Antigrippin Anvi instructions for use reviews

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Antigrippin-ANVI

Description current as of 01/27/2015

  • Latin name: Antigrippin-ANVI
  • ATX code: R05X
  • Active ingredient: Diphenhydramine hydrochloride (Hydrochloride diphenhydramine), Calcium gluconate (Gluconas calcii), Metamizole sodium (Metamizolum natrium), Rutoside (Rutosidum), Acidum acetylsalicylicum & ascorbinicum
  • Manufacturer: AnviLab (Russia)

Compound

  • Composition of one capsule A of the drug Antigrippin-ANVI: 300 mg of ascorbic acid, 250 mg of acetylsalicylic acid, 20 mg of rutoside (in the form of trihydrate). Additional substances: calcium stearate, potato starch. Ingredients of gelatin capsules: yellow quinoline dye, black diamond dye, azorubine dye, proprietary blue or blue brilliant dye, gelatin, titanium dioxide.
  • One capsule B contains: 20 mg of diphenhydramine hydrochloride, 250 mg of metamizole sodium monohydrate, 100 mg of calcium gluconate monohydrate. Additional substances: calcium stearate, potato starch. Ingredients of gelatin capsules: titanium dioxide, gelatin.

Table of contents:

Release form

The drug Antigrippin-ANVI includes capsules of two types:

  • capsules A are usually green, hard; contents - a mixture of amorphous and crystalline mass of light yellow color with a slight green tint, the presence of lumps is possible;
  • capsules B are usually white and also hard; contents - a mixture of small granules and white powder, the presence of a yellow tint or lumps is allowed.

Ten capsules A in a contour package and ten capsules B in a contour package; one package of each capsule in a paper pack.

pharmachologic effect

Antipyretic, analgesic, angioprotective, antihistamine, anti-inflammatory effect.

Pharmacodynamics and pharmacokinetics

Ascorbic acid regulates redox reactions, carbohydrate metabolism, tissue regeneration processes, blood clotting, and increases the body's resistance.

Acetylsalicylic acid (aspirin) has antipyretic, analgesic, anti-inflammatory, and antiplatelet effects.

Rutoside (or rutin) is a powerful angioprotector. Reduces capillary permeability, symptoms of inflammation, stabilizes the vascular wall. Reduces aggregation and increases deformation of red blood cells.

Diphenhydramine has antiallergic and anti-edematous effects. Reduces vascular permeability, relieves hyperemia and swelling of the nasal mucosa, manifestations of hypersensitivity reactions in the respiratory tract.

Calcium gluconate regulates the exchange of phosphorus and calcium, has an antiallergic effect, and reduces vascular permeability. In the treatment of allergic diseases, its use in conjunction with antihistamines is recommended.

Indications for use

Contraindications

The drug has the following contraindications for use:

It is recommended to prescribe Antigrippin-ANVI with caution for gout, urate nephrolithiasis, hyperuricemia, peptic ulcer, decompensated cardiac failure.

Side effects

  • Phenomena from the digestive system: gastralgia, anorexia, diarrhea, bleeding, erosive and ulcerative changes, vomiting, nausea, liver failure.
  • Phenomena from the system: increased pressure, tachycardia.
  • Phenomena from the genitourinary system: renal failure.
  • Allergic phenomena: angioedema, rash, bronchospasm.

Side effects observed when using the drug for longer than one week

  • Nervous system effects: headache, dizziness.
  • Phenomena from the organs of hearing and eyes: tinnitus, visual impairment, deafness.
  • Phenomena from the hematopoietic system: thrombocytopenia, leukopenia, agranulocytosis.
  • Respiratory system effects: bronchospasm.
  • Allergic phenomena: possible development of anaphylactic shock, Lyell's syndrome or Stevens-Johnson syndrome.
  • Phenomena from the blood coagulation system: hypocoagulation, weakening of platelet aggregation, hemorrhagic syndrome.
  • Phenomena from the genitourinary system: papillary necrosis of the kidneys, interstitial nephritis, impaired renal function, anuria, oliguria, proteinuria, red staining of urine.
  • Other phenomena: the development of Reye's syndrome is possible in children (metabolic acidosis, hyperpyrexia, vomiting, mental changes, liver damage).

Instructions for Antigrippin-ANVI

Antigrippin-ANVI capsules, instructions for use

Capsules are prescribed orally to persons over 15 years of age, two at a time (one capsule A and one capsule B). Take after meals twice or thrice a day. The treatment period with the drug is usually three to five days.

If there is no effect from taking this medicine, you should stop using it and consult your doctor.

Overdose

Symptoms of overdose: vomiting, nausea, sweating, stomach pain, pale skin, tachycardia; with a slight overdose, ringing in the ears may occur; in case of severe overdose - collapse, drowsiness, convulsions, difficulty breathing, bronchospasm, anuria, progressive respiratory paralysis, bleeding.

Interaction

When used together with indirect anticoagulants, heparin, reserpine, hypoglycemic agents and steroid hormones, their effect is enhanced.

When used simultaneously with Furosemide, Spironolactone, uricosuric and antihypertensive drugs, their effectiveness is reduced.

The drug enhances undesirable reactions of glucocorticosteroids, methotrexate derivatives, sulfonylureas, non-opioid analgesics and non-steroidal anti-inflammatory drugs.

Ascorbic acid enhances the absorption of iron preparations in the intestine.

When used simultaneously with barbiturates, zidovudine, antiepileptic drugs, rifampicin and alcohol-containing drugs, the risk of hepatotoxicity increases.

Metamizole sodium stimulates the effects of alcoholic beverages.

Tricyclic antidepressants, Allopurinol and oral contraceptives alter the metabolism of metamizole and increase its toxicity.

The simultaneous use of Metamizole with Cyclosporine reduces the level of the latter in the blood.

When used together, Thiamazole sodium and Melphalan increase the risk of leukopenia.

X-ray contrast agents, Penicillin and colloidal blood substitutes should not be used while taking Metamizole sodium.

Terms of sale

Storage conditions

Store at temperatures up to 25 degrees in a dry and dark place. Keep away from children.

Best before date

special instructions

With long-term use of the drug, it is necessary to perform an analysis of peripheral blood and indicators of liver condition.

Acetylsalicylic acid in small doses reduces the evacuation of uric acid - this can provoke an exacerbation of gout.

During the period of use of the drug, patients should avoid drinking alcoholic beverages due to the increased risk of bleeding from the digestive system.

Taking ascorbic acid by patients with intensively metastasizing cancer can cause a worsening of the process.

During the period of use of the product, driving should be avoided.

Analogs

For children

The drug is not prescribed to children under 15 years of age with acute viral respiratory diseases as an antipyretic drug due to the risk of Reye's syndrome (acute fatty liver degeneration and encephalopathy with a fulminant form of liver failure).

During pregnancy and lactation

Antigrippin-ANVI is contraindicated during pregnancy.

If there is a need for use during lactation, it is advised to stop feeding while using the product.

Reviews about Antigrippin-ANVI

Reviews about this drug can be assessed as contradictory. Approximately half of the patients recorded a stable therapeutic effect. The rest note either the development of undesirable effects, or the short duration of the therapeutic effect, or its complete absence.

Antigrippin-ANVI price, where to buy

The price of a package of the drug in Russia is rubles.

  • Online pharmacies in Russia Russia

WER.RU

ZdravZone

Pharmacy IFC

Education: Graduated from Vitebsk State Medical University with a degree in Surgery. At the university he headed the Council of the Student Scientific Society. Advanced training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".

Work experience: Worked in a general medical network for 3 years as a surgeon (Vitebsk Emergency Hospital, Liozno Central District Hospital) and part-time as a district oncologist and traumatologist. Worked as a pharmaceutical representative for a year at the Rubicon company.

Presented 3 rationalization proposals on the topic “Optimization of antibiotic therapy depending on the species composition of microflora”, 2 works took prizes in the republican competition-review of student scientific works (categories 1 and 3).

Alexander, antigrippin Anvi is not an antibiotic. This is not even an antiviral drug, but a medication to relieve symptoms of viral infections and colds. Read the composition.

antigrippin Anvi is a very strong antibiotic, an excellent medicine, but 8-10 hours after use, you must definitely drink a cup of kefir, otherwise stomach problems will begin

If I’m sick, everyone at home hangs themselves from me, I can’t stand body aches, and howl from headaches. That’s why I discovered anti-grippin from a natural product that doesn’t put me on bed rest. I advise everyone, be healthy!

Nina V.: The article is useful, you can take note and apply it to yourself

Andrey: Not a word is said about choosing the size of stockings according to a person’s parameters: height, leg size, etc.

Olga: For coxarthrosis of the 2nd degree, I have been injecting for 4 years at the rate (after 6 months), there is no improvement.

Victoria: I don’t put my daughter in a car without taking a Dramamine tablet. We already had it.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/antigrippin-anvi

Antigrippin-Anvi INSTRUCTIONS

Prices for Antigrippin-Anvi

The drug is used for the symptomatic treatment of acute respiratory diseases of various etiologies, including viral and bacterial, in patients over 15 years of age.

The drug is intended for oral use. It is recommended to swallow the capsules whole, without chewing or crushing, with a sufficient amount of water. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient.

Adults and adolescents over the age of 15 years are usually prescribed 2 capsules of the drug (1 white capsule and 1 green capsule) 2-3 times a day. The duration of treatment should not exceed 3 days. If the drug does not have the expected therapeutic effect or the symptoms of the disease persist 3 days after starting the drug, you must contact your doctor, who, after re-diagnosis, will prescribe another drug.

When using the drug, patients experienced the following side effects:

From the gastrointestinal tract: nausea, vomiting, loss of appetite, pain in the epigastric region, erosive and ulcerative lesions of the stomach and duodenum. In patients with a tendency to bleed, gastrointestinal bleeding may develop.

From the liver: hepatitis, liver failure, increased activity of liver enzymes.

From the cardiovascular system: tachycardia, arterial hypertension.

Allergic reactions: skin rash, itching, urticaria, bronchospasm, angioedema.

When using the drug for more than 7 days, patients may develop the following side effects:

From the central and peripheral nervous system: headache, dizziness, fainting, disturbance of sleep and wakefulness, decreased speed of psychomotor reactions, disturbance of orientation in space.

From the gastrointestinal tract: dry mouth, stool disorders.

From the cardiovascular system and hematopoietic organs: increased blood pressure, leukopenia, thrombocytopenia, agranulocytosis, hemorrhagic syndrome, including nosebleeds, bleeding gums and purpura.

From the urinary system: kidney damage, including papillary necrosis, interstitial nephritis, difficulty urinating, anuria, oliguria, proteinuria. In addition, the urine may turn red.

Allergic reactions: urticaria, photosensitivity, contact dermatitis, bronchospasm, Stevens-Johnson syndrome, Lyell's syndrome, anaphylactic shock.

Others: Reye's syndrome in children, non-cardiogenic pulmonary edema.

If side effects develop, you must stop taking the drug and contact your doctor.

Increased individual sensitivity to the components of the drug.

Severe liver and/or kidney dysfunction.

The drug is not used for the treatment of patients suffering from diseases of the gastrointestinal tract such as erosive and ulcerative lesions of the stomach and duodenum during exacerbation and gastrointestinal bleeding.

- hematopoietic disorders, including agranulocytosis, neutropenia and leukopenia;

- hemophilia, telangiectasia, hypoprothrombinemia, thrombocytopenia, von Willebrand disease;

- dissecting aortic aneurysm;

— the drug is not prescribed to patients with a tendency to bleeding and vitamin K deficiency.

The drug is not used to treat patients with glucose-6-phosphate dehydrogenase deficiency, as well as patients with hypercalcemia or hypercalciuria.

Contraindications to the use of the drug Antigrippin-Anvi are also calcium nephrolithiasis, sarcoidosis and glycoside intoxication.

The drug is not used for the treatment of women during pregnancy and lactation, as well as for the treatment of children under the age of 15 years.

The drug is also prescribed with caution to patients with a history of gastric and duodenal ulcers.

The drug is contraindicated for use during pregnancy. Acetylsalicylic acid has a pronounced teratogenic effect. When used in the first trimester of pregnancy, it can lead to fetal malformations, in particular cleft palate. When using the drug in the third trimester of pregnancy, delayed labor and closure of the ductus arteriosus in the fetus may develop. Before using the drug for the treatment of women of childbearing age, it is recommended to exclude pregnancy.

If it is necessary to use the drug during lactation, it is recommended to resolve the issue of interrupting breastfeeding.

When used together, the drug enhances the effect of heparin and oral anticoagulants.

The drug enhances the therapeutic effects of reserpine, hypoglycemic drugs and steroid hormones.

When used simultaneously, the drug reduces the effectiveness of furosemide, spironolactone, antihypotensive drugs and anti-gout drugs. In addition, the drug increases the excretion of uric acid.

When using the drug together with glucocorticosteroids, sulfonylurea derivatives, non-steroidal anti-inflammatory drugs and methotrexate, there is an increased risk of developing side effects of the latter.

The drug is not prescribed to patients receiving therapy with antiepileptic drugs, barbiturates, rifampicin and zidovudine. In addition, the use of radiocontrast agents, penicillin and colloid blood substitutes is contraindicated in patients taking the drug Antigrippin-Anvi.

The drug enhances the absorption of iron in the gastrointestinal tract.

The drug reduces plasma concentrations of cyclosporine when used simultaneously.

With simultaneous use of the drug with thiamazole and sarcolysine, there is an increased risk of developing leukopenia.

Sedatives and tranquilizers enhance the analgesic effect of metamizole sodium.

Oral contraceptives, allopurinol and tricyclic antidepressants increase the toxic effect of the drug Antigrippin-Anvi.

When using excessive doses of the drug, patients experience the development of nausea, vomiting, pain in the epigastric region, increased sweating, tachycardia and pallor of the skin. With a further increase in dose, tinnitus, drowsiness, bronchospasm, decreased blood pressure up to collapse, convulsions, anuria, and bleeding may develop. In addition, the development of respiratory acidosis caused by uncoupling of oxidative phosphorylation and progressive respiratory paralysis is possible.

In case of an overdose of the drug, gastric lavage, enterosorbents and saline laxatives are indicated. In addition, hospitalization and forced diuresis and hemodialysis in a hospital setting are indicated. If a patient develops a convulsive syndrome, intravenous administration of barbiturates and diazepam is indicated, which should be carried out under constant medical supervision.

White capsules, 10 pieces in a blister.

Green capsules, 10 pieces in a blister.

1 cardboard package of Antigrippin-Anvi contains 1 blister with white capsules and 1 blister with green capsules.

It is recommended to store the drug in a dry place away from direct sunlight at a temperature not exceeding 25 degrees Celsius.

Shelf life – 2 years.

1 white capsule contains:

Metamizole sodium – 250 mg;

Calcium gluconate monohydrate – 100 mg;

Diphenhydramine hydrochloride – 20 mg;

Acetylsalicylic acid – 250 mg;

Ascorbic acid – 300 mg;

Reviews Antigrippin-Anvi

All reviews about Antigrippin-Anvi

Questions and answers

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Source: http://www.medcentre.com.ua/medicamenty/antigrippin-anvi.html

Antigrippin-ANVI

Antigrippin-ANVI: instructions for use and reviews

Latin name: Antigrippin-ANVI

Active ingredient: Acidum acetylsalicylicum & ascorbinicum, Rutosidum, Metamizole sodium, Calcium gluconate (Gluconas calcii), Hydrochloride diphenhydramine

Manufacturer: AnviLab (Russia)

Update of description and photo: 07/27/2017

Prices in pharmacies: from 90 rubles.

Antigrippin-ANVI is a combination drug for the symptomatic treatment of colds.

Release form and composition

  • capsules A: size No. 0, hard gelatin, green; contents – a mixture of granules and powder (there may be lumps), the color of the mixture is from light yellow to yellow with a greenish tint;
  • capsules B: size No. 0, hard gelatin, white; contents – a mixture of granules and powder (there may be lumps), the color of the mixture is white or white with a yellowish tint.

Packing: 10 capsules A in a blister pack, 10 capsules B in a blister pack, 2 blister packs (one A and B each) in a cardboard box.

Composition of capsule A:

  • active ingredients: ascorbic acid – 300 mg, acetylsalicylic acid – 250 mg, rutoside trihydrate – 20 mg (in terms of rutoside);
  • auxiliary components: potato starch, calcium stearate;
  • capsule shell: gelatin, titanium dioxide (E 171), brilliant black dye (E 151), azorubine dye (E 122), quinoline yellow dye (E 104), brilliant blue dye (E 133) or proprietary blue dye (E 131) .

Composition of capsule B:

  • active ingredients: metamizole sodium monohydrate – 250 mg, calcium gluconate monohydrate – 100 mg, diphenhydramine hydrochloride – 20 mg;
  • auxiliary components: potato starch, calcium stearate;
  • capsule shell: gelatin, titanium dioxide (E 171).

Pharmacological properties

Antigrippin-ANVI has anti-cold, antipyretic, analgesic, anti-inflammatory, antihistamine and angioprotective effects.

Pharmacodynamics

The effect of the drug is due to the properties of its constituent components:

  • ascorbic acid helps increase the body's resistance, plays an important role in tissue regeneration, blood clotting, regulation of carbohydrate metabolism and redox processes;
  • acetylsalicylic acid (ASA) inhibits platelet aggregation, has anti-inflammatory, analgesic and antipyretic effects;
  • rutoside (rutin) – an angioprotector that reduces capillary permeability, inflammation and swelling; inhibits red blood cell aggregation and increases the degree of their deformation;
  • metamizole sodium (analgin) has an antipyretic and analgesic effect; inhibits the synthesis of prostaglandins, due to which it also has a weak anti-inflammatory property;
  • calcium gluconate reduces vascular permeability, has an antiallergic effect, and participates in the regulation of calcium and phosphorus metabolism;
  • diphenhydramine (diphenhydramine) has a decongestant, antiallergic and local anesthetic effect (reduces vascular permeability, eliminates sore throat, hyperemia and swelling of the nasal mucosa, as well as allergic reactions from the upper respiratory tract).

Indications for use

Antigrippin-ANVI is used for the symptomatic treatment of colds, acute respiratory viral infections and influenza in adults and adolescents over 15 years of age.

Contraindications

  • diseases accompanied by bronchospasm;
  • aspirin and bronchial asthma;
  • increased tendency to bleed;
  • gastrointestinal bleeding;
  • erosive and ulcerative lesions of the gastrointestinal tract (GIT) in the acute phase;
  • inhibition of hematopoiesis (leukopenia, agranulocytosis, neutropenia);
  • hemorrhagic diathesis (von Willebrand disease, thrombocytopenia, hemophilia, hypoprothrombinemia, telangiectasia, thrombocytopenic purpura);
  • deficiency of glucose-6-phosphate dehydrogenase;
  • hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase;
  • calcium nephrolithiasis, hypercalciuria;
  • hypercalcemia;
  • vitamin K deficiency;
  • sarcoidosis;
  • severe liver or kidney dysfunction;
  • portal hypertension;
  • dissecting aortic aneurysm;
  • intoxication with cardiac glycosides;
  • age up to 15 years;
  • pregnancy;
  • lactation;
  • hypersensitivity to the components of the drug.

Antigrippin-ANVI should be used with caution in cases of decompensated heart failure, gout, hyperuricemia, urate nephrolithiasis, or a history of gastric and/or duodenal ulcers.

Instructions for use Antigrippin-ANVI: method and dosage

Antigrippin-ANVI is taken orally: the capsules are swallowed whole with water after meals.

Adults and adolescents over 15 years old are prescribed 2 capsules at a time - 1 green (from blister A) and 1 white (from blister B).

Frequency of administration: 2–3 times a day.

The duration of treatment is until the symptoms of the disease disappear, but not more than 5 days. If you do not feel better, consult a doctor.

Side effects

  • allergic reactions: skin rashes, Quincke's edema, bronchospasm;
  • from the cardiovascular system: increased blood pressure, tachycardia;
  • from the digestive system: gastrointestinal bleeding, erosive and ulcerative lesions of the gastrointestinal tract, nausea, gastralgia, anorexia, diarrhea, vomiting, liver failure;
  • other: renal failure.

With long-term use of the drug (longer than 7 days), the following side effects may occur:

  • allergic reactions: toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, anaphylactic shock;
  • from the central nervous system: dizziness, headache;
  • from the blood coagulation system: hypocoagulation, decreased platelet aggregation, hemorrhagic syndrome (including purpura, bleeding gums, nosebleeds);
  • from the hematopoietic system: agranulocytosis, thrombocytopenia, leukopenia;
  • from the urinary system: red staining of urine, anuria, oliguria, interstitial nephritis, proteinuria, impaired renal function, kidney damage with papillary necrosis;
  • from the senses: tinnitus, deafness, visual impairment;
  • others: in children - Reye's syndrome (liver dysfunction, vomiting, metabolic acidosis, hyperpyrexia, mental and nervous system disorders).

Overdose

The following symptoms may indicate an overdose of Antigrippin-ANVI: ringing in the ears, pale skin, sweating, nausea, stomach pain, vomiting, tachycardia. With a significant overdose, the following are possible: anuria, drowsiness, difficulty breathing, bronchospasm, collapse, bleeding, convulsions, respiratory acidosis, progressive respiratory paralysis.

When taking an excessive dose of the drug, it is necessary to artificially induce vomiting and rinse the stomach, take activated charcoal and a saline laxative. In case of convulsive syndrome, intravenous administration of barbiturates and diazepam is indicated. If necessary, hemodialysis and forced diuresis are performed.

special instructions

In low doses, ASA reduces the excretion of uric acid from the body, which is why there is a risk of a gout attack.

ASA has antiplatelet properties, therefore, during an upcoming surgical intervention, it is necessary to warn the attending physician about taking the drug.

With hay fever and bronchial asthma, the likelihood of developing hypersensitivity reactions is increased.

Ascorbic acid can aggravate the course of rapidly proliferating and intensively metastasizing tumors.

Antigrippin-ANVI contains sodium metamizole, so its simultaneous use with penicillin, colloidal blood substitutes and radiocontrast agents is contraindicated.

The ascorbic acid contained in the drug may distort the results of some laboratory tests, for example, to determine the activity of liver transaminases, the content of bilirubin, glucose and lactate dehydrogenase in the blood plasma.

Antigrippin-ANVI is not recommended to be taken during therapy with ticlopidine, anticoagulants, glucocorticosteroids, antihypertensive and uricosuric drugs.

During treatment, you should refrain from drinking alcohol, since ethanol increases the risk of gastrointestinal bleeding.

Ascorbic acid stimulates the synthesis of corticosteroid hormones, so monitoring of kidney function and blood pressure is required.

With prolonged treatment, it is necessary to monitor laboratory indicators of the functional state of the liver and the picture of peripheral blood.

Impact on the ability to drive vehicles and complex mechanisms

Patients taking Antigrippin-ANVI should refrain from potentially dangerous activities that require quick reactions and increased attention.

Use during pregnancy and lactation

Antigrippin-ANVI is not prescribed during pregnancy, since ASA has a teratogenic effect: when used in the first trimester, it can cause cleft palate, in the third trimester - premature closure of the ductus arteriosus in the fetus, as a result of which the development of pulmonary vascular hyperplasia and hypertension in the small vessels is possible. circulation, as well as inhibition of labor. In the second trimester, the drug can be used only as prescribed by a doctor if the expected benefits outweigh the potential risks.

ASA passes into breast milk, which can cause platelet dysfunction and, as a result, bleeding in the baby. For this reason, if therapy is necessary during lactation, breastfeeding should be temporarily stopped.

Use in childhood

According to the instructions, Antigrippin-ANVI is contraindicated in patients under 15 years of age. When ASA is used as an antipyretic for acute respiratory viral diseases in children under 15 years of age, there is a high risk of developing Reye's syndrome, manifested by encephalopathy and acute fatty liver degeneration with acute development of liver failure.

For impaired renal function

The use of the drug is contraindicated in patients with severe renal impairment.

For liver dysfunction

The use of the drug is contraindicated in patients with severe liver dysfunction and portal hypertension.

Drug interactions

In case of simultaneous use of Antigrippin-ANVI:

  • enhances the effect of steroid hormones, indirect anticoagulants, hypoglycemic agents, reserpine, heparin;
  • reduces the effect of uricosuric drugs, antihypertensive drugs, furosemide, spironolactone;
  • enhances the side effects of non-steroidal anti-inflammatory drugs, non-narcotic analgesics, sulfonylurea derivatives, glucocorticosteroids, methotrexate.

With the combined use of ethanol or ethanol-containing drugs, antiepileptic drugs, barbiturates, rifampicin, zidovudine, the risk of developing hepatotoxicity increases, and therefore these combinations should be avoided.

Metamizole sodium enhances the effects of ethanol and reduces the level of cyclosporine in the blood. Its analgesic effect is enhanced by tranquilizers and sedatives. Allopurinol, oral contraceptives and tricyclic antidepressants disrupt its metabolism and increase toxicity.

Melphalan and thiamazole in combination with metamizole sodium increase the risk of developing leukopenia.

Ascorbic acid improves the absorption of iron in the intestines.

Analogs

Analogues of Antigrippin-ANVI are Antigrippin, Antigrippin pharmaceutical, Antigrippin-Maximum, FluZiOZ-F.

Terms and conditions of storage

Store for no more than 2 years out of reach of children, in a dry place, protected from light, at temperatures up to 25 °C.

Conditions for dispensing from pharmacies

Available without a prescription.

Reviews about Antigrippin-ANVI

According to reviews, Antigrippin-ANVI is a popular drug. However, users' opinions regarding the drug are quite contradictory. Some patients confirm the effectiveness of the drug, while others note the development of side effects and the short duration of the therapeutic effect or its complete absence.

Price for Antigrippin-ANVI in pharmacies

The price for Antigrippin-ANVI is 125–165 rubles per pack of 20 capsules.

Antigrippin-anvi capsules n20

Antigrippin-ANVI capsules 20 pcs.

Antigrippin-anvi caps./set n20

Antigrippin-anvi No. 20 caps.

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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When lovers kiss, each of them loses 6.4 calories per minute, but at the same time they exchange almost 300 types of different bacteria.

If your liver stopped working, death would occur within 24 hours.

The highest body temperature was recorded in Willie Jones (USA), who was admitted to the hospital with a temperature of 46.5°C.

American scientists conducted experiments on mice and came to the conclusion that watermelon juice prevents the development of vascular atherosclerosis. One group of mice drank plain water, and the second group drank watermelon juice. As a result, the vessels of the second group were free of cholesterol plaques.

The average life expectancy of left-handers is shorter than that of right-handers.

Most women are able to derive more pleasure from contemplating their beautiful body in the mirror than from sex. So, women, strive to be slim.

A job that a person doesn’t like is much more harmful to his psyche than no job at all.

A person taking antidepressants will, in most cases, become depressed again. If a person has coped with depression on his own, he has every chance to forget about this condition forever.

There are very interesting medical syndromes, for example, compulsive swallowing of objects. One patient suffering from this mania had 2,500 foreign objects in her stomach.

Research shows that women who drink several glasses of beer or wine per week have an increased risk of developing breast cancer.

The rarest disease is Kuru disease. Only members of the For tribe in New Guinea suffer from it. The patient dies of laughter. The disease is believed to be caused by eating human brains.

The human brain weighs about 2% of the total body weight, but it consumes about 20% of the oxygen entering the blood. This fact makes the human brain extremely susceptible to damage caused by a lack of oxygen.

Regular use of a solarium increases your chance of developing skin cancer by 60%.

The human stomach copes well with foreign objects without medical intervention. It is known that gastric juice can even dissolve coins.

Every time a child has a fever, a sore throat, a runny nose and a cough, parents are worried about the question - is it a common cold or the flu? In this

Source: http://www.neboleem.net/antigrippin-anvi.php

ANTIGRIPPIN-ANVI

Capsules A, hard gelatin, size No. 0, green; the contents of the capsules are a mixture of crystalline and amorphous powder from light yellow to yellow with a greenish tint, the presence of lumps is allowed (10 pcs. in a contour cell package).

Excipients: calcium stearate - 1 mg, potato starch - 9 mg.

Composition of hard gelatin capsules: gelatin - 90.723 mg, azorubine dye (E122) - 0.003 mg, brilliant black dye (E151) - 0.184 mg, proprietary blue dye (E131) or brilliant blue dye (E133) - 0.315 mg, quinoline yellow dye ( E104) - 2.207 mg, titanium dioxide (E171) - 2.56 mg.

Capsules B, hard gelatin, size No. 0, white; the contents of the capsules are powder and/or granules of white or white with a yellowish tint, the presence of lumps is allowed (10 pieces in a contour cell package).

Excipients: calcium stearate - 3.8 mg, potato starch - 6.2 mg.

Composition of hard gelatin capsules: gelatin - 91.944 mg, titanium dioxide (E171) - 4.055 mg.

20 pcs. (10 capsules A green and 10 capsules B white) - contour cell packaging (2) - cardboard packs.

Combination drug.

Acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory effects; inhibits platelet aggregation.

Ascorbic acid plays an important role in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and helps increase the body's resistance.

Rutoside (rutin) is an angioprotector. Reduces capillary permeability, reduces swelling and inflammation, strengthens the vascular wall. Inhibits aggregation and increases the degree of deformation of red blood cells.

Metamizole sodium has an analgesic, antipyretic and weak anti-inflammatory effect, the mechanism of which is associated with inhibition of prostaglandin synthesis.

Diphenhydramine has an antiallergic, decongestant, local anesthetic effect (reduces vascular permeability, eliminates swelling and hyperemia of the nasal mucosa, sore throat and manifestations of allergic reactions in the upper respiratory tract).

Calcium gluconate is a regulator of calcium and phosphorus metabolism, has an antiallergic effect (the mechanism is unclear), and reduces vascular permeability. For allergic diseases or conditions, its combined use with antihistamines is recommended.

- erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);

- increased tendency to bleeding;

- bronchial asthma and diseases accompanied by bronchospasm (including “aspirin” asthma);

- inhibition of hematopoiesis (agranulocytosis, neutropenia, leukopenia);

- severe liver dysfunction;

- severe renal dysfunction;

- hereditary hemolytic anemia (including those associated with deficiency of glucose-6-phosphate dehydrogenase);

- hemorrhagic diathesis (hemophilia, von Willebrand disease, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura);

- dissecting aortic aneurysm;

— hypercalcemia (calcium ion concentration should not exceed 12 mg% or 6 meq/l);

— intoxication with cardiac glycosides (risk of arrhythmia);

- lactation period (breastfeeding);

- children and adolescents up to 15 years of age;

- hypersensitivity to the components of the drug.

with caution for hyperuricemia, urate nephrolithiasis, gout, gastric and duodenal ulcers (history), decompensated heart failure.

The drug is taken orally, after meals, with water, 2-3 times a day for 3-5 days until the symptoms of the disease disappear.

Adults and adolescents over 15 years of age are prescribed 2 capsules per dose: 1 green capsule (from blister A) and 1 white capsule (from blister B).

The patient should be warned that if there is no improvement in health, the drug should be stopped and consult a doctor.

Allergic reactions: skin rash, Quincke's edema, bronchospasm.

From the urinary system: renal failure.

From the cardiovascular system: increased blood pressure, tachycardia.

From the digestive system: anorexia, nausea, vomiting, gastralgia, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding, liver failure.

Side effects observed with long-term use of the drug (more than 7 days)

From the side of the central nervous system: dizziness, headache.

From the senses: visual impairment, tinnitus, deafness.

From the hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis.

From the blood coagulation system: decreased platelet aggregation, hypocoagulation, hemorrhagic syndrome (including nosebleeds, bleeding gums, purpura).

From the respiratory system: with a tendency to bronchospasm, an attack may be provoked.

From the urinary system: kidney damage with papillary necrosis, renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, red staining of urine due to the release of a metabolite.

Allergic reactions: anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

Other: in children - Reye's syndrome (hyperpyrexia, metabolic acidosis, nervous system and mental disorders, vomiting, liver dysfunction).

The patient should be warned that all side effects, incl. not listed above, you should inform your doctor and stop taking the drug.

Symptoms: nausea, vomiting, stomach pain, sweating, pale skin, tachycardia; with a slight overdose - ringing in the ears; in case of severe overdose - drowsiness, collapse, convulsions, bronchospasm, difficulty breathing, anuria, bleeding, progressive respiratory paralysis and respiratory acidosis (due to uncoupling of oxidative phosphorylation).

Treatment: artificial vomiting, gastric lavage, administration of saline laxatives, activated carbon; with the development of convulsive syndrome - intravenous administration of diazepam and barbiturates; if necessary, forced diuresis and hemodialysis.

With simultaneous use, Antigrippin-ANVI enhances the effect of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic agents.

With simultaneous use, Antigrippin-ANVI reduces the effectiveness of spironolactone, furosemide, antihypertensive and uricosuric drugs.

Antigrippin-ANVI increases the adverse reactions of GCS, sulfonylurea derivatives, methotrexate, non-narcotic analgesics and NSAIDs.

When using the drug Antigrippin-ANVI simultaneously with barbiturates, antiepileptic drugs, zidovudine, rifampicin and alcohol-containing drugs, the risk of hepatotoxicity increases. These combinations should be avoided.

Ascorbic acid improves the absorption of iron preparations in the intestines.

Tricyclic antidepressants, oral contraceptives and allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity.

Metamizole sodium enhances the effects of alcohol-containing drinks.

The simultaneous use of metamizole sodium with cyclosporine reduces the level of the latter in the blood plasma.

When used simultaneously with metamizole sodium, thiamazole and melphalan increase the risk of developing leukopenia.

Sedatives and tranquilizers enhance the analgesic effect of metamizole sodium.

Radiocontrast agents, colloidal blood substitutes and penicillin should not be used while using metamizole sodium.

With prolonged use of the drug, it is necessary to monitor the peripheral blood picture and laboratory indicators of the functional state of the liver.

Since acetylsalicylic acid has an antiplatelet effect, the patient, if he is undergoing surgery, must notify the doctor in advance about taking the drug.

Acetylsalicylic acid in low doses reduces the excretion of uric acid, which can in some cases provoke a gout attack.

While using the drug, patients should avoid drinking alcoholic beverages due to the increased risk of gastrointestinal bleeding.

Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor renal function and blood pressure.

Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process.

Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (determination of glucose, bilirubin, liver transaminase activity, LDH in blood plasma).

In patients with bronchial asthma and hay fever, hypersensitivity reactions may develop when taking the drug.

Use in pediatrics

The drug is not prescribed as an antipyretic to children under 15 years of age with acute respiratory viral diseases due to the risk of developing Reye's syndrome (encephalopathy and acute fatty liver with acute development of liver failure).

Impact on the ability to drive vehicles and operate machinery

During the period of use of the drug, you should refrain from engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions.

The drug is contraindicated for use during pregnancy. Acetylsalicylic acid has a teratogenic effect: when used in the first trimester of pregnancy, it leads to the development of cleft palate; in the third trimester - to premature closure of the ductus arteriosus in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the pulmonary circulation, and to inhibition of labor (due to inhibition of prostaglandin synthesis).

Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in the baby due to impaired platelet function. If it is necessary to prescribe during lactation, breastfeeding should be stopped for the period of use of the drug.

Contraindicated in severe renal impairment, nephrolithiasis (calcium).

with caution for urate nephrolithiasis.

Contraindicated in severe liver dysfunction and portal hypertension.

The drug should be stored out of the reach of children, in a dry, dark place at a temperature not exceeding 25°C. Shelf life – 2 years.

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Reviews for Antigrippin-ANVI

Release form: Capsules

Ainur added a negative review to Antigrippin-ANVI

Unfortunately it didn't suit me

During the epidemic season of ARVI and influenza, first my child got sick, I caught the virus from him, and then we infected our dad. By that time, I was no longer breastfeeding, so I decided to undergo treatment with aspirin-containing medications, fortunately they cope with cold symptoms quickly. I sent my husband to the pharmacy, where they sold him this drug. At home, I scolded him for being too expensive, when I could buy it much cheaper with the same composition. The drug is a capsule of white and green colors. They should be taken after meals. But the fact is that due to intoxication, I had absolutely no appetite and had to take the capsules on an empty stomach. Probably for this reason I felt nauseated, and by nightfall I started vomiting. My husband had no such symptoms. Perhaps it was an individual reaction. I didn’t take any more risks and stopped taking it. But the drug helped my husband. Therefore, I don’t even know whether to recommend Antigrippin-Anvi or not.

Evgenia added a negative review to Antigrippin-ANVI

We overpay and are deceived

I bought it in November, just when the cold season started. Cost about 200 rubles for 20 capsules. The whole family drank, including my 16-year-old son. By the way, the drug can only be taken from 15 years of age. The capsules are multi-colored, green and white. Take one of each type at a time after meals; you need to take it twice a day in total. In fact, it doesn’t work out economically - a package is enough for 5 days, and although the course of treatment is just 5-7 days, if the whole family drinks it, it’s expensive. It’s not an antibiotic, not something powerful, just aspirin with vitamin C, and we bought into the delight of friends. Yes, there seems to be something in capsule B that is supposed to boost immunity, but in reality we didn’t see any effect. I started drinking from the first symptoms of ARVI, and the effect was the simplest - the drug lowered the temperature, and that’s all. I was still sick for a week with all the consequences, I also got otitis (I have such a tendency), that is, except for the antipyretic properties, nothing has changed, I didn’t even get better faster. My son and husband were already sick when they started drinking (it was the third day), so I couldn’t even really lower their temperature.

Irina added a negative review to Antigrippin-ANVI

Not the best

My husband often gets colds. We bought a lot of different medications, recently only in tablets or capsules. And literally, yesterday I bought Antigrippin. Very expensive. I would buy regular paracetamol for the whole village. But okay, it’s already accepted in our country that if it’s very expensive, it’s very effective and fast. But there was no particular effect after taking 2 tablets. As he sneezed, he continued. We took 2 more tablets - again nothing. And so on for 4 days. Neither I nor my husband noticed any effect. I don’t know why this is, maybe his body is such that it’s better to put the powder in water and take it, since our cheapest drug Negrinpin relieved lacrimation after taking the first sachet. But I gave the remaining tablets to my mother-in-law, she also did not feel the effect. I read the instructions, there is no paracetamol, but a bunch of other substances. And not very understandable. Perhaps this is why there is no effect, that all these substances are powerless without paracetamol. I will never buy again, as I am very disappointed by both the very low price and the lack of visible effect.

Veronica added a neutral review

I didn't see anything special

I caught a cold and started self-medicating. Antigrippin-ANVI was recommended by a pharmacist at a pharmacy. It is available without a doctor's prescription, but it would be better if I first read the ingredients and then decided whether to buy it or not. Already at home I discovered that the drug contains the usual acetylsalicylic acid and ascorbic acid. It’s not so offensive that I bought at an inflated price the same thing that is available at home in separate form in ordinary tablets, acetyl and ascorbic acid, but the fact that the pharmacist didn’t even explain the composition, didn’t say that I was taking the same thing, only expensive. In principle, I was always treated with paracetamol and acetyl, but then I thought, maybe there’s a new medicine and I’ll recover faster. One good thing is that it’s in capsules. I feel the effect from them faster than from regular tablets.

Valentina added a positive review to Antigrippin-ANVI

Helps, but not always

Our family often catches colds, especially with the onset of cold weather. And the flu is not a rare visitor to us. There are a lot of antiviral drugs in the home medicine cabinet, including Antigrippin Anvi. I can’t say anything bad about him, but I won’t admire him either. Yes, in the very early stages it really alleviates the condition and contributes to a more gentle and fleeting course of the disease, however, if the case is advanced, then the drug is practically useless here. And its price is quite decent.

Alena added a positive review to Antigrippin-ANVI

Eliminates flu symptoms quickly

Flu and ARVI have become winter companions for schoolchildren and adults. Some old-school doctors advise taking home remedies, honey and tea, onions and garlic, but do they really help as quickly and effectively as antibiotics? After I heard that people’s temperature rises above 38 and 39 degrees, and they don’t go to the hospital and are treated at home, and then die, I realized that I need to immediately go to the doctor and take everything he prescribes. Antigrippin helped me within 4 days, but with standard old-fashioned methods I would have suffered for a week or more. I recommend it to all thinking adults.

Alexander added a neutral review

But the temperature still drops a little

Now the number of different drugs is simply off the charts. Recently my wife got sick. Some lady in line at the store sneezed on her and the next evening this sneeze made itself felt. Fever, chills, dry throat, in short the bouquet was complete. We don’t keep enough pills at home, so we turned to our neighbor. She suggested this same Antigripin. We must pay tribute, the temperature from 39.8 dropped exactly one degree, she took the pills for three days, then stopped. There were no further improvements. and then began the usual treatment. That is, using home, proven remedies. Tea with lemon and pine cone jam, just aspirin and by the end of the week everything was gone. I don’t know what helped more, but I am inclined to believe that traditional medicine provided more help.

. LekReviews.com / All information is presented for informational purposes only and cannot be used as a recommendation for treatment.

Source: http://lekotzyvy.com/preparat/a/antigrippin-anvi-ceny-s-otzyvami/