Dioxidin 1 percent instructions

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Dioxidin: instructions for use

Dioxidine is an antibacterial drug from the group of quinoxaldine derivatives.

It has bactericidal and antibacterial effects on various pathogens: Pseudomonas aeruginosa, staphylococci, pathogenic anaerobes and other strains of bacteria resistant to other antibiotics.

Table of contents:

It is usually used in a hospital setting for the treatment of septic conditions, as it is a reserve antibacterial drug. Its effectiveness is combined with high toxicity, so the drug is prescribed only if treatment with other, less toxic antibiotics fails.

On this page you will find all the information about Dioxidin: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Dioxidin in ampoules. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibacterial drug, quinoxaline derivative.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

How much does Dioxidin cost? The average price in pharmacies is 300 rubles.

Release form and composition

Dioxidin has several forms of release:

  • ointment 5%;
  • Dioxidine solution (0.5%) for intravenous injection;
  • Dioxidine in ampoules for inhalation (5 mg) and intracavitary use (1%).

Dioxidin 1% solution is available in 10 ml glass ampoules. 1 ml of a clear, colorless solution contains 10 mg of the active ingredient dissolved in water for injection.

Dioxidin 5 mg for inhalation is produced in ampoules of 10 and 20 ml. In each milliliter of the drug in water for injection, 5 mg of hydroxymethylquinoxaline dioxide is dissolved. Ampoules containing solution for injection and inhalation are placed in 10 pieces in cardboard packages.

Pharmacological effect

Dioxidin is a synthetic bactericidal agent that is used in the treatment of purulent and infectious pathologies. Usually the drug is used externally, however, if necessary, intracavitary lavage and intravenous administration are allowed.

Dioxidin has a detrimental effect on pathogenic cells by inhibiting the formation of DNA, but does not affect the production of RNA and protein. Also, the main active ingredient destroys the microbiological structure (shell and nucleotides, which play an important role in the formation of intracellular energy).

The drug is widely used in medicine due to its effective suppression of pathogenic flora in anoxic conditions.

Indications for use

According to the instructions, Dioxidin is indicated for use in bacterial infections that are sensitive to the active component of the drug.

External use of Dioxidin is advisable in the following cases:

  1. Infected burns;
  2. Soft tissue phlegmon;
  3. Deep or superficial wounds on the body;
  4. Trophic ulcers and long-term non-healing wounds;
  5. Purulent wounds with osteomyelitis.

Intracavitary administration of Dioxidin is indicated in the following cases:

  1. Peritonitis;
  2. Abscesses;
  3. Purulent pleurisy;
  4. Purulent processes in the abdominal or thoracic cavity;
  5. Wounds of the biliary and urinary tract;
  6. Pleural empyema;
  7. Wounds and phlegmon with the presence of deep purulent cavities (pelvic cellulitis, soft tissue abscesses, purulent mastitis, postoperative wounds of the biliary and urinary tract).

Contraindications

Dioxidin is contraindicated for:

  • individual intolerance to the drug;
  • dysfunction of the adrenal glands;
  • pregnancy and lactation;
  • under 12 years of age.

Despite the obvious positive effect of the drug in the treatment of purulent-microbial pathologies, the high toxicity of dioxidin has determined it to be a reserve drug, especially for intravenous infusions.

Use during pregnancy and lactation

The effect of hydroxymethylquinoxylin dioxide on the body has been studied over many years of research. As a result, its mutagenic and teratogenic effects were reliably established.

Women at any stage of pregnancy should not be prescribed this drug, and not only intravenously or into the body cavity. Even local use in the form of ointments, compresses or nasal drops ensures the penetration of the active substance into the bloodstream through the mucous membranes and skin. For the same reason, treatment with Dioxidin during lactation is excluded (a temporary transition to pumping and artificial feeding is usually recommended).

Instructions for use

The instructions for use indicate that Dioxidin is most often used in hospital settings. A 1% solution of the drug is usually not used for intravenous injection (due to the instability of the drug when stored at low temperatures). Use 0.1-1% solutions, for which the drug is diluted with water for injection or sodium chloride solution.

External use of Dioxidin:

  1. To prevent infections after operations, Dioxidin is used in the form of a 0.1-0.5% solution.
  2. When treating superficial infected purulent wounds, wipes soaked in a 0.5-1% solution of Dioxidin are applied to the wound. When treating deep wounds, they are loosely tamponed with tampons pre-moistened in a 1% solution. If there is a drainage tube, a 0.5% solution, from 20 to 100 ml, is injected into the cavity.
  3. For the treatment of deep purulent wounds with osteomyelitis - in the form of baths with a 0.5-1% solution. Less commonly, special treatment of the wound is carried out by injecting the drug for a minute, then apply a bandage with a 1% solution of Dioxidine. If the drug is well tolerated, treatment can be carried out daily for 1.5-2 months.

For intracavitary administration, a catheter, syringe or drainage tube is used. A 1% solution of the drug is injected into the purulent cavity; the dose depends on the size of the cavity, usually ml per day. Usually the drug is administered once a day. The maximum daily dose is 70 ml. Treatment can be continued for three weeks or more if indicated and well tolerated.

Instructions for use of Dioxidin in the nose

Dioxidin solution is used in the presence of complicated inflammatory processes in the nasal cavity, in particular for the treatment of sinusitis, sinusitis, frontal sinusitis and other pathologies. The nasal cavity is washed with Dioxidin solution 2-3 times a day, using a syringe for convenience.

The drug has an excellent therapeutic effect in complicated sinusitis, when other drugs, including antibiotics, are ineffective. The punctured maxillary sinuses are washed with a solution of the drug 2-3 times a day, after which, if necessary, gauze turundas soaked in the solution are inserted into the nasal cavity.

Dioxin in the ear

To treat otitis media, it is usually customary to use antibiotics and vasoconstrictor drugs. However, in cases where they are not effective, Dioxidin becomes the drug of choice, a feature of which is its effectiveness against anaerobic bacteria.

Before instilling the medicine, it is recommended to clean the ear canal from wax using a cotton swab soaked in a 3% hydrogen peroxide solution or special cotton swabs (for convenience, the auricle is slightly pulled back). If the ear is very dirty, leave the tampon with peroxide in it for about 5 minutes.

  1. In case of purulent otitis media, which is often accompanied by perforation of the eardrum and discharge of pus, all purulent contents are first removed from the ear canal before instillation.
  2. For otitis, Dioxidin should be injected simultaneously into the nose and into the ear canal. The solution effectively sanitizes the nasal cavity and stops the inflammatory process in it, and since the nose is connected to the ear by the Eustachian tube, relieving the inflammatory process in the nose has a beneficial effect on the situation as a whole.

The dose and frequency of instillations are selected individually in each specific case and exclusively by the attending physician.

Dioxidin ointment

Used to treat purulent wounds, trophic ulcers, phlegmon, wounds with osteomyelitis, pustular skin rashes. Apply a thin layer to the surface of the skin, and insert tampons with ointment into the purulent wounds. The daily dose for adults should not be more than 2.5 g. The duration of use of the product is 3 weeks.

Inhalation with a nebulizer

Today, a nebulizer is popular in the treatment of coughs and runny noses. However, not all owners of a useful device know which solutions are suitable for inhalation and which are not. What doctors say about the use of Dioxidin in nebulizers and inhalers.

The solution can be used at home, but under strict control of the dosage of Dioxidin. Inhalations are prescribed for lung abscesses, pleural empyema, severe inflammation of the bronchi. Dioxidin is rarely prescribed for sinusitis, frontal sinusitis, sinusitis - in case of protracted course of the disease and the appearance of resistance (immunity) to other (weaker) drugs.

The concentrated solution is not poured into the nebulizer; it is diluted with saline solution. How to dilute Dioxidin correctly?

  • ampoules with a 1% solution are diluted in a ratio of 1:4;
  • ampoules with a 0.5% solution are diluted in a ratio of 1:2.

One inhalation will require 3 ml. What is left can be stored in the refrigerator for no more than 12 hours. The only point is that before inhalation, Dioxidin should be removed from the refrigeration chamber so that it warms up naturally. The solution must not be heated!

Side effects

Dioxidin when administered intracavitarily can cause:

  • dyspeptic disorders;
  • convulsive muscle contractions;
  • allergic reactions;
  • headache;
  • chills;
  • rising temperatures;
  • photosensitizing effect (appearance of pigmented spots on the body when exposed to sunlight);
  • periwound dermatitis (for external use).

When used externally, Dioxidin can cause periwound dermatitis.

Overdose

Symptoms of overdose include both excessive symptoms from the list of side effects and acute insufficiency of adrenal cortex function:

  1. To cope with the difficulty of synthesizing corticosteroids (stress hormones), therapy must be stopped.
  2. For other manifestations of overdose, therapeutic methods are selected - symptomatic treatment.

Hormone replacement therapy is allowed - in the form of doses of glucocorticosteroids determined by the doctor (normally - up to 1 mg per kilogram of the patient’s weight).

special instructions

  1. The drug is prescribed only if other antibacterial drugs are ineffective, including fluoroquinolones, cephalosporins of II-IV generations, carbapenems.
  2. Before starting to use Dioxidin, a drug tolerability study must be carried out. To do this, a small volume (10 ml) of a 1% solution is injected into the cavities and the patient’s condition is monitored for 3-6 hours. If no side effects (chills, fever, dizziness) occur during this time, the drug can be used for a course of treatment.
  3. If pigment spots occur, increase the duration of a single dose to 1.5-2 hours, reduce the dose, discontinue dioxidine or prescribe antihistamines.

Reviews

We have selected some people's reviews about the drug Dioxidin:

  1. Elena . I usually use dioxidine solution to treat a persistent runny nose in my child. I mix it in equal parts with aloe extract and drip twice a day. The product is cheap and very effective. Does not dry out the mucous membranes and does not cause discomfort.
  2. Anna . One day in early spring I began to feel stuffy in my ears. I tried traditional methods of treatment, but the disease only worsened. The otolaryngologist prescribed dioxidine drops. At the same time, the doctor assured that the drug has absolutely no side effects. Having instilled the maximum dose of the drug into the auricle, I felt a burning sensation. After that, I read the instructions and discovered a large number of side effects. For treatment, I reduced the dose and quickly cured the inflammation of the ear canal. I recommend this drug to everyone, but read the instructions carefully before using it.
  3. Tanya. Dioxidin is a very good medicine. I only use it for mixed drops, for the nose. For a runny nose that I can’t cure for more than a week or two, this is an indispensable remedy! The ENT doctor prescribed it to me and said that even sinusitis can be treated with mixed drops, and patients don’t have to pierce their sinuses. Here is the recipe: Dioxidin 1% - 5 ml, Mezaton - 2 ml, Dexamethasone - 2 ml = mix everything in 10 cubic meters. syringe, and drip 2 drops, 3 times a day. The nose breathes, and the runny nose goes away very quickly. The price is affordable, even very, and you can find this drug in all pharmacies.
  4. Sasha . For furunculosis, I was prescribed Dioxidin in ampoules, which I placed on gauze rolled up in several layers, which I dipped into a printed ampoule of solution to the place where the boil broke out. Surgeons said that this medicine is an antibiotic and sucks out pus well. In principle, he did his own work for his own money and the wounds were cleared of pus quickly, faster than before, when they simply changed the bandages or applied Ichthyol ointment.

Analogs

What analogues of Dioxidin can be found in pharmacies?

  1. Dioxysept. Identical to Dioxidin in all respects: action, method of application, indications, side effects.
  2. Dioxicol. Available in the form of an ointment. In addition to Dioxidin, it contains Trimecain, Methyluracil, and Polyethylene oxide. It is well tolerated and causes virtually no side effects.
  3. Urotravenol. Consists of Dioxidine, Glycine and water. Supplied in sterile 10 liter containers. Used in hospitals for intracavitary administration.
  4. Quinoxidine. Essentially, this drug is a tablet form of Dioxidin. Prescribed for multidrug-resistant urinary tract infections. It is characterized by a high frequency of side effects from the digestive system.

Before using analogues, consult your doctor.

Storage conditions and shelf life

On average, the drug has a long shelf life (3 years), less often – 24 months. Any form (ointment, ampoules) is available only with a prescription. Storage conditions:

  • in a safe place, out of reach of children;
  • at a temperature of degrees;
  • in a dry place protected from light.

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2 comments

Dioxidin is the best and most effective antimicrobial drug created in the history of medicine. Quickly inactivates almost all pathogenic microorganisms known to science, including some protozoa, and without side effects. If the recommended dosages are followed, local, intracavitary use does not cause any toxic effects.

Particularly effective for the treatment of bacterial infections of the respiratory tract in immunocompromised individuals by instillation into the nose, inhalation of a 1% solution using a pocket inhaler and rinsing the maxillary sinuses. The effectiveness has been proven many times personally for me and many others. Dioxidin is a Russian miracle that has almost no analogues abroad. Thanks to the developers and Soviet science.

I suffer from chronic sinusitis, often exacerbations especially against the background of severe colds. At the clinic, the ENT doctor advised, in addition to traditional antibiotic tablets, to use the antibacterial agent Dioxidin by instilling it directly into the nose.

First you need to clear your nose (if it is clogged) using some vasoconstrictor (Xylene, Rinostop, Nazivin, etc.), then take an ampoule of a 1% solution and drop 2 drops into each nostril 3 times a day.

You can use a syringe or pipette for this. Sometimes there may be temporary mild discomfort - a burning sensation in the nose or tingling, but this does not last long. I can say for sure – it helps 100%.

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Source: http://simptomy-lechenie.net/dioksidin/

Dioxidine

Description current as of 01/13/2015

  • Latin name: Dioxydin
  • ATX code: J01XX
  • Active ingredient: Hydroxymethylchinoxalindioxydum
  • Manufacturer: JSC “Biosintez”, Nizhpharm, Novosibkhimpharm, Moskhimfarmpreparaty im. ON THE. Semashko, Russian Federation PJSC “Farmak”, Ukraine

Compound

One milliliter of a 1% solution for external and intracavitary use includes 10 mg of hydroxymethylquinoxaline dioxide, as well as water for injection in a volume of up to 1 ml.

A milliliter of 0.5 percent solution for local, intravenous and intracavitary use contains 5 mg of hydroxymethylquinoxaline dioxide and water for injection as an excipient (in a volume of up to 1 ml).

A gram of Dioxidin ointment contains 50 mg, as well as excipient substances: polyethylene oxide 400, polyethylene oxide 1500, nipagin, propyl ester of paraoxybenzoic acid.

Release form

The drug has the following dosage forms:

  • Dioxidin solution 1% for intracavitary and local use;
  • Dioxidin solution 0.5% for local, intravenous and intracavitary use;
  • Dioxidin ointment 5%.

A one percent solution is available in 10 ml colorless glass ampoules, 10 ampoules in one package; a 0.5% solution is supplied to pharmacies in colorless glass ampoules of 10 and 20 ml; The ointment is packaged in tubes of 25, 30, 50, 60 and 100 grams.

pharmachologic effect

Dioxidin is a product from the group of synthetic antibacterial bactericidal drugs. The active substance of the drug belongs to the group of quinoxaline derivatives and is characterized by a wide range of pharmacological activity.

Pharmacodynamics and pharmacokinetics

The mechanism of action of Dioxidin is associated with the damaging effect of hydroxymethylquinoxaline dioxide on the cell walls of microorganisms, which ultimately suppresses their vital activity and leads to their death.

The drug is active against Proteus vulgaris, Friedlander's bacillus, Pseudomonas aeruginosa, pathogens of bacterial dysentery from the genus Shigella (Shigella dysenteria, Shigella flexneri, Shigella boydii, Shigella sonnei), salmonella, which is the most common causative agent of acute diarrhea (Salmonella spp.), Escherichia coli (Escherichia coli), staphylococci (Staphylococcus spp.), streptococci (Streptococcus spp.), which are the causative agents of food toxic infections of pathogenic anaerobic bacteria Clostridium perfringens.

Dioxidin is capable of affecting bacterial strains resistant to other antimicrobial agents (including antibiotics). In this case, the product does not cause local irritation.

The possibility of development of drug resistance of microflora to the drug cannot be excluded.

When administered into a vein, it has a small therapeutic breadth of action, which in turn presupposes strict adherence to the dosage regimen specified in the instructions.

Treatment of burned areas of the body with the drug, as well as purulent-necrotic wounds, allows you to accelerate the healing process of the wound surface, reparative (restorative) tissue regeneration, as well as their marginal epithelization, and has a beneficial effect on the course of the wound process.

Experimental studies have established that the drug is capable of having teratogenic, mutagenic and embryotoxic effects.

When used as a local remedy, it is partially absorbed from the wound or burned surface treated with it. It is eliminated from the body by the kidneys.

After injection into a vein, the therapeutic concentration of hydroxymethylquinoxaline dioxide in the blood remains for the next 4-6 hours. Plasma concentration after a single injection of the solution reaches a maximum after approximately 1-2 hours.
The active substance quickly and easily penetrates into all tissues and internal organs and is excreted by the kidneys. With repeated administrations it does not accumulate in the body.

Indications for use

Indications for IV administration of Dioxidin are:

  • septic conditions (including conditions developing against the background of burn disease);
  • purulent meningitis (purulent-inflammatory damage to the membranes of the brain);
  • purulent-inflammatory processes accompanied by symptoms of generalization.

Intracavitary administration of Dioxidin in ampoules is indicated for purulent-inflammatory processes occurring in the chest or abdominal cavity, including:

  • purulent pleurisy (pleural empyema);
  • peritonitis (an inflammatory process affecting the parietal and visceral layers of the peritoneum);
  • cystitis (inflammation of the bladder);
  • empyema of the gallbladder (acute purulent inflammation of the gallbladder).

Intracavitary injections can also be prescribed for prophylactic purposes to prevent the development of infectious complications after bladder catheterization.

Dioxidin is used as an external and local remedy:

  • for the treatment of burns, trophic ulcers and wounds (including deep and superficial, of various locations, infected and purulent, difficult and long-term healing);
  • for the treatment of wounds that are characterized by the presence of deep purulent cavities (for example, purulent pleurisy, soft tissue abscesses, phlegmon and pelvic abscesses, postoperative wounds on the organs of the urinary and biliary system, purulent mastitis, etc.);
  • for the treatment of infectious skin lesions (pyoderma) caused by the activity of streptococci or staphylococci.

Contraindications

The use of Dioxidin is contraindicated:

Side effects

Intracavitary administration and administration of Dioxidin into a vein may be accompanied by:

When Dioxidin is applied topically, periwound dermatitis and itching may occur in the area of ​​the body treated with the drug.

Instructions for use of Dioxidin (Method and dosage)

Instructions for use of Dioxidin in ampoules

Dioxidin is administered intravenously by drip. In severe purulent-septic conditions, the solution before administration is pre-diluted with an isotonic solution (5% dextrose solution or 9% NaCl solution) to obtain a concentration of 0.1-0.1%.

The maximum permissible single dose is 0.3 grams, daily dose is 0.6 grams.

In cases where the patient is indicated for external use of Dioxidin, the drug is used for packing deep wounds, as well as irrigating affected areas of the body.

After preliminary cleaning and treatment, deep wounds are recommended to be loosely tamponed with tampons soaked in a 1% solution.

If the patient has a drainage tube, he is advised to administer 20 to 100 ml of a 0.5% solution into the cavity.

Therapy of deep purulent wounds on the hands or feet with osteomyelitis involves the use of Dioxidin solutions (0.5 or 1%, as indicated by the attending physician) in the form of baths.

Special treatment of the wound surface within minutes is also allowed: the drug is injected into the wound for a specified time, after which a bandage with a 1% solution of the drug is applied to the affected area of ​​the body.

Treatment of superficial infected purulent wounds involves applying wipes soaked in a 0.5 or 1% solution to the wound surface.

It is recommended to repeat the procedure daily or every other day (the frequency of applications depends on the condition of the wound and the characteristics of the wound process). The highest daily dose is 2.5 grams. Treatment with Dioxidin is usually continued for up to 3 weeks.

For patients with osteomyelitis, as well as if the drug is well tolerated, in some cases treatment can be continued for 1.5-2 months.

If intracavitary administration of the drug is necessary, the patient should inject 10 to 50 ml of a 1% solution into the cavity daily through a catheter or drainage tube. The drug is administered using a syringe, usually once. In some cases, Dioxidin may be administered in 2 doses according to indications.

The course of treatment lasts from 3 weeks. If appropriate, it is repeated after 1-1.5 months.

The highest daily dose for intracavitary administration is 70 ml.

Instructions for use of Dioxidin in the ear

To treat otitis media, it is usually customary to use antibiotics and vasoconstrictor drugs. However, in cases where they are not effective, Dioxidin becomes the drug of choice, a feature of which is its effectiveness against anaerobic bacteria.

Before instilling the medicine, it is recommended to clean the ear canal from wax using a cotton swab soaked in a 3% hydrogen peroxide solution or special cotton swabs (for convenience, the auricle is slightly pulled back). If the ear is very dirty, leave the tampon with peroxide in it for about 5 minutes.

In case of purulent otitis media, which is often accompanied by perforation of the eardrum and discharge of pus, all purulent contents are first removed from the ear canal before instillation.

For otitis, Dioxidin should be injected simultaneously into the nose and into the ear canal. The solution effectively sanitizes the nasal cavity and stops the inflammatory process in it, and since the nose is connected to the ear by the Eustachian tube, relieving the inflammatory process in the nose has a beneficial effect on the situation as a whole.

The dose and frequency of instillations are selected individually in each specific case and exclusively by the attending physician.

According to the instructions for use, Dioxidin drops are prohibited from being prescribed to patients under 18 years of age. However, in some situations, when it is not possible to achieve an effect using other means, pediatricians prescribe the medicine even to small children.

Instructions for use of Dioxidin in the nose

Prescription of Dioxidna in ampoules into the nose is used when it is necessary to treat certain forms of rhinitis, as well as for sinusitis.

For the treatment of adult patients, the drug should be pre-diluted with NaCl solution, hydrocortisone or water for injection before instillation. Dosage in the nose for an adult - from 2 drops to ⅓ pipette. Dioxdin drops are dripped into the nose 3 to 5 times a day. More precisely, the dose and the required frequency of procedures are determined by the attending physician.

The maximum duration of treatment should not exceed 7 days. If after this period the patient does not show improvement, he requires careful examination and, based on his results, appropriate treatment.

There are no official instructions for the use of Dioxidin in the nose for children. However, if appropriate, doctors also use the drug to treat children. Before instilling Dioxidin into the nose, the solution should be diluted to a concentration of 0.1-0.2%. As in the situation with adults, the doctor selects the treatment regimen individually.

As a rule, Dioxidin is administered to a child's nose 1-2 drops 2 or 3 times a day for 3-5 (maximum 7) days.

Inhalations with Dioxidin for adults

Inhalation therapy is one of the main types of treatment for respiratory tract diseases.

To prepare a solution for inhalation, the medicine is diluted with physiological solution in a ratio of 1:4 for a drug with a concentration of 1% and in a ratio of 1:2 for a drug with a concentration of 0.5%.

For one procedure, 3 to 4 ml of the resulting solution is used. The frequency of procedures is 2 times a day.

Dioxidin ointment: instructions for use

The ointment is applied topically. It is recommended to apply a thin layer to the affected area of ​​the body once a day. The course of treatment is up to three weeks.

Overdose

In case of an overdose of Dioxidin, acute adrenal insufficiency may develop, which requires immediate discontinuation of the drug and the appointment of appropriate hormone replacement therapy.

Interaction

For patients with hypersensitivity to hydroxymethylquinoxaline dioxide, Dioxidin is prescribed in combination with antihistamines or calcium preparations.

Terms of sale

Storage conditions

Dioxidin is included in List B. It is recommended to store the medicine in a light-protected place, out of the reach of children. Optimum storage temperature°C.

Best before date

special instructions

Prescription of Dioxidin is resorted to only in cases where the use of other antimicrobial drugs (including carbapenems, fluoroquinolones, cephalosporins of the II-IV generations) did not produce the expected effect.

For patients with chronic renal failure, the dosage regimen should be revised towards a lower dose.

When administered intravenously, Dioxidin has a narrow therapeutic range, which requires constant monitoring of compliance with the recommended dosage regimen.

To prevent the development of side effects, treatment with Dioxidin is supplemented with the prescription of antihistamines and calcium supplements. If adverse reactions do occur, the dose is reduced and the patient is prescribed antihistamines.

In some cases, the occurrence of adverse reactions is a reason to discontinue the drug.

If pigment spots appear on the skin, the dose should be reduced, while increasing the duration of its administration (a single dose is administered over one and a half to two hours) and supplementing the therapy with antihistamines.

If crystals appear in ampoules with the drug during storage (usually if the temperature drops below 15°C), it is recommended to dissolve them by heating the ampoules in a water bath (the water should boil) and shaking them periodically until the crystals are completely dissolved.

The solution should be completely transparent. If, after cooling it to 36-38°C, crystals do not form, Dioxidin is considered suitable for use.

During the period of treatment with the drug, care should be taken when driving vehicles, engaging in activities that are potentially hazardous to health and life, as well as performing work that requires a high speed of psychomotor reactions.

Analogs

Dioxidin for children

The drug is not intended for the treatment of children and adolescents under 18 years of age. This contraindication is mainly due to the possible toxic effect of hydroxymethylquinoxaline dioxide.

However, in certain situations, when the expected benefit to the child outweighs the potential risks, the doctor may neglect this limitation. If Dioxidin is prescribed, treatment should be carried out in a hospital setting or under the constant supervision of the attending physician.

In pediatrics, Dioxidin solution is most often used to treat ENT diseases, mainly purulent forms of rhinitis or sinusitis. It is considered most appropriate to use a medicine with a concentration of the active substance of 0.5%.

In addition, the solution and ointment can be used to treat wound surfaces. A solution with a concentration of 0.5% is prescribed if the patient has deep lesions.

However, Dioxidin with such a dosage of the active substance should not be used for a long time. Therefore, as the condition of the wound improves, they switch to a 0.1% solution or ointment.

Dioxidin for a runny nose

The drug is not available in the form of nasal drops, therefore, before dripping Dioxidin into the child’s nose, the contents of the ampoule are diluted with a hypertonic solution to obtain a solution with a concentration of hydroxymethylquinoxaline dioxide of 0.1-0.2%.

It is recommended to administer nasal drops for children three times a day, one or two in each nostril, best after instilling vasoconstrictor drugs that reduce tissue swelling and facilitate nasal breathing. When carrying out the instillation procedure, the patient should tilt his head back so that the medicine penetrates as deeply as possible into the nasal passages.

It should be remembered that after opening the ampoule with the medicine, the solution is considered suitable for use within 24 hours. The maximum permissible duration of treatment for a runny nose is 1 week. However, most pediatricians recommend limiting it to 3-4 days.

In parallel with treatment with Dioxidin, it is recommended to use traditional methods of treating a runny nose (warm the nasal passages and rinse them with weak saline solutions) and monitor the air humidity in the room.

Dioxidine in the ear

Dioxidin instillation into the ear is indicated for severe forms of acute inflammation of the middle ear, in cases where the antibiotics prescribed to the child do not give the desired effect.

Before using the solution, it is recommended to thoroughly clean the ear from wax with a cotton swab.

The solution in ampoules is instilled into the ear twice a day. Moreover, for otitis media, the procedures are also supplemented with nasal drops.

The drug is not ototoxic and does not affect the auditory nerve.

Dioxidin for sinusitis

Dioxidine in ampoules is often used in the treatment of infectious processes localized in the paranasal sinuses. For sinusitis, the solution is used in the form of inhalations or as nasal drops. Drops are administered two or three into each nasal passage. The procedures are repeated 2 times a day.

To treat sinusitis, complex drops can also be used, which are prepared using solutions of dioxidine, adrenaline and hydrocortisone. Complex drops are administered one into each nasal passage 4-5 times during the day.

Compound drops are prepared according to a prescription prescribed by a doctor in a pharmacy or at home.

Dioxidin for inhalation

Reviews indicate that prescribing inhalations to children using Dioxidin solution can effectively treat persistent cough. In addition, the use of the medicine helps to disinfect the nasal passages and paranasal sinuses, provokes the death of pathogens in the bronchi and pharynx, and also eliminates nasal congestion and prevents the separation of purulent secretions.

It is recommended to do inhalations with Dioxidin for children using a nebulizer. As a rule, this method is used for persistent bronchitis that cannot be treated with other antibacterial drugs.

For inhalation, a 0.5% solution is prescribed. Before the procedure, it should be diluted with a hypertonic solution in a ratio of 1:2. The duration of inhalation is from 3 to 4 minutes. The frequency of procedures is 2 times a day.

Dioxidin for gargling

The advisability of using a solution for gargling is due to the ability of hydroxymethylquinoxaline dioxide to eliminate infection, clean the infected surface and accelerate the regeneration of the mucous membrane.

These features of the drug contribute to the healing process in case of purulent bacterial infections provoked by microflora sensitive to Dioxidin in case of ineffectiveness of other prescribed antibacterial agents or if they are poorly tolerated by the patient.

Rinsing with the solution is prescribed for pharyngitis, sore throat, tonsillitis, and only in severe cases when other drugs do not help.

To prepare a solution for rinsing, the contents of one ampoule of a one percent solution of Dioxidin are diluted in a glass of warm drinking water, water for injection or isotonic NaCl solution.

A small amount of liquid is taken into the mouth and, throwing the head back, gargle for a few seconds. After this, the solution is spat out, and rinsing is continued until the solution is completely used. The procedure is repeated three times a day.

The course of treatment with rinsing with Dioxidin solution is 5 days (unless otherwise recommended by the attending physician).

During pregnancy

The pharmacological properties of Dioxidin make its use unacceptable during pregnancy and breastfeeding.

The medicine can cause disruption of embryogenesis and negatively affect the development of the fetal nervous system. Absorbed from the surface of the mucous membranes into the systemic bloodstream, it is able to penetrate into breast milk, and through it into the child’s body.

Reviews about Dioksidin

Reviews about Dioxidin are quite contradictory. Most patients to whom it was prescribed describe the drug as a very effective remedy, especially for diseases accompanied by a purulent-septic process.

Negative reviews are due to the fact that the drug is quite toxic (its therapeutic dose is only slightly less than the toxic one), and its use is often accompanied by unwanted side effects.

Reviews of the ointment allow us to conclude that Dioxidin in this dosage form does not cause irritation to the skin, stimulates tissue healing and generally has a beneficial effect on the wound process, however, with prolonged use, microorganisms develop resistance to the drug.

Dioxidin is used primarily as a reserve agent, that is, its help is resorted to only in extreme cases.

The instructions clearly indicate that the drug is intended exclusively for the treatment of adult patients, but it is often used to treat otolaryngological diseases in children.

Despite the fact that Dioxidin does not have an evidence base that would confirm the safety of its use in pediatrics, nasal drops, according to reviews left on the Internet, are a fairly effective remedy for such forms of pathological runny nose as, for example, purulent rhinitis.

Meanwhile, Dioxidin is not included in the standards for the treatment of ENT diseases, and there is no official data on its use as nasal drops. Thus, when prescribing this drug to a child, both the doctor and parents (if they agree with the prescribed treatment regimen) act at their own peril and risk.

It should be noted that until now, the use of the medicine has not been associated with any complications or negative consequences for the child’s body.

Dioxidine price, where to buy

The price of Dioxidin differs depending on the form of release of the drug. For example, the average price of Dioxidin in ampoules with a concentration of hydroxymethylquinoxaline dioxide is 0.5% (this form is used to prepare nasal drops) is rubles.

The cost of packaging ampoules with a 1% solution is from 327 to 795 rubles (depending on the manufacturer and the number of ampoules in the package). Ointment for external use can be purchased for approximately 285 rubles.

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I realized that ointment is better

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Inna: Usually, insomnia occurs for me due to some kind of experience and when you lie down, it’s not.

Olesya: I tried glycine forte, which is more expensive in the price category, but the dosage is the same.

Andrey: Not a word is said about choosing the size of stockings according to a person’s parameters: height, leg size, etc.

Olga: For coxarthrosis of the 2nd degree, I have been injecting for 4 years at the rate (after 6 months), there is no improvement.

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Source: http://medside.ru/dioksidin

Dioxidin: instructions for use

The drug Dioxidin is an antibacterial agent belonging to the quinoxaline group. Used in many areas of medicine.

Release form and composition of the drug

The drug Dioxidin is available in the form of a solution intended for intracavitary and external use. The solution has a concentration of 1% and is available in 10 ml transparent glass ampoules, in cardboard packs with detailed instructions. The contents of the ampoule are sterile; the medicine may have a yellowish or greenish tint.

The main active ingredient of the drug is hydroxymethylquinoxaline dioxide. One ampoule of the drug contains 100 mg of active substance. Water for injection acts as an auxiliary component.

Pharmacological properties of the drug

The drug Dioxidin is a broad-spectrum antibacterial agent, a derivative of quinoxaline. The active substance of the solution has pronounced chemotherapeutic activity against infectious processes caused by Pseudomonas aeruginosa, Proteus vulgaris, dysentery bacillus, salmonella, staphylococcus, streptococcus, gas gangrene pathogens, and Klebsiella. The drug is active even against those bacteria that are resistant to antibiotics and chemotherapy drugs.

With prolonged use of the solution, bacteria can develop immunity and become resistant. When administering the drug intravenously, the dose prescribed by the doctor should be strictly followed. When used externally as a means for treating wounds and purulent foci, it promotes rapid cleansing of the pathological surface from crusts and purulent contents, stimulates the processes of regeneration and epithelization of damaged tissues.

Indications for use

Dioxidin solution is prescribed to patients for the treatment and prevention of the following pathological processes:

  • Inflammatory infectious processes caused by pathological microflora - the drug is prescribed when antibiotics and other chemotherapeutic agents are ineffective;
  • Wound surfaces of varying severity and depth;
  • Trophic ulcers that do not heal for a long period of time;
  • Burns of varying degrees with the addition of a secondary bacterial infection;
  • Treatment of soft tissue phlegmon;
  • Suppurating wound surfaces caused by polio;

Intracavitary administration of the drug Dioxidin is prescribed for the following conditions:

  • Purulent inflammatory processes of the abdominal and thoracic cavity - peritonitis, lung abscess, cystitis, mastitis, phlegmon, postoperative wounds;
  • Complicated otitis;
  • Complicated sinusitis, sinusitis, rhinitis and other pathologies of the nasal cavity.

Contraindications for use

Dioxidin solution can only be used as prescribed by a specialist. Before starting therapy, it is recommended to carefully read the accompanying instructions, since the drug has the following contraindications:

  • Individual intolerance to the drug;
  • Pregnancy and breastfeeding period;
  • Adrenal cortex insufficiency;
  • Severe renal dysfunction, acute renal failure;
  • Children's age up to 12 years.

Method of administration and dosage of the drug

The drug Dioxidin is usually prescribed to patients in hospital settings. The drug is used in many areas of medicine - externally and internally.

If intravenous administration is necessary, the contents of the ampoule with Dioxidin are diluted to the required concentration with sterile physiological sodium hydrochloride solution. The dose and duration of drug therapy is determined by the doctor depending on the diagnosis and severity of clinical symptoms.

Treatment of wound surfaces

If it is necessary to treat open festering or poorly healing wound surfaces, lotions with dioxidine are used. To do this, a sterile gauze pad is moistened with a solution of the drug and applied to the wound. I tightly pack deep wounds with gauze turundas moistened with Dioxidine solution. If there is drainage, up to 100 ml of solution is injected into the wound cavity several times a day as an antiseptic.

To treat wounds caused by osteomyelitis, the wound surfaces are first washed with a 0.5% solution of Dioxidin, and then a gauze pad moistened with a 1% solution of the drug is applied.

The solution can be used to prevent the development of postoperative complications. To do this, the wound surface is treated daily with Dioxidin. In the absence of individual intolerance, this drug can be used for up to 1-2 months with normal tolerance.

Dioxidine in the nose

Dioxidin solution is used in the presence of complicated inflammatory processes in the nasal cavity, in particular for the treatment of sinusitis, sinusitis, frontal sinusitis and other pathologies. The nasal cavity is washed with Dioxidin solution 2-3 times a day, using a syringe for convenience. The drug has an excellent therapeutic effect in complicated sinusitis, when other drugs, including antibiotics, are ineffective. The punctured maxillary sinuses are washed with a solution of the drug 2-3 times a day, after which, if necessary, gauze turundas soaked in the solution are inserted into the nasal cavity.

Dioxidine in the ear

Dioxidin solution is prescribed to patients as an independent medicine or as part of complex therapy for purulent otitis and the spread of the pathological process to the Eustachian tube. In a hospital setting, the patient’s ear cavity is washed with a solution of the drug, after which a cotton or gauze turunda is inserted into the ear for a minute.

Intracavitary administration of the drug

A solution of the drug is injected into the purulent cavity through a catheter or drainage tube. The number of ml varies depending on the volume of the pathological cavity. As a rule, it is enough to inject the drug into the cavity once a day, using a 1% solution of Dioxidin.

The duration of drug therapy is determined by the doctor individually for each individual patient. If well tolerated and without side effects, Dioxidin can be used for up to 2 months, after which a break is taken and, if necessary, the course of therapy is repeated.

Use of the drug during pregnancy and breastfeeding

The use of Dioxidin solution while expecting a child is strictly contraindicated for women. Special studies were carried out, during which it was found that the active substance of the drug is capable of having a mutagenic and teratogenic effect on the development of the fetus in the womb; in addition, the solution is toxic to the embryo and can cause congenital deformities and anomalies.

The use of the drug during breastfeeding is contraindicated, since the active substance can penetrate into breast milk, and then into the baby’s body with food. If Dioxidin therapy is necessary during breastfeeding, it is recommended to interrupt lactation.

Side effects

During drug therapy, patients may experience the following side effects:

  • Chills, headaches, general weakness, convulsions - when the solution is injected into a vein or inside a cavity;
  • When used externally - allergic reactions in the form of burning, skin tightness, dryness, rash, swelling.

In severe cases, the patient may develop angioedema and anaphylaxis.

Drug overdose

With prolonged use of the solution intravenously or inside the cavity, overdose symptoms may develop, which are expressed in suppression of kidney function and disruption of the functioning of vital organs. If too large doses of the drug are accidentally administered orally, the patient should remain under the supervision of specialists with monitoring of important vital parameters. If necessary, symptomatic treatment is carried out.

If the allergic reactions described above develop, the patient is prescribed antihistamines, the dose of Dioxidine is reduced or therapy is stopped completely.

special instructions

The drug Dioxidin is intended only for the treatment of adult patients. Before you start using the solution, you must do a tolerance test. If there are no side effects, the drug can be used for treatment within 4 hours.

The drug is prescribed only in extreme cases in the absence of a therapeutic effect from the use of antibiotics and antibacterial drugs from the group of fluoroquinols, cephalosporins, and carbapenems.

For patients with chronic renal failure, the dose of the drug is selected strictly individually!

When storing ampoules with solution in the refrigerator, precipitation or crystals may form. In this case, before starting therapy, the ampoule is heated in hot water or over boiling water steam until the crystal is completely dissolved. Next, the solution should be cooled to the patient’s body temperature; if during this period crystals do not form again and the solution remains clear, then it can be used for treatment. If crystals form again, the medicine should be thrown away, even if it has not yet expired.

Analogues of the drug Dioxidin

The following drugs are similar in their therapeutic effect to Dioxidin solution:

Before replacing a prescribed drug with its analogue, the patient should definitely consult a doctor, since not all of these drugs have the same therapeutic activity as Dioxidin solution.

Conditions of release and storage

The drug is sold only with a prescription from a doctor. It is recommended to store the solution in a cool, dark place out of reach of children. The expiration date is indicated on the packaging; when it expires, the medicine should be thrown away.

If the integrity of the ampoule is damaged or the solution becomes cloudy, the medicine cannot be used!

The average cost of the drug Dioxidin in ampoules in Moscow pharmacies is 360 rubles per pack of 10 pieces.

Source: http://bezboleznej.ru/dioksidin