What is dioxidin in ampoules for?

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Dioxidin: instructions for use

Dioxidine is an antibacterial drug from the group of quinoxaldine derivatives.

It has bactericidal and antibacterial effects on various pathogens: Pseudomonas aeruginosa, staphylococci, pathogenic anaerobes and other strains of bacteria resistant to other antibiotics.

Table of contents:

It is usually used in a hospital setting for the treatment of septic conditions, as it is a reserve antibacterial drug. Its effectiveness is combined with high toxicity, so the drug is prescribed only if treatment with other, less toxic antibiotics fails.

On this page you will find all the information about Dioxidin: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Dioxidin in ampoules. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibacterial drug, quinoxaline derivative.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

How much does Dioxidin cost? The average price in pharmacies is 300 rubles.

Release form and composition

Dioxidin has several forms of release:

  • ointment 5%;
  • Dioxidine solution (0.5%) for intravenous injection;
  • Dioxidine in ampoules for inhalation (5 mg) and intracavitary use (1%).

Dioxidin 1% solution is available in 10 ml glass ampoules. 1 ml of a clear, colorless solution contains 10 mg of the active ingredient dissolved in water for injection.

Dioxidin 5 mg for inhalation is produced in ampoules of 10 and 20 ml. In each milliliter of the drug in water for injection, 5 mg of hydroxymethylquinoxaline dioxide is dissolved. Ampoules containing solution for injection and inhalation are placed in 10 pieces in cardboard packages.

Pharmacological effect

Dioxidin is a synthetic bactericidal agent that is used in the treatment of purulent and infectious pathologies. Usually the drug is used externally, however, if necessary, intracavitary lavage and intravenous administration are allowed.

Dioxidin has a detrimental effect on pathogenic cells by inhibiting the formation of DNA, but does not affect the production of RNA and protein. Also, the main active ingredient destroys the microbiological structure (shell and nucleotides, which play an important role in the formation of intracellular energy).

The drug is widely used in medicine due to its effective suppression of pathogenic flora in anoxic conditions.

Indications for use

According to the instructions, Dioxidin is indicated for use in bacterial infections that are sensitive to the active component of the drug.

External use of Dioxidin is advisable in the following cases:

  1. Infected burns;
  2. Soft tissue phlegmon;
  3. Deep or superficial wounds on the body;
  4. Trophic ulcers and long-term non-healing wounds;
  5. Purulent wounds with osteomyelitis.

Intracavitary administration of Dioxidin is indicated in the following cases:

  1. Peritonitis;
  2. Abscesses;
  3. Purulent pleurisy;
  4. Purulent processes in the abdominal or thoracic cavity;
  5. Wounds of the biliary and urinary tract;
  6. Pleural empyema;
  7. Wounds and phlegmon with the presence of deep purulent cavities (pelvic cellulitis, soft tissue abscesses, purulent mastitis, postoperative wounds of the biliary and urinary tract).

Contraindications

Dioxidin is contraindicated for:

  • individual intolerance to the drug;
  • dysfunction of the adrenal glands;
  • pregnancy and lactation;
  • under 12 years of age.

Despite the obvious positive effect of the drug in the treatment of purulent-microbial pathologies, the high toxicity of dioxidin has determined it to be a reserve drug, especially for intravenous infusions.

Use during pregnancy and lactation

The effect of hydroxymethylquinoxylin dioxide on the body has been studied over many years of research. As a result, its mutagenic and teratogenic effects were reliably established.

Women at any stage of pregnancy should not be prescribed this drug, and not only intravenously or into the body cavity. Even local use in the form of ointments, compresses or nasal drops ensures the penetration of the active substance into the bloodstream through the mucous membranes and skin. For the same reason, treatment with Dioxidin during lactation is excluded (a temporary transition to pumping and artificial feeding is usually recommended).

Instructions for use

The instructions for use indicate that Dioxidin is most often used in hospital settings. A 1% solution of the drug is usually not used for intravenous injection (due to the instability of the drug when stored at low temperatures). Use 0.1-1% solutions, for which the drug is diluted with water for injection or sodium chloride solution.

External use of Dioxidin:

  1. To prevent infections after operations, Dioxidin is used in the form of a 0.1-0.5% solution.
  2. When treating superficial infected purulent wounds, wipes soaked in a 0.5-1% solution of Dioxidin are applied to the wound. When treating deep wounds, they are loosely tamponed with tampons pre-moistened in a 1% solution. If there is a drainage tube, a 0.5% solution, from 20 to 100 ml, is injected into the cavity.
  3. For the treatment of deep purulent wounds with osteomyelitis - in the form of baths with a 0.5-1% solution. Less commonly, special treatment of the wound is carried out by injecting the drug for a minute, then apply a bandage with a 1% solution of Dioxidine. If the drug is well tolerated, treatment can be carried out daily for 1.5-2 months.
For intracavitary administration, a catheter, syringe or drainage tube is used. A 1% solution of the drug is injected into the purulent cavity; the dose depends on the size of the cavity, usually ml per day. Usually the drug is administered once a day. The maximum daily dose is 70 ml. Treatment can be continued for three weeks or more if indicated and well tolerated.

Instructions for use of Dioxidin in the nose

Dioxidin solution is used in the presence of complicated inflammatory processes in the nasal cavity, in particular for the treatment of sinusitis, sinusitis, frontal sinusitis and other pathologies. The nasal cavity is washed with Dioxidin solution 2-3 times a day, using a syringe for convenience.

The drug has an excellent therapeutic effect in complicated sinusitis, when other drugs, including antibiotics, are ineffective. The punctured maxillary sinuses are washed with a solution of the drug 2-3 times a day, after which, if necessary, gauze turundas soaked in the solution are inserted into the nasal cavity.

Dioxin in the ear

To treat otitis media, it is usually customary to use antibiotics and vasoconstrictor drugs. However, in cases where they are not effective, Dioxidin becomes the drug of choice, a feature of which is its effectiveness against anaerobic bacteria.

Before instilling the medicine, it is recommended to clean the ear canal from wax using a cotton swab soaked in a 3% hydrogen peroxide solution or special cotton swabs (for convenience, the auricle is slightly pulled back). If the ear is very dirty, leave the tampon with peroxide in it for about 5 minutes.

  1. In case of purulent otitis media, which is often accompanied by perforation of the eardrum and discharge of pus, all purulent contents are first removed from the ear canal before instillation.
  2. For otitis, Dioxidin should be injected simultaneously into the nose and into the ear canal. The solution effectively sanitizes the nasal cavity and stops the inflammatory process in it, and since the nose is connected to the ear by the Eustachian tube, relieving the inflammatory process in the nose has a beneficial effect on the situation as a whole.

The dose and frequency of instillations are selected individually in each specific case and exclusively by the attending physician.

Dioxidin ointment

Used to treat purulent wounds, trophic ulcers, phlegmon, wounds with osteomyelitis, pustular skin rashes. Apply a thin layer to the surface of the skin, and insert tampons with ointment into the purulent wounds. The daily dose for adults should not be more than 2.5 g. The duration of use of the product is 3 weeks.

Inhalation with a nebulizer

Today, a nebulizer is popular in the treatment of coughs and runny noses. However, not all owners of a useful device know which solutions are suitable for inhalation and which are not. What doctors say about the use of Dioxidin in nebulizers and inhalers.

The solution can be used at home, but under strict control of the dosage of Dioxidin. Inhalations are prescribed for lung abscesses, pleural empyema, severe inflammation of the bronchi. Dioxidin is rarely prescribed for sinusitis, frontal sinusitis, sinusitis - in case of protracted course of the disease and the appearance of resistance (immunity) to other (weaker) drugs.

The concentrated solution is not poured into the nebulizer; it is diluted with saline solution. How to dilute Dioxidin correctly?

  • ampoules with a 1% solution are diluted in a ratio of 1:4;
  • ampoules with a 0.5% solution are diluted in a ratio of 1:2.

One inhalation will require 3 ml. What is left can be stored in the refrigerator for no more than 12 hours. The only point is that before inhalation, Dioxidin should be removed from the refrigeration chamber so that it warms up naturally. The solution must not be heated!

Side effects

Dioxidin when administered intracavitarily can cause:

  • dyspeptic disorders;
  • convulsive muscle contractions;
  • allergic reactions;
  • headache;
  • chills;
  • rising temperatures;
  • photosensitizing effect (appearance of pigmented spots on the body when exposed to sunlight);
  • periwound dermatitis (for external use).

When used externally, Dioxidin can cause periwound dermatitis.

Overdose

Symptoms of overdose include both excessive symptoms from the list of side effects and acute insufficiency of adrenal cortex function:

  1. To cope with the difficulty of synthesizing corticosteroids (stress hormones), therapy must be stopped.
  2. For other manifestations of overdose, therapeutic methods are selected - symptomatic treatment.

Hormone replacement therapy is allowed - in the form of doses of glucocorticosteroids determined by the doctor (normally - up to 1 mg per kilogram of the patient’s weight).

special instructions

  1. The drug is prescribed only if other antibacterial drugs are ineffective, including fluoroquinolones, cephalosporins of II-IV generations, carbapenems.
  2. Before starting to use Dioxidin, a drug tolerability study must be carried out. To do this, a small volume (10 ml) of a 1% solution is injected into the cavities and the patient’s condition is monitored for 3-6 hours. If no side effects (chills, fever, dizziness) occur during this time, the drug can be used for a course of treatment.
  3. If pigment spots occur, increase the duration of a single dose to 1.5-2 hours, reduce the dose, discontinue dioxidine or prescribe antihistamines.

Reviews

We have selected some people's reviews about the drug Dioxidin:

  1. Elena . I usually use dioxidine solution to treat a persistent runny nose in my child. I mix it in equal parts with aloe extract and drip twice a day. The product is cheap and very effective. Does not dry out the mucous membranes and does not cause discomfort.
  2. Anna . One day in early spring I began to feel stuffy in my ears. I tried traditional methods of treatment, but the disease only worsened. The otolaryngologist prescribed dioxidine drops. At the same time, the doctor assured that the drug has absolutely no side effects. Having instilled the maximum dose of the drug into the auricle, I felt a burning sensation. After that, I read the instructions and discovered a large number of side effects. For treatment, I reduced the dose and quickly cured the inflammation of the ear canal. I recommend this drug to everyone, but read the instructions carefully before using it.
  3. Tanya. Dioxidin is a very good medicine. I only use it for mixed drops, for the nose. For a runny nose that I can’t cure for more than a week or two, this is an indispensable remedy! The ENT doctor prescribed it to me and said that even sinusitis can be treated with mixed drops, and patients don’t have to pierce their sinuses. Here is the recipe: Dioxidin 1% - 5 ml, Mezaton - 2 ml, Dexamethasone - 2 ml = mix everything in 10 cubic meters. syringe, and drip 2 drops, 3 times a day. The nose breathes, and the runny nose goes away very quickly. The price is affordable, even very, and you can find this drug in all pharmacies.
  4. Sasha . For furunculosis, I was prescribed Dioxidin in ampoules, which I placed on gauze rolled up in several layers, which I dipped into a printed ampoule of solution to the place where the boil broke out. Surgeons said that this medicine is an antibiotic and sucks out pus well. In principle, he did his own work for his own money and the wounds were cleared of pus quickly, faster than before, when they simply changed the bandages or applied Ichthyol ointment.

Analogs

What analogues of Dioxidin can be found in pharmacies?

  1. Dioxysept. Identical to Dioxidin in all respects: action, method of application, indications, side effects.
  2. Dioxicol. Available in the form of an ointment. In addition to Dioxidin, it contains Trimecain, Methyluracil, and Polyethylene oxide. It is well tolerated and causes virtually no side effects.
  3. Urotravenol. Consists of Dioxidine, Glycine and water. Supplied in sterile 10 liter containers. Used in hospitals for intracavitary administration.
  4. Quinoxidine. Essentially, this drug is a tablet form of Dioxidin. Prescribed for multidrug-resistant urinary tract infections. It is characterized by a high frequency of side effects from the digestive system.

Before using analogues, consult your doctor.

Storage conditions and shelf life

On average, the drug has a long shelf life (3 years), less often – 24 months. Any form (ointment, ampoules) is available only with a prescription. Storage conditions:

  • in a safe place, out of reach of children;
  • at a temperature of degrees;
  • in a dry place protected from light.

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2 comments

Dioxidin is the best and most effective antimicrobial drug created in the history of medicine. Quickly inactivates almost all pathogenic microorganisms known to science, including some protozoa, and without side effects. If the recommended dosages are followed, local, intracavitary use does not cause any toxic effects.

Particularly effective for the treatment of bacterial infections of the respiratory tract in immunocompromised individuals by instillation into the nose, inhalation of a 1% solution using a pocket inhaler and rinsing the maxillary sinuses. The effectiveness has been proven many times personally for me and many others. Dioxidin is a Russian miracle that has almost no analogues abroad. Thanks to the developers and Soviet science.

I suffer from chronic sinusitis, often exacerbations especially against the background of severe colds. At the clinic, the ENT doctor advised, in addition to traditional antibiotic tablets, to use the antibacterial agent Dioxidin by instilling it directly into the nose.

First you need to clear your nose (if it is clogged) using some vasoconstrictor (Xylene, Rinostop, Nazivin, etc.), then take an ampoule of a 1% solution and drop 2 drops into each nostril 3 times a day.

You can use a syringe or pipette for this. Sometimes there may be temporary mild discomfort - a burning sensation in the nose or tingling, but this does not last long. I can say for sure – it helps 100%.

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Dioxidin in ampoules: instructions for use

Dioxidin in ampoules is an antibacterial drug that has a wide range of applications in otolaryngology. Prescribe Dioskidin in the nose for bacterial damage to the mucous membrane of the nasopharynx and paranasal sinuses. The drug is capable of acting on strains of bacteria that not every antibiotic can destroy.

Dioxidin in ampoules: instructions for use

Composition of Dioxidine: hydroxymethylquinoxylin dioxide.

Instructions for use of Dioxidin:

  • used for purulent lesions, both for external use (for tropical ulcers, non-healing wounds, purulent wounds) and for intracavitary use (for purulent lesions of the nasopharynx, chest cavity).

Dioxidin in ampoules must be diluted in the required proportion with water for injection, and a solution of Dioxidin with sodium chloride is also possible. The dosage of the solution is prescribed by the attending physician on an individual basis.

Contraindications include:

  • pregnancy;
  • lactation period;
  • age under 18 years;
  • renal failure;
  • individual intolerance to components.

Possible side effects when using the drug:

  • Strong headache;
  • chills;
  • convulsions;
  • increased body temperature;
  • the appearance of pigment spots;
  • development of allergic reactions;
  • nausea;
  • gagging;
  • diarrhea;
  • dermatitis.

The use of Dioxidin in ampoules is permitted exclusively in hospital settings.

Dioxidin 1% in the nose: instructions for use

Dioxidin in the nose is not available in the form of drops, so many people have a reasonable question - how to instill an antibiotic into the nose?

First of all, Dioxylin 1% must be diluted in saline solution. Proportion 1/4. You can then change the solution in one of the following ways:

Washing method. Using a pipette, the required amount of solution is poured into the patient’s nostril, while the patient must be in a lying position. After a second, you need to blow your nose, and only after that you can do the same procedure with the second nostril.

Instillation method. The patient tilts his head back and injects three drops of solution into each nostril. Repeat the procedure three times a day.

Inhalation method. Carry out the inhalation procedure twice a day, dissolving no more than 8 ml in a nebulizer.

Please note that precise recommendations on how to dilute Dioxidin should be given to the patient by a medical professional!

Dioxidin for sinusitis

Sinusitis is a serious pathology of the sinuses and requires urgent action. Despite the fact that the instructions do not describe Dioxidine as an indication for the treatment of this disease, the antibiotic is used to rinse the sinuses. Below we describe how to use Dioxidin for sinusitis.

First of all, it should be noted that the drug is highly toxic and is used extremely rarely and only in a hospital. For sinusitis, Dioxidin is prescribed for severe forms of the disease, with profuse purulent discharge and lack of response to more gentle treatments. The doctor punctures the sinuses and then rinses the cavity with the drug.

It is also approved for use before and after surgery.

Dioxidin: analogues of the drug

The price of Dioxidin is quite high: ampoules containing one percent of the drug cost about 450 rubles. This cost may be unacceptable to consumers with financial difficulties. In addition, the drug is highly toxic, has strict restrictions on use and belongs to the list of B drugs (potent, dispensed in pharmacies strictly as prescribed by a doctor). It will be more appropriate to select analogues.

Dioxidin analogues are presented in the following list:

  • Quinoxidine. A broad-spectrum antimicrobial drug, one of the main enemies of purulent lesions of the mucous membranes, is available in the form of tablets. Approved for use from 18 years of age.
  • Evamenol. Natural extract based on menthol, eucalyptus oil, petroleum jelly. Actively fights the runny nose, rhinitis, swelling, and increases the outflow of mucus. It comes in the form of an ointment that can be applied to a cotton swab and applied to the nasal passage. Allowed for use by children from the age of two.
  • Malavit. It is based exclusively on natural and herbal ingredients. A powerful antiseptic, available in the form of drops and used to treat sinusitis, sinusitis, and rhinitis. Malavit is affordable and safe to use; contraindications include only individual intolerance to the components.
  • Eucasept. Another natural analogue of hydroxymethylquinoxyline dioxide. The composition is based on essential oils of eucalyptus, fir and mint. Actively fights bacteria in the nasal cavity, has an antiseptic, anti-inflammatory and vasoconstrictor. Contraindications include: children under two years of age and an allergic reaction to the components that make up Eucasept.

Please note that any drug should be used only as prescribed by your doctor!

Dioxidin: antibiotic or not?

Dioxidin is no longer an antibiotic, but a broad-spectrum antiseptic. Synthetic substance with antibacterial properties. Allows you to fight viruses that direct antibiotics often cannot cope with.

How to store an open ampoule of Dioxidine

An open ampoule of Dioxidin can be stored for no more than a day. Storage space is exclusively in the refrigerator.

Refrain from using this antibacterial agent yourself! Use only as directed and under the supervision of a doctor!

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Source: http://gaimoritstop.ru/dioksidin.html

Dioxidin is a “heavy” drug that is often prescribed to children. Is it worth the risk or is it better to look for an alternative...

Dioxidin is an antibacterial drug that was actively used in hospitals during Soviet times. Today it is also used, but without fanaticism and with good reason. Indeed, Hydroxymethylquinoxyline dioxide (this is what the international nonproprietary name of Dioxidine sounds like) in large doses has a high degree of toxicity, which means it requires a competent and balanced approach when prescribing.

Before you continue reading: If you are looking for an effective method of getting rid of a runny nose, pharyngitis, tonsillitis, bronchitis or colds, then be sure to look at this section of the site after reading this article. This information has helped so many people, we hope it will help you too! So, now back to the article.

What kind of “beast” is Dioxidin?

In the middle of the last century, a potent substance with a long “name” enjoyed success in many hospitals in the country. The base is a yellow-green, odorless powder. The bactericidal agent destroys the membranes of harmful cells and prevents their proliferation.

The success of the medication among Soviet doctors was explained by its high efficiency in eliminating microorganisms that cause purulent processes. A powerful antiseptic easily copes with streptococci, staphylococci, Pseudomonas aeruginosa and pathogenic anaerobes.

The ability to fight pathogens that develop without the participation of oxygen distinguishes Dioxidin from other antibacterial drugs. By the way, scientists have not yet been able to determine how he does this. It is only known that the drug prevents the formation of DNA and disrupts the structure of enemy cells.

What do the studies say?

Clinical trials were conducted in 24 different hospitals. In total, the experiments lasted 15 years. The results were impressive. The studies involved patients with severe infections that could not be treated with antibiotics. The use of 0.5%, 0.1%, and 1% Dioxidin in patients with purulent pathologies of the urinary system, ENT organs, burns, and osteomyelitis gave a positive result in 85% of cases.

Maximum productivity was achieved in the treatment of extensive burns, deep trophic ulcers and open fractures complicated by suppuration of soft tissues. After several days of treatment, the spread of infection stopped and healing began.

It turns out that the percentage of Dioxidin is of great importance. Thus, for osteomyelitis, a 0.1% solution turned out to be the most effective, and for festering wounds - 1%. In the first stage of an infectious wound process, 5% Dioxidine ointment helped well.

For patients with severe bacterial lesions of the respiratory and urinary tract, the solution was administered intravenously 2 times a day. A good therapeutic effect was achieved in 88% of cases. The result was even better in patients with peritonitis. Intracavitary infusions of a 0.5% solution gave a 100% result.

Doctors at the All-Russian Center for Surgery B.V. Petrovsky prescribed Dioxidin in ampoules to prevent complications after operations on the abdominal organs. This made it possible to reduce the number of postoperative purulent inflammations. Experts noted excellent tolerability. Side effects were recorded only with intravenous administration; no side effects were noted with intracavitary or external use.

At the N. N. Burdenko Institute of Neurosurgery, the antiseptic became a real discovery. Endolumbar administration did not cause convulsions, which is very valuable for purulent pathologies of brain tissue.

All this increased the popularity of the drug, which became almost the main assistant in the fight against severe infections.

A fly in the ointment

And everything would be fine if not for one “BUT”. In fact, Hydroxymethylquinoxyline dioxide is a poison that requires careful attention. Designed for hospitals. Home use is possible only with strict adherence to the instructions for use of Dioxidin and only as prescribed by a doctor.

Perhaps many will have a question: if Dioxidin is so dangerous, why do pediatricians prescribe it to children? Unfortunately, some doctors, especially the old-school ones, like to prescribe Dioxidin drops for the nose or ear. At the same time, parents are given only a prescription without any accompanying explanations, which is unacceptable. You will learn very soon how to drip Dioxidin into a child’s nose and whether it is worth doing it. In the meantime...

Indications for use of Dioxidin

The antimicrobial agent effectively fights the bacteria Proteus vulgaris, salmonella, Friedlander's bacillus, staphylococci, Klebsiella, Shigella, pathogens of dysentery and gangrene. Prescribed for purulent processes of any localization. Indispensable in the treatment of pleurisy, cystitis, lung abscesses, phlegmon, burns.

Release form: solution (0.5% and 1%) and ointment (5%). For pneumonia, peritonitis, soft tissue abscesses, cystitis, mastitis and other infectious diseases of the chest, abdominal cavity, bile and urinary tract, Dioxidin solution is injected directly into the affected cavity.

Intravenous drip medication is prescribed for meningitis, sepsis, rapidly spreading purulent infection and for the prevention of postoperative complications.

Dioxidin ointment is used externally for burns, deep wounds, trophic ulcers, osteomyelitis and phlegmon.

Contraindications and side effects

The drug is not used to treat pregnant, lactating women and children. Individual intolerance to Hydroxymethylquinoxyline dioxide and adrenal insufficiency are also contraindications.

Most common side effects:

  • temperature increase;
  • chills;
  • cramps of the calf muscles;
  • headache;
  • insomnia;
  • stomach ache;
  • diarrhea;
  • vomit;
  • redness and itching of the skin.

If any unpleasant symptoms appear, stop taking it.

You need to know this!

Dioxidin is prescribed to children in exceptional cases. Before use, you should check the functioning of the urinary system and do a drug tolerance test.

The main disadvantage of the drug is its negative effect on the functioning of the adrenal glands. After 60 years, kidney performance decreases; for older people, a prescription is issued after laboratory tests.

The drug is recommended for stationary use. In this case, for intravenous drip administration it is better to use a 0.1% solution, because 1% is characterized by unstable storage. Store the antiseptic in a warm room.

If you see that the solution has crystallized, do not be alarmed. This happens often. Heat it in a water bath and use as recommended by your doctor.

Please note that administration of Dioxidin without a dropper (just into a vein) is contraindicated. Intracavitary administration is carried out using a catheter or syringe.

Dioxidin - a cure for a runny nose?

Doctors often prescribe Dioxidin for a runny nose. Trophic ulcers, meningitis, sepsis... And then “bang” - a runny nose? Is it possible to use Dioxidin for a runny nose? After all, there is nothing like that in the testimony.

First of all, you need to understand that the drug is not used for mild nasal congestion. There are other medications for this. The use of Dioxidin in the nose is justified if:

  • a runny nose has been bothering you for several months;
  • you have tried everything possible, including antibiotic therapy;
  • The discharge from the nasal passages acquired an unpleasant odor and a greenish color.

In these cases, the antiseptic helps well. It quickly suppresses pathogenic microflora and alleviates the general condition after just a few instillations.

Dioxidin is used not only in the treatment of severe burns and extensive phlegmon, but also sinusitis, otitis, and periodontal disease.

Now about the children. After reading the instructions for use, many parents will think about whether to drip Dioxidin into the child’s nose or not. And they will do the right thing by thinking about it. The use of this drug in pediatric practice is disputed. There are several reasons for this:

  • insufficient knowledge of the mechanism of action;
  • high probability of overdose;
  • a large selection of other, “softer” bactericidal agents.

However, sometimes Dioxidin is extremely necessary for children. We are talking about diseases when traditional treatment of chronic purulent processes does not bring results.

What are compound drops?

Doctors often prescribe complex drops with Dioxidin. This step has both pros and cons. First, let's define the terminology. Complex drops are a drug made according to an individual prescription. It is a mixture of several medicinal substances, “adapted” for a specific patient.

There can be many recipes. But the main “ingredients” remain unchanged: vasoconstrictors, antihistamines, hormonal and antibacterial agents. Dioxidin is most often used as an antibacterial.

In addition to Hydroxymethylquinoxyline dioxide, prescription Dioxidin contains Hydrocortisone and Adrenaline. The first prevents the development of allergies, the second constricts blood vessels. This is one of the most popular options. Others are also possible: Dioxidin in combinations with Galazolin, Dexamethasone, Mezaton, Cefazolin, Nazivin, Lincomycin... The exact composition is determined by the doctor after testing.

Pros: the ability to implement an individual approach in the treatment of a protracted inflammatory process, high efficiency, affordable cost.

Disadvantages: labor-intensive manufacturing, lack of information about the compatibility of medications, the ability of some drugs to affect the functioning of internal organs, additional side effects.

How to drip Dioxidin?

If you have been prescribed Dioxidin in ampoules into the nose or ear, then soak a cotton swab in 3% hydrogen peroxide (for the ears) or in saline solution (for the nose) and clean the passages. Carefully open the ampoule, take a pipette and drop 3 drops into each nasal (auditory) passage.

If unpleasant symptoms appear (dizziness, abdominal pain, calf muscle cramps), stop taking the drug.

Memo for parents!

Never drip Dioxidin into a child’s nose just because it has helped the son or daughter of one of the mothers you sometimes meet on the playground. Drops are used only as prescribed by a doctor whom you trust 100%.

Do you doubt the advisability of the appointment? Consult another pediatrician. It would be a good idea to do a bacterial culture of the discharge to identify the causative agent of the disease and its sensitivity to antibiotics. It may be possible to find a less toxic remedy for the treatment of a runny nose.

The sensitivity test was passed, but the prescribed antibiotic does not work? This is a completely justified reason to prescribe Dioxidin to your baby.

Many parents are stopped by the fact that in the annotation the medicine is positioned exclusively as a “medicine for adults.” This is true. But every rule has exceptions.

Don't compromise your child's health. If the drug is prescribed to you by a specialist whose competence has been tested by you many times, then trust him and ask in as much detail as possible about the specifics of using Dioxidin in childhood.

Dioxidin in the nose for children: instructions for use

The use of the drug for children has some peculiarities. So, only a 0.5% solution is used for instillation. You cannot put more than 2 drops into one nasal passage at a time. As a rule, the drug is dripped 3 times a day. Course duration is 3-5 days. In very severe cases - 7 days, but this is the limit.

Before starting therapy, it is necessary to conduct a test. Apply 1-2 drops and observe the child for 3-6 hours. Is your baby acting as usual? Treatment can begin!

Most often, side effects in children manifest themselves in the form of chills, sleep disturbances, rashes, and fever.

Some mothers do not instill drops, but treat the nasal sinuses with a cotton swab dipped in Dioxidin. The argument is less dangerous. Just the opposite. You can't do that. Such actions can lead to damage to the villi and mucous membrane.

The medicine is also not suitable for rinsing the nose. There is a high probability of the solution entering the Eustachian tube or being swallowed.

Is Dioxidin used for inhalation with a nebulizer?

Today, a nebulizer is popular in the treatment of coughs and runny noses. However, not all owners of a useful device know which solutions are suitable for inhalation and which are not. What doctors say about the use of Dioxidin in nebulizers and inhalers.

The solution can be used at home, but under strict control of the dosage of Dioxidin. Inhalations are prescribed for lung abscesses, pleural empyema, severe inflammation of the bronchi. Dioxidin is rarely prescribed for sinusitis, frontal sinusitis, sinusitis - in case of protracted course of the disease and the appearance of resistance (immunity) to other (weaker) drugs.

The concentrated solution is not poured into the nebulizer; it is diluted with saline solution. How to dilute Dioxidin correctly?

  • ampoules with a 1% solution are diluted in a ratio of 1:4;
  • ampoules with a 0.5% solution are diluted in a ratio of 1:2.

One inhalation will require 3 ml. What is left can be stored in the refrigerator for no more than 12 hours. The only point is that before inhalation, Dioxidin should be removed from the refrigeration chamber so that it warms up naturally. The solution must not be heated!

Dioxidine analogues

What analogues of Dioxidin can be found in pharmacies?

  • Dioxysept. Identical to Dioxidin in all respects: action, method of application, indications, side effects;
  • Dioxicol. Available in the form of an ointment. In addition to Dioxidin, it contains Trimecain, Methyluracil, and Polyethylene oxide. It is well tolerated and causes virtually no side effects;
  • Quinoxidine. Essentially, this drug is a tablet form of Dioxidin. Prescribed for multidrug-resistant urinary tract infections. Characterized by a high frequency of side effects from the digestive system;
  • Urotravenol. Consists of Dioxidine, Glycine and water. Supplied in sterile 10 liter containers. Used in hospitals for intracavitary administration.

Conclusion: Dioxidin is a powerful antiseptic that is prescribed in special cases. In large doses it is toxic, but if you follow medical recommendations, it helps where even the most modern antibiotics are powerless.

The article above and comments written by readers are for informational purposes only and do not encourage self-medication. Consult a specialist regarding your own symptoms and illnesses. When taking any medicine, you should always use the instructions that come with the medicine and your doctor's advice as a guide.

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Dioxidin: instructions for use

The drug Dioxidin is an antibacterial agent belonging to the quinoxaline group. Used in many areas of medicine.

Release form and composition of the drug

The drug Dioxidin is available in the form of a solution intended for intracavitary and external use. The solution has a concentration of 1% and is available in 10 ml transparent glass ampoules, in cardboard packs with detailed instructions. The contents of the ampoule are sterile; the medicine may have a yellowish or greenish tint.

The main active ingredient of the drug is hydroxymethylquinoxaline dioxide. One ampoule of the drug contains 100 mg of active substance. Water for injection acts as an auxiliary component.

Pharmacological properties of the drug

The drug Dioxidin is a broad-spectrum antibacterial agent, a derivative of quinoxaline. The active substance of the solution has pronounced chemotherapeutic activity against infectious processes caused by Pseudomonas aeruginosa, Proteus vulgaris, dysentery bacillus, salmonella, staphylococcus, streptococcus, gas gangrene pathogens, and Klebsiella. The drug is active even against those bacteria that are resistant to antibiotics and chemotherapy drugs.

With prolonged use of the solution, bacteria can develop immunity and become resistant. When administering the drug intravenously, the dose prescribed by the doctor should be strictly followed. When used externally as a means for treating wounds and purulent foci, it promotes rapid cleansing of the pathological surface from crusts and purulent contents, stimulates the processes of regeneration and epithelization of damaged tissues.

Indications for use

Dioxidin solution is prescribed to patients for the treatment and prevention of the following pathological processes:

  • Inflammatory infectious processes caused by pathological microflora - the drug is prescribed when antibiotics and other chemotherapeutic agents are ineffective;
  • Wound surfaces of varying severity and depth;
  • Trophic ulcers that do not heal for a long period of time;
  • Burns of varying degrees with the addition of a secondary bacterial infection;
  • Treatment of soft tissue phlegmon;
  • Suppurating wound surfaces caused by polio;

Intracavitary administration of the drug Dioxidin is prescribed for the following conditions:

  • Purulent inflammatory processes of the abdominal and thoracic cavity - peritonitis, lung abscess, cystitis, mastitis, phlegmon, postoperative wounds;
  • Complicated otitis;
  • Complicated sinusitis, sinusitis, rhinitis and other pathologies of the nasal cavity.

Contraindications for use

Dioxidin solution can only be used as prescribed by a specialist. Before starting therapy, it is recommended to carefully read the accompanying instructions, since the drug has the following contraindications:

  • Individual intolerance to the drug;
  • Pregnancy and breastfeeding period;
  • Adrenal cortex insufficiency;
  • Severe renal dysfunction, acute renal failure;
  • Children's age up to 12 years.

Method of administration and dosage of the drug

The drug Dioxidin is usually prescribed to patients in hospital settings. The drug is used in many areas of medicine - externally and internally.

If intravenous administration is necessary, the contents of the ampoule with Dioxidin are diluted to the required concentration with sterile physiological sodium hydrochloride solution. The dose and duration of drug therapy is determined by the doctor depending on the diagnosis and severity of clinical symptoms.

Treatment of wound surfaces

If it is necessary to treat open festering or poorly healing wound surfaces, lotions with dioxidine are used. To do this, a sterile gauze pad is moistened with a solution of the drug and applied to the wound. I tightly pack deep wounds with gauze turundas moistened with Dioxidine solution. If there is drainage, up to 100 ml of solution is injected into the wound cavity several times a day as an antiseptic.

To treat wounds caused by osteomyelitis, the wound surfaces are first washed with a 0.5% solution of Dioxidin, and then a gauze pad moistened with a 1% solution of the drug is applied.

The solution can be used to prevent the development of postoperative complications. To do this, the wound surface is treated daily with Dioxidin. In the absence of individual intolerance, this drug can be used for up to 1-2 months with normal tolerance.

Dioxidine in the nose

Dioxidin solution is used in the presence of complicated inflammatory processes in the nasal cavity, in particular for the treatment of sinusitis, sinusitis, frontal sinusitis and other pathologies. The nasal cavity is washed with Dioxidin solution 2-3 times a day, using a syringe for convenience. The drug has an excellent therapeutic effect in complicated sinusitis, when other drugs, including antibiotics, are ineffective. The punctured maxillary sinuses are washed with a solution of the drug 2-3 times a day, after which, if necessary, gauze turundas soaked in the solution are inserted into the nasal cavity.

Dioxidine in the ear

Dioxidin solution is prescribed to patients as an independent medicine or as part of complex therapy for purulent otitis and the spread of the pathological process to the Eustachian tube. In a hospital setting, the patient’s ear cavity is washed with a solution of the drug, after which a cotton or gauze turunda is inserted into the ear for a minute.

Intracavitary administration of the drug

A solution of the drug is injected into the purulent cavity through a catheter or drainage tube. The number of ml varies depending on the volume of the pathological cavity. As a rule, it is enough to inject the drug into the cavity once a day, using a 1% solution of Dioxidin.

The duration of drug therapy is determined by the doctor individually for each individual patient. If well tolerated and without side effects, Dioxidin can be used for up to 2 months, after which a break is taken and, if necessary, the course of therapy is repeated.

Use of the drug during pregnancy and breastfeeding

The use of Dioxidin solution while expecting a child is strictly contraindicated for women. Special studies were carried out, during which it was found that the active substance of the drug is capable of having a mutagenic and teratogenic effect on the development of the fetus in the womb; in addition, the solution is toxic to the embryo and can cause congenital deformities and anomalies.

The use of the drug during breastfeeding is contraindicated, since the active substance can penetrate into breast milk, and then into the baby’s body with food. If Dioxidin therapy is necessary during breastfeeding, it is recommended to interrupt lactation.

Side effects

During drug therapy, patients may experience the following side effects:

  • Chills, headaches, general weakness, convulsions - when the solution is injected into a vein or inside a cavity;
  • When used externally - allergic reactions in the form of burning, skin tightness, dryness, rash, swelling.

In severe cases, the patient may develop angioedema and anaphylaxis.

Drug overdose

With prolonged use of the solution intravenously or inside the cavity, overdose symptoms may develop, which are expressed in suppression of kidney function and disruption of the functioning of vital organs. If too large doses of the drug are accidentally administered orally, the patient should remain under the supervision of specialists with monitoring of important vital parameters. If necessary, symptomatic treatment is carried out.

If the allergic reactions described above develop, the patient is prescribed antihistamines, the dose of Dioxidine is reduced or therapy is stopped completely.

special instructions

The drug Dioxidin is intended only for the treatment of adult patients. Before you start using the solution, you must do a tolerance test. If there are no side effects, the drug can be used for treatment within 4 hours.

The drug is prescribed only in extreme cases in the absence of a therapeutic effect from the use of antibiotics and antibacterial drugs from the group of fluoroquinols, cephalosporins, and carbapenems.

For patients with chronic renal failure, the dose of the drug is selected strictly individually!

When storing ampoules with solution in the refrigerator, precipitation or crystals may form. In this case, before starting therapy, the ampoule is heated in hot water or over boiling water steam until the crystal is completely dissolved. Next, the solution should be cooled to the patient’s body temperature; if during this period crystals do not form again and the solution remains clear, then it can be used for treatment. If crystals form again, the medicine should be thrown away, even if it has not yet expired.

Analogues of the drug Dioxidin

The following drugs are similar in their therapeutic effect to Dioxidin solution:

Before replacing a prescribed drug with its analogue, the patient should definitely consult a doctor, since not all of these drugs have the same therapeutic activity as Dioxidin solution.

Conditions of release and storage

The drug is sold only with a prescription from a doctor. It is recommended to store the solution in a cool, dark place out of reach of children. The expiration date is indicated on the packaging; when it expires, the medicine should be thrown away.

If the integrity of the ampoule is damaged or the solution becomes cloudy, the medicine cannot be used!

The average cost of the drug Dioxidin in ampoules in Moscow pharmacies is 360 rubles per pack of 10 pieces.

Source: http://bezboleznej.ru/dioksidin

Dioxidin - instructions for use in nasal ampoules for adults and children

Dioxidin is a synthetic antibiotic that is a derivative of quinoxaline. It has a number of specific features that determine the scope of its application in medical practice. It exhibits the greatest bactericidal activity under anaerobic conditions, destroying all the most common types of pathogens of purulent infection.

It is usually used in a hospital setting for the treatment of septic conditions, as it is a reserve antibacterial drug. Its effectiveness is combined with high toxicity, so the drug is prescribed only if treatment with other, less toxic antibiotics fails.

Dioxidin: instructions for use in nasal ampoules

The drug has been used in medicine for several decades and has proven itself as a broad-spectrum antimicrobial agent. The most sensitive to it are Proteus, many varieties of Klebsiella, Pseudomonas and Escherichia coli, pseudomonas, staphylo- and streptococci, salmonella (especially insensitive to other groups of antibiotics). Resistance to it in bacteria develops quite slowly.

The active substance - hydroxymethylquinoxylin dioxide - destroys pathogenic microorganisms by introducing into them and blocking DNA biosynthesis. As a result, the cell is not able to divide, and irreversible destructive processes occur in the structure of its cytoplasm and nucleotide. This is made possible by two special NO groups that activate free radicals under anaerobic conditions. However, this same property also has negative consequences for the macroorganism, which causes the high toxicity of the drug.

Dioxidine release form

The drug is produced by several Russian and foreign pharmaceutical enterprises from yellowish powdery raw materials. The following dosage forms can be purchased in pharmacies:

  • An ointment intended for topical use, produced by Penza JSC Biosintez. The concentration of hydroxymethylquinoxyline dioxide is 5%.
  • Solution (used for infusion and topically) 5 mg/ml – product of Shchelkovsky OJSC “Valenta Pharmaceuticals”. Sold in pharmacy chains in five- or ten-milliliter glass ampoules, 3, 5 or 10 pieces in each package.
  • Dioxidine solution 10 mg/ml is 1 percent of the active ingredient in the drug. Produced by the companies “Valenta Pharmaceuticals”, OJSC “Novosibkhimpharm”, LLC “FERMENT” in ampoules of 5 or 10 ml, used for intracavitary administration and topically.

The solution contains, in addition to hydroxymethylquinoxylin dioxide, which makes up 0.5 or 1 percent of the total volume, water for injection. The latter is sterile distilled water, which serves as a universal solvent for many medicines.

Indications

As mentioned above, Dioxidin is especially effective against anaerobic strains of pathogenic bacteria. Clinical studies that lasted a decade and a half have revealed the high effectiveness of the drug in antibiotic therapy for the following pathologies:

  • Cellulitis, pyothorax, peritonitis, pleurisy, abscesses of the lungs and mediastinum, in which the solution can be administered either intravenously or directly into the body cavity.
  • Trophic and purulent skin ulcers, wound infections, burns. In the latter case, the drug is especially effective in helping to avoid sepsis and speeds up healing.
  • Osteomyelitis.
  • Inflammation of the urinary system (cystitis, for example).
  • Inflammatory processes in the mammary glands.

All of these diseases are treated in a hospital, but Dioxidin can also be used on an outpatient basis, but only on the recommendation of the attending physician. Typically, the medicine in this case is used for antibiotic therapy of chronic or complicated bacterial rhinitis, which does not respond to treatment with other antibiotics for a long time, and sinusitis. In this case, bacterial culture is done, which identifies the specific cause (type of pathogen).

Dioxidin in the nose for an adult: regimen and dosage

You can do rinsing yourself at home. For sinusitis or a runny nose, this method helps to quickly get rid of painful symptoms. It is recommended to use a solution for intracavitary administration (i.e. 0.5%) without dilution. The 1% drug is diluted with water in a one to one ratio.

Before rinsing, you should remove existing nasal congestion. If it is impossible to do this mechanically, you need to use special vasoconstrictor drops (for example, naphthyzine). It is also advisable to rinse the nasal passages with a saline solution, which thins the accumulated mucus.

Dioxidin can also be dripped into the nose of an adult. This method is more convenient and effective than washing. The solution prescribed is the same as in the previous case (0.5%), it does not need to be diluted. The treatment regimen is as follows: three times a day, after preliminary cleaning of the nasal passages, 2 drops of medicine are instilled into each of them. Since there are no special dosage forms for intranasal use, this is done with a pipette. Usually the duration of the course does not exceed 5 days, but advanced cases may require weekly therapy.

In addition to the finished medication in ampoules, the otolaryngologist can prescribe a combined composition based on it, which is prepared in a pharmacy according to an individual prescription. The most common option is where Dioxidin is combined with hydrocortisone. The main component fights the pathogen, and the auxiliary components provide the prevention of allergies and alleviation of symptoms due to the vasoconstrictor effect. Such mixtures can successfully treat bacterial rhinitis, but not all pharmacies manufacture such compositions.

Contraindications of Dioxidine and its side effects

The pharmacodynamic features make the drug quite toxic and require some caution when using it (especially in patients with chronic kidney failure). The instructions for use strictly prohibit treatment with all forms of the drug for the following persons:

  • under the age of 18;
  • pregnant and lactating women;
  • having hypersensitivity to quinoxalines;
  • with a history of adrenal insufficiency.

The development of side effects is quite high, especially with intravenous and intracavitary administration. In these cases, there may be an increase in temperature accompanied by chills, headache, dyspepsia (nausea, vomiting, digestive disorders), photosensitivity and allergic reactions. If the drug is used topically, itching and periwound dermatitis are likely to occur.

Dioxidin during pregnancy

The effect of hydroxymethylquinoxylin dioxide on the body has been studied over many years of research. As a result, its mutagenic and teratogenic effects were reliably established. Women at any stage of pregnancy should not be prescribed this drug, and not only intravenously or into the body cavity. Even local use in the form of ointments, compresses or nasal drops ensures the penetration of the active substance into the bloodstream through the mucous membranes and skin. For the same reason, treatment with Dioxidin during lactation is excluded (a temporary transition to pumping and artificial feeding is usually recommended).

How to dilute a solution for compresses and nasal drops for adults

For intranasal use in adults, a 0.5% ready-made drug in ampoules without dilution is usually used. If a one percent solution is used, the medicine is diluted with water for injection (1:1). Compresses are prescribed, as a rule, in the postoperative period to prevent infection of sutures and treat purulent wounds. This is usually done in a hospital setting by qualified health workers. However, outpatient treatment with compresses with dioxidine is also possible.

Trophic and purulent ulcers and wounds are treated by applying napkins soaked in a 0.5-1 percent solution, and deep injuries are loosely tamponed. For osteomyelitis of the extremities (with the formation of purulent areas), baths with a medicine of a similar concentration are indicated. The listed cases do not require dilution, but for postoperative sutures the drug must be diluted with isotonic saline solution or water for injection (to an active substance content of 0.1-0.2 percent) in a sterile container.

How to store an open ampoule of Dioxidine

Without compromising the integrity of the packaging, this medicine can be stored for 2 years, but it is better to throw away the opened ampoule with any remaining medicine. However, repeated use within 24 hours is allowed. To do this, you need to tightly close the hole with a piece of sterile cotton wool and place the ampoule in the refrigerator until the next use (before using it, warm it to room temperature in a water bath).

Instead of storing an open ampoule, it is better to dilute dioxidin and keep it in the refrigerator for a day in a regular disposable syringe. This method is preferable, as it facilitates the use of the drug. Firstly, the measuring scale allows you to accurately measure the volume of the medicine itself and the dilution liquid. Secondly, drawing them from ampoules and vials is much more comfortable. Thirdly, sterility is maintained both during dilution and during storage, and dripping from it is no more difficult than from a pipette.

Dioxidine solution in the nose of children: how to dilute?

As mentioned in the corresponding section, this medication is strictly contraindicated in patients under 18 years of age. However, in special cases its use is advisable. A pediatrician may prescribe medication to a child if a chronic form of rhinitis that is not amenable to antibiotic therapy with other medications is diagnosed. Beforehand, a bacterial culture must be done and the causative agent is determined, and an allergy test is also carried out.

Since children are more sensitive to drug therapy and prone to allergic reactions (and children's dioxidine is not available), the medicine must be diluted. To do this, the finished one percent preparation is usually diluted with saline solution in a sterile container in a ratio of 1:4. You need to drip three times a day, no more than two drops in each nasal passage. Course duration is from 3 to 5 days.

Sometimes the medicine is used in nebulizers. These devices have long proven their effectiveness, and in combination with a solution of hydroxymethylquinoxylin dioxide, such therapy allows you to quickly get rid of painful symptoms. The dilution should also be 1 to 4 (1% solution) or 1:2 if 0.5% dioxidine is used. Use only after consultation with a pediatrician and with his permission.

A warning to parents

The medicine is toxic, and the dilution scheme must be determined and explained by the doctor (the younger the patient, the weaker the concentration of the active substance should be). Unfortunately, many parents trust the advice of non-medical sites, forums and friends more, and non-specialists often confuse the names of drugs. For example, dioxidin and dimexide, and the difference between them is very significant.

Unlike the subject of this article, Dimexide is intended exclusively for external use for suppuration, burns and skin grafts, injuries and diseases of the musculoskeletal system (arthritis, bruises, sprains). In addition, children under 12 years of age should not use it. Without dilution, the product can cause a chemical burn, which completely excludes the treatment of a runny nose in a child.

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