Staphylococcal bacteriophage instructions for children

Posted on by admin

Staphylococcal Bacteriophage: instructions for use, reviews from people

Staphylococcal bacteriophage is a bacterial virus that can destroy only strains of staphylococci.

It is believed that in one second a bacteriophage is capable of infecting about 10²³ bacterial cells.

Table of contents:

They work especially well against bacteria that have a dense polysaccharide cell membrane that is difficult for antibiotics to penetrate. In such cases, phage therapy has an advantage over antibiotic treatment.

On this page you will find all the information about Staphylococcal Bacteriophage: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Staphylococcal Bacteriophage. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Conditions for dispensing from pharmacies

Available without a prescription.

How much does staphylococcal bacteriophage cost? The average price in pharmacies is 750 rubles.

Release form and composition

This drug is available in the following forms and compositions:

  1. In liquid form\bottles of 100,50,20 milliliters and aerosols of 25 ml.
  2. In the form of ointments, 10 and 20 grams.
  3. In candles (10 pieces in one package).

This drug is a product in liquid form of a bacterial culture and is a combination of bacterial cell particles and a special nutrient medium that contains bacteriophage particles. This product is active against the following staphylococci (aureus, epidermal, saprophytic).

Pharmacological effect

Staphylococcal bacteriophage is a drug that in a certain way affects staphylococci of the most common strains. When combined with a bacterium, it dissolves it and removes the remaining decay from the body.

It is an antibacterial drug with immunobiological effects and is prescribed for the treatment of infectious diseases caused by staphylococci. A wide spectrum of action on pathogenic strains gives effective results in complex treatment. Does not affect beneficial bacteria found in the human body.

Indications for use

Staphylococcal bacteriophage is used to treat:

  • generalized sepsis and peritonitis;
  • other diseases resulting from the spread of staphylococcus;
  • surgical infectious diseases (wounds with pus discharge, burns with associated infection, hidradenitis, pandactylitis, mastitis, parapraktitis and others);
  • pathology of the urogenital system (almost all diseases of the urinary and reproductive systems);
  • gastroenteral pathology (inflammation of the mucous membrane, dysbacteriosis and others);
  • diseases of the upper respiratory tract and bronchopulmonary system; these include various types of sinusitis, rhinitis, acute and chronic tonsillitis, otitis media, pharyngolaryngitis, tracheobronchitis, pneumonia and pleurisy);
  • as a preventive measure for fresh infected wounds (after operations in the abdominal and thoracic cavities);
  • as a prevention of the development of nosocomial infections.

It is very important for effective phage therapy to first determine the phage sensitivity of the pathogen; this is the sensitivity to staphylococcal bacteriophage of strains selected from the patient.

Advantages over antibiotics

The bacteriophage has an antibacterial effect. Antibiotic drugs also have it. Medicines differ from each other in several ways. Judging by the reviews, the bacteriophage has undeniable advantages that allow you to make a choice in favor of it rather than antibiotics.

These advantages are the following:

  • can be prescribed for the purpose of prevention;
  • allowed for people of any age, even infants;
  • not prohibited for pregnant and lactating women;
  • have no contraindications;
  • effective against microorganisms that are insensitive to antibiotics;
  • can be used with all other medications, including antibiotics;
  • does not suppress human immunity;
  • does not lead to the development of phage-resistant cultures;
  • do not destroy beneficial bacterial microflora;
  • do not lead to addiction;
  • has an immunomodulatory effect.

Contraindications

According to the instructions, Staphylococcal Bacteriophage is contraindicated in cases of hypersensitivity or intolerance to the components of the drug.

Use during pregnancy and lactation

The absence of serious contraindications and side effects made it possible to use Antistaphylococcal Bacteriophage in the treatment of infections in pregnant women. An important condition is that therapy should be prescribed only by a doctor and carried out under his supervision. In addition, this type of bacteriophage is also prescribed only if the expectant mother has an infection caused by staphylococci.

Instructions for use

The instructions for use indicate that Staphylococcal Bacteriophage is intended for local, rectal and oral use. Shake the bottle before use; if there is visible sediment or changes in transparency, the solution should not be used. To achieve the maximum therapeutic effect, treatment should begin as soon as possible after the onset of symptoms of the disease. The duration of therapy, the regimen of use of the drug and the dose are determined by the doctor.

Recommended single doses for patients of various age groups:

  • For adults and children over 8 years of age, it is recommended to administer 30 ml of Staphylococcal Bacteriophage solution orally and 50 ml of the drug for rectal use;
  • Children 3-8 years old are usually prescribed 40 ml of bacteriophage rectally, and 20 ml of the drug orally;
  • Children 1-3 years old are usually prescribed 30 ml of bacteriophage rectally, and 15 ml of the drug orally;
  • Children 6-12 months old are usually prescribed 20 ml of bacteriophage rectally, and 10 ml of the drug orally;
  • Children under 6 months of age are usually prescribed 10 ml of bacteriophage rectally, and 5 ml of the drug orally. The first doses of the drug should be administered in the form of high enemas; if there is no development of regurgitation, digestive disorders and other undesirable effects, the bacteriophage can be administered orally or orally and rectally.

The average duration of therapy ranges from 7 to 20 days. For recurrent forms of the disease, several courses of the drug Staphylococcal Bacteriophage can be prescribed per year.

The drug is used locally depending on the location of the infection:

  1. In surgical practice, the solution is used in the form of washing, irrigation, tamponing, as well as for introduction into drained or limited cavities;
  2. In gynecological practice, the drug is used in the form of irrigations, applications and tampons moistened with a solution;
  3. In otolaryngological practice, the solution is used for washing, irrigation, wetting of sterile turundas, and also as nasal and ear drops;
  4. Introduction into the articular, pleural and other limited cavities, including the drained cavity of the bladder and renal pelvis, through capillary drainage, nephrostomy or cystostomy;
  5. For intestinal diseases, rectal administration of the bacteriophage is prescribed (in combination with oral administration).

It should be taken into account that if, before topical use of the drug Staphylococcal Bacteriophage, treatment was carried out with chemical antiseptics, then before using the bacteriophage, the area of ​​the skin should be washed with an isotonic sodium chloride solution.

Side effects

During the study of the drug, no side effects from its use were identified. Judging by the reviews, they are observed only with intradermal administration. Inflammation and hyperemia may occur here, but they are short-lived.

Overdose

Symptoms in case of an overdose of Bacteriophage have also not been studied, therefore they are also not described in the instructions for use of the drug.

special instructions

When opening the bottle, storing and sampling the product, the following rules should be observed:

  1. Hands must be washed thoroughly;
  2. Before removing, the cap must be treated with an alcohol solution;
  3. The cap should be removed without removing the stopper;
  4. The drug should be removed from an opened bottle only by piercing the stopper with a sterile syringe;
  5. If, during opening, the cork was accidentally uncorked along with the cap, then it should not be placed with the inner surface on the table, and the bottle should not be left open (after taking the product, it must be closed with the cork);
  6. It is recommended to store the opened bottle in the refrigerator.

Subject to compliance with the specified rules and in the absence of turbidity, the product from the opened bottle can be used throughout the entire shelf life.

Drug interactions

The drug can be used in combination with other drugs, including antibiotics.

Reviews

Reviews about Staphylococcal Bacteriophage are mostly positive. Patients confirm the high effectiveness of the drug in the fight against diseases caused by staphylococci, and consider it a worthy and safer alternative to antibiotics. However, there are also individual reviews that indicate that the bacteriophage was ineffective and even caused side effects (diarrhea, increased body temperature), although the instructions indicate that the drug was very well tolerated and there were no unwanted reactions.

The disadvantages of almost all patients include the high cost of Staphylococcal Bacteriophage and its unpleasant taste, as well as the inconvenience of storage (in the refrigerator) and use (the need to draw the solution with a sterile syringe to maintain asepsis).

Analogs

The staphylococcal bacteriophage has a number of drugs that are similar to it in the principle of action, i.e. also having an antibacterial effect against certain pathogenic microorganisms. Such means include:

Before using analogues, consult your doctor.

Storage conditions and shelf life

Storage at a temperature of 2 to 8 °C, protected from light and out of reach of children. Transportation at temperatures from 2 to 8 °C, transportation at temperatures from 9 to 25 °C is allowed for no more than 1 month.

Shelf life: 2 years. A drug that has expired cannot be used.

Good to know:

We recommend reading:

Pimafukort

Pantsef

Palin

Oftaquix

Oflomelid

Ofloxacin

Olethetrin

Normax drops

One comment

My child has chronic tonsillitis. Exacerbations were very frequent. Last year we were sick 9 or 8 times. Every now and then we missed school and SAMBO. Often treatment was not possible without antibiotics. Preventative rinses did not give the desired result. At first there was bad breath, and after a few days the throat started to hurt.

I went to the pediatrician and asked for a referral to take a smear to check for various cogs in the throat. We took tests. It turned out to be nothing serious, only staphylococcus, which any person normally has. But apparently my child’s tonsils (due to their peculiarities) and immunity could not cope with so much staphylococcus. The doctor prescribed a course of inhalations with staphylococcal bacteriophage. We bought a compressor nebulizer, and my son once again complained about his throat.

I ran to the pharmacy. I didn’t find this bacteriophage in the first pharmacy. I had to look. The drug is quite expensive. I bought it. We started doing inhalations. By the way, the child did not feel any unpleasant taste or smell when inhaling it. Within a day of inhalation the result was noticeable. My son didn't get sick as usual. The process has slowed down. He suffered a mild exacerbation, without fever. The cough quickly became wet. We completed the course without any symptoms. And the course is 10 days, 3 times a day. By the way, the runny nose also went away faster than usual. I was very glad that there were no antibiotics or any other medications.

The first time we got over it so easily. More than six months have already passed. We have never been seriously ill. The smell from my mouth has disappeared. Once recently I had a runny nose, which did not go down to my throat, as it did before. We breathed mineral water and everything was ok! I am very pleased with the results from this drug. I think that I will do a course with bateriophage once a year for prevention. This is an excellent alternative to antibiotics.

Add a comment Cancel reply

Transcription of analyzes online

Doctors consultation

Fields of Medicine

Popular

This is interesting

Only a qualified doctor can treat diseases.

Source: http://simptomy-lechenie.net/stafilokokkovyj-bakteriofag/

Staphylococcal bacteriophage - a real alternative to antibiotics or a drug with questionable effectiveness?

Diseases of the ENT organs are distinguished by their wide prevalence among the population and the frequent formation of numerous and sometimes quite serious complications. The generally accepted approach to the treatment of such diseases is treatment with antibiotics, which is not without its drawbacks due to the development of bacterial resistance to agents with antimicrobial activity.

One of the most successful trends in the treatment of upper respiratory tract diseases of infectious origin is the use of bacteriophages. Information about bacterial viruses first appeared more than a hundred years ago, and the first data on effective treatment with their help were made at the beginning of the 20th century. However, the scope of use of phages is still quite limited. Recently, there has been interest in the possibilities that such therapy opens up. The drug Staphylococcal bacteriophage has become widespread in otorhinolaryngology.

>> The site presents an extensive selection of medications for the treatment of sinusitis and other nasal diseases. Enjoy it for your health! <

What is this medicine?

Bacteriophages are viruses that are destructive only against bacteria. The mechanism of their action is to penetrate the bacterial cell and interact with its genome, which leads to their reproduction and subsequent destruction of the pathogen. Most often, bacteriophages are specific and destroy only one specific type of pathogenic bacteria, but there are also polyvalent phages that can parasitize bacteria of different types.

Staphylococcal bacteriophage is a bacterial virus that can destroy only strains of staphylococci. It is believed that in one second a bacteriophage is capable of infecting about 10²³ bacterial cells. They work especially well against bacteria that have a dense polysaccharide cell membrane that is difficult for antibiotics to penetrate. In such cases, phage therapy has an advantage over antibiotic treatment.

Bacteriophages and antibiotics are not the same thing. These drugs are not interchangeable, and the decision to switch to phage therapy should only be made by a doctor. Despite the benefits of phages, in some cases it is not possible to achieve a cure without antibiotics. Before use, be sure to consult a doctor.

For any infection, can it be recommended to take staphylococcal bacteriophage?

The use of this medicine is justified only if the cause of the infection is bacteria of the genus Staphylococcus. The most common pathogen is Staphylococcus aureus. In the annotation for the drug, indications include diseases of various body systems, including enteral, surgical, and urogenital infections.

In ENT practice, it is used for the treatment and prevention of infections of the bronchi, trachea, nose, lungs, ear, throat (otitis, sinusitis, sinusitis, sinusitis, pharyngitis, tracheitis, bronchitis, pneumonia).

Detection of the sensitivity of pathogenic microorganisms to bacteriophage and its use in the early stages of disease development is the most important point in phage therapy.

Sometimes a medicine is prescribed without first determining sensitivity. Most often, in such cases, the doctor uses a combination of staphylococcal bacteriophage with an antibiotic, which enhances the effectiveness of treatment. It is prohibited to use phage monotherapy to treat an infection that occurs with signs of severe intoxication (fever, chills) without consulting a specialist.

How to use staphylococcal bacteriophage?

The drug is available in the form of a transparent solution with a yellowish tint. Before use, you need to pay attention to its color and the absence of sediment in the contents of the bottle.

The medicine is suitable for use both orally (orally) and topically (nasal mucosa, paranasal sinuses). In the treatment of infectious diseases of the nose and sinuses, the drug is prescribed in a dose of 2 to 10 ml 1-3 times a day. The solution can also be used to irrigate the nasal cavity, gargle and introduce moistened turundas into the nasal passages, which should be left for an hour.

When using, questions often arise about how to gargle correctly or how to drip staphylococcal bacteriophage into the nose, because these nuances are not well covered in the instructions. The solution should not be diluted with other liquids. To prevent the penetration of bacteria, it is better to remove the contents by piercing the stopper with a disposable sterile syringe. Then remove the needle from the syringe and immediately drop it into your nose or gargle, without first pouring the solution into a non-sterile container.

For preventive purposes, in case of unfavorable epidemiological conditions, weakening of the body, it is recommended to instill the bacteriophage into the nose monthly for one or two weeks, 2 times a day.

The effect of treatment with the drug should appear within the first two days. If the condition worsens, you must stop therapy yourself and immediately consult a doctor.

Due to the fact that the solution of staphylococcal bacteriophage contains a live culture of bacterial viruses, a number of rules should be followed when using it:

  • wash your hands well before use;
  • treat the bottle cap with a solution containing alcohol;
  • do not leave the bottle cap on non-sterile objects;
  • do not keep the bottle open;
  • Store opened packaging only at temperatures from 2 to 8°C.

If used correctly, the bacteriophage can be used for 2 years after opening. Medicines that have expired cannot be used.

How to properly treat sinusitis with Staphylococcal bacteriophage?

Recently, the prevalence of chronic sinusitis has increased. For many years, antibiotics were used to prevent the transition of an acute process to a chronic one, but today the problem of the development of bacterial resistance to them has become very urgent. The most serious threat with regard to the development of sinusitis resistant to standard therapy is Staphylococcus aureus, when carried by Staphylococcus bacteriophage can be very effective.

To achieve the best effect of sinusitis therapy, the following scheme is proposed:

  1. Insert a catheter into the maxillary sinus and rinse it with 0.9% saline solution.
  2. Introduce 5 ml of bacteriophage solution into the sinus cavity. The procedure should be repeated 2 times a day for 5 or 6 days. This stage must be carried out in a clinic where a specialist installs a catheter.
  3. This stage of therapy can be carried out at home. It consists of instilling Staphylococcal bacteriophage into the nose, 5 drops in each nostril. It is also necessary to inject and leave turunda moistened with the drug in each nostril for 1 hour three times a day.

In severe cases of sinusitis, the specialist prescribes the simultaneous use of bacteriophage and antibiotics, which significantly reduces the duration of antibiotic therapy and increases its effectiveness.

Staphylococcal bacteriophage is safe for newborns

The instructions for use indicate that Staphylococcal bacteriophage is allowed for infants from the first days of life. The drug is used in the following doses (calculated for a single dose):

  • 0 – 6 months – 5 milliliters;
  • 6 - 12 months - 10 milliliters.

For children from one to three years old, the dosage of Staphylococcal bacteriophage is 15 milliliters, from 3 to 8 years old - 15 - 20 ml, over 8 years old - ml. For rectal administration, the dosage should be approximately doubled. The frequency of use should be determined by the doctor depending on the severity of the disease and the goals of therapy.

Which form of Staphylococcal bacteriophage should I choose: liquid, ointment or tablet?

To date, only one Staphylococcal bacteriophage has been registered in the Russian Federation, which is available in glass bottles of 20 ml and 100 ml. Staphylococcal bacteriophage does not have the form of tablets, rectal suppositories or ointments, but is presented only as a solution, which, if desired, can be ingested or used rectally with enemas.

Advantages of Staphylococcal bacteriophage over antibiotics

Like antibiotics, the main effect of bacteriophages is to destroy bacteria, but unlike them, phages have a number of advantages.

The table shows the main differences between antibiotics and bacteriophages.

The use of Staphylococcal bacteriophage during pregnancy is not prohibited, but before use it is necessary to consult a doctor.

Are there any disadvantages?

Such obvious advantages of bacteriophages should put an end to antibiotic therapy. But it's not that simple. In our country, bacteriophage therapy is gradually becoming more widespread, but foreign specialists are skeptical about them and never use them as the only means of treatment. What is the reason for this contradiction?

This medicine is not always effective enough against serious infections, and besides, it is strictly specific. Due to the fact that it is not intended for intravenous and intramuscular use, it is not always possible to achieve the required bactericidal concentration. Therapy with such drugs is a good support for antibiotics, but not a replacement for them.

Why might analogues of Staphylococcal bacteriophage be better than the original?

In our country, Staphylococcal bacteriophage has been produced by the Federal State Unitary Enterprise NPO Microgen of the Russian Ministry of Health since the 40s of the 20th century. It is unique in its own way and specific for bacteria of the genus Staphylococcus. Its cost ranges from 750 to 850 rubles.

To date, polyvalent bacteriophages (Sextaphage) have been synthesized, which are capable of destroying not only staphylococci, but also other bacteria that are important in the development of diseases of the ENT organs. It can be used topically, in the form of irrigation, rinsing, for rinsing and injection into the paranasal sinuses. The dose is determined individually. The duration of therapy can range from 5 to 15 days. If necessary, repeated courses of therapy can be carried out. The average price in pharmacies is 650 rubles.

Another product with a similar effect is Otofag gel, produced by the MicroMir Scientific and Production Center since 2012. This is a new drug that contains a cocktail of phages that has a wide spectrum of activity against various bacteria. It is recommended to apply the gel locally in the form of applications on the mucous membrane of the nasal cavity and palatine tonsils 2-3 times a day until symptoms disappear. The gel is easy to use and is often recommended as a preventive measure. The disadvantage may be that it is not suitable for washing the paranasal sinuses, which is very useful in the treatment of sinusitis. On average, its price is 850 rubles.

Polyvalent bacteriophages are better because they can be used for combined infections. Using only a specific bacteriophage without determining the sensitivity of bacteria to it, there is a risk of conducting a course of useless therapy. Combination drugs have a much wider spectrum of action. Considering approximately the same cost, it is sometimes better to give preference to a polyvalent medicine that can destroy bacteria of different types and strains.

Evidence base for the effectiveness of Staphylococcal bacteriophage

Staphylococcal bacteriophage has undergone a number of clinical trials, during which it has proven its effectiveness against infection with various strains of staphylococci. In particular, after phage therapy, in the majority of people who had moderate growth of Staphylococcus aureus on the mucous membrane, Staphylococcus aureus was not detected within one month. This is a very good result, because it is almost impossible to eliminate Staphylococcus aureus from the body by using standard antibiotic therapy.

In the examined group, the carriage rate of Staphylococcus aureus after treatment with Staphylococcal bacteriophage decreased from 35% to 5%. During the treatment, the subjects noted positive results in the form of disappearance of rhinitis, sore throat and sinus congestion.

Share with others.

Good articles to follow:

Very good promotion from pharmaceutical companies that release these drugs. No bacteriophage will ever replace a broad-spectrum antibiotic. The only question is the rational use of drugs. I would look into the eyes of a specialist who would prescribe bacteriophage to a child with moderate acute bronchitis or pneumonia.

Exactly the same promotion as the antibiotics themselves.

Gentlemen, before you doubt, without trying the medicine, do not say loud words. Bacteriophages helped us a lot, despite the fact that we fell ill with purulent sore throat 3 times in a row, the first two times we took antibiotics, but the third time, although streptococcus was discovered, she said we’ll leave the therapy next time At the same time, the child’s sinusitis was not cured and the tonsils were enlarged to the 3rd degree. We drank bacteriophages and were very pleased, but the doctors still did not understand how we were cured.

Source: http://gaimoriti.ru/medicamenty/stafilokokkovyj-bakteriofag.html

Staphylococcal bacteriophage: instructions for use

Staphylococcal bacteriophage is an immunobiological drug that contains specific viruses that can infect bacterial cells that are sensitive to them. This drug is used only in the presence of an infectious process in the body caused by bacteria of the genus Staphylococcus (staphylococci).

Release form and composition

There are several dosage forms of staphylococcal bacteriophage. The solution is available in glass bottles of 20, 50 and 100 ml. It contains lyophilisate (cell components) of staphylococcus bacteria, live bacteriophages and a preservative (quinosol). The solution is a dark yellow transparent liquid without impurities or sediment.

pharmachologic effect

The staphylococcal bacteriophage solution contains specific viruses (bacteriophages) that are able to penetrate only susceptible bacterial cells. They are integrated into the genome of the bacterial cell, changing its metabolism, which leads to the synthesis of new bacteriophages. This in turn leads to damage (lysis) and death of the bacterium, the release of new bacteriophages that penetrate new sensitive bacterial cells. The staphylococcal bacteriophage does not infect human cells and other bacteria. The spectrum of effectiveness of this bacteriophage extends only to bacteria of the genus Staphylococcus (staphylococci), which cause pathological infectious processes of various localizations in the human body, in particular Staphylococcus aureus. The presence of lysate (components of staphylococcal bacterial cells) in the solution has a stimulating effect on the development of a specific antibacterial immune response.

After local injection of a solution of staphylococcal bacteriophage directly into the area of ​​the focus of the inflammatory infectious process, the bacteriophage practically does not penetrate into the systemic bloodstream; it directly affects staphylococcal bacterial cells that are localized in the focus of inflammation. The bacteriophage exists only if there is a staphylococcal infection. After the destruction of all bacterial cells, the number of bacteriophage particles decreases, and it is gradually eliminated (removed) from human tissues (for the most part, the remnants of these specific viral particles are absorbed and inactivated by cells of the immune system by macrophages).

Indications for use

A solution of staphylococcal bacteriophage is used to treat infectious processes in the body of various localizations caused by strains of bacteria of the genus Staphylococcus that are sensitive to it. Most often these bacteria cause the following diseases:

  • Purulent and infiltrative lesions of the skin and subcutaneous tissue - furuncle (purulent inflammation of one hair follicle), carbuncle (purulent process in which several hair follicles are involved), abscess (limited cavity filled with pus) of subcutaneous tissue and soft tissues, phlegmon (leakage of intercellular substance pus) and hidradenitis (bacterial infection of the sweat glands of the skin).
  • Infectious process in the upper respiratory tract - staphylococcal rhinitis (inflammation of the nasal mucosa), sinusitis (pathological process in the paranasal sinuses), otitis (inflammation of the ear), pharyngitis (inflammation of the pharynx), laryngitis (parasitism of staphylococci in the larynx), staphylococcal tonsillitis (purulent inflammation of the tonsils).
  • Infectious pathological process in the lower respiratory tract - tracheitis (localization of infection in the tracheal mucosa), bronchitis (pathological process in the bronchi) or pneumonia (pneumonia).
  • Urogenital infectious process - characterized by bacterial damage to the organs of the urinary system (kidneys, ureters, bladder and urethra) and genitals.
  • Staphylococcal damage to the digestive system - enterocolitis (inflammatory process of the small and large intestines), cholecystitis (pathological process in the gallbladder), inflammation of the tissue around the liver with the development of phlegmon or an abscess in it. Also, staphylococcal bacteriophage is used for intestinal dysbiosis (disturbance in the ratio of normal and conditionally pathogenic intestinal flora), in which the number of staphylococcal bacteria increases.
  • Purulent inflammatory processes in the body of a newborn of any localization, caused by parasitism of staphylococci.
  • A purulent-inflammatory process in the organs of the musculoskeletal system - infectious arthritis (joint damage), periarthritis (inflammation of periarticular tissues).
  • Prophylactic use to prevent purulent bacterial complications after various injuries associated with violation of the integrity of the skin or mucous membranes.
  • Generalized staphylococcal infection - sepsis (blood poisoning), in which bacteria spread throughout the body, their deposition in various tissues and organs with the development of secondary purulent processes.

An important condition for the use of staphylococcal bacteriophage is the presence of sensitivity of bacterial cells to it.

Contraindications for use

There are no absolute contraindications to the use of staphylococcal bacteriophage solution. Relative contraindications that require delaying the use of this immunobiological drug are determined by the doctor on an individual basis. Staphylococcal bacteriophage is not used if the causative agent of the infectious pathological process is not sensitive to it.

Directions for use and doses

The method of introducing or applying a solution of staphylococcal bacteriophage depends on the localization of the infectious process in the human body:

  • In case of pathology of the female genital organs, the solution is used in the form of irrigation or application to the mucous membrane.
  • If the skin, subcutaneous tissue, or soft tissues are affected, the solution is used in the form of washing the area of ​​inflammatory or purulent process. It is also possible to administer the solution intradermally or subcutaneously.
  • If the infectious process is localized in the digestive tract, the solution is administered into the rectum (rectal administration) or taken orally (through the mouth).
  • In case of disease of the upper or lower respiratory tract, irrigation of the mucous membranes or inhalation of the aerosol is carried out.
  • If the outer or middle ear or nasal mucosa is affected, the solution is instilled.

Recommended dosages of the drug depend on the age of the person, the method of administration and the severity of the pathological infectious process. When administered orally and rectally, the drug can be used by children from birth. The duration of treatment also depends on the severity of the staphylococcal infection, on average it is 7-20 days. In case of relapse (exacerbation), the drug can be reused up to several times during the year.

Side effects

After using a solution of staphylococcal bacteriophage, no cases of side effects were recorded.

special instructions

The use of a solution of staphylococcal bacteriophage should be carried out taking into account special instructions:

  • Before using a solution of staphylococcal bacteriophage, a mandatory bacteriological study is required to isolate staphylococcus and determine its sensitivity to the drug.
  • If solutions of local chemical antiseptics (chemical compounds that destroy various types of infection) are used the day before, the area treated with staphylococcal bacteriophage must be thoroughly rinsed with water, since antiseptic residues can lead to the death of bacteriophages.
  • The drug can be used during pregnancy or breastfeeding only after a doctor's prescription.
  • The solution does not affect the speed of psychomotor reactions and a person’s ability to concentrate.
  • Staphylococcal solution can be used in combination with antibiotics, since they do not have a negative effect on the viability of bacteriophages.
  • It is not allowed to use a cloudy solution if it contains sediment or flakes.

In the pharmacy chain, the drug is dispensed only with a doctor's prescription. Its use will be effective only after appropriate examination and doctor's prescription.

Overdose

Cases and symptoms of overdose of staphylococcal bacteriophage solution have not been described.

Analogs

There are dosage forms of staphylococcal bacteriophage in the form of aerosols, suppositories and tablets.

Terms and conditions of storage

An unopened solution of staphylococcal bacteriophage can be stored for 3 years from the date of its manufacture. Storage is possible only at temperatures from +2 to +8° C (temperatures up to +30° C are allowed during transportation of the drug, the duration should not exceed 30 days). The solution must be stored out of the reach of children.

Staphylococcal bacteriophage price

Staphylococcal bacteriophage, 100 ml - from 782 rub.

Source: http://bezboleznej.ru/bakteriofag-stafilokokkovyj

Staphylococcal bacteriophage: reviews. “Staphylococcal bacteriophage”: instructions for use, prices, analogues

The word is formed from two: bacterium (microbe, microorganism) and phagos (eating). So, bacteriophages are “microbe eaters”. Phagocytes are also present in the human body, forming part of the human immune system. The phage recognizes the desired bacterium and acts destructively on its wall, often settling inside it. In this article we will look at bacteriophages and the reviews available about them.

“Staphylococcal bacteriophage” – what is it?

This is a virus (eater) that specifically destroys pathogens of staphylococcal infections, such as:

  • staphylococcus auratilis (Staphylococcus aureus);
  • staphylococcus pneumoniae (causative agent of pneumonia);
  • staphylococcus epidermiale (causing infections of the skin and soft tissues), etc.

Instructions for use of “Staphylococcal bacteriophage”

“Staphylococcal Bacteriophage” collects only positive reviews. Let's take a closer look at the instructions for it.

Dosage form – solution for external and internal use.

Release form: 100, 50, and 20 ml in glass bottles, packed in a cardboard box of 1, 4, 10 pcs.

Ingredients: filtered lysate of pathogenic strains of staphylococcus, preservative quinone.

Description: colorless transparent or slightly colored liquid without sediment. It is an immunobiological drug.

This is confirmed by numerous reviews. “Staphylococcal bacteriophage” has the following effect on microbes and the human body. The phagocytes contained in the solution have the ability to differentiate bacteria and select microorganisms sensitive to the bacteriophage, causing their destruction, and multiply, generating new similar cells. Phagocytes do not have a destructive effect on the cells of the human body and do not cause them harm.

Areas of application

The instructions for use for the drug “Staphylococcal bacteriophage” indicate that it is used for diseases caused by staphylococcal infection:

  1. Ophthalmology: conjunctivitis, blepharitis.
  2. Otorhinolaryngology: otitis (inflammation of the outer, middle or inner ear), tonsillitis (inflammation of the tonsils), laryngitis (inflammation of the larynx), pharyngitis (inflammation of the throat), rhinitis (inflammation of the nasal mucosa).
  3. Pulmonology: diseases of the respiratory tract (tracheitis, bronchitis, pneumonia).
  4. Gynecology: vaginitis, inflammation of the cervix, uterine mucosa.
  5. Urology: pyelonephritis, cystitis, urethritis.
  6. Surgery: treatment of infected wounds, abscesses, inflammatory processes in the joints (arthritis, bursitis), stoma care, bacterial infections of the skin and soft tissues (furunculosis, carbunculosis, mastitis, hidradenitis, proctitis, paraproctitis).
  7. Burn surgery: treatment of poorly healing infected burns.
  8. Diseases of the gastrointestinal tract: gastritis, enterocolitis, colitis, cholecystitis, dysbacteriosis (prevention and treatment).

This drug is also used to treat inflammatory processes in the body of newborns, generalized staphylococcal infection (sepsis), to prevent nosocomial infections, to prevent acute respiratory and viral infections caused by staphylococcus (to increase local immunity).

It is important to remember that staphylococcal bacteriophage destroys only the causative agents of staphylococcal infections.

Directions for use and required dosage

The instructions for use for the drug “Staphylococcal bacteriophage” indicate that it is used depending on the location of the inflammatory process. Before use, you must ensure that there is no sediment or foreign particles in the solution bottle and shake the container thoroughly.

  • In ophthalmology, bacteriophage is used by instilling 1-2 drops of solution into the conjunctival sac.
  • In otorhinolaryngology, 2-3 drops are instilled into the ear, the nasopharyngeal mucosa is irrigated, and the drug solution is used to gargle.
  • In pulmonology, the drug can be used in the form of inhalation using a compressor inhaler, as well as oral administration of the drug (a more detailed description is given below).
  • In gynecology, it is used by introducing a solution of the drug into the vaginal cavity in the order of ml.
  • In urology - by introducing the drug into the bladder through a catheter, washing the urethra; in the case of pyelonephritis, the drug is taken only orally.
  • For diseases of the gastrointestinal tract, the solution is taken orally and in the form of enemas.
  • In surgery, staphylococcal bacteriophage is used for washing wounds, infected cavities (after removing the purulent contents, an amount of solution is administered slightly less than the volume of the substance removed from the wound), draining surgical wounds with tampons soaked in a solution of staphylococcal bacteriophage.

Analogs for the drug “Staphylococcal Bacteriophage” will be described below.

You need to know that if any antiseptics were used to wash the infected area, then before using the bacteriophage, these areas must be washed with sterile physiological solution of sodium chloride 0.9%. For purulent lesions of the skin and its layers, injections of the desired area with a sterile solution, lotions and applications are used. This is how “Staphylococcal bacteriophage” is used for Staphylococcus aureus.

In case of generalized infection, the drug is used orally as part of complex therapy. In order to prevent acute respiratory infections and acute respiratory viral infections, the mucous membranes of the nasal and oral cavity are irrigated several times a day and in contact with a large number of people.

For the most effective treatment, along with external use, “Staphylococcal Bacteriophage” is taken orally.

How to use? More on this later.

The exact dosage of the drug depends on the age of the patient, the location and method of administration of the drug, and the severity of the pathological process. Can be used for children from the very first hours of life. The duration of treatment also depends on the degree of advanced disease and varies from 1 week to 1 month. In case of relapses, the drug can be used repeatedly throughout the year.

It should be noted that this article is for informational purposes only. For correct and effective treatment, prescription and compliance with exact dosages and appropriate use of the drug, you should seek help from a doctor. This is confirmed by the instructions for the medication “Staphylococcal Bacteriophage”.

For children, this requirement must be met first.

Contraindications

A contraindication to the use of the described drug can only be individual intolerance to the components of the drug. There are no other contraindications.

No side effects were detected.

Overdose: To date, there has been no information about overdose.

Storage conditions and features: in a dark place at a temperature from +2 0 C to +8 0 C. It is necessary to know the rules for working with drugs containing living organisms, namely: keep your hands sterile, keep the bottle cap (open only with clean hands), put the lid on only on the outer part; use a syringe with a sterile needle to pierce the cap of the bottle in order to remove the required part of the drug; do not allow any particles to enter the bottle.

If the solution is clear and has no sediment, it can be used throughout its shelf life.

This is how staphylococcal bacteriophage is used for Staphylococcus aureus, among others.

Impact on the ability to drive vehicles

At the moment, there is no data on the harmful effects of bacteriophages on a person’s ability to drive vehicles, as well as automated mechanisms.

Available from pharmacies without a prescription.

Advantages and features of bacteriophages

“Staphylococcal Bacteriophage” collects only good reviews, because:

  • bacteriophages practically do not cause allergic reactions, which allows their use when it is impossible to use antibacterial drugs;
  • unlike antibiotics, bacteriophages do not cause resistance in microorganisms;
  • do not destroy the microflora of the human body;
  • do not have a teratogenic effect, i.e., can be used for treatment in pregnant women (as prescribed by a specialist);
  • form local immunity;
  • can be used simultaneously with other drugs, including antibiotics.

This is confirmed by the instructions for the drug “Staphylococcal Bacteriophage”. It is also absolutely safe for children.

Application of the solution using an inhaler

A solution of staphylococcal bacteriophage can be used in a compressor inhaler. This method can be used for pharyngitis, tracheitis, bronchitis, pneumonia caused by staphylococcus.

How are inhalations of “Staphylococcal Bacteriophage” carried out?

A number of rules must be followed:

  • the solution should be at room temperature (high temperature inactivates the drug);
  • should be diluted in a 1:1 ratio with a sterile solution of sodium chloride 0.9%;
  • It is necessary to maintain the cleanliness of the mask used and the inhaler chamber to prevent mixing of the bacteriophage with other substances that can cause inactivation of the drug.

“Staphylococcal bacteriophage”: analogues

There are bacteriophages to other, no less dangerous pathogens, such as streptococcus, salmonellosis, Pseudomonas aeruginosa, etc., but they have no effect on staphylococcus.

Staphylococcal bacteriophage is included in the combination drug “Sextaphage” along with several other bacteriophages. There are several other combination drugs, for example Piobacteriophage.

The price for the drug “Staphylococcal Bacteriophage” will be presented below.

Other forms of release of staphylococcal bacteriophage

  • Tablets with pectin, which are convenient for children to take to prevent acute respiratory and viral infections at the height of illness.
  • Suppositories (the advantage is ease of use: they are much easier to use than enemas and douching).
  • Ointment for external use. In some cases, it is also more convenient and easier to apply it to the damaged area and fix it there.

Price for this drug

So, the price for the drug “Staphylococcal Bacteriophage” varies by region: from 756 rubles. up to 1016 rub. for 100 ml, from 665 rub. up to 957 rub. for 4 bottles of 20 ml.

For example, in Tomsk 100 ml costs 756 rubles, and in St. Petersburg – 1016 rubles, in Moscow – 804 rubles, in Chelyabinsk – 786 rubles.

Thus, bacteriophages can rightfully be called a safe and effective means in the fight against pathogenic bacteria, which has a number of advantages over other drugs aimed at combating pathogens.

Source: http://www.syl.ru/article/303910/undefined

Staphylococcal bacteriophage

Staphylococcal bacteriophage: instructions for use and reviews

Latin name: Bacteriophagum Staphylococcum

Active ingredient: Staphylococcal bacteriophage (Bacteriophagum staphylococcum)

Manufacturer: Biopharma (Ukraine), NPO Microgen (Russia), Biomed (Russia)

Update of description and photo: 11/15/2017

Prices in pharmacies: from 663 rubles.

Staphylococcal bacteriophage is a medical immunobiological preparation for the treatment of diseases caused by staphylococci.

Release form and composition

Dosage form – solution for oral, local and external use: transparent yellow liquid of varying intensity (20 ml bottles, 4 or 8 bottles in a cardboard box; 100 ml bottles, 1 bottle in a cardboard box).

1 ml of solution contains:

  • active substance: sterile filtrate of phagolysates of bacteria of the genus Staphylococcus – up to 1 ml;
  • additional component: preservative 8-hydroxyquinoline sulfate or 8-hydroxyquinoline sulfate monohydrate.

Pharmacological properties

Staphylococcal bacteriophage is a drug that has a specific bactericidal effect against staphylococci - strains that are most significant in the etiology of the development of inflammatory and purulent diseases.

The drug causes specific lysis (dissolution) of bacteria of the genus Staphylococcus. The mechanism of its action is due to the ability of phage particles to attach to the membrane of sensitive bacteria, penetrate into cells and multiply at the expense of their resources, as a result of which these cells die and mature phage particles are released, which can infect other sensitive bacterial cells.

Staphylococcal bacteriophage does not affect other bacteria and does not disrupt the natural microflora.

Indications for use

Staphylococcal bacteriophage is intended for the treatment and prevention of purulent-inflammatory and enteral diseases caused by Staphylococcus bacteria. Particularly applicable in the following cases:

  • generalized septic diseases;
  • surgical infections: abscess, boils, carbuncles, felons, hidradenitis, phlegmon, burns, wound suppuration, bursitis, paraproctitis, osteomyelitis, mastitis;
  • intestinal dysbiosis;
  • enteral infections (gastroenterocolitis, cholecystitis);
  • diseases of the ENT organs, respiratory tract and lungs: tonsillitis, laryngitis, pharyngitis, inflammation of the middle ear and sinuses, tracheitis, pleurisy, bronchitis, pneumonia;
  • urogenital infections: colpitis, salpingoophoritis, endometritis, cystitis, urethritis, pyelonephritis;
  • purulent-inflammatory diseases of newborns, including sepsis, gastroenterocolitis, pyoderma, omphalitis, conjunctivitis;
  • other diseases caused by staphylococci.

For preventive purposes, staphylococcal bacteriophage is also used to treat wounds (postoperative and newly infected).

According to epidemic indications, it is prescribed for the prevention of nosocomial infections.

Contraindications

According to the instructions, Staphylococcal Bacteriophage is contraindicated in cases of hypersensitivity or intolerance to the components of the drug.

Instructions for use of Staphylococcal Bacteriophage: method and dosage

The solution is used orally, rectally, in the form of applications and irrigations, for administration into the cavities and sinuses of the nose, into the cavities of the vagina and uterus, as well as into drained cavities.

Before use, the bottle should be shaken and inspected for any cloudiness or sediment.

Recommended single doses for oral administration of Staphylococcal Bacteriophage depending on age:

  • 0–6 months – 5 ml;
  • 6–12 months – 10 ml;
  • 1–3 years – 15 ml;
  • 3–8 years – 15–20 ml;
  • from 8 years and older – 20–30 ml.

Recommended single doses for rectal use of Staphylococcal Bacteriophage depending on age:

  • 0–6 months – 5–10 ml;
  • 6–12 months – 10–20 ml;
  • 1–3 years – 20–30 ml;
  • 3–8 years – 30–40 ml;
  • from 8 years and older – 40–50 ml.

For intestinal dysbiosis and enteral infections, the solution is taken orally 3 times a day, an hour before meals. It is also possible to use the following treatment regimen: 2 times a day oral administration and 1 time per day rectal administration of a single dose appropriate for age, in the form of an enema after bowel movement.

For the treatment of urethritis, cystitis and pyelonephritis, the bacteriophage is prescribed orally. If the cavity of the renal pelvis or bladder is drained, the drug is administered through a nephrostomy or cystostomy 1-2 times a day, 5-7 ml into the renal pelvis or 20-50 ml into the bladder.

For purulent-inflammatory diseases with localized lesions, the drug is prescribed both locally and orally: 2-3 times a day 1 hour before meals for 7-20 days (depending on the clinical situation).

Methods of using Staphylococcal Bacteriophage depending on the nature of the source of infection:

  • in the form of tamponing, lotions and irrigation in a volume of up to 200 ml (depending on the size of the affected area). For osteomyelitis, after surgical treatment, the solution is poured into the wound in an amount of 10–20 ml. In case of an abscess, after removal of purulent exudate, the drug is administered by puncture in a volume less than the amount of removed contents;
  • in the form of instillation, washing, rinsing, introducing moistened turundas. For purulent-inflammatory diseases of the ENT organs, the drug is administered 2–10 ml 1–3 times a day. Turundas soaked in the solution are administered for 1 hour;
  • injection into cavities (articular, pleural and other organic cavities) in a volume of up to 100 ml. Subsequently, capillary drainage is left, through which the bacteriophage is introduced for several more days;
  • insertion into the cavity of the vagina and uterus. For purulent-inflammatory diseases, the drug is administered 5–10 ml once a day; for colpitis, it is used in the form of tampons 2 times a day for 2 hours or 10 ml in the form of irrigation.

In cases where chemical antiseptics were used to treat wounds before prescribing the bacteriophage, the wounds must be thoroughly washed with a sterile solution of sodium chloride 0.9%.

Use of bacteriophage in children under 6 months

For enterocolitis and sepsis in newborns, including premature infants, Staphylococcal bacteriophage is used in the form of high enemas (through a catheter or gas outlet tube) of 5–10 ml 2–3 times a day. If the child is not vomiting or regurgitating, the bacteriophage can be given orally, mixed with breast milk. A combination of oral and rectal administration is possible. The duration of therapy is from 5 to 15 days. In case of recurrent course of the disease, repeat courses are carried out.

To prevent enterocolitis and sepsis in cases of intrauterine infection or the risk of developing a nosocomial infection, the drug is used in the form of enemas 2 times a day for a course of 5–7 days.

For infected wounds, pyoderma and omphalitis, the staphylococcal bacteriophage is used in the form of applications: a gauze cloth moistened with a solution is applied to the affected area of ​​the skin or the umbilical wound 2 times a day.

Side effects

The drug does not cause side effects.

Overdose

There were no cases of overdose.

special instructions

An important condition for effective phage therapy is determining the sensitivity of the pathogen to the bacteriophage and prescribing the drug as early as possible after the appearance of purulent-inflammatory signs.

In case of severe manifestations of infection, staphylococcal bacteriophage is used as part of complex therapy.

The drug contains a nutrient medium in which bacteria from the environment can develop, causing the solution to become cloudy. In this regard, the following rules of use and storage must be observed:

  • wash your hands thoroughly;
  • treat the cap with an alcohol-containing product;
  • do not place the cork on the table or other objects with the inner surface;
  • do not leave the bottle open;
  • After opening the bottle for the first time, store the drug only in the refrigerator.

After opening the bottle, provided that the listed rules are followed and there is no cloudiness, the drug can be used throughout the expiration date.

The required amount of solution should be removed from the bottle using a sterile syringe by piercing the stopper.

It is prohibited to use Staphylococcal Bacteriophage if the shelf life of the drug has expired, the solution has become cloudy, or the labeling or integrity of the bottle has been damaged.

Impact on the ability to drive vehicles and complex mechanisms

Use during pregnancy and lactation

Staphylococcal bacteriophage can be used as prescribed by a doctor during pregnancy and lactation in the presence of infections caused by phage-sensitive strains of staphylococci.

Use in childhood

There are no age restrictions for the use of the drug.

Drug interactions

Can be used in combination with other drugs, including antibiotics.

Analogs

There is no information on analogues of Staphylococcal Bacteriophage.

Terms and conditions of storage

Store and transport in accordance with Sanitary and Epidemiological Rules 3.3.2. in a place protected from light at a temperature of 2–8 °C. Transportation is allowed in temperature conditions of 9–25 °C, but not more than 1 month. Keep away from children.

Shelf life – 2 years.

Conditions for dispensing from pharmacies

Available without a prescription.

Reviews of Staphylococcal Bacteriophage

Reviews about Staphylococcal Bacteriophage are mostly positive. Patients confirm the high effectiveness of the drug in the fight against diseases caused by staphylococci, and consider it a worthy and safer alternative to antibiotics.

However, there are also individual reviews that indicate that the bacteriophage was ineffective and even caused side effects (diarrhea, increased body temperature), although the instructions indicate that the drug was very well tolerated and there were no unwanted reactions.

The disadvantages of almost all patients include the high cost of Staphylococcal Bacteriophage and its unpleasant taste, as well as the inconvenience of storage (in the refrigerator) and use (the need to draw the solution with a sterile syringe to maintain asepsis).

Price for Staphylococcal Bacteriophage in pharmacies

Prices for Staphylococcal Bacteriophage are 630–795 rubles for a package of 4 bottles of 20 ml, 710–1165 rubles for 1 bottle of 100 ml.

Bacteriophage staphylococcal solution 20 ml 4 pcs.

Bacteriophage staphylococcal liquid 20ml No. 4 bottles

Bacteriophage staphylococcal solution 100 ml

Staphylococcal bacteriophage 20ml N4

Staphylococcal bacteriophage 100ml

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

It was previously believed that yawning enriches the body with oxygen. However, this opinion has been refuted. Scientists have proven that yawning cools the brain and improves its performance.

Each person has not only unique fingerprints, but also tongue prints.

Regular use of a solarium increases your chance of developing skin cancer by 60%.

The human brain weighs about 2% of the total body weight, but it consumes about 20% of the oxygen entering the blood. This fact makes the human brain extremely susceptible to damage caused by a lack of oxygen.

According to WHO research, talking on a mobile phone for half an hour every day increases the likelihood of developing a brain tumor by 40%.

Most women are able to derive more pleasure from contemplating their beautiful body in the mirror than from sex. So, women, strive to be slim.

When we sneeze, our body stops working completely. Even the heart stops.

In 5% of patients, the antidepressant Clomipramine causes orgasm.

There are very interesting medical syndromes, for example, compulsive swallowing of objects. One patient suffering from this mania had 2,500 foreign objects in her stomach.

Smiling just twice a day can lower your blood pressure and reduce the risk of heart attacks and strokes.

American scientists conducted experiments on mice and came to the conclusion that watermelon juice prevents the development of vascular atherosclerosis. One group of mice drank plain water, and the second group drank watermelon juice. As a result, the vessels of the second group were free of cholesterol plaques.

The rarest disease is Kuru disease. Only members of the For tribe in New Guinea suffer from it. The patient dies of laughter. The disease is believed to be caused by eating human brains.

Over the course of a lifetime, the average person produces no less than two large pools of saliva.

Human blood “runs” through the vessels under enormous pressure and, if their integrity is violated, it can shoot at a distance of up to 10 meters.

Dentists appeared relatively recently. Back in the 19th century, pulling out diseased teeth was the responsibility of an ordinary hairdresser.

Every time a child has a fever, a sore throat, a runny nose and a cough, parents are worried about the question - is it a common cold or the flu? In this

Source: http://www.neboleem.net/bakteriofag-stafilokokkovyj.php