Bactroban for the nose

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Bactroban - instructions for use, reviews, analogs and release forms (2% ointment, including nasal) of a medicinal product for the treatment of infections of the nose and skin (furuncle, eczema, nasopharyngitis) in adults, children and pregnancy.

Table of contents:

Compound

In this article you can read the instructions for use of the drug Bactroban. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Bactroban in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Bactroban in the presence of existing structural analogues. Use for the treatment of infections of the nose and skin (furuncle, eczema, nasopharyngitis) in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Bactroban is a broad-spectrum antibiotic for external and local use (including nasal or intranasal application). Mupirocin (the active ingredient of the drug Bactroban) is produced by the microorganism Pseudomonas fluorescens.

Inhibits protein synthesis in the bacterial cell through reversible binding to isoleucyl-tRNA synthetase, which prevents the inclusion of isoleucine in protein chains under construction.

When used in minimal inhibitory concentrations, mupirocin has a bacteriostatic effect, and when used in higher concentrations, it has a bactericidal effect.

Due to the specific mechanism of action and unique chemical structure, there is no cross-resistance with other antibiotics. With adequate use of mupirocin, the risk of the emergence of resistant strains of microorganisms is small.

Bactroban is active against gram-positive aerobic microorganisms: Staphylococcus aureus (staphylococcus) (including strains resistant to methicillin and producing beta-lactamases), Staphylococcus epidermidis, other coagulase-negative species of Staphylococcus, Streptococcus spp. (streptococcus aureus); gram-negative anaerobic microorganisms: Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Branhamella catarrhalis, Pasteurella multocida, Proteus mirabilis (Proteus), Proteus vulgaris, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, Bordetella pertussis.

The following are resistant to the drug: Corynebacterium spp., Enterobacteriaceae spp., gram-negative non-fermenting rods, Micrococcus spp.

Mupirocin + excipients (ointment for external use).

Mupirocin calcium + excipients (nasal ointment).

Mupirocin practically does not penetrate through intact skin. If absorbed through damaged skin, mupirocin is metabolized to a microbiologically inactive metabolite - monic acid - and is quickly excreted from the body by the kidneys.

Mupirocin, after intranasal administration, enters the systemic circulation when used in newborns and premature infants, without causing any undesirable effects indicating intolerance to the drug.

  • treatment of primary skin infections: impetigo, folliculitis, furunculosis (including boils of the external auditory canal and auricle), ecthyma;
  • treatment of secondary skin infections: infected eczema, infected trauma (abrasions, insect bites), minor (not requiring hospitalization) wounds and burns;
  • prevention of bacterial infections and their complications resulting from small wounds and cuts;
  • local infections of the nasal cavity caused by microorganisms sensitive to mupirocin, including carriage of Staphylococcus aureus (including methicillin-resistant strains).

Ointment for external use 2%.

Nasal ointment 2%.

There are no other dosage forms, be it cream or gel.

Instructions for use and method of use

The ointment is applied using an applicator (reusable tube). After treating the surface of the mucous membrane, the nasal passages should be tightly compressed, which ensures uniform distribution of the ointment throughout the nasal mucosa.

The course of treatment is 3-5 days. The drug should not be used for more than 10 days without reassessing the condition. It should not be mixed with other medicinal products for intranasal use to avoid dilution of the ointment and, consequently, a decrease in antibacterial activity or a possible change in the stability of the intranasal ointment.

Directions for use: apply a small amount of ointment, approximately the size of a match head (approximately 30 mg of ointment), into each nasal passage 2 times a day for 5 days.

Ointment for external use

The ointment is applied externally 2-3 times a day. A small amount of ointment is applied to the affected area of ​​skin; a bandage may be applied on top. The duration of treatment is up to 10 days, depending on the severity of the lesion. If there is no effect after 5 days of treatment, it is recommended to re-evaluate further treatment tactics taking into account the dynamics of clinical indicators.

In children: there are no restrictions on the use of the drug. The effectiveness and safety of the ointment was studied in patients aged 2 months and older as part of fundamental clinical programs.

In patients with impaired liver function, no dosage adjustment is required.

In elderly patients, no dosage adjustment is required.

After applying the drug to the skin, wash your hands thoroughly.

  • burning, itching at the site of application of the drug;
  • erythema;
  • dry skin;
  • edema;
  • contact dermatitis;
  • allergic skin reactions at the site of application - swelling, rash;
  • allergic reactions from the mucous membrane;
  • generalized allergic reactions.
  • hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

Currently, there is insufficient data on the use of Bactroban during pregnancy, so the use of the drug is possible only when the expected benefit of therapy outweighs the possible risk to the fetus.

Excretion of the drug into breast milk is unlikely; however, the use of the drug is possible if the expected benefit of therapy for the mother outweighs the possible risk for the infant.

There are no restrictions on the use of the drug in children. The effectiveness and safety of the ointment was studied in patients aged 2 months and older as part of fundamental clinical programs.

Use in elderly patients

In elderly patients, no dosage adjustment is required.

Do not apply ointment to mucous membranes and drainage areas.

Avoid getting the ointment in your eyes. In case of contact, rinse thoroughly with water until all remaining ointment is removed.

In rare cases of allergic reactions or significant irritation of the skin when using Bactroban ointment, treatment should be stopped, the affected area should be rinsed with water to remove any remaining ointment, and alternative antibacterial therapy should be prescribed.

As with other antibacterial drugs, long-term use of Bactroban ointment can lead to excessive growth of insensitive microorganisms.

With caution: macrogol (an additional component of the drug) - polyethylene glycol - can be absorbed through the wound surface or through other damage to the skin and excreted by the kidneys. Macrogol-based ointments should not be used on large surfaces in conditions accompanied by increased absorption of polyethylene glycol, especially with moderate and severe renal failure.

Impact on the ability to drive vehicles and operate machinery

There were no negative effects on the ability to drive a car or operate machinery.

Bactroban ointment cannot be combined with other drugs for external use due to the risk of its dilution, which is manifested by a decrease in antibacterial activity and a potential loss of stability.

No other drug interactions were noted.

Analogs of the drug Bactroban

Structural analogues of the active substance:

Source: http://instrukciya-otzyvy.ru/1220-baktroban-po-primeneniyu-analogi-maz-nazalnaya-infekciya-nosa-kozhi-furunkul-ekzema.html

Bactroban is the only nasal antibiotic without side effects!

The most serious problem in the treatment of purulent-inflammatory diseases of the nose and sinuses are staphylococcal infections that are resistant to standard antibacterial therapy. The main threat is posed by methicillin-resistant strains of Staphylococcus aureus, which used to be the most common causative agents of hospital infections. But recently there has been an increase in the number of their carriage in out-of-hospital settings. Considering the severity of such infections and the resistance of their pathogens to most antibiotics, the issue of developing antibacterial drugs active against such pathogens is urgent. Today, the most prominent representative of this group is Bactroban nasal ointment, which is produced by the English pharmaceutical company SmithKline Beecham.

>> The site presents an extensive selection of medications for the treatment of sinusitis and other nasal diseases. Enjoy it for your health! <

A good therapeutic effect is the result of the unique composition of Bactroban

The active ingredient in Bactroban is mupirocin. Due to the specific action and special structure of the molecule, it does not cause the development of resistance (resistance) of pathogens to it. Bactroban 2% ointment blocks the formation of protein in bacterial cells and has two effects:

  • bacteriostatic – stops the growth and reproduction of infectious agents;
  • bactericidal - causes the death of bacteria.

Bactroban nasal ointment is active against the following strains:

  • Staphylococcus aureus (including methicillen-resistant pathogens);
  • Staphylococcus epidermidis;
  • streptococcus;
  • coli;
  • hemophilus infection.

The effectiveness of antibacterial ointment against these infections has been confirmed by numerous clinical trials.

A number of gram-negative bacteria, as well as Pseudomonas aeruginosa, are resistant to the use of Bactroban. In some cases, to identify resistance, it is necessary to perform a culture from the throat and nasal mucosa.

When should you resort to Bactroban treatment?

Indications for the use of Bactroban are any infections of the nasal cavity that are caused by infectious agents sensitive to mupirocin:

Due to the fact that sinusitis develops in the paranasal sinuses, the penetration of ointment into these cavities from the nose is difficult. But there is no sinusitis without concomitant purulent rhinitis. The use of Bactroban ointment in the nasal cavity will significantly reduce the bacterial load and accelerate the onset of the positive effect of treatment.

It is also important that Baktroban causes the death of Staphylococcus aureus, the carriage of which in the nasal cavity is asymptomatic. The basis for treatment in such cases should be culture to identify the pathogen.

Bactroban is allowed even when other medications are contraindicated!

According to the instructions, Bactroban nasal ointment is approved for use by children from the first days of life (including premature infants). After administration into the nose, the drug is absorbed from the mucous membranes in small quantities and is not capable of causing any unwanted reactions in the body.

There is no data on the use of the drug during pregnancy and lactation, because no clinical trials can be conducted on pregnant and lactating women. But preclinical studies of Bactroban did not show a negative effect on the fetus or the woman’s body.

The only contraindication to the use of Bactroban is individual intolerance to the components. It can be expressed in the appearance of burning of the nasal mucosa, swelling, and skin rash. If such reactions occur, you should stop using the drug and consult a doctor immediately.

Bactroban has virtually no side effects

12 clinical trials were devoted to negative reactions of Bactroban. In all of them, the incidence of side effects was less than 0.1%. The only negative effect on the human body when using Bactroban was the development of allergic reactions from the skin (rash, itching) or mucous membranes (burning, dryness), which occurred extremely rarely.

This reaction was due to individual intolerance to mupirocin or auxiliary components. The drug can be called hypoallergenic and is recommended for people suffering from allergic diseases (nasal hay fever, atopic dermatitis, bronchial asthma).

Instructions for use of Bactroban nasal ointment

Bactroban is used only in the nasal mucosa area. To achieve a good bacteriostatic and bactericidal effect, the following simple steps should be taken:

  1. Clear your nose by blowing your nose.
  2. Apply 30 milligrams of ointment (the volume is equal to the size of a match head) to the mucous membrane of each nasal passage.
  3. Press the nasal passages tightly against the septum to properly distribute the ointment on the surface of the nasal mucosa.

The procedure must be performed twice a day. The course of therapy lasts on average from 3 to 5 days. The drug should not be used for more than 10 days without assessing the change in condition.

Other drugs for intranasal use should not be added to the ointment or used immediately after applying other drugs to the nasal area, as this may reduce the antibacterial activity.

Why should not Bactroban be used for prevention?

In the instructions for Bactroban, the indications for use do not indicate the prevention of nasal diseases, therefore, it cannot be used independently for preventive purposes. The prophylactic use of Bactroban in a hospital setting can be prescribed by a doctor to reduce the risk of developing hospital-acquired infections in patients. Taking such measures on your own at home is strictly prohibited.

The most common reason for the development of bacterial resistance to antibiotics is the irrational and inadequate use of the latter. Infectious agents begin to get used to a constant concentration of the antimicrobial agent and change their structure, becoming insensitive to it.

Frequent use of Bactroban unnecessarily, as well as independently exceeding the course of treatment without a doctor’s advice, can lead to the development of an infection that will have to be treated not with local antibacterial ointments, but with oral or intravenous antibiotics.

Rational use of Bactroban in short courses does not cause the development of bacterial resistance. If there are no effects from use, treatment should be stopped and consult a specialist.

Why is it useless to look for analogues of Bactroban?

Like most unique modern drugs, Bactroban nasal ointment has no analogues. But there is an ointment of the same name, also containing mupirocin, used to treat skin diseases (eczema, pyoderma, psoriasis and others).

When purchasing Bactroban at a pharmacy, be sure to specify which ointment you need. In addition to the described nasal form, there is Bactroban ointment for use on the surface of the skin. Despite the fact that it also contains mupirocin in a 2% concentration, it is not suitable for use on the nasal mucosa due to the content of other excipients.

Analyzing the ointments for intranasal use presented on the pharmaceutical market, you can find that there are not so many of them. All nasal ointments can be divided into three groups:

  • antibacterial (Bactroban);
  • herbal (Pinosol, Doctor Theiss, Evamenol);
  • antiviral (Oxolinic ointment, Grippferon);

Surprisingly, Baktoroban is the only ointment for intranasal use that contains an antibiotic that can destroy pathogenic bacteria. All other intranasal ointments can be used in the complex treatment of nasal diseases, as well as for prevention during unfavorable epidemiological conditions.

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Where can I order Bactroban nasal 2%; 3 years

It’s strange, just six months ago I took Bactroban at the pharmacy. Now it is generally not available in all pharmacies.

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Bactroban

Description current as of 04/19/2016

  • Latin name: Bactroban
  • ATX code: D06AX09
  • Active ingredient: Mupirocin
  • Manufacturer: SmithKline Beecham PLC (UK)

Compound

  • 1 gram of Bactroban ointment for external use includes 22 mg of mupirocin. Additional substances: macrogol 3350, macrogol 400.
  • 1 gram of cream (Bactroban krem) for external use contains 22 mg of mupirocin. Additional substances: stearyl alcohol, xanthan gum, cetomacrogol-1000, liquid paraffin, phenoxyethanol, cetyl alcohol, benzyl alcohol, water.
  • 1 gram of Bactroban nasal ointment contains 20 mg of mupirocin. Additional substances: white paraffin, softizan 649.

Release form

  • Bactroban ointment for external use is white in color and has a uniform structure. 15 or 5 grams of ointment in an aluminum tube - one tube with an aluminum tip in a cardboard pack.
  • White, homogeneous cream for external use. 15 grams of cream in an aluminum tube - one tube with an aluminum tip in a cardboard pack.
  • Bactroban nasal ointment is white. 3 grams of ointment in an aluminum tube - one tube with a plastic tip in a cardboard pack.

pharmachologic effect

Antibacterial, bactericidal effect.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Broad-spectrum antibiotic for local external use. Mupirocin is secreted by the bacterium Pseudomonas fluorescens.

It inhibits protein synthesis in the bacterial cell through temporary binding to the enzyme isoleucyl-tRNA synthetase, resulting in the inclusion of isoleucine in the synthesized protein chains.

When used in minimal inhibitory concentrations, it has a bacteriostatic effect, and in high concentrations it has a bactericidal effect.

Due to the specific mode of action and rare chemical structure, cross-resistance with other antibiotics does not occur. When used correctly, the risk of developing resistant strains is small.

Acts on aerobic gram-positive pathogens - Staphylococcus aureus and epidermidis, other coagulase-negative representatives of the genus Staphylococcus, representatives of the genus Streptococcus; anaerobic gram-negative pathogens - Neisseria gonorrhoeae and meningitidis, Haemophilus influenzae, Branhamella catarrhalis, Proteus mirabilis and vulgaris, Pasteurella multocida, Citrobacter freundii, Enterobacter cloacae and aerogenes, Bordetella pertussis.

Drug-resistant microorganisms: representatives of the genus Corynebacterium, genus Enterobacteriaceae, genus Micrococcus, non-fermenting gram-negative cocci.

Pharmacokinetics of ointment for external use

Mupirocin penetrates poorly through intact skin, and when absorbed through the surface of a wound or burn, it is metabolized to monic acid (an inactive metabolite) and is quickly evacuated from the body by the kidneys.

Pharmacokinetics of intranasal ointment

After intranasal administration, it penetrates into the systemic bloodstream when used in newborns, without causing undesirable reactions. Mucosal absorption accounts for less than 1% of the applied dose, which is excreted in the urine in the form of monic acid.

Indications for use

Indications for use of external ointment

  • Treatment of primary skin infections: folliculitis, impetigo, furunculosis, ecthyma.
  • Treatment of secondary skin infections: infected, infected injuries, eczema, minor burns and wounds.
  • Prevention of bacterial complications arising from minor wounds and cuts.

Indications for use of intranasal ointment

  • Local infections of the nasal cavity caused by microorganisms sensitive to the drug.

Contraindications

  • Allergy to medication components.
  • Ointments containing macrogol cannot be used on large surfaces in conditions characterized by increased absorption of polyethylene glycol, mainly in renal failure.

Side effects

In general, Bactroban ointment is well tolerated. Rarely, allergic skin reactions may occur in the area of ​​application: rash or swelling. Even more rarely, burning, itching in the area of ​​application, erythema, swelling, dry skin, contact dermatitis are possible. Generalized allergic phenomena occur in episodic cases.

Instructions for use of Bactroban (Method and dosage)

External ointment Bactroban, instructions for use

The ointment is used externally up to three times a day. A small volume of ointment is squeezed out of the tube and applied to the affected area of ​​the skin; a bandage may be applied on top. After using the drug, you should wash your hands well. The average duration of therapy (depending on the severity of the diagnosis) is no more than 10 days. If there is no effect after 5 days of drug therapy, it is recommended to change treatment tactics taking into account the dynamics of clinical data.

Instructions for using the cream are completely identical to the instructions for the ointment described above.

Intranasal ointment Bactroban, instructions for use

The ointment is administered using an applicator. To do this, a small volume of medication (a ball about 2 mm in diameter) is injected into each nasal passage twice a day. The nasal passages must be compressed tightly, causing the ointment to be distributed more evenly throughout the nasal mucosa.

The duration of treatment is approximately 3-5 days. It is prohibited to use the drug for more than 10 days in a row without assessing the effectiveness of treatment. It is also prohibited to mix Baktroban with other products for intranasal use due to the possible dilution of the ointment and a decrease in antibacterial activity or a change in its stability.

Overdose

There is no data on the possibility of drug overdose.

Interaction

The described medicine should not be combined with other external drugs due to the risk of its dilution, which may cause a decrease in antibacterial activity and loss of stability of the dosage form.

Terms of sale

Storage conditions

Store at room temperature. Keep away from children.

Best before date

special instructions

It is forbidden to apply the external agent to the mucous membranes and treat the tissues around the drainage.

It is necessary to avoid getting the medicine into the eyes, and if this does happen, the eye must be thoroughly rinsed with clean water until the remaining ointment is completely washed away.

In very rare cases of the development of allergic reactions or skin irritation after using the drug, it is recommended to stop treatment, rinse the affected area with plenty of clean water and prescribe an alternative antibacterial treatment.

Long-term use of the drug can lead to strong growth of insensitive flora.

There was no negative effect of the drug on the ability to drive vehicles.

Analogs

Analogues of Bactroban for external use: Altargo, Baneocin, Bonderm, Chitosan-Ghent, Levomycetin.

For children

This category of patients has no restrictions on the use of the medicine.

During pregnancy and lactation

The use of the drug during these periods under the supervision of a physician cannot be ruled out.

Reviews about Bactroban

The instructions allow the use of Bactroban nasal ointment for children. The reviews are no different from the reviews of adults. The ointment helps well with all the pathologies listed in the indications and causes almost no adverse effects.

Bactroban price, where to buy

The price of external ointment 15 g in Russia can range from 220 to 420 rubles, and the price of Bactroban nasal ointment can reach rubles.

In Ukraine, the price of the release form for external use in a 15 gram tube is equal to hryvnia. The nasal release form of the same name costs on average hryvnia.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Ukraine Ukraine

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Education: Graduated from Vitebsk State Medical University with a degree in Surgery. At the university he headed the Council of the Student Scientific Society. Advanced training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".

Work experience: Worked in a general medical network for 3 years as a surgeon (Vitebsk Emergency Hospital, Liozno Central District Hospital) and part-time as a district oncologist and traumatologist. Worked as a pharmaceutical representative for a year at the Rubicon company.

Presented 3 rationalization proposals on the topic “Optimization of antibiotic therapy depending on the species composition of microflora”, 2 works took prizes in the republican competition-review of student scientific works (categories 1 and 3).

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Source: http://medside.ru/baktroban

"Bactroban" ointment for children: instructions for use

Bactroban is a local antibacterial agent often prescribed to adults for purulent rhinitis and skin infections. But is it possible to treat children with this drug and how to do it correctly?

Bactroban is produced in two versions:

  1. Ointment intended for external use. It is represented by a white homogeneous substance. This form is sold in a tube containing 5 or 15 g of the drug.
  2. Nasal ointment. This is also a homogeneous white mass. It is sold in a 3 gram tube.

Compound

In both versions of Bactroban ointment, the active ingredient is mupirocin, presented in a concentration of 2%, but the auxiliary ingredients are different.

The nasal ointment uses a paraffin base to which softisan 649 is added. Bactroban for external use includes two types of polyethylene glycol (macrogol 400 and 3350).

Operating principle

The main component of any form of Bactroban is an antibiotic obtained from bacteria of the type “fluorescent pseudomonas”. This substance blocks protein synthesis in microbial cells, as a result of which they stop reproducing and die.

The drug is effective against:

  • Staphylococcus aureus.
  • Staphylococcus epidermidis.
  • Streptococci.
  • Gonococcus.
  • Haemophilus influenzae.
  • Meningococcus.
  • Pasteurell.
  • Protea.
  • Enterobacter.
  • Citrobacter.
  • Whooping cough stick.

Corynebacteria, anaerobic microorganisms, micrococci and enterobacteria are insensitive to the drug.

Indications

Nasal ointment is prescribed for bacterial rhinitis and nasopharyngitis, as well as for carriage of staphylococcus. The reason to prescribe Bactroban dermatological ointment may be:

  • Impetigo.
  • Boils.
  • Folliculitis.
  • Bacterial complications of abrasions, insect bites and other skin injuries.
  • Burns.
  • Eczema.

This form is also prescribed for prophylactic purposes if there are minor abrasions, wounds or cuts, wanting to prevent their suppuration.

At what age is it allowed to take it?

Instructions for use of intranasal ointment for children contain information that the product can be safely used from 12 years of age. However, the doctor can prescribe such a medicine for younger children, if there are reasons for this. In this case, the dosage must be adjusted.

Contraindications

Bactroban should not be used if you are hypersensitive to this drug. Ointment for external treatment is also prohibited from being used on mucous membranes. If the drug accidentally gets into your eyes, it should be washed off immediately with a large volume of water.

Side effects

In isolated cases, ointment in the nose can provoke inflammation of the mucous membrane. Ointment applied externally sometimes causes burning or itching at the site of application. You may also experience a feeling of dryness and rawness after treatment.

Rarely, topical application leads to an allergic skin reaction, which is often local, but very rarely systemic. In addition, if the product is used for too long, it can cause a decrease in the sensitivity of the pathogen and its active growth.

Instructions for use and dosage

Treatment with Bactroban is carried out twice a day, but sometimes the doctor may prescribe three times. Approximately the size of a match head is used to lubricate the inner surface of each nostril with nasal ointment (use a cotton swab for application), and then squeeze the wings of the nose to distribute the drug evenly. The dermatological form is applied to the affected skin, and, if necessary, an aspetic bandage is applied on top.

It is not recommended to mix the ointment used in the nose with other agents, as this may affect the stability of the medicine and reduce its antibacterial effect.

The duration of treatment with nasal ointment is 3-5 days, and the drug for external treatment can be used for up to 10 days. Dermatological ointment should not be used longer than this period.

Overdose and interaction with other drugs

There are no data on exceeding the dose of Bactroban and the effect of this drug on treatment with other medications.

Terms of sale

To purchase Bactroban, you must have a prescription from your doctor. You can buy nasal ointment for rubles.

Storage conditions and shelf life

Tubes with Bactroban should be kept out of the reach of children, and the optimal storage temperature is considered to be below +25 degrees Celsius. From the date of release, nasal ointment should be used for 3 years, and the shelf life of Bactroban for external treatment is 2 years.

Reviews

There are many positive reviews about the use of Bacroban, which note that the product in the form of a nasal ointment helped with rhinitis or protected the child from respiratory infections during the epidemic season. Among the disadvantages of the drug, the small volume of the tube and its high cost are usually mentioned.

Analogs

Instead of Bactroban, you can use another drug containing mupirocin. This may be Bonderm or Supirocin ointment. Both of these medications are intended for use on the skin.

If you need to replace nasal ointment, your doctor may prescribe medications with a similar therapeutic effect:

  • Pinosol. This herbal remedy for the common cold is available in the form of drops, nasal cream and nasal ointment, prescribed from the age of 2 years. There is also a spray form that is used in children over 3 years of age.
  • Evamenol. This ointment, containing levomenthol and eucalyptus oil, can be prescribed for rhinitis in children over two years of age.
  • Aqua Maris. This product based on sea water helps to moisturize the mucous membranes and cope with a runny nose. It can be replaced by similar drugs Marimer, Fluimarin, Morenasal, Doctor Theiss allergol sea water, Salin, Physiomer and others.

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Bactroban nasal ointment - official instructions for use

on medical use of the drug

REGISTRATION NUMBER: П№/01

TRADE NAME: BACTROBAN ®

INTERNATIONAL NON-PROPENTED NAME: mupirocin

DOSAGE FORM: nasal ointment

Active ingredient: mupirocin 20.0 mg (as mupirocin calcium 21.5 mg).

Excipients: white soft paraffin, softizan 649.

The ointment is white or almost white.

PHARMACOTHERAPEUTIC GROUP: antibiotic for topical use

Mechanism of action. Mupirocin is a local antibiotic. Mupirocin inhibits isoleucyl transfer RNA synthetase, disrupting protein synthesis in the bacterial cell.

Due to its specific mechanism of action and unique chemical structure, mupirocin does not show cross-resistance with other antibiotics.

When mupirocin is used correctly, the risk of the emergence of resistant strains of microorganisms is small. When used in minimal inhibitory concentrations, mupirocin has bacteriostatic properties, and in higher concentrations, ¾ bactericidal properties.

Antimicrobial activity: in vitro effective against Staphylococcus aureus (including methicillin-resistant strains), Staphylococcus epidermidis, Streptococcus species, and also against gram-negative microorganisms: Haemophilis influenzae and Escherichia coli. Other gram-negative microorganisms are less sensitive, and strains of Pseudomonas aeruginosa are resistant to mupirocin.

Efficacy against the listed microorganisms has been clinically confirmed.

Pharmacokinetics. Mupirocin, after intranasal administration, enters the systemic circulation when used in newborns and premature infants, without causing any undesirable effects indicating intolerance to the drug. Absorption of mupirocin through the mucosa (less than 1% of the applied dose is excreted by the kidneys in the form of miniic acid).

Local infections of the nasal cavity caused by microorganisms sensitive to mupirocin, including carriage of Staphylococcus aureus (including methicillin-resistant strains).

Known hypersensitivity to any of the components of the drug.

USE IN PREGNANCY AND LACTATION

There are no data on the use of the drug during pregnancy and breastfeeding. However, preclinical studies of the drug did not reveal any negative effects on pregnancy or embryonic development.

The ointment is applied using an applicator (reusable tube). After treating the surface of the mucous membrane, the nasal passages should be tightly compressed, which ensures uniform distribution of the ointment throughout the nasal mucosa.

The course of treatment is 3 – 5 days. The drug should not be used for more than 10 days without reassessing the condition. It should not be mixed with other medicinal products for intranasal use to avoid dilution of the ointment and, consequently, a decrease in antibacterial activity or a possible change in the stability of the intranasal ointment.

Dosage regimen. Apply a small amount of ointment, approximately the size of a match head (approximately 30 mg ointment), into each nasal passage twice a day for five days.

In 12 clinical studies, the incidence of adverse reactions was less than 0.1%. Isolated reports of the development of adverse reactions have been received (less Adverse reactions by organs and systems are listed below, indicating the frequency of their occurrence. Definition of frequency: very often (>1/10), often (>1/100, but 1/1000, but 1 /10,000, but From the immune system: very rarely: local hypersensitivity reactions.

From the respiratory tract: sometimes: allergic reactions from the mucous membrane.

To date, there have been no reports of drug overdose.

INTERACTIONS WITH OTHER MEDICINES AND OTHER INTERACTIONS

Avoid contact with eyes. In case of contact with eyes, rinse with plenty of water until all remaining ointment is removed.

INFLUENCE ON THE ABILITY TO CONCENTRATE ATTENTION.

No negative effects on these functions were detected.

Nasal ointment 2%. 3 g in an aluminum tube coated on the inside with epoxy resin varnish, with a plastic tip and a screw cap made of high-density polyethylene. 1 tube along with instructions for use in a cardboard box.

Do not take the drug after the expiration date indicated on the package.

Store at a temperature not exceeding 25°C.

Keep out of the reach of children.

MANUFACTURER. SmithKline Beecham PLC, UK.

Registered address: SmithKline Beecham PLC UK, Manor Royal, Crawley, West Sussex, RH10 9QJ, United Kingdom

For more information about the drug, please contact:

CJSC GlaxoSmithKline Trading, Moscow, st. Krylatskaya, house 17, building 3, floor 5 Business Park “Krylatskie Hills”

Source: http://medi.ru/instrukciya/baktroban_1036/

Bactroban ® (Bactroban ® )

Active substance:

Content

Pharmacological group

Nosological classification (ICD-10)

3D images

Composition and release form

in tubes of 3 g; 1 tube in a box.

in aluminum tubes of 15 g; 1 tube in a box.

Description of the dosage form

Ointment for external use: a homogeneous ointment of white or almost white color.

Characteristic

Mupirocin is an antibiotic that is produced by fermentation of the microorganism Pseudomonas fluorescens .

pharmachologic effect

Suppresses isoleucine transfer RNA synthetase, which leads to the cessation of protein synthesis in the bacterial cell. Due to the specific mechanism of action and unique chemical structure, mupirocin does not show cross-resistance with other antibiotics (if the drug is used correctly, the risk of the emergence of resistant strains is small).

Pharmacodynamics

At minimal inhibitory concentrations it has bacteriostatic properties, and at higher concentrations it has bactericidal properties. Spectrum of antibacterial activity in vitro :

- gram-positive aerobes: Staphylococcus aureus (including strains resistant to methicillin and producing beta-lactamases), Staphylococcus epidermidis and other coagulase-negative Staphylococcus spp. , Streptococcus spp. ;

- gram-negative anaerobes: Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Branhamella catarrhalis, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, Bordetella pertussis ;

- insensitive: Corynebacterium spp. , species of the family Enterobacteriaceae , gram-negative non-fermenting rods, Micrococcus , anaerobes.

Pharmacokinetics

It is characterized by poor permeability through intact skin. If absorbed through damaged skin, it is metabolized to microbiologically inactive monic acid and quickly excreted by the kidneys.

Indications of the drug Bactroban ®

Intranasal ointment: carriage of staphylococci (including multidrug-resistant and methicillin-resistant strains of Staphylococcus aureus ).

Dermatological ointment: treatment of primary skin infections - impetigo, folliculitis, furunculosis (including furuncle of the external auditory canal and auricle), ecthyma; secondary skin infections - infected eczema, infected injuries (abrasions, insect bites), minor (not requiring hospitalization) wounds and burns; prevention of wound infection after minor cuts, wounds and minor abrasions.

Contraindications

Hypersensitivity to any component of the ointment.

With caution: during pregnancy and breastfeeding.

Use during pregnancy and breastfeeding

Use with caution due to insufficient data confirming the safety of the drug during these periods. If Bactroban is prescribed to treat a cracked nipple, then the nipples must be thoroughly washed before feeding.

Side effects

Very rarely - itching, burning, rawness and dry skin at the site of application; rarely - skin allergic reactions; in isolated cases - systemic allergic reactions; rhinitis (when using intranasal ointment).

Interaction

Directions for use and doses

Intranasally, externally. Intranasal ointment: applied to the inner surface of the nostrils 2-3 times a day for 5-7 days.

Ointment for external use: for adults, children and elderly patients, a small amount is applied to the affected area of ​​the skin 2-3 times a day, if necessary, an aseptic bandage is applied, the course of treatment is up to 10 days.

For liver failure, the standard dosage is used.

Renal failure - see Precautions.

Bactroban ointment should not be combined with other drugs due to the risk of dilution, decreased antibacterial activity and stability.

Overdose

Precautionary measures

2% external ointment cannot be used for the treatment of eye diseases, intranasally, or in the drainage area.

Avoid getting the ointment in your eyes. In case of contact, eyes should be rinsed thoroughly with water until all remaining ointment is completely removed.

Use for renal failure: in elderly patients there are no restrictions for use, except in cases where during treatment conditions arise for the absorption of polyethylene glycol included in the ointment and signs of moderate and severe renal failure. Polyethylene glycol can be absorbed through wounds or other skin lesions and excreted through the kidneys. Dermatological ointment (based on polyethylene glycol) should not be used in conditions accompanied by increased absorption of polyethylene glycol, and especially in cases of moderate or severe renal failure.

In rare cases of allergic reactions or significant irritation of the skin, treatment should be discontinued, the affected area should be rinsed with water to remove any remaining ointment, and alternative anti-infective therapy should be prescribed.

special instructions

After applying to the skin, wash your hands thoroughly. Long-term use of Bactroban ointment can lead to excessive growth of insensitive microorganisms.

No adverse effects on the ability to drive or operate machines were observed.

Storage conditions for the drug Bactroban ®

Keep out of the reach of children.

Shelf life of the drug Bactroban ®

ointment for external use 2% - 2 years.

nasal ointment 2% - 3 years.

nasal ointment 2% - 3 years.

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

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Bactroban nasal ointment: instructions for use

The drug Bactroban is an ointment for local nasal administration. Has a pronounced antimicrobial effect. The active substance that has a therapeutic effect is mupirocin, an antibiotic intended for local therapy that has a wide spectrum of effects. Bactroban has shown high activity in the treatment of diseases caused by Staphylococcus aureus and Staphylococcus epidermidis, Escherichia coli, and Haemophilus influenzae. Mupirocin has no effect on Pseudomonas aeruginosa. If Bactroban is used strictly according to the instructions, then systemic absorption is extremely low. The penetration of mupirocin is enhanced if the ointment is applied to tissue with affected areas.

Release form and composition

Bactroban is available as an ointment for nasal use in aluminum tubes of 3 grams. Recycled cardboard packaging contains 1 tube and detailed instructions. 1 gram of Bactroban nasal ointment contains 20 mg of mupirocin in the form of calcium salt. Additional ingredients include white soft paraffin and softisan 649.

Indications for use

Bactroban should be prescribed for infectious diseases of the nasal cavity caused by mupirocin-sensitive strains of staphylococcus, as well as methicillin-resistant strains.

Contraindications

Restrictions on the use of Bactroban nasal ointment apply to children under 12 years of age and persons with known hypersensitivity to the active ingredient or additional elements.

Directions for use and dosage

Only topical use is recommended during therapy with Bactroban nasal ointment. It is important to thoroughly clean your nose before use. Next, place a small amount of ointment in each nasal passage. After this, short-term pressure is applied to the wings of the nose. You can do a light massage, which will allow the ointment to be better distributed inside the cavities. Do not allow the slightest contact of nasal ointment with your eyes. After use, the tube is carefully closed. Then hand hygiene is carried out with soap and running water. The frequency of use of the ointment is twice a day. The usual course does not exceed 5 days, but if necessary, the doctor may suggest a different therapeutic regimen. If the drug is prescribed to an elderly person or a patient with problems with the kidneys and liver, then dosage adjustment is usually not necessary.

Side effects

Bactroban has proven itself quite well. Sometimes patients may complain of individual allergic manifestations, such as nasal congestion, burning, redness of the skin of the nose, rhinitis, itching. Sometimes a cough, headache, a small rash on the body, and pharyngitis may appear. Taste disturbances rarely develop. Isolated cases of the development of resistance of microorganisms to the drug Bactroban have been recorded. Typically, this complication occurs with a very long course of treatment. For any, even minor, manifestations, you need to consult a doctor who will decide on further therapy with Bactroban.

special instructions

Do not mix the drug with other components, even for nasal administration. Dilution of the ointment leads to a significant decrease in the activity of the active ingredient and can provoke a loss of stability of mupirocin. It is important to avoid contact with eyes. If you have allergic manifestations, you should try to remove the ointment from the nasal passages as much as possible, immediately stop using Bactroban and consult a doctor. It is best to avoid long-term use to reduce the possibility of development of pathogen resistance to mupirocin. When carrying a child, Bactroban is taken only in extreme cases. There is insufficient data to prove safety for the unborn newborn. During lactation, there is currently no evidence that the components of the ointment pass into breast milk. The ointment is approved for the treatment of children from 12 years of age. There is no information about the effect of Bactroban on the health of children under 12 years of age. The drug does not have any effect on the reaction rate, so it can be used in people driving vehicles or other mechanisms that require increased concentration. No cases of overdose have been recorded. If an overdose occurs, symptomatic treatment is recommended.

Analogs

An analogue of Bactroban should include nasal ointment Mupirocin. There is a wide range of nasal medications, the main component of which is an antibiotic, but the composition of such drugs varies significantly.

Terms and conditions of storage

The ointment is stored at temperatures below 25 degrees. Freezing must not be allowed. The shelf life is 3 years. It is recommended to store Bactroban in its original container away from children.

Bactroban ointment nasal price

Bactroban nasal ointment 2%, tube 3 g - from 525 rub.

Source: http://bezboleznej.ru/baktroban-maz-nazalnaya