Coldact dosage

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Coldact Flu Plus

Description current as of 06/04/2014

  • Latin name: Coldact Flu Plus
  • ATX code: N02BE51
  • Active ingredient: Paracetamol + Phenylephrine + Chlorphenamine (Paracetamol + Phenylephrine + Chlorphenamine)
  • Manufacturer: Natco Pharma (India)

Composition of Koldakt

The composition of the drug Koldakt includes the active ingredients phenylpropanolamine hydrochloride - 0.5 g + chlorpheniramine maleate - 0.08 g and additional substances that make up the gelatin shell.

Table of contents:

Coldact Flu Plus contains capsules of active ingredients: paracetamol – 0.2 g; chlorphenamine maleate – 8 mg; phenylephrine hydrochloride – 25 mg and excipients (hypromellose, MCC, talc, ethylcellulose, povidone, diethyl phthalate, isopropanol, dyes, sucrose, water, sodium disulfite, starch syrup, disodium edetate, granulated sugar).

Flu Plus suspension contains active ingredients: chlorphenamine maleate – 2 mg; paracetamol – 0.125 g; phenylephrine hydrochloride - 5 mg + sodium carmellose, propyl parahydroxybenzoate, disodium edetate, methyl parahydroxybenzoate, sodium saccharinate, sodium chloride, MCC, glycerin, sucrose, xanthan gum, silicon dioxide, flavorings, polysorbate 20, sodium citrate, water, citric acid.

Release form

Koldakt is produced in long-acting capsules in a gelatin shell, packs of 10 pieces.

Coldact Flu Plus - in two forms:

  • capsules in a gelatin shell, half red, half transparent, inside - yellow, red and white pellets, in packs of pieces;
  • suspension for internal use, viscous, orange, with a specific odor, in a 60 ml bottle.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

Chlorpheniramine, which is part of the Coldact and Coldact Plus tablets, is the most effective antihistamine that reduces the effect on H1 receptors. It also has a slight sedative and antimuscarinic effect. The substance has the ability to reduce the permeability of mucosal cells in the nose, thereby reducing unpleasant symptoms (itching and swelling).

The process of interaction with blood plasma occurs slowly. The maximum concentration is after 2-6 hours, metabolized in the body. However, a small part of it is excreted by the kidneys.

Another active ingredient, phenylpropanolamine, is a symptomatomimetic. It affects alpha-adrenergic receptors, but to a lesser extent than, for example, ephedrine. It has a vasoconstrictor, anti-edematous effect on the mucous membrane of the nose and paranasal sinuses.

Reaches maximum concentration within 2 hours. Excretion is carried out through the kidneys.

Paracetamol reduces body temperature and relieves pain. Helps eliminate cold symptoms - headaches, pain in joints and muscles, discomfort in the throat.

It binds poorly to blood proteins, less than 10%, is metabolized in the liver, maximum concentration is after 3 hours. Excretion occurs in the urine within 24 hours after administration.

Indications for use

  • rhinitis (vasomotor or allergic);
  • elimination of cold symptoms such as allergies, swelling, runny nose, stuffy nose.

Contraindications

Taking the drug in capsules is not recommended for children under 12 years of age if they have a drug allergy to any of the components.

The suspension can be taken by children from 6 years of age.

Flu Plus has a number of additional contraindications:

Side effects

Doesn't happen often:

Instructions for Koldakt (Method and dosage)

The duration of administration and dosage should be prescribed by a doctor.

According to the instructions for use of Koldakt, adults are prescribed 2 capsules per day, divided into 2 doses.

Instructions for use Coldact Flu Plus

According to the instructions for Coldact Flu Plus, two capsules are prescribed per day, at regular intervals.

The syrup should be shaken well before use.

Adults are prescribed poml per day, in 3-4 doses. Children from six years old – ml, in 3-4 doses.

The course of treatment, as a rule, is no more than five days.

Overdose

No cases have been reported. Therapy - according to symptoms.

For the form that contains paracetamol, the symptoms are: nausea, hepatonecrosis, pallor and weakness, loss of appetite. Consult a doctor as soon as possible and rinse the stomach, administer SH-group donors, methionine (first 8 hours) or N-acetylcysteine ​​(12 hours).

Interaction

Use with caution in combination with MAO inhibitors, tricyclic antidepressants, halothane, guanethidine, furazolidone.

Terms of sale

Storage conditions

Dry, cool place.

Best before date

Coldact Flu Plus – 2 years.

Analogs

During pregnancy and lactation

Reviews about Koldakt

There are not many reviews about Koldakt. But of those that exist, the positive ones predominate. Colds and flu are easier to bear with the drug; runny nose and other unpleasant symptoms go away faster. The most common side effect is drowsiness.

Reviews of Koldakt Flu Plus are good. The drug quickly reduces fever, relieves nasal congestion, and is relatively inexpensive. In reviews of Koldakt Flu Plus, side effects, mainly drowsiness, are considered a disadvantage.

Koldakt price (where to buy)

The approximate price of Koldakt is about 98 rubles for 10 pieces.

Price Coldact Flu Plus for 10 capsules rubles.

The price of Coldact Flu Plus syrup is 100 rubles.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Kazakhstan Kazakhstan

ZdravZone

Pharmacy IFC

BIOSPHERE

jreview excellent product. I have one question - I was prescribed this drug along with another drug that I forgot, you can’t tell me. The fact is that when used together, the effect was stunning.

Ivan: We’ve been working for more than half a year. They have proven themselves. Everything is guaranteed. In stock.

Yulia: I have the same symptoms, I thought it was meningitis. I almost didn’t say goodbye at all. Head.

Diets.Guru: If the stage of the disease and the patient’s condition allow the possibility of surgery.

Kostya: Yesterday I picked up the child from kindergarten, came home and then it all started! At first the boy complained.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/koldakt-flyu-plyus

Coldact

Instructions for use:

Price in online pharmacies:

The drug Koldakt is a long-acting combined anti-cold drug with a pronounced anticongestive, antihistamine and vasoconstrictor effect.

The mechanism of action of Koldakt and Koldakt Plus is determined by the components included in its composition. This drug is not intended to eliminate the underlying cause of the disease, but effectively eliminates the main symptoms of viral inflammation of the respiratory tract.

The combination of this symptomatic remedy with antibiotics and expectorants will speed up the healing process and prevent the development of bacterial complications.

Release form

The following dosage forms of the drug are available: long-acting capsules, tablets, powders for solution, suspension.

Koldakt capsules contain two active ingredients - phenylpropanolamine hydrochloride (50 mg) and chlorphenylaraine maleate (8 mg).

Chlorphenylaramine is one of the most powerful histamine H1 receptor blockers. It has a moderate antimuscarinic and sedative effect.

An indirect action symptom mimetic, phenylpropanolamine, is used to eliminate congestion in the mucous membrane of the respiratory tract. According to the mechanism of action, this substance is similar to ephedrine, but has less effect on the central nervous system.

Coldact Flu Plus capsules contain three active components - chlorphenamine maleate (8 mg), paracetamol (200 mg) and phenylephrine hydrochloride (25 mg), and excipients - ethylcellulose, talc, sucrose, starch, sodium disulfite.

The uniqueness of Coldact Flu Plus capsules lies in the fact that each drug in the form of granules dissolves in the intestines gradually and the effect of the medicinal substance is extended up to 24 hours.

pharmachologic effect

The drug has a stimulating effect on alpha-adrenergic receptors, has a vasoconstrictor effect, reduces hyperemia and swelling of the mucous membrane of the paranasal sinuses and respiratory tract. Coldact Flu Plus actively blocks histamine receptors, which prevents the development of allergic reactions, reduces the permeability of blood vessels in the mucous membrane, eliminates itching in the nose and eyes, and eliminates lacrimation.

Paracetamol, acting on the thermoregulation center in the hypothalamus, has a pronounced antipyretic effect and eliminates pain.

When taken orally, the drug is absorbed relatively slowly from the intestine, with maximum plasma concentrations achieved 1-2 hours after oral administration. Widely distributed in the body, metabolized and excreted in urine almost unchanged.

Indications

The instructions for Koldakt recommend prescribing the drug for the symptomatic treatment of various colds, which are accompanied by swelling of the mucous membrane of the respiratory tract, lacrimation, runny nose, and sore throat.

The use of Koldakt is indicated for colds, which are characterized by allergization of the body, as well as for sinusitis, ARVI, and influenza.

Reviews of Koldakt confirm that it is extremely effective for the treatment of allergic and vasomotor rhinitis.

Coldact Flu Plus is indicated for use to eliminate symptoms of inflammation in the following respiratory tract diseases - tracheitis, pharyngitis, rhinitis, sinusitis, sinusitis. The drug also significantly reduces the severity of clinical manifestations of hay fever, allergic rhinitis, various colds, and flu.

Instructions for use (method and dosage)

Coldact and Coldact Flu Plus are prescribed to adults and children over 12 years of age, 1 capsule every 12 hours.

In complex therapy for influenza and ARVI, the drug is used for 1-3 days; for the treatment of sinusitis, Coldact Plus must be taken for 6-12 days. For allergic rhinitis, the drug is recommended to be used for 3-6 days, and for the treatment of chronic rhinitis for a month.

Coldakt Plus is prescribed as an antipyretic for no longer than 3 days. To relieve pain, the drug should be used for no more than 5 days. Numerous reviews of Koldakt indicate that the drug effectively eliminates pain in the throat, joints, muscles, and headaches.

Koldakt Broncho syrup is prescribed to children for colds that are accompanied by a cough with hard-to-clear sputum for five days in the following dosages:

  • children from 2 to five years old, 5 ml per day;
  • from 6 to 12 years, 10 ml/day;
  • over 12 years old and adults – 20 ml/day.

Contraindications

The instructions for Koldakt prohibit prescribing the drug to people with individual intolerance to any component in its composition. Also, the drug is not prescribed to patients with pheochromocytoma, thyrotoxicosis, closed-angle glaucoma, or prostatic hyperplasia. It is strictly prohibited to use the drug in children under one year of age and in patients with severe hypertension or coronary artery disease.

Koldakt should not be taken if you have arterial hypertension, diabetes mellitus or chronic heart failure.

Use during pregnancy and breastfeeding

The use of Koldakt by pregnant women and during lactation is not recommended.

special instructions

Children under 12 years of age are prohibited from prescribing the drug in capsule form; the use of suspension, powder and syrup is indicated.

Coldact Plus is also prohibited from being prescribed to patients with severe atherosclerosis of the coronary arteries, recent myocardial infarction, aortic aneurysm, unstable angina, as well as people taking MAO inhibitors or tricyclic antidepressants.

Reviews of Koldakt from specialists and patients are positive and confirm that the drug is well tolerated. In very rare cases, the following side effects have been reported:

  • dry mucous membranes;
  • dyspepsia;
  • allergic reactions;
  • cardialgia, increased blood pressure;
  • loss of appetite, nausea, vomiting;
  • tremor, headache.

During treatment, care should be taken when driving a vehicle, since the drug has a mild sedative effect and reduces concentration and reaction time.

Overdose

Long-term use of high doses of Coldact can lead to liver and kidney damage. Consumption of more than 15 g of the drug per day can lead to acute poisoning of the body. Symptoms of overdose are pale skin, nausea, vomiting, liver failure. If such clinical manifestations occur, it is necessary to rinse the stomach; treatment is symptomatic.

Storage conditions and shelf life

Koldakt must be stored at room temperature, out of reach of children, in a cool, dry place. The shelf life of the drug is 3 years from the date of production.

The description posted on this page is a simplified version of the official version of the annotation for the drug. The information is provided for informational purposes only and does not constitute a guide for self-medication. Before using the medicine, you must consult a specialist and read the instructions approved by the manufacturer.

Coldact flu plus No. 10 capsules

Coldact flu plus caps N10

When using materials from the site, the active reference is obligatory.

The information presented on our website should not be used for self-diagnosis and treatment and cannot serve as a substitute for consultation with a doctor. We warn you about the presence of contraindications. Specialist consultation is required.

Source: http://dolgojit.net/koldakt.php

Coldact® Flu Plus - official instructions for use

Trade name of the drug: Coldact ® Flu Plus

International nonproprietary name or generic name paracetamol + phenylephrine + chlorphenamine

Extended release capsules

Compound

Each capsule contains:

Chlorphenamine maleate 8 mg

Paracetamol 200 mg

Phenylephrine hydrochloride 25 mg

Excipients: talc 68.25 mg, hypromellose 4.5 mg, ethylcellulose 29 mg, diethyl phthalate 5.8 mg, microcrystalline cellulose 28.01 mg, povidone (PVP K 30) 6.41 mg, sodium disulfite 0.16 mg, disodium edetate 0.32 mg, crimson dye (Ponceau 4R) 0.35 mg, sunset yellow dye 0.01 mg, quinoline yellow dye 0.08 mg, Non Pareil Seeds 18/22 granules (sugar granules: sucrose, starch molasses) 124.11 mg.

Capsule shell: gelatin qs up to 100%, purified water 14‒15%, methyl parahydroxybenzoate 0.8%, propyl parahydroxybenzoate 0.2%, azorubine dye 0.35%, crimson dye (Ponceau 4R) 0.47%.

Description

Hard gelatin capsules with a red cap and a transparent body, size “0”, containing white or almost white, yellow and orange to red pellets.

Pharmacotherapeutic group

Acute respiratory infections and “cold” symptoms are eliminated (non-narcotic analgesic + alpha-adrenergic agonist + H1-histamine receptor blocker).

Pharmacological properties

Combined drug with prolonged action.

Paracetamol has analgesic and antipyretic effects.

Phenylephrine hydrochloride is an alpha adrenomimetic and has a vasoconstrictor effect, reduces swelling and hyperemia of the nasal mucosa and paranasal sinuses.

Chlorphenamine maleate - a blocker of H1-histamine receptors - has an antiallergic effect, reduces the severity of local exudative manifestations, eliminates lacrimation, itching in the eyes and nose.

Indications for use

Symptomatic treatment of ARVI, including influenza and “colds”, accompanied by high fever, chills, headache and muscle pain, runny nose and nasal congestion, sore throat, body aches, sneezing.

Contraindications

Hypersensitivity to any of the components included in the composition.

Taking monoamine oxidase inhibitors (MAO) (simultaneously or in the previous 14 days), simultaneous use of tricyclic antidepressants, beta-blockers or other sympathomimetic drugs.

Severe cardiovascular diseases, severe atherosclerosis of the coronary arteries, arterial hypertension, hyperthyroidism, diabetes mellitus, thyrotoxicosis, angle-closure glaucoma, pheochromocytoma, deficiency of the enzyme glucose-6-phosphate dehydrogenase. Severe diseases of the liver, kidneys, bladder, peptic ulcer of the stomach and duodenum, diseases of the pancreas, difficulty urinating with prostate adenoma, diseases of the blood system.

Pregnancy, breastfeeding period.

Children's age up to 12 years.

Carefully

Congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), bronchial asthma and chronic obstructive pulmonary disease, viral hepatitis. Should be taken with caution in patients with alcohol dependence.

There is a risk of liver damage in patients with glutathione deficiency (eg, fasting).

Use during pregnancy and breastfeeding

Coldact ® Flu Plus capsules are not recommended for use during pregnancy and breastfeeding.

Directions for use and doses

Orally, adults and children over 12 years old, 1 capsule every 12 hours for 3-5 days. Duration of use as an antipyretic is no more than 3 days; as a pain reliever – no more than 5 days.

If there is no sufficient therapeutic effect, there is a high temperature that persists during treatment for more than 3 days, or if new symptoms appear, consult a doctor immediately.

Side effect

Allergic reactions: skin rash, itching, urticaria, toxic epidermal necrolysis (Lyell's syndrome), polymorphobullous erythema (Stevens-Johnson syndrome), acute generalized exanthematous pustulosis, angioedema, anaphylactic shock.

From the central nervous system: dizziness, increased excitability (especially in children), sleep disturbance, drowsiness, decreased speed of psychomotor reactions, feeling tired.

From the hematopoietic system: anemia, thrombocytopenia, thrombocytopenic purpura, leukopenia, agranulocytosis, hemolytic anemia, methemoglobinemia, pancytopenia.

From the digestive system: nausea, vomiting, stomach pain, dry mouth, diarrhea.

From the liver and biliary tract: liver damage (increased activity of liver enzymes), hepatitis, as well as dose-dependent liver failure, liver necrosis (including fatal outcomes). Long-term unjustified use can lead to liver fibrosis, liver cirrhosis, including death.

From the respiratory system: bronchospasm or exacerbation of bronchial asthma, including in patients sensitive to acetylsalicylic acid or other NSAIDs.

From the cardiovascular system: palpitations, increased blood pressure.

From the urinary system: urinary retention, with long-term use of high doses nephrotoxic effect.

Other: mydriasis, accommodation paresis, increased intraocular pressure.

Overdose

Symptoms of overdose are caused mainly by paracetamol and appear after taking more than 10–15 g.

In acute overdose, paracetamol has a hepatotoxic effect, including causing liver necrosis.

Overdose may cause nephropathy with irreversible liver failure. The severity of an overdose depends on the dose, so patients should be warned not to take drugs containing paracetamol at the same time. The risk of poisoning is pronounced especially in elderly patients, in children, in patients with liver disease, in cases of chronic alcoholism, in patients with chronic malnutrition (calorie deficiency) and in patients taking inducers of microsomal oxidation in the liver. Overdose of paracetamol can lead to impaired glucose metabolism, hypoglycemia, bleeding, pancreatitis, liver failure, encephalopathy, coma and death.

Symptoms of paracetamol overdose in the first 24 hours: pale skin, nausea, vomiting, anorexia, convulsions. Abdominal pain may be the first sign of liver damage and usually does not appear for 24 to 48 hours and may sometimes appear later, after 4 to 6 days, on average 72 to 96 hours after taking the drug. Impaired glucose metabolism and metabolic acidosis may also occur. Even in the absence of liver damage, acute renal failure and acute tubular necrosis can develop. Cases of cardiac arrhythmia and pancreatitis have been reported.

Treatment: Acetylcysteine ​​administered intravenously or orally as an antidote, gastric lavage, and oral methionine may have a beneficial effect for at least 48 hours after an overdose. It is recommended to take activated carbon and monitor breathing and circulation. If seizures develop, diazepam may be prescribed.

Symptoms of overdose include: drowsiness, which is subsequently accompanied by anxiety (especially in children), visual disturbances, rash, nausea, vomiting, headache, increased excitability, dizziness, insomnia, circulatory disorders (thrombocytopenia, agranulocytosis, leukopenia, pancytopenia), coma , convulsions, increased or decreased blood pressure, bradycardia.

Treatment includes surgical gastric lavage, symptomatic and supportive therapy. The hypertensive effect can be reversed by intravenous administration of an alpha-receptor blocker. In case of seizures, diazepam may be used.

Symptoms of chlorphenamine maleate overdose include drowsiness, respiratory arrest, seizures, anticholinergic effects, dystonic reactions, and cardiovascular collapse including arrhythmia.

In children, symptoms of overdose may include incoordination, agitation, tremors, behavioral changes, hallucinations, seizures, and anticholinergic effects.

Treatment includes gastric lavage in case of massive overdose, or induction of vomiting. After this, it is possible to prescribe activated charcoal and a laxative to slow down absorption. In case of seizures, sedation should be performed with intravenous diazepam or phenytoin. In severe cases, hemoperfusion may be performed.

Interaction with other drugs

Enhances the effects of MAO inhibitors, sedatives, ethanol. The risk of hepatotoxic action of paracetamol increases with simultaneous use of barbiturates, phenytoin, phenobarbital, carbamazepine, rifampicin, isoniazid, zidovudine and other inducers of microsomal liver enzymes. The anticoagulant properties of warfarin and other coumarins may be enhanced by long-term regular use of paracetamol, increasing the risk of bleeding. A single dose of paracetamol does not have this effect. Metoclopramide increases the rate of absorption of paracetamol and increases the level of paracetamol concentration in the blood plasma to the maximum. Likewise, domperidone may increase the rate of absorption of paracetamol.

When chloramphenicol and paracetamol are used together, the half-life of chloramphenicol may increase.

Paracetamol may reduce the bioavailability of lamotrigine, with a possible decrease in its effect due to induction of its hepatic metabolism. The absorption of paracetamol may be reduced when taken concomitantly with cholestyramine, but this can be avoided if cholestyramine is taken one hour after paracetamol. Regular use of paracetamol concomitantly with zidovudine may cause neutropenia and increase the risk of liver damage. Probenecid affects the metabolism of paracetamol. In patients taking probenecid concomitantly, the dose of paracetamol should be reduced. The hepatotoxicity of paracetamol may be increased by chronic or excessive alcohol consumption. Paracetamol may interfere with the results of the uric acid test using the phosphotungstate precipitating reagent.

Contraindicated in patients who are taking or have taken MAOIs within the past two weeks. Phenylephrine can enhance the effect of MAO inhibitors and cause a hypertensive crisis.

Concomitant use of phenylephrine with other sympathomimetic drugs or tricyclic antidepressants (eg, amitriptyline) may increase the risk of cardiovascular side effects. Phenylephrine may reduce the effectiveness of beta blockers and other antihypertensive drugs (eg, debrisoquine, guanethidine, reserpine, methyldopa); The risk of increased blood pressure and other cardiovascular side effects may be increased. Concomitant use of phenylephrine with digoxin and other cardiac glycosides may increase the risk of arrhythmia or myocardial infarction. Concomitant use of phenylephrine with ergot alkaloids (ergotamine and methysergide) may increase the risk of ergotism.

Antihistamines, such as chlorphenamine, may enhance the effects of opioid analgesics, anticonvulsants, antidepressants (tricyclics and monoamine oxidase inhibitors), other antihistamines, antiemetics and antipsychotics, anxiolytics, hypnotics, ethanol (alcohol) and other central nervous system depressants.

Because chlorphenamine has some anticholinergic activity, the effects of anticholinergic drugs (eg, some psychotropic drugs, atropine, and urinary incontinence drugs) may be increased by this drug. This can lead to tachycardia, dry mouth, gastrointestinal disorders (eg, colic), urinary retention and headache.

The metabolism of phenytoin may be inhibited by chlorphenamine, and phenytoin toxicity may develop.

special instructions

If, despite taking the drug, the disease is accompanied by ongoing fever or repeated increases in temperature are observed, you should consult a doctor. Do not take with alcohol or combine with other drugs containing paracetamol. When using Coldact ® Flu Plus, it is not advisable to use sleeping pills, tranquilizers and other psychotropic drugs.

Distorts laboratory test results in the quantitative determination of glucose and uric acid in plasma.

In case of long-term treatment, peripheral blood parameters and the functional state of the liver are monitored.

Impact on the ability to drive vehicles and machinery

During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Release form

Long-acting capsules.

10 capsules in a blister made of aluminum foil and PVC/PVdC film; 1 or 10 blisters with instructions for use in a cardboard box.

Storage conditions

At a temperature not higher than 25°C.

Keep out of the reach of children.

Best before date

Do not use after expiration date.

Vacation conditions

Registration Certificate Holder

Sun Pharmaceutical Industries Ltd., Sun House, Raft No. 201 B/1, Western Express Highway, Goregaon (East), Mumbai -, Maharashtra, India

Sun Pharmaceutical Industries Ltd., Sun House, Plot No. 201 B/1, Western Express Highway, Goregaon (East), Mumbai -, Maharashtra, India.

Manufacturer

Natco Pharma Limited, Kothur, Mahabubnagar District, Telangana, India.

Natco Pharma Limited, Kothur, Mahaboobnagar District, Telangana, India.

Consumer complaints should be sent to the representative office of Sun Pharmaceutical Industries Ltd. by the address:

129223, Moscow, Mira Ave., building. 119, pp. 537/2.

Source: http://medi.ru/instrukciya/koldakt-flyu-plyus_9844/

Koldakt - detailed instructions

Coldact instructions

Koldakt is an antiallergic combination drug. The drug, due to its components, has vasoconstrictor properties, helps normalize the mucous membranes of the respiratory tract and improves their patency. The main component of the drug, phenylpropanolamine, is a symptomatic drug with vasoconstrictor and anorexigenic activity. Thanks to the second component, chlorphenamine, which is an antihistamine drug, all symptoms of allergic rhinitis are suppressed - sneezing and rhinorrhea, itching in the eyes, nose and throat.

Coldact composition

The drug is available in the form of syrup, tablets and capsules.

The syrup of this drug contains substances such as chlorpheniramine maleate BP, phenirpropanolamine hydrochloride BP, and a flavored base for the syrup. Tablets and capsules contain chlorpheniramine maleate BP, phenylpropanolamine hydrochloride BP.

Coldact application

The medicine Koldakt is used in case of colds, rhinitis and rhinorrhea, sinusitis, nasopharyngitis and allergic rhinitis.

Coldact dosage

The medicine is intended for oral administration. Adults are prescribed to take 1 capsule about two times a day. Capsules should be swallowed whole, without chewing, and washed down with plenty of water. Treatments for influenza and ARVI last approximately three days. In case of acute sinusitis, take 1 capsule about twice a day. The duration of treatment for acute sinusitis is approximately 12 days, for chronic sinusitis – about 30 days. When treating rhinorrhea, 1 capsule is prescribed once a day. The duration of treatment is about 7 days.

For children aged 5-6 years, about 5 ml of syrup is prescribed. every 4 or 6 hours; children aged 6-12 years are prescribed syrup in a dose of 5 ml every 4 hours. The duration of treatment for children is about 5 days.

Coldact flu plus

The drug is available in the form of capsules that have a prolonged effect. They contain phenylephrine hydrochloride, chlorphenamine maleate and paracetamol. With the use of capsules that have an antiallergic effect, they eliminate lacrimation and itching in the eyes and nose. Thanks to paracetamol, which has analgesic and antipyretic properties, it reduces pain symptoms that appear during colds, such as sore throat, headache, muscle and joint pain, and lowers temperature. Unlike paracetamol, phenylephrine has vasoconstrictor properties, which reduce swelling and hyperemia of the mucous membranes of the respiratory tract and in the paranasal sinuses.

Coldact Flu Plus is used in the symptomatic treatment of colds, in the treatment of influenza, ARVI.

For the treatment of adults and children over 12 years of age, the medicine is prescribed in the following dose: 1 capsule every 12 hours. The duration of treatment is about 5 days. The drug is used as an antipyretic for no more than 3 days, and as an analgesic for no more than 5 days.

Coldact Broncho

The drug is produced in the form of syrup, which is a combination product. Thanks to its constituent Guaifenesin and Ambroxol, which are mucolytic substances, it can reduce the viscosity of bronchial secretions and facilitate expectoration of sputum. In addition, chlorphenamine, which is part of it, has an antihistamine effect and is able to eliminate itching of the mucous membranes of the nose and eyes, eliminate bleeding, and phenylephrine, an alpha1-adrenergic stimulant, has vasoconstrictor properties and is able to reduce swelling and hyperemia of the mucous membranes of the respiratory tract and paranasal sinuses.

The medicine is used for the symptomatic treatment of colds, influenza, ARVI, which are accompanied by a severe cough and difficult-to-discharge sputum of a viscous consistency.

For the treatment of adults and children over the age of 12 years, 20 ml of syrup is prescribed about three times a day. Children aged 6-12 years are prescribed 10 ml of syrup about three times a day. The duration of treatment is usually 7 days.

Coldact Lorpis

The drug is an antiseptic and is available in the form of tablets with different flavors. This medicine has anti-inflammatory, analgesic and local anesthetic effects. The components included in its composition are capable of coagulating proteins in microbial cells and are active against gram-positive and gram-negative microorganisms, and thanks to them the medicine has antifungal properties. With its use, symptoms that appear when irritation of the mucous membranes of the respiratory tract are eliminated, since the drug has a decongestive effect on the mucous membranes. Using it in treatment, nasal congestion decreases and irritation and sore throat are not so severe.

This type of drug is used in the case of infectious and inflammatory diseases of the mouth, throat, larynx, that is, tonsillitis, pharyngitis, laryngitis. The medication is effective for hoarseness, inflammation of the mucous membranes in the mouth, gums, that is, for aphthous stomatitis, gingivitis and thrush.

For the treatment of adults and children, 1 tablet is prescribed every 3 hours; the tablets are not swallowed, but kept in the mouth until completely dissolved. You can take no more than 8 tablets per day.

Coldact during pregnancy

The drug should not be used to treat pregnant women or during lactation.

Koldakt analogues

Analogues of the drug are drugs that are similar in their active substance, such as Adjisept, AntiFlu, Astrasept, Gorpils, Koldar, Contact 400, Orinol, Rinza Lorsept, Strepsils, Suprima ENT, Terasil, TeraFlu Extratab.

Coldact contraindications

Treatment with the drug is not prescribed in case of hypersensitivity to one of its components, with severe atherosclerosis of the coronary arteries, with arterial hypertension, with diabetes mellitus, thyrotoxicosis and closed-angle glaucoma. The drug is also contraindicated in patients suffering from kidney, liver, heart, and severe bladder diseases, as well as in patients with stomach and duodenal ulcers, pancreatic disease, and glucose-6-phosphate dehydrogenase deficiency. You should not take the medicine in case of difficulty urinating due to prostate adenoma and diseases of the blood system, as well as for pregnant women and during lactation. Coldact Flu plus is not prescribed to children under 12 years of age, Coldact Broncho is not prescribed to children under 6 years of age, Coldact Lorpis is not prescribed to children under 5 years of age.

Coldact price

The cost of the drug depends on the form of release, the country of manufacture and the region in which it is sold, so the real price of the drug should be checked in local pharmacies. The approximate price of the drug Koldakt ranges from 87.10 rubles. up to 129 rub.

Koldakt reviews

The doctor prescribed treatment with Koldakt in syrup form to my son for acute rhinitis. The medicine worked immediately and after a few days of taking it my son felt much better, and after a full course of treatment the disease went away for good. The medicine is effective and acts quickly.

Source: http://nasmork-rinit.com/meditsinskie-preparaty/278-koldakt-razvernutaya-instruktsiya

COLDACT FLU PLUS

10 pieces. - blisters (1) - cardboard packs.

Combined drug with prolonged action.

Chlorphenamine has an antiallergic effect, eliminates lacrimation, itching in the eyes and nose.

Paracetamol has an antipyretic and analgesic effect: it reduces the pain syndrome observed during colds - sore throat, headache, muscle and joint pain, and reduces high fever.

Phenylephrine has a vasoconstrictor effect - reduces swelling and hyperemia of the mucous membranes of the upper respiratory tract and paranasal sinuses.

- hypersensitivity to any of the components included in the composition;

- severe atherosclerosis of the coronary arteries;

- severe diseases of the liver, kidneys, heart, bladder;

- peptic ulcer of the stomach and duodenum;

- diseases of the pancreas;

- difficulty urinating with prostate adenoma;

— diseases of the blood system;

- children under 12 years of age.

With caution : congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), bronchial asthma and chronic obstructive pulmonary disease.

Adults and children over 12 years old - 1 capsule every 12 hours for 3-5 days.

Duration of use as an antipyretic - no more than 3 days; as a pain reliever - no more than 5 days.

Increased blood pressure, tachycardia, drowsiness, difficulty falling asleep, dizziness, increased excitability, dry mucous membranes, mydriasis, accommodation paresis, increased intraocular pressure, loss of appetite, nausea, epigastric pain, anemia.

Very rare: urinary retention, allergic reactions (skin rash, itching, urticaria, angioedema).

Rarely: anemia, thrombocytopenia, leukemia, agranulocytosis.

With long-term use in high doses, hepatotoxic and nephrotic effects are possible.

Symptoms caused by paracetamol appear after taking more than one day: pallor of the skin, decreased appetite, nausea, vomiting, hepatonecrosis, increased activity of liver transaminases, increased prothrombin time.

Treatment : gastric lavage in the first 6 hours, administration of SH-group donors and precursors for the synthesis of glutathione-methionine 8-9 hours after an overdose and N-acetylcysteine ​​after 12 hours. In case of accidental overdose, you should immediately consult a doctor, regardless of what is noted -either symptoms of overdose or not.

The risk of developing hematotoxic effects of paracetamol increases with simultaneous use of barbiturates, diphenine, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes.

Enhances the effects of sedatives, ethanol, and MAO inhibitors.

Antidepressants, phenothiazine derivatives, antiparkinsonian and antipsychotic drugs increase the risk of developing urinary retention, dry mouth, and constipation.

GCS increase the risk of developing glaucoma.

Paracetamol reduces the effectiveness of uricosuric drugs.

Chlorphenamine combined with furazolidone can lead to hypertensive crisis, agitation, and hyperrexia.

Tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine; simultaneous administration of halothane increases the risk of developing ventricular arrhythmia.

Reduces the hypotensive effect of guanethidine, which in turn enhances the alpha-adrenergic stimulating activity of phenylephrine.

Without a doctor's instructions, the drug should not be used by patients undergoing treatment with other medications, in particular MAO inhibitors. If, despite taking the drug, the disease is accompanied by ongoing fever or repeated increases in temperature are observed, you should consult a doctor. Do not take with alcohol or combine with other drugs containing paracetamol. When using Coldact Flu Plus, it is not advisable to use sleeping pills, tranquilizers and other psychotropic drugs.

Distorts laboratory test results in the quantitative determination of glucose and uric acid in plasma. In case of long-term treatment, peripheral blood parameters and the functional state of the liver are monitored.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Store in a dry place at a temperature not exceeding 25°C. Keep out of the reach of children.

Shelf life: 2 years. Do not use after expiration date.

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Source: http://health.mail.ru/drug/coldact_flu_plus/

Coldact

Instructions for use:

Prices in online pharmacies:

Koldakt is a drug that has an anticongestive, vasoconstrictor and antihistamine effect, used for the symptomatic treatment of colds.

Release form and composition

Koldakt is produced in the form of long-acting capsules (10 pieces in blisters, 1 blister in a cardboard pack) and syrup for oral administration (in 60 ml bottles, 1 bottle in a cardboard pack).

Active ingredients of the drug:

  • Chlorpheniramine maleate VR: in 1 capsule – 8 mg, in 5 ml of syrup – 2 mg;
  • Phenylpropanolamine hydrochloride BP – in 1 capsule – 50 mg, in 5 ml of syrup – 10 mg.

Indications for use

Koldakt is intended for the symptomatic treatment of diseases accompanied by allergization of the body, nasal congestion, runny nose, swelling of the mucous membrane of the upper respiratory tract, sore throat, lacrimation, such as acute respiratory viral infections (ARVI), influenza, sinusitis, acute, chronic and allergic rhinitis.

Contraindications

  • Severe form of hypertension;
  • Cardiac ischemia;
  • Children under 1 year of age – for syrup, up to 12 years – for capsules;
  • Pregnancy;
  • Lactation period;
  • Hypersensitivity to the components of the drug.

Koldakt is prescribed with caution in the following cases: urinary retention, angle-closure glaucoma, bronchial asthma, uncontrolled diabetes mellitus, hyperthyroidism, obstructive conditions of the gastrointestinal tract, epilepsy.

Directions for use and dosage

Both dosage forms of Koldakt are taken orally, preferably after meals.

Capsules are prescribed for children over 12 years of age and adults - 1 piece. every 12 hours. Duration of treatment:

  • Flu and ARVI – 1-3 days;
  • Allergic rhinitis – 3-6 days;
  • Sinusitis – 6-12 days;
  • Chronic rhinitis – 30 days.

In the form of syrup, the drug is mainly prescribed to children. Recommended doses depending on age:

  • 2-6 years – 2.5 ml (1/2 tsp) every 4-6 hours or as prescribed by a doctor;
  • 6-12 years – 5 ml (1 tsp) every 4-6 hours;
  • Over 12 years old – 5-10 ml (1-2 tsp) every 4-6 hours.

Side effects

In general, Koldakt is well tolerated. In rare cases, it is possible:

  • Dizziness, headache, drowsiness, sleep disturbance, irritability, feeling tired, agitation;
  • Dry mouth, diarrhea, nausea and/or vomiting, decreased appetite, tone and motility of the gastrointestinal tract;
  • Dysuric phenomena;
  • Dryness of the mucous membrane of the respiratory tract;
  • Increased blood pressure;
  • Visual impairment;
  • Feeling of constriction in the chest.

special instructions

The risk of side effects is greater in older people and patients with a tendency to increase blood pressure.

During the treatment period, it is recommended to refrain from performing activities that require increased attention and speed of mental and/or motor reactions (including driving vehicles).

Drug interactions

When taking monoamine oxidase inhibitors and furazolidone simultaneously, the risk of developing hyperpyrexia, agitation and hypertensive crisis increases; halothane - ventricular arrhythmia.

Koldakt reduces the hypotensive effect of guanethidine, and it enhances the activity of phenylpropanolamine.

Tricyclic antidepressants enhance the sympathomimetic effect of Koldakt, and it increases the effect of hypnotics and sedatives.

The drug is incompatible with alcohol.

Terms and conditions of storage

Store at temperatures up to 25 ºС in a place protected from light, out of reach of children.

Shelf life – 3 years.

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Koldakt: brief instructions, analogues

Koldakt is a powerful combination drug for colds and allergies. It is intended to relieve or reduce the severity of clinical symptoms, and does not in any way affect the cause of the pathology. The components of this medicine have vasoconstrictor (vasoconstrictor), anticongestive (decongestant) and antihistamine (antiallergic) properties.

Active ingredients and dosage forms

This pharmacological agent is produced in the form of capsules (long-acting), suspension, powder for preparing a solution and syrup for children.

Coldact capsules contain 50 mg of phenylpropanolamine hydrochloride and 8 g of chlorpheniramine maleate.

Each Coldact Flu Plus capsule additionally contains 200 mg of paracetamol, and the dose of phenylephrine hydrochloride is half as much (25 mg).

In 5 ml of Koldakt syrup for children (1 scoop) - 10 mg of phenylpropanolamine hydrochloride and 2 mg of chlorpheniramine.

Capsules are supplied in blisters (10 pieces each), and syrup - in bottles (60 ml).

Note! Due to the fact that the granular contents of Coldact Flu Plus capsules dissolve and are absorbed in the gastrointestinal tract gradually, the medicine acts within hours.

What does Koldakt help with?

The drug helps relieve symptoms of inflammation of the paranasal sinuses, as well as acute, chronic and allergic rhinitis.

Coldact is prescribed for the following diseases:

The product eliminates swelling, sore throat, nasal congestion, rhinorrhea, and lacrimation.

Contraindications

Please note: the drug in capsules is not prescribed to children and adolescents under 12 years of age.

An absolute contraindication is individual hypersensitivity to the active or auxiliary ingredients of the drug.

Coldact should not be taken in severe cases of coronary heart disease and severe hypertension.

Dosage regimen and recommended dosages

A single dose is 1 capsule, and the frequency of administration is 2 times a day, observing a 12-hour time period. It is recommended to drink the drug after meals.

For influenza and ARVI, symptomatic treatment according to indications is continued for 1 to 3 days. Allergic rhinitis requires taking Coldact capsules for 3-6, and chronic rhinitis – up to 30 days. For sinusitis, the medicine is taken on average from one to one and a half weeks.

Coldact syrup is given to children every 4-6 hours.

Single dosages (by age):

  • 2-6 years – half a teaspoon (2.5 ml);
  • 6-12 – 5 ml;
  • 12 or more – 5-10 ml per dose.

pharmachologic effect

Chlorpheniramine is able to block specific receptors of the main allergy mediator - histamine. The substance is characterized by moderately expressed sedative (calming) and antimuscarinic properties. It reduces the permeability of vascular walls, which helps reduce inflammatory exudation.

Another active substance, phenylpropanolamine, is an indirect-acting sympathomimetic. Its action is similar to that of ephedrine, but it affects the central nervous system to a lesser extent. The compound helps reduce congestion in the mucous membranes of the upper respiratory system.

Coldact stimulates α-adrenergic receptors and constricts blood vessels, thereby reducing hyperemia and swelling of the mucous membranes of the respiratory tract and nasal sinuses.

Paracetamol inhibits the enzyme cyclooxygenase and affects the hypothalamic centers of thermoregulation and pain. This compound helps reduce high fever and relieve headaches and muscle pain during colds and acute respiratory viral infections (including influenza).

After oral administration of Coldact capsules, the active components are absorbed gradually in the digestive tract. The maximum serum concentration of chlorpheniramine is recorded after 2-6 hours. Its biotransformation occurs in the liver, and the unchanged substance and its metabolites are excreted mainly by the kidneys. The peak concentration of phenylpropanolamine in plasma is reached after 1-2 hours. The substance leaves the body mainly unchanged in the urine.

Side effects

If the components are intolerant, there is a possibility of developing allergic reactions - skin itching and rashes (urticaria), angioedema and bronchospasm. In severe cases, anaphylactic shock cannot be ruled out.

Most patients tolerate Koldakt well.

In rare cases, the following side effects have been reported:

Overdose

There have been no cases of overdose of Koldakt. If single and daily doses of Kodakt FluPlus are significantly exceeded, paracetamol poisoning cannot be ruled out.

Interaction with other drugs

Koldakt is capable of potentiating the effect of sedative (sedative) and hypnotic pharmacological agents.

During treatment, you should refrain from taking pharmaceutical alcohol tinctures and alcoholic beverages.

Parallel use of furazolidone and monoamine oxidase inhibitors increases the likelihood of a sharp rise in blood pressure (up to a hypertensive crisis). With simultaneous use of Halothane, ventricular arrhythmia cannot be excluded. Guanethidine increases the activity of phenylpropanolamine.

Coldact during pregnancy

During pregnancy and breastfeeding, it is not recommended to take this remedy for colds and flu. This is especially true for Coldact FluPlus, which contains paracetamol.

A doctor may recommend a drug if the benefit to the mother outweighs the likely risk to the fetus. If symptomatic treatment is necessary during lactation, it is advisable to temporarily transfer the child to breastfeeding.

Additionally

Coldact should be taken with caution in case of the following diseases and pathological conditions:

The combined use of antibiotics (according to indications for diseases of bacterial origin), mucolytics and expectorants helps to speed up the healing process.

During treatment, it is recommended to refrain from activities that require increased concentration, including driving vehicles and working with potentially dangerous mechanisms.

Conditions for storage and release from pharmacies

To purchase Koldakt in pharmacy chains you do not need a prescription.

The medicine should be kept in places with low humidity at a temperature not exceeding +25°C.

The shelf life of capsules is 3 years from the date of release (it is marked on the packaging).

Keep away from children!

Koldakt's analogues

Analogues of the drug are:

Plisov Vladimir, medical observer

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