Antibiotic trifion

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Tavanik - instructions for use of the antibiotic, reviews, analogs and release forms (250 mg and 500 mg tablets, injections in injection ampoules) of a drug for the treatment of prostatitis, cystitis and pyelonephritis in adults, children and pregnancy

In this article you can read the instructions for use of the drug Tavanik.

Table of contents:

Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of the antibiotic Tavanik in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Tavanik in the presence of existing structural analogues. Use for the treatment of prostatitis, cystitis and pyelonephritis in adults, children, as well as during pregnancy and lactation.

Tavanic is a synthetic antimicrobial drug from the group of fluoroquinolones, a levorotatory isomer of ofloxacin. Has a wide spectrum of antimicrobial action.

Levofloxacin (the active ingredient of the drug Tavanik) blocks DNA gyrase (topoisomerase 2) and topoisomerase 4, disrupts supercoiling and cross-linking of DNA breaks, inhibits DNA synthesis, causes profound morphological changes in the cytoplasm, cell wall and membranes.

Levofloxacin is active against most strains of microorganisms.

Aerobic gram-positive and gram-negative microorganisms are sensitive; anaerobic microorganisms; other microorganisms: Bartonella spp., Chlamydia pneumoniae (chlamydia), Chlamydia psittaci, Chlamydia trachomatis, Legionella pneumophila (legionella), Legionella spp., Mycobacterium spp. (including Mycobacterium leprae, Mycobacterium tuberculosis), Mycoplasma hominis (mycoplasmas), Mycoplasma pneumoniae, Rickettsia spp., Ureaplasma urealyticum (ureaplasmas).

Aerobic gram-positive microorganisms are resistant to Tavanic: Corynebacterium jeikeium, Staphylococcus aureus (methicillin-resistant strains), Staphylococcus spp. (coagulase-negative methicillin-resistant strains); aerobic gram-negative microorganisms: Alcaligenes xylosoxidans; anaerobic microorganisms: Bacteroides thetaiotaomicron; other microorganisms: Mycobacterium avium.

Due to the peculiarities of the mechanism of action of levofloxacin, cross-resistance is usually not observed between Tavanic and other antimicrobial agents.

Levofloxacin hemihydrate + excipients.

Plasma protein binding%. Levofloxacin penetrates well into the bronchial mucosa, epithelial lining fluid, alveolar macrophages with penetration coefficients into the bronchial mucosa and epithelial lining fluid compared to the concentration in plasma. Levofloxacin penetrates well into lung tissue with penetration coefficients of 2-5 compared to plasma concentrations. Levofloxacin penetrates well into the alveolar fluid with a penetration coefficient compared to plasma concentrations of 1. Levofloxacin penetrates well into cortical and cancellous bone tissue, both in the proximal and distal parts of the femur with a penetration coefficient (bone tissue/plasma) of 0. 1-3. Levofloxacin penetrates poorly into the cerebrospinal fluid. Levofloxacin penetrates well into prostate tissue. High concentrations of levofloxacin are created in the urine, several times higher than the concentrations of levofloxacin in plasma.

Levofloxacin is metabolized to a small extent (5% of the dose taken). Its metabolites are demethyllevofloxacin and levofloxacin N-oxide, which are excreted by the kidneys. Levofloxacin is stereochemically stable and does not undergo chiral transformations.

There are no significant differences in the pharmacokinetics of levofloxacin when administered intravenously and orally, which confirms that oral and intravenous routes of administration are interchangeable.

Bacterial infections caused by microorganisms sensitive to levofloxacin in adults:

  • acute sinusitis;
  • exacerbation of chronic bronchitis;
  • community-acquired pneumonia;
  • uncomplicated urinary tract infections;
  • complicated urinary tract infections (including pyelonephritis);
  • chronic bacterial prostatitis;
  • infections of the skin and soft tissues;
  • septicemia/bacteremia associated with the above indications;
  • abdominal infections;
  • for complex treatment of drug-resistant forms of tuberculosis.

Film-coated tablets 250 mg and 500 mg.

Solution for infusion (injections in injection ampoules).

Instructions for use and dosage

The drug is taken orally at 250 or 500 mg 1 or 2 times a day. The tablets should be taken without chewing and with a sufficient amount of liquid (0.5 to 1 glass). If necessary, tablets can be broken along the dividing groove.

The drug can be taken before meals or at any time between meals, because. food intake does not affect the absorption of the drug.

The drug should be taken at least 2 hours before or 2 hours after taking antacids containing magnesium and/or aluminum, iron salts or taking sucralfate.

The dosage regimen is determined by the nature and severity of the infection, as well as the sensitivity of the suspected pathogen. The duration of treatment varies depending on the course of the disease.

For patients with normal or moderately reduced renal function (creatinine clearance >50 ml/min), the following dosage regimen and duration of treatment are recommended.

Acute sinusitis: 2 tablets of 250 mg or 1 tablet of 500 mg 1 time per day (respectively 500 mg of levofloxacin) days.

Exacerbation of chronic bronchitis: 1 tablet 250 mg (respectively 250 mg levofloxacin) or 2 tablets 250 mg or 1 tablet 500 mg 1 time per day (respectively 500 mg levofloxacin) days.

Community-acquired pneumonia: 2 tablets of 250 mg or 1 tablet of 500 mg 1-2 times a day (corresponding to levofloxacin) days.

Uncomplicated urinary tract infections: 1 tablet 250 mg 1 time per day (respectively 250 mg levofloxacin) - 3 days.

Complicated urinary tract infections (including pyelonephritis): 1 tablet 250 mg 1 time per day (respectively 250 mg levofloxacin) days.

Chronic bacterial prostatitis: 2 tablets of 250 mg or 1 tablet of 500 mg 1 time per day (respectively 500 mg of levofloxacin) - 28 days.

Infections of the skin and soft tissues: 1 tablet of 250 mg 1 time per day (respectively 250 mg of levofloxacin) or 2 tablets of 250 mg or 1 tablet of 500 mg 1-2 times a day (respectively 250 mg of levofloxacin) days.

Septicemia/bacteremia associated with the above indications: 2 tablets of 250 mg or 1 tablet of 500 mg 1-2 times a day (corresponding to levofloxacin) days.

Infections of the abdominal cavity: 2 tablets of 250 mg or 1 tablet of 500 mg 1 time per day (respectively 500 mg of levofloxacin) days in combination with antibacterial drugs acting on anaerobic flora.

As part of complex therapy for drug-resistant forms of tuberculosis: 1-2 tablets of 500 mg 1-2 times a day (corresponding to levofloxacin) - up to 3 months.

For elderly patients, no dosage adjustment is required.

If you accidentally miss taking the drug, you should take the tablet as soon as possible and then continue to take Tavanik according to the recommended dosage regimen.

The drug is taken orally or administered intravenously 1-2 times a day.

Doses are determined by the nature and severity of the infection, as well as the sensitivity of the suspected pathogen.

For patients with normal or moderately impaired renal function (creatinine clearance >50 ml/min), the drug is recommended to be prescribed in the following doses.

Community-acquired pneumonia: 500 mg 1-2 times a day (daily dose 0 mg of levofloxacin). Course of treatment days.

Uncomplicated urinary tract infections: 250 mg 1 time per day (daily dose of levofloxacin). The course of treatment is 3 days.

Complicated urinary tract infections (including pyelonephritis): 250 mg 1 time per day. For severe infections, the dose may be increased. Course of treatment days.

Chronic bacterial prostatitis: 500 mg 1 time per day (daily dose of levofloxacin). The course of treatment is 28 days.

Septicemia/bacteremia: 500 mg 1-2 times a day (daily dose 0 mg of levofloxacin). Course of treatment days.

Infection of the abdominal cavity: 500 mg 1 time per day. A course of treatment of days in combination with antibacterial drugs acting on anaerobic flora.

As part of complex therapy for drug-resistant forms of tuberculosis, Tavanic is prescribed 500 mg 1-2 times a day (mg levofloxacin per day) for up to 3 months.

The duration of treatment varies depending on the course of the disease and should be no more than 14 days.

As with the use of other antibiotics, it is recommended to continue treatment with Tavanic for a minimum period after normalization of body temperature or after reliable eradication of the pathogen.

If the patient’s clinical condition improves after a few days of treatment, you can switch from intravenous drip administration to oral administration of the drug Tavanik in tablets at the same dose (due to the fact that the bioavailability of levofloxacin when taken orally is %).

The patient must be warned about the inadmissibility of an independent break or early termination of therapy without the doctor’s instructions.

If the administration of the drug is accidentally missed, then the missed dose should be administered as soon as possible and then continue to administer Tavanik according to the recommended dosage regimen.

Rules for administering the drug

The drug Tavanik in the form of a solution is administered intravenously by drip (dropper) slowly. The duration of administration of the drug at a dose of 500 mg (100 ml of infusion solution/500 mg of levofloxacin) should be at least 60 minutes; in the case of administering half a bottle (50 ml/250 mg of levofloxacin), the duration of administration should be at least 30 minutes. A solution of the drug Tavanik 500 mg/100 ml is compatible with the following infusion solutions: 0.9% sodium chloride solution, 5% dextrose solution, 2.5% Ringer's solution with dextrose, combined solutions for parenteral nutrition (amino acids, carbohydrates, electrolytes). The drug solution should not be mixed with heparin or solutions with an alkaline reaction (for example, sodium bicarbonate solution).

After removing the bottle from the cardboard box, the infusion solution can be stored under room lighting without light protection for no more than 3 days.

  • phlebitis;
  • sinus tachycardia;
  • decrease in blood pressure;
  • leukopenia, eosinophilia, neutropenia, thrombocytopenia, pancytopenia, agranulocytosis, hemolytic anemia;
  • headache;
  • dizziness;
  • drowsiness;
  • tremor;
  • dysgeusia (taste perversion);
  • paresthesia;
  • convulsions;
  • peripheral sensory neuropathy;
  • extrapyramidal disorders;
  • loss of taste;
  • insomnia;
  • feeling of anxiety;
  • confusion;
  • depression;
  • sleep disorders;
  • nightmares;
  • visual disturbances such as blurred vision;
  • vertigo (a feeling of deviation or spinning of one's own body or surrounding objects);
  • tinnitus;
  • hearing loss;
  • dyspnea;
  • bronchospasm;
  • allergic pneumonitis;
  • diarrhea;
  • vomiting, nausea;
  • stomach ache;
  • dyspepsia;
  • pseudomembranous colitis;
  • acute renal failure (for example, due to the development of interstitial nephritis);
  • rash;
  • itching;
  • hives;
  • toxic epidermal necrolysis;
  • exudative erythema multiforme;
  • photosensitivity reactions (increased sensitivity to solar and ultraviolet radiation);
  • angioedema;
  • anaphylactic shock;
  • arthralgia;
  • myalgia;
  • anorexia;
  • asthenia;
  • pyrexia (increased body temperature);
  • reaction at the injection site (pain, skin hyperemia).
  • epilepsy;
  • tendon lesions with a history of fluoroquinolone use;
  • childhood and adolescence up to 18 years of age (due to incomplete growth of the skeleton, since the risk of damage to cartilaginous growth points cannot be completely excluded);
  • pregnancy (the risk of damage to cartilaginous growth points in the fetus cannot be completely excluded);
  • lactation period (the risk of damage to the cartilaginous growth points of bones in an infant cannot be completely excluded);
  • hypersensitivity to levofloxacin or other quinolones.

Use during pregnancy and breastfeeding

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Tavanic is contraindicated for use in children and adolescents under 18 years of age.

Nosocomial infections caused by Pseudomonas aeruginosa may require combination therapy.

The recommended duration of administration should be strictly adhered to, which should be at least 60 minutes for 100 ml of infusion solution. Experience with the use of levofloxacin shows that increased heart rate and a transient drop in blood pressure may occur during infusion. In rare cases, vascular collapse may occur. If a significant drop in blood pressure is observed during the infusion, the administration is stopped immediately.

Patients predisposed to developing seizures

Like other quinolones, levofloxacin should be used with great caution in patients with a predisposition to seizures: in patients with previous lesions of the central nervous system, such as stroke, severe traumatic brain injury; in patients simultaneously receiving drugs that lower the seizure threshold of the brain, such as fenbufen and other similar nonsteroidal anti-inflammatory drugs (NSAIDs), as well as drugs such as theophylline.

Diarrhea that develops during or after treatment with levofloxacin, especially severe, persistent and/or bloody, may be symptoms of pseudomembranous colitis caused by Clostridium difficile. If pseudomembranous colitis is suspected, treatment with levofloxacin should be stopped immediately and specific antibiotic therapy (vancomycin, teicoplanin or oral metronidazole) should be started immediately.

Rarely observed, tendonitis with quinolones, including levofloxacin, can lead to rupture of tendons, including the Achilles tendon. This side effect can develop within 48 hours after starting treatment and can be bilateral. Elderly patients are more prone to developing tendonitis. The risk of tendon rupture may increase when taking corticosteroids simultaneously. If tendonitis is suspected, treatment with Tavanic should be stopped immediately and appropriate treatment of the affected tendon should be initiated, for example by providing adequate immobilization.

Patients with kidney failure

Because Levofloxacin is excreted mainly by the kidneys; in patients with impaired renal function, mandatory monitoring of renal function is required, as well as adjustment of the dosage regimen. When treating elderly patients, it should be borne in mind that patients in this group often suffer from impaired renal function.

Preventing the development of photosensitivity reactions

Although photosensitivity with levofloxacin is very rare, to prevent its development, patients are not recommended to be unnecessarily exposed to strong sunlight or artificial ultraviolet radiation (for example, visiting a solarium).

As with the use of other antibiotics, the use of levofloxacin, especially for a long time, can lead to increased proliferation of microorganisms that are insensitive to it, which can cause changes in the microflora (bacteria and fungi) that are normally present in humans, which can lead to the development of superinfection . Therefore, during treatment, it is imperative to re-evaluate the patient’s condition, and if superinfection develops during treatment, appropriate measures should be taken.

Patients with glucose-6-phosphate dehydrogenase deficiency

Patients with latent or manifest glucose-6-phosphate dehydrogenase deficiency are predisposed to hemolytic reactions when treated with quinolones, which should be taken into account when treating with Tavanic.

In patients with diabetes mellitus receiving oral hypoglycemic agents, such as glibenclamide or insulin, the risk of hypoglycemia increases with the use of quinolones. In these patients with diabetes mellitus, careful monitoring of blood glucose concentrations is required.

Sensory and sensorimotor peripheral neuropathy, which may have a rapid onset, has been reported in patients receiving fluoroquinolones, including levofloxacin. If the patient develops symptoms of neuropathy, levofloxacin should be discontinued. This minimizes the possible risk of developing irreversible changes.

Exacerbation of pseudoparalytic myasthenia gravis (myasthenia gravis)

Tavanic should be used with caution in patients with pseudoparalytic myasthenia gravis.

Impact on the ability to drive vehicles and operate machinery

Side effects of Tavanic, such as dizziness or vertigo, drowsiness and visual disturbances, may reduce psychomotor reactions and the ability to concentrate. This may pose a risk in situations where these abilities are of particular importance (for example, when driving a car, when servicing machinery, when performing work in an unstable position).

Combinations requiring caution

No pharmacokinetic interaction of levofloxacin with theophylline was detected.

The concentration of levofloxacin while taking fenbufen increases only by 13%.

However, with the simultaneous administration of quinolones and theophylline, NSAIDs and other drugs that reduce the threshold of convulsive readiness of the brain, a pronounced decrease in the threshold of convulsive readiness of the brain is possible.

In patients treated with levofloxacin in combination with indirect anticoagulants (for example, warfarin), an increase in prothrombin time/INR and/or bleeding was observed, incl. and heavy. Therefore, with the simultaneous use of indirect anticoagulants and levofloxacin, regular monitoring of blood coagulation parameters is necessary.

When simultaneous use of drugs that interfere with the renal tubular secretion of levofloxacin, such as probenecid and cimetidine, caution should be exercised, especially in patients with renal failure. The elimination (renal clearance) of levofloxacin is slowed down by cimetidine by 24% and probenecid by 34%. It is unlikely to be of clinical significance if renal function is normal

Levofloxacin increased T1/2 of cyclosporine by 33%. Because this increase is clinically insignificant; no dose adjustment of cyclosporine is required when used concomitantly with levofloxacin.

When taken simultaneously with glucocorticosteroids (GCS), the risk of tendon rupture increases.

Tavanic, like other fluoroquinolones, should be used with caution in patients receiving drugs that prolong the QT interval (eg, class 1A and 3 antiarrhythmics, tricyclic antidepressants, macrolides).

Clinical and pharmacological studies conducted to study the possible pharmacokinetic interaction of levofloxacin with calcium carbonate, digoxin, glibenclamide, ranitidine and warfarin showed that the pharmacokinetics of levofloxacin when used simultaneously with these drugs does not change sufficiently to be of clinical significance.

Analogues of the drug Tavanik

Structural analogues of the active substance:

Source: http://instrukciya-otzyvy.ru/568-tavanik-po-primeneniyu-antibiotik-analogi-tabletki-ukoly-v-ampulah-prostatit-cistit.html

Antibiotic trifion

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IACMAH, together with the Russian Society of Urology (ROU), plans to conduct a study of the dynamics of antibiotic resistance of pathogens of urinary tract infections in various subpopulations - “DARMIS-2018”

Dear Colleagues! We invite you to take part in a multicenter prospective microbiological monitoring of antibiotic resistance of leading pathogens of community-acquired infections: Streptococcus pneumoniae , Haemophilus influenzae , Streptococcus pyogenes and Moraxella catarrhalis (PEGAS study). Read more…

Since 2015, NIIAH, together with IACMAH, has been planning to conduct a multicenter study to assess the prevalence of mutations of resistance to macrolide antibiotics in Mycoplasma pneumoniae and Mycoplasma genitalium . Read more…

In the section of the Chief Freelance Specialist of the Ministry of Health of Russia on clinical microbiology and antimicrobial resistance, Clinical recommendations for determining the sensitivity of microorganisms to antimicrobial drugs are posted (current version 2.0 2015, registered in the Federal Medical Library in 2016), approved at an extended meeting of the Interregional Association for Clinical Microbiology and Antimicrobial chemotherapy on May 22, 2015 in Moscow.

Added draft clinical guidelines for isolation, identification and determination of sensitivity of Helicobacter pylori to antimicrobial drugs.

Presepsin is a new diagnostic marker that allows differentiating active pulmonary tuberculosis from bacterial community-acquired pneumonia

Efficacy of probiotics in the treatment of non-alcoholic fatty liver

The impact of cyclic use of antibiotics and the “mixing” strategy on antibiotic resistance in the ICU: results of a cluster-randomized crossover study

The importance of various biomarkers in the diagnosis of sepsis in adult patients

About the benefits and necessity of childhood polio vaccination

Procalcitonin and C-reactive protein may help diagnose invasive bacterial infections in children with fever and unknown source of infection

Topical use of benzydamine hydrochloride in the prevention of postoperative sore throat in adult patients undergoing endotracheal intubation: results of a systematic review and meta-analysis

We invite you to take part in the survey “Laboratory Information System (LIS)”

Source: http://www.antibiotic.ru/

Zinnat

Prices in online pharmacies:

Zinnat is a second-generation broad-spectrum antibiotic that belongs to the group of cephalosporins. The medication is used to treat bacterial infections caused by microorganisms sensitive to the active substance of the drug.

Pharmacological action of Zinnat

The active ingredient of this drug is cefuroxime, which is active against gram-negative and gram-positive aerobic bacteria, including strains resistant to penicillin and ampicillin, Staphylococcus aureus, Streptococcus group B, Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Peptococcus spp., Salmonella spp., Neisseria gonorrhoeae, etc.

The antibiotic Zinnat is capable of disrupting the synthesis of cell walls of microorganisms, which explains its bactericidal and bacteriostatic properties, i.e. the medicine inhibits the proliferation of bacteria and causes their death.

The maximum concentration of the drug in the blood is observed 2-3 hours after its use. It should be borne in mind that eating food significantly speeds up the process of absorption of the drug from the gastrointestinal tract. Zinnat is excreted from the body unchanged through the kidneys.

It is important! To the acting substance, the antibiotic Zinnat is insensitive: Clostridium difficile, Bacteroides fragilis, Serratia spp., Citrobacter spp., Streptococcus (Enterococcus) Faecalis, Staphylococcus Epidermidis, Acinetobacter Calcoaceticus, Enterobacter spp., Legionella spp., Proteus vulgaris, Morganella Morganii, Listeria Monocytogenes, Clostridium difficile, Campylobacter spp., Pseudomonas spp., as well as methicillin-resistant strains of Staphylococcus aureus.

Release form

The drug is available in the form:

  • Film-coated tablets containing 125, 250 or 500 mg of cefuroxime;
  • Granules for the preparation of a suspension for internal use containing 125 or 250 mg of cefuroxime;
  • Powder for the preparation of a solution for intravenous and intramuscular administration, 750 mg in a bottle.

Indications for use of Zinnat

According to the instructions, Zinnat is indicated for use for the following diseases:

  • Infections of the upper and lower respiratory tract, such as: acute and chronic bronchitis, brochoecstasy (pathological dilatation of part of the bronchi with changes in the structure of their walls), lung abscess, bacterial pneumonia, infection of the chest organs after surgery;
  • ENT infections: sinusitis, otitis media, pharyngitis, tonsillitis;
  • Infections of the pelvic organs, such as: endometritis, adnexitis, cervicitis;
  • Infections of the genitourinary system: pyelonephritis in acute and chronic form, urethritis, cystitis, gonorrhea, asymptomatic bacteriuria;
  • Diseases of bones and joints, such as: osteomyelitis, septic arthritis and some others;
  • Diseases of soft tissues and skin: impetigo, wound infections, erysipelas, pyoderma, furunculosis, phlegmon, erysipeloid;
  • Meningitis;
  • Sepsis;
  • Lyme disease.

According to reviews, Zinnat is effective in treating all of these diseases if their causative agents were bacteria sensitive to this drug.

Directions for use and dosage

Zinnat tablets and suspension, prepared from granules, are intended for oral use. The drug should be taken during or immediately after a meal. It should be borne in mind that 10 ml of Zinnat suspension corresponds to 250 mg of cefuroxime.

The duration of drug treatment, as a rule, is from 5 to 10 days, but when treating Lyme disease it reaches 20 days.

In most cases, for infectious diseases, adults are prescribed the antibiotic Zinnat 250 mg twice a day. If a patient is suspected of having pneumonia or a severe respiratory tract infection, Zinnat 250 mg is not enough, so the dosage is doubled, i.e. up to 500 mg also twice a day. For genitourinary diseases, the antibiotic is recommended to be taken 2 times a day, 125 mg; for pyelonephritis, Zinnat 250 mg is recommended. For uncomplicated gonorrhea, according to the instructions, Zinnat is taken in a dose of 1 g once a day.

For most infectious diseases, children are prescribed an antibiotic twice a day, but 125 mg, and for children from three months to 12 years, a single dose is calculated based on the child’s weight: 10 mg of cefuroxime per 1 kg of body weight. For infections in severe forms, children from 3 months to 12 years of age are prescribed the drug at the rate of 15 mg per 1 kg, and children over 12 years of age are prescribed Zinnat 250 mg.

If intramuscular or intravenous administration is necessary for adults, the antibiotic is in most cases prescribed 750 mg three times a day, and in severe forms of the disease it is doubled.

For children, injections with this drug are given 3-4 times a day, the dosage is calculated at the rate of 60 mg of cefuroxime per 1 kg of body weight. After a significant improvement in the child’s condition, as prescribed by the doctor, it is possible to switch from parenteral use of the medication to Zinnat tablets or suspension.

Contraindications for use

According to the instructions, Zinnat is contraindicated in patients if they have an allergic reaction to penicillin drugs, hypersensitivity to cephalosporin, bleeding and gastrointestinal diseases, as well as during pregnancy and lactation.

The drug is also not prescribed to children under three months of age.

Side effects of Zinnat

According to reviews of Zinnat, during the use of the drug, unwanted side effects may occur from various body systems:

  • Digestive system: nausea, vomiting, diarrhea, pain and cramps in the abdomen, dysbacteriosis, candidiasis and ulceration of the oral cavity, rarely - enterocolitis, hepatitis, cholestatic jaundice, increased activity of liver enzymes;
  • Genitourinary system: vaginosis, vaginitis, itching in the perineum;
  • Allergic reactions: skin rash, itching, urticaria, fever, rarely - bronchospasm, exudative erythema, anaphylactic shock;
  • Urinary system: dysuria, impaired renal function;
  • Hematopoietic organs: hemolytic anemia, leukopenia, hypoprothrombinemia, thrombocytopenia, eosinophilia;
  • Central nervous system: headaches, hearing impairment, drowsiness, rarely – convulsions;
  • Local reactions: pain, infiltration and irritation at the injection site.

Also, according to reviews, Zinnat can provoke the appearance of thrush in women, which occurs as a result of excessive growth of Candida fungi during the period of use of this medication.

Additional Information

According to the instructions for Zinnat, the medicine should be stored at room temperature in a cool and dry place. Shelf life under recommended conditions is 24 months. The prepared Zinnat suspension should be stored only in the refrigerator, but no more than 10 days.

Prepare the suspension as follows: shake the contents of the bottle well. Using a measuring cup, measure 20 ml of water, pour it into the bottle, close the lid, then shake the container vigorously until the granules are completely dissolved. Then the bottle is returned to its original position and shaken well again.

Zinnat tab. p.p.o. 125mg n10

Zinnat tablets 125 mg 10 pcs.

Zinnat 125 mg No. 10 tablets

Zinnat tablets 125 mg n10

Zinnat gran. d/susp. internal 125mg/5mg 50ml n1 (1.25g)

Zinnat granules 125 mg/5 ml 1.25 g

Zinnat granules for suspension 125 mg/5 ml 50 ml

Every person at least several times in his life has encountered such an unpleasant disease as a runny nose. Most often, a stuffy nose with p.

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Every person can prevent the penetration and development of various infections; the main thing is to know the main dangers that lie in wait.

What we eat every day begins to worry us at the moment when the doctor makes an unexpected diagnosis of “atherosclerosis” or “ischemic pain.”

A smear for oncocytology (Papanicolaou analysis, Pap test) is a method of microscopic examination of cells that are taken from the surface of the skin.

When using materials from the site, the active reference is obligatory.

Source: http://zdorovi.net/preparaty/zinnat.html

Ciproxin is the newest low-toxic broad-spectrum antibiotic from Europe

In 1928, thanks to the carelessness and curiosity of the British bacteriologist Alexander Fleming, antibiotics were born. The first of these was the legendary penicillin, which was produced using fungi of the genus Penicillinum. Over the next 90 years, science has created several generations of antibiotics, and new antibiotics have significantly surpassed their ancestor in effectiveness. Today, antibiotic treatment is carried out through 15 groups of drugs with different mechanisms of action. Each group of drugs targets specific types of bacteria.

Among the new antibiotics, drugs from the group of quinolones and fluoroquinolones have become very popular. These are one of the so-called “broad-spectrum” antibiotics, which destroy the overwhelming number of varieties of bacteria, compensating for inaccuracies in diagnosis. A prominent representative of such antibiotics is Ciproxin. The drug is produced by the reputable pharmacological company Bayer SpA, which over its more than 150-year history has earned worldwide fame for producing high-quality and effective medicines. Bacteria and the diseases they cause, against which Ciproxin is successfully used, are presented in the table.

Ciproxin tablets are taken orally 250 mg 2-3 times a day, in case of severe infection - pomg 2-3 times a day. The tablets should be swallowed whole with a small amount of liquid after meals. When taking the tablet on an empty stomach, the active substance is absorbed faster. More detailed treatment plans for Ciproxin are also presented on our website.

The main active ingredient of the drug Ciproxin is ciprofloxacin. This is one of the most active substances of the second generation of fluoroquinolone antibiotics. The drug inhibits DNA gyrase and topoisomerase, enzymes responsible for reading genetic information in a bacterial cell. Since genetic information cannot be read normally, the processes of cell division become impossible.

Moreover, ciprofloxacin causes morphological changes in bacterial membranes - the cell wall and membrane. This leads to the rapid death of all pathogenic bacteria that caused the infectious disease. Thus, the bactericidal effect of Ciproxin is realized.

The drug is of low toxicity to humans, since the body's cells do not contain DNA gyrase. Ciprofloxacin (Ciproxin) is a highly effective drug that also destroys bacteria resistant to other antibiotics: aminoglycosides, penicillins, cephalosporins and tetracyclines.

Antibiotic tablets are probably the most convenient form of medication because the tablet can be taken anywhere and at any time. The Italian drug is available in the form of tablets in two dosages - Ciproxin 250 mg and Ciproxin 500 mg. For the drug Ciproxin, the photo is presented on our website.

The use of antibiotics is aimed at destroying pathogenic bacteria that destroy body tissues and cause inflammation in them. If you have a question: “can I take antibiotics?” The answer is obvious: “Of course you can!” However, you should clearly understand which antibiotics can be taken for a specific disease.

Many patients immediately start taking antibiotics for coughs. However, it should be remembered that coughing is not only caused by bacteria. The causes may be viral infections and allergic diseases. Antibiotics in this case will not provide a therapeutic effect. Therefore, you should not self-medicate. It is worth contacting a specialist for a high-quality diagnosis of your disease and prescribing effective treatment.

For the drug Ciproxin, the instructions for use describe its excellent therapeutic effect for a huge number of uncomplicated and complicated infections caused by microorganisms sensitive to ciprofloxacin. Antibiotics for inflammation, including Ciproxin, can help the body only if bacteria are the cause of the inflammation.

For adults, Ciproxin is prescribed for infections of the reproductive and urinary systems, gastrointestinal tract, traveler's diarrhea, infections of the skin and soft tissues, bones and joints. Ciproxin is indicated for pneumonia, bronchitis, bronchiectasis, complications of cystic fibrosis and other bacterial lesions of the respiratory system. Effective for otitis media, sinusitis and other infections of the ENT organs. Ciproxin is also used to prevent infectious complications in patients with reduced immunity (after surgery or while taking immunosuppressants).

Ciproxin is prescribed to children for respiratory diseases, including those caused by Pseudomonas aeruginosa. The drug is also effective for urinary tract infections and pyelonephritis. Doctors often use Ciproxin for many other childhood infections when the child is in serious condition.

Taking antibiotics may be accompanied by changes in the normal intestinal microflora. Children are especially sensitive to such drugs. After antibiotics, a child may lose normal flora, which will lead to serious consequences. To prevent antibacterial drugs from causing harm to the body, they must be taken strictly according to the instructions. After antibiotics or directly during treatment, it is necessary to additionally take prebiotics and probiotics in order to prevent intestinal adverse reactions.

For the drug Ciproxin, the price is comparable to the cost of a package of good vitamins, and the effect, when used correctly, is dramatic. If you want to quickly get rid of a bacterial infection, then Ciproxin is exactly the remedy that can kill both a dangerous, difficult-to-diagnose infection that has been walking through the body for years, and an unexpected “gift” received at an intoxicated romantic meeting.

Use the effective European drug Ciproxin to defeat infections caused by a wide variety of pathogenic bacteria. With the Italian antibiotic Ciproxin, you can quickly destroy organ-destroying bacteria and calmly begin to restore the damaged organ.

Source: http://lekarstvo-iz-evropy.ru/ciproksin-novejshij-malotoksichnyj-antibiotik-shirokogo-spektra-dejstvija-iz-evropy

List of new generation broad-spectrum antibiotics

Antibiotics help cope with most diseases. Many people do not like them, considering the drugs to be dangerous to health (“they treat one, the other cripple”). But it’s hard to argue with the fact that these drugs stopped more than one epidemic. Moreover, due to their wide range of uses, people are less likely to die from infectious diseases. As a result, people's life expectancy has increased significantly.

There’s just one problem: viruses and bacteria can mutate and adapt to antibiotics (this property is called antibiotic resistance - the developed immunity of microorganisms to the action of a drug). This is why antibiotics, invented decades ago and considered almost a panacea for all infections, are now poorly effective in treating most diseases.

Scientists are forced to improve medicines, that is, to produce a new generation of drugs. Currently, there are four generations of widely used antibiotics. In this article we will compile a list of the most popular modern drugs of the new generation, analyze their main characteristics, indications, contraindications and prices.

general description

Broad-spectrum antibiotics are drugs with universal action, prescribed to combat a large number of pathogens (including those with an unknown source of infection). Unfortunately, such versatility is a weakness: there is a possibility that antibiotics will begin to fight against beneficial microflora (for example, if the symbiotic intestinal flora is destroyed, dysbiosis occurs). This is why after treatment with broad-spectrum antibiotics, it is necessary to restore normal levels of beneficial bacteria.

New generation drugs are universal and can act on a large number of pathogenic microbes.

The new generation of antibiotics are more effective than their predecessors because bacteria have not yet had time to adapt to them. Besides:

  • new generation antibiotics are considered safer (they have fewer side effects and are not so severe);
  • New generation antibiotics are easy to use - first generation drugs had to be taken 3-4 times a day, while modern antibiotics are enough to be taken 1-2 times;
  • New generation antibiotics are available in different forms. There are even medications in the form of syrups and patches.

What are the most powerful remedies?

Having studied the reviews of doctors and patients, we can identify the most common broad-spectrum antibiotics from the latest generation. We get this list:

Now let's look at each medicine on this list in a little more detail.

Broad-spectrum antibiotics from the list of new generation macrolides. They act due to azithromycin (one capsule contains 250 ml of the substance).

Sumamed is especially effective in combating infections affecting the respiratory tract (angina, sinusitis, bronchitis, pneumonia), skin and soft tissues, the genitourinary system (for example, prostatitis) and the gastrointestinal tract (including intestinal infections). Contraindicated in case of hypersensitivity to macrolides, as well as liver and kidney diseases. It has mild side effects, which distinguishes Sumamed from other broad-spectrum antibiotics. Take one tablet per day for 3 days (the course can then be extended by a doctor).

The price of Sumemd depends on the form of release and packaging: 250 mg capsules, 6 pieces - from 320 rubles; 6 tablets 125 mg - from 290 rubles; 6 tablets 500 mg - from 377 rub.

  • Cefamandole

A drug from the group of cephalosporins of the latest generation. Rarely causes an adaptive reaction in microorganisms, therefore it effectively fights gram-positive and gram-negative bacteria, mycoplasmas, legionella, salmonella, and sexually transmitted pathogens. Often prescribed for colds and intestinal infections. Can be used as an alternative to cephalosporin if resistance to the latter is observed. Effective for the prevention of postoperative infectious complications. One of the disadvantages of the drug is its high price.

Broad-spectrum antibiotic from the list of new generation tetracyclines. The active substance in the composition is doxycycline. Available in the form of 100 mg tablets (10 tablets per package).

Effective in the fight against gram-positive and gram-negative microorganisms, protozoa, anaerobes, and atypical pathogens. Most often prescribed for the treatment of colds, intestinal infections, and prostatitis. Almost does not cause dysbacteriosis. Dosage for adults: 200 mg (2 tablets) once or twice a day. The price of the drug is approximately 280 rubles. per package.

Fourth generation antibiotic from the list of macrolides. The base substance is roxithromycin. Available in the form of tablets with a dosage of 150 mg. A single daily dose of the drug is sufficient. Most often prescribed for upper respiratory tract infections, urogenital diseases (for example, prostatitis), intestinal, and ondotological infections. Not recommended for use in case of renal failure. It is quite expensive - from 800 rubles. for 10 pieces.

Fourth generation antibiotic packaging.

A new generation antibiotic from the list of pharmacological group of aminopenicillins. It has a wide spectrum of action, resistance to the action of beta-lactamase strains. It has a mild effect, therefore it is used for both treatment and prevention. Unlike many fourth-generation antibiotics, it can be prescribed to pregnant and lactating women. Manufactured by Lek Pharma and Lek DD. Available in the form of powder for intravenous administration, powder for oral administration, and tablets. The price of powders for injections is from 200 rubles, powders taken orally are from 60 rubles, tablets 375 mg are from 224 rubles.

Widely used in dentistry.

One of the most affordable broad-spectrum antibiotics. Sold in the form of ampoules for intravenous and intramuscular administration and in the form of capsules. The selective bacteriostatic effect allows its use in cases where other drugs are ineffective due to developed resistance. True, this same quality does not allow Lincomycin to be prescribed as a first-line drug. It is quite toxic and has a list of a large number of side effects and contraindications that you should familiarize yourself with before taking the medicine. The cost of ampoules with solution is from 68 rubles. for 10 pieces; cost of capsules - from 73 rubles.

Prices for antibiotics in pharmacies for different forms and dosages range from 110 to 370 rubles. It has a wide range of uses: respiratory and urinary tract infections, skin and intestinal infections, pelvic inflammation, prostatitis, prevention after abdominal, gynecological and orthopedic surgeries. Belongs to the group of cephalosporins. Twice daily administration is sufficient. As a rule, it is well tolerated, side effects are rare. Unfortunately, it is available only in the form of an injection solution. Price - from 115 rub.

Antibiotic of the new generation cephalosporin group. It is considered one of the most frequently prescribed drugs for most infectious and inflammatory diseases (colds, intestinal, urological, gynecological, prostatitis, etc.). This prevalence is due to the broad spectrum of action of the antibiotic, affordable price, low toxicity, and minimal effect on beneficial bacteria. Can be used for treatment and prevention (for example, in the postoperative period). Available only in the form of a solution for injection.

Another name for the antibiotic is Pancef. Available only in the form of capsules and tablets taken orally. Acts bactericidal (prevents the synthesis of cell walls of pathogens). It has a wide spectrum of action (kills intestinal infections, treats colds, prostatitis, and is used after operations). Unfortunately, this new generation antibiotic has a fairly strong toxic effect on the kidneys and liver, so it is not recommended for use in diseases of these organs. Price - from 397 rub.

A very strong antibiotic of the latest generation from the group of fluoroquinolones. It is a modern analogue of Moxifloxcin. Effective against many known bacterial and atypical pathogens. It has virtually no negative effect on the kidneys and stomach. Such antibiotics can be used as children's medicines, so they are not prescribed in pediatrics. They are quite expensive - from 750 rubles. for 5 pcs.

How to choose

Naturally, it is not enough to familiarize yourself with the list of new generation antibiotics. I would like to say which broad-spectrum antibiotics are the safest and most effective. Unfortunately, it is impossible to single out a specific drug, since each antibiotic has its own characteristics and in each specific case different drugs will be more effective. This is why you should not prescribe drugs for treatment and prevention on your own if you do not have a medical education. For intestinal infections, prostatitis, sore throat or otitis, various antibiotics will be prescribed. It is better to trust a specialist who prescribes medicine based on the diagnosis, stage of the disease, concomitant diseases, as well as the individual characteristics of the patient.

Source: http://egosila.ru/obzory/antibiotiki-shirokogo-spektra-dejstvija-novogo-pokolenija-spisok

Ceftriaxone

Manufacturer: CJSC Pharmaceutical Company LECCO Russia

PBX code: J01DA13

Release form: Liquid dosage forms. Powder for the preparation of solution for injection.

General characteristics. Compound:

Active ingredient: one bottle contains ceftriaxone 0.5 g and 1.0 g in the form of ceftriaxone disodium salt.

Pharmacological properties:

Ceftriaxone is a third generation cephalosporin antibiotic for parenteral use, has a bactericidal effect, inhibits the synthesis of cell wall membranes, in vitro, inhibits the growth of most gram-positive and gram-negative microorganisms. Ceftriaxone is resistant to beta-lactamase enzymes (both penicillinase and cephalosporinase, produced by most gram-positive and gram-negative bacteria). Effective against the following microorganisms:

Indications for use:

Directions for use and dosage:

Features of application:

Side effects:

Interaction with other drugs:

Contraindications:

Overdose:

Excessively high plasma concentrations of ceftriaxone cannot be lowered by hemodialysis or peritoneal dialysis. Symptomatic measures are recommended to treat cases of overdose.

Storage conditions:

Vacation conditions:

Package:

Published: Aug 13, 2012

Reviews of Ceftriaxone

Nikolay April 24, 2017 at 01:27

Hello！I got a sore throat, the doctor prescribed ceftriaxone. On the second day of illness and injections, my right kidney began to drag, but I didn’t pay attention. In the morning I got another injection, and towards lunch my kidney began to feel better and better. And by nightfall I called an ambulance, because... I was climbing up the wall from the pain in the area of ​​both kidneys, so I decided to finish my course of injections, having done exactly half of them. Maybe, of course, it’s not his fault, which my wife and the emergency doctor and I very much doubted.

Rinat 04 Aug 2016 at 07:58 pm

They inject me intravenously, there are no problems, no stomach problems, no dizziness, and nothing pops up anywhere. The drug is good and helps very quickly)))))

Tatyana June 04, 2016 at 08:39

I had an operation, and I was injected intravenously with ceftriaxone for 3 days. How long can I breastfeed a baby?

Vlad April 18, 2016 at 10:08 pm

After the next intramuscular injection, my wife developed red spots all over her body, severe itching and chills, at first small spots then turned into large lesions, the skin on her legs began to turn blue, we are terrified, what should we do? ? ?

Alesya November 01, 2015 at 11:51 am

intravenous antibiotic is not painful. only unpleasant sensations for the world

Sergey Oct 11, 2015 at 11:47 pm

It hurts a lot when they prick him. The most painful antibiotic, so if you are not too sick yet, think about whether an hour of insomnia is worth one injection.

Danyal Gendugov CBD April 27, 2014 at 05:58 pm

THE DRUG IS EXCEPTIONAL. Thank you very much

aliftin March 30, 2013 at 09:15 pm

Is there ceftriaxone in tablets?

Similar drugs

Antibacterial agents for systemic use.

Antibacterial agents for systemic use. Cephalosporins. Ceftriaxone.

Antimicrobial agents for systemic use.

Antimicrobial agents for systemic use. Beta-lactam antibiotics. III generation cephalosporins.

Antibiotic of the cephalosporin group.

Antibiotic of the cephalosporin group.

Antimicrobial agents for systemic use.

III generation cephalosporin.

Antibiotic of the cephalosporin group.

Antibiotic of the cephalosporin group.

Antimicrobial agents for systemic use. Beta-lactam antibiotics. III generation cephalosporins.

Antimicrobial agents for systemic use. Beta-lactam antibiotics. III generation cephalosporins.

Antibiotic of the cephalosporin group.

Antimicrobial agents for systemic use.

Source: http://www.24farm.ru/preparats/tseftriakson_lekko/