Antibiotic suprax

Posted on by admin

Antibiotic Suprax for children

The antibiotic Suprax for children is produced by Jazira Pharmaceutical Industries, whose head office is located in Saudi Arabia. Suprax belongs to the category of semi-synthetic, broad-spectrum 3rd generation cephalosporin antibiotics.

Table of contents:

The drug contains cefixime tridigrad. For older children, Suprax is available in capsule form (200, 400 ml). In pediatrics, Suprax is widely used for the treatment of sore throat in children under one year of age in 60 ml vials, which contain granules for preparing a suspension (100 ml).

Suprax is a drug of the cephalosporin group, available in the form of tablets and suspensions, suitable for oral administration.

The pharmaceutical industry offers a considerable arsenal of antimicrobial and bactericidal agents for oral administration. When considering the usual methods of administering antibiotics (via injection), the most gentle method for treatment in pediatrics is to administer the drug orally. The parenteral method of taking the medicine is considered the main method of treating ENT diseases. Another advantage of such drugs is the precise dosage of the drug and high peak concentration.

The most important task of pharmacology is the creation of new drugs that reduce the number of doses, not only with a wide spectrum of action, but also with reduced toxicity, which is very important in pediatrics. The use of drugs orally definitely reduces the likelihood of infection propagation, reduces the workload of medical personnel and makes it possible to treat both in a clinic and inpatient setting.

Instructions for use

The antibiotic Suprax for children is prescribed for infectious and inflammatory diseases caused by infectious agents, harmful bacteria that cause otolaryngological infections, which most often manifest themselves in the form of cough and sore throat. Suprax is also effective for diseases of the genitourinary system and gonococcal infections. In cases of problems with the respiratory organs, as well as in the treatment of relapses and chronic infections, Suprax can be used to treat children from the age of six months, both within the clinic and at home.

Suprax compares favorably with its cheaper analogs and is one of the most effective antibiotics for treating children at home from a very early age. It has a light strawberry aroma and is easy to use, well accepted by the body, which is important when treating a child. The antibiotic Suprax is prescribed by the attending physician and is available with a prescription. The exact dosage of the drug is clearly described by the manufacturer in the instructions for the drug. One of the advantages of Suprax is that it can be taken both before and after meals and the effectiveness of the drug is not reduced.

The half-life of Suprax is much longer than that of similar antibiotics; in the case of treating young children, this is an undeniable advantage, since you can take the medicine only once every 24 hours.

How to take as capsules

Antibiotic dosage for children 12 years of age and older, weighing 50 kg or more, the drug is prescribed in the amount of 400 mg in one dose, or 200 mg every 12 hours. The duration of the course of medication depends on the complexity of the disease. As a rule, for gonorrhea without complications, take 400 mg of Suprax once. For more complex streptococcal infections, an antibiotic should be taken for at least 10 days, 200 mg of antibiotic every 12 hours. If the child’s well-being improves, it is better to reduce the dose to 200 mg every 24 hours.

Preparation of the suspension

First of all, you need to shake the contents of the bottle. Measure out the required amount of the drug. Boil 40 ml of water. Cool boiled water to degrees Celsius. Mix the suspension with boiled water thoroughly until the components are combined. Then you should wait 5-7 minutes until the suspension settles. The granules should completely dissolve in water. The prepared suspension must be shaken before use.

How to take as a suspension

The intake of Suprax suspension is calculated based on the formula (8 mg of antibiotic per 1 kg of body) for small children aged 6 months and older. Or 4 mg of the drug 2 times every 24 hours. For children 5-11 years old, the dose of the drug is 6-10 ml of suspension, at the age of 2-4 years - 5 ml, at the age of 6 months. up to 1 year – 2.5-4 ml. at 24 hours. Adults and children over 12 years of age weighing 50 kg or more should take the antibiotic 400 mg once or 200 mg twice a day. The most common duration of drug treatment is 5-10 days. In more severe cases, Suprax is taken for at least 10 days. It is also possible to adjust the dose of the drug if there is deterioration in kidney function and for patients undergoing hemodialysis.

Contraindications of the drug

In general, Suprax is easily tolerated and, with the correct dosage, does not cause complications in children. Long-term treatment with Suprax may lead to dysfunction of the intestinal microflora, manifested by colic, bloating, and diarrhea. This can be easily avoided if you combine taking Suprax with taking medications that contain lactic acid bacteria and normalize intestinal function.

Suprax is contraindicated for people allergic to penicillin and cephalosporin antibiotics.

Allergic reactions are possible, manifested on the skin in the form of redness. When taking Suprax, it is also possible to reduce concentration and reaction speed. It is necessary to stop breastfeeding if you need to take the drug. For diabetics, please note that Suprax contains a small amount of sucrose.

Analogs

A study of the bactericidal activity of cephalosporin antibiotics of the 1st, 2nd and 3rd generations against pneunotropic viruses in bronchopulmonary infections in children showed the highest effectiveness of the 3rd generation cephalosporin. There were no significant differences in the effectiveness of antibiotics for injection and for oral use. This explains the high popularity of the drug Suprax in pediatrics.

Studies of the effectiveness and safety of Cifexime (Suprax) revealed clinical effectiveness in 89% of sick children, which was expressed in an improvement in the child’s condition on average on the 3rd day, a decrease in sputum production, a decrease in cough and signs of sore throat on the 3rd day.

Normalization of functional parameters occurred on the 10th day of treatment. Cefexime has been shown to be quite effective in combating acute inflammatory diseases of the respiratory organs in children in cases of relapse. A convenient dosage form, gentle frequency of administration, and a safe method of treatment without side effects make the drug the most promising antimicrobial agent among its analogues.

Analogues of Suprax are: Cefix, Flamifix, Fixim, Loprax, Ikzim, Pancef, Amoxiclav, Sumamed, Zinnat, Augmentin.

  • The most common analogue of Suprax for the treatment of cough and sore throat in children under one year of age is the bactericidal syrup Pancef. The popularity of Pancef in the antibiotic market is due to the fact that in some regions it is more accessible and cheaper than Suprax. Its main component is the antibiotic cefixime 100 mg per 60 ml.
  • Amoxiclav is prescribed for symptoms of tonsillitis (antibiotic tablets 1000 mg/200 mg, 875 mg/125 mg). Amoxiclav is also offered in the form of a 250 mg suspension in 60 mg tubes. It should be noted that the main active ingredient included in amoxiclav, amoxicillin, has many contraindications for the treatment of children under one year of age.
  • Sumamed is a broad-spectrum antibiotic. Available in the form of a 100 mg powder, which must be diluted in water at room temperature, 0.25 mg capsules and 0.5 g tablets. The main active ingredient of the drug for the treatment of sore throat and other inflammations of the ENT organs in children and adults is azithromycin. The cost of this drug is somewhat cheaper in comparison with analogues, since it has a number of contraindications for the treatment of children under one year of age. The instructions for use of the drug state that if the dosage of the antibiotic is not calculated correctly, the child may experience hearing loss.
  • Augmentin is an antibacterial drug for the temporary treatment of ENT infections, urinary tract infections, sepsis, and osteomyelitis.
  • Zinnat is a drug similar to Suprax. Zinnat is produced in the form of granules, which are diluted in water to obtain a 100 mg suspension. The cost of the drug is somewhat cheaper than its analogues. Zinnat is different in that it is a 2nd generation cephalosporin antibiotic, and accordingly it cannot be a full replacement for Suprax.

The price of Suprax depends on the form of release and mg dosage. The average price of the drug Suprax ranges from 280 to 580 rubles. If Suprax is replaced with a cheaper analogue, you should carefully study the instructions to make sure that the chosen drug has a similar composition and properties. The analogue must be a 3rd generation cephalosparin, the main drug in it must be cefixime. A pharmacist at a pharmacy can tell you the availability of such drugs and correctly calculate their dosage. You should not listen to the advice of ordinary users without medical education.

Source: http://lecheniedetej.ru/preparaty/antibiotiki/supraks.html

Suprax - instructions for use, analogs, reviews and release forms (capsules or tablets 200 mg and 400 mg, suspension or syrup) medications for the treatment of sore throat, pharyngitis and sinusitis in adults, children and pregnancy. Antibiotic composition

In this article you can read the instructions for using the drug Suprax. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Suprax in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of the antibiotic Suprax in the presence of existing structural analogues. Use for the treatment of sore throat, pharyngitis and sinusitis in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Suprax is a 3rd generation semi-synthetic broad-spectrum cephalosporin antibiotic for oral administration. Acts bactericidal. The mechanism of action is due to inhibition of the synthesis of the pathogen's cell membrane. Cefixime is resistant to beta-lactamases produced by most gram-positive and gram-negative bacteria.

In vitro and in clinical practice, Suprax is active against gram-positive and gram-negative bacteria.

Pseudomonas spp., Enterococcus (Streptococcus) serogroup D, Listeria monocytogenes, Staphylococcus spp. are resistant to the drug. (including methicillin-resistant strains), Enterobacter spp., Bacteroides fragilis, Clostridium spp.

Cefixime (in trihydrate form) + excipients.

When taken orally, the bioavailability of Suprax is 40-50%, regardless of food intake. Binding to plasma proteins, mainly albumin, is 65%. About 50% of the dose is excreted unchanged in the urine within 24 hours, about 10% of the dose is excreted in bile.

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

  • pharyngitis;
  • tonsillitis;
  • sinusitis;
  • acute and chronic bronchitis;
  • otitis media;
  • uncomplicated urinary tract infections;
  • uncomplicated gonorrhea.

Capsules 200 mg and 400 mg (tablet forms are not available).

Granules for the preparation of a suspension for oral administration (ideal children's form of the drug, sometimes mistakenly called syrup).

Instructions for use and dosage regimen

For adults and children over 12 years of age weighing more than 50 kg, the daily dose is 400 mg 1 time per day. Duration of treatment: days.

For uncomplicated gonorrhea, 400 mg is prescribed once.

For children under 12 years of age, the drug is prescribed in the form of a suspension at a dose of 8 mg/kg body weight once a day or 4 mg/kg every 12 hours.

For children aged 5-11 years, the daily dose is 6-10 ml of suspension, for children aged 2-4 years - 5 ml, for children aged 6 months to 1 year - 2.5-4 ml.

For infections caused by Streptococcus pyogenes, the course of treatment should be at least 10 days.

In case of impaired renal function (with CC from 21 to 60 ml/min) or in patients on hemodialysis, the daily dose should be reduced by 25%.

With CC ≤20 ml/min or in patients on peritoneal dialysis, the daily dose should be reduced by 2 times.

For patients with impaired renal function with CC less than 60 ml/min, on hemodialysis or peritoneal dialysis, the drug should be prescribed in the form of a suspension.

Rules for preparing the suspension

Turn the bottle over and shake the granules. Add 40 ml of boiled water cooled to room temperature in 2 stages and shake after each addition until a homogeneous suspension is formed. After this, it is necessary to allow the suspension to stand for 5 minutes to ensure complete disintegration of the granules. The prepared suspension should be shaken before use.

  • dry mouth;
  • anorexia;
  • nausea, vomiting;
  • diarrhea;
  • constipation;
  • stomach ache;
  • flatulence;
  • gastrointestinal candidiasis;
  • dysbacteriosis;
  • stomatitis;
  • glossitis;
  • pseudomembranous enterocolitis;
  • leukopenia, thrombocytopenia, neutropenia, hemolytic anemia, pancytopenia, aplastic anemia;
  • dizziness;
  • headache;
  • renal dysfunction;
  • acute renal failure;
  • skin itching;
  • hives;
  • skin hyperemia;
  • eosinophilia;
  • fever;
  • exudative erythema multiforme;
  • toxic epidermal necrolysis;
  • anaphylactic shock;
  • dyspnea;
  • development of hypovitaminosis B.
  • impaired renal function with CC less than 60 ml/min (for capsules);
  • children under 12 years of age (for capsules);
  • hypersensitivity to cephalosporins and penicillins.

Use during pregnancy and breastfeeding

The use of Suprax during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to use Suprax during lactation, breastfeeding should be stopped.

Suprax should be prescribed with caution to children under 6 months of age.

For children under 12 years of age, the drug is prescribed as a suspension at a dose of 8 mg/kg body weight once a day or 4 mg/kg every 12 hours.

For children aged 5-11 years, the daily dose is 6-10 ml of suspension, for children aged 2-4 years - 5 ml, for children aged 6 months to 1 year - 2.5-4 ml.

Long-term use of the drug may disrupt the normal intestinal microflora, which can lead to the growth of Clostridium difficile and cause the development of severe diarrhea and pseudomembranous colitis.

Patients with a history of allergic reactions to penicillins may exhibit increased sensitivity to cephalosporin antibiotics.

During treatment, a positive direct Coombs test and a false positive urine test for glucose are possible.

Impact on the ability to drive vehicles and operate machinery

Patients taking cefixime should be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions, taking into account the side effect profile.

Blockers of tubular secretion (allopurinol, diuretics) delay the excretion of cefixime by the kidneys, which can lead to an increase in the concentration of the drug in the blood plasma.

With the simultaneous use of Suprax and carbamazepine, the concentration of carbamazepine in the blood plasma increases.

Reduces the prothrombin index, enhances the effect of indirect anticoagulants.

Antacids containing magnesium or aluminum hydroxide slow down the absorption of the drug, so the drug should be used 1-2 hours before or 4 hours after taking these medications.

Analogues of the drug Suprax

Structural analogues of the active substance:

Source: http://instrukciya-otzyvy.ru/314-supraks-po-primeneniyu-analogi-kapsuly-tabletki-suspenziya-sirop-angina-faringit-gaymorit.html

Antibiotic suprax

Suprax is a third generation antibiotic that contains the active ingredient cifixin.

Suprax - indications for use

This drug is prescribed and used for:

  • infectious diseases of the respiratory tract (pneumonia, tracheitis, bronchitis, whooping cough, etc.);
  • infectious diseases of the urogenital system;
  • for the treatment of inflammatory processes of the ENT organs (tonsillitis, pharyngitis, otitis, sinusitis, etc.).

The scope of application of suprax is quite wide. This drug is one of the most powerful antibiotics, which is why it is classified as a so-called reserve. Suprax is logical and necessary to use in cases where other, more “gentle” drugs do not have the necessary effect. It is undesirable to use the antibiotic Suprax to begin treatment of the disease, since in the future the body may become accustomed to this drug.

Suprax in the form of a suspension is the most optimal treatment option for sore throat and bronchitis in children. If the attending physician prescribes the correct course of treatment with Suprax, taking into account all contraindications, indications for allergies and tolerability of the drug. With the optimal dosage and course duration, Suprax is very well tolerated by children. In hospitals, acute forms of pneumonia are treated with this drug.

Suprax for otitis is a very effective drug. It quickly penetrates into affected areas, since its maximum concentration in the blood is reached after four hours. This drug lingers in the tissues for a long time. Patients tolerate treatment with this medicine well. All these properties indicate that Suprax is suitable for the treatment of acute otitis media in children.

The antibiotic suprax is widely used for sinusitis; it successfully eliminates the causative agents of the disease. This drug is convenient to use - take the medicine twice a day and the course of treatment is three to six days.

Suprax - release form

The main forms of release of suprax are:

  • capsules that contain 200 mg or 400 mg of active substance;
  • granules;
  • suspension, which, due to its rapid action and pleasant taste, is mainly used in the treatment of children.

It should be remembered that Suprax, like any other drug, is quite individual in its composition, and therefore is not suitable for everyone. Many people are allergic to antibiotics. When treated with Suprax, not everyone experiences positive body reactions to this drug. Therefore, you can hear both positive and negative reviews about this antibiotic.

Suprax side effects and contraindications

There are a number of contraindications for this medicine, as for any other antibiotic.

It is prohibited to take Suprax for categories of people who are allergic to drugs of the penicillin and cephalosporin groups. Suprax should be taken with caution in patients with kidney or liver disease. It is not recommended for women during pregnancy and breastfeeding, as well as for infants under 6 months of age.

Side effects of the drug:

  • for the gastrointestinal tract: dysbacteriosis, jaundice, stomatitis, glossitis, as well as provoking a state of lightheadedness, vomiting, diarrhea, flatulence;
  • for the hematopoietic system: anemia, leukopenia, bleeding;
  • for the central nervous system: the appearance of migraine, dizziness, tinnitus;
  • for the urogenital system: vaginitis;
  • for the urinary system: impaired renal function, interstitial nephritis;
  • various reactions due to an allergy to suprax: the manifestation of itching and redness of the skin, itching in the genital area, an increase in the number of eosinophils in the blood, urticaria, increased body temperature, various diseases of the skin and mucous membrane, anaphylactic shock.

In order to avoid diseases associated with disturbances of the intestinal microflora, as well as the microflora of the mucous membranes of the mouth and vagina, it is necessary to take probiotics (lacidophil, acipol, etc.) simultaneously with suprax.

Copying information is permitted only with a direct and indexed link to the source

Source: http://womanadvice.ru/antibiotik-supraks

Suprax: instructions for use

Before purchasing the antibiotic Suprax, you must carefully read the instructions for use, methods of use and dosage, as well as other useful information on the drug Suprax. On the website “Encyclopedia of Diseases” you will find all the necessary information: instructions for proper use, recommended dosage, contraindications, as well as reviews from patients who have already used this drug.

Suprax is an antibiotic from the group of third-generation cephalosporins, intended for oral administration. This drug is used to treat bacterial infections of various organs, such as infectious and inflammatory diseases of the respiratory tract (pharyngitis, tonsillitis, sinusitis, bronchitis), diseases of the urinary and biliary tract (cystitis, pyelonephritis, cholecystitis), diseases of the skin and soft tissues (phlegmon, abscesses, boils, etc.), as well as diseases such as otitis media, osteomyelitis, endometritis, Lyme disease, gonorrhea of ​​the cervix, urethra.

Composition and release form

Currently, the antibiotic Suprax is available in two varieties, called Suprax and Suprax Solutab. In fact, these two types of the drug differ from each other only in names and forms of release, and there are no more differences between them, since they contain the same active substances, and they also have the same indications, contraindications and rules of use. That is why both Suprax and Suprax Solutab are often combined at the everyday level under one common name “Suprax”. In the further text of the article we will do the same, and by the general name “Suprax” we will mean both varieties of the same drug.

In general, it can be assumed that different names were given to different dosage forms of the same drug for commercial reasons. From the point of view of commercial interests, it is more convenient for manufacturing companies to sell the same drug under different names.

So, Suprax is available in three dosage forms:

• Dispersible tablets (under the commercial name Suprax Solutab);

• Capsules for oral administration (under the commercial name Suprax);

• Granules for the preparation of suspension for oral administration (under the commercial name Suprax).

Dispersible (absorbable) tablets are sold under the name "Suprax Solutab", they are oblong, scored on both sides, pale orange in color and have a strawberry scent. Available in packs of 1, 5, 7 or 10 tablets.

Capsules are produced under the name "Suprax", they are oblong cylinders consisting of a white body and a purple cap. On the surface of the capsules there is the inscription “H808” written in edible ink. Inside the capsules there is a mixture of powder and small granules, colored yellowish-white. Capsules are available in packs of 6 pieces.

Granules for the preparation of an oral suspension are produced under the name “Suprax”; they are small balls, painted white or cream. The finished suspension, obtained after dissolving the granules in water, is white or cream in color and has a sweet strawberry aroma. Granules are produced in dark glass bottles, which are accompanied by a dosing spoon or dosing syringe for measuring the required amount of the finished suspension. The bottles contain 30.3 - 35.0 g of granules, which, when dissolved, give a suspension with an active substance concentration of 100 mg per 5 ml, or 20 mg per 1 ml.

All dosage forms of Suprax contain the same substance as an active component - cefixime. Cefixime is included in the finished medicine not in its pure form, but in the form of a salt - cefixime trihydrate, since this ensures its passage through the aggressive environment of the stomach undestructed, and the release of the active substance in the intestine, from where it is absorbed into the bloodstream.

Each tablet contains 447.7 mg of cefixime trihydrate, and each capsule contains 466 mg, which corresponds to 400 mg of pure cefixime. Accordingly, both Suprax tablets and capsules have the same dosage - 400 mg. Because of this, they are often called Suprax 400 in everyday life. Previously, capsules with a dosage of the active substance of 200 mg were also available for sale, but these are currently not available.

The granules of one bottle contain 1.402 g of cefixime trihydrate, which corresponds to 1.2 g of pure cefixime. This amount of antibiotic allows you to create a concentration of the active substance cefixime in the finished solution of 100 mg per 5 ml (20 mg per 1 ml). The amount of pure cefixime in 5 ml of the finished solution (100 mg) corresponds to 116.83 mg of cefixime trihydrate.

Pharmacological action of Suprax

Suprax is the first antibiotic among 3rd generation cephalosporins that can be taken orally. It is based on cefixime and has a wide spectrum of activity. The bactericidal mechanism of action of the drug is realized by inhibiting the formation of the main component of the cell wall of pathogens. Unlike previous generations of its analogues, Suprax is resistant to beta-lactamases (bacterial enzymes that destroy the antibiotic, causing its action to become ineffective).

According to the instructions, Suprax inhibits the vital activity of gram-positive (various streptococci) and gram-negative (hemophilus and Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Serracia, Citrobacter, gonococci) bacteria, but Pseudomonas aeruginosa, most types of staphylococcus, Enterobacter and Listeria are resistant to it.

The bioavailability of the antibiotic is 40–50%; food intake does not reduce it (as with other oral cephalosporins), but only slightly lengthens the time to reach maximum levels in the blood. Among all previous generations of Suprax analogues for oral administration, it has the longest half-life, thanks to which it can be taken once a day, which is very convenient, for example, for small children.

Suprax penetrates well into the source of infection - into the middle ear cavity, paranasal sinuses, tonsils, lungs, bile ducts.

50% of the unchanged drug is excreted from the body in the urine, making it highly effective in the treatment of urinary tract infections. About 10% of it is excreted in bile.

When taken simultaneously with diuretics, the elimination of the drug slows down, and its high concentration remains in the blood longer.

Suprax, according to reviews, has a slight inhibitory effect on the intestinal microflora compared to its analogues.

Suprax has a detrimental effect on the following types of pathogenic and opportunistic bacteria:

— Moraxella (Branhamella) catarrhalis;

The following types of bacteria are resistant to the action of Suprax:

— Enterococcus (Streptococcus) group D;

The effectiveness of taking Suprax once a day for various diseases, according to studies by clinical pharmacologists in Hungary, is as follows:

• Exacerbation of chronic bronchitis – 72.2%;

• Sinusitis in children – 97.8%;

• Otitis media in children – 96.0%;

• Urinary tract infections – 95.0%.

When taken orally, the bioavailability of cefixime is 40–50%, regardless of food intake, however, the Cmax of cefixime in serum is achieved 0.8 hours faster when taking the drug with food.

When taking the drug in capsule form at a dose of 200 mg, Cmax in serum is achieved after 4 hours and is 2 mcg/ml, when taken at a dose of 400 mg - 3.5 mcg/ml. When taking the drug in the form of a suspension at a dose of 200 mg, Cmax in serum is achieved after 4 hours and is 2.8 mcg/ml, when taken at a dose of 400 mg - 4.4 mcg/ml. Binding to plasma proteins, mainly albumin, is 65%.

About 50% of the dose is excreted unchanged in the urine within 24 hours, about 10% of the dose is excreted in bile. T1/2 depends on the dose and is 3–4 hours.

In patients with impaired renal function, with a creatinine Cl of 20-40 ml/min, T1/2 increases to 6.4 hours, with a creatinine Cl of 5-10 ml/min - up to 11.5 hours.

Indications for use of Suprax

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

- pharyngitis, tonsillitis, sinusitis;

- acute and chronic bronchitis;

- uncomplicated urinary tract infections;

Suprax dosage

For adults and children over 12 years of age weighing more than 50 kg, the drug is prescribed at a dose of 400 mg 1 time per day.

For uncomplicated gonorrhea, 400 mg is prescribed once.

The average duration of treatment is days.

For infections caused by Streptococcus pyogenes, the course of treatment should be at least 10 days.

For patients with impaired renal function with CC less than 60 ml/min on hemodialysis or peritoneal dialysis, the drug should be prescribed in the form of an oral suspension.

Oral suspension

For children aged 6 months to 12 years, the drug is prescribed at a dose of 8 mg/kg body weight 1 time/day or 4 mg/kg every 12 hours.

For children aged 5-11 years, the daily dose is 6-10 ml of suspension, for children aged 2-4 years - 5 ml, for children aged from 6 months to 1 year - 2.5-4 ml.

For adults and children over 12 years of age weighing more than 50 kg, the drug is prescribed at a dose of 400 mg 1 time / day or 200 mg 2 times / day.

The average duration of treatment is days.

For infections caused by Streptococcus pyogenes, the course of treatment should be at least 10 days.

In case of impaired renal function (with CCml/min) or in patients on hemodialysis, the daily dose should be reduced by 25%.

With CC ≤20 ml/min or in patients on peritoneal dialysis, the daily dose should be reduced by 2 times.

Rules for preparing the suspension

Turn the bottle over and shake its contents. Add 40 ml of boiled water cooled to room temperature in 2 stages and shake after each addition until a homogeneous suspension is formed. After this, it is necessary to allow the suspension to stand for 5 minutes to ensure complete dissolution of the granules.

The prepared suspension should be shaken before use.

Side effects of Suprax

Allergic reactions: urticaria, skin flushing, pruritus, eosinophilia, fever, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), anaphylactic shock, reactions resembling serum sickness.

From the nervous system: headache, dizziness, tinnitus, convulsions.

From the digestive system: dry mouth, anorexia, nausea, vomiting, diarrhea, constipation, flatulence, abdominal pain, dysbacteriosis, liver dysfunction, cholestasis, cholestatic jaundice, candidiasis, stomatitis, glossitis, pseudomembranous enterocolitis.

From the urinary system: interstitial nephritis, impaired renal function, acute renal failure.

From the reproductive system: vaginitis, itching of the genitals.

Laboratory indicators: increased activity of liver transaminases and alkaline phosphatase, hyperbilirubinemia, increased urea nitrogen, hypercreatininemia, increased prothrombin time.

Other: candidomycosis, shortness of breath.

Symptoms: increased manifestations of the described side effects, especially from the digestive system, with the exception of allergic reactions.

Treatment: gastric lavage; carry out symptomatic and supportive therapy, which, if necessary, includes the use of antihistamines, corticosteroids, epinephrine, norepinephrine, dopamine, oxygen therapy, transfusion of infusion solutions, mechanical ventilation. Cefixime is not removed in large quantities from the circulating blood by hemo- or peritoneal dialysis.

Contraindications to the use of Suprax

Suprax is contraindicated for use if a person has the following conditions or diseases:

• Individual hypersensitivity or allergic reactions to antibiotics of the cephalosporin and/or penicillin groups;

• Individual hypersensitivity or allergic reactions to cefixime or any other auxiliary components of the drugs;

• Chronic renal failure in children under 18 years of age (for Suprax Solutab dispersible tablets);

• Impaired kidney function, in which creatinine clearance (CC) according to the Rehberg test is less than 60 ml/min (for capsules);

• Body weight of a child or adult is less than 25 kg (for Suprax Solutab dispersible tablets);

• Children under 12 years of age (for capsules);

• Children under six months of age (for granules for the preparation of a suspension for oral administration);

• Hereditary fructose intolerance, glucose and galactose malabsorption, sucrase and isomaltase deficiency (for granules for oral suspension).

In addition, Suprax in any dosage form (dispersible tablets, capsules and suspension) should be used with caution and under supervision if a person has the following conditions or diseases:

• Old age (over 65 years);

• Chronic renal failure;

• Pseudomembranous colitis suffered in the past.

special instructions

Tablets, suspension and capsules can be taken regardless of meals.

People on hemodialysis or suffering from renal impairment with a creatinine clearance (CC) of less than 60 ml/min should take Suprax in the form of a suspension or dispersible tablets. Suprax capsules are prohibited for use by people on hemodialysis, peritoneal dialysis, or those suffering from renal impairment with CC less than 60 ml/min.

With long-term use of Suprax (longer than 15 days), intestinal dysbiosis may develop and, as a result, excessive growth of Clostridium difficile, which provokes severe antibiotic-associated diarrhea and pseudomembranous colitis. If diarrhea and signs of colitis develop, you should stop taking Suprax and consult a doctor. Typically, mild forms of antibiotic-associated diarrhea go away after Suprax is discontinued. But if the diarrhea is severe, then, in addition to discontinuing the drug, corrective treatment is prescribed, for example, taking Vancomycin 250 mg 4 times a day. It should be remembered that for diarrhea and pseudomembranous colitis, you should not use medications that inhibit the passage of contents through the intestines (Loperamide, Imodium).

People who have suffered in the past from allergic reactions to penicillin antibiotics are highly likely to be allergic to Suprax. If a person experiences Lyell's syndrome, Stevens-Johnson syndrome or DRESS syndrome as an allergic reaction, they should immediately stop taking Suprax and consult a doctor as soon as possible.

In addition, you should stop taking Suprax and immediately go to the hospital if acute renal failure or hemolytic anemia develops, since isolated cases of death from hemolytic anemia caused by other cephalosporin antibiotics have been described.

If Suprax provoked hemolytic anemia, then in the future you should generally refrain from using cephalosporin antibiotics, since the body may again react to any drug of this class by developing anemia. You should also not start taking Suprax if a person has previously had an episode of hemolytic anemia in response to the use of cephalosporin antibiotics.

During the period of use of Suprax, a positive direct Coombs reaction and a false positive urine reaction to glucose are possible. It is better not to take these tests while taking Suprax, as they are not accurate.

People suffering from diabetes should remember that the suspension contains sucrose in the amount of 15 g per 20 ml.

When using Suprax in combination with Polymyxin B, Colistin, loop diuretics (Furosemide, Torasemide, Ethacrynic acid, etc.) and aminoglycoside antibiotics (Gentamicin, Tobramycin, Amikacin, etc.), renal function should be monitored.

After long-term use of Suprax, the state of the hematopoietic system should be monitored.

During pregnancy, Suprax can be used only if the expected benefit to the woman outweighs all possible risks to the fetus. In practice, cephalosporin antibiotics are often prescribed to pregnant women because they are relatively safe compared to other antibacterial drugs.

Prescription of Suprax for children

Children under 12 years of age can only be given Suprax in the form of tablets or suspension. Suprax capsules are suitable for use only for children over 12 years of age with a body weight of at least 50 kg. This means that the capsules cannot be taken by children, even if they are over 12 years old but weigh less than 50 kg.

Suprax tablets are approved for use in children weighing at least 25 kg. This means that, regardless of the child’s age, if his weight is 25 kg or more, he can be given Suprax Solutab in the form of dispersible tablets.

Suprax suspension can be used for children from the age of 6 months. This dosage form is optimal for children under 12 years of age. Therefore, doctors recommend giving the drug to children in the form of a suspension, preferring it to tablets and capsules.

Children under 6 months of age should be given Suprax in the form of a suspension only under the supervision of a physician, unless it is possible to replace this antibiotic with another that is safer for the baby.

Drug interactions

Simultaneous use with tubular secretion blockers (Allopurinol, Probenecid), diuretics (Furosemide, Ethacrynic acid, Tobrasemide, etc.), penicillin antibiotics (Amoxicillin, Ampicillin, Phenylbutazone, etc.) leads to an increase in the concentration of Suprax in the blood, which can provoke an overdose the last one.

Suprax increases the concentration of Carbamazepine in the blood with the simultaneous use of these drugs.

Suprax reduces the value of the prothrombin index, thereby enhancing the effects of indirect anticoagulants (for example, Warfarin). Therefore, Suprax in combination with anticoagulants should be used with caution, constantly monitoring the INR or PTI to prevent the development of bleeding.

Antacids containing aluminum or magnesium hydroxides (for example, Maalox, Almagel) must be taken 4 hours before or 1 to 2 hours after taking Suprax, as they slow down and worsen the absorption of the antibiotic into the bloodstream. And Suprax, accordingly, should be taken 1 - 2 hours before or 4 hours after antacid medications.

Taking Suprax in combination with drugs that have a toxic effect on the kidneys (Polymyxin B, Colistin, aminoglycoside antibiotics (Gentamicin, Tobramycin, etc.), Viomycin, etc.), as well as with diuretics (Furosemide, Ethacrynic acid, etc.), increases the risk of developing kidney problems.

Suprax may reduce the effectiveness of oral contraceptives. Therefore, during the period of use and for a week after completion of Suprax therapy, in addition to oral contraceptives, barrier methods of pregnancy protection (female condom, male condom, caps, etc.) should be used.

Suprax's analogs

Currently, Suprax has two types of analogues on the domestic pharmaceutical market - these are synonymous drugs and, in fact, analogues.

Synonyms for Suprax are medications that also contain cefixime as an active ingredient. Actually, analogues are drugs that do not contain the same active substance as Suprax, but have the most similar spectrum of therapeutic action. This means that analogues of Suprax are antibiotics belonging to the cephalosporin group (to which Suprax itself belongs).

The following drugs are synonyms for Suprax:

• Ixim Lupine (powder for the preparation of suspension for oral administration);

• Pancef (granules for the preparation of suspension for oral administration, tablets);

• Ceforal Solutab (dispersible tablets).

The following antibiotics are analogues of Suprax:

• Azaran (powder for solution for injection);

• Axon (powder for solution for injection);

• Bakperazone (powder for solution for injection);

• Bestum (powder for the preparation of solution for injection);

• Betasporin (powder for solution for injection);

• Biotriaxone (powder for solution for injection);

• Broadsafe-S (powder for solution for injection);

• Vicef (powder for solution for injection);

• Dardum (powder for solution for injection);

• Intrataxim (powder for solution for injection);

• Ificef (powder for solution for injection);

• Kefotex (powder for solution for injection);

• Clafobrine (powder for solution for injection);

• Klaforan (powder for solution for injection);

• Lendacin (powder for solution for injection and infusion);

• Lifaxon (powder for solution for injection);

• Liforan (powder for solution for injection);

• Lorazidim (powder for solution for injection);

• Loraxone (powder for solution for injection);

• Medakson (powder for solution for injection);

• Medocef (powder for the preparation of solution for injection);

• Movigip (powder for solution for injection);

• Movoperiz (powder for solution for injection);

• Operaz (powder for solution for injection);

• Orzid (powder for solution for injection);

• Oritax (powder for solution for injection);

• Oritaxim (powder for solution for injection);

• Oframax (powder for solution for injection);

• Pactocef (powder for solution for injection);

• Resibelakta (powder for solution for injection);

• Roceferin (powder for solution for injection);

• Rocephin (powder for solution for injection and infusion);

• Stericef (powder for solution for injection);

• Sulzoncef (powder for solution for injection);

• Sulmover (powder for the preparation of solution for injection);

• Sulperazon (powder for solution for injection);

• Sulperacef (powder for solution for injection);

• Sulcef (powder for solution for injection);

• Sulcefazone (powder for solution for injection);

• Tax-o-bid (powder for solution for injection);

• Talcef (powder for solution for injection);

• Tarcefoxime (powder for solution for injection);

• Terzef (powder for solution for injection);

• Tizim (powder for solution for injection);

• Torocef (powder for solution for injection);

• Triaxone (powder for solution for injection);

• Fortazim (powder for solution for injection);

• Fortoferin (powder for solution for injection);

• Fortum (powder for solution for injection);

• Chizon (powder for solution for injection);

• Cebanex (powder for solution for injection);

• Cedex (capsules and powder for the preparation of suspension for oral administration);

• Ceperon J (powder for solution for injection);

• Cetax (powder for solution for injection);

• Cephabol (powder for solution for injection);

• Cefaxone (powder for solution for injection);

• Cefantral (powder for solution for injection);

• Cefatrin (powder for solution for injection);

• Cefzide (powder for solution for injection);

• Cefzoxime J (powder for solution for injection);

• Cephobid (powder for solution for injection);

• Cefogram (powder for solution for injection);

• Cefoperabol (powder for solution for injection);

• Cefoperazone (powder for solution for injection);

• Cefoperus (powder for solution for injection);

• Cefosin (powder for solution for injection);

• Cefotaxime (powder for solution for injection);

• Cefpar and Cefpar SV (powder for solution for injection);

• Cefson (powder for solution for injection);

• Ceftazidime (powder for solution for injection);

• Ceftidine (powder for solution for injection);

• Ceftriabole (powder for solution for injection);

• Ceftriaxone (powder for solution for injection).

Suprax's analogues are cheaper

The following analogue drugs are cheaper than Suprax:

• Klaforan – price per bottle of powder is 160 – 200 rubles;

• Sulperazon – price per bottle of powder is 300 – 400 rubles;

• Fortum – price per bottle 200 – 600 rubles;

• Cefaxon – price per bottle 160 – 250 rubles;

• Cefantral – price per bottle 80 – 120 rubles;

• Cephobid – price per bottle 300 – 350 rubles;

• Cefosin – price per bottle 40 – 60 rubles;

• Cefotaxime produced in Russia, Belarus, Ukraine, China or India, price per bottle is 20 – 40 rubles;

• Ceftazidime – price per bottle 75 – 160 rubles;

• Ceftriaxone produced in Russia, Belarus, Ukraine, China or India, price per bottle is 20 – 40 rubles.

Reviews of Suprax

Most of the reviews about Suprax (from 70 to 80%) are positive, due to its high effectiveness for the treatment of severe, protracted infectious diseases of the respiratory and genitourinary systems, as well as ENT organs in children and adults.

The reviews note that the antibiotic helped with tracheitis, bronchitis, otitis media, sinusitis, purulent tonsillitis, pyelonephritis, pharyngitis and a number of other infections of the respiratory, urinary and biliary tract, as well as the genitals in children and adults. Suprax turned out to be effective in severe and long-term cases of these diseases, when other drugs (including other antibiotics) and treatment methods were ineffective.

In addition to its high effectiveness, according to the people who used it, the antibiotic also has other positive characteristics: the possibility of use in young children and ease of use. In addition, the reviews separately note as an advantage of Suprax that it can be taken orally, which allows one to avoid painful injections of other antibiotics that are effective in treating bacterial infections of the respiratory and genitourinary organs.

The disadvantages of Suprax include its high cost, the risk of developing severe allergies, as well as the short shelf life of the finished diluted suspension.

Negative reviews about Suprax are due either to its ineffectiveness in any particular case, or to the development of a severe allergic reaction to the drug.

I've been taking it for three days, but there are no results yet. But they say that for a severe cold, the effect begins 72 hours after the first dose, i.e. for 4 days. Waiting for tomorrow. If it doesn’t help after 4-5 days, you need to change it (consult a doctor).

He never helped us, yesterday they called an ambulance again... They took us to the hospital... Diagnosis: bronchitis, laryngitis and pneumonia are in question...

Good medicine. This is the second time it has helped my daughter. The first time was appointed two years ago. Valid throughout the day. You just need to take Linex or Normobact at the same time, otherwise it destroys the intestinal microflora. Well, the treatment should be comprehensive: tonsilgon (drops), tantum verde (spray). This time they also gave us a nasal spray - Izfra (also an antibiotic). This is me for those who like self-medication, or for those who are unlucky with their doctor. The saddest thing is that all good antibiotics are imported.

Olya Samuta (Chepeleva)

My child has bronchitis, the child is 4 years old! These tablets were prescribed 1/2 once a day. The temperature was 38.7, so I think maybe I should have gone to the hospital or it should be due to bronchitis.

Good product, it helps.

After dental prosthetics, a fistula very similar to a boil formed on the gum. It existed for more than a year, I couldn’t get it out. I tried a lot of remedies, but only SUPRAX (6 pills) helped me with this problem. Glory to SUPRAX!

They prescribed it for my daughter. I was shocked by the price when I bought it. On the third day of admission, I was shocked that the child’s stool was formed but WHITE. The temperature barely began to subside on the 5th day. Now I am asking for another medication to be prescribed instead. In general, azithromycin always helps the whole family with all illnesses; the temperature disappears on the 2nd day.

A friend’s boy fell ill with bronchitis in the fall and took Suprax. Now he has hemolytic anemia, platelets drop to zero, and requires a bone marrow transplant.

I don’t know on what day we had an improvement, but after taking 5 days of antibiotics, it all went away.

It was prescribed for cystitis, but I didn’t see much effect at all - I took it for a week and a half, I just stopped, and all the symptoms returned again. Then I had to drink more Monural and Monurel. Apparently, suprax does not help everyone.

Antibiotic Astellas Suprax Solutab. Aggressive spam on women's forums Suprax Solutab completely excludes the purchase of this antibiotic in principle, and recalling the experience of taking it last year, when as a result time was lost and cystitis almost passed into the chronic stage (E. coli managed to spread to the ureter and rise higher - to kidneys!), and evokes a strong desire to warn those who are now being forced to buy it from buying it!

Used during pregnancy as prescribed by a urologist. The drug perfectly helped to cope with the cause of cystitis - Escherichia coli bacteria - in just 7 days. In addition, I did not have any side effects from it - no stomach upset, no nausea (although in principle I often get this from antibiotics).

The pediatrician prescribed it to us, it helped well, after a couple of days the child was jumping around as if he wasn’t sick at all, but before that he wasn’t at all. But our allergies after it were NOT small. It covered everything, I walked around itching, and for another two weeks after that the rash went away...

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature of 15° to 25°C.

Shelf life: 3 years.

The prepared suspension should be used within 14 days from the date of preparation, subject to storage conditions (15-25°C).

Conditions for dispensing from pharmacies: the drug is available with a prescription.

We would like to draw special attention to the fact that the description of the antibiotic Suprax is presented for informational purposes only! To obtain more accurate and detailed information about the drug Suprax, we ask you to refer exclusively to the manufacturer’s annotation! Do not self-medicate under any circumstances! You should definitely consult a doctor before starting to use the drug!

Source: http://vlanamed.com/supraks-instruktsiya-po-primeneniyu/