Headache from ceftriaxone

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Ceftriaxone. Side effects

About one percent of cases of increased body temperature and the appearance of a febrile state have been recorded. Very rarely, more complex manifestations such as Steven-Johnson syndrome, toxic epidermal necrolysis, exudative erythema multiforme or Lyell's syndrome occur.

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The most interesting thing is that about 5 years ago I was injected with Medaxone (the same as ceftriaxone) and the reaction was normal. So it's better to do tests.

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Source: http://www.tiensmed.ru/news/post_new3792.html

When does Ceftriaxone start working?

Ceftriaxone is a powerful antibiotic that has a wide spectrum of effects. This unique product effectively copes with pathogenic microorganisms that are the causative agents of many diseases dangerous to humans. How long does it take for Ceftriaxone to start working? What is the treatment regimen and dosage? The instructions for use and the attending physician will help you understand these questions.

Indications for use

The list of diseases for which Ceftriaxone is used is very long. This is explained by its effectiveness and unique ability to destroy the structure of the shell of pathogenic microbes, inhibiting their ability to grow and reproduce.

Among the serious diseases that can be treated with Ceftriaxone are:

  • bacterial meningitis;
  • venereal diseases;
  • peritonitis;
  • osteomyelitis;
  • inflammation of the genitourinary system;
  • bacterial ENT pathologies;
  • skin lesions;
  • prostatitis.

With the help of Ceftriaxone, the occurrence of postoperative complications due to bacterial infection is successfully prevented.

Special recommendations for the use of the drug

Ceftriaxone should be used with great caution to treat newborns with high bilirubin levels and patients with enterocolitis.

The speed of action of Ceftriaxone obliges the doctor to carefully monitor the functioning of the patient’s kidneys and liver throughout the course of treatment. You also need to periodically conduct laboratory blood tests.

Features of the action of Ceftriaxone

The drug has antibactericidal properties. It destroys pathogens and blocks the process of cell biosynthesis. The active component stops the work of all important structures of the bacterium, thereby inhibiting its reproduction.

The action of Ceftriaxone is aimed at destroying different strains of bacterial agents, including dangerous pathogens. The drug does not react to the action of an enzyme produced by bacteria. The medicine also actively fights against anaerobic pathogens, Treponema pallidum.

Ceftriaxone is prescribed only after the cause of the disease has been reliably established. The drug is not prescribed if the causative agents of the disease are group D streptococci, methicillin-resistant staphylococci and enterococci.

After intramuscular administration, the active component of Ceftriaxone penetrates into the general bloodstream in a short period of time, with the help of which it is distributed throughout the rest of the biological fluids and tissues of the body. The medicine easily penetrates into organs, all types of tissues, and fiber. When the drug penetrates the spinal cord, its active component begins the active phase of suppressing the reproduction of the causative agent of a dangerous disease - meningitis.

The bioavailability of Ceftriaxone when administered intramuscularly is 100%.

Once in the body, Ceftriaxone begins to act after a relatively short time. The maximum concentration of Ceftriaxone after intramuscular injection is detected within 2-3 hours. With intravenous infusions, the drug reaches its peak concentration at the end of the infusion.

The half-life of Ceftriaxone from the body occurs in 6-9 hours. Half of the amount of antibiotic is successfully excreted from the human body along with urine. Moreover, the structure of the drug does not change at all. The second half of the drug is excreted in bile. The drug undergoes metabolic changes in the intestinal structures and subsequently forms an inactive compound.

Separately, doctors give recommendations regarding the compatibility of Ceftriaxone with alcohol. Antibiotics should not be used together with alcoholic beverages. Such a “neighborhood” can provoke the appearance of some symptoms that will aggravate the therapeutic effect:

  • decreased blood pressure;
  • increased heart rate;
  • spasmodic pain in the abdominal and epigastric region;
  • labored breathing;
  • dyspepsia;
  • changes in the skin on the neck and face;
  • headache.

In case of overdose of Ceftriaxone, symptomatic therapy is used.

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IMPORTANT. The information on the site is provided for informational purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

Source: http://pillsman.org/25821-cherez-skolko-nachinaet-deystvovat-ceftriakson.html

Antibiotics JSC "Biosintez" Ceftriaxone - review

SUPER

Once again I fell ill with a cold. It, in turn, smoothly flowed into a fucking (sorry for the slang) sore throat, sore throat into bronchitis and it all became fixed with sinusitis. It was wonderful. Everything that could hurt hurt))) And when I seemed to overcome the first ailments with my own efforts, the sinusitis did not go away. I started taking antibiotic tablets as prescribed by the doctor. I drank them for seven days and no miracle happened. My head still hurt, but the picture showed that the sinusitis had not gone anywhere, but was sitting securely in its place.

Then my doctor prescribed ceftriaxone with lidocaine. She warned me that the injection was painful, but lidocaine relieved the pain.

When diluted, the powder produces an oily liquid. And with a painkiller in combination, you can endure it. My husband gave the injections) And there were practically no bumps left.

In theory, on the third day you should already feel better, but I was allowed to go only after the final tenth injection. But he let it go.

And everything that accompanied me, from the sores, passed.

But after the first injection, I woke up from a terrible pain in my stomach, and until I started drinking Hilak Forte, I was tormented by terrible pain. Therefore, immediately after taking antibiotics, start drinking something to improve your intestinal microflora. And after you complete the course of ceftriaxone, you need to drink it for at least two more weeks. Because the antibiotic is powerful and destroys everything in its path, both good and bad.

deneve120 recommends Antibiotics JSC "Biosintez" Ceftriaxone

Ceftriaxone is a broad-spectrum antibiotic. It is actively prescribed both in humanitarian medicine and in veterinary medicine.

Ceftriaxone is one of the favorite antibiotics of doctors of all types. It's true. It works great and is cheap. It is easily diluted, but when given an intramuscular injection it is extremely painful, and intravenous injection is also poorly tolerated.

Cannot be used without a doctor's recommendation! (PHOTO)

Ceftriaxone is a very strong and also very dangerous antibiotic, so it is useless to praise it. I hasten to warn you that every second person may have an allegory and complications from this antibiotic, so it will be used strictly under the supervision of a medical professional and after the recommendation of a doctor.

First aid for acute inflammation

Hi all. It so happened that a year ago, after a follicular sore throat, I caught a purulent inflammation of the appendages, suffered for several days, “maybe it will go away on its own,” and then the temperature was 40 and there was acute pain, it was impossible to touch my stomach.

A very painful injection and many side effects. But it helps quickly.

I treated a sore throat with this antibiotic. The doctor prescribed a course for 10 days, 2 injections per day. The drug is effective, the symptoms of the disease began to subside after the first injections, but side effects were not long in coming. I will list in order all the side effects that I had to encounter: 1.

Negative reactions of the body after taking Ceftriaxone

Many people are interested in whether Ceftriaxone has side effects. Antibiotics and antimicrobials are quite widely used in the drug treatment of various inflammatory processes and infectious diseases. Their composition is constantly being improved, making the treatment of infectious diseases more effective. But the question of their side effects is still of great concern to both doctors and patients. A lot of research has already been carried out, and there are ongoing discussions in medical circles. One thing is clear for now: a more effective method of fighting infections than antibiotics has not yet been found. It is worth carefully studying the effects of drugs on the body and using them only as prescribed by a doctor.

A popular third-generation broad-spectrum antibiotic is Ceftriaxone. As most doctors note, the side effects of this drug have a small percentage of manifestations and they are all reversible. According to statistics, only 3 patients out of 100 experience unpleasant consequences of taking Ceftriaxone. Moreover, they all occur in a very mild form. And only 0.5% of patients had severe reactions.

Local reactions

Ceftriaxone is administered into the patient's body only through intramuscular injections or intravenous infusions.

The high activity of this antibiotic, which causes severe tissue irritation, does not allow its use in the form of tablets or capsules. The instructions for use of Ceftriaxone state that the administration of this drug is painful and causes local reactions. Sometimes phlebitis occurs - inflammation of the venous wall, which can be prevented by slow administration of the drug. After injection, a lump may form under the skin.

Allergic reactions

When using Ceftriaxone, special attention should be paid to the possibility of allergic reactions. This may be chills or fever, skin rash and itching, bronchospasm. Less common are eosinophilia, edema, anaphylactic shock, serum sickness and more complex reactions such as erythema multiforme, Stevens-Johnson syndrome and Lyell's syndrome. However, there is no incompatibility of Ceftriaxone with antihistamines. Reactions of the nervous system. Dizziness and migraines (constant headaches) may occur. In some cases, convulsive states were noted. Ceftriaxone negatively affects the condition of the heart muscle and blood vessels. Some patients complained of increased heart rate. Reactions of the hematopoietic organs. Side effects of Ceftriaxone injections on the hematopoietic organs can be:

  1. Hypocoagulation - poor blood clotting, occurs as a result of a decrease in the concentration of plasma coagulation factors, which leads to severe bleeding.
  2. Anemia is a decrease in the content of erythrocytes and red blood cells in the blood.
  3. Leukopenia is a decrease in the concentration of leukocytes, white blood cells. However, in some cases, patients experienced leukocytosis - an increase in white cells in the blood.
  4. Granulocytopenia is a decrease in the number of granulocytes per unit of blood.
  5. Thrombocytopenia is a decrease in the number of platelets per unit of blood.
  6. Lymphocytopenia is a decrease in the number of lymphocytes per unit of blood.
  7. Neuropenia is a decrease in the number of neurophilic leukocytes per unit of blood.

Digestive system reactions

Nausea and diarrhea are the most common side effects of Ceftriaxone on the digestive system.

This antibiotic can also cause constipation and bloating. Some patients complained of abdominal, that is, constant, pain in the abdomen, which went away after discontinuation of the drug. Side effects also occur in the oral cavity:
  • disturbance of taste sensations;
  • stomatitis - expressed in the form of ulcers on the oral mucosa;
  • glossitis is inflammation of the tongue.

Kidney reactions. Due to the use of Ceftriaxone, renal dysfunction may occur. This leads to an increase in the amount of urea in human blood. And also to the appearance of hypercreatininemia and azotemia. Hypercreatininemia is caused by an increase in the amount of creatinine in the blood, and azotemia is caused by an increase in nitrogenous metabolic products. The amount of urine excreted by the kidneys is greatly reduced and may even approach zero. In this case, blood and glucose may appear in the urine. As well as proteins or cellular elements, the so-called cylinders. In a number of children, minor formation of kidney stones was observed after long-term use of Ceftriaxone. But all this was reversible and easily eliminated after discontinuation of Ceftriaxone.

Liver reactions

When using Ceftriaxone, the liver suffers more than all other internal organs. A course of Ceftriaxone significantly disrupts metabolism. In rare cases, a transient increase in the activity of liver transaminases has been noted.

Other reactions

Sometimes, during a course of Ceftriaxone, increased sweating, flushing and increased blood pressure are observed. There have been cases of thrush in women. Ceftriaxone should not be used to treat people who are allergic to the drug itself or its components. For patients with liver and kidney disorders, Ceftriaxone is prescribed in extreme cases. It is also contraindicated in the treatment of newborns if they were born prematurely. When treating pregnant and lactating women, special care must be taken and only done under medical supervision, since ceftriaxone passes into breast milk.

The information published on this site is for reference only. Before using it in practice, be sure to consult your doctor.

Source: http://gidomed.ru/lekarstva/ceftriakson-pobochnye-dejstviya.html

Ceftriaxone - side effects

One of the most popular and effective broad-spectrum antibiotics is Ceftriaxone, the side effects of which should be studied as carefully as the indications before use. Let's consider what precautions should be taken during treatment with this antimicrobial agent.

Side effects of Ceftriaxone

Taking this antibiotic may be accompanied by allergic reactions, namely: hives, itching and rash. In rare cases, exudative erythema multiforme, bronchospasm, or even anaphylactic shock occurs.

The gastrointestinal tract may react to taking the medicine with diarrhea or, conversely, constipation, as well as nausea, and impaired taste. Sometimes side effects of the antibiotic Ceftriaxone manifest themselves in the form of glossitis (inflammation of the tongue) or stomatitis (painful ulcers on the oral mucosa). Patients may complain of abdominal (constant) pain in the abdomen.

The liver reacts specifically to Ceftriaxone: its transaminases can increase activity, as well as alkaline phosphatase or bilirubin. In some cases, pseudocholelithiasis of the gallbladder or cholestatic jaundice may develop.

According to the instructions, side effects of Ceftriaxone may include impaired renal function, which causes an increase in the level of:

  • nitrogenous metabolic products (azotemia);
  • creatinine (hypercreatininemia);
  • urea.

In urine, in turn, the following may appear:

  • glucose (glucosuria);
  • blood (hematuria);
  • so-called cylinders - casts of proteins or cellular elements (cylindruria).

The amount of urine excreted by the kidneys may decrease (oliguria) or reach zero (anuria).

Hematopoietic system reaction

Ceftriaxone injections can also have side effects on the blood-creating organs, which consist of a decrease in blood cells per unit of blood:

  • red (erythrocytes) – anemia;
  • white (leukocytes) – leukopenia;
  • neutrophil leukocytes – neutropenia;
  • granulocytes – granulocytopenia;
  • lymphocytes – lymphocytopenia;
  • platelets – thrombocytopenia.

The concentration of plasma coagulation factors in a unit of blood may decrease, and hypocoagulation (poor blood clotting) may occur, which can lead to bleeding.

At the same time, in some cases, a side effect of Ceftriaxone is leukocytosis - an increase in white cells in the blood.

Local and other reactions

When an antibiotic is injected into a vein, inflammation of its wall (phlebitis) may develop, or the patient will simply begin to feel pain along the course of the vessel. When the medicine is administered intramuscularly, an infiltrate and painful sensations in the muscle sometimes appear.

Nonspecific side effects of taking Ceftriaxone include:

  • headache;
  • candidiasis;
  • dizziness;
  • nosebleeds;
  • superinfection (development of antibiotic resistance, causing one infection to develop into another).

Overdose and compatibility with drugs

In case of overdose, symptomatic therapy is carried out. There is no specific antidote that eliminates the effect of Ceftriaxone; hemodialysis is ineffective. Therefore, you should be very careful with the dosage of the medicine - this should be controlled by a doctor.

Ceftriaxone also has other disadvantages: it interferes with the production of vitamin K, because, like any antibiotic, it suppresses the intestinal flora, so you should not take non-steroidal anti-inflammatory drugs with it - this can increase the risk of bleeding. The medicine is incompatible with ethanol, therefore drinking alcohol during treatment is contraindicated.

Aminoglycosides and Ceftriaxone, acting together, enhance each other's effect (synergy) against gram-negative microbes.

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Source: http://womanadvice.ru/ceftriakson-pobochnye-deystviya

Side effects of the drug Ceftriaxone

Ceftriaxone is an antibiotic of the cephalosporin group used to combat bacterial infections of the abdominal cavity, digestive tract, respiratory tract, bones and joints, genitourinary system, soft tissues, etc. The drug has a wide spectrum of action, but its use can cause unpleasant side effects in a number of patients, associated both with the individual characteristics of the body and with other elements of the therapy.

Possible side effects

Antibiotic treatment usually does not cause serious side effects, but in some patients therapy is associated with unpleasant complications of the condition:

  • allergies - increased body temperature (about 1% of cases), rashes and swelling on the body (2% of patients), bronchospasm, itching, cough, runny nose, anaphylactic shock;
  • from the urinary system, disturbances in the normal functioning of the kidneys, slowdown in urine production and cessation of its excretion are possible;
  • the digestive tract may respond to antibiotic therapy with increased gas formation in the intestines, nausea, vomiting, changes in taste, diarrhea, imbalance of microflora (dysbacteriosis);
  • hematopoietic processes may be disrupted, resulting in an increased number of eosinophils (diagnosed in 5% of patients), leukocytes or platelets;
  • the medicine can cause bleeding from the nasal cavity, dizziness, activation of the Candida fungus and headaches.

Most often, unpleasant local reactions occur. When Ceftriaxone is administered intravenously, severe pain may be observed along the vein, and when administered intramuscularly, pain may occur at the injection site.

Overdose

If you follow the dosage recommended by your doctor, an overdose is unlikely. An error may arise in calculating the amount of medication relative to a person’s weight, especially if we are talking about a child patient. Signs of an excess amount of antibiotic entering the body are:

  • a sharp feeling of nausea;
  • dizziness and severe headache.

With increased dosage over a long period of time, the drug is especially harmful - it causes changes in the blood picture, damage to the heart, liver and kidneys. Ceftriaxone also has a bad effect on the nervous system - the patient becomes irritable and susceptible to depression. The problem of overdose requires an immediate solution - there is no specific antidote, so symptomatic therapy is performed.

Drug Compatibility

Prescribing a course without taking into account drug compatibility with other drugs may have negative consequences:

  • drugs to reduce the degree of platelet aggregation and Ceftriaxone in combination cause a high risk of bleeding;
  • a simultaneous course with loop diuretics leads to the development of toxic effects on the kidneys and the urinary system as a whole;
  • taking with alcohol is prohibited, as this increases the side effects of the drug and increases the load on the digestive and urinary systems.

Contraindications for use

The use of antibiotics is prohibited in the following situations:

  • with individual intolerance;
  • during pregnancy and lactation;
  • in case of serious disturbances in the functioning of the liver or kidneys.

Both adult patients and children can use the product only as prescribed by a doctor, strictly following the described regimen and dosage.

Source: http://myadvices.ru/ceftriakson-pobochnye-dejstviya/

The drug "Ceftriaxone": patient reviews

The drug "Ceftriaxone" is a third generation antibiotic, which is part of the cephalosporin group. It is administered only parenterally, which is the main feature of the medication. The effect of the antibiotic extends to many bacteria that develop in an oxygen environment, and it also affects gram-negative and gram-positive microorganisms. This product is produced in the form of a powder for injection. The medicine is sold in bottles that contain 1 g of antibiotic.

In this article we will look at the instructions for use and reviews for the drug “Ceftriaxone”.

New generation antibiotic

It is noteworthy that human life expectancy has increased significantly since the discovery of antibiotics. Most of the various diseases have become curable only thanks to this group of medicines.

True, pathogenic microorganisms are also constantly evolving and never stop adapting to newly invented drugs. For this reason, scientists are constantly improving their developments, which are designed to completely destroy microbes. One of the most effective groups of antibiotics is the category of cephalosporins. Ceftriaxone itself belongs to the third generation, and at the moment there are 4 in total.

From this we can conclude that it is a fairly new drug, due to which most microbes have not yet had time to adapt to it. This remedy can influence the cell walls of pathogenic microorganisms. "Ceftriaxone" acts on transpeptidases, which are bound through membranes, and breaks peptidoglycan connections, which are essential for the normal state of body cells. Destroys staphylococci, streptococci, E. coli and salmonella. Before starting treatment, a sensitivity test must be performed by a doctor, otherwise its use may be unjustified.

Indications for use

Ceftriaxone is an effective treatment for various bacterial infections, for example:

  • Diseases of the throat, nose and ears.
  • Infections that cause pathology of the bronchi and trachea, which can lead to inflammation of the lungs, the appearance of abscesses and empyemas.
  • Infectious diseases of the dermis and muscles.
  • Bacterial infections of the bladder and kidneys along with inflammation of the prostate and epididymitis.
  • Various diseases of the female genital organs that arise as a result of infections.
  • Diseases of the digestive system and peritonitis.
  • Infection of the circulatory system.
  • Diseases of the musculoskeletal system.
  • The development of meningitis, syphilis, spirochetosis, typhoid and salmonellosis. All these indications are described in detail in the instructions for Ceftriaxone. There are a lot of reviews about this.

In addition to all of the above, such a drug is used to prevent the occurrence of infections after surgical interventions.

Contraindications

"Ceftriaxone" is strictly prohibited for use in the treatment of patients with individual intolerance to this drug or antibiotics from the category of cephalosporins and penicillins. In addition, it is not recommended to use the medicine for pregnant women in the first trimester, as well as for women who are breastfeeding. It is also contraindicated for patients with kidney and liver dysfunction. This is confirmed by doctors’ reviews of Ceftriaxone.

Pharmacokinetics

The highest content of the active substance in the blood will be observed 1 or 2 hours after the injection.

Against this background, over 30 minutes the amount of Ceftriaxone, as a rule, reaches 150 mcg per 1 ml. The drug has great penetrating ability. If the medication is used intramuscularly, its entire amount is fully absorbed by the human body.

For this reason, it becomes possible to cure a significant number of diseases. Such information was obtained as part of studies that were conducted in hospital settings. The substance acts in such a way that the drug penetrates into the tissues of the liver, heart, respiratory organs, and also into the tissues of the gallbladder and musculoskeletal system. In the human body, it interacts with a blood protein called albumin. The concentration of the antibiotic in plasma is insignificant. This indicates instructions for use for Ceftriaxone injections. We'll look at the reviews below.

The drug is able to penetrate the brain of babies. Therefore, it is effective in the treatment of newly born children. Its highest concentration in the spinal cord is usually observed 4 hours after intravenous injection. In adult patients, the amount of the drug in the body increases 2 hours after the procedure and lasts throughout the day.

How to breed

The powder is diluted with a 1% lidocaine solution, but special water for injection can also be used. It is better not to resort to novocaine, since it may cause anaphylactic shock or side effects in the patient.

The finished product is good for 6 hours. It can be stored in the refrigerator. In this case, a day is given for use, but before that it is warmed at room temperature. The drug is administered intravenously and intramuscularly. How often to administer the drug can only be determined by a highly qualified doctor. Therefore, injections are often prescribed to people undergoing hospital treatment.

Side effects from the antibiotic

According to reviews, Ceftriaxone injections generally cause a small number of unwanted effects. But if they occur, you should not interrupt the course of treatment. Less than 2% of patients may, for example, notice a rash on the skin or swelling of any parts of the body along with dermatitis. 6% of patients may experience eosinophilia.

During the use of Ceftriaxone, 1% of cases of increased body temperature and the occurrence of febrile conditions were recorded. It is extremely rare that more serious manifestations, such as Steven-Johnson syndrome, may occur. In addition, adverse reactions can manifest themselves in the form of toxic epidermal necrolysis, exudative erythema multiforme or Lyell's syndrome. But, despite this, almost all reviews about Ceftriaxone are positive.

It is possible that pain and swelling may occur at the site where the injection was made. There is a possibility of phlebitis, which will be associated with intravenous administration of the substance. For intramuscular injection, it is advisable to use an anesthetic drug. Each package contains instructions for Ceftriaxone injections. Reviews are presented below.

Migraine-like pain or dizziness may also occur. It is possible to increase the amount of nitrogen in patients' blood tests. Creatinine will most likely appear in the urine. In very rare cases, children who have been treated with significant amounts of the drug may develop kidney stones.

As a rule, such results are caused by a combination of the use of Ceftriaxone (noted in reviews) and prolonged stay in a supine position. Such phenomena generally do not cause any inconvenience, but have a bad effect on the functioning of the kidneys. Upon completion of treatment, all of these problems go away on their own.

Drug interactions

Ceftriaxone suppresses intestinal flora. As a result, vitamin K synthesis is reduced. Therefore, simultaneous use with drugs that reduce platelet aggregation is undesirable, as there is a risk of bleeding. Use with anticoagulants enhances their effect.

It is also not recommended to use an antibiotic with loop diuretics, as the risk of developing a nephrotoxic effect increases.

Patient reviews

In modern medicine, the trend is that doctors are increasingly prescribing Ceftriaxone injections. Reviews from patients indicate a high degree of effectiveness of this medicine, and they also praise the rapid relief of the general condition with the use of the drug already on the first day after the start of therapy. The drug is usually well tolerated. If there are any side effects, they are limited to diarrhea. But when taken simultaneously with probiotics, this can be avoided.

Disadvantages of the product

The main disadvantage noted in reviews of Ceftriaxone is the severe pain of the injections. In addition, pain persists after some time. Against the background of such procedures, people also write about the long-term progression of some pathologies associated with the condition of the veins.

Patients say in their comments that the antibiotic Ceftriaxone is often prescribed to them for sore throats or prolonged acute respiratory viral infections. They consider it an inexpensive and very effective remedy that can put you on your feet in just a couple of days, and in addition, it is quite easily tolerated by the body.

True, people note that this is only possible with appropriate support, within which patients simultaneously take drugs such as Hilak-Forte or Bifidumbacterin. This perfectly helps to avoid such troubles as the appearance of thrush along with intestinal dysbiosis.

In addition, some patients are advised to stop eating sweets while undergoing treatment with Ceftriaxone. Also, patients are not recommended to use this antibiotic for self-medication, since it has many side effects, and therefore consultation with the attending physician is required.

In general, most reviews about the antibiotic Ceftriaxone are positive, and people praise this antibiotic, calling it an excellent remedy that can cope well with pathogens.

As already mentioned, many patients are very upset by the fact that the injections are extremely painful. So much so that the area where the vaccine is administered is literally torn apart during the procedure. In order to reduce pain, experienced patients recommend diluting the antibiotic with Lidocaine. People report that with the use of the second remedy, an unbearably painful injection turns into an ordinary, not very pleasant, but quite tolerable procedure.

To avoid the persistence of subsequent sensations after the injection, experts advise after the injection to knead the painful area as much as possible for 5-10 minutes. This method will help the medicine to distribute throughout the tissues much faster. In this case, the patient will be able to reduce discomfort, thereby saving himself from the possible appearance of bruises.

Regarding the pain of Ceftriaxone, reviews from adult patients also say that after receiving such injections, their legs almost became paralyzed. People write that they experienced such severe pain that their entire lower body cramped. Therefore, before agreeing to such treatment, you should take this unpleasant consequence into account.

Does not cause allergies

Parents in their comments call it a broad-spectrum antibiotic and praise it for the fact that there are practically no allergic reactions when Ceftriaxone is prescribed to children. There are also reviews on this matter.

People note the relative availability of the drug in comparison with other similar drugs that have the same effect on the body, but are more expensive. Thus, during periods of prolonged viral diseases, with high fever and sore throat, when it is not possible to do without antibiotics, experts admit that they opt for this particular medication. People experienced in the treatment of various infections, who have tried many different drugs with a similar spectrum of action, recommend choosing Ceftriaxone injections. According to reviews, they are ideal for children.

Dysbacteriosis

Patients who have undergone treatment for pneumonia with the drug write that the therapy was completed successfully and the disease was eliminated. However, they warn others that, for all its effectiveness, this antibiotic most often causes dysbiosis along with candidiasis. Like most similar drugs, this drug requires an allergy test, as well as a sensitivity test.

Adverse reactions in pregnant women

During pregnancy, some women sometimes experience water breaking earlier than expected, and contractions may not even begin yet. In such situations, doctors prescribe Ceftriaxone to women in labor in order to prevent the development of severe infectious complications in mother and child. As a rule, if appropriately prescribed, an antibiotic is injected into the expectant mother strictly every 12 hours until birth.

The interval between the premature breaking of water and the actual onset of labor can be up to 10 days. As patients who went through this test write, the antibiotic helped them and their babies, who were born healthy. Women write that they did not experience any infections or fever during the neonatal period while taking the medicine. True, there were side effects in babies in the form of disturbances in the intestinal microflora, as a result of which small patients suffered from severe colic for some time from the very first weeks after their birth.

Conclusion

It is obvious that, according to reviews, Ceftriaxone is an effective drug in the fight against all kinds of bacterial infections. But it is important to note that we must not forget that antibiotics are serious drugs that are prohibited from being used independently without undergoing a preliminary examination and consulting a doctor.

Against the background of uncontrolled use, more and more resistant strains of certain microorganisms are formed, which are difficult to eliminate in the future. Due to the willful use of antibiotics, patients can develop all sorts of negative consequences, which can have a very negative impact on their health. We reviewed reviews of treatment with Ceftriaxone.

Source: http://www.syl.ru/article/351833/preparat-tseftriakson-otzyivyi-patsientov

What does Ceftriaxone injections help with?

Ceftriaxone injections and tablets: instructions for use, analogues

Ceftriaxone is not a commonly used drug for home treatment. It is intended for a course of therapy in a hospital and can only be prescribed by a professional doctor. As you know, any medicine in inept hands can cause harm rather than benefit. Therapy with Ceftriaxone requires special medical training. The drug must be administered by qualified medical personnel, and the course of treatment must be carried out under the supervision of a physician. In this article we will talk about the features of using a new generation antibiotic and what diseases can be overcome with its help.

Did you know that the increase in life expectancy of modern humans is directly related to the discovery of antibiotics? Many previously incurable diseases have disappeared thanks to the use of this particular group of medicines. But pathogenic microorganisms do not sleep either; over time, they have learned to adapt to antibiotics. Therefore, scientists continue research in this area and develop new antibacterial drugs that can effectively cope with a variety of infections. The group of cephalosporins belongs to a new generation of antibiotics, one of its brightest representatives is Ceftriaxone (injections, tablets).

Ceftriaxone - description of the antibiotic

Ceftriaxone is a third-generation cephalosporin antibiotic with a broad spectrum of bactericidal action. The drug is active against anaerobic and aerobic gram-negative and gram-positive microorganisms, and is intended only for parenteral administration (by injection).

The bactericidal effect of the drug is ensured due to the inhibitory effect on the cells of pathogenic microorganisms. Ceftriaxone is able to quickly penetrate the tissues and fluids of the body, and after a short time, a high concentration of the drug is observed in the cerebrospinal fluid and bile. The antibiotic is able to pass through the placenta and enter breast milk.

Up to 65% of the drug is excreted unchanged in the urine, the rest is excreted from the body with bile and stool. Ceftriaxone is widely used in the treatment of various infections and inflammatory processes.

Composition and release form

The manufacturer produces Ceftriaxone in the form of a white powder used to prepare a solution for injection. It is used for intramuscular and intravenous administration. The powder is packaged in glass bottles, each of which contains 500 mg or 1 gram of the drug.

Bottles of 5,10, 50 pcs. Packed in cardboard boxes. The drug is stored in a dark, dry place, out of reach of children, at a temperature not exceeding 20°C. The shelf life is 2 years.

pharmachologic effect

Ceftriaxone is a new generation antibiotic. It is effective against most gram-positive and gram-negative microorganisms that can grow both in the presence of oxygen and in an oxygen-free environment. The antimicrobial effect of Ceftriaxone is due to the suppression of the synthesis of cell membranes of pathogenic bacteria.

The drug has a high penetrating ability, so for the treatment of most infections it is enough to use Ceftriaxone once a day. Already one to two hours after injection of the drug into the muscle, the highest concentration of Ceftriaxone in the blood is observed. When administered intramuscularly, the entire volume of the drug is completely absorbed by the body. After a one-time intravenous administration, the maximum concentration of the drug in the blood is achieved within half an hour after the procedure.

When introduced into the body, Ceftriaxone accumulates in the body in maximum quantities and remains at this level throughout the day. The largest amount of antibiotic is concentrated in the musculoskeletal system, lungs, heart, liver, and gall bladder. The drug is able to penetrate the placental barrier and affect the condition of the fetus; when treating nursing mothers, a certain concentration of the antibiotic is observed in breast milk.

Indications

Ceftriaxone is a broad-spectrum drug used to treat a number of bacterial infections:

  • Respiratory diseases (pneumonia, lung abscess)
  • Infectious diseases of the gastrointestinal tract and biliary tract (cholangitis, purulent cholecystitis, peritonitis).
  • Infectious lesions of soft tissues and skin.
  • Infectious diseases of bones and joints.
  • Infections of the genitourinary system.
  • Sepsis.
  • Microbial lesions of the ENT organs (ear, throat, nose)
  • Bacterial meningitis.
  • Endocarditis.
  • Sexually transmitted infections (gonorrhea, syphilis).
  • Typhoid fever.
  • Lyme borreliosis.
  • Salmonella carriage and salmonellosis.
In addition, Ceftriaxone is used to treat infectious diseases in people with weak immune systems and as a prevention of postoperative complications.
Contraindications for taking Ceftriaxone injections and tablets

The drug is prohibited for use in persons with hypersensitivity to the components of the drug or hypersensitivity to other cephalosporins and penicillins. In addition, the antibiotic should be prescribed with caution in cases where the patient has diseases associated with impaired liver function, kidney function, ulcerative colitis and enteritis. Particular attention is paid to the administration of Ceftriaxone to newborns and premature infants, women during pregnancy and breastfeeding.

During pregnancy, the use of the drug is justified only if the expected effect outweighs the risk of adverse effects on the fetus. In the early stages of pregnancy, when the formation of the organs and systems of the unborn child occurs, the drug is not recommended for use.

This can lead to complications during pregnancy and various developmental disorders in the fetus. If there is a need to use Ceftriaxone during lactation, breastfeeding must be stopped, since the active substance can penetrate into mother's milk.

During therapy with Ceftriaxone, unwanted side effects may occur. If they occur, the course of treatment with the drug must be interrupted. About 2% of patients note the development of allergic reactions: skin rashes, itching, swelling of certain areas of the skin, symptoms of dermatitis and urticaria. Some patients experience feverish conditions and a sharp increase in body temperature. In severe cases, anaphylactic shock may develop.

Injections of the drug are quite painful, so painkillers are used for intramuscular injections. Sometimes a painful swelling occurs in the area where the medication is administered, and with intravenous administration, cases of phlebitis and pain along the vein are observed.

From the central nervous system, convulsive seizures, dizziness, and migraines may occur. Long-term use of the drug can have a negative effect on the heart, blood vessels and be accompanied by increased heart rate and nosebleeds. Possible hematopoietic disorders, accompanied by a decrease in hemoglobin and changes in blood counts.

Antibiotics often have a negative effect on the digestive system. This drug is no exception. Treatment with Ceftriaxone (course of treatment) disrupts the intestinal microflora, which threatens the development of dysbiosis and is accompanied by such manifestations as diarrhea, nausea and vomiting. In some cases, changes in the microflora in women contribute to the development of vaginitis or thrush. Therefore, it is recommended to combine a course of drug therapy with taking medications containing lacto- and bifidobacteria.

In complex cases, manifestations of exudative erythema or toxic epidermal necrolysis occur. There are disturbances in the functioning of the kidneys associated with a ban on drinking liquids and prolonged periods of lying down. With the development of congestion in the gallbladder, non-infectious jaundice may develop.

Instructions for use and dosage of the drug

The instructions for use of Ceftriaxone indicate that the drug can be used exclusively for intravenous and intramuscular injections. The medication is approved for use only in hospital settings.

  1. For the treatment of adults and children over 12 years of age, the dose of the drug is 1-2 g once a day. In difficult cases, the daily dose of antibiotic can be increased to 4 grams.
  2. When treating newborns under 2 weeks of age, the dosage is calculated as follows: mg of the drug per 1 kg of weight. The injection is given once a day.
  3. For infants and children under 12 years of age, the antibiotic is administered once a day at the rate of 1 mg per 1 kg of weight. For children whose weight exceeds 50 kg, the dose of the drug is calculated as for adults.
  4. When treating meningitis in young children, Ceftriaxone is used once a day at a dose of 100 mg per 1 kg of weight.
  5. For microbial infections of the muscles and dermis in children, the daily dose should not exceed 2 g at a dosage of mg per kilogram of weight. When administered intravenously at a dose of more than 50 mg per 1 kg of body weight, the drug is infused drip over 30 minutes.

The dosage of the drug is calculated based on the diagnosis and depends on the severity of the disease. For some diseases, such as the treatment of gonorrhea, just one dose of 250 mg is sufficient. When treating syphilis, the duration of treatment depends on the stage of the disease and averages from 14 to 40 days. The duration of treatment with Ceftriaxone for other diseases is usually two weeks.

To prevent infections in the postoperative period, a one-time administration of the drug one hour before surgery is sufficient. Since intramuscular injections of Ceftriaxone are quite painful, it is recommended to dilute the powder in lidocaine. When performing intravenous infusions, the drug is diluted with water for injection.

How and in what proportion to dilute Ceftriaxone?
  1. How to dilute Ceftriaxone with lidocaine? If you need to prepare a solution for injection into a muscle, 500 mg of powder is dissolved in 2 ml of a 1% lidocaine solution. If the bottle contains 1 g of the drug, you will need 3.5 ml of lidocaine solution (1%).
  2. How to dilute Ceftriaxone with water? For injection into a vein, 500 mg of powder is diluted in 5 ml of water. If you need to dilute 1 g of antibiotic, you will need 10 ml of sterile water for injection. The prepared solution is injected into the vein very slowly, the procedure takes from 2 to 4 minutes.

All freshly prepared antibiotic solutions are stable both physically and chemically and can be stored at room temperature for 6 hours.

Interaction with other drugs

Ceftriaxone should not be used in combination with medications containing ethanol and liquid preparations of other antibiotics. When this antibacterial agent is combined with non-hormonal anti-inflammatory drugs, bleeding may develop.

When used simultaneously with diuretics, there is a risk of kidney damage.

The average price for 1 bottle of Ceftriaxone is rubles.
Analogs

Ceftriaxone has many analogues. Here are just a few of them:

special instructions

During treatment with Ceftriaxone, alcohol consumption is unacceptable, as serious complications are possible:

The drug negatively affects the intestinal microflora, preventing the synthesis of vitamin K, so elderly and weakened patients are prescribed this vitamin. With long-term treatment, monitoring the condition of the liver and kidneys and blood counts is necessary.

In some cases, during treatment with the drug, ultrasound of the gallbladder may show darkening, and the patient may complain of pain in the right hypochondrium. However, drug therapy should be continued, since these phenomena disappear after a course of treatment.

Ceftriaxone should be used with great caution in newborns whose bodies contain excess bilirubin.

During therapy with Ceftriaxone, the risk of anaphylactic shock should be taken into account and, if necessary, emergency care should be provided.

During pregnancy, the use of this drug is undesirable, since the components of the drug penetrate the placenta and have a negative effect on the fetus. But there are conditions when it is impossible to do without the use of an antibiotic. These are infectious diseases of the genitourinary system such as urethritis, cystitis, proctitis. In severe cases, with the development of gonococcal sepsis, the use of the drug is vital and the positive effect of treatment will significantly exceed the possible risk to the fetus.

Reviews about the treatment

Last fall I had a severe exacerbation of cystitis. I cried from sharp pains, could not go to the toilet, and did not sleep at night. The temperature rose, there were chills, and in such a feverish state I went to see a urologist. The doctor directed me to donate the tank. culture to determine the pathogen and its sensitivity to antibiotics.

Before this, I treated attacks of cystitis with various antibiotics; during an exacerbation, I tried to take the usual medications, but they did not work. It turned out that the causative agent of the disease was resistant to the antibiotics with which I was treated. I was prescribed Ceftriaxone injections.

They admitted him to the hospital and injected him intramuscularly 2 times a day. The injection was very painful, although it was given at the same time as lidocaine. But already on the 3rd day I felt relief, and a week later I was discharged from the hospital. The antibiotic is very powerful, has a strong effect on the stomach, and after treatment dysbacteriosis developed. I had to restore the microflora with bifidumbacterin.

Review #2

I was injected with Ceftriaxone when I was admitted to the hospital with double pneumonia. The injections were given intramuscularly. I am allergic to lidocaine, so I injected it with saline twice a day: morning and evening. I am a fairly patient person, but I went into the procedure as if it were an execution. I have never experienced such pain from injections in my entire life. They gave me 10 injections in total, after each I felt sick, dizzy, nauseous, and my blood pressure dropped.

At the injection site, the skin was very swollen and painful. It was canceled only after consulting a doctor; I refused to be treated with this drug. They prescribed other antibiotics, which I tolerated much more easily. I try not to think about treatment with Ceftriaxone.

We came across this antibiotic when my daughter and I were in the hospital for pyelonephritis. I heard unflattering reviews about him and feared for my daughter when Ceftriaxone was prescribed. I asked first to do a test for this drug, because I was afraid of an allergic reaction and anaphylactic shock. Everything turned out to be fine. They injected it along with a painkiller, but still my daughter cried a lot and complained that the injection was very painful.

It’s good that the injection was given once a day. Improvement came quite quickly. In total we received 10 injections. After the course of treatment, I had to take medications with lactobacilli, as my daughter constantly complained of nausea and abdominal pain. Now everything is back to normal, the child feels well. Nothing reminds me of the disease, there are no relapses.

Ceftriaxone (antibiotic): description of the drug and therapeutic effect

Few people know that the increase in human life expectancy is most directly related to the invention of antibiotics.

Most of the severe pathologies have subsided thanks to the use of this group of drugs. However, pathogenic microorganisms do not sleep either. They have learned to adapt to the action of antibacterial drugs.

That is why scientists do not stop there; they do not stop conducting research and inventing new medicines that help cure a wide variety of diseases.

Cephalosporins belong to a new generation of antibacterial drugs. One of the most commonly used representatives of this group is Ceftriaxone (an antibiotic). The medicine is intended for treatment in inpatient settings. At home, especially if a person does not have a medical education, it is not recommended to use the product.

Ceftriaxone is a 3rd generation broad-spectrum cephalosporin antibacterial agent. The medicine is effective against aerobic and anaerobic gram-negative and gram-positive microorganisms. The product is intended exclusively for parenteral use (via intramuscular or intravenous injections).

The medicine has pronounced bactericidal properties. The action of the antibiotic Ceftriaxone is achieved by inhibiting bacterial cells and other pathogens.

The medication is prescribed to both adults and children. The antibiotic is effective in the treatment of pathologies of inflammatory and infectious nature, in particular sinusitis, bronchitis, sore throat and pneumonia. However, it is not recommended to use it without the knowledge of a specialist. Reviews of the drug and its therapeutic effect are mostly positive, since the medicine is effective and, moreover, is sold at a very affordable price.

The antibiotic Ceftriaxone, according to the instructions, has a high penetrating ability, so for therapy it is enough to use it once a day. One to two hours after using the product, the highest levels of the product in the blood are observed. When the drug is administered intramuscularly, complete absorption of the drug by the body is noted.

When the drug is administered intravenously, the highest content of the composition in the blood is observed after an hour. Ceftriaxone, an antibiotic, accumulates in the body in large quantities after administration and remains at this level throughout the day.

The product is produced exclusively in powder form. The active ingredient of the drug is ceftriaxone. The powder can be diluted with either lidocaine or water for injection.

Why are Ceftriaxone injections prescribed: indications and contraindications, dosage

The medicine is effective in the treatment of diseases of inflammatory and infectious nature. Only the attending physician can prescribe the drug. In addition, injections should only be carried out by a qualified specialist.

Many people are interested in the question: “Why are Ceftriaxone injections prescribed?”

The drug is effective for:

  • wound infections;
  • meningitis;
  • sepsis;
  • infectious pathologies of the dermis, bones and joints;
  • gonorrhea;
  • cholangitis;
  • salmonellosis;
  • pneumonia;
  • bronchitis;
  • endocarditis;
  • Lyme disease;
  • syphilis;
  • typhoid fever.

The medicine is well tolerated by patients. Side effects are rare. However, there are cases in which Ceftriaxone injections are not prescribed. The drug is not used to treat people with individual intolerance, severe pathologies of the liver and kidneys, ulcerative colitis, enteritis. The medication is not prescribed to infants with hyperbilirubinemia.

Ceftriaxone is prescribed with the utmost caution to pregnant and breastfeeding women, as well as small children, and only when the expected therapeutic effect outweighs the likelihood of an adverse effect.

In the first trimester of pregnancy, Ceftriaxone injections are also not prescribed, since at this time the organs and systems of the fetus are being formed. The use of medication in the early stages of gestation is fraught with various disorders in the development of the child.

Inappropriate use of the drug, improper dilution or abuse of Ceftriaxone can lead to the appearance of:

  • fever and chills;
  • bronchospasm;
  • skin rashes;
  • itching;
  • anaphylactic shock;
  • anemia;
  • flatulence;
  • bowel disorders;
  • pain in the epigastrium;
  • nausea;
  • vomiting;
  • dysbacteriosis;
  • anuria;
  • oliguria;
  • pain along the vein or at the injection site;
  • phlebitis;
  • nosebleeds;
  • pre-fainting states;
  • headaches;
  • candidiasis.

During therapy you should refrain from drinking alcohol. Drinking alcoholic beverages is fraught with a significant decrease in blood pressure and intestinal spasms.

The drug is produced exclusively in powder form. There is no tablet form of Ceftriaxone. To administer the drug intramuscularly, it must be diluted with lidocaine, and for intravenous administration - with water for injection.

If you need to make a solution for intramuscular administration, 500 mg of the drug must be diluted in a solution of 1% lidocaine, in two milliliters. For intravenous administration, it is necessary to dilute 500 mg of the drug in 5 ml of water for injection. Fresh solution remains stable and effective for six hours.

The drug is prescribed in the following doses:

  • adults and children over twelve years old - 1 mg per day. In case of severe infectious processes, the daily dose is doubled;
  • a newborn up to two weeks is prescribed using one kilogram of weight, once a day;
  • infants and children under 12 years of age are prescribed mg of powder per kilogram of weight, once a day;
  • a child whose weight is more than 50 kg is prescribed an adult dosage.

In order to prevent the development of complications after surgery, one milligram of the drug is prescribed before surgery.

The dose of the medication is selected taking into account the pathology and its severity. Sometimes, for example, with gonorrhea, just a single dose of 250 mg is enough. When treating syphilis, the duration of the course depends on the stage of the disease. The average course duration is from two weeks to one and a half months.

The duration of the course for other pathologies is on average half a month.

The first injection of a medicine with lidocaine should be carried out with extreme caution, since the anesthetic can provoke a severe allergic reaction. Before starting therapy, it is necessary to do a test. A little solution, about 0.5 ml, must be injected intramuscularly and wait half an hour. If there are no negative manifestations, it is necessary to inject the remaining product into the other buttock.

The safest way to test sensitivity to a drug is to perform a scratch test. On the inside of the forearm, several shallow scratches are made with a scarifier. A solution is applied to them, literally a couple of drops. The result is assessed after a few minutes. If there is no significant redness or swelling, you can use the drug.

Do not use the medicine without the knowledge of a specialist. It is important to know why Ceftriaxone injections are prescribed. Detailed information is provided in the instructions.

The medicine has many analogues; the doctor can replace Ceftriaxone with the following drugs:

Ceftriaxone injections: instructions for use

Ceftriaxone injections

Ceftriaxone is an antibacterial drug, contains detailed instructions for the use of injections, belongs to the group of antibiotics of the cephalosporin class.

Ceftriaxone has an antibactericidal effect, which is achieved by influencing the process of synthesis of protein components that make up the membranes of pathogenic bacterial cells.

The drug is a universal antibacterial agent, most active against:

  • gram-positive bacteria (streptococci);
  • gram-negative bacteria (Enterobactercloacae, Haemophilusparainfluenzae, etc.);
  • anaerobic bacteria.

In appearance, ceftriaxone is a yellowish or white powdery substance, finely crystalline, characterized by low hygroscopicity. Available in two versions:

  • in the form of a solution intended for injection;
  • in the form of a solution for infusion treatment.

It is not produced in other variants (tablets, syrups, etc.).

The powder is placed in glass vials, which can contain from 0.25 to 2 g of ceftriaxone sodium salt. When injected with Ceftriaxone, the components of the drug are easily absorbed and distributed throughout the body through the bloodstream. Ceftriaxone penetrates best into joint tissue, bone tissue, skin tissue, and organs located in the abdominal cavity. If the meningeal membranes are damaged or inflamed, the drug may penetrate into the cerebrospinal fluid. The drug is completely eliminated from the body in 6-9 hours through the kidneys.

Indications for ceftriaxone injections include various bacterial infections:

  • syphilis;
  • presence of soft chancre;
  • infections affecting joint tissue, tissue of the abdominal organs, urinary tract and bones;
  • typhoid fever;
  • salmonellosis;
  • diseases of the respiratory tract, upper or lower;
  • borrelosis;
  • in case of infection in case of severe burns and wounds.

Ceftriaxone has an antibactericidal effect

Injections of the antibiotic ceftriaxone are prescribed to people with weak immune systems or to prevent postoperative infection in the patient's body.

Ceftriaxone is generally safe for human health. There are only 2 absolute contraindications: individual intolerance to the drug or the presence of susceptibility to other antibacterial medications. Ceftriaxone injections should be prescribed with caution to pregnant women, women during breastfeeding, children (especially premature ones), if there is renal failure in the body, or with diagnosed colitis caused by taking an antibacterial drug.

How to use Ceftriaxone

Before giving Ceftriaxone injections, you should read the instructions immediately in order to choose the correct dosage of the medicine and the method of preparing the solution.

According to the instructions, the optimal dose for newborns (less than 2 weeks) is mg per 1 kg of weight daily. In children older than 2 weeks and up to 12 years, the dosage should be up to 80 mcg. As soon as the child’s weight exceeds 50 kg, an adult dose of the drug is suitable for them - 1-2 g. The entire daily dose of the drug can be administered once, or divided into several and given an injection 2 times a day. A more precise dosage of the drug, depending on the condition of the sick person and the characteristics of his body, is determined in each specific case by the doctor supervising the treatment.

Ceftriaxone is administered intravenously or intramuscularly. If the dosage is more than 50 mcg per 1 kg of weight, then it is recommended to administer the medicine by intravenous infusion, the duration of each procedure is up to half an hour.

If the dosage is more than 50 mcg per 1 kg of weight, ceftriaxone is administered intravenously.

The duration of the course of treatment with the drug depends, first of all, on the type of infection and the degree of its complexity. For bronchial meningitis in infants and children under 12 years of age, the dosage of the drug is 100 mcg, administered once a day. The duration of the course varies from 4 to 12 days. For skin infections, the dosage is up to 75 mcg per 1 kg of weight, but not more than 2 g. In case of an overdose of the drug, symptomatic treatment is carried out.

For gonorrhea, the patient is prescribed a single injection of 250 mcg of the drug. To protect the patient from postoperative infection, an injection of 1-2 g of the drug is prescribed half an hour before surgery.

The solution for infections or infusion can only be prepared immediately before use, observing the following rules:

  1. Intramuscular injections: 500 mg of Ceftriaxone must be diluted with 2 mg of lidocaine solution (1%). For 1 g of medicine you will need 3.5 ml of lidocaine solution. It is recommended to inject 1 g of solution into the gluteal muscle per injection; it is better not to exceed it.
  2. Intravenous infections: pure water is used instead of lidocaine solution. For 0.5 mg of Ceftriaxone you will need 5 ml of water, for 1 g - 10 ml. The solution for intravenous injection must be administered slowly, over at least 2-3 minutes.
  3. For intravenous infusion, dilute 2 g of powder in a calcium-free solution: sodium chloride (0.9%), levulose (5%), glucose (5%). The medicine in an amount of more than 50 mcg is administered dropwise over 30 minutes.

You cannot prepare solutions and administer them yourself. After preparation, the prepared solution can only be used for the next 6 hours, after which it loses chemical and physical stability.

Additional information about the drug Ceftriaxone

Today, doctors are increasingly prescribing Ceftriaxone to patients for infectious diseases. This medicine is considered one of the most effective among doctors. It allows you to cure the disease in the shortest possible time, while the risk of side effects is minimal. Ceftriaxone is safe and is prescribed to pregnant women (exception: 1st trimester) and children. During lactation, it is also permissible to prescribe the drug, provided that the child is switched to infant formula for the duration of treatment. Therefore, the drug can be considered not only effective, but also safe for humans.

Patients' reviews of Ceftriaxone injections are mostly positive. They note that the medicine is very effective, and already on the first day of the course there is a significant improvement in overall well-being. The only drawback of the drug is noticeable pain during the injection and for some time after it.

Therefore, before giving an injection to a child, it is recommended to apply Emla - a cream, a local anesthetic - to the injection site. This will help reduce the pain a little. If the injection is given intravenously, the pain spreads along the vein.

The disadvantage of the drug is noticeable pain during the injection and for some time after it.

Ceftriaxone can be purchased at a pharmacy, but only as prescribed by your doctor. If you need to purchase Ceftriaxone in injections, then the price of the drug is low: rubles for 1 ampoule. The price of the medicine varies in different cities, points of sale, and depends on the manufacturer of the medicine, although the difference is insignificant. But in general, the price can be considered affordable, which is also an advantage.

The shelf life of the drug is 2 years. But if after a course of treatment there are Ceftriaxone ampoules left, you should not use them in the future without a doctor’s recommendation.

Ceftriaxone is a potent antibiotic, and its uncontrolled use can only harm the body: bacteria that are not susceptible to the effects of the drug spread in the body.

Ceftriaxone - instructions for use

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general information

Ceftriaxone is a third-generation cephalosporin antibiotic. The peculiarity of this drug is the exclusively parenteral route of administration, that is, ceftriaxone in injections is the only dosage form of release.

The antibiotic blocks the production of a special substance by the bacterial cell - murein, which is part of its shell. Due to this, lysis and death of the microorganism occurs.

Ceftriaxone is active against many pathogenic agents:

  • Staphylococcus (including the golden strain);
  • Streptococci;
  • Escherichia coli;
  • Protea;
  • Pseudomonas aeruginosa;
  • Klebsiella;
  • Moraxella;
  • The causative agent of meningitis;
  • Shigella and other gram-positive and gram-negative bacteria.

However, many bacteria are resistant to ceftriaxone. The instructions for use strongly recommend that you conduct a certain analysis - a sensitivity test - before starting treatment with this drug. Otherwise, therapy may not be effective.

The biological availability of the drug by any route of administration is 100%. After injection into the muscle, the maximum concentration in the blood plasma is observed after 2.5 hours, with intravenous administration - at the end of the injection.

50% of the drug is excreted unchanged by the kidneys. The remaining amount is inactivated in the liver and excreted along with bile.

Instructions for use

EXPAND INSTRUCTIONS CEFTRIAXONE

Composition and release form

Powder for the preparation of solution for injection is white or white with a yellowish tint. 1 bottle contains ceftriaxone (in the form of disodium salt) 500 mg, 1 or 2 g;

Bottles of 10 ml and 20 ml.

Ceftriaxone is a third generation cephalosporin antibiotic with a broad spectrum of action. It has a bactericidal effect, inhibiting the synthesis of the cell membrane of microorganisms. In vitro inhibits the growth of most gram-positive and gram-negative bacteria. Resistant against b-lactamases.

Active against gram-positive aerobic bacteria: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, Streptococcus bovis; gram-negative aerobic bacteria: Aeromonas spp., Alcaligenes spp., Branhamella catarrhalis (forming and non-forming beta-lactamases), Citrobacter spp., Enterobacter spp., (some strains are resistant), Escherichia coli, Haemophilus ducreyi, Haemophilus influenzae (including . strains producing penicillinase), Haemophilus parainfluenzae, Klebsiella spp. (including Klebsiella pneumoniae), Moraxella spp., Morganella morganii, Neisseria gonorrhoeae (including penicillinase-producing strains), Neisseria meningitidis, Plesiomonas shigelloides, Proteus mirabilis, Proteus vulgaris, Providencia spp., Salmonella spp. (including Salmonella typhi), Serratia spp. (including Serratia marsescens), Shigella spp., Vibrio spp. (including Vibrio cholerae), Yersinia spp. (including Yersinia enterocolitica), Pseudomonas aeruginosa (some strains); anaerobic bacteria: Bacteroides spp. (including some strains of Bacteroides fragilis), Clostridium spp. (except Clostridium difficile), Fusobacterium spp. (except Fusobacterium mortiferum and Fusobacterium varium), Peptococcus spp., Peptostreptococcus spp.

Methicillin-resistant strains of Staphylococcus spp., Enterococcus spp., Bacteroides fragilis (strains producing b-lactamases) are resistant to the drug.

Bacterial infections caused by susceptible microorganisms:

  • peritonitis;
  • sepsis;
  • meningitis;
  • infections of the abdominal organs (inflammatory diseases of the gastrointestinal tract, biliary tract, including cholangitis, empyema of the gallbladder);
  • diseases of the upper and lower respiratory tract (including pneumonia, lung abscess, pleural empyema);
  • bone and joint infections;
  • skin and soft tissue infections;
  • urinary tract infections (including pyelonephritis);
  • gonorrhea;
  • infected wounds and burns.

Prevention of postoperative infection. Infectious diseases in persons with weakened immune systems.

Hypersensitivity to ceftriaxone; pregnancy (first trimester).

Directions for use and doses

Ceftriaxone is administered intramuscularly or intravenously (stream or drip).

For adults and children over 12 years of age, the average daily dose is 1-2 g of ceftriaxone 1 time per day. In severe cases or in cases of infections caused by moderately sensitive pathogenic microorganisms, the daily dose can be increased to 4 g (2 g 2 times a day).

For newborns (up to two weeks of age) the dose is mg/kg/day.

For infants and children under 12 years of age, the daily dose is mg/kg.

In children weighing 50 kg or more, adult doses are used. A dose of more than 50 mg/kg body weight must be administered as an intravenous infusion (drip). The duration of treatment depends on the nature of the disease.

For bacterial meningitis in infants and young children, the initial dose is 100 mg/kg 1 time/day. The maximum daily dose is 4 g.

For the treatment of acute gonorrhea, the dose is 250 mg, once intramuscularly.

To prevent infections in the preoperative and postoperative periods, 1-2 g of ceftriaxone is administered before surgery.

In case of renal failure (creatinine clearance less than 10 ml/min), the daily dose of ceftriaxone should not exceed 2 g.

In case of severe impairment of liver and kidney function, as well as in patients on hemodialysis, it is necessary to monitor the concentration of ceftriaxone in the blood plasma, because their rate of excretion may decrease.

Allergic reactions: about 1% - urticaria, fever, chills, eosinophilia, rash, itching, exanthema, allergic dermatitis, exudative erythema multiforme, edema, anaphylactic shock.

From the digestive system: nausea, vomiting, stomatitis, glossitis, diarrhea, pseudomembranous enterocolitis, cholestasis, increased activity of liver transaminases, hyperazotemia, hypercreatininemia, increased urea content.

From the side of the central nervous system: headache, dizziness.

From the hematopoietic system: leukopenia, neutropenia, granulocytopenia, thrombocytopenia, hemolytic anemia.

Local reactions: with intravenous injection - phlebitis, pain along the vein, with intramuscular injection - pain at the injection site.

Other: superinfection (including candidomycosis, mycosis of the genital organs); oliguria, hypocoagulation.

The drug is prescribed with caution to newborns (including premature infants) due to the high risk of developing hyperbilirubinemia in ulcerative colitis.

In case of simultaneous severe renal and liver failure, the concentration of the drug in the blood plasma should be regularly determined.

With long-term treatment, it is necessary to regularly monitor the peripheral blood picture, indicators of the functional state of plasma and kidneys.

In rare cases, an ultrasound of the gallbladder reveals dark spots that disappear after discontinuation (even if this phenomenon is accompanied by pain in the right hypochondrium, it is recommended to continue prescribing an antibiotic and carrying out symptomatic treatment).

Ceftriaxone and aminoglycosides are synergistic against many gram-negative bacteria.

Possible simultaneous administration with metronidazole, fluoroquinolones, vancomycin, rifampicin (but not in the same syringe).

When used simultaneously with loop diuretics (for example, furosemide), renal dysfunction is not observed.

Pharmaceutical interactions Pharmaceutically incompatible with solutions containing other antibiotics.

Store in a dry place, protected from light at a temperature of 15-25°C.

Shelf life: 2 years.

Freshly prepared solutions of ceftriaxone are physically and chemically stable for 6 hours at room temperature and for 24 hours when stored in a refrigerator at a temperature of 2° to 8°C.

Indications for use

Bacterial infections respond well to treatment with the antibiotic ceftriaxone. The instructions highlight the following pathogenic conditions in which it is advisable to prescribe this particular drug:

  • 1. Infectious and inflammatory processes: peritonitis, typhoid fever, purulent cholangitis and salmonellosis.
  • 2. Respiratory tract diseases respond well to treatment with the antibiotic ceftriaxone. Indications for its use are as follows: pneumonia and lung abscess, severe bronchitis.
  • 3. Infections of the urinary tract (pyelonephritis and cystitis) and genital organs (gonorrhea).
  • 4. Ceftriaxone has found use in the treatment of meningitis.
  • 5. Prescribed for life-threatening conditions of the patient - sepsis, endocarditis, Lyme disease.
  • 6. Ceftriaxone is the antibiotic of choice for the treatment of bacterial skin infections, infected wounds and burns, and skin lesions due to syphilis.
  • 7. Prescribed in the postoperative period to prevent possible bacterial complications.

Contraindications

The drug is well tolerated and rarely causes side effects. However, in some situations it is strictly forbidden to use ceftriaxone - injections of the drug can cause significant harm to the body.

  • 1. The use of this medication is contraindicated in case of individual intolerance to cephalosporins, penicillins and carbapenems. This is fraught with the development of an allergic reaction, and its worst manifestation – anaphylactic shock.
  • 2. A relative contraindication is severe liver and kidney disease.
  • 3. The first trimester of pregnancy is the period when the use of ceftriaxone is undesirable.
  • 4. It is not prescribed during breastfeeding, since the concentration of the drug in milk is quite high, which can affect the baby’s well-being.

Ceftriaxone is prescribed with special caution to children with hyperbilirubinemia (jaundice of newborns), with intestinal diseases (colitis and enteritis) associated with taking antibiotics.

Dosage

  • Русский
  • Adult patients and children over 12 years of age (or weighing more than 40 kg) are prescribed ceftriaxone at a dosage of 1 gram per day. You can split this dose into two doses - inject 0.5 grams every twelve hours.
  • In severe cases of the disease, the daily amount of medication increases to 2-4 grams.
  • To prevent complications in the postoperative period, 1 gram of the drug is administered before surgery.

The duration of therapy is from 4 to 14 days.

Ceftriaxone antibiotic

The drug ceftriaxone can cause a number of side effects:

  • Digestive system disorders: nausea, unpleasant taste in the mouth, vomiting, increased gas formation, diarrhea, stomatitis. Possible icteric staining of the skin and sclera, development of inflammation of the large intestine - colitis and dysbiosis in children.
  • Allergic reactions - hives, redness and itching of the skin, swelling. The most dangerous conditions that develop when taking an antibiotic are anaphylactic shock and serum sickness.
  • An increase in body temperature and the development of a febrile state - chills, agitation, insomnia, confusion.
  • Formation of sand in the kidneys (temporary condition).
  • Increased eosinophils in the blood.

During the treatment period, the use of ethyl alcohol is strictly prohibited. Drinking alcohol can cause severe intestinal spasms and a drop in blood pressure.

Ceftriaxone injections

This drug is available in powder form for injection. Its appointment is possible only after examination by the attending physician and passing general tests. Since the drug can only be administered intravenously or intramuscularly, treatment is best carried out in a hospital. If this is not possible, then it is worth inviting a nurse to carry out the procedure, who will tell you how to dilute ceftriaxone.

For intramuscular injection, the drug should be diluted with lidocaine (or another anesthetic). For intravenous administration, the basis is exclusively water for injection (in double volume - 500 mg of the drug is dissolved in 5 ml, and 1 g in 10 ml of liquid).

Ceftriaxone tablets

Due to the fact that antibiotic injections are very painful, many patients ask the question: “Can ceftriaxone be used in tablets?” Yes, taking a ceftriaxone tablet would significantly alleviate the plight of patients.

But ceftriaxone is not available in tablets. There is only one form of release - powder in bottles of various shapes and colors.

How to dilute Ceftriaxone (lidocaine)

To prepare an intramuscular injection, it is recommended to use a 1% lidocaine solution. Fresh solution is suitable for use within 6 hours when stored at room temperature. It is allowed to store the prepared solution in the refrigerator for a couple of days. Before use, the drug must be warmed to room temperature.

Let's look at how to dilute ceftriaxone with lidocaine to obtain different doses of the drug:

  • If you have been prescribed 1 gram of the drug, then to prepare the injection you will need 4 ml of 1% lidocaine - 2 ampoules and a bottle of antibiotic containing 1000 mg of the drug.
  • To prepare 0.5 grams of antibiotic, dissolve the contents of the bottle (500 mg) in 2 ml of 1% lidocaine (1 ampoule).
  • If a single dosage of the drug is 250 grams, then the bottle should be diluted as in the previous case - 1 ampoule of diluent per 1 bottle (500 mg). The resulting contents should be drawn into two identical syringes - each will contain the required dose of the drug.

Ceftriaxone for children

  • Русский
  • The dose of ceftriaxone for children under one month of age is 50 mg/kg per day.
  • For children under 12 years of age, an individual dosage is selected, the guideline for which is the child’s body weight. No more than 80 mg/kg can be administered per day.

The first injection of ceftriaxone with lidocaine must be carried out very carefully, since this anesthetic can cause a severe allergic reaction. Before treatment, you need to do a test - inject a small amount of the diluted drug (0.5 ml) into the muscle and monitor the child’s condition. If there are no negative effects within 30 minutes, the remaining dose should be administered into the other buttock.

The safest is the scarification test - shallow scratches are applied to the inside of the forearm using a scarifier. Apply a few drops of solution to them. And evaluate the result after a few minutes - in the absence of pronounced redness and swelling, you can administer the drug without fear.

Analogs

There are many drugs from various pharmaceutical companies, the active ingredient in which is the antibiotic ceftriaxone. Among them are Rocephin, Megion, Torocef, Cefaxon, Biotraxon, Longacef, etc.

It is very convenient when the antibiotic is sold immediately with a solvent. Many analogues of ceftriaxone include 1% lidocaine - these are the drugs Rocifen and Rosin. The advantages of these drugs are as follows:

  • There is no need to purchase additional solvent;
  • The lidocaine included in the kit is dosed and ready to dilute the antibiotic - you just need to draw the drug into a syringe and add it to the bottle.

The only drawback of such drugs is their high cost (compared to other ceftriaxone analogues).

Reviews

Today, the trend is that doctors are increasingly prescribing the drug ceftriaxone. Reviews from patients indicate the high effectiveness of the drug, rapid relief of the general condition already on the first day of starting therapy.

Reviews of ceftriaxone note the only drawback - the intense pain of the injection both during the procedure and after some time. When performing intravenous injections, pain is noted along the vein.

But it is worth remembering one immutable rule: antibiotics are serious drugs that cannot be used independently, without prior examination and consultation with a doctor. As a result of uncontrolled consumption, more and more resistant strains of microorganisms develop, which in the future are difficult to eliminate. Due to the willful use of antibiotics, patients develop various consequences, which has an extremely negative impact on their health.

Source: http://privivkinfo.ru/ukoly/ceftriakson-ot-chego-pomogaet-ukoly.html