Phenylephrine hydrochloride price

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Phenylephrine

Description current as of 10/09/2015

  • Latin name: Phenylephrinum
  • ATX code: C01CA06, R01AA04, S01GA55, R01AB01, R01BA03, R01BA53
  • Chemical formula: C 9 H 1 3 NO 2
  • CAS code:

Chemical name

(R)-3-Hydroxy-alpha-[(methylamino)methyl]benzenemethanol (as hydrochloride)

Table of contents:

Chemical properties

Phenylephrine hydrochloride is a white or white with a yellowish tint crystalline powder, odorless. The product dissolves well in alcohol and water. In order for the solution to be administered by injection, it is first sterilized for half an hour at a temperature of 100 degrees Celsius, the pH ranges from 3 to 3.5.

Phenylephrine Hydrochloride, what is it?

Phenylephrine is a synthetic alpha-adrenergic agonist, alpha-adrenergic receptor stimulant, and anticongestant.

Molecular mass of the substance = 167.2 grams per mole. Melting point is approximately 134 degrees Celsius.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

The drug acts primarily on postsynaptic alpha-adrenergic receptors and has virtually no effect on beta-adrenergic receptors of the heart muscle. The substance constricts arterioles, increases blood pressure, and can cause reflex bradycardia. However, compared to adrenaline and norepinephrine, the drug does not increase blood pressure as rapidly, but lasts much longer. The medicine does not increase cardiac output; some studies show that Phenylephrine, on the contrary, slightly reduces this indicator.

The substance slightly stimulates the functioning of the spinal cord and brain, reduces renal and skin blood flow, and stimulates blood circulation in the extremities and abdominal cavity. Under the influence of the drug, the pulmonary vessels narrow and the pressure in the pulmonary artery increases. The substance also has an anticongestive effect, it reduces swelling of the nasal mucosa, reduces pressure in the middle ear and paranasal cavities, and restores normal breathing through the nose.

Due to the fact that this substance is not a catecholamine, it is not subject to the action of the COMT enzyme, the drug is not metabolized longer and its effect is longer lasting. The effectiveness of the drug when taken orally is quite high. However, the most effective is parenteral administration of the drug.

The biological transformation of the drug occurs in the liver. The drug is excreted in the form of metabolites through the kidneys. Phenylephrine hydrochloride begins to act immediately after injection and continues for 20 minutes (up to 50 when administered subcutaneously). After an intramuscular injection, the effect of the medicine is observed within 1-2 hours.

When used topically (ophthalmology), the substance dilates the pupil, stimulates the process of outflow of intraocular fluid, and constricts blood vessels. After instillation, the drug causes contraction of the pupillary dilator and smooth muscles of the arterioles of the conjunctiva. 4-6 hours after instillation, the pupil returns to its original shape and size. Due to the fact that the drug has a slight effect on the ciliary muscle, mydriasis occurs without cycloplegia.

After contact with the mucous membrane of the eye, Phenylephrine quickly and easily penetrates the tissue of the eye. The pupil dilates within 10 minutes to an hour after instillation. Sometimes, minutes after instillation, small particles of pigment can be found in the anterior chamber, exfoliated from the pigment leaf of the iris.

The use of the drug during inhalation and subdural anesthesia to maintain normal blood pressure levels is also described. The drug was used for paroxysmal supraventricular tachycardia, Berzold-Jarisch reflex, secretory prerenal anuria, priapism and anaphylaxis.

Indications for use

Phenylephrine is prescribed orally and topically to reduce swelling of the nasopharyngeal mucosa during allergies and colds (rhinitis, sinusitis, flu, hay fever).

  • with acute arterial hypotension;
  • patients with vascular insufficiency (may develop due to an overdose of vasodilators);
  • with toxic or traumatic shock;
  • as a vasoconstrictor when using local anesthesia.

Phenylephrine eye drops are used:

  • as a prophylactic for iridocyclitis;
  • to dilate the pupil for diagnostics in ophthalmology;
  • when conducting a provocative test in patients with suspected angle-closure glaucoma;
  • to dilate the pupil before surgery on the eyes and fundus (use 10% solution);
  • during differential diagnosis of the type of eyeball injection;
  • in vitreoretinal surgery;
  • for the treatment of glaucomocyclic crises;
  • with “red eye syndrome”.

Rectal suppositories are also used to treat hemorrhoids.

Contraindications

All dosage forms of the substance cannot be used if you are allergic to Phenylephrine.

Solution for injection is contraindicated:

  • patients with ventricular fibrillation;
  • with high blood pressure (it is necessary to closely monitor blood pressure and perform infusion at low speed);
  • patients with hypertrophic obstructive cardiomyopathy;
  • with decompensated heart failure;
  • persons suffering from obvious atherosclerosis;
  • with severe ischemic disease;
  • patients with pheochromocytoma;
  • with lesions of the cerebral arteries.

The solution is used with caution:

Eye drops are not used:

  • for treatment or diagnostics in patients with angle-closure, narrow-angle glaucoma or violations of the integrity of the eyeball;
  • in elderly patients with serious disorders of the cerebrovascular or cardiovascular system;
  • in case of disturbances in the process of tear production;
  • in patients with congenital deficiency of glucose-6-phosphate dehydrogenase;
  • with hyperthyroidism;
  • in children under 12 years of age;
  • with hepatic porphyria;
  • with insufficient body weight in children.

A 10% solution cannot be instilled in case of arterial aneurysm.

Nasal drops are contraindicated:

Nasal spray is contraindicated in the same cases as drops. Also, the spray is not used to treat children under 6 years of age or with high blood pressure.

Side effects

When using Phenylephrine, you may develop:

When using eye drops, the following are observed: burning, eye irritation, increased lacrimation, blurred vision.

Nasal drops and spray after instillation cause a burning and tingling sensation on the nasal mucosa.

Phenylephrine, instructions for use (Method and dosage)

Depending on the dosage form and indications, the drug is used as an injection, instilled into the nose or eyes.

When taken orally, the recommended single dose is 30 mg. You can take up to 150 mg of the drug per day. The course of treatment is determined by the doctor.

Phenylephrine injections, instructions for use

The drug is administered subcutaneously, intramuscularly and intravenously using infusions or a slow stream. The dosage depends on the patient's condition and indications.

For jet administration, 10 mg of the product must be diluted in 9 ml of water for injection. When performing an infusion, the medicine is diluted based on 10 mg of the substance per 500 ml of 0.9% NaCl or 5% glucose.

With a moderate decrease in blood pressure, the medicine is administered subcutaneously or intramuscularly. A single dosage for an adult is from 2 to 5 mg. After some time, if necessary, you can administer another 1-10 mg of the drug. 0.2 mg is administered intravenously, slowly in a stream.

It is recommended to maintain an interval of minutes between injections.

If the patient has developed severe hypotension or shock, the substance is administered intravenously at a rate of 0.18 mg per minute. In the process of stabilizing blood pressure and the patient's condition, the infusion rate can be reduced to 0.06 mg per minute.

When using the drug as a vasoconstrictor, it is added to the anesthetic solution and administered along with it (approximately 0.4 mg of a 1% solution per 10 ml of liquid anesthetic).

The maximum single dosage for an adult is 10 mg, and the daily dosage is 50 mg. When administered intravenously, 5 mg of the drug can be administered at a time, up to 25 mg per day.

Instructions for eye drops

Phenylephrine 1-2% solution is injected into the conjunctival sac, 2-3 drops. It should be remembered that the effect of using the product will last several hours.

Phenylephrine nasal drops for children

Children under one year of age are prescribed 1 drop in each nostril. The frequency of use of the medicine is no more than once every 6 hours.

Children under 6 years old can take 2 drops, over 6 years old – 4 drops. The course of treatment is 3 days.

The nasal spray can only be prescribed for children over 12 years of age. It is recommended to do 2-3 injections into each nasal passage no more than once every 4 hours.

Rectal suppositories are administered 2 times a day in the morning and before bedtime, after bowel movements. A maximum of 4 candles can be used per day.

Overdose

In case of an overdose, ventricular extrasystole and tachycardia occur, a feeling of heaviness in the legs, arms and head, and a rapid increase in blood pressure.

Interaction

Sympathomimetics enhance the arrhythmogenicity and pressor effect of phenylephrine.

When this substance is combined with halothane, cyclopropane or other general anesthetic agents, ventricular fibrillation may occur.

MAO inhibitors enhance the effect of the drug, including when used topically. It is necessary to take a break between drugs of at least 21 days.

When combining the drug with guanethidine, the effect of the drug on mydriasis is enhanced.

Beta blockers can reduce cardiac pacing as a result of taking the drug. When combining the drug with reserpine, arterial hypertension may develop.

Terms of sale

special instructions

If during therapy with the drug the blood pressure sharply increases, bradycardia or tachycardia, or heart rhythm disturbances develop, then it is necessary to interrupt the treatment. To ensure that blood pressure does not drop too sharply, the dose is reduced gradually, especially after a long infusion.

It should be remembered that when used topically, the active component of eye drops can be absorbed into the systemic circulation through the mucous membrane.

During therapy with the drug, blood pressure, cardiac output, pressure in the pulmonary artery, blood circulation at the injection site and in the extremities should be monitored, and an ECG should be performed.

If the patient has arterial hypertension, it is recommended to maintain systolic blood pressure 40 mmHg lower than usual.

After using this substance in any dosage form, it is recommended to refrain from driving a car and performing work that requires rapid psychomotor reactions.

For children

Parenteral administration of the substance to children is not recommended. When used topically, Phenylephrine can be absorbed into the systemic circulation, so 10% eye drops should not be administered to infants.

Elderly

It is recommended to avoid administering the drug by injection and treatment with 10% eye drops in elderly people.

During pregnancy and lactation

There have been no strictly controlled, adequate clinical studies of the effect of the drug on the fetus during pregnancy and on the child during breastfeeding. Therefore, the medicine can be used during pregnancy and lactation only after consultation with a specialist.

Drugs containing (Analogs)

Trade names of this substance: Vizofrin, Irifrin BK, Nazol Kids and Nazol Baby, Relief, Mezaton, Phenylephrine hydrochloride, Irifrin, Neosinephrine-POS, Adrianol.

The substance is also found in the combination Dimetindene + Phenylephrine in the drug Vibrocil.

Reviews of Phenylephrine

Reviews of medications based on Phenylephrine are good. Adverse reactions are rare, the drug quickly normalizes blood pressure. Parents respond especially well to nasal drops and sprays for children; the drug is quite effective, but only eliminates the symptoms of a runny nose.

Phenylephrine price, where to buy

The price of Phenylephrine in Irifrin eye drops 2.5% is approximately 370 rubles for one bottle of 5 ml.

You can buy Nazol Baby nasal drops (0.125% solution) for 160 rubles, 15 ml bottle.

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Lily: And if it’s a thorn, can you drip some drops?

Gray: Tablets are effective, I didn’t think that only tablets would help me restore my .

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/fenilefrin

Phenylephrine - instructions for use

Phenylephrine hydrochloride is a white crystalline powder with vasoconstrictor and adrenomimetic properties. In ophthalmology it is used in the form of drops under the trade names Irephrin, Neosynephrine, etc. It is prescribed for the treatment of iridocyclitis, diagnostic tests, and surgical operations.

Composition and release form

Phenylephrine hydrochloride is a white or slightly yellowish crystalline powder, easily soluble in alcohol and water.

Irifrin – solution of eye drops 2.5% or 10%. Contains 25 or 100 mg of phenylephrine hydrochloride, respectively. Available in 5 ml dropper bottles.

Neosynephrine-POS is a solution of eye drops 5% or 10%, containing 50 or 100 mg of phenylephrine hydrochloride, respectively. Available in 10 ml dropper bottles.

Pharmacological properties

Phenylephrine hydrochloride is a sympathomimetic with a direct effect on α-adrenergic receptors. Such properties lead to contraction of the muscles that dilate the pupil (mydriasis) and narrowing of the conjunctival arterioles. No cycloplegic effect was detected.

When instilled into the eye, the onset of its action occurs after a minute and continues: for a 2.5% solution - up to 2 hours, for a 10% solution - 3-7 hours. When applied topically, systemic absorption is minimal.

Indications for use

  • Iridocyclitis (to prevent the formation of posterior synechiae).
  • Glaucoma (relief of glaucomatous-cyclic crises).
  • Diagnostic examinations of the fundus, differential diagnosis of eyeball injection determination, provocative tests for glaucoma.
  • Preoperative preparation in ophthalmic surgery.

Directions for use and doses

For therapeutic purposes, for anterior uveitis or glaucoma-cyclic crises, solutions of drops with phenylephrine hydrochloride 5% are used three times a day, one drop (with atropine). After iridectomy, a 10% solution is prescribed 2-3 times daily, one drop.

For diagnostic purposes, solutions of drops with phenylephrine hydrochloride are used once or twice, 1-2 drops every 10 minutes or 1 hour. The mydriatic effect can last for more than 3 hours without the onset of cycloplegia.

For differential diagnosis of types of eyeball injection, use a 2.5% solution of phenylephrine once, one drop before the procedure.

When conducting a provocative test in case of suspicion of angle-closure glaucoma, a 2.5% or 5% solution of phenylephrine hydrochloride is instilled once.

To prepare for ophthalmic surgery, a solution of eye drops with phenylephrine is instilled a minute before the intervention in a dosage of 1-2 drops.

Contraindications

  • Individual hypersensitivity.
  • Arterial hypertension, coronary heart disease, intracardiac blockade and ventricular tachycardia, vascular aneurysms, arrhythmia.
  • Persistent long-term insulin-dependent diabetes mellitus, thyrotoxicosis, hepatic porphyria, erythropathies, closed-angle glaucoma (without previous iridectomy), narrow anterior chamber angle.
  • When taking MAO inhibitors, tricyclic antidepressants, drugs to lower blood pressure.
  • Additional pupil dilation during eye surgery.

Children under 12 years of age and elderly people are not prescribed 10% solutions of phenylephrine hydrochloride. In patients with diabetes mellitus, bronchial asthma, and cerebral atherosclerosis, drugs with phenylephrine are prescribed with caution; in pregnant women - only if absolutely necessary.

Side effects

Often there is passing pain, burning at the instillation site, blurred vision, photophobia, increased IOP, irritation of the conjunctiva, discomfort, transient keratitis, dermatitis and allergic conjunctivitis.

The next day after instillation of solutions with phenylephrine, reactive miosis is possible. Repeated use of the drug often weakens the mydriatic effect. After discontinuation of the drug, local hyperemia may develop.

Possible systemic manifestations: tachycardia, arrhythmia, palpitations, increased blood pressure, bradycardia, subarachnoid hemorrhage, syncope, headache.

When instilling a 10% phenylephrine solution, there is a risk of coronary artery spasm, ventricular arrhythmia and fatal myocardial infarction (extremely rare) in patients with heart and vascular diseases.

Overdose

An overdose of phenylephrine may cause anxiety and nervousness, sweating, dizziness, vomiting, shallow breathing, and tachycardia.

Toxic reactions develop quickly and have a short duration. Their treatment is usually supportive; if necessary, 2-5 mg of phentolamine is administered intravenously.

Drug interactions

The use of phenylephrine and atropine gives a greater mydriatic effect, but increases the risk of developing tachycardia.

Phenylephrine can block the action of drugs to lower blood pressure and cause a hypertensive crisis.

When using drugs with phenylephrine and MAO inhibitors together, the risk of adrenergic reactions increases. Incl. and 21 days after discontinuation of MAO inhibitors.

With simultaneous use of phenylephrine with cardiac glycosides, sympathomimetics, antidepressants, reserpine, beta-blockers, guanedine and methyldopa, the risk of developing severe arrhythmias seriously increases and remains for some time after their withdrawal.

special instructions

Before prescribing phenylephrine, it is imperative to assess the depth of the anterior chamber of the eye in order to prevent an acute attack of glaucoma.

To relieve pain in the eye during instillation of phenylephrine solution, it is recommended to pre-instill painkillers.

Instillation of phenylephrine significantly alters visual perception, so you should not drive or perform potentially dangerous activities.

Store eye drops at room temperature. Keep away from children.

Price of the drug Phenylephrine

Phenylephrine analogs

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We work for you seven days a week, seven days a week, from 9:00 to 21:00. Phone number for inquiries and appointments.

You can also use the ONLINE DOCTOR CONSULTATION and ONLINE RECORDING forms on the website.

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Refractive surgeon, specialist in laser vision correction (LASIK, Femto-LASIK) for myopia, farsightedness and astigmatism.

A retina specialist conducts diagnostics and laser treatment of retinal diseases (dystrophies, ruptures, hemorrhages).

Reviews

Phenylephrine is an active ingredient in various medications, the trade names of which may differ (for example, the “Irifrin” you mentioned in various concentrations).

Source: http://mgkl.ru/patient/aptechka/fenilefrin

Applications and analogues of Phenylephrine eye drops

Today, pharmacies offer a wide variety of medications, including eye drops. But you need to know that many drugs are far from universal in use and are recommended only in certain cases. These include Phenylephrine eye drops, a drug from the group of alpha-adrenergic agonists, which is used as a powerful vasoconstrictor. But what causes blood vessels in the eyes to burst and what products should be used is indicated in the article at the link.

Let's understand the intricacies of using these drops and consider the purpose for which they are prescribed, who can use them and who cannot.

Action of drops

The drug Phenylephrine is available both independently and as part of other eye medications.

Also, drug manufacturers supply it to the shelves of domestic pharmacies under other names:

  • Irifrin - 2.5% or 10% eye drops containing, respectively, 25 or 100 mg of the active substance - phenylephrine hydrochloride, produced in a soft transparent dropper bottle with a volume of 5 ml;
  • Neosynephrine-POS is the same drug for the eyes, only 5-10% in a 10 ml bottle, which corresponds to 50 and 100 mg of phenylephrine;
  • and Phenylephrine hydrochloride itself - in the form of a light crystalline powder that dissolves in liquid.

Phenylephrine is a good drug that both treats eye pathologies and helps ophthalmologists in diagnostic studies.

In the annotation for this drug you can study its properties in more detail.

Instructions for use

The pharmacological properties of Phenylephrine are reduced to the process of mydriasis - dilation of the pupils and narrowing of the muscles of the eyeball located next to them, as well as the arterioles of the conjunctiva. But how to treat chronic conjunctivitis and what can be done about such a problem is indicated here.

The action of the drops begins minutes after instillation into the eye. And it lasts differently: if 2.5% drops were dropped, then their pharmacological effect will last up to 2 hours, and if 10% drops were used, then from 3 to 7 hours.

By affecting the pupil and nearby tissues, phenylephrine can cause:

  • increased blood pressure in hypertensive patients, combined with reflex bradycardia;
  • increased resistance to blood flow in the vascular system, that is, circulatory disorders;
  • increased excitability, as it affects the central nervous system;
  • disruption of blood flow in internal organs and limbs.

The video shows how to use the drops correctly:

  • restores normal breathing by reducing swelling of the mucous membrane of the nasal passage;
  • helps reduce mucous discharge from the nose;
  • reduces the feeling of pressure in the sinuses and ears.

In addition, the drug is widely used in the diagnosis of ophthalmological diseases. In addition to dilating the pupil, by narrowing the conjunctival vessels, it provides increased outflow of intraocular fluid, which is necessary for doctors, for example, during surgery.

Indications for use

Eye drops with the active ingredient Phenylephrine are used or prescribed in the following cases:

  • during an ophthalmological examination that requires examination of the back of the eye;
  • to reduce fluid secretion and prevent the appearance of eye pathologies during iridocyclitis;
  • when you need to confirm or refute the diagnosis of “angle-closure glaucoma” using a provocation test. But how laser treatment of glaucoma occurs and what reviews there are, you can find out from the article at the link.
  • when preparing a patient for ophthalmic surgery, when it is necessary to significantly dilate the pupil. You can use eye drops to dilate your pupils.
  • when using laser and vitreoretinal therapy on the organ of vision;
  • for relief of Posner-Schlossman syndrome (glaucomocyclic crisis);
  • in combination with other drugs to treat inflamed whites, so-called red eyes.

The drug Phenylephrine can be used only as prescribed by an ophthalmologist.

Phenylephrine is also widely used for the treatment of ENT organs. In particular, to improve nasal breathing in case of specific allergic reactions, acute respiratory viral infections, which are accompanied by rhinitis and sinusitis. This substance is also applicable for hypotensive conditions, shock (resulting from exposure to various toxins or injuries), for local anesthesia and vascular insufficiency.

Contraindications

Like any other medicine, ophthalmic:

  • elderly patients with concomitant cardiovascular and cerebrovascular diseases;
  • in case of dysfunction of the lacrimal glands;
  • protrusion of arterial walls (aneurysm);
  • with a persistent lack of thyroid hormones (hypothyroidism);
  • liver porphyria;
  • deficiency of glucose-6-phosphate dehydrogenase;
  • during operations with violation of the integrity of the eyeball;
  • closed-angle and narrow-angle forms of glaucoma;
  • underweight children
  • and age up to 12 years.

Phenylephrine is absolutely contraindicated in newborns, children under 6 years of age and pregnant women!

Also, the drug is prohibited for use by hypertensive patients (but if you cannot do without it, then the use of Phenylephrine is allowed, but with strict control of blood pressure), with impaired cardiac function, in particular heart failure, strokes and circulatory disorders in the brain, as well as with atherosclerosis.

Side effects

Sometimes, after using phenylephrine drops, patients experience some reactions, both local and systemic.

Phenylephrine, unfortunately, has a huge list of side effects. It is especially dangerous for older people and those who have concomitant diseases such as cardiovascular pathologies.

Side effects can be expressed in profuse lacrimation, cloudiness in the eyes, the so-called fog, an unpleasant burning sensation, discomfort on the mucous membrane of the eye, increased pressure inside the eye, and a decrease in the effectiveness of the drug with subsequent instillations. This all relates to local reactions.

Systemic ones consist of pressure surges, which is absolutely unacceptable for hypertensive patients, tachycardia and other cardiac disorders, and is also fraught with unforeseen consequences, headaches, excessive agitation and irritability, tremors, symptoms of poisoning (nausea, vomiting and dizziness) and other unpleasant phenomena. But here is a list of eye diseases in humans that can cause pain. You can see and read the information here.

In some cases, older people may even develop a heart attack.

Similar symptoms can occur with an overdose of the drug. Therefore, if you feel severely unwell after prolonged or uncontrolled use of phenylephrine, you should seek medical help.

Use for children

Phenylephrine is generally not prescribed at all in infancy. But its use in pediatrics is possible: in some cases, the use of this drug is allowed only in a 2.5% solution and starting from the age of six.

And by the way, if the child does not have allergic reactions. After the child reaches 12 years of age, phenylephrine can be used in small doses, literally a drop at night, of a ten percent solution.

Due to the large number of contraindications, the drug is usually prescribed to children and adolescents with extreme caution!

Use during pregnancy

Expectant mothers are also not recommended to use this drug. Given the range of possible side effects, this drug is used for pregnant women only in very extreme cases - when the benefit to the mother outweighs the risk to the intrauterine development of the fetus.

Price in pharmacies

Since this medication is available not only in the form of drops, but also in other dosage forms, the price for the active substance phenylephrine varies accordingly. But the cost of drugs containing it and their analogues under other trade names in pharmacies does not exceed five hundred rubles. The price varies depending on the manufacturer and supplier markups.

Analogs

This powdery substance, widely used in ophthalmology, is today included in many similar preparations, which differ from each other only in the name of the manufacturer, trade name and price. In domestic pharmacies, the most famous and widespread phenylephrine-containing eye medications of the same type are:

But in any case, they or phenylephrine in its pure form should be used as prescribed by a doctor. It is your attending physician who will be able to select an effective drug and determine whether it can be used for you.

Usually, unforeseen complications caused by the drug appear during self-medication, when the dosage is selected independently. In other situations, negative manifestations are due to the characteristics of the body.

Having studied your anamnesis and seeing the clinical picture, he will determine the combination of this drug with other medications. Indeed, by itself and in combination with other drugs, Phenylephrine can lead to very serious and life-threatening consequences. The presence of side effects of the drug may generally serve as a reason for its discontinuation.

Reviews

  • Marina: “Good drops! They were recommended to me by my attending physician when I, being myopic, complained to him about rapid eye fatigue and constant tension in them. I used them for some time: I put a drop in each eye before bed for three weeks. And amazingly, within a few days I felt extraordinary relief. My eyes stopped watering from fatigue, the stinging sensation stopped, and the whites of my eyeballs stopped turning red. So I’m happy!”
  • Dmitry: “Before, when my eyes were very inflamed, nothing helped me, but now - voila - my eyes no longer hurt, the symptoms of fatigue disappear in just a few days. It’s just a pity that you can’t use them all the time, but I recommend it!”
  • Svetlana: “I have been using this medicine for more than three months, albeit intermittently: the doctor says that they cannot be used all the time. But, thanks to him, my eyes began to see well again and did not look tired or inflamed. Great eye drops!”

Phenylephrine is a drug widely used by ophthalmologists today. They use it during examination during the diagnosis of diseases to dilate the pupils, in particular to determine glaucoma and some other eye diseases. This drug from the group of alpha-adrenergic agonists is prescribed only by an ophthalmologist after a detailed examination.

Source: http://okulist.online/zabolevaniya/lechenie/medikamenozonoe/kapli/fenilefrin-glaznye.html

Phenylephrine hydrochloride Phenylephrine

Trade name of the drug

International nonproprietary or chemical name

Prices in pharmacies

The table below presents data from many pharmacies at once. Prices are updated automatically daily. You can choose the most advantageous offer. When you click on the picture or the name of the drug, the pharmacy’s website will open in a new window.

Polydexa with phenylephrine

Bouchara E. Lab., France

Release form

substance-powder 1 kg|

, laminated aluminum foil bags - 1

Pharmacotherapeutic group

Country of origin

Legal entity in whose name the registration certificate was issued

Cheng Fong Chemical Co.Ltd

Registration certificate

Analogues, similar drugs

, laminated aluminum foil bags - 1

Source: http://healthguide.spb.ru/medorg/drugs/%D0%A4/15233-fenilefrina-gidrochlorid.html

Ophthalmologist Assistant - Phenylephrine

Sometimes there is a need for diagnostic and surgical procedures on the organs of vision.

In order for the doctor to correctly assess the condition of the eye and fundus, the pupil must be enlarged.

It is for these purposes that special ophthalmic drops called Phenylephrine are used.

In addition, they are used to treat certain eye diseases. We have placed reviews of the drops at the end of the article.

Instructions for use

Indications

There are a huge number of indications for which Phenylephrine is prescribed. These include both diseases and diagnostic and therapeutic interventions.

Here are the most basic of them:

  • performing ophthalmoscopy;
  • provocation for diagnosing glaucoma;
  • surgical interventions;
  • laser microsurgery;
  • superficial and deep dilatation of the blood vessels of the eye;
  • inflammation of the iris and ciliary body;
  • false myopia;
  • Posner-Schlossman syndrome.

The video shows how ophthalmoscopy is performed:

Directions for use and dosage

The drug is used by instillation into the conjunctival sac. It is recommended to avoid touching the bottle with the dropper to various surfaces, as this leads to its contamination and there is a risk of eye infection.

The dosage of the drug depends on the indications for which it is prescribed.

If it is necessary to dilate the pupil, instill one drop of Phenylephrine. The maximum effect is achieved half an hour after instillation and remains so for 90 minutes.

For the treatment of false myopia, the drug is prescribed 1 drop per day.

To conduct provocative tests in patients with suspected glaucoma, the drug is used 1 drop once.

When treating Posner-Schlossman syndrome, Phenylephrine is instilled three times a day at equal intervals.

For inflammation of the iris and ciliary body, the drug is prescribed 2 times a day, one drop.

Release form and composition

Phenylephrine belongs to the group of alrenomimetics and mydriatics. When used topically, it has a pronounced vasoconstrictor, mydriatic and hypotonic effect.

Pheniephrine can also have a systemic effect: it constricts arterioles and has a hypertensive effect

  • benzalkonium chloride;
  • lemon acid;
  • sodium dihydrate;
  • distilled water.

Drug interactions

The combined use of Phenylephrine and atropine potentiates the effect of atropine. An increased heart rate is also likely.

The simultaneous use of phenylephrine and monoamine oxidase inhibitors leads to the development of malignant arterial hypertension.

Beta blockers in combination with phenylephrine can also cause an uncontrolled increase in blood pressure to extremely high levels.

Drugs used for general anesthesia can cause depression of the cardiovascular system if Pheniephrine was used 72 hours before anesthesia.

Side effects

When using Phenylephrine, unwanted reactions often develop. Most of them are transient, but monitoring by an ophthalmologist is necessary.

Most often, the organs of vision react to instillation of Phenylephrine. Possible:

In some cases, systemic side effects are possible.

From the heart and blood vessels the following may occur:

  • cardiopalmus;
  • arrhythmia;
  • extrasystoles;
  • bradycardia;
  • heart attack;
  • acute cerebrovascular accident;
  • pulmonary embolism.

Skin reactions in the form of itching, urticaria, erythema, and Quincke's edema are also possible.

Contraindications

Phenylephrine is contraindicated in the following conditions:

  • violation of the integrity of the eye;
  • old age (over 75 years);
  • diseases of the thyroid gland with hyperfunction;
  • age up to 6 years;
  • intolerance to any component of the drug;
  • porphyria;
  • aneurysm.

Relative contraindications requiring close medical supervision:

  • renal dysfunction;
  • liver dysfunction;
  • sickle cell anemia;
  • long-term use of contact lenses.

During pregnancy

No special studies have been conducted on the effects of Phenylephrine on pregnant women and the fetus. It is not known whether Phenylephrine can cross the placenta and be found in breast milk.

The use of Pheniephrine during pregnancy and lactation is possible only with the permission of a doctor.

Storage conditions and periods

The product is stored in a dark place at room temperature. Freezing Phenylephrine is unacceptable.

The shelf life of the drug is 24 months. After opening the bottle, the medicine must be used within 30 days.

Average price in Russia

One bottle of Phenylephrine costs about 400 rubles. The minimum price is 350 rubles, and the maximum is 450.

Average price in Ukraine

Phenylephrine is not sold in Ukraine, but you can buy the following analogues:

  1. Mezaton (price – 35 hryvnia),
  2. Neosinephren-Pos (price – 257 hryvnia),
  3. Irifrin (price – 400 hryvnia).

Reviews

Patients who have left reviews of Phenylephrine online claim that it does its job well.

The relatively high cost and discomfort after instillation are the main disadvantages mentioned by patients.

conclusions

  1. Phenylephrine is an ophthalmic agent used for a wide range of conditions.
  2. Phenylephrine belongs to the group of adrenomimetics and mydriatics.
  3. Sometimes unwanted side effects occur when using Phenylephrine.
  4. Phenylephrine should only be used as prescribed by a doctor.

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Source: http://moezrenie.com/lechenie/kapli-dlya-glaz/pomoshchnik-oftalmologa-fenilefrin.html

Phenylephrine

About the drug:

Phenylephrine belongs to the group of selective α-adrenergic agonists, with a predominant effect on α1-adrenergic receptors.

Indications and dosage:

  • Русский
  • To carry out diagnostic manipulations: ensuring mydriasis during ophthalmoscopy, conducting provocative tests if angle-closure glaucoma is suspected, as well as in persons with a narrow profile of the anterior chamber of the eye;
  • Preoperative preparation: pupil dilation for surgical interventions and laser operations on the fundus;
  • Differentiating between superficial and deep injection of the eyeball;
  • Treatment of iridocyclitis, red eye syndrome, glaucomatous-cyclic crises, treatment of spasm of accommodation and true myopia in people with high visual load.

To achieve a sufficient pharmacological effect, a single use of the drug is sufficient. Ophthalmoscopy: one-time instillation of 2.5% Phenylephrine solution locally (into the conjunctival sac); instillation may be repeated after 60 minutes in case of insufficient drug-induced mydriasis. Carrying out diagnostic procedures: to conduct a provocative test, a single instillation of one drop of 2.5% solution. If there is a difference in intraocular pressure from three to five mm Hg. Art. the provocative test is positive. In the case of differentiation of superficial and deep injection of the eyeball, 1 drop is instilled once and the results are assessed after five minutes. When the conjunctival vessels are narrowed, the injection is considered superficial; if hyperemia persists, this is a sign of dilatation of deep-lying vessels. Treatment of iridocyclitis (2.5%, 10% solution) and glaucomatous-cyclic crisis (10% solution): instillation of one drop of Phenylephrine with an interval of 8 hours, course of treatment up to 10 days depending on the severity of the disorders. For mild myopia and spasm of accommodation during periods of high visual stress, Phenylephrine 2.5% is prescribed, one drop before bedtime. As myopia progresses, take 1 drop of Phenylephrine three times a day. Preoperative preparation: 10% Irifrin solution is instilled once into the conjunctival sac half an hour before surgery. After opening the eye membranes, repeated instillations are not performed.

Overdose:

Symptoms of overdose: anxiety, nervousness, sweating, dizziness, vomiting, increased heart rate, shallow and weak breathing. To relieve the negative effects of overdose, alpha adrenergic receptor blockers are prescribed - phentolamine 5-10 mg intravenously.

Side effects:

Local side effects: inflammation and incoming redness of the conjunctiva, keratitis, swelling and pain in the eye, burning, lacrimation after instillation, increased intraocular pressure. It is possible to develop reactive constriction of the pupil a day after instillation, which reduces the effectiveness of repeated instillations, which is more typical for older people. As a result of a significant contraction of the pupil dilator, after half an hour, particles of pigment from the cells of the pigment layer of the iris appear in the moisture of the anterior chamber of the eye. And it requires differentiation with uveitis or with the penetration of blood cells.

Contraindications:

  • Русский
  • Individual hypersensitivity to the drug or drug components.
  • Narrow-angle or closed-angle glaucoma.
  • Diseases of the cardiovascular system with cardiac arrhythmia, tachycardia, increased blood pressure, aortic aneurysm.
  • Additional mydriasis during operations with a violation of the integrity of the tissues of the eyeball or a decrease in overall tear production.
  • Diabetes mellitus type 1.
  • Disease of the thyroid gland with overproduction of hormones.
  • Lack of glucose-6-phosphate dehydrogenase.
  • Hepatic porphyria.
  • Breastfeeding period.
  • Childhood.

Not recommended for use during pregnancy and lactation. The drug causes retardation of fetal development and stimulates early labor.

Interaction with other drugs and alcohol:

Atropine enhances the mydriatic effect of phenylephrine with a parallel development of an increase in heart rate. Monoamine oxidase inhibitors and tricyclic antidepressants while using phenylephrine increase the risk of developing uncontrolled arterial hypertension. The appearance of this effect can be avoided by not prescribing Phenylephrine for 3 weeks after discontinuation of MAO inhibitors. The vasopressor effects of phenylephrine are enhanced by propranolol, reserpine, guanethidine, m-anticholinergic agents and methyldopa. Beta-blockers, when combined with Phenylephrine, weaken their hypotensive effect, which is dangerous by the development of a hypertensive crisis. Phenylephrine enhances the inhibitory effect on the cardiovascular system during inhalation anesthesia. Local anesthetics increase the duration of mydriasis.

Composition and properties:

In 1 ml - phenylephrine hydrochloride 25 mg

Excipients: sodium citrate dihydrate, disodium edetate, citric acid, hypromellose, sodium metabisulfite, water for injection.

In 1 ml - phenylephrine hydrochloride 100 mg

Excipients: sodium hydroxide, sodium hydrogen phosphate dihydrate, sodium citrate dihydrate, sodium dihydrogen phosphate anhydrous, disodium edetate, sodium metabisulfite, citric acid, benzalkonium chloride, water for injection.

Eye drops without preservative.

  • Eye drops 2.5% 5 ml – plastic dropper bottles. 1 fl. in a cardboard pack.
  • Eye drops 2.5% - 0.4 ml in disposable dropper tubes. 5 tubes in a laminated paper bag. 3 packets per cardboard pack.
  • Eye drops 10% 5 ml – fl. dark glass complete with a dropper - 1 bottle in a cardboard box.

Mydriatic action. Causes stimulation of a1-adrenergic receptors, which are localized in the postsynaptic membranes of blood vessels and the radial muscle of the iris, as the point of application for this drug. Dilates the pupil without affecting accommodation and improves intraocular pressure. Affects the development of peripheral vasoconstriction of arterioles and initiates narrowing of arterioles of the conjunctiva of the eye.

Store in a dry, dark place at a temperature not exceeding 25 degrees Celsius. After opening the bottle, store for 1 month.

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The information published on the site is for informational purposes only. Described methods of diagnosis, treatment, traditional medicine recipes, etc. It is not recommended to use it yourself. Be sure to consult a specialist so as not to harm your health!

Source: http://www.likar.info/lekarstva/Fenilefrin/

Phenylephrine Hydrochloride eye drops - instructions. Good vasoconstrictor and mydriatic agent

Phenylephrine eye drops (phenylephrine hydrochloride) is a vasoconstrictor and mydriatic agent.

This drug can be prescribed for the treatment of ophthalmological diseases, and is also instilled before diagnostics and eye surgery.

Phenylephrine Hydrochloride eye drops: general information and instructions for use

Phenylephrine belongs to the group of alpha-adrenergic agonists. Drugs in this group promote vasoconstriction.

This medicine in the form of eye drops is used as a topical agent.

The effect of using such drops occurs within a period of twenty minutes to half an hour after instillation and lasts on average for five hours.

After this time, the drug enters the kidneys and is excreted in the form of metabolites.

pharmachologic effect

Phenylephrine has a stimulating effect on the alpha-adrenergic receptors of the eyes, resulting in the following effects:

  • the peripheral resistance of the capillaries of the vessels of the eye increases and blood pressure rises;
  • the pupil enlarges;
  • the vascular network of the conjunctival membrane narrows, which leads to increased outflow of intraocular fluid.

Mode of application

There are two types of phenylephrine hydrochloride drops - 2.5% and 10% solutions.

The effect of the first lasts for the next two hours, and the effect of the second lasts from three to seven hours.

According to the instructions for use, the product is instilled into the conjunctival sac of each eye, two to three drops.

Indications

The product is used in the following cases:

  • conducting a provocative test if angle-closure glaucoma is suspected;
  • in the treatment of iridocyclitis - to prevent the formation of areas of tissue fusion (synechia);
  • as a pupil dilator before diagnostics or operations;
  • before vitreoretinal and laser operations.

The drug can also be an additional agent in the treatment regimen for “red eye” syndrome, which occurs in many ophthalmological diseases.

Interaction with other drugs

  1. Combined use with atropine increases the effectiveness of the drugs, but the development of tachycardia is possible.
  2. Simultaneous use with antidepressants can lead to the development of a hypertensive crisis.
  3. The effectiveness of antihypertensive drugs decreases with instillation of phenylephrine.
  4. In the case of joint instillation with monoamine oxidase inhibitors (MAOIs), adrenergic reactions may develop (increased levels of adrenaline production).

In patients using beta-blockers, antidepressants, sympathomimetics and cardiac glycosides in parallel with phenylephrine, the risk of developing arrhythmia increases.

Side effects

After instillation of such eye drops, the following adverse reactions may occur:

Due to the interaction with the central nervous system of the active components of the drops, a state of increased excitability may develop.

Contraindications

  • closed-angle glaucoma;
  • hypothyroidism;
  • narrow-angle glaucoma;
  • hepatic porphyria;
  • disorders of the tear fluid production system;
  • arterial aneurysm;
  • cardiovascular and cerebrovascular disorders in elderly patients.

The drug is not prescribed to children under 12 years of age, and during pregnancy, phenylephrine is used with caution and under the supervision of a physician.

Composition and features of release from pharmacies

In pharmacies, the drug can be sold under different trade names (appamide plus, neosynephrine-POS, irifrin).

In fact, although these products are considered analogues, they are identical in composition to drops, which include the following components:

  • water for injections;
  • sodium citrate dihydrate;
  • hypromellose;
  • disodium edetate;
  • benzalkonium chloride;
  • sodium dihydrogen phosphate;
  • sodium hydrogen phosphate dihydrate.

Storage conditions and periods

The product in an unopened bottle can be stored at temperatures up to +25 degrees for twelve months. The opened container can be stored under the same conditions for no longer than one month.

Analogs

  1. Visofrine.

A solution that has a direct effect on alpha-adrenergic receptors.

When applied, it causes constriction of blood vessels and leads to dilation of the pupils.

For open-angle glaucoma, the drug lowers intraocular pressure.

  • Irifrin.

    An almost complete analogue of phenylephrine, which has a vasoconstrictor effect and does not have any effect on the nervous system, provided the dosage is observed.

  • Mezaton.

    A vasoconstrictor mydriatic drug, which has a longer but less pronounced effect.

    Recommended for use by patients with problems with the cardiovascular system, as it does not have a negative effect on the functioning of the heart.

  • Mydriacyl.

    A drug that provokes the occurrence of paralysis of accommodation, thereby achieving a mydriatic effect.

    It is possible to use the solution not only before operations and diagnostics, but also as therapeutic drops and a prophylactic agent.

    At the same time, the solution helps reduce the rehabilitation period after eye surgery.

  • Tropicamide.

    One of the common mydriatics that causes pupil dilation.

    When used, a slight increase in intraocular pressure is sometimes observed.

    The mydriatic effect of the drops appears a few minutes after instillation and lasts for an average of an hour.

    • Cost of the drug

    Under the name “phenylephrine” the drug is sold at an average price of 415 rubles. In the form of neosynephrine POS drops in Russian pharmacies cost up to 450 rubles per bottle.

    Additional recommendations for use

    Since this drug, characterized by a high level of absorption through the conjunctival membrane into the systemic circulation, can contribute to the development of systemic side effects.

    If the patient requires treatment with MAO inhibitors, phenylephrine can be used only three weeks after treatment with such drugs.

    Before prescribing such drops, the patient must be examined for heart problems and hypertension.

    In some cases, the use of the product on a damaged cornea can lead to opacification.

    Therefore, in such situations, treatment is carried out under the supervision of a doctor and is immediately canceled at the first signs of the development of such a pathology.

    Reviews

    “I was advised by my ophthalmologist to take phenylephrine drops as a treatment for tired eyes, and although this drug is intended for other purposes, it worked perfectly for me in this capacity.

    These drops relieve irritation and fatigue well, but using them for a long time is harmful to the organs of vision.

    So after a few weeks I had to switch to less effective but safe medications.”

    Marina Prokofieva, Moscow.

    “I used phenylephrine hydrochloride as prescribed by a doctor after laser correction of myopia.

    The only unpleasant thing was that after instilling the product, the clarity of vision was lost for some time.

    But for me this was not critical, since during the rehabilitation period I was on sick leave and such temporary deterioration in vision generally did not interfere.”

    Evgeny Avdonin, Gelendzhik.

    Useful video

    This video shows how to properly instill eye drops:

    Phenylephrine hydrochloride is a specific drug that is available in pharmacies only with a prescription.

    It is not recommended to use such drops without the approval of a doctor, but even if the use of such a drug is approved by a specialist, it is necessary to make sure that the patient has no contraindications to the drug.

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    1 COMMENT

    I tried a lot of medications that help with tired redness of the eyes. Few things have been as effective as this drug. I just put 1 drop in each eye in the evening before bed for two weeks and that’s it. The result was obvious already on the 3-4th day. These drops cannot be used continuously, only intermittently.

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