Bacteriophage microgen

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Bacteriophage staphylococcal Microgen liquid - reviews

Helped excellently in the treatment of chronic tonsillitis.

Advantages: Does not kill beneficial bacteria, acts directly only on staphylococci. They are easy to treat tonsillitis.

Table of contents:

Disadvantages: Price) and not every pharmacy has it, you need to look for it.

My child has chronic tonsillitis. The exacerbations were very frequent. Last year we were sick 9 or 8 times. Every now and then we missed school and SAMBO. Often treatment was not possible without antibiotics. No prophylactic rinses were given.

Cures all types of staphylococcus, but it got us into a little trouble

Advantages: Effective on all types of staphylococcus

Disadvantages: Caused side effects

At three weeks my baby broke out in a rash, first we were treated for allergies, then for dysbacteriosis, and at four months after a visit to the dermatologist, my baby was diagnosed with Staphylococcus aureus, first on the skin, but...

Cured Staphylococcus aureus in my infant daughter.

Advantages: helped get rid of staphylococcus

Disadvantages: bad taste

Ever since the maternity hospital, my daughter began to suffer with her tummy and cried a lot. We lay there for quite a long time, two weeks, as the birth was difficult. After the maternity hospital, my daughter stopped breastfeeding because she was in the maternity hospital.

remedy for chronic diseases

Advantages: gentle treatment without antibiotics, virtually no side effects, effective when prescribed correctly

Disadvantages: price, taste, drug supply via a syringe, confusing instructions for the drug

Today I want to talk about the drug staphylococcal Bacteriophage. For those who do not know what a bacteriophage is. This is a specially designed virus that penetrates inside a bacterial cell, synthesizes its phages (“eaters”) in it, then they leave the bacterial cell.

Russia, Temporarily inactive

Who is this instruction for? For patients with a dictionary?

Pros: Sold without a prescription

Disadvantages: Doesn't help immediately. Terribly unclear instructions. Price.

It all started after another ENT procedure for washing the tonsils, when the otolaryngologist recommended doing a flora culture to determine sensitivity to an extended range of antibiotics and bacteriophages. Material for analysis is obtained by taking a throat swab. The analysis is done on an empty stomach.

A skin rash does not always mean an allergy

Disadvantages: price is high

We are currently completing the first course of taking staphylococcal bacteriophage. And I can already share my impressions. The fact is that my daughter was a month old when her first allergy appeared. I thought about my diet and began to exclude all kinds of allergens.

Effective treatment of staphylococcus.

Advantages: Eliminates staphylococcus, has no contraindications.

Disadvantages: Specific taste, high price.

I have been familiar with bacteriophages since the time when my eldest daughter had dysbacteriosis and, as a result, had an allergic reaction. Then we assessed how effectively pyobacteriophage (sextaphage) http://otzovik.com/review_760827.html works. And so, when the youngest turned six.

There are features in storage and use

Advantages: There is no harmful effect on the body, like antibiotics.

Disadvantages: Very high, heavily inflated price for a small dosage.

Bacteriophages appeared around the same time as antibiotics, but, unfortunately, they were not widely used due to the high prospects of antibiotic therapy. But people are increasingly faced with resistance of various types of bacteria to antibiotics, and more and more are appearing.

An effective remedy

Pros: Good result

Disadvantages: Expensive, hard to find in pharmacies, can only be stored in the refrigerator.

My eight-year-old child has had a constantly congested throat since he was four. For a long time they could not find the reason, but in the end they advised me to get tested for viruses and cultured staphylococcus. The ENT doctor prescribed treatment, of course it included an antibiotic. I must say lore.

We haven’t completely defeated the child’s staphylococcus!

Advantages: Facilitates the general condition, the best composition.

Disadvantages: Staphylococcus was not cured, very high cost

I never thought that I would have to deal with bacteriophages, I had never even heard that name, but I was unlucky - Staphylococcus aureus was discovered in a small child at two months old in his stool. Apparently we earned it in the family home.

Effectively

Advantages: Efficiency proven from personal experience

Disadvantages: Unpleasant taste, expensive.

My throat began to hurt very much. I used advertised sprays, lozenges, and lozenges. Everything is in vain. I tried folk remedies - no results. I decided to go to the doctor. The doctor ordered a microflora analysis (throat swab). It turned out that I have.

They treated dysbiosis with it, but did not cure it

Pros: Didn't find any

Disadvantages: Inconvenient to use, nasty taste, high price

My child fell ill with dysbiosis while still in the maternity hospital. I had a caesarean section and was given antibiotics for five days. They were passed on to the baby through the milk. As a result, both I and he have dysbacteriosis. This disease was discovered upon delivery.

Excellent product, helped us 100%

Advantages: The child stopped getting sick, the mother is happy.

Disadvantages: The price is steep, it’s hard to find in Ukraine.

I’ll start the story with the fact that my son is 5 years old. We've been trying to go to kindergarten since we were two years old, but that's the point: we're just trying. When the baby started snoring, we went to the ENT specialist, he...

Cures Staphylococcus aureus.

Disadvantages: Inaccessibility, storage problem.

In addition to Klebsiella, my baby was diagnosed with Staphylococcus aureus, and after treatment with Klebsella bacteriophage, he underwent a course of staphylococcal. It is also difficult to find; storage conditions, temperature conditions and sterility must be strictly observed. I also use this drug.

not tasty, disgusting. but effective

Pros: Helped, no side effects

Disadvantages: Needs to be stored in the refrigerator, cannot be heated, expensive

The bacteriophage was prescribed to the child by a gastroenterologist after analyzing stool for opportunistic pathogenic flora. Staphylococcus was found in quite large quantities. A course was prescribed for 5 days. 5 ml 2 times a day before meals and 1 time.

A WORTHY ALTERNATIVE TO ANTIBIOTICS!

Advantages: They have no side effects, REALLY HELP, bacteriophage viruses only act on the microorganism that causes the disease.

Disadvantages: Not pleasant to the taste, salty.

Since my son has chronic tonsillitis, he often had a sore throat and was prescribed antibiotics every time. In addition to a sore throat, immediately after vaccination (DTP), he fell ill with whooping cough (he coughed for 2 years with vomiting for the first time), doctors attributed everything to chronic bronchitis.

A very expensive product, but it helped!

Pros: Helped, no chemicals

Disadvantages: expensive, unpleasant taste and smell (it is necessary to restore the microflora)

Literally from the age of 2 weeks the baby began to have problems - constant crying, poor nutrition, lack of weight gain, colic. After prolonged suffering, we were told to take the necessary tests for lactose deficiency (LD) and dysbacteriosis. The tests confirmed it.

helps

Disadvantages: price, taste, storage, use

As I already wrote, my son has been constipated since birth. I tried everything the pediatrician said, including diet, but still the baby had independent bowel movements once every 7-8 days. The analyzes were in.

helped get rid of Staphylococcus aureus

Advantages: Has no contraindications, the drug can be used with any other medicine

My two-year-old child was tested for dysbiosis and was diagnosed with Staphylococcus aureus and untreated dysbiosis. We did the analysis for a fee and at the same time did a phage sensitivity test. This sensitivity test has already been written about.

Do not give to small children!

Disadvantages: Didn't serve its purpose! Gives severe side effects after two days of use!

Mothers of small children under three years old! Be very careful with this drug! The first time I gave it to my baby was six months old. Staphylococcus aureus was cultured in the stool. At an appointment with a gastroenterologist, they were not offered to drink this.

Source: http://otzovik.com/reviews/bakteriofag_stafilokokkoviy_mikrogen_zhidkiy/

Bacteriophage Staphylococcal

Description current as of 02/20/2015

  • Latin name: Bacteriophagum Staphylococcum
  • ATX code: J01XX
  • Active ingredient: Staphylococcal bacteriophage (Bacteriophagum staphylococcum)
  • Manufacturer: Biopharma (Ukraine), NPO Microgen (Russia), Biomed (Russia)

Compound

The active component of the drug Staphylococcal Bacteriophage is an anti-staphylococcal bacteriophage in liquid form, in the form of suppositories, ointments or tablets.

Release form

  • 50 or 100 ml of such a solution in a bottle - one bottle in a cardboard box.
  • 20 ml of this solution in a bottle - four bottles in a cardboard box.
  • 25 ml of such a solution in an aerosol package - one package in a cardboard box.
  • 10 and 20 grams of ointment in a bottle, one bottle in a cardboard box.
  • 10 candles per package, one package in a cardboard box.
  • 10, 25 and 50 tablets per package, one package in a cardboard box.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

What is a Bacteriophage?

This drug is relatively new on the drug market and many patients have a natural question: “Bacteriophage - what is it?”

Bacteriophages are viral particles that kill only certain types of pathogenic bacteria. On their basis, appropriate drugs are created. The discovery of the drugs belongs to the Canadian scientist Felix D'Herelle.

Structure of Bacteriophages

An ordinary bacteriophage consists of a tail and a head. The tail is usually 3-4 times longer than the diameter of the head. The head contains double-stranded or single-stranded RNA or DNA with an inactive transcriptase, surrounded by a shell of protein or lipoprotein called the capsid.

Reproduction of Bacteriophages

As with conventional viruses, the reproduction cycle of lytic bacteriophages can be divided into adsorption of the phage on the cell wall, introduction of DNA, reproduction of the phage, and evacuation of daughter populations from the cell.

Attachment of the phage to the bacterial cell occurs due to its surface structures, which serve as specific receptors for viruses. In addition to receptors, phage attachment depends on temperature, acidity of the environment, the presence of cations and a number of other compounds. Up to 300 virus particles can be adsorbed on one cell.

After attachment, the cell wall is broken down by lysozyme enzymes. At the same time, calcium ions are released, activating ATPase - this causes contraction of the sheath and insertion of the tail shaft into the cell. The viral DNA is then injected into the cytoplasm. Having penetrated the bacterium, the phage DNA takes control of the cell’s genetic apparatus, carrying out the phage’s reproductive cycle.

First of all, the synthesis of enzymes necessary for the formation of copies of phage DNA (DNA polymerase, thymidylate synthetase, kinase) occurs. It takes 5-7 minutes from the moment of infection. The cell's RNA polymerase converts viral DNA into mitochondrial RNA, which is translated by ribosomes into early proteins. “Early” proteins are mainly viral RNA polymerase and proteins that limit the expression of bacterial genes. The viral RNA polymerase transcribes the so-called “late” proteins necessary for the assembly of new phage particles.

The reproduction of nucleic acids occurs due to the activity of synthesized DNA polymerases of the virus. By the end of the cycle, the components of the phage are combined into a mature virion.

Evacuation of Bacteriophage populations from the cell

Newly biosynthesized proteins in the cytoplasm form a pool of precursors. The other pool includes the DNA of the offspring. Specialized regions in the viral DNA induce the association of these proteins around groups of nucleic acid molecules and the synthesis of new heads. The head interacts with the tail to form a daughter phage. After the offspring are released, the host cell is destroyed, releasing a new population.

An alternative to cell destruction may be an integrative form of interaction in which the phage DNA, instead of replication, is integrated into the bacterial chromosome or becomes a plasmid. As a result, the viral genome replicates along with the host DNA.

Types of Bacteriophages

The use of bacteriophages determines their clinical classification. Based on this thesis, the following types of bacteriophages can be distinguished:

  • bacteriophages for the treatment of intestinal infections: dysentery, polyvalent, salmonella ABCDE-group, typhoid, coliproteus, intesti-bacteriophage (a mixture of phages against the most common pathogens of intestinal infections);
  • bacteriophages for the treatment of purulent-septic lesions: Klebsiella pneumoniae, Klebsiella polyvalent, Pseudomonas aeruginosa, antistaphylococcal bacteriophage, coli, Proteus, streptococcal, combined pyobacteriophage (a mixture of phages that destroy most likely pathogens of infections of a purulent-septic nature).

The use of bacteriophage preparations in medicine is becoming increasingly widespread due to the increasing incidence of polyvalent resistance of pathogens to antibacterial agents.

Indications for use

How to take this medicine? The drug is used for the treatment and prevention of diseases caused by staphylococcus:

Contraindications

There are no contraindications to the use of this product.

Side effects

Adverse reactions to the administration of the drug have not been established.

With the intradermal route of administration, short-term hyperemia and inflammation are possible.

Instructions for staphylococcal bacteriophage (Method and dosage)

The drug is injected into the site of infection. The frequency of injections and their size are determined by determining the clinical form of the disease, the nature of the infectious focus and standard recommendations. The average duration of treatment is 5-15 days. In cases of relapse, additional courses of treatment are possible. Instructions for using staphylococcal bacteriophage for children and adults are somewhat different. Recommendations for the use of the drug for children are given at the end of the section.

Liquid phage is allowed to be used topically in the form of lotions, irrigation or tamponing in a volume of up to 200 ml, taking into account the size of the affected area. An ointment is also available for topical use.

It is advisable to carry out therapy of purulent-inflammatory limited lesions both locally and orally for 1-4 weeks.

For purulent-inflammatory lesions of the throat, ear or nose, the drug is used for rinsing, instilling, washing and administering moistened turundas 2-10 ml up to three times a day.

For carbuncles and boils, liquid bacteriophage is injected directly into or around the lesion, 0.5-2 ml daily. In total, up to 5 injections are given per course of treatment.

Treatment of chronic osteomyelitis is carried out by infusion of the drug into the wound immediately after surgical treatment.

In case of abscesses, the bacteriophage is injected into the cavity of the lesion, emptied of pus. When opening an abscess, a tampon moistened with the drug is inserted into the wound.

Treatment of deep pyodermatitis is carried out by making intradermal injections of the drug into one place of 0.1-0.5 ml or into several places in a total dose of up to 2 ml. Administration is carried out every 24 hours, a total of 10 injections.

For administration into the abdominal, pleural, and articular cavities, capillary drainage is used, and up to 100 ml of bacteriophage is injected every other day. There are only 3-4 such introductions.

For cystitis, the drug is injected into the bladder using a catheter.

For purulent bursitis, pleurisy or arthritis, the drug is administered into a cavity previously emptied of pus, 20 ml every other day. The course of treatment is 3-4 administrations.

Also, Staphylococcal bacteriophage is used orally in the form of tablets in the treatment of urogenital infections (cystitis, pyelonephritis, pyelitis, salpingoophoritis, endometritis), intestinal infections and other diseases caused by staphylococcus.

How to use Staphylococcal Bacteriophage for intestinal staphylococcal lesions and intestinal dysbiosis: the drug is used orally on an empty stomach three times a day, 2 hours before meals; The drug is prescribed rectally in the form of suppositories or enemas once a day. Treatment lasts 7-10 days.

For newborn children, the drug is diluted with an equal amount of water in the first 2 doses. It can also be mixed with breast milk.

For sepsis or enterocolitis in newborns, the drug is used by performing high enemas up to three times a day. A combination of rectal and oral use is permitted.

When treating pyoderma, omphalitis, purulent wounds in newborns, the drug is used in the form of applications twice a day and in the form of tablets - 1 piece up to four times a day. The ointment is used locally with bandages of 5-20 grams up to two times a day.

For the prevention of enterocolitis and sepsis in newborns, when there is a risk of developing a hospital infection or intrauterine infection, the drug is used in the form of enemas twice a day for a week.

In aerosol form, Staphylococcal Bacteriophage is used to irrigate affected mucous membranes and skin for purulent-inflammatory lesions, burns, septic wounds and sore throat.

The most justified use of this remedy is in cases of infection with antibiotic-resistant strains.

Overdose

Such cases have not been studied.

Interaction

If antiseptic solutions (not including furatsilin) ​​were used before local application of the product, the affected area should be washed with saline solution or 3% sodium bicarbonate solution.

Terms of sale

Dispensing of the drug is permitted without a prescription.

Storage conditions

Store at a temperature of 2-10 degrees in a dark place. Keep away from children.

Best before date

special instructions

Treatment with the drug should be started as early as possible.

The drug must be shaken before use; a cloudy solution should not be used.

When opening the bottle, storing and sampling the product, the following rules should be observed:

  • hands must be washed thoroughly;
  • Before removing, the cap must be treated with an alcohol solution;
  • the cap should be removed without removing the stopper;
  • the drug should be removed from an opened bottle only by piercing the stopper with a sterile syringe;
  • If, during opening, the cork was accidentally uncorked along with the cap, then it should not be placed with the inner surface on the table, and the bottle should not be left open (after taking the product, it must be closed with the cork);
  • It is recommended to store the opened bottle in the refrigerator.

Subject to compliance with the specified rules and in the absence of turbidity, the product from the opened bottle can be used throughout the entire shelf life.

Analogs

For children

The drug is approved for use in newborns and children of all ages.

With antibiotics

During pregnancy and lactation

It is possible to use the product during the specified periods under the supervision of the attending physician.

Reviews of Staphylococcal Bacteriophage

Despite many cases of cure, the therapeutic effect of taking the drug is not guaranteed in all cases. This is evidenced by reviews of Staphylococcal Bacteriophage. This feature is more often detected when the product is used for newborns and young children.

The effectiveness of the drug may vary depending on the sensitivity of the particular strain to the phage and other factors that should be determined before starting treatment.

In some situations, parents prematurely stop the course of treatment for their infant, frightened by the supposedly worsening symptoms of the disease, and then report that the drug did not work on the child. In any case, before deciding to undergo therapy with this medicine, and during treatment, you should be observed by your doctor and clarify all unclear questions with him.

Staphylococcal Bacteriophage price, where to buy

In Ukraine, the price of the drug Staphylococcal Bacteriophage liquid 100 ml produced by the Biopharma company (Kiev) averages 318 hryvnia.

In Russia, the price of staphylococcal and polyvalent Pyobacteriophage liquid bacteriophage in standard packaging of 20 ml No. 4 is almost the same and amounts to rubles.

Buying a staphylococcal bacteriophage in Moscow (manufactured by NPO Microgen, Nizhny Novgorod) will cost rubles per 100 ml bottle.

Such drugs are almost never found in tablet or suppository forms in pharmacies.

  • Online pharmacies in Russia Russia

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ZdravZone

Pharmacy IFC

Education: Graduated from Vitebsk State Medical University with a degree in Surgery. At the university he headed the Council of the Student Scientific Society. Advanced training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".

Work experience: Worked in a general medical network for 3 years as a surgeon (Vitebsk Emergency Hospital, Liozno Central District Hospital) and part-time as a district oncologist and traumatologist. Worked as a pharmaceutical representative for a year at the Rubicon company.

Presented 3 rationalization proposals on the topic “Optimization of antibiotic therapy depending on the species composition of microflora”, 2 works took prizes in the republican competition-review of student scientific works (categories 1 and 3).

Inna: Usually, insomnia occurs for me due to some kind of experience and when you lie down, it’s not.

Olesya: I tried glycine forte, which is more expensive in the price category, but the dosage is the same.

Andrey: Not a word is said about choosing the size of stockings according to a person’s parameters: height, leg size, etc.

Olga: For coxarthrosis of the 2nd degree, I have been injecting for 4 years at the rate (after 6 months), there is no improvement.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/bakteriofag-stafilokokkovyiy

Bacteriophages "NPO Microgen" Ministry of Health of Russia Brief information

Bacteriophages are modern antimicrobial drugs containing a complex of natural antibacterial agents that have the ability to act only on harmful bacteria. Bacteriophages, which literally means “bacteria eaters,” are special viruses that can reproduce only in the presence of a certain type of pathogenic bacteria.

Bacteriophages are an effective alternative to antibiotics, while bacteriophages do not inhibit their own microflora, are non-toxic, non-reactogenic, help normalize immunity, and are compatible with any medications. An important condition for effective phage therapy is the preliminary determination of the phage sensitivity of the pathogen and early use of the drug.

Bacteriophage dysentery polyvalent

(acid-resistant tablets)

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia

  • Release form: bottle of 50 tablets No. 10, bottle of 20 ml No. 4.
  • Scope of application: treatment and prevention of bacterial dysentery. Sanitation of convalescents (bacteria carriage).
  • Spectrum of antibacterial activity: Shigella flexneri serovars 1, 2, 3, 4, 6 and Shigella sonnei.

Delivery request

Bacteriophage Klebsiella pneumonia purified

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia

  • Release form: 20 ml bottle No. 4.
  • Area of ​​application: treatment of surgical infections, diseases of the urogenital area and gastrointestinal tract, purulent-inflammatory diseases of the ear, nose and throat, as well as sepsis of newborns and infants, for selective decontamination of the intestines.
  • Spectrum of antibacterial activity: Klebsiella pneumonia.

Delivery request

Bacteriophage Klebsiella polyvalent purified

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia

  • Release form: 20 ml bottle No. 4.
  • Area of ​​application: treatment of ozena, rhinoscleroma and purulent-inflammatory diseases. It is used to treat otitis media, inflammation of the sinuses and other purulent-inflammatory diseases of the ear, nose and throat.
  • Spectrum of antibacterial activity: Klebsiella pneumoniae, Klebsiella ozaenae, Klebsiella rhinoscleromatis.

Delivery request

Bacteriophage Coli

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia

  • Release form: 20 ml bottle No. 4.
  • Area of ​​application: treatment and prevention of infections of the skin and internal organs: purulent wounds, burns, abscesses, pleurisy, cystitis, enterocolitis, toxic infections, as well as other coli infections.
  • Spectrum of antibacterial activity: enteropathogenic Escherichia coli.

Delivery request

Bacteriophage coliproteus

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia

  • Release form: bottle 100 ml No. 1.
  • Area of ​​application: treatment and prevention of enterocolitis and treatment of colpitis of coliproteus etiology.
  • Spectrum of antibacterial activity: enteropathogenic Escherichia coli, Proteus vulgaris, Proteus mirabilis

Delivery request

Bacteriophage Proteus

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia

  • Release form: 20 ml bottle No. 4.
  • Scope of application: treatment and prevention of ENT diseases, surgical, urogenital and other infections caused by Proteus bacteria.
  • Spectrum of antibacterial activity: Proteus vulgaris and Proteus mirabilis.

Delivery request

Bacteriophage Pseudomonas aeruginosis (pseudomonas)

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia

  • Release form: 100 ml bottle No. 1, 20 ml bottle No. 4.
  • Area of ​​application: treatment of diseases of various organs and purulent skin infections; for the treatment of abscesses, surgical infections, purulently complicated wounds, cystitis, etc.
  • Spectrum of antibacterial activity: Pseudomonas aeruginosa.

Delivery request

Salmonella bacteriophage groups A, B, C, D, E

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia

  • Release form: bottle 100 ml No. 1, bottle 50 tablets No. 10.
  • Area of ​​application: treatment and prevention of salmonellosis.
  • Spectrum of antibacterial activity: Salmonella serogroups:

— A (Salmonella paratyphi A),

— B (S. paratyphi B, S. typhimurium, S. Heidelberg),

- C (S. newport, S. choleraesuis, S. oranienburg, S. Infantis),

— D (S. dublin, S. Enteritidis),

Staphylococcal bacteriophage

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia

  • Release form: 20 ml bottle No. 4, 100 ml bottle No. 1.
  • Scope of application: treatment and prevention of purulent-inflammatory infections of the skin and mucous membranes; for the treatment of cystitis, cholecystitis, acute tonsillitis, enterocolitis and other infections caused by staphylococci.
  • Spectrum of antibacterial activity: Staphylococcus aureus and a number of other types of coagulase-negative staphylococci.

Delivery request

Streptococcal bacteriophage

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia

  • Release form: 20 ml bottle No. 4.
  • Area of ​​application: treatment and prevention of purulent-inflammatory and enteral diseases, dysbiosis. Treatment of postoperative and newly infected wounds, incl. prevention.
  • Spectrum of antibacterial activity: Streptococcus, Enterococcus.

Delivery request

Intesti-bacteriophage

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia

  • Release form: bottle 20 ml No. 4, 100 ml No. 1.
  • Area of ​​application: treatment of acute and chronic diseases: dysentery, salmonellosis, dyspepsia, colitis, enterocolitis.
  • Spectrum of antibacterial activity: Shigella flexneri 1, 2, 3, 4, 6 serotypes, Shigella sonnei, Salmonella paratyphi A, Salmonella paratyphi B, Salmonella typhimurium, Salmonella infantis, Salmonella choleraesuis, Salmonella oranienburg, Salmonella enteritidis, enteropathogenic Escherichia coli of various serogroups, the most significant in the etiology of enteric diseases, Proteus vulgaris, Proteus mirabilis, Enterococcus, Staphylococcus, Pseudomonas aeruginosa.

Delivery request

Pyobacteriophage complex

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia

  • Release form: bottle 100 ml No. 1.
  • Scope of application: treatment and prevention of various forms of purulent-inflammatory and enteral diseases, surgical infections, burns, purulent skin lesions, cystitis and pyelonephritis, gastroenterocolitis, cholecystitis, intestinal dysbiosis, enteritis and intestinal dysbiosis of newborns and infants.
  • Spectrum of antibacterial activity: Pseudomonas aeruginosa, Proteus mirabilis, P. Vulgaris, Klebsiella pneumoniae, K. Oxytoca, Staphylococcus, Streptococcus, enteropathogenic Escherichia coli.

Delivery request

Pyobacteriophage polyvalent purified

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia
  • Release form: 20 ml bottle No. 4.
  • Scope of application: treatment and prevention of various forms of purulent-inflammatory and enteric diseases, surgical infections, burns, purulent skin lesions, cystitis and pyelonephritis, gastroenterocolitis, cholecystitis, intestinal dysbiosis, enteritis. Treatment of intestinal dysbiosis, including in newborns and infants.
  • Spectrum of antibacterial activity: Staphylococcus, Streptococcus, Pseudomonas aeruginosa, Proteus mirabilis, Proteus Vulgaris, Klebsiella pneumoniae, enteropathogenic Escherichia coli.

Delivery request

Sextaphage

FSUE NPO Microgen, Ministry of Health of the Russian Federation, Russia

  • Release form: 20 ml bottle No. 4.
  • Area of ​​application: treatment of boils, carbuncles, hydroadenitis, abscesses, purulent-complicated wounds infected with staphylococci, purulent tonsillitis, bronchitis, pleurisy, bursitis, thermal burns, chronic osteomyelitis, phlegmon, tendovaginitis, mastitis, cystitis, cholecystitis. For deep infiltrated and abscessed staphylococcal sycosis, enterocolitis, etc., as well as for prophylactic purposes: for freshly infected wounds (surgeries in the abdominal and thoracic cavities, street and industrial injuries, etc.).
  • Antibacterial activity spectrum: Pseudomonas aeruginosa, Proteus mirabilis, Proteus Vulgaris, Klebsiella pneumoniae, Staphylococcus, Streptococcus, enteropathogenic Escherichia coli.

Delivery request

Myths about vaccination

In recent years, the world has developed an ambiguous attitude towards vaccinations. Despite the fact that universal vaccination against some diseases has led to their almost complete disappearance, the ranks of opponents of mandatory vaccinations are growing. This is facilitated by widespread misconceptions regarding vaccination.

Unknown infection is the main danger

Intestinal infections, a wave of tick-borne encephalitis and southern infections brought by Russians from vacation - these are the medical results of the summer.

One of the most famous infectious disease specialists in Russia, Academician Viktor Maleev, spoke about our smallest, but no less dangerous enemies.

Vaccinations for children from birth to 7 years: recommendations for 2017

The national calendar of preventive vaccinations includes far from the most complete list of vaccines existing in the world. When compiling it, a great many factors are taken into account, and not the least role.

Comprehensive response to colds and flu

With the onset of the cold season, the incidence of acute respiratory viral infections (ARVI), influenza and other respiratory tract infections increases annually, reaching epidemic proportions at the peak of cold weather.

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Bacteriophage staphylococcal solution "Microgen"

INSTRUCTIONS for the use of the medicinal product for medical use Staphylococcal bacteriophage

Registration number. P N001973/

Name of the drug. Staphylococcal bacteriophage.

Group name. Staphylococcal bacteriophage

Dosage form. Solution for oral, local and external use.

Compound. 1 ml of the drug contains the active substance - a sterile filtrate of phagolysates of bacteria of the genus Staphylococcus up to 1 ml.

Preservative - 8-hydroxyquinoline sulfate - 0.0001 g/ml (calculated content);

or 8-hydroxyquinoline sulfate monohydrate - 0.0001 g/ml (in terms of 8-hydroxyquinoline sulfate, calculated content).

Description. The drug is a transparent yellow liquid of varying intensity.

Pharmacotherapeutic group of the drug. MIBP-bacteriophage.

Biological properties. The drug causes specific lysis of Staphylococcus bacteria.

Indications for use. Treatment and prevention of purulent-inflammatory and enteral diseases caused by bacteria of the genus Staphylococcus in adults and children.

- diseases of the ear, throat, nose, respiratory tract and lungs (inflammation of the sinuses, middle ear, sore throat, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy);

- surgical infections (suppuration of wounds, burns, abscess, phlegmon, boils, carbuncles, hydradenitis, panaritium, paraproctitis, mastitis, bursitis, osteomyelitis);

- urogenital infections (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis);

— enteral infections (gastroenterocolitis, cholecystitis), intestinal dysbiosis;

- generalized septic diseases;

- purulent-inflammatory diseases of newborns (omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc.);

- other diseases caused by staphylococci.

In case of severe manifestations of staphylococcal infection, the drug is prescribed as part of complex therapy.

For prophylactic purposes, the drug is used for the treatment of postoperative and newly infected wounds, as well as for the prevention of nosocomial infections for epidemic indications.

An important condition for effective phage therapy is the preliminary determination of the sensitivity of the pathogen to the bacteriophage and the early use of the drug.

Contraindications. Individual intolerance or sensitivity to any of the components of the drug.

Use during pregnancy and breastfeeding. It is advisable to use the drug in the presence of infections caused by phage-sensitive strains of staphylococci (on the recommendation of a doctor).

Method of administration and dose. The drug is used for oral administration (oral), rectal administration, applications, irrigation, administration into wound cavities, vagina, uterus, nose, sinuses and drained cavities. Before use, the vial with the bacteriophage must be shaken and inspected. The preparation must be transparent and free of sediment.

Recommended dosages of the drug.

Age Dose per 1 dose (ml)

6-12 months

from 1 year to 3 years

from 3 to 8 years 40

from 8 years and older50

Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by taking the drug orally 2-3 times a day on an empty stomach 1 hour before meals from the first day of the disease for 7-20 days (according to clinical indications).

If chemical antiseptics were used to treat wounds before using the bacteriophage, the wound should be thoroughly washed with a sterile sodium chloride solution of 0.9%.

Depending on the nature of the source of infection, the bacteriophage is used:

1. In the form of irrigation, lotions and tamponing in a volume of up to 200 ml, depending on the size of the affected area. In case of an abscess, after removing the purulent contents using a puncture, the drug is administered in an amount less than the volume of the removed pus. In case of osteomyelitis, after appropriate surgical treatment, the bacteriophage is infused into the wound.

2. When administered into cavities (pleural, articular and other limited cavities) up to 100 ml, after which capillary drainage is left, through which the bacteriophage is administered for several days.

3. For cystitis, pyelonephritis, urethritis, the drug is taken orally. If the cavity of the bladder or renal pelvis is drained, the bacteriophage is injected through the cystostomy or nephrostomy 1-2 times a day, poured into the bladder and 5-7 ml into the renal pelvis.

4. For purulent-inflammatory gynecological diseases, the drug is administered into the cavity of the vagina, uterus in a dose of 5-10 ml once daily, for colpitis - 10 ml by irrigation or tamponing 2 times a day. Tampons are placed for 2 hours.

5. For purulent-inflammatory diseases of the ear, throat, nose, the drug is administered in a dose of 2-10 ml 1-3 times a day. The bacteriophage is used for rinsing, washing, instilling, introducing moistened turundas (leaving them for 1 hour).

6. For enteral infections and intestinal dysbiosis, the drug is taken orally 3 times a day 1 hour before meals. It is possible to combine double oral administration with a single rectal administration of a single age-specific dose of the bacteriophage in the form of an enema after bowel movement.

Use of bacteriophage in children (up to 6 months).

For sepsis and enterocolitis in newborns, including premature babies, the bacteriophage is used in the form of high enemas (through a gas tube or catheter) 2-3 times a day in a dose of 5-10 ml. In the absence of vomiting and regurgitation, it is possible to use the drug by mouth. In this case, it is mixed with breast milk. A combination of rectal (in the form of high enemas) and oral (through the mouth) use of the drug is possible. The course of treatment is 5-15 days. In case of recurrent course of the disease, repeated courses of treatment are possible. In order to prevent sepsis and enterocolitis during intrauterine infection or the risk of nosocomial infection in newborns, the bacteriophage is used in the form of enemas 2 times a day for 5-7 days.

In the treatment of omphalitis, pyoderma, and infected wounds, the drug is used in the form of applications twice daily (a gauze pad is moistened with a bacteriophage and applied to the umbilical wound or to the affected area of ​​the skin).

Side effect. None.

Interaction with other drugs. The drug can be used in combination with other drugs, including antibiotics.

Special instructions. The drug is not suitable for use in bottles with damaged integrity or labeling, if the expiration date has expired, or if they are cloudy.

Due to the content of a nutrient medium in the drug, in which bacteria from the environment can develop, causing cloudiness of the drug, the following rules must be observed when opening the bottle:

- wash your hands thoroughly;

- treat the cap with an alcohol-containing solution;

— remove the cap without opening the cap;

- do not place the cork with the inner surface on a table or other objects;

- do not leave the bottle open;

- Store an opened bottle only in the refrigerator.

Opening the bottle and removing the required volume of the drug can be done with a sterile syringe by piercing the stopper. The drug from an opened bottle, subject to storage conditions, the above rules and the absence of turbidity, can be used throughout the expiration date.

Influence on the ability to drive vehicles and machinery. Not installed.

Release form. Solution for oral, local and external use in bottles of 20 ml or 100 ml. 4 or 8 bottles of 20 ml or 1 bottle of 100 ml in a cardboard pack with instructions for use.

Storage and transportation conditions. Storage in accordance with SP 3.3.2. at a temperature of 2 to 8 °C in a place protected from light and out of reach of children.

Transportation in accordance with SP 3.3.2. at temperatures from 2 to 8 °C, transportation at temperatures from 9 to 25 °C is allowed for no more than 1 month.

Best before date. Shelf life: 2 years. A drug that has expired cannot be used.

Vacation conditions. Available without a prescription.

Manufacturer/organization accepting claims:

FSUE NPO Microgen, Ministry of Health of Russia, Russia

115088, Moscow, st. 1st Dubrovskaya, 15, tel. , fax, e-mail: .

Russia, Nizhny Novgorod region, Nizhny Novgorod, st. Gruzinskaya, 44;

Russia, Perm region, Perm, st. Bratskaya, 177.

Source: http://xn——8kceunaflgjrqyoqfbei8dxl.xn--p1ai/%D0%91%D0%90%D0%9A%D0%A2%D0%95%D0%A0%D0%98%D0%9E%D0 %A4%D0%90%D0%93_%D0%A1%D0%A2%D0%90%D0%A4%D0%98%D0%9B%D0%9E%D0%9A%D0%9E%D0%9A %D0%9A%D0%9E%D0%92%D0%AB%D0%99_%D1%80%D0%B0%D1%81%D1%82%D0%B2%D0%BE%D1%80_%D0 %9C%D0%B8%D0%BA%D1%80%D0%BE%D0%B3%D0%B5%D0%BD

Bacteriophage staphylococcal liquid fl. 20 ml pack. 4 Microgen NPO Federal State Unitary Enterprise

Available only by prescription

Pharmacological groups

Pharmacological actions

*appearance of the product may differ from the product in this photo

Instructions for use

Compound

The solution for oral, local and external use contains:

  • Sterile filtrate of phagolysates of Staphylococcus strains.
  • Excipients

    Quinozol 0.0001 g/ml (preservative).

    The bottle contains 20 ml of solution. There are 4 bottles in the package.

    Application area

    • Русский
    • Diseases of the ear, nose, throat, respiratory tract and lungs:
      • Inflammation of the sinuses, middle ear.
      • Angina.
      • Pharyngitis.
      • Laryngitis.
      • Tracheitis.
      • Bronchitis.
      • Pneumonia .
      • Pleurisy.
    • Surgical infections:
      • Suppuration of wounds.
      • Burns.
      • Abscess.
      • Phlegmon.
      • Boils.
      • Carbuncles.
      • Hidradenitis.
      • Panaritiums.
      • Paraproctitis.
      • Mastitis.
      • Bursitis.
      • Osteomyelitis.
    • Urogenital infections:
      • Urethritis.
      • Cystitis.
      • Pyelonephritis.
      • Colpitis.
      • Endometritis.
      • Salpingo-oophoritis.
    • Enteral infections:
      • Gastroenteritis.
      • Cholecystitis.
    • Intestinal dysbiosis.
    • Generalized septic diseases.
    • Purulent-inflammatory diseases of newborns:
      • Omphalitis.
      • Pyoderma.
      • Conjunctivitis.
      • Gastroenterocolitis.
      • Sepsis.
    • Other diseases caused by staphylococci.
    • For preventive purposes:
      • Treatment of postoperative and newly infected wounds.
      • Prevention of nosocomial infections according to epidemic indications.

    An important condition for effective phage therapy is the preliminary determination of the phage sensitivity of the pathogen.

    general information

    The drug has the ability to specifically lyse Staphylococcus bacteria.

    Intended for the treatment and prevention of purulent-inflammatory and enteral diseases caused by bacteria of the genus Staphylococcus.

    An important condition for effective phage therapy is the preliminary determination of the phage sensitivity of the pathogen.

    Contraindications

    Side effect

    Interaction

    The use of bacteriophage does not exclude the use of other antibacterial drugs.

    Mode of application

    Before use, the vial with the bacteriophage must be shaken and inspected. The preparation must be transparent and free of sediment.

    Attention! If cloudy, do not use the drug!

    Due to the content of a nutrient medium in the drug, in which bacteria from the environment can develop, causing cloudiness of the drug, the following rules must be observed when opening the bottle:

    • Wash your hands thoroughly.
    • Treat the cap with an alcohol-containing solution.
    • Remove the cap without opening the cap.
    • Do not place the cork with the inner surface on a table or other objects.
    • Do not leave the bottle open.
    • Store an opened bottle only in the refrigerator.

    Opening the bottle and removing the required volume of the drug can be done with a sterile syringe by piercing the stopper.

    The drug from an opened bottle, subject to storage conditions, the above rules and the absence of turbidity, can be used throughout the shelf life.

    The drug is used for oral administration (oral), rectal administration, applications, irrigation, administration into wound cavities, vagina, uterus, nose, sinuses and drained cavities.

    Table Recommended dosage of the drug

    Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by taking the drug orally for 7-20 days (according to clinical indications).

    If chemical antiseptics were used to treat wounds before using the bacteriophage, the wound should be thoroughly washed with a sterile 0.9% sodium chloride solution.

    Depending on the source of infection, the bacteriophage is used:

    • Application in the form of irrigation, lotions and tamponing

    It is carried out in a volume of up to 200 ml, depending on the size of the affected area.

    In case of an abscess, after removing the purulent contents using a puncture, the drug is administered in an amount less than the volume of the removed pus.

    In case of osteomyelitis, after appropriate surgical treatment, the bacteriophage is infused into the wound.

    When administered into cavities (pleural, articular and other limited cavities), up to 100 ml, after which capillary drainage is left, through which the bacteriophage is administered for several days.

    The drug is taken orally.

    If the cavity of the bladder or renal pelvis is drained, the bacteriophage is injected through the cystostomy or nephrostomy 1-2 times a day, poured into the bladder and 5-7 ml into the renal pelvis.

    The drug is administered into the vaginal cavity, uterus in a dose of 6-10 ml once daily, for colpitis - 10 ml by irrigation or tamponing 2 times a day. Tampons are placed for 2 hours.

    The drug is administered in a dose of 2-10 ml 1-3 times a day. The bacteriophage is used for rinsing, washing, instilling, introducing moistened turundas (leaving them for 1 hour).

    The drug is taken orally 3 times a day 1 hour before meals. It is possible to combine double oral administration with a single rectal administration of a single age-specific dose of the bacteriophage in the form of an enema after bowel movement.

    The bacteriophage is used in the form of high enemas (through a gas outlet tube or catheter) 2-3 times a day in a dose of 5-10 ml.

    In the absence of vomiting and regurgitation, it is possible to use the drug by mouth. In this case, it is mixed with breast milk. A combination of rectal (in the form of high enemas) and oral (through the mouth) use of the drug is possible. The course of treatment is 5-15 days. In case of recurrent course of the disease, repeated courses of treatment are possible.

    In order to prevent sepsis and enterocolitis during intrauterine infection or the risk of nosocomial infection in newborns, the bacteriophage is used in the form of enemas 2 times a day for 5-7 days.

    The drug is used in the form of applications twice daily (a gauze pad is moistened with bacteriophage and applied to the umbilical wound or affected area of ​​skin).

    Source: http://www.smed.ru/pharmacy/bakteriofag-stafilokokkoviy-zhidkiy-fl-20-ml-up-4-mikrogen-npo-fgup