Antibiotic lincomycin

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Antibiotic lincomycin

Lincomycin is a natural antibiotic and belongs to the group of lincosamides. Also included in the same group is its semisynthetic analogue, clindamycin. In small doses, this drug prevents the proliferation of bacteria, and in higher concentrations it destroys them.

Table of contents:

Lincomycin is effective against bacteria resistant to erythromycin, tetracyclines and streptomycin, and is useless against viruses, fungi and protozoa.

Indications for use

Lincomycin is prescribed for infectious and inflammatory diseases caused by microorganisms sensitive to this antibiotic. These include inflammation of the middle ear, otitis media, infections of bones and joints, pneumonia, skin infections, furunculosis, purulent inflammation of wounds and burns, and erysipelas.

This antibiotic is widely used in dentistry, since it affects most pathogens in the oral cavity and accumulates in bone tissue, creating the concentration necessary for treatment.

Lincomycin is used in ampoules for intramuscular and intravenous injections, as well as in tablets and as an ointment for external inflammation.

Side effects and contraindications

The use of lincomycin can cause disturbances in the gastrointestinal tract - nausea, diarrhea, vomiting, abdominal pain, mouth ulcers, and with long-term use - thrush and blood disorders. Allergic reactions are also possible in the form of urticaria, skin irritations, Quincke's edema (rapidly developing swelling of various parts of the face and mucous membranes), anaphylactic shock.

Lincomycin is contraindicated in case of individual intolerance, liver and kidney diseases, pregnancy and while breastfeeding. Also, it should not be prescribed to children in the first month of life.

It is used to a limited extent for fungal diseases of the skin, mucous membranes of the mouth, and genitals. Among medications, this antibiotic is not compatible with calcium gluconate, magnesium sulfate, heparin, theophylline, ampicillin and barbiturates.

Most often, lincomycin is used in hospitals, which is why the percentage of side effects and complications caused by its use is high. Release forms and dosages

Lincomycin is available in tablets, ampoules and ointment form.

  1. In ampoules for intramuscular and intravenous injections. For intramuscular injections, a single dose is 0.6 g, 1-2 times a day. In this case, the needle should be inserted as deeply as possible, otherwise there is a risk of thrombosis and tissue death (necrosis). When administered intravenously, the drug is diluted with saline or glucose at the rate of 0.6 g per 300 ml, and administered through a dropper 2-3 times a day. Lincomycin in one syringe or dropper is incompatible with novobiocin or kanamycin. The maximum daily dose of the drug for an adult is 1.8 g, but in case of severe infection the dose is increased to 2.4 g. For children, dosages of mg per kilogram of weight are indicated, at intervals of at least 8 hours. With rapid intravenous administration, dizziness, weakness, and decreased blood pressure may occur.
  2. Tablets are available in 250 and 500 mg. Capsules must not be divided or opened. The drug should be taken 1 hour before or 2 hours after meals, washed down with plenty of water. For adults, the drug is prescribed one tablet (500 mg) 3 times a day for moderate infections, and 4 times a day for severe infections. Children under 14 years of age can take lincomycin at the rate of 30 mg per kilogram of body weight per day, divided into 2-3 doses.
  3. Lincomycin-AKOS is a 2% ointment for external use. Available in aluminum tubes of 10 and 15 g. The ointment is applied to the damaged area 2-3 times a day in a thin layer.

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Lincomycin

Instructions for use:

Latin name: Lincomycin

ATX code: J01FF02

Active ingredient: Lincomycin (Lincomycin)

Analogs: Lincomycin hydrochloride, Lincocin Clindamycin, Dalatsin C, Clindamycin-Norton

Manufacturer: Sintez OJSC, Russia

Description current as of: 09.28.17

Price in online pharmacies:

Lincomycin is a broad-spectrum antibiotic. It is used to treat diseases caused by the activity of most gram-positive bacteria.

Active substance

Release form and composition

Lincomycin is available in several dosage forms: as an injection solution for intravenous and intramuscular administration (5, 10 or 100 ampoules per package); in the form of capsules (10, 20 or 360 capsules per package); in the form of a 2% ointment intended for external use (10 or 15 g of ointment in a tube).

Indications for use

Lincomycin is prescribed in the following cases:

  • For the treatment of infectious diseases of the ENT organs and respiratory tract caused by antibiotic-sensitive microorganisms (including otitis media, bronchitis, pharyngitis, tracheitis, sinusitis, pneumonia, lung abscess, etc.).
  • For infectious diseases of bones and joints caused by the activity of microorganisms sensitive to the drug.
  • For the treatment of infectious diseases of the skin and soft tissues caused by microorganisms sensitive to Linomycin (including infected purulent wounds, furunculosis, abscess, felon, erysipelas and mastitis).

In dentistry, Lincomycin is used for various infections of the maxillofacial apparatus. The main advantage of this drug compared to other antibiotics is its ability to be deposited in teeth and bone tissue.

Often in dentistry, the drug is used in combination with lidocaine to eliminate purulent processes in periodontitis, periodontitis and gingivitis. Lincomycin is also effective in dentistry when it is necessary to avoid secondary infections on the surface of the wound after tooth extraction. Since there are no direct instructions in the instructions about the need to use the drug in dentistry, the question of the possibility of its use should be discussed with your doctor.

Contraindications

Lincomycin should not be prescribed if there is hypersensitivity to its active substance, or if the patient has severe impairment of liver and kidney function.

The use of Lincomycin is contraindicated in pregnant and lactating women due to the ability of the drug to penetrate the placental barrier.

Instructions for use Lincomycin (method and dosage)

Lincomycin capsules are prescribed 500 mg 3-4 times a day. As a rule, the duration of treatment is 1-2 weeks, and for osteomyelitis – 3 weeks or more. Capsules should be taken several hours before meals with water.

Lincomycin hydrochloride is prescribed intramuscularly at 600 mg 1-2 times a day. The drug is administered intravenously at a dose of 600 mg several times a day.

For children, Lincomycin capsules are prescribed in a daily dose equal to mg per kilogram of weight. If necessary, every 8-12 hours the child is administered intravenous lincomycin hydrochloride at the rate of mg per kilogram of body weight.

Lincomycin ointment is applied in a thin layer to damaged areas of the skin several times a day. The ointment should be used with caution for fungal skin infections and dermatomycosis.

Side effects

The use of the drug Lincomycin may cause the following side effects:

  • From the hematopoietic system - neutropenia, reversible leukopenia, thrombocytopenia.
  • From the digestive system - stomatitis, epigastric pain, nausea, glossitis, diarrhea, vomiting; with long-term use of high doses of the drug, the development of pseudomembranous colitis is possible.
  • Allergic reactions - exfoliative dermatitis, Quincke's edema, urticaria, anaphylactic shock.
  • With rapid intravenous administration - general weakness, phlebitis, dizziness, decreased blood pressure, relaxation of skeletal muscles.

Overdose

Analogs

Lincomycin hydrochloride, Lincocin Clindamycin, Dalatsin C, Clindamycin-Norton.

pharmachologic effect

Lincomycin is an antimicrobial drug that belongs to the lincosamide group of antibiotics. It has a pronounced bacteriostatic effect, and with increasing dosage it has a bactericidal effect on the body. The mechanism of action of this drug is to inhibit the process of protein synthesis in microbial cells.

Lincomycin hydrochloride is active primarily against aerobic gram-positive bacteria: Corynebacterium diphtheriae, Streptococcus spp. (except Enterococcus faecalis), Staphylococcus spp. (including strains producing penicillinase) and anaerobic bacteria (Bacteroides spp., Clostridium spp.).

Almost all gram-negative bacteria, protozoa, fungi, viruses and Enterococcus faecalis are resistant to this antibiotic.

special instructions

If renal and/or liver function is impaired, it is necessary to reduce the single dose of lincomycin by 1/3-1/2 and increase the interval between doses. With prolonged use, systematic monitoring of liver and kidney functions is required.

If pseudomembranous colitis develops, the drug should be discontinued and bacitracin or vancomycin should be prescribed.

During pregnancy and breastfeeding

Lincomycin crosses the placental barrier and is excreted in breast milk. The use of the drug during pregnancy is contraindicated.

If it is necessary to prescribe during lactation, the issue of stopping breastfeeding must be resolved.

In childhood

Children aged 1 month to 14 years intramg/kg/day; Injected intravenously into dosemg/kg every 8-12 hours.

In old age

For impaired renal function

Contraindicated in cases of severe renal impairment.

If renal function is impaired, it is recommended to reduce the single dose of lincomycin by 1/3 - 1/2 and increase the interval between doses.

With prolonged use, systematic monitoring of renal function is necessary.

For liver dysfunction

Contraindicated in cases of severe functional liver disorders.

If liver function is impaired, it is recommended to reduce the single dose of lincomycin by 1/3 - 1/2 and increase the interval between doses.

With long-term use, systematic monitoring of liver function is necessary.

Drug interactions

The use of Lincomycin in combination with penicillins, cephalosporins, chloramphenicol or erythromycin can lead to antagonism of the antimicrobial action, and when treated together with aminoglycosides, to a synergistic action.

Lincomycin should be used with caution concomitantly with peripherally acting muscle relaxants due to the possibility of increased neuromuscular blockade, which in some cases leads to apnea.

Antidiarrheal drugs reduce the bactericidal effect of the antibiotic.

When using Lincomycin, it is necessary to take into account that this drug is incompatible with barbiturates, kanamycin, ampicillin, novobiocin, heparin, calcium gluconate, theophylline and magnesium sulfate.

Conditions for dispensing from pharmacies

Storage conditions and periods

Store in a dry place protected from the sun at an air temperature of +15. +25 °С. The shelf life of capsules is 4 years, and the ointment and injection solution is 3 years.

Price in pharmacies

The price of Lincomycin starts from 10 rubles. for 1 package.

The description posted on this page is a simplified version of the official version of the annotation for the drug. The information is provided for informational purposes only and does not constitute a guide for self-medication. Before using the medicine, you must consult a specialist and read the instructions approved by the manufacturer.

Lincomycin capsules 250 mg 20 pcs.

Lincomycin capsules 250 mg 20 pcs.

Lincomycin 250 mg No. 20 caps

Lincomycin capsules 250 mg n20

Lincomycin 250 mg No. 20 capsules

When using materials from the site, the active reference is obligatory.

The information presented on our website should not be used for self-diagnosis and treatment and cannot serve as a substitute for consultation with a doctor. We warn you about the presence of contraindications. Specialist consultation is required.

Source: http://dolgojit.net/linkomitcin.php

Lincomycin - instructions for use + reviews and use in dentistry

The drug Lincomycin from the group of lincosamide antibiotics is characterized by high bacteriostatic activity against gram-positive pathogenic microflora. It is used to treat purulent infections of various locations and is available in several dosage forms. Resistance to it in pathogens develops quite slowly, which allows the drug to be successfully used in various fields of medicine for a long time.

Lincomycin - instructions for use of tablets

The scope of antimicrobial activity includes mainly gram-positive microorganisms. Gram-negative microflora (as well as fungi, protozoa and viruses). Therefore, it is often prescribed as part of complex therapy with aminogycosides, with which it interacts synergistically. It exhibits cross-resistance with another drug of its group (clindamycin). The antibiotic lincomycin is used especially successfully in dentistry.

Acid-stable, but bioavailability after oral administration is low - about 30%. Distributed throughout almost the entire body, with the exception of the cerebrospinal fluid. It is excreted in bile and urine, both unchanged and in the form of metabolites. The latter property increases the risk of liver and kidney dysfunction, requiring constant medical monitoring of the patient’s condition.

The most convenient and practical form of antibiotic therapy is oral administration. However, the use of capsules (sometimes erroneously called tablets) in this case requires strict adherence to the instructions due to the pharmacokinetics of the antibiotic. Low bioavailability (no more than 30-40% of the active substance is absorbed in the digestive tract) does not allow taking capsules on a full stomach. The presence of food inhibits the absorption process and, as a result, no more than 5% of lincomycin is absorbed. The optimal dosage regimen in this case is one hour before meals or two hours after.

Photo of Lincomycin in capsules

Release form and composition

The active ingredient is lincomycin, an enzyme produced by the bacterium Streptomyces lincolniensis. This compound stops the growth and development of a pathogenic cell (that is, it acts bacteriostatically) due to the mechanism of protein synthesis inhibition. As a result, irreversible structural changes are formed, and when the dose is increased, the bactericidal properties of the drug appear, and the pathogenic bacterium dies.

The initial raw material for the production of medicines is a white crystalline bitter powder, easily soluble in water, but poorly soluble in alcohol. Pharmacy chains offer the following forms of release of Lincomycin:

  • Tablets (more precisely, white-yellow gelatin capsules) containing 250 mg of active ingredient each. The package contains 6, 0 or 20 pieces.
  • Ampoules with an injection or infusion solution, 1 ml of which contains 300 mg of antibiotic. Volume – 1 or 2 ml, in a cardboard pack – 10 pieces.
  • Two percent ointment for topical use in aluminum tubes of 10 or 15 grams.

In addition to the main active component, each of the listed dosage forms also includes additional ingredients. For capsules, these are sucrose, potato starch and gelatin shell components. For ampoules - water for injection, disodium edetate and sodium hydroxide solution. The ointment contains paraffin wax, petroleum jelly, potato starch and zinc oxide.

Lincomycin capsules: what helps?

Since the drug has a systemic effect on the body, it is taken in all the cases described above:

  • respiratory tract infections caused by gram-positive pathogens;
  • purulent lesions of joints, muscles, bones and skin (arthritis, osteomyelitis, wound infection, erysipelas, pyoderma and others).
  • ENT diseases;
  • endocarditis, empyema, sepsis;
  • development of postoperative complications.

Skin infections are usually treated comprehensively: in addition to capsules, it is recommended to topically use an ointment containing lincomycin hydrochloride.

Prescription for lincomycin in Latin

Rp.: Lincomycinum 0.5

S. 1 tablet 3 times a day.

Indications for use of Lincomycin and contraindications

Specific antimicrobial action and high efficiency make it possible to successfully treat diseases such as:

  • Local and generalized inflammatory processes in the body (endocarditis, pleural empyema, lung abscess, wound infection, postoperative complications and sepsis).
  • Lesions of the skin and subcutaneous tissue, accompanied by suppuration - erysipelas, pyoderma, phlegmon and furunculosis.
  • Purulent infections of the musculoskeletal system (for example, osteomyelitis, arthritis).
  • Acute and aggravated chronic diseases of all parts of the respiratory system. From ENT diseases (Lincomycin is especially effective for sinusitis and otitis media) to bronchitis and pneumonia.

Absolute contraindications for use are pregnancy (the antibiotic easily crosses the placental barrier), lactation, hypersensitivity to lincosamides and severe dysfunction of organs such as the liver and kidneys. Moderate deficiency in the latter case requires constant monitoring of the patient's condition and dose adjustment downward. Breastfeeding women should temporarily switch to artificial feeding, expressing milk in order to maintain lactation.

Lincomycin and alcohol

Combining any medications with alcoholic beverages is undesirable. Antibiotics, as a rule, create additional stress on the liver, so it is not advisable to increase it. Restoring hepatocytes is a long and expensive undertaking, and in some cases, toxic antibacterial drugs in combination with alcohol can lead to irreversible consequences for the liver.

Ethanol also accelerates the process of removing lincosamides from the body, reducing the therapeutic effect. In addition, the snack accompanying the feast interferes with the absorption of the medicine.

Side effects of Lincomycin and drug compatibility

Antibiotic therapy with this drug can cause dyspeptic disorders such as nausea, vomiting, and epigastric pain. The development of pseudomembranous colitis (characterized by severe diarrhea), allergic reactions, reversible hematopoietic disorders, glossitis, stomatitis, candidiasis of the genitals and digestive tract is possible. Topical application is fraught with skin rashes, and intravenous administration - phlebitis or decreased blood pressure and muscle weakness.

It is extremely undesirable to combine lincomycin and alcohol, since the latter accelerates the removal of the drug from the body and creates additional stress on liver cells. Combination antibiotic therapy is possible only in combination with aminoglycosides that are active against gram-negative pathogenic microflora (as a result, the drugs act synergistically).

Penicillins and antibiotics of other groups are antagonists of Lincomycin. Any antidiarrheal drugs reduce the effectiveness of the antibiotic. Combined use with muscle relaxants, inhalation anesthesia and opiate analgesics is undesirable, as the risk of blocking neuromuscular transmission and, accordingly, respiratory arrest increases. The dosage of theophylline taken during treatment with lincosamides also requires adjustment.

Dosage and application regimen

Due to the peculiarities of absorption and excretion, the capsule form of the drug must be taken strictly on an empty stomach, observing a two-hour pause before eating. The recommended daily dose for an adult is 1.5 grams, divided into 3 doses. Children, starting from the age of three, can be prescribed medicine based on the formula “30 mg per kg of body weight per day” (in case of severe disease, the dosage of lincomycin can be doubled).

The course duration is usually 1-2 weeks, but antibiotic therapy for osteomyelitis may require 3 months of use. Patients suffering from kidney and/or liver dysfunction should receive less medication. If the drug is used repeatedly for a short period of time, monitoring of its condition and control of tests is mandatory.

Lincomycin hydrochloride injections and ointment: instructions for use

The drug in the form of an ointment is used topically for purulent lesions of the epidermis. Indications for use are phlegmon, furunculosis, erysipelas and pyoderma. It can provoke the growth of fungal microflora, so people suffering from dermatomycosis should use it with caution and only with the permission of a dermatologist. Apply three times a day to the affected areas.

Photo of Lincomycin in injections

A solution of lincomycin in ampoules is used in the same cases as tablets and ointment, providing a systemic effect. Both intramuscularly and intravenously, it is recommended to administer 1.8 grams of the active substance per day to adults, and from 10 to 20 mg per kilogram of weight to children. This is done at intervals of 8 hours, while intravenous use requires strict adherence to the instructions. 2 ml of the drug are diluted in 0.25 liters of isotonic solution and administered dropwise at a rate of no more than 80 drops per second. A faster release of the drug into the blood provokes muscle weakness and a decrease in blood pressure.

Lincomycin in dentistry

In this area of ​​medicine, it is one of the most prescribed drugs due to its ability to accumulate in bone tissue. It is used for antibiotic therapy of gingivitis, stomatitis, periodontitis and other inflammatory processes accompanied by the formation of pus. It is usually prescribed in the form of an ointment (applied to the affected area three times a day) or capsules. However, in case of particularly severe periodontal pathologies, injections (including into the gums) can be used.

When toothache occurs due to inflammation, it relieves symptoms due to its antimicrobial effect. Can be used for injection in combination with the analgesic lidocaine. It is of great preventive value after tooth extraction, as it helps prevent the development of wound infection and other complications.

Lincomycin during pregnancy and breastfeeding

The drug is contraindicated in pregnant women, unless its use is justified for health reasons. In other cases, it is recommended to replace lincomycin with another antibiotic.

While taking lincomycin, breastfeeding is recommended to be temporarily suspended.

Analogs

In pharmacies, lincomycin is sold under the names:

Lincomycin: reviews of tablets and injections

Most patients respond positively to the drug. First of all, its relatively low cost and mild side effects are noted. However, frequent repeated courses, judging by reviews, reduce the therapeutic effectiveness of the antibiotic and cause negative effects on the liver and kidneys.

However, proper use in full accordance with the intended purpose helps to get rid of many serious diseases. For example, most patients noted the exceptional effectiveness of the drug Lincomycin for sinusitis, purulent skin lesions and inflammation of the respiratory tract. Thus, consulting a doctor and following his recommendations will make the treatment effective and help avoid negative consequences.

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Lincomycin

Instructions for use:

Prices in online pharmacies:

Lincomycin is an antibiotic used to treat various diseases caused by most gram-positive bacteria.

pharmachologic effect

Lincomycin, being an antibiotic, is active in therapeutic doses against:

  • Streptococcus spp., including Streptococcus pneumoniae;
  • Bacteroides spp.;
  • Mycoplasma spp.;
  • Staphylococcus spp., including strains that produce penicillinase;
  • Corynebacterium diphtheriae;
  • Clostridium spp.

According to the instructions, Lincomycin does not affect most gram-negative bacteria, viruses, Enterococcus faecalis, fungi and protozoa.

Lincomycin slowly develops resistance, is rapidly distributed in body tissues and fluids, including bone tissue, and penetrates the placental barrier.

When using Lincomycin, it should be taken into account that there is cross-resistance between clindamycin and the drug.

Release form

Lincomycin is available as:

  • White Lincomycin capsules with a yellow cap, containing 250 mg of the active substance - lincomycin hydrochloride, in the form of white powder, 10, 20, 360 pieces per package;
  • 2% ointment for external use, 10 or 15 g in tubes;
  • A solution for intramuscular and intravenous administration of Lincomycin hydrochloride, containing 300 or 600 mg of active substance per ampoule, 5, 10, 100 ampoules per package.

Indications for use of Lincomycin

Lincomycin is used according to the instructions for the treatment of severe infectious and inflammatory diseases, including:

Lincomycin ointment is used topically in the treatment of purulent-inflammatory skin diseases.

In dentistry, Lincomycin is used to treat various infections of the maxillofacial system. Its main advantage over other antibiotics is its ability to be deposited in bone tissue and teeth.

Quite often, Lincomycin in dentistry is used together with lidocaine to eliminate purulent processes in gingivitis, periodontitis or periodontitis.

Lincomycin is also used to avoid secondary infection on the wound surface in the socket area after tooth extraction. There is no clear opinion regarding the advisability of using the drug in these cases.

Also, there are no direct instructions in the instructions for the use of Lincomycin in dentistry, so the question of its use must be discussed with a doctor.

Contraindications to the use of Lincomycin

According to the description, Lincomycin is contraindicated in cases of sensitivity to the active ingredients of the drug (clindamycin or lincomycin), as well as in cases of severe impairment of kidney and liver function.

The use of Lincomycin is contraindicated during lactation and pregnancy due to the penetration of the drug through the placental barrier.

Instructions for use of Lincomycin

When taking Lincomycin in capsules, use 500 mg 3-4 times a day. Typically, the duration of treatment is from one to two weeks, with osteomyelitis - up to three weeks or more. Lincomycin capsules are taken several hours before meals with a small amount of liquid.

Lincomycin is used intravenously according to the instructions up to 2 times a day, 600 mg.

Lincomycin hydrochloride is administered intravenously by drip, 600 mg several times a day.

Children are prescribed Lincomycin capsules in a daily dose calculated as mg per 1 kg of body weight.

If necessary, Lincomycin hydrochloride is administered intravenously every 8-12 hours at the rate of mg per 1 kg of body weight.

When applied topically as an ointment, Lincomycin is applied in a thin layer to the affected areas of the skin several times a day. The ointment is used with caution for dermatomycosis and fungal skin diseases.

When using Lincomycin simultaneously with cephalosporins, penicillins, erythromycin or chloramphenicol, antagonism of the antimicrobial action may occur, and when used simultaneously with aminoglycosides, synergism of action may occur.

Lincomycin should be used with caution simultaneously with peripherally acting muscle relaxants and for inhalation anesthesia due to the possibility of increased neuromuscular blockade, sometimes leading to the development of apnea.

Antidiarrheal drugs lead to a decrease in the bactericidal effect of Lincomycin.

When using Lincomycin, it should be taken into account that the drug is pharmaceutically incompatible with:

Side effects of Lincomycin

According to instructions and reviews, Lincomycin may cause the following side effects:

  • Glossitis;
  • Epigastric pain;
  • Reversible leukopenia;
  • Stomatitis;
  • Exfoliative dermatitis;
  • Diarrhea;
  • Anaphylactic shock;
  • Increased levels of liver transaminases and bilirubin in blood plasma;
  • Nausea;
  • Candidiasis;
  • Neutropenia;
  • Vomiting;
  • Thrombocytopenia;
  • Urticaria;
  • Quincke's edema.

With long-term use of Lincomycin in high doses, the development of pseudomembranous colitis is possible.

With intravenous use, phlebitis may develop; with rapid intravenous administration, general weakness, dizziness, relaxation of skeletal muscles and a decrease in blood pressure may be observed.

Storage conditions

Lincomycin is available with a doctor's prescription. According to the description, the shelf life of Lincomycin capsules is 4 years, the solution for injection and ointment is 3 years.

Lincomycin caps. 250 mg No. 20

Lincomycin caps. 250 mg No. 20

Lincomycin capsules 250 mg 20 pcs.

Lincomycin capsules 250 mg 20 pcs.

Lincomycin ointment 2% 15g

Lincomycin 250 mg No. 20 caps

Lincomycin capsules 250 mg n20

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Lincomycin - instructions for use

For use in dentistry, in the treatment of sinusitis, tracheitis, and other diseases of the ENT organs, Lincomycin is used - instructions for use of the medication describe the dosage regimen and indications. The drug for antibacterial therapy eliminates inflammatory processes, abscesses, and kills microorganisms that cause diseases. Read its instructions.

The drug Lincomycin

According to the pharmacological classification, Lincomycin is an antibacterial agent. This allows it to kill anaerobic bacteria that cause disease and impair the healing process. The antibiotic Lincomycin belongs to the lincosamide class and is available in several forms. The active ingredient in it is lincomycin hydrochloride.

Composition and release form

The drug can be purchased in the format of capsules (tablets), ointment (cream) and solution for injection. Detailed composition:

Capsules with white body and yellow cap, white powder inside

Transparent colorless liquid with a characteristic faint odor

White-yellowish ointment

Concentration of lincomycin hydrochloride

Excipients of the composition

Calcium stearate, colloidal silica, microcrystalline cellulose, gelatin, titanium dioxide

Disodium edetate, sodium hydroxide solution, water

Zinc oxide, paraffin, potato starch, petroleum jelly

6, 10 or 20 capsules

1 or 2 ml per ampoule, 5 or 10 ampoules per cardboard box with ampoule scarifier

10 or 15 g in aluminum tubes

Pharmacodynamics and pharmacokinetics

In therapeutic doses, the antibiotic acts bacteriostatically; in higher doses it has a bactericidal effect. Inhibits the protein synthesis of bacteria in the cell, is active against staphylococci, streptococci, clostridium bacteria, and mycoplasmas. The overwhelming majority of gram-negative bacteria, fungi, viruses and protozoan microorganisms are resistant to it.

When taken orally, it is absorbed from the stomach and intestinal tract by 35%; food intake slows down the rate and extent of absorption. The active substance is widely distributed in bone tissue and fluids and penetrates the placental barrier. Metabolism occurs in the liver, the half-life is five hours. It is excreted from the body by the kidneys and intestines with urine, bile and feces.

What is Lincomycin for?

Instructions for use indicate the following indications for use of the drug in patients:

  • severe diseases caused by microorganisms sensitive to the drug;
  • sepsis, osteomyelitis, septic endocarditis;
  • respiratory diseases: diphtheria, tonsillitis, bronchitis, tracheitis, laryngitis;
  • inflammation of the kneecap;
  • pneumonia, lung abscess, wound infections;
  • infections caused by strains of staphylococcus or other gram-positive bacteria resistant to penicillin;
  • pyoderma, furunculosis, erysipelas for ointment.

Lincomycin in dentistry

Dentists call Lincomycin one of the best remedies for the treatment of inflammatory and purulent processes, because it quickly stops the destructive process in teeth and helps tissues heal. The active substance accumulates in the tissues of teeth and gums. Indications for use in dentistry are the following diseases:

  • periodontitis;
  • ulcerative gingivitis;
  • inflammation of periodontal tissues;
  • purulent infections, abscesses;
  • suppuration in periodontal pockets;
  • stomatitis;
  • osteomyelitis;
  • periodontitis.

A special form of Lincomycin, Dental, has been released especially for dentists. It is a film impregnated with medicine, which is glued to parts of the oral cavity for an antibacterial effect. It lasts a long time and can be used by patients independently. Lincomycin injections are used in the treatment of restoration of destroyed bone tissue, ointment to relieve bleeding and inflammation of the gums (at night after brushing your teeth). The ointment can also be used to treat herpes and lubricate tooth areas while wearing braces.

Directions for use and dosage

According to the instructions, the method of use and dosage depend on the chosen format of the medicine and the severity of the disease. The medication is prescribed by a doctor, and the course and regimen are prescribed. Tablet dosage regimen: 500 mg three times a day. The dosage can be increased to 500 mg in four doses, the course lasts 1-2 weeks. The dose is adjusted depending on age and the presence of renal or hepatic impairment.

Lincomycin in ampoules

According to the instructions, the ampoule solution is prescribed to children from one month old; younger than this age, the drug is not used. The drug is administered intravenously in the following dosage:

  • under the age of 14 years – mg/kg every 8-12 hours;
  • adults - intravenous Lincomycin 600 mg in 250 ml of physiological solution of sodium chloride or glucose, frequency - 2-3 times a day; for severe infections, injections of Lincomycin 600 mg 1-2 times a day are given intramuscularly.

Pills

Tablets are intended for oral administration. They are consumed orally 1-2 hours before meals or 2-3 hours after. It is necessary to take Lincomycin capsules with plenty of clean water. Frequency of application – 2-3 times/day with an interval of 8-12 hours. Instructions for use contain the following dosage recommendations:

  • children aged 3-14 years – mg/kg/day;
  • adults – single dose 500 mg, maximum daily dose is 1-1.5 g, frequency 3-4 times/day;
  • angina is treated for 10 days; when treating the disease, you can combine taking pills and intravenous administration of a solution to eliminate the effects of microorganisms on the heart and lungs.

According to the instructions, Lincomycin ointment is applied externally. It is applied directly to the affected area in a thin layer for skin diseases, repeating the procedure two or three times a day. This form of medication can be used with caution in children older than one month due to the increased risk of allergic dermatitis; for adults, use for the treatment of skin infections is carried out as usual.

special instructions

The instructions for use indicate special instructions that must be followed when using the drug:

  • for patients suffering from impaired liver and kidney function, the single dose is reduced by half or by a third, while the interval between use is increased;
  • with the development of pseudomembranous colitis, Lincomycin is canceled and replaced with Vancomycin or Bacitracin;
  • Medication therapy is carried out with caution if patients have allergic reactions, bronchial asthma, colitis, or a history of gastrointestinal diseases;
  • not used to treat meningitis.

Lincomycin during pregnancy

The instructions say that Lincomycin crosses the placental barrier and is found in breast milk, so its use during pregnancy and breastfeeding is strictly prohibited (it can cause mastitis). During lactation, if the mother needs to undergo therapy with Lincomycin, breastfeeding is canceled for the entire period of therapy plus the time needed to remove the remaining active substance from the body.

Drug interactions

The drug may have an effect on other medications. Such interactions are described in the instructions for use:

  • penicillins, cephalosporins, chloramphenicol, erythromycin can cause antimicrobial antagonism;
  • aminoglycosides lead to synergistic action;
  • agents for inhalation anesthesia and anesthesia, muscle relaxants enhance neuromuscular blockade until apnea develops;
  • antidiarrheal drugs reduce effectiveness;
  • the medication is incompatible with ampicillin, barbiturates, theophylline, calcium gluconate, heparin, magnesium sulfate;
  • Kanamycin and novobiocin cannot be combined in one injection syringe or dropper.

Alcohol compatibility

The drug is incompatible with ethanol; alcohol slows down the absorption of the drug in the gastrointestinal tract, has a negative effect on the liver, increasing the half-life of the drug and increasing the load on the organ. Alcohol-containing drinks or medications when combined with Lincomycin reduce the effectiveness of the medication and increase the risk of negative side effects.

Side effects

According to the instructions, the drug can cause the following side effects that will cause discomfort to the patient:

  • nausea, diarrhea, stomatitis, glossitis;
  • reversible leukopenia (decreased white blood cells);
  • urticaria, allergic reactions, dermatitis;
  • candidiasis, phlebitis;
  • intestinal dysbiosis, which can lead to erosive damage to its walls;
  • impaired coordination of movements;
  • decreased blood pressure, dizziness, weakness, relaxation of skeletal muscles.

Overdose

According to reviews and instructions for use, no consequences were observed after an overdose of the drug. If you take the medicine orally for a long period of time in large doses, you may develop pseudomembranous colitis and candidiasis infection. If signs of these diseases appear, treatment should be stopped and consult a doctor. Hemodialysis and peritoneal dialysis are not effective in removing the active substance from the blood.

Contraindications

The instructions indicate the following contraindications, in the presence of which the use of the drug is strictly prohibited due to unwanted side effects and harm to health:

  • severe renal and liver dysfunction;
  • pregnancy, breastfeeding;
  • hypersensitivity to components, clindamycin;
  • children up to a month for solution and ointment, up to three years for tablets, up to five years for dental use;
  • fungal diseases (the drug is not effective against fungal pathogens), fungal or viral tonsillitis.

Terms of sale and storage

All types of medicine are sold in pharmacies with a prescription. The drug is stored in a dry, dark place away from children at a temperature of 0 degrees. The shelf life for the ointment is two years, for all other forms of release - four.

Analogs

Based on the active substance of the composition and the therapeutic effect provided, the following analogs of the drug are distinguished, produced in the form of tablets, solution and ointment by domestic and foreign pharmaceutical companies:

The cost of the drug depends on what form of medicine the doctor prescribed to the patient, the number of ampoules or tablets in the package and the trade markup. Approximate prices in Moscow are shown in the table:

Pharmacy prices, rubles

Ampoules 10 pcs. 1 ml each

Ampoules 5 pcs. 2 ml each

Video

Reviews

Vitaly, 34 years old

Last year, the doctor prescribed me Lincomycin for a sore throat - I had a severe course of the disease, complicated by purulent discharge on the tonsils. The antibiotic helped almost instantly, relieved inflammation and pain when swallowing, plus prevented the disease from affecting serious organs. According to the reviews I read, this is the most effective drug for treating sore throat.

I caught a cold after being caught in the rain and treated myself at home, but the cough did not go away and I developed chest pains. I got scared and went to the doctor. He diagnosed bronchitis and prescribed medicine. It became Lincomycin for bronchitis in capsules. I drank them strictly according to the instructions, took them every day, and within a week I managed to reduce the symptoms and alleviate the condition.

The child was diagnosed with stomatitis, which he caught from unwashed hands. The dentist recommended a special drug, Dental Lincomycin, to heal the ulcers. I've never heard of this, but the doctor told me that it is only for dental problems. It’s easy to use – just stick a film on the sores and wear them until they fall off.

I caught a cold and ended up in the hospital with pneumonia. It was painful and unpleasant, but the doctors quickly got me back on my feet, putting me on drips with the antibiotic Lincomycin. After the danger was relieved, I was discharged home and was also prescribed capsules of the drug. I drank them for a week, after which I restored my immunity and lung health.

The information presented on the site is for informational purposes only. The site materials do not encourage self-treatment. Only a qualified doctor can make a diagnosis and make recommendations for treatment based on the individual characteristics of a particular patient.

Source: http://vrachmedik.ru/656-linkomicin-instrukciya-po-primeneniyu.html

Lincomycin: instructions for use

Lincomycin is a drug in the form of capsules and injections that has an antibacterial effect against bacteria sensitive to it, used for the treatment of infectious and inflammatory diseases of the respiratory, musculoskeletal, and ENT systems.

It belongs to the lincosamide group of antibiotics. The mechanism of action is the ability to suppress the formation of bacterial proteins by binding to the ribosomal subunit, disrupting the formation of peptide bonds.

The effectiveness of the drug is manifested in relation to:

  • gram-positive bacteria: staphylococci, streptococci, pneumococci, corynebacterium diphtheria;
  • spore-forming anaerobes: clostridia;
  • gram-negative anaerobes: bacteroides, mycoplasma.

The antibiotic actively affects bacteria that are resistant to other antibacterial agents. Enterococci, gram-negative bacteria, fungi, viruses, and protozoa are not sensitive to it.

This lincosamide drug is less effective against spore-forming anaerobes, Neisseria, and corynebacteria than erythromycin.

Resistance to its antibiotic action develops slowly. Cross-resistance occurs with clindamycin. When using therapeutic dosages, the drug acts bacteriostatically; increasing the dosage above the recommended one leads to the development of a bactericidal effect.

Lincomycin is a prescription drug and can only be used as prescribed by a doctor if indicated.

Release form and composition

The dosage form is presented in capsules of 250 mg and ampoules of 1 ml with a dosage of 300 mg/ml.

Indications for use

Indications for the use of an antibacterial agent are infections with microorganisms that are sensitive to its effects:

  • with an infectious lesion of the respiratory system (inflammation or abscess of the lungs, pleural empyema);
  • for diseases of the ENT organs (otitis media);
  • in case of infection of the osteoarticular system (osteomyelitis, bacterial arthritis);
  • when the skin and soft tissues are infected (pyoderma, boils, phlegmon, erysipelas, infected wound).

Contraindications

  • hypersensitivity to the components of the drug;
  • severe liver or kidney dysfunction;
  • the child is under 1 month old.

Caution must be exercised with mycosis of the skin, mucous membranes of the oral cavity or vagina, as well as with myasthenia gravis.

Directions for use and dosage

Daily dosages for oral administration, divided into 2-3 doses, are:

  • adults – 1.5–2 g;
  • children from 1 month to 14 years – 30–60 mg/kg;

Daily dosages in injection form, which are carried out in 2-3 administrations, are:

  • adults - 1.8 g;
  • children from 1 month to 14 years – 10–20 mg/kg body weight.

The ointment is applied in a thin layer to the lesions up to 3 times a day.

Side effects

  • digestive tract: nausea, vomiting, diarrhea, pain in the abdominal region, inflammation of the tongue and oral cavity, increased bilirubin and liver transaminases in the blood, candidiasis of the digestive system, pseudomembranous colitis, diarrhea caused by taking an antibiotic;
  • hematopoietic system: decrease in the number of leukocytes, platelets, neutrophils;
  • manifestations of hypersensitivity: urticaria, exfoliative dermatitis, Quincke's edema, anaphylaxis;
  • others: phlebitis is possible at the injection site, if injected intravenously quickly - low blood pressure, dizziness, asthenic syndrome, muscle relaxation.

special instructions

  • lincosamide should not be used during pregnancy;
  • when an antibiotic is prescribed during breastfeeding, feeding is suspended for the duration of treatment;
  • you cannot combine an antibacterial agent with muscle relaxants;
  • in case of severe bacterial infection, its use in combination with aminoglycoside drugs or other antibacterial agents active against gram-negative bacteria is recommended;
  • in case of liver or kidney dysfunction, the use of an antibiotic is possible only for health reasons, and with a long course of use, systematic monitoring of these organs is required;
  • if pseudomembranous colitis occurs, the use of the antibiotic should be stopped and vancomycin or bacitracin should be prescribed;
  • the antibiotic cannot be administered intravenously quickly;
  • When using lincomycin-based ointment, you must be careful in the presence of skin mycoses.

Drug interactions

  • when interacting with chloramphenicol, a decrease in the effectiveness of both drugs is observed, since chloramphenicol prevents lincomycin from binding to the ribosomes of bacterial cells;
  • aminosalicylic acid in combination with isoniazid causes impaired absorption of the antibiotic;
  • when combined with aminophylline, a decrease in the clearance of the latter drug may occur, which may require a reduction in its dosage;
  • lincomycin and ampicillin are antagonistic to each other;
  • synergistic interaction occurs when taken simultaneously with other aminoglycosides;
  • antidiarrheal drugs may reduce the effectiveness of the antibacterial action; the interval between taking these drugs should be at least 4 hours;
  • in combination with opioid analgesics, non-depolarizing muscle relaxants and halothane, it can enhance neuromuscular blockade, which threatens respiratory arrest;
  • when combined with theophylline as a single drug or with a combination of the latter with salbutamol, the concentration of the xanthine derivative may increase and the likelihood of its undesirable effects may increase;
  • the antibiotic causes increased activity of botulinum neurotoxin;
  • a decrease in the effectiveness of drugs occurs when taken together with josamycin;
  • when dioxomethyltetrahydropyrimidine and chloramphenicol in external form interact with lincomycin, the activity of all components decreases;
  • The antibiotic has pharmaceutical incompatibility with kanamycin;
  • it is necessary to discontinue the antibacterial drug several days before taking ketamine;
  • a side effect when combining an antibiotic with lanatoside C is the development of pseudomembranous colitis;
  • riboflavin in the form of a single drug and in combination with other medicinal substances when taken simultaneously with an antibiotic can cause a decrease in its activity;
  • simultaneous use with erythromycin is undesirable, since antagonism may develop when binding to a bacterial cell.

Lincomycin analogues

Lincomycin, both as an active ingredient and as a trade name, is a fairly common drug in the pharmacy range. Its analogues are also available in the form of capsules with a dosage of 250 mg and ampoules. The main difference between lincomycin-based drugs is bioavailability, quality and manufacturer.

The drug is produced in capsules by the following Russian manufacturers:

  • JSC Sintez;
  • Moskhimfarmpreparaty im. ON THE. Semashko;
  • ABVA-RUS;
  • Production of medicines;
  • Biochemist;
  • North Star.

The antibiotic in ampoules is produced by the following Russian manufacturers:

In the Republic of Belarus it is produced in the form of capsules by RUP Belmedpreparaty; in capsules and ampoules - Borisov ZMP.

Also registered on the Russian market are two antibiotics from a Chinese manufacturer in ampoules: Lincomycin hydrochloride (manufacturer: Sishui Xierkang Pharmaceutical Co.) and Lincomycin hydrochloride-Vial (Shandong Shenlou Pharmaceutical Co Ltd.)

In the form of an ointment for external use, the antibiotic is available under the name Lincomycin-AKOS, 10 and 15 g each. Manufacturer: Sintez OJSC.

Terms and conditions of storage

Lincomycin is suitable for use for 3 years from the date of production. Use after this period is prohibited. Proper antibiotic storage:

  • a place protected from light rays;
  • out of reach of children;
  • temperature degrees.

Lincomycin prices

The average cost of Lincomycin capsules in Moscow pharmacies is:

Source: http://bezboleznej.ru/linkomitsin