulation, among other things. Due to the influence of the presented drug, the basement membranes of the epithelium become thicker. In addition, the process of mucus secretion slows down due to goblet cells, and the number of fatty elements in the bronchial mucosa decreases. Also, the active component of the drug is able to relax the smooth muscles of the bronchi, promoting the active and rapid restoration of its sensitivity. This is confirmed by the instructions for use.

Beclomethasone restores the body's response to bronchodilators and, as a result, reduces the frequency of their use. This medication helps improve the functionality of external respiration. When the drug is used in therapeutic doses, adverse reactions characteristic of systemic hematopoietic stem cells are not observed. When using the product intranasally, hyperemia and swelling of the nasal mucosa are eliminated.

Beclomethasone analogues are of interest to many.

Pharmacokinetics and pharmacodynamics of the drug

When used intranasally, the active substance is absorbed through the nasal mucosa; in addition, a low level of absorption from the digestive system is noted.

Absorption, as a rule, occurs regardless of the type of administration. The substance is usually eighty-seven percent bound to plasma proteins. The main part is excreted from the body through the intestines, and about fifteen percent exits through the kidneys.

The therapeutic effect is observed within four to five days after the start of treatment, its peak can be observed within several weeks.

After administration of Beclomethasone aerosol by inhalation, some of the dose may be absorbed in the lungs. The bulk of the substance entering the digestive organs is inactivated during its first passage through the liver.

Indications for use of the medication

As the instructions for Beclomethasone indicate, the use of the presented drug by inhalation is prescribed for bronchial asthma as a basic treatment. In addition, the drug is used in situations of insufficient effectiveness of ketotifen, cromoglycic acid and bronchodilators in order to be able to reduce the dosage.

Intranasal use is advisable against the background of allergic rhinitis, both seasonal and permanent manifestations. Among other things, the prescription of Beclomethasone (in Latin - Beclometasonum) is practiced as part of the treatment of recurrent nasal polyposis and vasomotor rhinitis.

Local and external use of the product is practiced in combination with antimicrobial drugs against the background of infectious and inflammatory diseases of the ears and skin.

What else does the instructions for use for Beclomethasone say?

Contraindications to the use of the drug

The drug should not be used in cases of high sensitivity and under the age of six years. Inhalation use, in turn, is not practiced in the following situations:
  • Presence of acute bronchospasms.
  • As part of status asthmaticus, the drug is not used as a first-line medication.
  • Bronchitis of non-asthmatic origin.

Intranasal use should not be carried out with the following contraindications:

The indications for Beclomethasone must be strictly followed. It is also important to take into account that there are restrictions for intranasal use. These, as a rule, are recent surgical interventions in the nasal cavity along with ulcerations of the septum, recent injuries, glaucoma, amebiasis, hypothyroidism and severe liver failure. It is also recommended to use this drug with extreme caution if you have recently experienced a myocardial infarction. This points to the "Beclomethasone" instructions.

Side effects of the drug

When performing inhalations, the following adverse reactions are possible:

  • The appearance of a sore throat and hoarseness.
  • The occurrence of cough along with sneezing.
  • The presence of eosinophilic pneumonia and paradoxical bronchospasms.
  • Allergic reactions.

Treatment of candidiasis of the oral cavity, as well as the upper respiratory canals, occurs with the use of antifungal therapy, so taking Beclomethasone should not be stopped. It is important to keep in mind that systemic adverse reactions may occur when using the drug in excess doses of more than one and a half milligrams per day. The trade name "Beclomethasone" interests many. There are quite a large number of them - these are “Nasobek”, “Beclazon”, “Aldecin”, “Beconase”, “Beclamethasone DS” and so on.

When administered intranasally, the following side effects are likely:

  • The appearance of irritation and dryness of the nasal mucosa.
  • Pain in the throat and nasal cavity.
  • Nosebleeds.
  • The presence of nasopharyngeal infections that are caused by fungal flora.
  • The process of perforation of the nasal septum.
  • Rhinorrhea along with ulceration of the nasal mucosa.

If the drug is used for a long time in large doses, exceeding one and a half thousand micrograms per day, systemic adverse reactions may occur.

Systemic effects are likely to include dizziness and eye pain, along with drowsiness, increased intraocular pressure, visual disturbances, conjunctival hyperemia, changes in taste, allergic manifestations and myalgia. Long-term use of Beclomethasone may cause growth retardation in children.

Instructions for use of the drug

Instructions for use of the drug "Beclomethasone" provide for intranasal as well as inhalation use. In order to achieve pronounced results, it is recommended to use this product regularly. Dosing for inhalation use directly depends on the characteristics of the disease. Children should take a lower dose compared to adults.

When using a form of the drug containing fifty or one hundred micrograms of beclomethasone per dose, adults should receive this amount three to four times a day. If necessary, the dosage can be increased to six hundred to eight hundred micrograms. Children should receive fifty micrograms twice a day.

If a form of the drug is used containing two hundred and fifty micrograms of the active ingredient in one dose, then adult patients need to receive double the amount of this norm twice a day. If required, the dosage is increased to one and a half to two thousand micrograms per day. As part of intranasal use, fifty micrograms of Beclomethasone are injected into each nasal passage for inhalation two to four times a day.

Overdose

In case of overdose, as a rule, symptoms associated with pituitary-hypothalamic-adrenal insufficiency occur. In such a situation, the patient is transferred to treatment with systemic glucocorticoids for some time, and adrenocorticotropic hormones are also prescribed.

Interaction of the drug with other medications

With simultaneous use, the effect of beta-agonists is enhanced. Beta-adrenergic agonists, in turn, increase the anti-inflammatory effect of Beclomethasone, increasing the degree of penetration of its substance into the distal regions of the bronchi. Ephedrine can activate metabolic processes.

The effectiveness of Beclomethasone can be significantly reduced by inducers of elements of the microsomal oxidation process. When taken together with estrogens, methandienones, theophylline, beta2-adrenergic agonists and oral glucocorticoids, the effect of the active component of the drug is activated.

Terms of sale and storage

This medicine can be purchased only with a prescription. It should be stored in a dark place while maintaining a temperature of up to thirty degrees. The shelf life of Beclomethasone is three years, and after opening the drug can be stored for no more than six months.

Special instructions for use of the drug

This medicine should not be used to relieve acute asthmatic attacks. If acute attacks of bronchial asthma occur in response to the use of Beclomethasone, such treatment must be immediately discontinued.

In situations where patients have symptoms of pituitary-hypothalamic-adrenal insufficiency, patients can continue inhalations, but they will require strict monitoring of the presence of basal cortisol in plasma. In the same way, it is necessary to monitor these indicators if significant doses of beclomethasone are used for therapy.

Against the background of broncho-obstructive syndrome in moderate or severe form, it is necessary to use bronchodilators approximately twenty minutes before inhalation. Under no circumstances should the drug come into contact with the eyes.

When treating allergic rhinitis with severe symptoms, the effectiveness of the drug increases if it is used simultaneously with vasoconstrictors. In order to reduce the risk of pharyngeal candidiasis, inhalations should be carried out before meals, and also rinse your mouth after each procedure.

People with steroid-dependent asthma need to take higher doses of this medication. Patients with asthma should gradually switch from systemic glucocorticoids to inhaled Beclomethasone. Do not sharply reduce the dose.

Use of Beclomethasone during pregnancy

It is prohibited to use this drug to treat pregnant women in the first trimester, and in the second and third trimester it is allowed to use this medicine only when the expected benefit outweighs the probable level of risk. Children born to mothers who received Beclomethasone during pregnancy must be examined for the presence of functional adrenal insufficiency. As for breastfeeding during Beclomethasone therapy, it should definitely be stopped.

Analogues of "Beclomethasone"

Direct analogues that have beclomethasone dipropionate as an active ingredient are: “Beclat”, “Bekotide”, “Klenil” and “Beclomethasone-aeronativ”.

Medicines that have a similar effect and are related to the same pharmaceutical subgroup are the following medications: Benacort, Budenit, Budesonide, Budiair, Pulmicort, Flixotide, Novolizer and others.

Reviews about "Beclomethasone"

Reviews about this drug indicate that most often it helps to alleviate the condition of patients. There is information about the occurrence of some adverse reactions, but in general the comments from people who have been treated with the drug are positive.

Many people call it their salvation. Patients write that one dose of this remedy lasts them twelve hours. Thus, it is noted that the medicine perfectly helps to get rid of a painful cough and sore throat with frequent contact with allergens. In the comments, patients say that this medication always helps them effectively, and also that they often take it with them just in case.

In addition, it is reported that as part of annual treatment with Beclomethasone, this drug significantly improves the well-being of people suffering from bronchial asthma, as a result of which shortness of breath and cough disappear. Buyers cite the main disadvantage of this medicine as the price, which is four hundred rubles per bottle.

Source: http://www.syl.ru/article/355219/preparat-beklometazon-instruktsiya-po-primeneniyu-pokazaniya-analogi-otzyivyi

Beclomethasone: instructions for use, price and reviews

Beclomethasone is a glucocorticoid drug that affects the mucous membrane of the respiratory tract. The drug is used for the basic treatment of various forms of bronchial asthma, allergic rhinitis in children and adults.

According to experts, it is an effective anti-inflammatory and antiallergic agent for inhalation use. The results of using the drug become noticeable 5–7 days after the start of use.

Indications for use

Beclomethasone helps eliminate epithelial edema and hyperemia, reduces bronchial hyperactivity, improves external respiration and the general condition of patients, and has a bronchodilator effect.

The drug is prescribed for the treatment of diseases:

  • Bronchial asthma;
  • Prevention of allergic rhinitis during hay fever;
  • Inflammatory and infectious diseases of the ear;

Beclomezaton: instructions for use

For inhalation use: adults are prescribed 500 mcg twice a day or 250 mcg four times a day; children under 6 years old - pump up to four times.

For intranasal use in adult patients and children over 12 years of age, beclomesatone is prescribed 100 mcg 3-4 times a day in each nasal passage; children under 12 years of age - 50 mcg in each nasal passage (no more than 500 mcg per day) with the same frequency of use.

The exact regimen of use of the drug and the duration of the course of treatment are determined by the attending physician on an individual basis. According to doctors, the use of the drug is effective for treating patients of any age.

Contraindications

The use of beclomethasone is not recommended in the following cases:

  • severe attacks of bronchial asthma;
  • for pulmonary tuberculosis;
  • candidomycosis of the upper respiratory tract;
  • in the first trimester of pregnancy;
  • individual intolerance to the components included in the drug;
  • bronchitis of non-asthmatic origin and bronchospasms;
  • periodic nosebleeds;
  • children under 6 years old.

The drug is used with extreme caution in the presence of glaucoma, frequent viral and bacterial infections, osteoporosis, liver diseases, and hypothyroidism.

Beclomethasone: side effects

Violation of the dosage and non-compliance with beclomethasone instructions for use of the drug can cause a number of undesirable consequences.

Candidiasis of the oral cavity and pharynx. To reduce the side effect, it is necessary to rinse your mouth after using the drug and treat the spacer;

Skin rash, redness of the skin, hives and itching may occur. Some experience swelling of the mucous membrane of the lips of the eyes, angioedema, and an anaphylactic reaction to the drug.

On the part of the endocrine system, suppression of the function of the adrenal cortex, growth retardation in children, and the formation of glaucoma and cataracts can be observed.

In the case of systematic use of the drug, patients, according to doctors, complain of hoarseness and the appearance of bronchospasms. In this case, the instructions for use of the drug recommend immediately stopping the medication until further examination of the patient and the appointment of another drug.

With prolonged intranasal use of the drug, perforation of the nasal septum may occur. The use of beclomethasone can lead to thinning of the subcutaneous adipose tissue and the formation of bruises on the skin.

Beclomethasone: release form

The drug beclomethasone aerosol is dispensed in a pharmacy with a doctor's prescription. The drug is an aerosol packaged in sealed aluminum containers with a metering valve with a spray and a protective cap, 200 doses each. The cylinder dosage is 50 mcg/dose, 100 mcg/dose, or 250 mcg/dose.

special instructions

When prescribing a drug, it is necessary to familiarize the patient with the instructions for its use, which will ensure complete penetration of the drug into the upper respiratory tract and areas of the lungs.

The development of candidiasis in some patients may be associated with a previous fungal infection and a high level of antibodies in the blood against the fungal infection. In this case, patients are prescribed topical drugs against fungal infections, which are used in conjunction with beclomesatone.

Instructions for using the inhaler

To effectively use the drug, special dispensers are used - spacers, which distribute the drug into the lung tissue and prevent the occurrence of side effects.

When using the drug, you must follow the safety rules:

  • protect your eyes to avoid contact with the medicine;
  • The used cylinder must not be punctured, heated or disassembled. When using the drug at low temperatures, it is recommended to first heat the balloon in your hands, after removing the nozzle from it.
  • Before the first use, you must check the operation of the can. To do this, you need to remove the protective cap, turn the bottle upside down, shake it several times and make several presses until a stream of medicine appears.
  • If the drug beclomesatone is used regularly, the following procedure should be followed:
  • remove the protective cap from the nozzle. Make sure that it is free of dust and dirt;
  • hold the bottle vertically upside down. Place your index finger on the bottom of the container, and your thumb on the inhaler nozzle. Shake the can several times;
  • Exhale deeply and pinch the nozzle tube with your lips;
  • while taking a slow, deep breath, press the nozzle and release a dose of medication while continuing to inhale slowly;
  • hold your breath for a few seconds and exhale slowly;
  • if more than one dose of the drug is needed, repeat the procedure after one minute.

The inhaler nozzle requires periodic cleaning. Once a week it must be washed in warm water, after removing it from the can. Heating devices should not be used for drying.

Interaction with other drugs

When beclomesatone aerosol is used together with other glucocorticoid drugs, it is possible to suppress the function of the adrenal cortex.

Beclomethasone analogues

Direct analogues of the drug containing beclomethasone as an active substance are Beclat, Beklospira, Klenil, Eco Easy Breathing, Beclomesaton-aeronativ.

Topical glucocorticoid drugs have a similar therapeutic effect: Asmanex Twistheiler, Benacort, Budecort, Budenit Steri-Neb, Pulmicort, Tafen Novolizer, Flixotide, Alvesco.

According to reviews from doctors and patients, beclomethasone analogues are not inferior in providing therapeutic effects and are affordable.

Beclomesaton price

You can purchase the drug beclomethasone at a pharmacy with a prescription from your doctor. The price for beclomethasone nasal aerosol ranges from 130 to 300 rubles, depending on the number of doses.

The price of an inhalation aerosol is from 250 rubles.

Reviews

To treat bronchospasm and shortness of breath, the doctor prescribed beclomethasone. After six months of use, the dose was reduced. Shortness of breath appears very rarely, but I continue to take the medicine. The drug is distinguished by a convenient release form and an affordable price.

Beclomethasone aeronative was used for a year to relieve attacks of bronchial asthma. The medicine was received at the clinic using a preferential prescription. Currently there are no problems with asthma.

About a year ago I started using beclomethasone for asthma attacks in cold air. After 4 months the dose was reduced. Currently I am no longer taking the drug.

I was prescribed beclomethasone after pneumonia and exacerbation of bronchial asthma. The drug helped with complex treatment. A good and effective product.

Source: http://lekarstva.guru/b/beklometazon-instruktsiya-po-primeneniyu-tsena-i-otzyvy.html

Beclomethasone: instructions for use

Compound

Beclomethasone 50 µg/dose: anhydrous ethanol, 1,1,1,2-tetrafluorodichloroethane

Beclomethasone 100 µg/dose: anhydrous ethanol, propylene glycol, 1,1,1,2-tetrafluorodichloroethane.

Beclomethasone 250 µg/dose: anhydrous ethanol, isopropyl alcohol, 1,1,1,2-tetrafluorodichloroethane

Description

pharmachologic effect

Inhibits the release of inflammatory mediators, increases the production of lipomodulin - an inhibitor of phospholipase A, reduces the release of arachidonic acid, and inhibits the synthesis of prostaglandins. Prevents the marginal accumulation of neutrophils, reducing the formation of inflammatory exudate and the production of lymphokines, inhibits the migration of macrophages, which leads to a slowdown in the processes of infiltration and granulation. Increases the number of active β-adrenergic receptors, restores the patient's response to bronchodilators, allowing them to be reduced in frequency. Under the influence of beclomethasone, the number of mast cells in the bronchial mucosa decreases, the swelling of the epithelium and the secretion of mucus by the bronchial glands decreases. Causes relaxation of bronchial smooth muscles, reduces their hyperreactivity and improves external respiration function. Does not have mineralocorticoid activity. In therapeutic doses it does not cause side effects characteristic of systemic glucocorticosteroids.

Indications for use

Contraindications

I trimester of pregnancy, children up to 4 years of age.

Pregnancy and lactation

If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.

Directions for use and doses

The drug Beclomethasone aerosol for inhalation is used only by inhalation. Patients should be aware that Beclomethasone inhalation aerosol is used to prevent the disease and should therefore be taken regularly, even when there are no asthma attacks. The dose of the drug is adjusted depending on the individual reaction. If improvement after the use of short-acting bronchodilators becomes less effective or more inhalations are required than usual, control treatment under the supervision of a specialist is necessary. For patients who find it difficult to synchronize breathing with the use of an inhaler, it is recommended to additionally use a spacer - a device to facilitate inhalation of inhaled drugs. For children, the use of a special pediatric spacer may also be recommended.

The initial dose of inhaled beclomethasone dipropionate should be adjusted based on the severity of the disease. The dose may be adjusted until control is achieved and then titrated to the lowest dose that maintains effective asthma control.

Adults (including older people):

Beclomethasone 50 mcg/dose:

The usual starting dose is 200 mcg 2 times / day. In severe cases, it can be increased by 1 mg/day (in this case, it is recommended to use a form of the drug with a high content of the active substance). The dose of the drug can then be adjusted to achieve control of asthma symptoms or reduced to the minimally effective dose, depending on the individual patient's response. The total daily dose should be administered two to four times daily.

Beclomethasone 250 mcg/dose:

The usual dose is 1000 mcg/day, which can be increased to 2000 mcg. It can be reduced if the patient's asthma has stabilized. The total daily dose should be administered two to four times daily. The Spacer device should always be used when administered to adults and adolescents 16 years of age or older at a total daily dose of 1000 mcg or more.

Beclomethasone 50 mcg/dose:

The usual starting dose is 100 mcg 2 times a day. Depending on the severity of bronchial asthma, the daily dose can be increased to 400 mcg, which is administered in 2-4 doses.

Beclomethasone 250 mcg/dose:

Beclomethasone 250 mcg/dose is not recommended for children.

In patients with hepatic or renal insufficiency: No dose adjustment is necessary in patients with hepatic or renal insufficiency.

The sprayed aerosol is inhaled through the mouth into the lungs. Proper management is essential for successful therapy. The patient should be instructed on how to use beclomethasone correctly and is advised to read and follow the instructions printed in the package insert.

Instructions for use (rules for using the inhaler)

As with other inhaled medications, the therapeutic effect may decrease as the balloon cools. Cylinders must not be broken, punctured or burned, even if empty. If the inhaler is new or has not been used for three days or more, remove the mouthpiece cap by pressing lightly on the sides, shake the inhaler well and spray one spray into the air to ensure adequate operation.

1. Remove the mouthpiece cap by lightly pressing on the sides.

2. Make sure that there are no foreign objects inside and outside the inhaler, including the mouthpiece.

3. Shake the inhaler thoroughly to ensure that any foreign matter is removed from the inhaler and to ensure that the contents of the inhaler are evenly mixed.

4. Hold the inhaler vertically between your thumb and all other fingers, with your thumb on the base of the inhaler, below the mouthpiece.

5. Exhale as deeply as possible, then place the mouthpiece in your mouth between your teeth and cover it with your lips without biting.

6. Starting to inhale through your mouth, press the top of the inhaler to spray the drug, while continuing to inhale slowly and deeply (this releases one dose of the aerosol).

7. Hold your breath, remove the inhaler from your mouth and remove your finger from the top of the inhaler. Continue to hold your breath as long as possible.

8. If further sprays are necessary, wait approximately 30 seconds, holding the inhaler vertically. After this, follow steps 3-7.

9. Place the mouthpiece cap into place by pressing and clicking in the desired direction.

Important: follow steps 5, 6 and 7 slowly. It is important to start inhaling as slowly as possible before spraying. The first few times you should practice in front of a mirror. If a cloud appears at the top of the inhaler or on the sides of your mouth, you must start again from step 2.

Young children may need assistance, and it may be necessary for adults to administer the inhalations. The child should be asked to exhale and spray immediately after the child begins to inhale. It is recommended to master the technique together. Older children or frail adults can hold the inhaler with both hands. Place both index fingers on the top of the inhaler and both thumbs on the base below the mouthpiece.

The inhaler should be cleaned at least once a week:

1. Remove the metal canister from the plastic case of the inhaler and remove the mouthpiece cap.

2. Wipe the plastic case and mouthpiece with a damp cloth.

H. Allow to dry in a warm place. Avoid excessive heat.

4. Place the metal balloon and mouthpiece cap in place. The patient should be counseled about the importance of rinsing the mouth and throat with water or brushing teeth immediately after using the inhaler. The patient should be informed of the importance of cleaning the inhaler at least once a week to prevent blockage and of carefully following the instructions for cleaning the inhaler printed in the package insert. The inhaler must not be washed or placed in water.

Side effect

The following side effects are systematized by organs and systems depending on the frequency of occurrence: very often (1/10), often (1/100 and <1/10), infrequently (1/1000 and <1/100), rarely (1/100) 10000 and <1/1000) and very rarely (<1/10000), including isolated reports. Data on very common, common and uncommon side effects are mainly based on clinical studies. Data on side effects that occur rarely and very rarely are obtained mainly spontaneously.

Infections and infestations: very often - candidiasis of the oral cavity and pharynx. Some patients may develop candidiasis of the oral cavity and pharynx, the frequency of which increases with high doses (more than 400 mcg of beclomethasone dipropionate per day). This complication most often occurs in patients with high levels of Candida precipitins in the blood, which indicates a previous infection. In this case, it is useful to rinse the mouth after inhalation. If necessary, an antifungal drug is prescribed throughout the entire treatment period, while continuing the use of beclomethasone.

Immune system: hypersensitivity reactions have been reported with the following manifestations: infrequently - skin rash, urticaria, itching, erythema; very rarely - angioedema of the eyes, face, lips and oropharynx, respiratory symptoms (shortness of breath and / or bronchospasm) and anaphylactoid / anaphylactic reactions.

Endocrine system: possible systemic effects, including: very rarely - Cushing's syndrome, Cushingoid signs, adrenal suppression, growth retardation in children and adolescents, decreased bone mineralization, cataracts and glaucoma.

Mental disorders: very rarely - anxiety, sleep disturbances, behavior changes, including hyperactivity and excitability (mainly in children).

Respiratory system and chest: often - hoarseness, sore throat. In some patients, inhaled beclomethasone dipropionate may cause hoarseness or throat irritation; in this case, gargling with water immediately after inhalation is helpful; very rarely - paradoxical bronchospasm.

As with treatment with other inhaled drugs, the development of paradoxical bronchospasm with rapidly increasing shortness of breath after inhalation is possible. In this case, fast-acting inhaled bronchodilators are immediately used, beclomethasone inhalation is immediately stopped, the patient is examined and, if necessary, alternative therapy is prescribed.

Overdose

Acute overdose can lead to a temporary decrease in adrenal function, which does not require emergency treatment, since adrenal function is restored within a few days, as confirmed by plasma cortisol levels.

In case of chronic overdose, persistent suppression of the function of the adrenal cortex may be observed.

In such cases, it is recommended to monitor the reserve function of the adrenal cortex. In case of overdose, treatment with beclomethasone can be continued in doses sufficient to maintain the therapeutic effect.

Interaction with other drugs

With simultaneous use of beclomethasone with other corticosteroids for systemic or intranasal use, increased suppression of adrenal cortex function is possible. Previous inhaled use of beta-agonists may increase the clinical effectiveness of beclomethasone. Phenobarbital, phenytoin, rifampicin and other inducers of microsomal oxidation reduce effectiveness. Due to the small amount of ethanol contained, an interaction may occur in hypersensitive patients taking disulfiram or metronidazole.

Features of application

Beclomethasone does not provide relief of acute asthma symptoms that require short-acting inhaled bronchodilators. Patients must have means to stop an attack. Severe asthma requires regular medical evaluation, including pulmonary function testing, as there is a risk of severe attacks and even death. Patients should be instructed to seek medical attention if treatment with short-acting bronchodilators becomes less effective and more inhalations are required than usual, as this may indicate worsening asthma control. If this occurs, patients should be evaluated and the need for increased anti-inflammatory therapy (eg, higher doses of inhaled corticosteroids or a course of oral corticosteroids) should be considered. Treatment of exacerbations of severe asthma should be carried out as usual, that is, by increasing the dose of inhaled beclomethasone dipropionate, prescribing systemic steroids if necessary and/or an appropriate antibiotic if there is infection, along with β-agonist therapy. Treatment with beclomethasone should not be stopped abruptly. Systemic effects of inhaled corticosteroids may occur, especially when given in high doses for a long time. These effects are much less likely than with oral corticosteroids. Possible systemic effects include: adrenal suppression, growth retardation in children and adolescents, decreased bone mineral density, cataracts and glaucoma, a number of psychological or behavioral effects including psychomotor hyperactivity, sleep disturbances, anxiety, depression or aggression (especially in children). It is important that inhaled corticosteroid doses be titrated to the lowest dose that maintains effective asthma control. It is recommended to monitor the growth of children receiving long-term treatment with inhaled corticosteroids. If growth slows, therapy should be reconsidered with a view to reducing the dose of inhaled corticosteroids; if possible, the lowest dose that maintains effective asthma control should be given.

Long-term treatment with high doses of inhaled corticosteroids can lead to clinically significant adrenal suppression. Additional use of systemic corticosteroids should be considered during periods of stress or elective surgery.

Patients treated with systemic steroids for a long period of time or in large doses who are prescribed beclomethasone require special care, since recovery from possible adrenal suppression may take considerable time. A reduction in the dose of systemic steroids can be started approximately one week after starting treatment with beclomethasone. The size of the dose reduction should be consistent with the maintenance dose of systemic steroids. For patients receiving maintenance doses of prednisolone 10 mg per day (or equivalent), reduce the dose to no more than 1 mg per week. For higher doses, longer dose reduction intervals may be appropriate. Adrenal cortex function should be monitored regularly while the dose of systemic steroids is gradually reduced.

Some patients do poorly during systemic steroid withdrawal, despite maintaining or even improving respiratory function. Persistent use of inhaled beclomethasone dipropionate should be encouraged and systemic steroid withdrawal should be continued if there is objective evidence of adrenal insufficiency. Patients weaned from oral steroids whose adrenal function is impaired should have steroid warning cards, information from which may be required if additional systemic steroids are required during periods of stress, such as worsening asthma attacks, thoracic infection, serious intercurrent illness, surgery, trauma etc.

Replacing systemic steroid therapy with inhaled therapy sometimes clears up allergies, such as allergic rhinitis or eczema, previously controlled with a systemic drug. These allergies require symptomatic treatment with antihistamines and/or topical agents, including topical steroids.

As with all inhaled corticosteroids, special attention is required in patients with active or quiescent pulmonary tuberculosis.

Patients should be informed that this product contains small amounts of ethanol (approximately 9 mg per dose). At normal doses, the amount of ethanol is small and does not pose a risk to patients.

Release form

Storage conditions

Keep out of the reach of children

Best before date

Conditions for dispensing from pharmacies

Beclomethasone analogues, synonyms and group drugs

You should consult your doctor and read the instructions before use.

Source: http://apteka.103.by/beklometazon-instruktsiya/