Hydrocortisone in gynecology

Posted on by admin

Hydrocortisone - instructions for use, analogs, reviews and release forms (eye ointment 0.5%, injections in ampoules, injection suspension) medications for the treatment of allergic and inflammatory diseases in adults, children and pregnancy

In this article you can read the instructions for use of the drug Hydrocortisone.

Table of contents:

Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Hydrocortisone in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Hydrocortisone analogues in the presence of existing structural analogues. Use for the treatment of allergic and inflammatory diseases in adults, children, as well as during pregnancy and lactation.

Hydrocortisone is a glucocorticosteroid that has an anti-inflammatory and antiallergic effect. Reduces inflammatory cell infiltrates, reduces the migration of leukocytes, incl. lymphocytes to the area of ​​inflammation. Stabilizes cellular and subcellular membranes, including lysosomal membranes and mast cell membranes. Reduces the binding of immunoglobulins to receptors on the surface of cells and inhibits the synthesis or release of cytokines (interleukins and interferons) from lymphocytes and macrophages.

Reduces the release of arachidonic acid from phospholipids and the synthesis of its metabolites (prostaglandins, leukotrienes, thromboxane).

Reduces the exudative reaction, helps reduce capillary permeability. Reduces the severity of the early immunological response.

It has an antimetabolic effect and inhibits the development of connective tissue and scarring.

Intended for intramuscular, intra- and periarticular administration, in order to provide systemic or local anti-inflammatory, as well as antiallergic effects. When administered intra-articularly, the therapeutic effect occurs within 6-24 hours and lasts several days or weeks.

When administered intra-articularly or periarticularly, hydrocortisone penetrates into the systemic circulation. Metabolized in the liver into tetrahydrocortisone and tetrahydrocortisol, which are excreted by the kidneys in conjugated form. Penetrates through the placental barrier.

  • rheumatic diseases accompanied by arthritis, incl. osteoarthritis in the presence of synovitis (with the exception of tuberculous, gonorrheal, purulent and other infectious arthritis);
  • rheumatoid arthritis;
  • glenohumeral periarthritis;
  • bursitis;
  • epicondylitis;
  • tenosynovitis;
  • allergic eye diseases (eyelid dermatitis, blepharitis, conjunctivitis and keratoconjunctivitis);
  • inflammatory diseases of the anterior part of the eye in the absence of a violation of the integrity of the corneal epithelium (blepharitis, conjunctivitis and keratoconjunctivitis);
  • thermal and chemical burns of the eyes (after complete epithelization of corneal defects);
  • acute adrenal insufficiency;
  • immediate allergic reactions;
  • status asthmaticus;
  • prevention and treatment of shock;
  • myocardial infarction complicated by cardiogenic shock;
  • thyrotoxic crisis;
  • thyroiditis;
  • congenital adrenal hyperplasia;
  • hypercalcemia due to tumor disease, short or additional therapy in the acute period of rheumatic diseases;
  • collagen diseases;
  • pemphigus;
  • bullous dermatitis herpetiformis (Dühring's disease);
  • polymorphous bullous erythema;
  • exfoliative dermatitis;
  • mycosis fungoides;
  • severe forms of psoriasis and seborrheic dermatitis;
  • severe acute and chronic allergic and inflammatory processes with eye damage;
  • symptomatic sarcoidosis;
  • Loeffler's syndrome, not responding to other types of therapy;
  • berylliosis;
  • focal or disseminated form of tuberculosis with simultaneous anti-tuberculosis chemotherapy;
  • aspiration pneumonitis;
  • secondary thrombocytopenia in adults;
  • acquired (autoimmune) hemolytic anemia;
  • erythroblastopenia;
  • congenital (erythroid) hypoplastic anemia;
  • palliative therapy for leukemia and lymphoma in adults;
  • for acute leukemia in children;
  • to increase diuresis or to reduce proteinuria in nephrotic syndrome without uremia, in idiopathic nephrotic syndrome or in lupus erythematosus;
  • in the critical stage of ulcerative colitis;
  • tuberculous meningitis with the development of subarachnoid block or its threat (in combination with anti-tuberculosis chemotherapy);
  • trichinosis with damage to the nervous system or myocardium;
  • bronchial asthma;
  • inflammation of the anterior part of the eyeball with intact corneal epithelium and after injuries and surgical interventions on the eyeball;
  • neurodermatitis;
  • psoriasis;
  • pruritus;
  • lichen planus verrucous.

Eye ointment 0.5%.

Suspension for intramuscular and intra-articular administration (injections in injection ampoules).

Ointment for external use 1% (ear, skin, nose).

There are no other forms, be it tablets or drops, of Hydrocortisone; perhaps these medications are counterfeits.

Instructions for use and dosage

1 cm of eye ointment is injected into the conjunctival sac 2-3 times a day.

The course of treatment is 1-2 weeks. On the recommendation of a doctor, the course of treatment can be extended.

Suspension for injection

Intra- and periarticular (into the joint).

In one day you can inject no more than 3 joints. Repeated administration of the injection is possible subject to a 3-week interval. Injection directly into a joint may have an adverse effect on hyaline cartilage, so the same joint can be treated no more than 3 times a year.

For tendinitis, the injection should be injected into the tendon sheath; it should not be injected directly into the tendon. Not acceptable for systemic treatment and for the treatment of Achilles tendon.

Adults: depending on the size of the joint and the severity of the disease, 5-50 mg intra- and periarticularly. In adults, the drug is administered intramuscularly deep into the gluteal muscle up to a day.

Children: 5-30 mg per day, divided into several doses. Single dose for periarticular administration to children aged 3 months to 1 year: 25 mg, from 1 year to 6 years: mg, from 6 to 14 years: mg.

For parenteral use. The dosage regimen is individual. It is used intravenously as a stream, intravenously by drip (in droppers), and rarely intramuscularly. For emergency treatment, intravenous administration is recommended. The initial dose is 100 mg (administered over 30 seconds) mg (administered over 10 minutes), then repeated every 2-6 hours, depending on the clinical situation. High doses should be used only until the patient’s condition stabilizes, but usually not more painfully, because hypernatremia may develop. Children - at least 25 mg/kg per day. In the form of a depot form, it is administered intra- or periarticularly at a dose of 5-50 mg once with an interval of 1-3 weeks. Intramuscular mg per day.

Ointment for external use

Externally once a day.

  • steroid diabetes mellitus or manifestation of latent diabetes mellitus;
  • suppression of adrenal function;
  • Itsenko-Cushing syndrome (including moon face, pituitary obesity, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, myasthenia gravis, stretch marks);
  • delayed sexual development in children;
  • hypocalcemia;
  • weight gain;
  • increased sweating;
  • retention of fluid and sodium ions (peripheral edema);
  • disorientation;
  • euphoria;
  • hallucinations;
  • affective insanity;
  • depression;
  • paranoia;
  • increased intracranial pressure;
  • nervousness or restlessness;
  • insomnia;
  • dizziness;
  • headache;
  • convulsions;
  • arrhythmias;
  • bradycardia (up to cardiac arrest);
  • development (in predisposed patients) or increased severity of chronic heart failure;
  • increased blood pressure;
  • with intracranial administration (into the nose) - nosebleeds;
  • nausea, vomiting;
  • steroid ulcer of the stomach and duodenum;
  • bleeding and perforation of the gastrointestinal tract;
  • increased or decreased appetite, flatulence;
  • hiccups;
  • sudden loss of vision (with parenteral administration in the head, neck, nasal turbinates, scalp, deposition of drug crystals in the vessels of the eye is possible);
  • tendency to develop secondary bacterial, fungal or viral eye infections;
  • slower growth and ossification processes in children (premature closure of epiphyseal growth zones);
  • osteoporosis (very rarely - pathological bone fractures, aseptic necrosis of the head of the humerus and femur);
  • muscle tendon rupture;
  • decreased muscle mass (atrophy);
  • with intra-articular injection - increased pain in the joint;
  • steroid acne;
  • striae;
  • generalized (including skin rash, skin itching, anaphylactic shock) allergic reactions;
  • local allergic reactions;
  • with parenteral administration - burning, numbness, pain, paresthesia and infection at the injection site, necrosis of surrounding tissues, scar formation at the injection site;
  • with intramuscular injection (especially into the deltoid muscle) - atrophy of the skin and subcutaneous tissue;
  • withdrawal syndrome;
  • itching;
  • hyperemia;
  • burning;
  • dryness;
  • allergic dermatitis.
  • increased sensitivity to hydrocortisone.

For intra-articular injection and injection directly into the lesion:

  • previous arthroplasty;
  • pathological bleeding (endogenous or caused by the use of anticoagulants);
  • intra-articular bone fracture;
  • infectious (septic) inflammatory process in the joint and periarticular infections (including a history), as well as a general infectious disease;
  • severe periarticular osteoporosis;
  • absence of signs of inflammation in the joint (“dry” joint, for example with osteoarthritis without synovitis);
  • severe bone destruction and joint deformation (sharp narrowing of the joint space, ankylosis);
  • joint instability as an outcome of arthritis;
  • aseptic necrosis of the epiphyses of the bones that form the joint.

For external use:

  • bacterial, viral, fungal skin diseases;
  • lupus;
  • skin manifestations of syphilis;
  • skin tumors;
  • post-vaccination period;
  • violation of the integrity of the skin (ulcers, wounds);
  • children's age (up to 2 years, with itching in the anus - up to 12 years);
  • rosacea;
  • acne vulgaris;
  • perioral dermatitis.

For use in ophthalmology:

  • bacterial, viral, fungal eye diseases;
  • tuberculous eye disease;
  • trachoma;
  • violation of the integrity of the ocular epithelium.

Use during pregnancy and breastfeeding

Use during pregnancy is possible only when the expected benefit to the mother outweighs the potential risk to the fetus; It is recommended to use minimal doses and short-term therapy. Children whose mothers received hydrocortisone during pregnancy should be closely monitored for signs of adrenal insufficiency.

If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.

Experimental studies have shown that glucocorticosteroids (GCS) can cause fetal developmental disorders. There is currently no clear confirmation of these data in humans.

Use with caution in case of parasitic and infectious diseases of a viral, fungal or bacterial nature (currently or recently suffered, including recent contact with a patient) - herpes simplex, herpes zoster (viremic phase), chickenpox, measles, amoebiasis, strongyloidiasis (established or suspected), systemic mycosis; active and latent tuberculosis. Use for severe infectious diseases is permissible only against the background of specific therapy.

Use with caution within 8 weeks before and 2 weeks after vaccination, with lymphadenitis after BCG vaccination, with immunodeficiency conditions (including AIDS or HIV infection).

Use with caution in diseases of the gastrointestinal tract: gastric and duodenal ulcers, esophagitis, gastritis, acute or latent peptic ulcers, recently created intestinal anastomosis, ulcerative colitis with the threat of perforation or abscess formation, diverticulitis.

Use with caution for diseases of the cardiovascular system, incl. after a recent myocardial infarction (in patients with acute and subacute myocardial infarction, the necrotic focus may spread, slowing down the formation of scar tissue and, as a result, rupture of the heart muscle), with decompensated chronic heart failure, arterial hypertension, hyperlipidemia), with endocrine diseases - diabetes mellitus ( including impaired tolerance to carbohydrates), thyrotoxicosis, hypothyroidism, Itsenko-Cushing's disease, with severe chronic renal and/or liver failure, nephrourolithiasis, with hypoalbuminemia and conditions predisposing to its occurrence, with systemic osteoporosis, myasthenia gravis, acute psychosis , obesity (grade 3-4), poliomyelitis (except for the form of bulbar encephalitis), open- and closed-angle glaucoma, pregnancy, lactation.

If intra-articular administration is necessary, use with caution in patients with a general severe condition, ineffectiveness (or short duration) of the action of 2 previous administrations (taking into account the individual properties of the corticosteroids used).

If hydrocortisone is insufficiently effective over time and longer-term therapy is necessary, it is advisable to replace hydrocortisone with another glucocorticoid drug that does not cause sodium retention in the body. During treatment with hydrocortisone, it is recommended to prescribe a diet with limited sodium and increased potassium content.

Relative adrenal insufficiency caused by hydrocortisone may persist for several months after its discontinuation. Taking this into account, in stressful situations that arise during this period, hormonal therapy is resumed with the simultaneous administration of salts and/or mineralocorticoids.

In patients with active tuberculosis, hydrocortisone should be used in combination with appropriate antituberculosis therapy. In the case of a latent form of tuberculosis or during the period of change in tuberculin tests, the patient’s condition should be carefully monitored, and, if necessary, chemoprophylaxis should be carried out.

With simultaneous use, hydrocortisone increases the toxicity of cardiac glycosides (due to the resulting hypokalemia, the risk of developing arrhythmias increases); with acetylsalicylic acid - accelerates its elimination and reduces its concentration in the blood plasma (when hydrocortisone is discontinued, the concentration of salicylates in the blood increases and the risk of side effects increases); with paracetamol - increased risk of developing the hepatotoxic effect of paracetamol (induction of liver enzymes and the formation of a toxic metabolite of paracetamol); with cyclosporine - increased side effects of hydrocortisone due to inhibition of its metabolism; with ketoconazole - increased side effects of hydrocortisone due to a decrease in its clearance.

Hydrocortisone reduces the effectiveness of hypoglycemic agents; enhances the effect of indirect anticoagulants of coumarin derivatives.

Hydrocortisone reduces the effect of vitamin D on the absorption of calcium ions in the intestinal lumen. Ergocalciferol and parathyroid hormone prevent the development of osteopathy caused by GCS.

Hydrocortisone increases the metabolism of isoniazid, mexiletine (especially in “fast acetylators”), which leads to a decrease in their plasma concentrations; increases (with long-term therapy) the content of folic acid; reduces the concentration of praziquantel in the blood.

Hydrocortisone in high doses reduces the effect of somatropin.

Hypokalemia caused by GCS can increase the severity and duration of muscle blockade due to muscle relaxants.

When used simultaneously with GCS, thiazide diuretics, carbonic anhydrase inhibitors, other GCS, amphotericin B increase the risk of hypokalemia, drugs containing sodium ions increase the risk of edema and increased blood pressure.

NSAIDs and ethanol (alcohol) increase the risk of developing ulceration of the gastrointestinal mucosa and bleeding; in combination with NSAIDs for the treatment of arthritis, it is possible to reduce the dose of GCS due to the summation of the therapeutic effect. Indomethacin, displacing GCS from its connection with albumin, increases the risk of developing its side effects.

The therapeutic effect of GCS is reduced under the influence of inducers of microsomal liver enzymes (including phenytoin, barbiturates, ephedrine, theophylline, rifampicin) due to an increase in the rate of metabolism of these substances.

Inhibitors of adrenal function (including mitotane) may require increasing the dose of GCS.

The clearance of GCS increases against the background of thyroid hormone preparations.

Immunosuppressants increase the risk of developing infections and lymphoma or other lymphoproliferative disorders associated with Epstein-Barr virus.

Estrogens (including oral estrogen-containing contraceptives) reduce the clearance of GCS, prolong T1/2 and their therapeutic and toxic effects. The appearance of hirsutism and acne is facilitated by the simultaneous use of other steroid hormonal drugs - androgens, estrogens, anabolic steroids, oral contraceptives.

Tricyclic antidepressants may increase the severity of depression caused by taking corticosteroids (not indicated for the treatment of these side effects).

The risk of developing cataracts increases when used in combination with other corticosteroids, antipsychotics (neuroleptics), carbutamide and azathioprine. Simultaneous administration with m-anticholinergic blockers, as well as with drugs that have an m-anticholinergic effect (including antihistamines, tricyclic antidepressants), with nitrates increases intraocular pressure.

With the simultaneous use of GCS with live antiviral vaccines and against the background of other types of immunization, the risk of viral activation and the development of infections increases.

Analogues of the drug Hydrocortisone

Structural analogues of the active substance:

  • Akortin;
  • Hydrocortisone Nycomed;
  • Hydrocortisone Richter;
  • Hydrocortisone-POS;
  • Hydrocortisone acetate;
  • Courtade;
  • Cortef;
  • Laticort;
  • Lokoid Krelo;
  • Lokoid lipocrem;
  • Solu-Cortef;
  • Sopolcourt N.

Source: http://instrukciya-otzyvy.ru/206-gidrokortizon-po-primeneniyu-analogi-maz-glaznaya-ukoly-v-ampulah-suspenziya-dlya-inekciy.html

What is Hydrocortisone ointment used for?

Hydrocortisone is a potent drug. In what cases does hydrocortisone ointment help and can it be used at home?

Composition and release form

Hydrocortisone ointment is intended for topical use. Its active substance is hydrocortisone acetate. This is an ester of hydrocortisone, which belongs to the steroid hormones from the group of glucocorticosteroids.

Hydrocortisone is produced by the adrenal cortex, and ester is obtained synthetically.

Hydrocortisone ointment is produced in aluminum tubes, the weight of which varies depending on the pharmaceutical company. 100 g contains from 1 to 2.5 g of active substance, which determines its percentage. The rest of the component is auxiliary components, which are Nipogen and Vaseline.

Hydrocortisone acetate as the main component is included in:

  1. Suspensions for injections. This is a white, distinctive-smelling injection liquid that may also contain lidocaine hydrochloride. Available in ampoules or bottles. Used for injection into muscles and joints.
  2. Eye ointment. Available in tubes. Prescribed for particularly severe inflammations of the eyes, including those of an infectious nature. It is administered conjunctivally.
  3. Tablets. Oral hydrocortisone acetate is used to treat systemic inflammation.

The dosage of any drug is determined by the patient’s well-being.

Therapeutic effect of the ointment

It is mainly provided by the main substance of the ointment Hydrocortisone. What does this medicine help with? It has the following effect:

When spread on the skin, it concentrates in one of the layers of the epidermis, where it begins to disintegrate. The further stage of the process ends in the liver. Decay products leave the body through the excretory organs.

When is it used?

The healing capabilities of the drug are used in the treatment of inflammation and allergic reactions that are not caused by pathogenic bacteria, viruses and fungi. Indications for the use of Hydrocortisone ointment include:

  • eczema that occurs as a result of allergies and due to disorders in the nervous, immune, and endocrine systems;
  • different types of dermatitis, the most common cause of which is an allergic reaction of the body;
  • psoriasis, related to anti-immune diseases;
  • severe insect bites;

It is possible to enhance the effect of Hydrocortisone ointment by using ultrasound. Ultrasound procedures using drugs are called phonophoresis.

When performing phonophoresis, the gel form of hydrocortisone is preferable because the gel is absorbed faster.

With the use of hydrocortisone, they are prescribed for inflammation of the joints, varicose veins, muscle atrophy, damage to the nervous system, fractures, and gynecological problems. This method of treatment can reduce the occurrence of side effects.

Traditional medicine includes ointment in the category of cosmetics. It is believed that it helps against wrinkles. But studies of such effects have not been carried out, so it is not worth talking about the anti-aging effect of the product.

Instructions for use

To feel the results of treatment with ointment, you need to follow the recommendations for its use:

  • apply a thin layer to the sore spot;
  • number of procedures per day - no more than 3;
  • the duration is determined by the nature of the disease and is 6-14 days, in complex cases - up to 20;
  • to speed up the action of the therapeutic component, an occlusive dressing is applied to prevent its contact with water and air.

But such dressings are excluded if the skin lesion occurs on the face or the patient is a small child aged 2 years or older. When treating children, the treatment period is strictly limited to two weeks.

Side effects

Since the glucocorticosteroid is used externally and locally, its systemic effect on the body is minimal, and an overdose is unlikely. But with long-term therapy, the following may occur:

The ingestion of excess medicinal substances into the body is accompanied by a sharp decrease in sugar levels, disruption of the activity of the adrenal cortex and the occurrence of pathologies of the endocrine system. Moreover, if the ointment has been used for a long time, it cannot be abruptly discontinued. This is done gradually.

Since the drug is based on a hormone, treatment of children is carried out under the supervision of a specialist. Possible growth inhibition, weight gain and increased plasma cortisol levels.

If after a week of treatment your health does not improve, the drug is discontinued.

With long-term therapy with hydrocortisone ointment, the patient is prescribed a diet with a reduced amount of sodium, high potassium and sufficient protein. In order to timely determine the negative impact of the drug on the body, you need to regularly measure blood pressure, blood glucose levels, weight, and blood clotting.

When is ointment contraindicated?

Hydrocortisone ointment is prohibited if the patient has:

  • skin pathologies caused by pathogenic bacteria, fungi or viruses;
  • ulcerative lesions;
  • wounds;
  • tuberculosis.

It is not recommended to use the product during pregnancy, lactation and children under 1 year of age.

There are known contraindications for the simultaneous use of ointment with barbiturates and antiallergic drugs that reduce the effect of glucocorticosteroids. It, in turn, enhances or reduces the effect of anticoagulants, paracetamol, salicylates and agents that normalize blood sugar levels.

If you are treated with a corticosteroid, cardiac and diuretic drugs at the same time, the likelihood of hypokalemia and an increase in the ability of tissues to retain water will increase. The combination with amphotericin is dangerous, as it contributes to the development of heart failure and other defects of this organ.

Cost of the drug and its analogues

How much does Hydrocortisone ointment cost? What analogues can replace it? And is it worth it?

A price comparison will clearly show which drug to choose.

The choice is obvious. Domestic pharmaceutical companies produce the cheapest product. Foreign manufacturers produce a similar drug, but more expensive.

Share this article with your friends

Diagnosis: Obliterating atherosclerosis. Aneurysm BOTH on the left. Occlusion of the SFA on both sides. Chronic

Source: http://tyubik.net/mazi-geli/35-dlya-chego-primenyaetsya-maz-gidrokortizon.html

Hydrocortisone

Release form

Lyophilisate d/prig. solution for intravenous injection. 25 mg, 100 mg, 500 mg

Eye ointment 5 mg/g, 25 mg/g, 100 mg/g

Ointment for nar. approx. 1 mg/g, 10 mg/g

Solution for intravenous injection. 50 mg/ml

Size d/nar. approx. 1 mg/ml

Susp. for intramuscular and intravenous injection. 25 mg/ml

Table 5 mg, 10 mg, 20 mg

Mechanism of action

Main effects

■ Unlike cytostatics, immunosuppressive properties are not associated with a mitostatic effect, but are the total result of suppression of different stages of immunogenesis: migration of stem cells (bone marrow), migration of B cells and interaction of T and B lymphocytes.

■ Promotes the deposition of glycogen in the liver.

■ Increases blood glucose levels.

■ Inhibits the excretion of Na+ and water.

■ Enhances the removal of K+ from the body.

■ Reduces histamine synthesis.

■ Reduces inflammatory cell infiltrates.

■ Reduces the migration of leukocytes and lymphocytes to the area of ​​inflammation.

■ In large doses, it inhibits the development of lymphoid and connective tissue, incl. Riticuloendothelial system.

■ Reduces the number of mast cells, which are the site of hyaluronic acid formation.

■ Suppresses hyaluronidase and helps reduce capillary permeability.

■ Delays the synthesis and accelerates the breakdown of proteins.

■ By affecting the pituitary gland, it inhibits the production of corticotropin.

■ Long-term administration into the body can lead to decreased function and atrophy of the adrenal cortex, inhibition of the formation of gonadotropic and thyroid-stimulating hormones of the pituitary gland.

Pharmacokinetics

Gel for external use: after application it accumulates in the epidermis (mainly in the granular layer). Metabolized directly in the epidermis, and subsequently in the liver. Excreted by the kidneys and bile.

Indications

■ allergic and inflammatory diseases of the oral mucosa and periodontium: stomatitis, lichen planus, glossitis, cheilitis, periodontitis (in complex therapy);

■ arthritis and arthrosis of the temporomandibular joint;

■ in endodontics - to relieve the inflammatory process in the pulp and periapical tissues: pulpitis, periodontitis.

■ systemic lupus erythematosus, bullous pemphigoid, lichen planus (in complex therapy);

■ emergency care for shock (burn, traumatic, surgical, toxic, cardiogenic) when other therapy is ineffective;

■ allergic reactions (acute, severe forms), blood transfusion shock, anaphylactic shock, anaphylactoid reactions;

■ bronchial asthma (severe form), status asthmaticus;

■ poisoning with cauterizing liquids (reducing inflammation and preventing cicatricial contractions).

Directions for use and doses

IM (deep into the gluteal muscle) - at a dose of 125-250 mg/day. The pharmacodynamic effect occurs 6-25 hours after administration and lasts several days or weeks.

Contraindications

■ Viral and fungal diseases.

■ Severe form of tuberculosis (active form).

■ Gastric ulcer.

■ Severe forms of hypertension.

■ Young children.

■ bacterial, viral and fungal diseases of the skin and mucous membranes (pyoderma, skin tuberculosis, mycosis);

■ violation of the integrity of the skin (ulcers, wounds);

■ children's age (up to 2 years);

Cautions, therapy monitoring

- in patients with an active form of infectious diseases, use only in combination with antibacterial agents;

— some forms of drugs in the solvent contain benzyl alcohol, which is sometimes associated with the development of fatal gasping syndrome in premature infants;

- children whose mothers received hydrocortisone during pregnancy are subject to careful monitoring to identify signs of adrenal insufficiency;

- in children during the growth period, GCS should be used only for absolute indications and under the especially careful supervision of the attending physician;

■ for gel, ointment, solution for external use:

— pregnancy (first trimester);

— tuberculosis (systemic lesion);

Side effects

■ decreased glucose tolerance;

■ “steroid” diabetes mellitus or manifestation of latent diabetes mellitus;

■ suppression of adrenal function;

■ Itsenko-Cushing syndrome (moon-shaped face, pituitary-type obesity, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, myasthenia gravis, stretch marks);

■ delayed sexual development in children. From the digestive system:

■ “steroid” ulcer of the stomach and duodenum;

■ bleeding and perforation of the gastrointestinal tract;

■ increase or decrease in appetite;

■ in rare cases - increased activity of liver transaminases and alkaline phosphatase.

■ bradycardia (up to cardiac arrest);

■ development (in predisposed patients) or increased severity of chronic heart failure;

■ ECG changes characteristic of hypokalemia;
■ in patients with acute and subacute myocardial infarction - the spread of necrosis, slowing down the formation of scar tissue, which can lead to rupture of the heart muscle.

■ increased intracranial pressure;

■ nervousness or anxiety;

■ sudden loss of vision (with parenteral administration in the head, neck, nasal turbinates, scalp, deposition of drug crystals in the vessels of the eye is possible);

■ posterior subcapsular cataract;

■ increased intraocular pressure with possible damage to the optic nerve;

■ tendency to develop secondary bacterial, fungal or viral eye infections;

■ trophic changes in the cornea;

■ increased excretion of Ca2+;

■ increase in body weight;

■ negative nitrogen balance (increased breakdown of proteins);

■ fluid and Na+ retention caused by mineralocorticoid activity (peripheral edema);

■ hypokalemic syndrome (hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue).

■ slowing down of growth and ossification processes in children (premature closure of epiphyseal growth zones);

■ osteoporosis (very rarely - pathological bone fractures, aseptic necrosis);

■ rupture of muscle tendons;

■ decrease in muscle mass (atrophy).

■ delayed wound healing;

■ hyper- or hypopigmentation;

■ tendency to develop pyoderma and candidiasis.

■ generalized (skin rash, skin itching, anaphylactic shock).

■ development or exacerbation of infections (the appearance of this side effect is facilitated by jointly used immunosuppressants and vaccination);

■ paresthesia and infection at the injection site;

■ rarely - necrosis of surrounding tissues;

■ formation of scars at the injection site, atrophy of the skin and subcutaneous tissue with intramuscular injection (injection into the deltoid muscle is especially dangerous);

■ with intravenous administration: arrhythmias, “flushes” of blood to the face, convulsions;

■ with intracranial administration - nosebleeds;

■ with intra-articular injection - increased pain in the joint.

■ with long-term use (especially with occlusive dressings and/or application to large surfaces) - systemic side effects.

Interaction

Synonyms

Sulfonamides are broad-spectrum bacteriostatic drugs, competitive antagonists of paraminobenzoic acid (PABA), which is necessary for most microorganisms to...

The goal of rational antibacterial chemotherapy is to select the most active drug for a given pathology and its dose, which allows creating in the tissues the concentration necessary to suppress the growth of pathogenic microflora during the entire course of treatment. Method of administration of antimicrobial drugs and duration.

Antiseptics are broad-spectrum antimicrobial drugs that cause protein denaturation and do not have selective action. They are used externally to disinfect skin, mucous membranes, dental tissues, wound surfaces, as well as to disinfect dental instruments.

Video about the sanatorium Rimski Dvor, Roman Terme, Slovenia

Only a doctor can diagnose and prescribe treatment during a face-to-face consultation.

Scientific and medical news about the treatment and prevention of diseases in adults and children.

Foreign clinics, hospitals and resorts - examination and rehabilitation abroad.

When using materials from the site, the active reference is obligatory.

Source: http://medbe.ru/materials/lekarstva-v-stomatologii/gidrokortizon-/

Hydrocortisone ointment: instructions for use, analogues, contraindications

The active substance of the hormonal drug Hydrocortisone ointment is a glucocorticosteroid that has an anti-inflammatory, anti-allergic, anti-edematous effect, and also eliminates itching of the skin.

The product is used externally and has a number of side effects that everyone should be aware of.

Pharmacological action of the drug

The active ingredient of the product is a synthetic analogue of adrenal hormones. The ointment is available in two versions - for the eye with a concentration of 0.5% and for use on the skin - 1%.

The drug relieves the inflammatory reaction in the skin by reducing the migration of lymphocytes and leukocytes in the affected area and suppressing the production of prostaglandins - direct participants in inflammation and pain.

The next pharmacological effect of Hydrocortisone ointment is to eliminate itching and have an anti-exudative effect.

The product reduces collagen production and blocks fibroblast activity. Due to this, the risk of developing scars in the area of ​​inflammation and proliferation of connective tissue, for example, with psoriasis, is reduced.

Hydrocortisone ointment is effective for quickly eliminating swelling in acute allergic reactions. The drug retains moisture in the skin and has a keratolytic (softening) effect, so its use is effective for dry psoriatic and eczematous lesions.

After application, hydrocortisone accumulates in the granular layer of the epidermis, and here, and later in the liver, its metabolism (decomposition) begins. The substance is excreted with bile through the intestines and urine.

What is Hydrocortisone ointment used for?

The drug is used for local treatment of inflammatory and allergic skin pathologies. The instructions for use of Hydrocortisone ointment indicate the following indications:

  • psoriatic lesions;
  • contact and allergic dermatitis;
  • eyelid pathologies (blepharitis, conjunctivitis, keratoconjunctivitis, dermatitis);
  • neurodermatitis;
  • pruritus;
  • lichen planus verrucous;
  • seborrhea;
  • different forms of eczema.

Hydrocortisone ointment - Instructions for use

Instructions for use of hydrocortisone ointment

Apply a thin layer of ointment to the skin 2-4 times a day and rub in gently. If inflammatory infiltration occurs, then the product is used with an occlusive dressing - this is a hermetically sealed insulation of the skin from moisture and air.

The duration of the treatment course is 1-2 weeks, it can be changed at the discretion of the doctor depending on the severity and type of disease.

In the treatment of blepharitis and other eye diseases, 3 to 5 times a day, Hydrocortisone ointment is placed behind the lower eyelid, squeezing 1 cm of the product out of the tube. During application, you need to tilt your head back and then close your eyes.

If the ointment is injected into the conjunctival area, it is important to be careful not to touch the mucous membrane with the tube's nose.

A combination such as ultrasound with hydrocortisone ointment is often used.

This procedure is called phonophoresis; it is effective in the treatment of post-burn scars, neuralgia, articular and gynecological pathologies, muscle atrophy, trophic ulcers, varicose lesions, diseases of the ENT organs, fractures of long bones and painful injuries.

Hydrocortisone ointment for wrinkles

There are several theories of aging, and one of them says that age-related skin changes are caused by a decrease in the production of steroid hormones in the adrenal cortex. In this regard, many people are wondering whether it is possible to use Hydrocortisone ointment for wrinkles?

The fight against skin aging and anti-aging care require regularity, so the use of hydrocortisone for this purpose is not only unjustified, but also risky.

Using the ointment for 1-2 weeks will give a short-term effect, and a long period of use is fraught with at least an increase in wrinkles, and in the worst case, skin atrophy, disruption of internal organs, diabetes and other systemic and endocrine problems.

To prolong youth, it is better to choose an integrated approach, including facial massage, the use of oils and special cosmetic creams, proper nutrition and taking vitamins.

Hydrocortisone ointment for children

For children, hydrocortisone ointment can be used starting from the age of two, but only as directed and under strict medical supervision. The duration of the course is also determined only by the doctor.

When applying the ointment, do not apply fixing or warming bandages, that is, it is unacceptable to enhance the absorption of hydrocortisone. Children under 12 years of age should not apply the product to the anus.

Children are often prescribed antibiotic or antifungal medications along with this drug. If within a week treatment with Hydrocortisone ointment does not bring results or at least relief, you should stop using it and consult a doctor.

In childhood, suppression of the activity of the adrenal cortex and the production of growth hormones develops faster than in adults, so the use of any hormonal agents should be carried out carefully.

Hydrocortisone ointment - analogues

List of analogues of Hydrocortisone ointment:

Side effects

If the drug is used as prescribed by a doctor and in strictly recommended dosages, it does not cause suppression of the endocrine system and the development of complications. Otherwise, there is a high risk of developing allergic reactions.

With long-term use, the side effects of Hydrocortisone ointment can be systemic due to disruption of the pituitary gland, adrenal cortex and hypothalamus.

  • from the skin - atrophy, stretch marks, fungal skin infections, acne, pigmentation disorders, hemorrhages and slow healing of wounds and injuries;
  • from the eyes - cataracts, deterioration or loss of vision, secondary eye infections, increased intraocular pressure.
  • diabetes;
  • osteoporosis due to calcium leaching;
  • cramps and muscle pain, heart failure due to potassium leaching;
  • swelling due to sodium and water retention in the body;
  • obesity;
  • weakened immunity;
  • excessive sweating;
  • problems with digestion and liver function, steroid stomach ulcer;
  • hypertension, thrombosis, tachycardia (accelerated heart rate).

Contraindications

The drug should not be used in case of individual intolerance to hydrocortisone and other glucocorticoids. Hydrocortisone ointment is also contraindicated for:

  • syphilis rashes;
  • tuberculosis of the eyes and skin;
  • in the period after vaccination;
  • skin cancer;
  • under two years of age;
  • viral, fungal and bacterial infections of the eyes and skin;
  • impaired integrity of the skin (ulcers, wounds, abrasions) or eye epithelium;
  • perioral dermatitis;
  • acne vulgaris and rosacea;
  • trachoma.

Storage

Hydrocortisone ointment should be stored in a place protected from children and animals at an air temperature of 10-20°C. The shelf life of the drug is 3 years.

  • Author: Administrator
  • Print
  1. 5
  2. 4
  3. 3
  4. 2
  5. 1

Symptoms and treatment

The information is provided for informational and reference purposes; a professional doctor should make a diagnosis and prescribe treatment. Do not self-medicate. | User Agreement | Contacts | Advertising | © 2018 Medical Consultant - Health On-Line

Source: http://medknsltant.com/gidrokortizonovaya-maz-instruktsiya-po-primeneniyu-analogi-protivopokazaniya/

For what diseases will ultrasound (phonophoresis) with hydrocortisone help?

Often, for diseases of the musculoskeletal system, in addition to the main treatment, auxiliary treatment is also prescribed. It carries an equally important function. Experts say that physiotherapeutic treatment will help with almost any disease of the joints and spine, various inflammatory processes and the consequences, even complex ones, of injuries. One of the most popular is phonophoresis. This method has a combined effect on the affected areas of the body: using ultrasound and the active substances of the drug, previously applied to the skin.

The principle of its operation is as follows: as a result of the directed influence of ultrasonic waves generated by a special device, micro-oscillations are created in the sore spot, which heat up fluids and improve blood and lymph circulation, which in turn improves metabolism, relieves spasm and swelling. The permeability of the skin layers and mucous membranes also increases, which allows the active substances of the ointment, gel, cream, emulsion or other external agents to reach the epicenter of pain and inflammation and eliminate them.

Areas of application

All phonophoresis procedures are carried out in conjunction with anti-inflammatory and analgesic drugs. Doctors often use hydrocortisone - this is a hormone, a kind of analogue of a substance produced by the human adrenal glands. It is an anti-inflammatory agent. Suppresses the production of histamine and reduces sensitivity in tissues and organs.

Phonophoresis with hydrocortisone is used in the following areas:

  • various types of scars - burns, after wounds, postoperative;
  • diseases of the spine - vertebral hernia, scoliosis, osteochondrosis;
  • autoimmune disorders;
  • gynecology - mastitis, adnexitis, hypogalactia, adhesions;
  • joint diseases - arthrosis, arthritis, bursitis;
  • neurology – sclerosis, myopathy, polyneuritis, phantom pain, enuresis in children;
  • treatment for fractures of long bones;
  • diseases of the ENT organs - rhinitis, sinusitis, tonsillitis;
  • skin - eczema, neurodermatitis, trophic ulcers;
  • with muscle atrophy.

The technique is similar in all cases and is carried out in several stages:

  1. First, the doctor must treat the skin around the lesion with an antiseptic.
  2. After that, hydrocortisone ointment is applied to the desired area with a special spatula. It is very important to apply the ointment evenly, which promotes good absorption of the components.
  3. After the preparatory procedures, the doctor places a sensor on the lesion.
  4. Thanks to ultrasonic waves, the ointment begins to penetrate the skin.

All the action of high waves occurs at a depth of up to 3 centimeters from the surface. So it can affect various types of scars and small joints. Low frequencies penetrate more deeply up to 6 centimeters. They are prescribed as a treatment for various diseases of the spine and large joints.

Doctors prescribe treatment sessions every other day, depending on the specifics of the disease. The duration of each session is from 15 to 30 minutes. The drug remains on the skin for about two hours and has a therapeutic effect, so it is not recommended to wash off the ointment immediately after the procedure.

Despite the fact that ultrasound treatment is indicated for many pathologies, it is most often used:

For diseases of the joints and spine

Heel spur treatment

One of the common diseases of modern man is heel spur. It manifests itself as pain in the heel. Visualized as a bony protrusion in the form of a spike on the foot. When walking, a person experiences acute pain, as if constantly stepping on a nail. The cause of the disease is inflammation of the aponeurosis.

When treating this disease with phonophoresis, 8 to 12 sessions are prescribed, which are carried out every other day or daily, depending on the recommendations of the attending physician. The procedure takes about 10 minutes. A product (cream or ointment) based on hydrocortisone is applied to the heel area, after which ultrasound begins to work - for this, the sensor is placed on the painful area and held motionless, or moved over the surface with light massaging movements.

Treatment of the knee joint

This physiotherapeutic procedure is prescribed for many joint problems, incl. knees. Starting from classic arthritis and atroses to bursitis, tendinosis, gout. In addition, ultrasound helps to effectively treat traumatic injuries of cartilage, ligaments, incl. meniscus, various joints.

The number of sessions performed is prescribed by the attending physician based on the specifics of the disease. First, the knee joint is prepared for the procedure according to the general scheme described above, then the doctor places sensors in the right places and delivers wave vibrations at different frequencies. To obtain a successful result, the course must be at least 10 sessions. The duration of each session is minutes. After which it is not recommended to wash off the ointment for 1.5-2 hours. This way, the necessary substances will be absorbed to a depth of 6 cm.

In the treatment of gynecological diseases

Phonophoresis with hydrocortisone, used in gynecology, can be prescribed for inflammatory processes (ovaries, appendages), cervical erosions, effectively copes with menstrual irregularities, helps with infertility, and promotes the resorption of various types of scars after surgery.

The procedure can be carried out in two ways:

  • If a girl has problems, then the ointment is applied to the lower abdomen, previously wiped with an antiseptic, and the hypogastric, suprapubic and inguinal areas are treated with the device. In extreme cases, when a more targeted effect is required, the probe can be inserted through the rectum, but this treatment is not often practiced.
  • if the pathology manifests itself in a woman, then a special vaginal emitter is used, onto which a condom is placed, then it is thickly lubricated with hydrocortisone ointment and inserted into the vagina. In this case, the medicinal substances appear directly in the inflamed area, without being absorbed throughout the body. This targeted technique allows you to speed up the healing process.

All procedures are prescribed by the attending physician, depending on the specifics of the disease. Session length can vary from 4 to 15 minutes, and the number of sessions prescribed can range from 10 to 15.

Side effects

Sometimes phonophoresis with hydrocortisone can cause itching and swelling at the site of the device’s action, as well as hyperemia. Also in some cases there is an increase in blood pressure.

Contraindications

Contraindications to the use of U-sound:

  • various types of blood diseases that are associated with impaired blood clotting;
  • diabetes mellitus in severe forms;
  • pregnancy;
  • renal failure;
  • bronchial asthma;
  • various pustular skin lesions;
  • immunodeficiency;
  • cardiovascular diseases - angina pectoris, coronary heart disease;
  • colds accompanied by fever;
  • benign and malignant tumors.

Contraindications to the use of Hydrocortisone:

  • violation of the integrity of the skin;
  • pregnancy and breastfeeding;
  • individual intolerance to components;
  • severe forms of tuberculosis, diabetes.

Using phonophoresis at home

Thanks to modern technologies, today it is possible to carry out physiotherapeutic procedures in the comfort of your own home, which will save time on trips to medical institutions. To do this, you will need a special device that generates high-frequency waves, i.e. ultrasound. Such home devices are less powerful than those used in medical institutions. But they are compact, relatively inexpensive, very simple and convenient:

“Delta Combi” (Russia, retail price from 15,000 rubles)

The compact device, weighing just over a kilogram, having only 4 control buttons and an informative display, can operate in 3 modes: ultrasound therapy, transcutaneous electrical neurostimulation (TENS for short) and in both at once. With its help, you can not only get rid of a number of chronic diseases, and, if necessary, relieve severe pain and fatigue, but also carry out cosmetic procedures.

  • Dimensions 358x64x97 mm
  • Supply voltage 15 V
  • Consumption 10 W
  • Timer 10 min.
  • 7 programs for 2 modes

UZT-1.01.F “ARSA” (Russia, retail price from 7,900 rubles)

A small, convenient device, weighing just under a kilogram, works only in ultrasound mode. Simplicity of control (only 3 buttons) and a clear display, combined with high efficiency in the treatment of all major systems of the body, as well as the restoration of youth, thanks to the possibility of carrying out cosmetic procedures, make it in demand on the market. Another plus is that it informs you about the end of the timer with a sound signal.

  • Dimensions 240x78x52 mm
  • Supply voltage 220 V
  • Power 8 W
  • Timer from 1 to 10 min.
  • Operating mode 10 min, break 5 min

OUT-n 01 “Reton” (Russia, retail price from 3,000 rubles)

A small-sized, lightweight (no more than 0.5 kg), which does not require any settings, the ultrasound device not only has a therapeutic effect on most diseases of the main body systems, but also has an analgesic, antipruritic, antiseptic, desensitizing, and absorbable effect.

  • Dimensions 80x60x40 mm
  • Supply voltage 220 V
  • Power 4.8 W
  • Oscillation frequency 110 kHz

In conclusion, I would like to once again dwell on the main positive aspects of this treatment method:

  • painlessness;
  • a wide range of treatable diseases;
  • minimal number of negative manifestations from the procedures;
  • rapid delivery of medicinal substances to the required area;
  • does not have a destructive effect on the gastrointestinal tract;
  • scanty concentration of hormones in the body;
  • the effect of the drug continues after the end of the procedure.

Reviews

Many people who have undergone phonophoresis with hydrocortisone at home or in a medical institution note its positive effects. The pain threshold decreases and the general condition of the body improves. Many diseases either go into long-term remission or disappear altogether. All treatment provided has an excellent overall therapeutic effect.

It should also be noted that many women who were prescribed this procedure as a treatment for infertility are afraid to do it, because... We are not sure that the presence of a hormonal agent in the body will have a good effect on the unborn baby. At the same time, those who decided to take this step and became happy parents are reassured in every possible way and advised to trust the doctors.

  • Does pain limit your movements and full life?
  • Are you worried about discomfort, crunching and systematic pain?
  • Perhaps you have tried a bunch of medications, creams and ointments?
  • People who have learned from bitter experience use it to treat joints. Read more >>

Editor and expert of the site zdorovya-spine.ru. Specialization: general practitioner. More than 10 years of experience. City clinic, Smolensk. Graduated from the Smolensk State Medical Academy with a degree in general medicine. I really love my profession.

The Chinese have revealed to the whole world a method of how to treat joints in 2 days! Write the recipe before it gets deleted.

Your joints will look like they were at 25 years old! Chinese doctor: To get rid of joint pain, you need to exclude.

The joints will stop aching the next day if you apply a penny in the evening.

Add a comment Cancel reply

we are in social networks

WE ARE IN VK

Categories

Drugs and medications

Read also

DO NOT SELF-medicate. THE INFORMATION PROVIDED ON THE SITE IS FOR POPULAR INFORMATIONAL INFORMATION AND CANNOT REPLACE A FACE-TO-FACE CONSULTATION WITH A DOCTOR!

By using this site, you agree to the use of cookies in accordance with this cookie type notice. If you do not agree to our use of this type of file, you should set your browser settings accordingly or not use the site

Source: http://zdorovya-spine.ru/preparaty-i-lekarstva/ultrazvuk-s-gidrokortizonom.html