Antistaphylococcal bacteriophage

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Bacteriophages or phages (from ancient Greek φᾰγω - “I devour”) are viruses that selectively infect bacterial cells. Most often, bacteriophages multiply inside bacteria and cause their lysis.

Table of contents:

As a rule, a bacteriophage consists of a protein shell and genetic material

Bacteriophages are highly effective immunobiological drugs with antibacterial action. Staphylococcal bacteriophage - the drug is intended to combat staphylococcal infections. Instructions for use of the drug Staphylococcal Bacteriophage describe that the bacteriophage is injected into the site of infection.

Staphylococcal bacteriophage is capable of lysing staphylococci, i.e. has the ability to specifically dissolve staphylococcal bacteria isolated during purulent infections.

INSTRUCTIONS for the use of the medicinal product for medical use Staphylococcal bacteriophage

Staphylococcal bacteriophage liquid - instructions for use. Indications for use, composition, pharmacological properties, reviews.

Name of the drug: Staphylococcal bacteriophage.

Dosage form: Solution for oral, local and external use.

Average price for staphylococcal bacteriophage in Russia (2014):

Average price: 880 rub.

Maximum price: 1868 rub.

Compound

Composition of the drug Staphylococcal bacteriophage: 1 ml of the drug contains the active substance of the sterile filtrate of phagolysates of bacteria of the genus Staphylococcus up to 1 ml.

Excipients: Preservative 8-hydroxyquinoline sulfate - 0.0001 g/ml (calculated content); or 8-hydroxyquinoline sulfate monohydrate - 0.0001 g/ml (in terms of 8-hydroxyquinoline sulfate, calculated content).

Description: The drug Staphylococcal Bacteriophage is a transparent yellow liquid of varying intensity.

Pharmacotherapeutic group of the drug: MIBP-bacteriophage.

Biological properties: The drug Staphylococcal Bacteriophage causes specific lysis of Staphylococcus bacteria.

Indications

Indications for use of the drug Staphylococcal Bacteriophage:

  • Treatment and prevention of purulent-inflammatory and enteric diseases caused by bacteria of the genus Staphylococcus in adults and children.
  • diseases of the ear, throat, nose, respiratory tract and lungs (inflammation of the sinuses, middle ear, sore throat, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy);
  • surgical infections (wound suppuration, burns, abscess, phlegmon, boils, carbuncles, hidradenitis, panaritium, paraproctitis, mastitis, bursitis, osteomyelitis);
  • urogenital infections (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis);
  • enteral infections (gastroenterocolitis, cholecystitis), intestinal dysbiosis;
  • generalized septic diseases;
  • purulent-inflammatory diseases of newborns (omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc.);
  • other diseases caused by staphylococci.

In case of severe manifestations of staphylococcal infection, the drug is prescribed as part of complex therapy.

For prophylactic purposes, the drug Staphylococcal Bacteriophage is used for the treatment of postoperative and newly infected wounds, as well as for the prevention of nosocomial infections for epidemic indications.

An important condition for effective phage therapy is the preliminary determination of the sensitivity of the pathogen to the bacteriophage and the early use of the drug Staphylococcal Bacteriophage;

Contraindications to the drug Staphylococcal Bacteriophage:

Individual intolerance or sensitivity to any of the components of the drug.

Use of the drug Staphylococcal Bacteriophage during pregnancy and breastfeeding:

It is advisable to use the drug in the presence of infections caused by phage-sensitive strains of staphylococci (on the recommendation of a doctor).

Method of administration and dosage of the drug Staphylococcal bacteriophage:

The drug is used for oral administration (oral), rectal administration, applications, irrigation, administration into wound cavities, vagina, uterus, nose, sinuses and drained cavities. Before use, the vial with the bacteriophage must be shaken and inspected. The Staphylococcal Bacteriophage preparation should be transparent and not contain sediment.

Recommended dosages of the drug Staphylococcal Bacteriophage:

Dose per 1 dose (ml)

from 1 year to 3 years

from 8 years and older

Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by taking the drug Staphylococcal Bacteriophage orally 2-3 times a day on an empty stomach 1 hour before meals from the first day of the disease for 7-20 days (according to clinical indications).

If chemical antiseptics were used to treat wounds before using the bacteriophage, the wound should be thoroughly washed with a sterile sodium chloride solution of 0.9%.

Depending on the nature of the source of infection, Staphylococcal bacteriophage is used:

1. In the form of irrigation, lotions and tamponing in a volume of up to 200 ml, depending on the size of the affected area. In case of an abscess, after removing the purulent contents using a puncture, the drug Staphylococcal Bacteriophage is administered in an amount less than the volume of the removed pus. In case of osteomyelitis, after appropriate surgical treatment, the bacteriophage is infused into the wound.

2. When administered into cavities (pleural, articular and other limited cavities) up to 100 ml, after which capillary drainage is left, through which the staphylococcal bacteriophage is administered for several days.

3. For cystitis, pyelonephritis, urethritis, the drug is taken orally. If the cavity of the bladder or renal pelvis is drained, staphylococcal bacteriophage is administered through a cystostomy or nephrostomy 1-2 times a day, poured into the bladder and 5-7 ml into the renal pelvis.

4. For purulent-inflammatory gynecological diseases, the drug Staphylococcal Bacteriophage is administered into the cavity of the vagina, uterus in a dose of 5-10 ml once daily, for colpitis - 10 ml by irrigation or tamponing 2 times a day. Tampons are placed for 2 hours.

5. For purulent-inflammatory diseases of the ear, throat, nose, the drug is administered in a dose of 2-10 ml 1-3 times a day. Staphylococcal bacteriophage is used for rinsing, washing, instilling, and introducing moistened turundas (leaving them for 1 hour).

6. For enteral infections and intestinal dysbiosis, the drug is taken orally 3 times a day 1 hour before meals. It is possible to combine double oral administration with a single rectal administration of a single age-specific dose of the bacteriophage in the form of an enema after bowel movement.

Use of Staphylococcal bacteriophage in children (up to 6 months)

For sepsis, enterocolitis of newborns, including premature babies

The bacteriophage is used in the form of high enemas (through a gas outlet tube or catheter) 2-3 times a day in a dose of 5-10 ml. In the absence of vomiting and regurgitation, it is possible to use the drug by mouth. In this case, it is mixed with breast milk. A combination of rectal (in the form of high enemas) and oral (through the mouth) use of the drug is possible. The course of treatment is 5-15 days. In case of recurrent course of the disease, repeated courses of treatment are possible. In order to prevent sepsis and enterocolitis during intrauterine infection or the risk of nosocomial infection in newborns, staphylococcal bacteriophage is used in the form of enemas 2 times a day for 5-7 days.

In the treatment of omphalitis, pyoderma, and infected wounds, the drug Staphylococcal Bacteriophage is used in the form of applications twice daily (a gauze cloth is moistened with the bacteriophage and applied to the umbilical wound or to the affected area of ​​the skin).

Side effects of the drug Staphylococcal bacteriophage

Overdose

Interaction with other drugs.

The use of the drug Staphylococcal Bacteriophage is possible in combination with other drugs, including antibiotics.

Special instructions.

Staphylococcal bacteriophage is not suitable for use in bottles with damaged integrity or labeling, if the expiration date has expired, or if they are cloudy.

Due to the presence of a nutrient medium in the preparation Bacteriophage staphylococcus, in which bacteria from the environment can develop, causing clouding of the preparation, it is necessary to observe the following rules when opening the bottle:

  • wash your hands thoroughly;
  • treat the cap with an alcohol-containing solution; remove the cap without opening the cap;
  • do not place the cork with the inner surface on a table or other objects;
  • do not leave the bottle open
  • Store opened bottle only in the refrigerator

Opening the bottle of Staphylococcal Bacteriophage and extracting the required volume of the drug can be done with a sterile syringe by piercing the stopper. The drug Staphylococcal Bacteriophage from an opened bottle, subject to storage conditions, the above rules and the absence of turbidity, can be used throughout the shelf life.

Impact on the ability to drive vehicles and machinery

Release form of the drug Bacteriophage staphylococcal

Solution for oral, local and external use in bottles of 20 ml or 100 ml. 4 or 8 bottles of 20 ml or 1 bottle of 100 ml in a cardboard pack with instructions for use.

Storage and transportation conditions

Storage in accordance with SP 3.3.2. at a temperature of 2 to 8 ° C in a dry place, protected from light and out of reach of children.

Transportation in accordance with SP 3.3.2. at temperatures from 2 to 8°C, transportation is allowed at temperatures from 9 to 25°C for no more than 1 month.

Shelf life of the drug Bacteriophage staphylococcal.

Shelf life: 2 years. The drug Staphylococcal Bacteriophage with an expired shelf life cannot be used.

Vacation conditions.

Staphylococcal bacteriophage is sold without a prescription.

Source: http://krasgmu.net/publ/zdorove/lekarstva/bakteriofag_stafilokokkovyj_instrukcija_cena_otzyvy/

Bacteriophage Staphylococcal

Description current as of 02/20/2015

  • Latin name: Bacteriophagum Staphylococcum
  • ATX code: J01XX
  • Active ingredient: Staphylococcal bacteriophage (Bacteriophagum staphylococcum)
  • Manufacturer: Biopharma (Ukraine), NPO Microgen (Russia), Biomed (Russia)

Compound

The active component of the drug Staphylococcal Bacteriophage is an anti-staphylococcal bacteriophage in liquid form, in the form of suppositories, ointments or tablets.

Release form

  • 50 or 100 ml of such a solution in a bottle - one bottle in a cardboard box.
  • 20 ml of this solution in a bottle - four bottles in a cardboard box.
  • 25 ml of such a solution in an aerosol package - one package in a cardboard box.
  • 10 and 20 grams of ointment in a bottle, one bottle in a cardboard box.
  • 10 candles per package, one package in a cardboard box.
  • 10, 25 and 50 tablets per package, one package in a cardboard box.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

What is a Bacteriophage?

This drug is relatively new on the drug market and many patients have a natural question: “Bacteriophage - what is it?”

Bacteriophages are viral particles that kill only certain types of pathogenic bacteria. On their basis, appropriate drugs are created. The discovery of the drugs belongs to the Canadian scientist Felix D'Herelle.

Structure of Bacteriophages

An ordinary bacteriophage consists of a tail and a head. The tail is usually 3-4 times longer than the diameter of the head. The head contains double-stranded or single-stranded RNA or DNA with an inactive transcriptase, surrounded by a shell of protein or lipoprotein called the capsid.

Reproduction of Bacteriophages

As with conventional viruses, the reproduction cycle of lytic bacteriophages can be divided into adsorption of the phage on the cell wall, introduction of DNA, reproduction of the phage, and evacuation of daughter populations from the cell.

Attachment of the phage to the bacterial cell occurs due to its surface structures, which serve as specific receptors for viruses. In addition to receptors, phage attachment depends on temperature, acidity of the environment, the presence of cations and a number of other compounds. Up to 300 virus particles can be adsorbed on one cell.

After attachment, the cell wall is broken down by lysozyme enzymes. At the same time, calcium ions are released, activating ATPase - this causes contraction of the sheath and insertion of the tail shaft into the cell. The viral DNA is then injected into the cytoplasm. Having penetrated the bacterium, the phage DNA takes control of the cell’s genetic apparatus, carrying out the phage’s reproductive cycle.

First of all, the synthesis of enzymes necessary for the formation of copies of phage DNA (DNA polymerase, thymidylate synthetase, kinase) occurs. It takes 5-7 minutes from the moment of infection. The cell's RNA polymerase converts viral DNA into mitochondrial RNA, which is translated by ribosomes into early proteins. “Early” proteins are mainly viral RNA polymerase and proteins that limit the expression of bacterial genes. The viral RNA polymerase transcribes the so-called “late” proteins necessary for the assembly of new phage particles.

The reproduction of nucleic acids occurs due to the activity of synthesized DNA polymerases of the virus. By the end of the cycle, the components of the phage are combined into a mature virion.

Evacuation of Bacteriophage populations from the cell

Newly biosynthesized proteins in the cytoplasm form a pool of precursors. The other pool includes the DNA of the offspring. Specialized regions in the viral DNA induce the association of these proteins around groups of nucleic acid molecules and the synthesis of new heads. The head interacts with the tail to form a daughter phage. After the offspring are released, the host cell is destroyed, releasing a new population.

An alternative to cell destruction may be an integrative form of interaction in which the phage DNA, instead of replication, is integrated into the bacterial chromosome or becomes a plasmid. As a result, the viral genome replicates along with the host DNA.

Types of Bacteriophages

The use of bacteriophages determines their clinical classification. Based on this thesis, the following types of bacteriophages can be distinguished:

  • bacteriophages for the treatment of intestinal infections: dysentery, polyvalent, salmonella ABCDE-group, typhoid, coliproteus, intesti-bacteriophage (a mixture of phages against the most common pathogens of intestinal infections);
  • bacteriophages for the treatment of purulent-septic lesions: Klebsiella pneumoniae, Klebsiella polyvalent, Pseudomonas aeruginosa, antistaphylococcal bacteriophage, coli, Proteus, streptococcal, combined pyobacteriophage (a mixture of phages that destroy most likely pathogens of infections of a purulent-septic nature).

The use of bacteriophage preparations in medicine is becoming increasingly widespread due to the increasing incidence of polyvalent resistance of pathogens to antibacterial agents.

Indications for use

How to take this medicine? The drug is used for the treatment and prevention of diseases caused by staphylococcus:

Contraindications

There are no contraindications to the use of this product.

Side effects

Adverse reactions to the administration of the drug have not been established.

With the intradermal route of administration, short-term hyperemia and inflammation are possible.

Instructions for staphylococcal bacteriophage (Method and dosage)

The drug is injected into the site of infection. The frequency of injections and their size are determined by determining the clinical form of the disease, the nature of the infectious focus and standard recommendations. The average duration of treatment is 5-15 days. In cases of relapse, additional courses of treatment are possible. Instructions for using staphylococcal bacteriophage for children and adults are somewhat different. Recommendations for the use of the drug for children are given at the end of the section.

Liquid phage is allowed to be used topically in the form of lotions, irrigation or tamponing in a volume of up to 200 ml, taking into account the size of the affected area. An ointment is also available for topical use.

It is advisable to carry out therapy of purulent-inflammatory limited lesions both locally and orally for 1-4 weeks.

For purulent-inflammatory lesions of the throat, ear or nose, the drug is used for rinsing, instilling, washing and administering moistened turundas 2-10 ml up to three times a day.

For carbuncles and boils, liquid bacteriophage is injected directly into or around the lesion, 0.5-2 ml daily. In total, up to 5 injections are given per course of treatment.

Treatment of chronic osteomyelitis is carried out by infusion of the drug into the wound immediately after surgical treatment.

In case of abscesses, the bacteriophage is injected into the cavity of the lesion, emptied of pus. When opening an abscess, a tampon moistened with the drug is inserted into the wound.

Treatment of deep pyodermatitis is carried out by making intradermal injections of the drug into one place of 0.1-0.5 ml or into several places in a total dose of up to 2 ml. Administration is carried out every 24 hours, a total of 10 injections.

For administration into the abdominal, pleural, and articular cavities, capillary drainage is used, and up to 100 ml of bacteriophage is injected every other day. There are only 3-4 such introductions.

For cystitis, the drug is injected into the bladder using a catheter.

For purulent bursitis, pleurisy or arthritis, the drug is administered into a cavity previously emptied of pus, 20 ml every other day. The course of treatment is 3-4 administrations.

Also, Staphylococcal bacteriophage is used orally in the form of tablets in the treatment of urogenital infections (cystitis, pyelonephritis, pyelitis, salpingoophoritis, endometritis), intestinal infections and other diseases caused by staphylococcus.

How to use Staphylococcal Bacteriophage for intestinal staphylococcal lesions and intestinal dysbiosis: the drug is used orally on an empty stomach three times a day, 2 hours before meals; The drug is prescribed rectally in the form of suppositories or enemas once a day. Treatment lasts 7-10 days.

For newborn children, the drug is diluted with an equal amount of water in the first 2 doses. It can also be mixed with breast milk.

For sepsis or enterocolitis in newborns, the drug is used by performing high enemas up to three times a day. A combination of rectal and oral use is permitted.

When treating pyoderma, omphalitis, purulent wounds in newborns, the drug is used in the form of applications twice a day and in the form of tablets - 1 piece up to four times a day. The ointment is used locally with bandages of 5-20 grams up to two times a day.

For the prevention of enterocolitis and sepsis in newborns, when there is a risk of developing a hospital infection or intrauterine infection, the drug is used in the form of enemas twice a day for a week.

In aerosol form, Staphylococcal Bacteriophage is used to irrigate affected mucous membranes and skin for purulent-inflammatory lesions, burns, septic wounds and sore throat.

The most justified use of this remedy is in cases of infection with antibiotic-resistant strains.

Overdose

Such cases have not been studied.

Interaction

If antiseptic solutions (not including furatsilin) ​​were used before local application of the product, the affected area should be washed with saline solution or 3% sodium bicarbonate solution.

Terms of sale

Dispensing of the drug is permitted without a prescription.

Storage conditions

Store at a temperature of 2-10 degrees in a dark place. Keep away from children.

Best before date

special instructions

Treatment with the drug should be started as early as possible.

The drug must be shaken before use; a cloudy solution should not be used.

When opening the bottle, storing and sampling the product, the following rules should be observed:

  • hands must be washed thoroughly;
  • Before removing, the cap must be treated with an alcohol solution;
  • the cap should be removed without removing the stopper;
  • the drug should be removed from an opened bottle only by piercing the stopper with a sterile syringe;
  • If, during opening, the cork was accidentally uncorked along with the cap, then it should not be placed with the inner surface on the table, and the bottle should not be left open (after taking the product, it must be closed with the cork);
  • It is recommended to store the opened bottle in the refrigerator.

Subject to compliance with the specified rules and in the absence of turbidity, the product from the opened bottle can be used throughout the entire shelf life.

Analogs

For children

The drug is approved for use in newborns and children of all ages.

With antibiotics

During pregnancy and lactation

It is possible to use the product during the specified periods under the supervision of the attending physician.

Reviews of Staphylococcal Bacteriophage

Despite many cases of cure, the therapeutic effect of taking the drug is not guaranteed in all cases. This is evidenced by reviews of Staphylococcal Bacteriophage. This feature is more often detected when the product is used for newborns and young children.

The effectiveness of the drug may vary depending on the sensitivity of the particular strain to the phage and other factors that should be determined before starting treatment.

In some situations, parents prematurely stop the course of treatment for their infant, frightened by the supposedly worsening symptoms of the disease, and then report that the drug did not work on the child. In any case, before deciding to undergo therapy with this medicine, and during treatment, you should be observed by your doctor and clarify all unclear questions with him.

Staphylococcal Bacteriophage price, where to buy

In Ukraine, the price of the drug Staphylococcal Bacteriophage liquid 100 ml produced by the Biopharma company (Kiev) averages 318 hryvnia.

In Russia, the price of staphylococcal and polyvalent Pyobacteriophage liquid bacteriophage in standard packaging of 20 ml No. 4 is almost the same and amounts to rubles.

Buying a staphylococcal bacteriophage in Moscow (manufactured by NPO Microgen, Nizhny Novgorod) will cost rubles per 100 ml bottle.

Such drugs are almost never found in tablet or suppository forms in pharmacies.

  • Online pharmacies in Russia Russia

WER.RU

ZdravZone

Pharmacy IFC

Education: Graduated from Vitebsk State Medical University with a degree in Surgery. At the university he headed the Council of the Student Scientific Society. Advanced training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".

Work experience: Worked in a general medical network for 3 years as a surgeon (Vitebsk Emergency Hospital, Liozno Central District Hospital) and part-time as a district oncologist and traumatologist. Worked as a pharmaceutical representative for a year at the Rubicon company.

Presented 3 rationalization proposals on the topic “Optimization of antibiotic therapy depending on the species composition of microflora”, 2 works took prizes in the republican competition-review of student scientific works (categories 1 and 3).

Ivan: We’ve been working for more than half a year. They have proven themselves. Everything is guaranteed. In stock.

Yulia: I have the same symptoms, I thought it was meningitis. I almost didn’t say goodbye at all. Head.

Diets.Guru: If the stage of the disease and the patient’s condition allow the possibility of surgery.

Kostya: Yesterday I picked up the child from kindergarten, came home and then it all started! At first the boy complained.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/bakteriofag-stafilokokkovyiy

Staphylococcal bacteriophage

Staphylococcal bacteriophage: instructions for use and reviews

Latin name: Bacteriophagum Staphylococcum

Active ingredient: Staphylococcal bacteriophage (Bacteriophagum staphylococcum)

Manufacturer: Biopharma (Ukraine), NPO Microgen (Russia), Biomed (Russia)

Update of description and photo: 11/15/2017

Prices in pharmacies: from 663 rubles.

Staphylococcal bacteriophage is a medical immunobiological preparation for the treatment of diseases caused by staphylococci.

Release form and composition

Dosage form – solution for oral, local and external use: transparent yellow liquid of varying intensity (20 ml bottles, 4 or 8 bottles in a cardboard box; 100 ml bottles, 1 bottle in a cardboard box).

1 ml of solution contains:

  • active substance: sterile filtrate of phagolysates of bacteria of the genus Staphylococcus – up to 1 ml;
  • additional component: preservative 8-hydroxyquinoline sulfate or 8-hydroxyquinoline sulfate monohydrate.

Pharmacological properties

Staphylococcal bacteriophage is a drug that has a specific bactericidal effect against staphylococci - strains that are most significant in the etiology of the development of inflammatory and purulent diseases.

The drug causes specific lysis (dissolution) of bacteria of the genus Staphylococcus. The mechanism of its action is due to the ability of phage particles to attach to the membrane of sensitive bacteria, penetrate into cells and multiply at the expense of their resources, as a result of which these cells die and mature phage particles are released, which can infect other sensitive bacterial cells.

Staphylococcal bacteriophage does not affect other bacteria and does not disrupt the natural microflora.

Indications for use

Staphylococcal bacteriophage is intended for the treatment and prevention of purulent-inflammatory and enteral diseases caused by Staphylococcus bacteria. Particularly applicable in the following cases:

  • generalized septic diseases;
  • surgical infections: abscess, boils, carbuncles, felons, hidradenitis, phlegmon, burns, wound suppuration, bursitis, paraproctitis, osteomyelitis, mastitis;
  • intestinal dysbiosis;
  • enteral infections (gastroenterocolitis, cholecystitis);
  • diseases of the ENT organs, respiratory tract and lungs: tonsillitis, laryngitis, pharyngitis, inflammation of the middle ear and sinuses, tracheitis, pleurisy, bronchitis, pneumonia;
  • urogenital infections: colpitis, salpingoophoritis, endometritis, cystitis, urethritis, pyelonephritis;
  • purulent-inflammatory diseases of newborns, including sepsis, gastroenterocolitis, pyoderma, omphalitis, conjunctivitis;
  • other diseases caused by staphylococci.

For preventive purposes, staphylococcal bacteriophage is also used to treat wounds (postoperative and newly infected).

According to epidemic indications, it is prescribed for the prevention of nosocomial infections.

Contraindications

According to the instructions, Staphylococcal Bacteriophage is contraindicated in cases of hypersensitivity or intolerance to the components of the drug.

Instructions for use of Staphylococcal Bacteriophage: method and dosage

The solution is used orally, rectally, in the form of applications and irrigations, for administration into the cavities and sinuses of the nose, into the cavities of the vagina and uterus, as well as into drained cavities.

Before use, the bottle should be shaken and inspected for any cloudiness or sediment.

Recommended single doses for oral administration of Staphylococcal Bacteriophage depending on age:

  • 0–6 months – 5 ml;
  • 6–12 months – 10 ml;
  • 1–3 years – 15 ml;
  • 3–8 years – 15–20 ml;
  • from 8 years and older – 20–30 ml.

Recommended single doses for rectal use of Staphylococcal Bacteriophage depending on age:

  • 0–6 months – 5–10 ml;
  • 6–12 months – 10–20 ml;
  • 1–3 years – 20–30 ml;
  • 3–8 years – 30–40 ml;
  • from 8 years and older – 40–50 ml.

For intestinal dysbiosis and enteral infections, the solution is taken orally 3 times a day, an hour before meals. It is also possible to use the following treatment regimen: 2 times a day oral administration and 1 time per day rectal administration of a single dose appropriate for age, in the form of an enema after bowel movement.

For the treatment of urethritis, cystitis and pyelonephritis, the bacteriophage is prescribed orally. If the cavity of the renal pelvis or bladder is drained, the drug is administered through a nephrostomy or cystostomy 1-2 times a day, 5-7 ml into the renal pelvis or 20-50 ml into the bladder.

For purulent-inflammatory diseases with localized lesions, the drug is prescribed both locally and orally: 2-3 times a day 1 hour before meals for 7-20 days (depending on the clinical situation).

Methods of using Staphylococcal Bacteriophage depending on the nature of the source of infection:

  • in the form of tamponing, lotions and irrigation in a volume of up to 200 ml (depending on the size of the affected area). For osteomyelitis, after surgical treatment, the solution is poured into the wound in an amount of 10–20 ml. In case of an abscess, after removal of purulent exudate, the drug is administered by puncture in a volume less than the amount of removed contents;
  • in the form of instillation, washing, rinsing, introducing moistened turundas. For purulent-inflammatory diseases of the ENT organs, the drug is administered 2–10 ml 1–3 times a day. Turundas soaked in the solution are administered for 1 hour;
  • injection into cavities (articular, pleural and other organic cavities) in a volume of up to 100 ml. Subsequently, capillary drainage is left, through which the bacteriophage is introduced for several more days;
  • insertion into the cavity of the vagina and uterus. For purulent-inflammatory diseases, the drug is administered 5–10 ml once a day; for colpitis, it is used in the form of tampons 2 times a day for 2 hours or 10 ml in the form of irrigation.

In cases where chemical antiseptics were used to treat wounds before prescribing the bacteriophage, the wounds must be thoroughly washed with a sterile solution of sodium chloride 0.9%.

Use of bacteriophage in children under 6 months

For enterocolitis and sepsis in newborns, including premature infants, Staphylococcal bacteriophage is used in the form of high enemas (through a catheter or gas outlet tube) of 5–10 ml 2–3 times a day. If the child is not vomiting or regurgitating, the bacteriophage can be given orally, mixed with breast milk. A combination of oral and rectal administration is possible. The duration of therapy is from 5 to 15 days. In case of recurrent course of the disease, repeat courses are carried out.

To prevent enterocolitis and sepsis in cases of intrauterine infection or the risk of developing a nosocomial infection, the drug is used in the form of enemas 2 times a day for a course of 5–7 days.

For infected wounds, pyoderma and omphalitis, the staphylococcal bacteriophage is used in the form of applications: a gauze cloth moistened with a solution is applied to the affected area of ​​the skin or the umbilical wound 2 times a day.

Side effects

The drug does not cause side effects.

Overdose

There were no cases of overdose.

special instructions

An important condition for effective phage therapy is determining the sensitivity of the pathogen to the bacteriophage and prescribing the drug as early as possible after the appearance of purulent-inflammatory signs.

In case of severe manifestations of infection, staphylococcal bacteriophage is used as part of complex therapy.

The drug contains a nutrient medium in which bacteria from the environment can develop, causing the solution to become cloudy. In this regard, the following rules of use and storage must be observed:

  • wash your hands thoroughly;
  • treat the cap with an alcohol-containing product;
  • do not place the cork on the table or other objects with the inner surface;
  • do not leave the bottle open;
  • After opening the bottle for the first time, store the drug only in the refrigerator.

After opening the bottle, provided that the listed rules are followed and there is no cloudiness, the drug can be used throughout the expiration date.

The required amount of solution should be removed from the bottle using a sterile syringe by piercing the stopper.

It is prohibited to use Staphylococcal Bacteriophage if the shelf life of the drug has expired, the solution has become cloudy, or the labeling or integrity of the bottle has been damaged.

Impact on the ability to drive vehicles and complex mechanisms

Use during pregnancy and lactation

Staphylococcal bacteriophage can be used as prescribed by a doctor during pregnancy and lactation in the presence of infections caused by phage-sensitive strains of staphylococci.

Use in childhood

There are no age restrictions for the use of the drug.

Drug interactions

Can be used in combination with other drugs, including antibiotics.

Analogs

There is no information on analogues of Staphylococcal Bacteriophage.

Terms and conditions of storage

Store and transport in accordance with Sanitary and Epidemiological Rules 3.3.2. in a place protected from light at a temperature of 2–8 °C. Transportation is allowed in temperature conditions of 9–25 °C, but not more than 1 month. Keep away from children.

Shelf life – 2 years.

Conditions for dispensing from pharmacies

Available without a prescription.

Reviews of Staphylococcal Bacteriophage

Reviews about Staphylococcal Bacteriophage are mostly positive. Patients confirm the high effectiveness of the drug in the fight against diseases caused by staphylococci, and consider it a worthy and safer alternative to antibiotics.

However, there are also individual reviews that indicate that the bacteriophage was ineffective and even caused side effects (diarrhea, increased body temperature), although the instructions indicate that the drug was very well tolerated and there were no unwanted reactions.

The disadvantages of almost all patients include the high cost of Staphylococcal Bacteriophage and its unpleasant taste, as well as the inconvenience of storage (in the refrigerator) and use (the need to draw the solution with a sterile syringe to maintain asepsis).

Price for Staphylococcal Bacteriophage in pharmacies

Prices for Staphylococcal Bacteriophage are 630–795 rubles for a package of 4 bottles of 20 ml, 710–1165 rubles for 1 bottle of 100 ml.

Bacteriophage staphylococcal solution 20 ml 4 pcs.

Bacteriophage staphylococcal liquid 20ml No. 4 bottles

Bacteriophage staphylococcal solution 100 ml

Staphylococcal bacteriophage 20ml N4

Staphylococcal bacteriophage 100ml

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Source: http://www.neboleem.net/bakteriofag-stafilokokkovyj.php

Staphylococcal bacteriophage

Indications for use

Treatment and prevention of purulent-inflammatory and enteral diseases caused by bacteria of the genus Staphylococcus in adults and children.

  • diseases of the ear, throat, nose, respiratory tract and lungs (inflammation of the sinuses, middle ear, sore throat, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy);
  • surgical infections (wound suppuration, burns, abscess, phlegmon, boils, carbuncles, hidradenitis, panaritium, paraproctitis, mastitis, bursitis, osteomyelitis);
  • urogenital infections (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis);
  • enteral infections (gastroenterocolitis, cholecystitis), intestinal dysbiosis;
  • generalized septic diseases;
  • purulent-inflammatory diseases of newborns (omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc.);
  • other diseases caused by staphylococci.

In case of severe manifestations of staphylococcal infection, the bacteriophage is prescribed as part of complex therapy.

For prophylactic purposes, the drug is used for the treatment of postoperative and newly infected wounds, as well as for the prevention of nosocomial infections for epidemic indications.

An important condition for effective phage therapy is the preliminary determination of the sensitivity of the pathogen to the bacteriophage and the early use of the drug.

Contraindications

Individual intolerance or sensitivity to any of the components of the drug.

Use during pregnancy and breastfeeding

It is advisable to use the drug in the presence of infections caused by phage-sensitive strains of staphylococci (on the recommendation of a doctor).

Directions for use and doses

The drug is used for oral administration (oral), rectal administration, applications, irrigation, administration into wound cavities, vagina, uterus, nose, sinuses and drained cavities. Before use, the vial with the bacteriophage must be shaken and inspected. The preparation must be transparent and free of sediment.

Dose per 1 dose (ml)

from 1 year to 3 years

from 8 years and older

Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by taking the drug orally for 7–20 days (according to clinical indications).

If chemical antiseptics were used to treat wounds before using the bacteriophage, the wound should be thoroughly washed with a sterile 0.9% sodium chloride solution.

Depending on the source of infection, the bacteriophage is used:

  1. In the form of irrigation, lotions and tamponing in a volume of up to 200 ml, depending on the size of the affected area. In case of an abscess, after removing the purulent contents using a puncture, the drug is administered in an amount less than the volume of the removed pus. In case of osteomyelitis, after appropriate surgical treatment, 10–20 ml of bacteriophage is poured into the wound.
  2. When administered into cavities (pleural, articular and other limited cavities), up to 100 ml, after which capillary drainage is left, through which the bacteriophage is administered for several days.
  3. For cystitis, pyelonephritis, urethritis, the drug is taken orally. If the cavity of the bladder or renal pelvis is drained, the bacteriophage is injected through the cystostomy or nephrostomy 1–2 times a day, poured into the bladder and 5–7 ml into the renal pelvis.
  4. For purulent-inflammatory gynecological diseases, the drug is administered into the cavity of the vagina, uterus in a dose of 5-10 ml once daily, for colpitis - 10 ml by irrigation or tamponing 2 times a day. Tampons are placed for 2 hours.
  5. For purulent-inflammatory diseases of the ear, throat, and nose, the drug is administered in a dose of 2–10 ml 1–3 times a day. The bacteriophage is used for rinsing, washing, instillation, and introducing moistened turundas (leaving them for 1 hour).
  6. For enteral infections and intestinal dysbiosis, the drug is taken orally 3 times a day 1 hour before meals. It is possible to combine double oral administration with a single rectal administration of a single age-specific dose of the bacteriophage in the form of an enema after bowel movement.

Use of bacteriophage in children (up to 6 months)

For sepsis and enterocolitis in newborns, including premature babies, the bacteriophage is used in the form of high enemas (through a gas tube or catheter) 2-3 times a day in a dose of 5-10 ml. In the absence of vomiting and regurgitation, it is possible to use the drug by mouth. In this case, it is mixed with breast milk. A combination of rectal (in the form of high enemas) and oral (through the mouth) use of the drug is possible. The course of treatment is 5–15 days. In case of recurrent course of the disease, repeated courses of treatment are possible. In order to prevent sepsis and enterocolitis during intrauterine infection or the risk of nosocomial infection in newborns, the bacteriophage is used in the form of enemas 2 times a day for 5–7 days.

In the treatment of omphalitis, pyoderma, and infected wounds, the drug is used in the form of applications twice daily (a gauze pad is moistened with a bacteriophage and applied to the umbilical wound or affected area of ​​skin).

Side effect

Price and where to buy staphylococcal bacteriophage?

BACTERIOPHAGE IS A SAFE ALTERNATIVE TO ANTIBIOTICS.

Source: http://www.bacteriofag.ru/products/bakteriofag-stafilokokkovyy-20-ml/

Instructions for use of staphylococcal Bacteriophage for children and adults

After studying the instructions for use, you will learn how to use staphylococcal Bacteriophage for Staphylococcus aureus in an adult or child, as well as its price, indications and side effects. The medicine is an immunobiological preparation, the composition of which is based on specific viruses. They infect microorganisms that are sensitive to them. This remedy is used only in the presence of an infection caused by bacteria of the genus Staphylococcus (staphylococcus). The medicine is new, but has already proven itself to be an effective drug with good reviews.

What is staphylococcal bacteriophage

This is the name for a biological product containing beneficial viruses that have a detrimental effect on pathogenic bacterial cells. The peculiarity of the product is that it is effective only against one pathogen. This distinguishes them from antibiotics. Staphylococcal bacteriophage lives from a strain of staphylococci, which are the causative agent of purulent diseases. The drug is often prescribed to treat infections of the skin and mucous membranes of the visceral organs.

Compound

The active ingredient of the drug is anti-staphylococcal bacteriophage. This is a viral particle that kills pathogens. It consists of a head and a tail, which is 3-4 times its diameter. The main substance can be presented in liquid form, in the form of tablets, ointments or suppositories. An additional component is quinosol.

pharmachologic effect

Staphylococcal bacteriophage has antibacterial activity against staphylococcal cells. Viral particles attack pathogenic microorganisms and release their DNA and RNA inside due to the preliminary dissolution of the shell. The main substance practically does not penetrate into the systemic circulation. It is localized only at the site of inflammation, because it exists only under the condition of a staphylococcal infection. After the destruction of pathogenic viruses, the number of bacteriophage particles gradually decreases, and then it is eliminated from the body tissues.

Release form

The main form of release is a solution. It is packaged in 50 or 100 ml bottles in one box and 20 ml bottles in sets of 4, as shown in the photo. Other forms of release of the drug:

  • tablets of 10, 25 or 50 pieces, packaged in cardboard packages;
  • aerosol with a volume of 25 ml;
  • ointment in bottles of 10 or 20 g;
  • rectal suppositories, packed in 10 pieces.

Indications for use

Staphylococcal bacteriophage is used for all acute and chronic diseases caused by staphylococcus. This drug is indicated for the treatment of intestinal dysbiosis, cholecystitis, gastroenterocolitis. These are diseases of the digestive tract. In addition to intestinal infections, many other pathologies or cases are also indicated for use:

  • surgical infections - boils, felons, abscesses, arthritis, bursitis, osteomyelitis, burns, purulent wounds, mastitis, hidradenitis, carbuncles;
  • diseases of the ENT organs - inflammation of the sinuses or middle ear, runny nose, sinusitis, sore throat, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy;
  • urogenital infections – urethritis, colpitis, cystitis, endometritis, pyelonephritis;
  • prevention of nosocomial infections and prevention of sepsis after surgery.

Advantages of staphylococcal bacteriophage over antibiotics

The bacteriophage has an antibacterial effect. Antibiotic drugs also have it. Medicines differ from each other in several ways. Judging by the reviews, the bacteriophage has undeniable advantages that allow you to make a choice in favor of it rather than antibiotics. These advantages are the following:

  • does not suppress human immunity;
  • does not lead to the development of phage-resistant cultures;
  • do not destroy beneficial bacterial microflora;
  • do not lead to addiction;
  • have no contraindications;
  • effective against microorganisms that are insensitive to antibiotics;
  • can be used with all other medications, including antibiotics;
  • can be prescribed for the purpose of prevention;
  • allowed for people of any age, even infants;
  • not prohibited for pregnant and lactating women;
  • has an immunomodulatory effect.

Instructions for use of Staphylococcal Bacteriophage

Before prescribing, the sensitivity of the pathogen to the bacteriophage is checked. The drug itself is injected into the lesion after removal of the purulent contents. The dose and frequency of use are determined taking into account the disease and age of the patient. The average duration of treatment is 5-15 days. Additional therapy is prescribed for relapses. Depending on the form of release, the medicine is used orally, rectally, in the form of injections, irrigations or applications. The bacteriophage is injected into the uterus or vagina, nasal sinuses or drainage cavities.

Liquid Bacteriophage

This form of Bacteriophage release is used topically for irrigation, tamponing or lotions. Taking into account the nature of the purulent focus of infection, the doctor determines the treatment regimen:

  1. For purulent-inflammatory diseases of the ENT organs, 2-10 ml is indicated up to 3 times a day. The medicine can be administered using turundas into the nasal passages for 1 hour. The same dosage is used for rinsing, rinsing and inhaling the throat.
  2. For pyelonephritis, urethritis, cystitis, the solution is administered through a cytostomy or nephrostomy up to 2 times a day. Dosage for the bladder cavity – ml, for the renal pelvis – 5-7 ml.
  3. For purulent infections of the uterus or vagina. In this case, it is indicated to take the liquid form of the drug orally, 5-10 ml once a day. To treat colpitis, a tampon is inserted into the vagina for 2 hours, which is generously moistened with bacteriophage, or irrigated with 10 ml of solution.
  4. To treat boils, liquid bacteriophage is injected directly into or around the site of inflammation, 0.5-2 ml. The course of treatment is 2-3 administrations.
  5. In case of chronic osteomyelitis, after surgical treatment, liquid staphylococcal bacteriophage is poured into the wound in a quantity of ml.
  6. For administration into the joint cavities, a dosage of up to 100 ml is used. Then, for several more days, the bacteriophage is reintroduced through capillary drainage.

In tablets

Staphylococcal bacteriophage in tablets is used less frequently, because the bioavailability of this form of release is significantly lower compared to the solution. When treating urogenital infections caused by staphylococcus, 3 tablets are prescribed daily an hour before meals. Dosage regimens for other diseases:

  1. For the treatment of purulent-inflammatory diseases with localized lesions, tablets are taken orally 2-3 times a day 1 hour before meals. The course of treatment is 7-20 days, taking into account the clinical situation.
  2. For dysbacteriosis. Tablets are taken daily 1-3 times an hour before meals. To increase the effectiveness of treatment for dysbiosis, a combination of rectal administration in the form of enemas after bowel movements is recommended.

Instructions for use for children

For a newborn baby, the drug is diluted with water in a 1:1 ratio. This condition is met in the first two applications. It is allowed to mix the solution with breast milk. For other diseases, the child’s treatment regimen is as follows:

  1. Pyoderma, purulent inflammation, omphalitis. Newborns are advised to apply twice a day to the affected surface. To do this, 5-20 g of ointment is applied to gauze or bandage and applied to the desired location. Additionally, 1 tablet can be prescribed up to 4 times a day.
  2. Ear inflammation. You need to drip 2-3 drops of the solution into each ear canal. For children under 3 years old, cotton wool moistened with the drug is inserted into the ears.
  3. Enterocolitis, sepsis in newborns. Treatment is high enemas 2-3 times a day with a dosage of 5-10 ml of solution. The course of treatment is 5-15 days.

How to gargle

Do not mix the bacteriophage solution with other liquids. It is correct to gargle with undiluted medication. To prevent staphylococcus from getting inside, you need to pierce the plug with a disposable sterile syringe. Next, the needle is removed from it, after which they immediately begin gargling or instilling nose drops. It is not recommended to pour the solution into non-sterile containers.

Bacteriophage during pregnancy and lactation

The absence of serious contraindications and side effects made it possible to use Antistaphylococcal Bacteriophage in the treatment of infections in pregnant women. An important condition is that therapy should be prescribed only by a doctor and carried out under his supervision. In addition, this type of bacteriophage is also prescribed only if the expectant mother has an infection caused by staphylococci.

Drug interactions

Staphylococcal bacteriophage can be used together with other drugs, including antibiotics. If the drug is used locally after using antiseptic solutions, excluding Furacilin, then it is recommended to first rinse the affected area with a 3% solution of sodium bicarbonate or saline.

Side effects and overdose

During the study of the drug, no side effects from its use were identified. Judging by the reviews, they are observed only with intradermal administration. Inflammation and hyperemia may occur here, but they are short-lived. Symptoms in case of an overdose of Bacteriophage have also not been studied, therefore they are also not described in the instructions for use of the drug.

Contraindications

Staphylococcal bacteriophage is distinguished by the fact that it has no serious contraindications. The only case when it cannot be used is individual intolerance or hypersensitivity to the active components of the drug. The medicine is allowed even for children and pregnant women, but subject to the exact dosage and dosage regimen.

Analogs

The staphylococcal bacteriophage has a number of drugs that are similar to it in the principle of action, i.e. also having an antibacterial effect against certain pathogenic microorganisms. Such means include:

The cost of the drug will vary slightly depending on the place of purchase. You can buy the drug in a regular or online pharmacy with home delivery. Bacteriophage is approved for sale without a doctor's prescription. Specific prices for the medicine are presented in the table:

Liquid No. 4, bottles

Solution for oral and external use

Liquid No. 4, bottles

Solution for oral and external use

Solution for oral and external use

Liquid No. 4, bottles

Solution for oral and external use

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Video

The information presented in the article is for informational purposes only. The materials in the article do not encourage self-treatment. Only a qualified doctor can make a diagnosis and make recommendations for treatment based on the individual characteristics of a particular patient.

Source: http://sovets.net/13271-stafilokokkovyj-bakteriofag.html