Amoxiclav dosage for children

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How to give Amoxiclav to a 5 year old child?

Amoxiclav suspension is developed and intended for use in childhood. With its help you can effectively fight inflammatory and infectious diseases.

Table of contents:

The widespread use of this drug by parents is due to the fact that it has virtually no harmful effects on the growing body. Prescribing Amoxiclav to a 5-year-old child is a doctor’s job, and you should not resort to using it yourself.

What is Amoxiclav

Amoxiclav is a strong antibiotic that contains penicillin and amoxicillin, as well as a beta-lactamase inhibitor, qualuvanic acid. This combination has a pronounced bactericidal effect, effectively coping with negative microflora in the body.

Purpose

Doctors prescribe Amoxiclav for children aged 5 years when the following diseases occur:

  • sinusitis;
  • upper respiratory tract diseases;
  • pneumonia;
  • bronchitis;
  • tonsilopharyngitis;
  • infectious lesions of the urinary system.

In some cases, taking this drug is recommended for inflammatory processes of soft tissue, bones and joints.

How to prepare the drug

Amoxiclav is prepared by mixing 85 ml of powder with water in two steps. After this, the resulting solution should be shaken well, after which it is ready for use.

It should be stored in the refrigerator, but no more than a week, after which it becomes unfit for consumption.

Application of Amoxiclav

Before starting treatment with this drug, you must carefully study the instructions for use of Amoxiclav. You should strictly adhere to the prescribed dosage, which depends on the age of the child.

For children over 14 years of age, Amoxiclav is available in the form of tablets; take one tablet three times a day.

In addition, the dosage of the drug may vary depending on body weight and the severity of the pathological process.

Example of dosage for a child aged 5 years and weighing 18 kg

Mild to moderate infections:

  • suspension 125 mg + 31.25 mg/5 ml - you need to give 4.8 ml 3 times a day;
  • suspension 250 mg + 62.5 mg/5 ml - you need to give 2.4 ml 3 times a day.
  • suspension 125 mg + 31.25 mg/5 ml - you need to give 9.6 ml 3 times a day;
  • suspension 250 mg + 62.5 mg/5 ml - you need to give 4.8 ml 3 times a day.

If your baby’s weight is different, then the dosage should be selected according to the table below.

Amoxiclav dosage tables for children from 3 months by weight

To open a photo, double-click on it.

Contraindications

Like any other drug, Amoxiclav has a number of contraindications:

  • In no case should this drug be given to children who suffer from allergic diseases, namely: bronchial asthma or dermatitis;
  • In addition, in some cases it is contraindicated in case of individual intolerance to the components of the drug;
  • It should not be used for diseases affecting the kidneys;
  • Taking Amoxiclav should not be taken simultaneously with taking medications containing macrolides, sulfonimides and tetracyclines.

According to reviews, giving Amoxiclav in suspension to a 5-year-old child is one of the most effective and safest ways to get rid of many viral and infectious diseases. Analogs of this antibiotic are among the most effective of the penicillin group, and the positive effect of taking it will be noticeable after the first use.

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IMPORTANT. The information on the site is provided for informational purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

Source: http://pillsman.org/24074-amoksiklav-rebenku-5-let.html

Amoxiclav 250 mg tablets for children - instructions for use

Use of tablets. Also, children over 12 years of age and weighing more than 40 kg are prescribed 1 tablet every 8 hours.

1-2 years old

2-4 years, 5 ml

4 - 6 years ml

6 -10 years, 5 ml

years, 5 ml

Such drugs can cause allergies and have other side effects. Therefore, children (as well as adults) should only be prescribed this medicine by a qualified doctor, after diagnosis and identification of the pathogen.

Source: http://www.rasteniya-lecarstvennie.ru/24276-amoksiklav-250-mg-tabletki-dlya-detey-instrukciya-po-primeneniyu.html

Amoxiclav for children - antibiotic prescription and dosage by age

Loving parents not only care about the health of their child, but also try to give him the safest and most effective medications during illness. The younger the child, the more difficult it is to persuade him to take a medicine, so the modern pharmaceutical industry produces drugs for children in a very successful form - in the form of a suspension. Typically, such medicines have a pleasant sweet taste and fruity aroma. This helps the child perceive the syrup or suspension not as a medicine, which by definition must have an unpleasant taste, but as ordinary syrup. This approach makes it much easier for parents to treat their baby.

Amoxiclav, produced in different forms and intended for children of different age groups, is currently considered one of the most effective antibacterial children's drugs. There are many analogs of this product that use the same or very similar formula and work in a similar way. All of these drugs contain antibiotics and are used only as prescribed by a doctor.

Composition of Amoxiclav, its properties and release form

Amoxiclav is a broad-spectrum antibiotic from the penicillin series in combination with clavulanic acid.

Amoxiclav is available in the form of a suspension for young children, and for adolescents over 12 years of age - in tablet form. This drug is most popular in suspension, since the package includes a dry powder, which is diluted with water to obtain the finished drug as needed. Each package contains a dark glass bottle with ready-made Amoxiclav powder, and is also equipped with a measuring pipette for babies and a plastic spoon for older children who can drink the product from it.

The 5 ml suspension contains 125 mg of amoxicillin trihydrate and 31.25 mg of clavulanic acid potassium salt. The additional substances in the preparation are citric acid, sodium citrate, sodium benzoate, xanthan gum as a thickener, strawberry flavor and several other auxiliary agents and fillers.

The medicine is available with different percentages of amoxicillin and clavulanic acid. If you go by the amount of antibiotic, then the suspension can contain 125, 250 or 400 mg of the active substance plus clavulanic acid. Amoxiclav is used for various diseases caused by pathogens sensitive to penicillins.

The drug is usually very well tolerated and accepted by children due to its form and pleasant taste.

The medicine acts very quickly - after about an hour the beginning of the therapeutic effect is already noted. When prescribed correctly, the child feels relief very quickly, and the disease begins to recede.

There are special marks on the bottle, according to which you can prepare different amounts of the drug intended for treating children of different ages. Pure water at room temperature is added to the powder, the bottle is tightly closed and shaken well until the drug is completely dissolved.

Useful video - How to properly treat a child with antibiotics:

The finished product is stored for no more than a week in the bottom of the refrigerator, in a tightly closed container. You cannot give the product cold; you need to wait until it warms up to room temperature. When the shelf life ends, the remaining suspension must be discarded. The undiluted drug has a shelf life of 24 months and is stored away from children, in a shaded and cool place.

Purpose of the drug

Most often, Amoxiclav is prescribed to children for the treatment of respiratory tract diseases caused by bacterial infection.

Amoxiclav is used to treat the following diseases:

  • Lesions of the upper respiratory tract of bacterial origin, including tonsillitis, pharyngitis, retropharyngeal abscess.
  • Acute and chronic otitis.
  • Sinusitis in different forms and manifestations.
  • Lesions of the lower respiratory tract, including acute and chronic bronchitis, pneumonia.
  • Urinary tract infections.
  • Lesions of the skin and soft tissues.
  • Bone and connective tissue infections.
  • Infectious diseases of the biliary tract.
  • Oral lesions.

The drug has a wide range of uses, but prescribing it yourself can be dangerous. You need to be firmly convinced that the child’s illness is caused by a bacterial infection, since antibiotics are useless to fight diseases of a viral nature, and with fungal infections they can generally cause serious harm, since they will serve as stimulants of the disease.

In addition, antibiotics often cause allergies and have side effects, so consultation with a pediatrician is essential, especially if we are talking about a very young child or infant.

Children's dosage and rules for using the product

The dosage and course of antibiotic treatment should be prescribed by a doctor, depending on the severity of the disease.

The dosage of Amoxiclav for children must be calculated not so much according to age, but according to their weight, because children can be different - kids of the same age can be both thin and overweight.

Each age group has its own prescriptions and dosages:

  • Newborns and infants up to 3 months of age. For them, powder is used to prepare a suspension, which is dissolved in water and given to the child using a pipette included with the medicine. The dosage is calculated per serving of amoxicillin. At this age, children are given 30 mg per kg of weight, dividing the drug into two doses per day.
  • Children over 3 months of age are prescribed 20 mg per kg of weight, and for severe infections (otitis media, bronchitis, severe runny nose with purulent discharge, pneumonia), the dose is increased to 40 mg per kg. The maximum dose of the drug that can be prescribed to a child per day is 45 mg per kg.

To accurately calculate the dose of the drug, a special table is used:

The suspension dose of 125 and 250 ml indicated in the table is used three times a day, and the drug 400 ml is used twice a day. In the case of severe infections, with the consent of the doctor, the dosage is increased by a third relative to that recommended for use in mild to moderate diseases.

The duration of treatment usually ranges from 5 days to two weeks, depending on the severity of the disease and the patient’s condition.

Exceeding the recommended dosage and time of administration can be dangerous, but if the disease does not go away, this may indicate an incorrect diagnosis or the ineffectiveness of the chosen remedy against an existing infection.

During treatment, parents or caregivers should carefully monitor the child's condition and behavior. The appearance of signs of allergic reactions, inappropriate behavior, deterioration of the condition or unusual effects should be a reason to discontinue the drug and call a pediatrician.

Contraindications to the use of Amoxiclav

Amoxiclav is an effective antibiotic, but has a number of limitations for use

Like many other drugs containing antibiotics, Amoxiclav has its own number of contraindications:

  • Allergic reactions to antibiotics or to other components included in the drug. If a child suffers from any type of allergy, it is first necessary to obtain the doctor’s consent and do a drug tolerance test.
  • Hypersensitivity to antibiotics belonging to the penicillin, cephalosporin or any other beta-lactam group. With such hypersensitivity, extremely dangerous conditions may occur, even threatening the baby’s life.
  • If the child has previously had problems with the liver and gall bladder caused by the use of similar drugs.
  • Disease of infectious mononucleosis.
  • Lymphocytic leukemia.

If a child has severe kidney damage, liver failure or pseudomembranous colitis, prescribing the drug is entirely the responsibility of the doctor. It is used only if the expected benefit may be much higher than the risk of any complications.

Amoxiclav should not be mixed with other antibiotics and combined with other drugs with caution. Do not give your child any medications other than those prescribed by the doctor.

Side effects

In no case should you exceed the dosage of Amoxiclav, this can be dangerous for the child

Amoxiclav for children is in the vast majority of cases very well tolerated and rarely causes side effects.

In most cases, they are manifested by the following conditions:

  • Allergic reactions. Most often it manifests itself in the form of urticaria or erythema (redness with irritation), as well as other types of skin rashes accompanied by severe itching, scabies, inflammation and redness of the skin. It can also manifest itself as swelling of the mucous membranes of the respiratory tract, eye damage, anaphylactic shock, angioedema.
  • Lesions of the digestive system. Most often, there is a decrease or lack of appetite, nausea, which can be complicated by vomiting and intestinal upset. In very rare cases, abdominal pain, liver damage, jaundice and other complications may occur.
  • Lymphatic and hematopoietic system. In very rare cases, leukopenia and thrombocytopenia, eosinophilia, hemolytic anemia and other problems with blood composition are observed.
  • The kidneys are also extremely rarely affected, but crystalluria and some types of nephritis may appear.
  • The nervous system may react with headache, dizziness, irritability combined with hyperactivity, insomnia and anxiety. In rare cases, seizures may occur. A previously calm and balanced child may become nervous and capricious, but this condition may not be caused by the drug, but by the disease itself, especially if it is severe.
  • Candidiasis may occur.

Analogues of Amoxiclav

Pharmaceutical companies produce drugs that have exactly the same composition as Amoxiclav, only under different names. The most common synonyms for this remedy are Moxiclav, Augmentin, Clavocin. These drugs are used similarly to Amoxiclav.

There are also many analogues of this product that have a similar composition and effect. The most popular and available in all pharmacies include the following drugs: Clamosar, Amoxicillin, Panclave, Ecoclave, Amocombe, Bactoclav, Toromentin and many others.

When using analogues of Amoxiclav, you need to take into account possible subtleties in the use of each specific product, so before using the drug you must carefully read the instructions. Although all analogues of Amoxiclav have a similar composition, their creators may use some different substances, so they may have a different effect on the child’s health. Only a careful, even meticulous attitude towards the use of an antibiotic can prevent the occurrence of various unexpected and unpleasant side effects or negative reactions.

The use of any antibiotics to treat a child requires mandatory consultation with a specialist and compliance with the exact dosage and duration of treatment as prescribed by the doctor or following the instructions for the drug.

Only in this case will it be possible to avoid dangerous complications and side effects of the drug. Any self-medication, especially in relation to a newborn, infant or small child, can lead to extremely dangerous complications or multiple side effects

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Comments (2)

Olga

10/08/2016 at 23:22 | #

Augmentin is a really excellent drug, I’ve seen it from my own experience. I am a mother of three children and amoxiclav is my lifesaver; I have treated both ears and sore throat with it more than once. He has been helping us out for 10 years now.

08/22/2017 at 10:47 am | #

if you don’t get carried away with antibiotics, then amoxiclav can be used to treat serious illnesses - in my case, it helped a lot with prostatitis, and I didn’t drink anything extra, I just went on Smartprost. I think this is because for trifles like a sore throat, I never take antibiotics; I use local remedies. And now, since childhood, everyone has been stuffed with these antibiotics.

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Amoxiclav suspension - official instructions for use

on the use of the drug

for medical use

Read these instructions carefully before you start taking/using this medicine:

• save the instructions, you may need them again.

• If you have any questions, consult your doctor.

• This medicine is for you personally and should not be given to others because it may harm them even if they have the same symptoms as you.

Registration number:

Trade name of the drug:

Group name:

Dosage form:

powder for the preparation of suspension for oral administration.

Compound:

Each 5 ml of suspension 400 mg+57 mg/5 ml contains:

active substances: amoxicillin (in the form of trihydrate) in terms of the active substance – 400 mg; clavulanic acid (in the form of potassium salt) in terms of the active substance – 57 mg; excipients: citric acid (anhydrous) – 2.694 mg; sodium citrate (anhydrous) – 8.335 mg; microcrystalline cellulose and carmellose sodium – 28.1 mg; xanthan gum – 10.0 mg; colloidal silicon dioxide – 16.667 mg; silicon dioxide – 0.217 g; wild cherry flavor – 4,000 mg; lemon flavoring – 4,000 mg; sodium saccharinate – 5,500 mg; mannitol up to 1250 mg.

Each 5 ml of suspension 250 mg + 62.5 mg/5 ml contains:

active substances: amoxicillin (in the form of trihydrate) in terms of the active substance – 250 mg; clavulanic acid (in the form of potassium salt) in terms of the active substance – 62.5 mg; excipients: citric acid (anhydrous) – 2.167 mg; sodium citrate (anhydrous) – 8.335 mg; sodium benzoate – 2.085 mg; microcrystalline cellulose and carmellose sodium – 28.1 mg; xanthan gum – 10.0 mg; colloidal silicon dioxide – 16.667 mg; silicon dioxide – 0.217 g; wild cherry flavor – 4,000 mg; sodium saccharinate – 5,500 mg; mannitol up to 1250 mg.

Each 5 ml of suspension 125 mg + 31.25 mg/5 ml contains:

active substances: amoxicillin (in the form of trihydrate) in terms of the active substance – 125 mg; clavulanic acid (in the form of potassium salt) in terms of the active substance – 31.25 mg; excipients: citric acid (anhydrous) – 2.167 mg; sodium citrate (anhydrous) – 8.335 mg; sodium benzoate – 2.085 mg; microcrystalline cellulose and carmellose sodium – 28.1 mg; xanthan gum – 10.0 mg; colloidal silicon dioxide – 16.667 mg; silicon dioxide – 0.217 g; strawberry flavoring – 15,000 mg; sodium saccharinate – 5,500 mg; mannitol up to 1250 mg.

Description: Powder: white to yellowish-white.

Suspension: Almost white to yellow homogeneous suspension.

Pharmacotherapeutic group:

antibiotic – semi-synthetic penicillin + beta-lactamase inhibitor.

Pharmacological properties

Amoxicillin is a semisynthetic broad-spectrum antibiotic that is active against many gram-positive and gram-negative microorganisms. At the same time, amoxicillin is susceptible to destruction by beta-lactamases, and therefore the spectrum of activity of amoxicillin does not extend to microorganisms that produce this enzyme.

Clavulanic acid is a beta-lactamase inhibitor, structurally related to penicillins, and has the ability to inactivate a wide range of beta-lactamases found in microorganisms resistant to penicillins and cephalosporins. Clavulanic acid is sufficiently effective against plasmid beta-lactamases, which most often cause bacterial resistance, and is not effective against type I chromosomal beta-lactamases, which are not inhibited by clavulanic acid.

The presence of clavulanic acid in the drug protects amoxicillin from destruction by enzymes - beta-lactamases, which allows expanding the antibacterial spectrum of amoxicillin.

Below is the activity of the combination of amoxicillin and clavulanic acid in vitro.

Gram-negative aerobes: Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella catarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Other: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Gram-positive anaerobes: species of the genus Clostridium, Peptococcus niger, Peptostrepiococcus magnus, Peptostreptococcus micros, species of the genus Peptostreptococcus.

Gram-negative anaerobes: Bacteroides fragilis, species of the genus Bacteroides, species of the genus Capnocytophaga, Eikenella corrodens, Fusobacterium nucleatum, species of the genus Fusobacterium, species of the genus Porphyromonas, species of the genus Prevotella.

to a combination of amoxicillin and clavulanic acid

Gram-positive aerobes: species of the genus Corynebacterium, Enterococcus faecium.

to a combination of amoxicillin and clavulanic acid

Other: Chlamydia pneumoniae, Chlamydia psittaci, species of the genus Chlamydia, Coxiella burnetii, species of the genus Mycoplasma.

1 For these bacteria, the clinical effectiveness of the combination of amoxicillin with clavulanic acid has been demonstrated in clinical studies.

2 strains of these bacterial species do not produce beta-lactamases. Sensitivity during amoxicillin monotherapy suggests similar sensitivity to the combination of amoxicillin and clavulanic acid.

The active ingredients of the drug are quickly and completely absorbed from the gastrointestinal tract (GIT) after oral administration. Absorption of active ingredients is optimal when the drug is used with food.

The following are the pharmacokinetic parameters of amoxicillin and clavulanic acid after administration at a dose of 45 mg/6.4 mg/kg, divided into two doses, by patients under 12 years of age.

Average value of pharmacokinetic parameters

Tmax – time to reach maximum concentration in blood plasma;

AUC – area under the concentration-time curve;

T1/2 – half-life.

About% of the initial dose of amoxicillin is excreted by the kidneys in the form of an inactive metabolite (penicillic acid). Clavulanic acid in the human body undergoes intensive metabolism with the formation of 2,5-dihydro-4-(2-hydroxyethyl)-5-oxo-1H-pyrrole-3-carboxylic acid and 1-amino-4-hydroxy-butan-2-one and is excreted by the kidneys, through the gastrointestinal tract, and also with exhaled air in the form of carbon dioxide.

As with intravenous administration of a combination of amoxicillin and clavulanic acid, therapeutic concentrations of amoxicillin and clavulanic acid are found in various tissues and interstitial fluid (gallbladder, abdominal tissue, skin, adipose and muscle tissue, synovial and peritoneal fluids, bile, purulent discharge) .

Amoxicillin and clavulanic acid have a weak degree of binding to plasma proteins. Studies have shown that about 25% of the total amount of clavulanic acid and 18% of amoxicillin in the blood plasma is bound to plasma proteins.

The volume of distribution is approximately 0.3-0.4 L/kg for amoxicillin and approximately 0.2 L/kg for clavulanic acid.

Amoxicillin and clavulanic acid do not penetrate the blood-brain barrier when the meninges are not inflamed. Amoxicillin (like most penicillins) is excreted in breast milk.

Trace amounts of clavulanic acid may also be found in breast milk. With the exception of the possibility of sensitization, diarrhea and candidiasis of the oral mucosa, there are no other known negative effects of amoxicillin and clavulanic acid on the health of breastfed infants.

Animal reproductive studies have shown that amoxicillin and clavulanic acid cross the placental barrier. However, no negative effects on the fetus were detected.

Amoxicillin is eliminated primarily by the kidneys, while clavulanic acid is eliminated through both renal and extrarenal mechanisms. After a single oral dose of 875 mg/125 mg or 500 mg/125 mg, approximately % amoxicillin and % clavulanic acid are excreted unchanged by the kidneys during the first 6 hours.

The average half-life (T1/2) of amoxicillin/clavulanic acid is approximately 1 hour, and the average total clearance is approximately 25 L/h in healthy patients. In various studies, it was found that renal excretion of amoxicillin within 24 hours is approximately %, clavulanic acid - %.

The largest amount of clavulanic acid is excreted during the first 2 hours after administration.

The pharmacokinetics of amoxicillin/clavulanic acid does not depend on the gender of the patient.

Patients with impaired renal function

The total clearance of amoxicillin/clavulanic acid decreases in proportion to the decrease in renal function. The decrease in clearance is more pronounced for amoxicillin than for clavulanic acid, because Most amoxicillin is excreted by the kidneys. Doses of the drug for renal failure should be selected taking into account the undesirability of amoxicillin accumulation while maintaining normal levels of clavulanic acid.

Patients with liver dysfunction

In patients with impaired liver function, the drug is used with caution. It is necessary to constantly monitor liver function.

Both components are removed by hemodialysis and minor amounts by peritoneal dialysis.

Indications for use

Infectious and inflammatory diseases caused by microorganisms sensitive to amoxicillin + clavulanic acid:

• infections of the upper respiratory tract and ENT organs (acute and chronic sinusitis, acute and chronic otitis media, retropharyngeal abscess, tonsillitis, pharyngitis);

• lower respiratory tract infections (acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia);

• urinary tract infections (eg cystitis, urethritis, pyelonephritis);

• infections in gynecology;

• skin and soft tissue infections, including animal and human bites;

• infections of bone and connective tissue;

• biliary tract infections (cholecystitis, cholangitis);

Contraindications

• hypersensitivity to any of the components of the drug;

• history of hypersensitivity to penicillins, cephalosporins and other β-lactam antibiotics;

• a history of indications of cholestatic jaundice and/or impaired liver function caused by taking amoxicillin/clavulanic acid;

With caution: with a history of pseudomembranous colitis, diseases of the gastrointestinal tract, liver failure, severe renal impairment, pregnancy, lactation, when used simultaneously with anticoagulants.

Use during pregnancy and breastfeeding

Animal studies have not revealed any evidence of harm from taking the drug during pregnancy or its effect on the embryonic development of the fetus.

One study of women with premature rupture of membranes found that amoxicillin/clavulanic acid prophylaxis may be associated with an increased risk of necrotizing enterocolitis in the newborn.

During pregnancy and lactation, the drug is used only if the expected benefit to the mother outweighs the potential risk to the fetus and child.

Amoxicillin and clavulanic acid pass into breast milk in small quantities, so taking the drug during breastfeeding should be continued only if there are clear indications.

Infants who are breastfed may develop sensitization, diarrhea, and candidiasis of the oral mucosa. In such cases, breastfeeding should be stopped.

Directions for use and doses

The dosage regimen is set individually depending on the age, body weight, kidney function of the patient and the severity of the infection.

Daily dose of suspensions 125 mg+31.25 mg/5 ml and 250 mg+62.5 mg/5 ml

(to facilitate correct dosing, each package of suspensions 125 mg + 31.25 mg/5 ml and 250 mg + 62.5 mg/5 ml includes a dosing pipette graduated to 5 ml with a division scale of 0.1 ml or a dosing spoon with a capacity of 5 ml, with ring marks in the cavity at 2.5 ml and 5 ml).

Newborns and children up to 3 months:

30 mg/kg (amoxicillin) per day, divided into 2 doses (every 12 hours).

Dosing of the drug Amoxiclav ® with a dosage pipette: calculation of single doses for the treatment of infections in newborns and children up to 3 months:

ml (2 times a day)

ml (2 times a day)

Children over 3 months:

From 20 mg/kg for mild and moderate infections to 40 mg/kg for severe infections and lower respiratory tract infections, otitis media, sinusitis (according to amoxicillin) per day, divided into 3 doses (every 8 hours).

Dosing of the drug Amoxiclav ® with a dosage pipette: calculation of single doses for the treatment of mild and moderate infections in children over 3 months (at the rate of 20 mg/kg body weight per day (for amoxicillin):

Dosing of the drug Amoxiclav ® with a dosage pipette: calculation of single doses for the treatment of severe infections in children over 3 months (at the rate of 40 mg/kg body weight per day (for amoxicillin):

Dosing of the drug Amoxiclav ® with a dosing spoon (in the absence of a dosing pipette): recommended doses of suspensions depending on the child’s body weight and the severity of the infection

Daily dose of suspension 400 mg+57 mg/5 ml

The dose is calculated per kg of body weight depending on the severity of the infection. From 25 mg/kg for mild and moderate infections to 45 mg/kg for severe infections and lower respiratory tract infections, otitis media, sinusitis (in terms of amoxicillin) per day, divided into 2 doses.

To facilitate correct dosing, a dosage pipette is inserted into each package of the 400 mg + 57 mg/5 ml suspension, graduated simultaneously into 1, 2, 3, 4, 5 ml and into 4 equal parts.

Suspension 400 mg+57 mg/5 ml is used in children over 3 months.

Recommended dose of suspension depending on the child’s body weight and severity of infection

The maximum daily dose of amoxicillin is 6 g for adults and 45 mg/kg for children.

The maximum daily dose of clavulanic acid (in the form of potassium salt) is 600 mg for adults, 10 mg/kg body weight for children.

In patients with impaired renal function, the dose should be adjusted based on the maximum recommended dose of amoxicillin.

Patients with CC more than 30 ml/min do not require any dose adjustment.

Adults and children weighing more than 40 kg (the indicated dosage regimen is used for moderate and severe infections)

For patients with creatinine clearance/min 500 mg/125 mg twice daily.

For CC less than 10 ml/min, the recommended dose is 500 mg/125 mg once a day.

For patients on hemodialysis, the recommended dose is 500 mg/125 mg every 24 hours plus 500 mg/125 mg during the dialysis session and another dose at the end of the dialysis session (as serum concentrations of amoxicillin and clavulanic acid are reduced).

Children weighing less than 40 kg

For CCml/min, the recommended dose is 15 mg/3.75 mg/kg twice daily (maximum 500 mg/125 mg twice daily).

For CC less than 10 ml/min, the recommended dose is 15 mg/3.75 mg/kg once daily (maximum 500 mg/125 mg).

For hemodialysis, the recommended dose is 15 mg/3.75 mg/kg once daily. Before hemodialysis 15 mg/3.75 mg/kg. To restore appropriate concentrations of the drug in the blood, it is necessary to take another dose of 15 mg/3.75 mg/kg after hemodialysis.

The course of treatment is 5–14 days. The duration of treatment is determined by the attending physician. Treatment should not continue for more than 14 days without reviewing the clinical situation.

Instructions for preparing the suspension

Powder for preparing a suspension 125 mg + 31.25 mg/5 ml: shake the bottle vigorously, add 86 ml of water in two additions (to the mark), shaking well each time until the powder is completely dissolved.

Powder for preparing a suspension 250 mg + 62.5 mg/5 ml: shake the bottle vigorously, add 85 ml of water in two additions (to the mark), shaking well each time until the powder is completely dissolved.

Powder for preparing a suspension 400 mg + 57 mg/5 ml: shake the bottle vigorously, add water in two doses (to the mark) in the amount indicated on the label and given in the table, shaking well each time until the powder is completely dissolved.

Shake vigorously before use!

To prepare the suspension, it is recommended to dilute the powder with boiled water at room temperature.

It is recommended to place the finished suspension in the refrigerator.

It is not recommended to heat the suspension before use (it is necessary to bring the suspension to room temperature).

After taking the drug, it is recommended to rinse the dosage pipette with boiled water.

Side effect

According to the World Health Organization (WHO), adverse reactions are classified according to their frequency of development as follows: very common (>1/10), common (>1/100, <1/10), not common (>1/1000, <1/100), rare (>1/10000, <1/1000) and very rare (<1/10000); frequency unknown - based on available data, it was not possible to determine the frequency of occurrence.

From the hematopoietic organs and lymphatic system

rarely: reversible leukopenia (including neutropenia), thrombocytopenia;

very rare: eosinophilia, thrombocytosis, reversible agranulocytosis, increased bleeding time and reversible increase in prothrombin time, anemia, including reversible hemolytic anemia.

From the immune system

very rare: angioedema, anaphylactic reactions, allergic vasculitis, a syndrome similar to serum sickness.

From the nervous system

uncommon: dizziness, headache;

very rarely: insomnia, agitation, anxiety, behavior changes, reversible hyperactivity, convulsions; seizures may occur in patients with impaired renal function, as well as in those receiving high doses of the drug.

From the gastrointestinal tract

often: loss of appetite, nausea, vomiting, diarrhea;

Nausea is more common when taking high doses orally. If gastrointestinal disorders are confirmed, they can be eliminated if the drug is taken at the beginning of a meal.

uncommon: indigestion;

very rare: antibiotic-associated colitis induced by antibiotics (including pseudomembranous and hemorrhagic colitis), black “hairy” tongue, gastritis, stomatitis.

Children very rarely experienced discoloration of the surface layer of tooth enamel. Oral care helps prevent tooth enamel from discoloring.

From the skin

uncommon: skin rash, itching, urticaria;

rarely: exudative erythema multiforme;

very rare: Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous exfoliative dermatitis, acute generalized exanthematous pustulosis.

From the urinary system

very rarely: crystalluria, interstitial nephritis, hematuria.

From the liver and biliary tract

uncommon: increased activity of alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST); (This phenomenon has been observed in patients receiving beta-lactam antibiotic therapy, but its clinical significance is unknown).

Adverse liver events have been observed primarily in men and elderly patients and may be associated with long-term therapy. These adverse events are very rarely observed in children.

The listed signs and symptoms usually occur during or immediately after completion of therapy, but in some cases they may not appear for several weeks after completion of therapy. Adverse effects are usually reversible.

Adverse liver events can be severe, and deaths have been reported in extremely rare cases. In almost all cases, these were persons with serious comorbidities or persons receiving concomitantly potentially hepatotoxic drugs.

very rarely: increased alkaline phosphatase levels, increased bilirubin levels, hepatitis, cholestatic jaundice (noted during concomitant therapy with other penicillins and cephalosporins).

often: candidiasis of the skin and mucous membranes;

frequency unknown: growth of non-susceptible microorganisms.

Overdose

There are no reports of death or life-threatening side effects due to an overdose of Amoxiclav ®.

Symptoms of overdose include gastrointestinal disorders (abdominal pain, diarrhea, vomiting) and water and electrolyte imbalance. There have been reports of crystalluria caused by amoxicillin, which, in some cases, led to the development of renal failure.

Convulsions may develop in patients with renal failure or in patients receiving high doses of the drug.

In case of overdose, the patient should be under medical supervision and treatment should be symptomatic.

In case of overdose of the drug, gastric lavage and taking adsorbents (activated carbon) are recommended.

Amoxicillin/clavulanic acid is eliminated by hemodialysis.

Interaction with other drugs

Antacids, glucosamine, laxatives, aminoglycosides slow down absorption, ascorbic acid increases absorption.

Diuretics, allopurinol, phenylbutazone, non-steroidal anti-inflammatory drugs and other drugs that block tubular secretion (probenecid) increase the concentration of amoxicillin (clavulanic acid is eliminated mainly by glomerular filtration).

The simultaneous use of Amoxiclav ® and methotrexate increases the toxicity of methotrexate.

Prescription together with allopurinol increases the incidence of exanthema. Concomitant use with disulfiram should be avoided.

Reduces the effectiveness of drugs, during the metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol - the risk of developing “breakthrough” bleeding.

Increases the effectiveness of indirect anticoagulants (suppressing intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index). When taking anticoagulants simultaneously, it is necessary to monitor blood clotting indicators.

The literature describes rare cases of an increase in the international normalized ratio (INR) in patients with the combined use of acenocoumarol or warfarin and amoxicillin.

If simultaneous use with anticoagulants is necessary, prothrombin time or INR should be carefully monitored when prescribing or discontinuing the drug.

The combination with rifampicin is antagonistic (mutual weakening of the antibacterial effect). The drug Amoxiclav ® should not be used simultaneously in combination with bacteriostatic antibiotics (macrolides, tetracyclines), sulfonamides due to a possible decrease in the effectiveness of the drug Amoxiclav ® .

In patients receiving mycophenolate mofetil, after starting the combination of amoxicillin with clavulanic acid, a decrease in the concentration of the active metabolite, mycophenolic acid, was observed before taking the next dose of the drug by approximately 50%. Changes in this concentration may not accurately reflect overall changes in mycophenolic acid exposure.

The drug Amoxiclav ® reduces the effectiveness of oral contraceptives.

special instructions

Before starting treatment, it is necessary to interview the patient to identify a history of hypersensitivity reactions to penicillins, cephalosporins or other β-lactam antibiotics.

In patients who are hypersensitive to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible. During a course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver, and kidneys.

In patients with severely impaired renal function, adequate dose adjustment or increased intervals between doses is required.

In order to reduce the risk of side effects from the gastrointestinal tract, the drug should be taken with meals.

Superinfection may develop due to the growth of microflora insensitive to amoxicillin, which requires a corresponding change in antibacterial therapy.

If antibiotic-associated colitis occurs, Amoxiclav ® should be immediately discontinued, consult a doctor and begin appropriate treatment. Drugs that inhibit peristalsis are contraindicated in such situations.

Treatment must continue after the disappearance of clinical signs of the disease. When using estrogen-containing oral contraceptives and amoxicillin simultaneously, other additional methods of contraception should be used if possible.

Amoxicillin and clavulanic acid can provoke nonspecific binding of immunoglobulins and albumins to the erythrocyte membrane, which can cause a false positive reaction with the Coombs test.

Crystalluria very rarely occurs in patients with reduced diuresis. During the use of large doses of amoxicillin, it is recommended to take sufficient fluids and maintain adequate diuresis to reduce the likelihood of amoxicillin crystal formation.

The use of the drug should be avoided if infectious mononucleosis is suspected.

Laboratory tests: High concentrations of amoxicillin give a false-positive reaction to urine glucose when using Benedict's reagent or Fehling's solution.

It is recommended to use enzymatic reactions with glucosidase.

Special precautions when disposing of unused medicinal product

There is no need for special precautions when disposing of unused Amoxiclav ® .

Impact on the ability to drive vehicles and machinery

There is no data on the negative effect of the drug Amoxiclav ® in recommended doses on the ability to drive a car or operate machinery. However, due to the possibility of developing side effects from the central nervous system, such as dizziness, headache, convulsions, during treatment you should be careful when driving and engaging in other activities that require concentration and speed of psychomotor reactions.

If the described adverse events occur, you should refrain from performing these activities.

Release form

Powder for suspension for oral administration

For dosages of 125 mg + 31.25 mg/5 ml and 250 mg + 62.5 mg/5 ml:

Primary packaging: 25 g of powder (100 ml of finished suspension) in a dark glass bottle with a ring mark (100 ml). The bottle is closed with a screw cap made of high-density polyethylene with a control ring and a cone seal inside the cap or a screw-on metal cap with a control ring, inside the cap there is a gasket made of low-density polyethylene.

One bottle each with a dosage spoon with ring markings in the cavity for 2.5 ml and 5 ml (“2.5 SS” and “5 SS”), a maximum filling mark of 6 ml (“6 SS”) on the handle of the spoon and instructions for for medical use in a cardboard box.

One bottle along with a graduated dosage pipette and instructions for medical use in a cardboard box.

For dosage 400 mg + 57 mg/5 ml:

Primary packaging: 8.75 g (35 ml of ready suspension), 12.50 g (50 ml of ready suspension), 17.50 g (70 ml of ready suspension) or 35.0 g (140 ml of ready suspension) powder in a dark bottle glass with a screw cap made of high density polyethylene with a control ring and a cone seal inside the cap.

17.50 g (70 ml of ready-made suspension) in a dark glass bottle with a ring mark (70 ml) with a high-density polyethylene screw cap with a control ring and a cone seal inside the cap.

One bottle along with a graduated dosage pipette and instructions for medical use in a cardboard box.

Storage conditions

Store in a dry place at a temperature not exceeding 25°C.

The prepared suspension is stored at a temperature of 2-8 ° C in a tightly closed bottle.

Keep out of the reach of children!

Best before date

Ready suspension – 7 days.

Do not use the drug after the expiration date indicated on the package!

Vacation conditions

Manufacturer

Lek d.d., Verovškova 57, 1526 Ljubljana, Slovenia.

Consumer complaints should be sent to Sandoz CJSC:

125315, Moscow, Leningradsky Prospekt, 72, bldg. 3.

Source: http://medi.ru/instrukciya/amoksiklav-suspenziya_5715/

Amoxiclav dosage for children

Every mother, when treating her child, tries to choose the most effective and most harmless medicine for this. But if you are affected by a viral infection, you cannot do without an antibiotic, and most often it is recommended to use the drug Amoxiclav for children. Before use, be sure to familiarize yourself with its composition, dosage, possible side effects and contraindications.

To help young parents, in this article we will figure out whether Amoxiclav can be given to children and how to give it to a child correctly, as well as what indications exist for the use of this drug.

Composition of Amoxiclav

This is a combined antibiotic with a wide spectrum of action, the main components of which are semisynthetic penicillin Amoxicillin and clavulanic acid. Thanks to them, the drug has strong antibacterial properties against many gram-positive and gram-negative representatives of microflora. The medicine begins to act in approximately an hour.

For ease of use by young children, Amoxiclav is available in syrup, suspension, drops, and for older adults (after 14 years) - in tablets. To prepare the suspension, add 85 ml of cold water to the lyophilisate powder and mix well. It can only be stored for a week in the refrigerator. In other forms of release, you can take it immediately.

Application of Amoxiclav

Amoxiclav can be used to treat children with:

  • sore throat and other diseases in the upper respiratory tract;
  • sinusitis of varying degrees;
  • bronchitis, pneumonia;
  • otitis;
  • diseases of the urinary system;
  • infectious diseases of the skin, bones or joints;
  • infections in the bile ducts.

Dosage of Amoxiclav for children

The duration of treatment usually ranges from 5 days to 2 weeks, but be sure to follow the dosages developed for different age groups, taking every 8 hours, that is, a maximum of 3 times a day:

  1. For children under one year old, Amoxiclav can be given ½ teaspoon (this is approximately 2.5 ml).
  2. Children from 1 year to 7 years – 1 teaspoon or 5 ml.
  3. From 7 to 14 years old – 2 teaspoons or 10 ml.

In severe cases of the disease, single doses can be used to more quickly stabilize the patient’s condition:

  • up to 3 months - at the rate of 30 mg per kilogram of the child’s weight 2 times a day;
  • up to 12 years - the same dose calculation, but given 3 times a day;
  • after 12 years – 1.2 g – 3 times a day.

The dosage of Amoxiclav Forte suspension for children can be reduced by half from that indicated above.

Contraindications for the use of Amoxiclav

Despite the fact that Amoxiclav is a gentle antibiotic, there are diseases for which it cannot be used. This:

  • Infectious mononucleosis;
  • lymphocytic leukemia;
  • liver and kidney failure;
  • cholestatic hepatitis.

And, of course, if you are intolerant to one of the components of the drug.

Side effects after Amoxiclav

Pediatricians and parents did not observe particularly pronounced negative consequences after using this antibiotic, but you need to know that the following may occur:

They are quite rare, but if you combine Amoxiclav with food, and also take antihistamines and probiotics at the same time, you can completely avoid them.

Under no circumstances should you prescribe Amoxiclav to your child yourself, because you will not be able to correctly calculate the required dosage. Therefore, before you start giving it, you should consult a doctor and discuss with him the issue of the advisability of using this drug.

Source: http://www.my-sunshine.ru/suspenziya-amoksiklav-dlya-detei