ACC in powder instructions

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How to dissolve and drink ACC powder: instructions for use, reviews of the drug in bags

To get rid of isolated and chronic cases of diseases of the bronchopulmonary system, accompanied by the release of difficult to separate sputum, medications are used.

Table of contents:

One of the most effective and widely used is ACC, produced in the following forms for oral use:

  • tablets soluble in water (so-called effervescent);
  • granular powder;
  • syrup suspension.

To achieve the greatest effect, you must strictly follow the document “ACC: instructions for use.” The powder dissolves quickly in water or other liquid and allows you to get rid of phlegm in a short time. Due to this, this is the form most often prescribed to patients.

Composition of ACC in sachets

The main active ingredient that has a beneficial effect on the bronchopulmonary system is acetylcysteine. This component is a mucolytic agent that has an expectorant effect, thinning even thick sputum.

Additional components are the following substances (according to the instructions for use):

  • sucrose, which gives the granules a sweetish taste;
  • ascorbic acid, which acts as an antioxidant;
  • saccharin, a sugar substitute that adds sweetness;
  • flavoring, most often orange, for a pleasant smell and taste.

The drug contains sucrose, which is important for people with diabetes to know.

Mechanism of action

ACC powder is prescribed for wet cough. The main causes of this type of cough are phlegm accumulated in the lungs and bronchi.

Due to the coughing mechanism, the body tries to get rid of mucus, which is often very thick. Liquefaction of sputum promotes its rapid removal and relief from coughing.

The medicinal effect occurs due to the main component acetylcysteine. Acetylcysteine ​​molecules break down the bonds between mucopolysaccharide chains, making mucus less viscous and easier to expectorate. The instructions for using ACC powder emphasize the fact that the drug has a positive effect in cases where purulent inclusions are present in the mucus discharge.

ACC powder is beneficial for patients suffering from chronic diseases of the lungs and bronchi. Acetylcysteine ​​activates the synthesis of substances that are components of the body's antioxidant system, which protect cells from damage during inflammatory processes. Due to this property, ACC is recommended to be taken for preventive purposes.

Absorption of the active substance occurs instantly. Over a period of one to three hours, the maximum levels of the presence of ACC components in the blood vessels occur. The instructions for using the powder state that inactive metabolites are excreted by the kidneys.

Method of use for cough

The drug is recommended for use in all cases of diseases associated with the appearance of viscous sputum in the lungs and bronchi. These diseases include the following:

In any form of these diseases, a positive effect is observed from the drug ACC (powder). How to take the medicine in each specific case is prescribed by the doctor, indicating the dose and frequency of administration.

In any case, the instructions for using ACC granules state that you need to dissolve the contents in a glass of hot water and drink. Depending on the disease and age of the patient, the number of doses per day and the duration of use of the medicine are determined. Usually one sachet of medicine is consumed per dose.

Instructions for use

For any course of disease of the bronchopulmonary system, ACC powder is used. How to take the drug is explained in the instructions supplied with the drug. The choice of dose is based on the patient’s body weight and age, the severity of the disease, and the presence of other physiological disorders in the body.

The doctor will always prescribe the exact dose of the ACC drug to the patient. Instructions for use in sachets have special instructions and may differ from other forms of release.

How to breed?

The primary question for a person taking medicine is how to dilute ACC? The powder must be used strictly as prescribed; improper use of the substance can lead to unexpected consequences.

In this case, you should not be afraid of any unforeseen situations, but you must adhere to some recommendations.

The contents of the sachet must be dissolved in liquid before use and drunk immediately. In this way, the best effect from the ACC drug will be achieved. The powder, which contains ascorbic acid, has a pleasant taste.

In some cases, the medicine can be taken 2 hours after diluting the powder in water.

It is important to take the right amount of water to dissolve the powder. The recommended dose is considered to be a whole glass, that is, approximately 200 ml. This volume is suitable for both children and adults. As is traditionally noted in the instructions for use for mucolytics, additional fluid will only have a positive effect on the body, it will quickly thin out sputum and speed up the release of mucus.

What water to dissolve in?

Competently following the instructions will help you quickly get rid of a cough using ACC powder. What water to dissolve in - hot or cold - is one of the important points in the treatment process.

Adults and children are prescribed ACC in powder. The instructions for use state that it is best to dilute it in hot water. Children cannot always drink a drink at a high temperature, so in such cases it is permissible to use warm water.

In what water to dissolve the ACC powder also depends on the conditions of administration. If you are on the road and there is no hot water at hand, then you should not skip taking the drug - you can dissolve it in a liquid at room temperature.

How to use?

A convenient form of release is ACC in bags. How to take the medicine is indicated by its instructions. You should drink the diluted drink immediately after eating.

The duration of use in standard cases of colds is from five to seven days. If the patient suffers from chronic forms of bronchopulmonary diseases, then ACC sachets are prescribed for a longer period.

Although the instructions for use are not indicated, with prolonged treatment the effectiveness of acetylcysteine ​​decreases. For this reason, long-term monotherapy with ACC powder is not used.

How many times a day should you drink?

The result of treatment and recovery time depend on how often the patient takes ACC. The powder, the method of application of which is determined by the age and body weight of the patient, helps to quickly get rid of sputum.

Typically, the following age groups of patients are distinguished:

  • children from two to six years old;
  • children aged six to fourteen;
  • children over 14 years old and adults.

The answer to the question: how many times a day should you drink ACC? The answer to the question also depends on the type and complexity of the disease. The powder in packages can have different dosages - 100, 200 and 600 mg. The frequency of administration also depends on this.

  1. The first age group of children (from 2 to 6 years old) is prescribed 1 sachet of ACC granules at a dosage of 100 mg 2 or 3 times a day. This corresponds to a daily dose of acetylcysteine ​​of 200–300 mg.
  2. Children from six to fourteen years old, in accordance with the instructions for use, need to take 300–400 mg of the active substance per day. To do this, drink 1 sachet of medication with a dosage of 100 mg three times a day or 200 mg sachet twice a day.
  3. For treatment, adults and children over 14 years of age are recommended to consume 400 to 600 mg of acetylcysteine ​​per day. The number of doses of the drug depends on the chosen dosage - 100 mg, 200 mg or 600 mg.

If you have a sachet of ACC with a dosage of 600 mg, then it is enough to take the medicine once a day. A dosage of 200 mg is taken 2 or 3 times. Packets labeled 100 mg are taken two at a time - twice or three times a day.

Important information for patients

Here is some important information that people taking ACC need to know. What water to dissolve in (hot or cold) is described above. But it is also worth considering the type of drinking glass. You cannot use metal or rubber, only glass or ceramic mugs and glasses.

More and more often, doctors recommend ACC to their patients. The doctor will tell you how to take and drink the powder in each specific case, but you should adhere to the following recommendations:

  1. If the patient suffers from irritation of the gastric mucosa, then it is better to take granulated ACC rather than effervescent tablets. The powder, how to drink and dilute it, is described above.
  2. Be sure to read the accompanying papers for the ACC drug. The instructions for use of the powder have prescribed contraindications. For example, the drug should not be used by people with allergic reactions to acetylcysteine.
  3. People with stomach and duodenal ulcers should not use ACC for treatment.
  4. The instructions for use of the granules do not recommend taking the substance to women during pregnancy and breastfeeding.
  5. You cannot combine taking the drug and antitussives.

It is not recommended to drink solutions immediately before bedtime. The best time to take the last daily dose is before 18:00.

Acetylcysteine ​​is incompatible with tetracycline and penicillin antibiotics and reduces their absorption. Therefore, if patients are prescribed antibacterial drugs, then it is worth distinguishing between taking ACC powder and antibiotics with a break of at least two hours.

People suffering from chronic diseases of the bronchopulmonary system, pulmonary or heart failure may be prescribed ACC. The powder, the use of which in prescribed doses, guarantees easier breathing, as well as a reduction in the risk of infectious inflammation in the bronchi and lungs.

What kind of reviews does the drug receive?

Doctors are increasingly prescribing ACC for patients with various diseases of the bronchopulmonary system. In most cases, the powder receives only positive reviews.

A large number of patients note the fact that a positive effect is observed almost from the first day of use. The drug is well tolerated. Consumers also write that the substance has the following advantages:

  • liquefaction of sputum in 3–4 days even in severe cases of the disease;
  • Possibility to accept children and adults;
  • pleasant taste sensations, which is important for children.

Patients testify that the drug allows you to get rid of an annoying cough caused by viscous sputum in a matter of days. The granular form is especially in demand, allowing you to prepare a medicinal drink in a matter of moments.

Granules are convenient to use on the road, at work, or on a business trip. Only one sachet of ACC is needed per dose. The sachets and instructions for use are in a cardboard box, which is convenient to take with you.

ACC powder 200 mg

There are various forms of ACC release. Instructions for use of the powder describe dosages of 100 mg, 200 mg and 600 mg. But the greatest demand for adults is for sachets labeled 200 mg ACC. It is convenient to take cough powder at this dose three times a day at a time, since adult patients are usually prescribed 600 mg of acetylcysteine ​​per day.

ACC granules 100 mg for children

ACC powder in granules 100 mg for children is ideal for children and corresponds to a single dose. The main thing is to strictly follow the doctor’s recommendations - how many times a day to drink ACC. The powder dissolves quickly and tastes very pleasant, which is important for kids.

Useful video

For useful information about the treatment of bronchitis, watch this video:

Conclusion

  1. ACC powder helps to quickly get rid of cough and other diseases of the bronchi and lungs.
  2. Proper use will allow you to get rid of mucus in the lungs in a short time, liquefy it and remove it from the body.
  3. To take the drug correctly, you need to understand how to dissolve ACC. This is indicated in the instructions for use: just pour the contents of the package into hot water, stir and drink immediately.
  4. Usually one packet is enough for a single dose; the main thing is to choose the right dosage - 100, 200 or 600 mg.
  5. In most cases of use, a positive effect is observed within a few days of use.

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Source: http://www.pulmonologiya.com/preparaty/kashel/poroshok-acc.html

Powder "Acc 100" for children: instructions for use

A child’s cough worries any mother and makes her want to immediately help the baby. To combat this symptom, mucolytic agents are often used to help make viscous sputum more liquid. Among such drugs, a medicine from the Sandoz company called ACC 100 is very popular. Can children take it and how does the child’s body react to this drug? In what dose and how many times should ACC be given to a child with a cough?

Release form

ACC 100 is produced in three versions:

  • Effervescent tablets. They are packaged in tubes (one contains 20 pieces) and are round, flat tablets that have a blackberry scent and are white in color. After dissolving such a tablet, a clear, colorless liquid is formed that smells like blackberries. There may be a slight smell of sulfur.
  • Granules from which a solution is prepared (it is given to the child to drink). They are white and uniform, smell like orange and are packaged in 3 gram bags. One package contains 20 sachets. After stirring the granules in water, an orange drink is obtained.
  • Syrup. The content of the active substance in this form of ACC is 100 mg per 5 ml of syrup. The medicine is a slightly viscous, colorless, transparent liquid with a cherry odor. It is placed in a dark glass bottle with a volume of 100 ml.

Compound

The active ingredient in the drug ACC 100 is acetylcysteine. Its content, as can be understood from the name of the medication, is 100 mg in each package or in one effervescent tablet. Additional ingredients are:

  • Effervescent tablets contain sodium carbonate, sodium saccharinate, ascorbic acid, sodium citrate, citric acid, lactose, sodium bicarbonate, mannitol, blackberry flavor.
  • The granules contain saccharin, vitamin C, sucrose, orange flavor.
  • Syrup contains Na saccharinate, water, Na benzoate, Na hydroxide, disodium edetate, methyl parahydroxybenzoate, Na carmellose, cherry flavor.

Operating principle

Acetylcysteine ​​contained in ACC 100 has a mucolytic effect. Such a compound directly affects the mucus that is produced in the respiratory tract, as a result of which the rheological characteristics of the mucus change. The drug destroys the bonds of mucopolysaccharides present in the secretion, which leads to a decrease in the viscosity of sputum. It is noted that the medicine actively dilutes mucus, even when there is pus in the bronchi.

Acetylcysteine ​​also has an antioxidant effect. This substance activates the production of glutathione and neutralizes radicals arising during oxidative reactions. As a result, the drug activates the protection of airway cells and reduces the severity of inflammation.

Promotional video for the drug ACC:

Indications

The reason to prescribe ACC 100 is the presence of excessively viscous secretion in the bronchi, which needs to be liquefied and removed from the respiratory tract.

The medicine is in demand for the following problems:

  • Laryngitis.
  • Bronchitis.
  • Pneumonia.
  • Laryngotracheitis.
  • Bronchiolitis.
  • Chronic pulmonary diseases, including those with obstruction.
  • Otitis media
  • Sinusitis.
  • Bronchiectasis.
  • Lung abscess.
  • Cystic fibrosis.

You may be interested in watching the episode of Dr. Komarovsky’s program, which touches on such a pressing topic as cough in children:

At what age is it allowed to take it?

The use of ACC 100 is recommended for children who are already 2 years old. Forms with a higher dosage are prescribed to older children - ACC 200 from the age of 6, and ACC long from the age of 14.

Contraindications

Taking ACC 100 is not recommended:

  • If you are intolerant to acetylcysteine ​​or another component of the drug, for example, lactose in effervescent tablets.
  • If blood is found in the sputum.
  • With glucose-galactose malabsorption.
  • When bleeding is detected in the lung.
  • With a peptic ulcer that has worsened.
  • With a deficiency of sucrase or lactase (for the form in which sucrose or lactose is present).

The doctor should prescribe ACC 100 for bronchial asthma, kidney pathology, adrenal gland diseases, diabetes mellitus, high blood pressure or liver diseases with special attention.

Side effects

  • Taking ACC 100 may cause an allergic reaction such as itching, hives, skin rashes or swelling. Occasionally, the drug provokes anaphylaxis.
  • The child's respiratory tract may respond to ACC 100 treatment with the appearance of shortness of breath. If the baby has bronchial asthma, the medicine can cause bronchospasm.
  • The digestive system of some children “responds” to the use of ACC 100 with a dyspeptic disorder, for example, loose stools, abdominal pain or heartburn.
  • Rare side effects from acetylcysteine ​​treatment include tinnitus, fever, headache, and bleeding.

Instructions for use and dosage

ACC 100 is recommended to be taken after meals. The required number of tablets is dissolved in one glass of water and then drunk immediately. It is recommended to prepare the medicinal solution only in glass containers. If the drug is diluted with water, it can be stored in liquid form for no longer than 2 hours.

To dissolve the granules, you can use not only water, but also non-hot tea or juice. The syrup is dosed using the syringe or measuring cup included in the package. It is not recommended to give the medicine later than 6 pm so as not to disturb the child’s sleep. For a greater therapeutic effect, it is recommended to give children more to drink.

The dose of the drug is determined based on the age of the small patient:

  • If the child is not yet 6 years old, then he is given from 200 to 300 mg of acetylcysteine ​​per day. This amount is divided into 2 doses, so a single dosage will be 1-1.5 tablets or 1-1.5 packets of granules. If the drug is given in syrup, then a single dose at the age of 2-5 years will be 5 or 7.5 ml.
  • For children over 6 years of age up to 14 years of age, the daily amount of acetylcysteine ​​for a therapeutic effect is mg. Since the drug is taken twice a day, a single dose will be mg, which corresponds to 1.5-2 effervescent tablets ACC 100, 7.5-10 ml of syrup or 1.5-2 packets of ACC 100 granules. It turns out that from the age of six it is more convenient use ACC 200.
  • A child 14 years of age and older is given from 400 to 600 mg of acetylcysteine ​​per day. The drug is taken 1 to 3 times a day, so ACC 200 and ACC Long are more in demand.

The duration of treatment is determined by the doctor individually, but acute pathology is often treated within 5 or 7 days.

Overdose

If a child takes too high a dose of ACC, it will cause nausea, diarrhea, or vomiting. To help in such a situation, symptomatic therapy is used.

Interaction with other drugs

  • ACC 100 granules or tablets should not be mixed in a glass with any other medications.
  • If a child is given activated carbon or another sorbent, the effectiveness of ACC 100 treatment will decrease.
  • The simultaneous use of ACC 100 and antitussives is prohibited, since after suppression of the cough reflex, the mucolytic effect of acetylcysteine ​​will provoke stagnation of sputum.
  • By adding bronchodilators to ACC 100 treatment, the effectiveness of therapy will increase.
  • ACC 100 may interfere with the antimicrobial action of some antibiotics, such as penicillins or cephalosporins. It is necessary to wait at least 2 hours between taking such medications.
  • If you give the patient ACC 100 and any vasodilating agents, the blood vessels will dilate more.

Terms of sale

To buy ACC 100 at a pharmacy, you do not need a doctor's prescription. The average price for a pack of effervescent tablets or syrup is 240 rubles, and for a pack of 20 sachets you need to pay about 120 rubles.

Storage conditions and shelf life

The storage temperature of tablet form and granules should not exceed +25°C. The tube is kept in a dry place and the tablets are tightly closed after each removal. The shelf life of this form is 3 years.

ACC syrup should be stored away from sunlight and moisture. From the date of release, a closed bottle can be stored for 2 years, and after opening, the medicine should be used within 18 days. ACC 100 granules have a shelf life of 4 years.

Reviews

The drug ACC 100 receives mostly good reviews from parents. Mothers who have treated coughs with this medicine in their children note that the drug is quite effective, and side effects are rarely detected. They confirm that taking ACC 100 facilitated the removal of mucus from the respiratory tract and accelerated the healing process. According to mothers, most children like the taste of the drink made from ACC 100.

Analogs

ACC 100 can be replaced by analogues that have the same active ingredient, for example:

  • Fluimucil. This medicine is produced in an oral solution (contains 20 or 40 mg of acetylcysteine ​​per 1 ml of the drug), in a solution for injections and inhalations, in granules (1 package contains 200 mg of acetylcysteine) and in the form of effervescent tablets with a dosage of the active substance of 600 mg.
  • Acetylcysteine. This domestic drug is produced in effervescent tablets containing 200 mg of the active substance, as well as in powder from which a solution for oral administration is prepared (1 package may contain 100 or 200 mg of acetylcysteine).
  • Acestine. The product is produced in tablets and effervescent tablets of 200 and 600 mg of acetylcysteine.
  • N-AC-Ratiopharm. The medicine is presented in effervescent tablets of 200 or 600 mg of the active substance, as well as sachets with powder from which a solution containing acetylcysteine ​​is prepared in a dosage of 100, 200 or 600 mg.

In addition, instead of ACC 100, other drugs that have a mucolytic effect can be given. These medications include those containing ambroxol or carbocisteine.

The mechanism of action of ACC is clearly shown in the advertisement of the drug.

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Source: http://www.o-krohe.ru/otharkivayushchie-preparaty/poroshok-acc/

ACC powder - instructions for use

Instruction contents:

Composition of azza powder

Active substance azza

Excipients in ace

Indications for use of azza powder

Contraindications for azza powder

  • hypersensitivity to acetylcysteine ​​or a component of the drug
  • renal failure
  • liver failure
  • children up to 6 years old
  • period of pregnancy and lactation
  • acetylcysteine ​​nemese drug componentine asa zhogary sezimtaldyk
  • buyrek kyzmetinin
  • Bauer kizmetinin zhetkiliksizdigi
  • 6 zhaska deyingi balalar
  • beetle lactation case

Side effects of azza powder

  • allergic reactions (itching, urticaria, skin rash, bronchospasm) - tachycardia
  • arterial hypotension
  • headache
  • fever
  • stomatitis, abdominal pain, diarrhea, vomiting, heartburn and nausea
  • shortness of breath, bronchospasm, mainly in patients with increased reactivity of the bronchial system associated with bronchial asthma
  • bleeding and hemorrhage partially associated with hypersensitivity reactions
  • anaphylactic reactions, up to anaphylactic shock
  • allergies
  • tachycardia
  • arterial hypotension
  • bass aur
  • Kyzba
  • stomatitis, irritation, diarrhea, sore throat, urticaria
  • entigu, kobіne bronchial demicpesimen bálánysty bronchialdií zhuje reaktílígí zhogárylágán emdelushilerde bronchtín túyílui
  • burners sezіmtaldyk reactionlarmen іshіnar baylanysty kan ketuler zhane kan құyylular
  • anaphylactic shock action anaphylactic reaction

Special instructions for use

Pregnancy and lactation

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Darilik shut the kolik kuraldaryn not the same qauіptі mechanism derdі baskar kabiletіné ekpal this erekshelіkteri

Dosage and method of administration

Adults and teenagers aged 14 years and older

Children and teenagers from 6 to 14 years old

Eresekter zhane 14 zhastan bastap zhane odan ulken zhastagy zhasospirimder

Balalar zhane 6 zhastan 14 zhaska deyingi zhasospirimder

Drug interactions

Overdose of ace in powder

Pharmacological properties

Pharmacokinetics

Pharmacodynamics

Acetylcysteine ​​helps increase glutathione synthesis, which is important for the detoxification of toxic substances. This explains its antidote effect in paracetamol poisoning. When used prophylactically, it has a protective effect on the frequency and severity of exacerbations of bacterial infections, which was found in patients with chronic bronchitis and cystic fibrosis.

Acetylcysteine ​​glutathione synthesis is burnt in the mucous membranes of the stomach, resulting in the removal of waste products. Bul paracetamolmen ulangand onyn u karsy aserіnіn bar ekendigіn tussindiredi. Ony aldyn alu ushіn қoldanganda ol bakteriyalyk zhukpalardyn orshu zhiіlіgі men auyrlyғyna katysty korganysh aser beredi, ol sozylmaly bronchitis and cystic fibrosis bar naukastarda anaktal yes.

Source: http://acc.farmed.kz/instrukcija/poroshok/

Krasnoyarsk medical portal Krasgmu.net

Instructions for the drug ACC 200: description of the drug, annotation, in what doses to take it, composition, contraindications and side effects.

Tradename

International nonproprietary name

Dosage form

Powder for solution for oral administration 200 mg

Composition of the drug ACC 200

1 sachet (bag) with 3 g of powder contains

active substance – acetylcysteine ​​200 mg

excipients: ascorbic acid (vitamin C), saccharin, sucrose, orange flavor.

Description of the drug ACC 200

Fine, homogeneous, white or yellowish powder with an orange odor.

The resulting solution: colorless, slightly opalescent, with the smell of orange.

Pharmacotherapeutic group

Expectorants. Mucolytics.

ATC code R05 CB01

Pharmacological properties

Pharmacokinetics

After oral administration, acetylcysteine ​​(ACC 200) is rapidly absorbed from the gastrointestinal tract (GIT) and metabolized in the liver into cysteine, a pharmacologically active metabolite, as well as into diacetylcysteine, cystine and various mixed disulfides.

Due to the high first pass effect through the liver, the bioavailability of acetylcysteine ​​is very low (approximately 10%).

In humans, maximum plasma concentrations are reached after 1-3 hours. The maximum plasma concentration of the cysteine ​​metabolite is about 2 µmol/l. The binding of acetylcysteine ​​to plasma protein is approximately 50%.

Acetylcysteine ​​is excreted through the kidneys almost exclusively in the form of inactive metabolites (inorganic sulfates, diacetylcysteine).

The half-life in plasma is approximately 1 hour and is mainly determined by hepatic biotransformation. Therefore, impaired liver function leads to prolonged plasma elimination half-lives of up to 8 hours.

Pharmacodynamics

Acetylcysteine ​​is a derivative of the amino acid cysteine. Acetylcysteine ​​has secretolytic and secretomotor effects in the respiratory tract. It breaks disulfide bonds between mucopolysaccharide chains and has a depolymerizing effect on DNA chains (in purulent sputum). Thanks to these mechanisms, the viscosity of sputum decreases.

An alternative mechanism of acetylcysteine ​​is based on the ability of its reactive sulfhydryl group to bind chemical radicals and thereby neutralize them.

Acetylcysteine ​​helps increase glutathione synthesis, which is important for the detoxification of toxic substances. This explains its antidote effect in paracetamol poisoning.

When used prophylactically, it has a protective effect on the frequency and severity of exacerbations of bacterial infections, which was found in patients with chronic bronchitis and cystic fibrosis.

Indications for use ACC 200

Mucolytic therapy of acute and chronic bronchopulmonary diseases accompanied by impaired secretion and transport of sputum.

Directions for use and dosage

ACC® 200 is taken only in the form of a prepared solution, after meals.

Adults and teenagers aged 14 years and older

1 sachet of powder 2-3 times a day (corresponds to mg of acetylcysteine ​​per day).

Children and teenagers from 6 to 14 years old

1 sachet of powder 2 times a day (corresponds to 400 mg of acetylcysteine ​​per day).

Children over 6 years of age

1 sachet of powder 3 times a day (corresponds to 600 mg of acetylcysteine ​​per day).

For children under 6 years of age, ACC® junior cough syrup is recommended.

The duration of treatment depends on the type and severity of the disease and should be determined by the attending physician.

In the case of chronic bronchitis and cystic fibrosis, long-term treatment should be carried out to prevent infection.

The powder is dissolved in a glass of boiled water and taken after meals.

Side effects on ACC 200

- rarely (³ 0.1% - < 1%): stomatitis, diarrhea, vomiting, heartburn and nausea, headache, tinnitus; bleeding, partly associated with hypersensitivity reactions; decreased platelet aggregation

- very rarely (<0.01%): allergic reactions - itching, urticaria, skin rash, bronchiolospasm, tachycardia and arterial hypotension.

Reports regarding bronchiolospasm primarily concerned patients with increased bronchial system reactivity associated with bronchial asthma.

Contraindications to the drug ACC 200

- hypersensitivity to acetylcysteine ​​or any other component of the drug

Drug interactions

The simultaneous use of acetylcysteine ​​and antitussives can cause dangerous secretory stagnation due to a decrease in the cough reflex. For this reason, this combination therapy option must be based on a particularly accurate diagnosis.

Tetracycline chloride should be administered separately and at least two hours apart.

Reports regarding inactivation of antibiotics (semisynthetic penicillins, tetracyclines, cephalosporins and aminoglycosides) resulting from concomitant use of acetylcysteine ​​or other mucolytic drugs are based solely on laboratory experiments in which the relevant substances were directly mixed. However, for safety reasons, oral antibiotics should be administered separately at least two hours apart.

In cases of simultaneous administration of nitroglycerin (glycerol trinitrate) with acetylcysteine, an increase in its vasodilatory effect and inhibitory effect on platelet aggregation was observed. The clinical significance of these data has not yet been established.

special instructions

The secretolytic effect of ACC® is supported by sufficient fluid intake.

Caution should be exercised when prescribing ACC to patients with a history of bronchial asthma or peptic ulcer disease.

Pregnancy and lactation

The use of ACC is not recommended, because There is no experience of use during pregnancy and lactation.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

The drug does not affect the ability to concentrate.

Overdose

Release form and packaging

ACC® 200 is available in sachets/bags of 3 g; No. 20, 50 or 100 sachets in a cardboard box along with enclosed instructions for use.

Storage conditions

Store at a temperature not exceeding +30°C.

Keep out of the reach of children!

Shelf life

Do not use after the expiration date stated on the packaging.

Vacation conditions

Manufacturer

Salutas Pharma GmbH

D-39179, Barleben, Germany

Hexal AG, Germany Industrialstrasse 25

Holzkirchen, Germany

Salutas Pharma GmbH

D-39179, Barleben, Germany

Hexal AG, Germany Industriestraβe 25 DHolzkirchen, Germany

Source: http://krasgmu.net/publ/acc_200_poroshok_dlja_prigotovlenija_rastvora_dlja_priema_vnutr_instrukcija_opisanie/

ACC 100, 200 powder - instructions for use

Registration number: P N015474/01

Trade name of the drug: ACC®

International nonproprietary name: acetylcysteine.

Dosage form: granules for the preparation of solution for oral administration (orange).

1 sachet contains:

  • active ingredient: acetylcysteine ​​- 100.0/200.0 mg;
  • excipients: sucrose 2829.5/2717.0 mg; ascorbic acid -12.5/25.0 mg; saccharin - 8.0/8.0 mg; orange flavoring - 50.0/50.0 mg.

Description: homogeneous white granules without agglomerates with an orange smell.

Pharmacotherapeutic group: mucolytic agent.

Acetylcysteine ​​is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates the discharge of sputum due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum.

It has an antioxidant effect based on the ability of its reactive sulfhydryl groups (SH groups) to bind to oxidative radicals and thus neutralize them. In addition, acetylcysteine ​​promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine ​​increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.

Absorption is high. Rapidly metabolized in the liver to form a pharmacologically active metabolite - cysteine, as well as diacetylcysteine; cystine and mixed disulfides. Bioavailability after oral administration is 10% (due to the presence of a pronounced “first pass” effect through the liver). The time to reach the maximum concentration (Cmax) in the blood plasma is 1-3 hours. The connection with blood plasma proteins is 50%. It is excreted primarily by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). The half-life (T1/2) is about 1 hour, impaired liver function leads to an extension of T1/2 to 8 hours. Penetrates the placental barrier. There are no data on the ability of acetylcysteine ​​to penetrate the blood-brain barrier and be excreted in breast milk.

Respiratory diseases accompanied by the formation of viscous, difficult to separate sputum:

Acute and chronic sinusitis, inflammation of the middle ear (otitis media).

  • hypersensitivity to acetylcysteine ​​or other components of the drug;
  • peptic ulcer of the stomach and duodenum in the acute stage;
  • hemoptysis, pulmonary hemorrhage;
  • sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose deficiency;
  • pregnancy;
  • breastfeeding period;
  • children under 2 years of age (for this dosage form).

history of gastric and duodenal ulcers, arterial hypertension, bronchial asthma, obstructive bronchitis, liver and/or renal failure, histamine intolerance (long-term use of the drug should be avoided, since acetylcysteine ​​affects the metabolism of histamine and can lead to signs of intolerance , such as headache, vasomotor rhinitis, itching), varicose veins of the esophagus, diseases of the adrenal glands.

Use during pregnancy and breastfeeding

Data on the use of acetylcysteine ​​during pregnancy and breastfeeding are limited, therefore the use of the drug during pregnancy is contraindicated. If it is necessary to use the drug during breastfeeding, the issue of stopping it should be decided.

The granules should be dissolved in water, juice or iced tea and taken after meals. Additional fluid intake enhances the mucolytic effect of the drug.

For short-term colds, the course duration is 5-7 days. For long-term illnesses, the course of therapy is determined by the attending physician. For chronic bronchitis and cystic fibrosis, the drug should be taken for a longer period of time to achieve a preventive effect against infections. In the absence of other prescriptions, it is recommended to adhere to the following dosages:

  • adults and adolescents over 14 years of age: 2 sachets of ACC® 100 mg or 1 sachet of ACC® 200 mg 2-3 times a day (mg. per day);
  • children from 6 to 14 years: 1 sachet 3 times a day or 2 sachets 2 times a day ACC® 100 mg (mg per day). ACC® 200 mg should be taken 3 times a day, 1/2 sachet or 2 times a day, 1 sachet (mg per day);
  • children from 2 to 6 years old: 1 sachet of ACC® 100 mg or 1/2 sachet of ACC® 200 mg 2-3 times a day (mg per day).
  • children over 6 years old: 2 sachets of ACC® 100 mg or 1 sachet of ACC® 200 mg 3 times a day (600 mg per day);
  • children from 2 to 6 years: 1 sachet of ACC® 100 mg or 1/2 sachet of ACC® 200 mg 4 times a day (400 mg per day);
  • patients weighing > 30 kg: if necessary, the dose can be increased to 800 mg.

According to the World Health Organization (WHO), adverse effects are classified according to their frequency as follows: very common (> 1/10), common (> 1/100, <1/10), uncommon (> 1/1000, < 1/100), rare (>1/10000, <1/1000) and very rare (<1/10000); frequency unknown (the frequency of events cannot be determined from the available data).

uncommon: skin itching, rash, exanthema, urticaria, angioedema, decreased blood pressure, tachycardia;

very rare: anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome,

toxic epidermal necrolysis (Lyell's syndrome).

From the respiratory system:

rarely: shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).

From the gastrointestinal tract:

uncommon: stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, dyspepsia.

From the senses:

uncommon: tinnitus.

very rarely: headache, fever, isolated reports of bleeding due to a hypersensitivity reaction, decreased platelet aggregation.

Acetylcysteine ​​when taken in doses of 500 mg/kg/day does not cause signs and symptoms of overdose. In case of an erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed.

Interaction with other drugs

With the simultaneous use of acetylcysteine ​​and antitussives, sputum stagnation may occur due to suppression of the cough reflex.

When used simultaneously with oral antibiotics (penicillins, tetracyclines, cephalosporins, etc.), they may interact with the thiol group of acetylcysteine, which can lead to a decrease in their antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine ​​should be at least 2 hours (except for cefixime and loracarbef):

Concomitant use with vasodilating agents and nitroglycerin may lead to increased vasodilatory effects.

When treating patients with diabetes, it is necessary to take into account that the drug contains sucrose.

Instructions for patients with diabetes mellitus:

  • 1 sachet of ACC® 100 mg corresponds to 0.24 XE.
  • 1 sachet of ACC® 200 mg corresponds to 0.23 XE.

When working with the drug, you must use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

Cases of severe allergic reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell's syndrome) have been very rarely reported with the use of acetylcysteine.

If changes occur in the skin and mucous membranes, you should immediately consult a doctor and stop taking the drug.

You should not take the drug immediately before bedtime (it is recommended to take the drug before 18.00).

Impact on the ability to drive vehicles and machinery

There is no data on the negative impact of the drug ACC® in recommended doses on the ability to drive vehicles and perform other activities that require concentration and speed of psychomotor reactions.

Special precautions when disposing of unused medicinal product There is no need for special precautions when destroying unused ACC® drug.

3 g of granules per bag made of a combined material (aluminum foil/paper/polyethylene). 20 and 50 sachets per cardboard box along with instructions for use.

At a temperature not higher than 25 °C.

Keep out of the reach of children.

Do not use after expiration date.

Sandoz d.d., Verovshkova 57, 1000 Ljubljana, Slovenia; Manufactured by: Lindopharm GmbH, Neustrasse 82, Hilden, Germany. Consumer complaints should be sent to Sandoz CJSC:

125315, Moscow, Leningradsky Prospekt, 72, bldg. 3.; telephone: ; Fax: .

Source: http://med2c.ru/%D0%B0%D1%86%D1%%D0%BF%D0%BE%D1%80%D0%BE%D1%88%D0%BE%D0%BA- %D0%B8%D0%BD%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%86%D0%B8%D1%8F/

ACC powder: instructions for use

The drug ACC is a drug that has a mucolytic effect and is intended for the treatment of a variety of diseases of the respiratory system. Available in granular form. The granules are intended for further dissolution in water and drinking.

Release form and composition

The active substance is acetylcysteine. The granules have a homogeneous consistency without lumps with an orange aroma. Each packet of granules contains 200 or 100 mg of acetylcysteine. In addition to the active substance, auxiliary components have been added to the composition: saccharin, ascorbic acid, sucrose and orange flavoring. A cardboard package may contain 50 or 20 disposable sachets, each of which is made of three-layer material. The package contains detailed instructions.

Indications for use

ACC should be used for the following painful conditions:

  • formation of difficult to separate sputum of viscous consistency;
  • obstructive bronchitis;
  • bronchiectasis;
  • laryngotracheitis;
  • bronchial asthma;
  • cystic fibrosis;
  • pneumonia;
  • in the treatment of chronic and acute sinusitis;
  • bronchiolitis;
  • otitis media;
  • other diseases of the respiratory system.

Contraindications

The ban on taking the ACC drug applies to nursing and pregnant women, children under two years of age, and patients with hypersensitivity to any component of this drug. Increased caution is required when prescribing ACC to people with varicose veins in the esophagus, hemoptysis, bronchial asthma (due to a possible complication in the form of bronchospasm), failure of the kidneys or adrenal glands, liver, or peptic ulcer. In pregnant women, taking ACC is possible only in extreme cases, when the benefit outweighs the likelihood of developing undesirable consequences.

Directions for use and dosage

ACC in adolescents, starting from the age of 14 years and in adults, is used according to the scheme. In the treatment of diseases of the respiratory system, you should take 1 packet containing acetylcysteine ​​200 mg or 2 packets with 100 mg of the drug 3 times over 24 hours. The total dose of acetylcysteine ​​ranges from 400 to 600 mg per day. It is divided into several doses after consultation with a doctor.

Children from 6 to 14 years of age should consume 300–400 mg of the drug per day. The dose is divided into 3 or 2 times at approximately equal intervals.

Children from 2 to 5 years old are prescribed ACC at a dose of 100 mg twice a day.

A different treatment regimen is performed in the treatment of cystic fibrosis. From the age of six, three doses of 200 mg are required. Children 2–5 years old should take 100 mg of the drug four times in 24 hours. Sometimes it is necessary to increase the daily dose to 800 mg in patients who weigh more than 30 kg.

Diseases that last a short time require treatment with ACC for about 6 to 7 days. In the case of treatment of cystic fibrosis or chronic problems with the respiratory system, a long course is required, selected by the doctor strictly individually.

How to dilute ACC powder?

The drug ACC is prescribed strictly after meals. The granules in the bag must be dissolved in a cool liquid (tea, water, juice). Parallel intake of liquids significantly increases the activity of acetylcysteine.

Side effects

During therapy, the following unpleasant complications may occur:

  • headache;
  • noise in ears;
  • the appearance of inflammatory elements in the oral cavity;
  • nausea or heartburn;
  • stool disorder;
  • tachycardia;
  • decreased blood pressure;
  • Isolated complaints of allergic complications were recorded. The most common occurrence is bronchospasm, which is usually recorded in patients with increased bronchial reactivity. Possible itching or rash;
  • development of bleeding (extremely rare).

special instructions

Patients with diabetes mellitus should take into account the fact that a packet of ACC with a dosage of 200 mg corresponds to 0.23 VE, and with a dosage of 100 mg - 0.24 VE. The granules contain sucrose. When feeding and lactation, ACC is prescribed under strict medical supervision in extreme cases.

It is prohibited to use ACC with substances that have an antitussive effect. Possible stagnation of mucus in the bronchi. You need to know that nitroglycerin taken simultaneously with acetylcysteine ​​will enhance its vasodilating effect. ACC is incompatible with drugs related to antibiotics. This is especially true for cephalosporins, penicillins, erythromycin, amphotericin B and tetracycline. It is also impossible to take ACC with proteolytic enzymes. ACC granules dissolve only in glass containers. Do not use metal utensils. In the presence of bronchial asthma or obstructive bronchitis, acetylcysteine ​​is prescribed with periodic monitoring of bronchial patency.

Analogues of ACC

Preparations containing acetylcysteine: Acestad tablets and granules, Acestal S, ACC hot drink, ACC tablets, Fluimucil and many others.

Drugs with a similar therapeutic effect include Ambroxol, Sudafred, Fluifort, Lazolvan, Bromhexine.

Terms and conditions of storage

ACC can be stored in rooms with a room temperature of about 25 degrees. The shelf life in original packaging is 4 years. The drug should be hidden from children. Dispensing from pharmacies is permitted without a prescription.

ACC powder price

ACC granules for the preparation of oral solution 100 mg, 20 pcs. — from 113 rub.

ACC granules for the preparation of oral solution 200 mg, 20 pcs. — from 121 rub.

Source: http://bezboleznej.ru/acc-poroshok

ACC 200 (powder): instructions for use

Dosage form

Powder for solution for oral administration 200 mg

Compound

1 sachet contains 3 g of powder

active substance: acetylcysteine ​​200 mg

excipients: sucrose, ascorbic acid, saccharin, dry orange flavor 1:1000 Sotteri 289**

(**- Orange flavor essence 11.1%, dextrose anhydride 82.7%, lactose 6.2%)

Description

Powder from white to yellowish color, with partial agglomeration of particles, with the smell of orange.

The reconstituted solution is colorless, transparent or slightly opalescent.

Pharmacotherapeutic group

Drugs for the treatment of diseases of the respiratory system. Medicines to relieve symptoms of colds and coughs. Expectorants. Mucolytics. Acetylcysteine

ATX code R05 CB01

Pharmacological properties

After oral administration, acetylcysteine ​​is rapidly absorbed from the gastrointestinal tract (GIT) and metabolized in the liver to cysteine, a pharmacologically active metabolite, as well as diacetylcysteine, cystine and various mixed disulfides.

Due to the high first pass effect through the liver, the bioavailability of acetylcysteine ​​is very low (approximately 10%).

In humans, maximum plasma concentrations are reached after 1-3 hours. The maximum plasma concentration of the cysteine ​​metabolite is about 2 µmol/l. The binding of acetylcysteine ​​to plasma protein is approximately 50%.

Acetylcysteine ​​is excreted through the kidneys almost exclusively in the form of inactive metabolites (inorganic sulfates, diacetylcysteine).

The half-life in plasma is approximately 1 hour and is mainly determined by hepatic biotransformation. Therefore, impaired liver function leads to a prolongation of the plasma half-life of up to 8 hours.

Acetylcysteine ​​is a derivative of the amino acid cysteine. Acetylcysteine ​​has secretolytic and secretomotor effects in the respiratory tract. It breaks disulfide bonds between mucopolysaccharide chains and has a depolymerizing effect on DNA chains (with purulent sputum). Thanks to these mechanisms, the viscosity of sputum decreases.

An alternative mechanism of acetylcysteine ​​is based on the ability of its reactive sulfhydryl group to bind chemical radicals and thereby neutralize them.

Acetylcysteine ​​helps increase glutathione synthesis, which is important for the detoxification of toxic substances. This explains its antidote effect in paracetamol poisoning.

When used prophylactically, it has a protective effect on the frequency and severity of exacerbations of bacterial infections, which was found in patients with chronic bronchitis and cystic fibrosis.

Indications for use

— secretolytic therapy for acute and chronic diseases of the bronchi and lungs, accompanied by impaired formation and elimination of sputum.

Directions for use and dosage

ACC® 200 is taken only in the form of a prepared solution, after meals.

Adults and teenagers aged 14 years and older

1 sachet of powder 2-3 times a day (corresponds to mg of acetylcysteine ​​per day).

Children and teenagers from 6 to 14 years old

1 sachet of powder 2 times a day (corresponds to 400 mg of acetylcysteine ​​per day).

The duration of treatment depends on the type and severity of the disease and should be determined by the attending physician.

The powder is dissolved in a glass of boiled water and taken after meals.

For children under 6 years of age, other forms of ACC are recommended: ACC® junior, powder for oral solution, 20 mg/ml, ACC®100, effervescent tablets, 100 mg, ACC®200, effervescent tablets, 200 mg.

Side effects

Uncommon (≥1/1000, <1/100)

- allergic reactions (itching, urticaria, skin rash, bronchospasm, Quincke's edema, exanthema)

- stomatitis, abdominal pain, diarrhea, vomiting, heartburn, nausea

Rarely (≥1/10000, <1/1000)

- shortness of breath, bronchospasm, mainly in patients with increased reactivity of the bronchial system associated with bronchial asthma

Very rare (< 1/10,000)

- bleeding and hemorrhage, partly associated with hypersensitivity reactions

- anaphylactic reactions, up to anaphylactic shock

- Stevens-Johnson syndrome, Lyell's syndrome

Various studies have shown a decrease in platelet aggregation under the influence of acetylcysteine. At present, the clinical significance of this phenomenon has not been established.

Contraindications

- hypersensitivity to any component of the drug

- peptic ulcer of the stomach and duodenum in the acute stage

- hemoptysis, pulmonary hemorrhage

- bronchial asthma in the acute stage

- children up to 6 years old

- intolerance to fructose, galactose, deficiency of saccharin-isomaltose, lactose, glucose-galactose malabsorption syndrome

With caution: varicose veins of the esophagus, bronchial asthma, diseases of the adrenal glands, liver and/or kidney failure, arterial hypertension.

Drug interactions

The simultaneous use of acetylcysteine ​​and antitussives can cause dangerous secretory stagnation due to a decrease in the cough reflex. For this reason, this combination therapy option must be based on a particularly accurate diagnosis.

To achieve the best therapeutic effect, oral antibiotics (penicillins, tetracyclines and aminoglycosides) should be administered separately, with a two-hour time interval. This does not apply to cefixime and loracarbef.

The use of activated carbon in large doses can weaken the effect of acetylcysteine.

The simultaneous use of nitroglycerin and acetylcysteine ​​should be carried out under the supervision of a physician, as the vasodilatory effect and inhibitory effect on platelet aggregation may be enhanced.

Acetylcysteine ​​may interfere with the colorimetric assay for the determination of salicylates.

Acetylcysteine ​​may interfere with the results of ketone bodies in urine tests.

special instructions

If changes occur in the skin and mucous membranes, the patient should immediately stop taking acetylcysteine ​​and consult a doctor.

In patients with bronchial asthma and obstructive bronchitis, ACC® 200 should be prescribed with caution under systematic monitoring of bronchial conduction due to the risk of developing bronchospasm.

The use of the drug ACC® 200 can lead to dilution of sputum in the bronchi and a slight increase in its volume. If the cough reflex is insufficient, postural drainage or aspiration is used.

Patients with histamine intolerance should take ACC® 200 in short courses, due to the effect on the metabolism of histamine itself and the possible appearance of intolerance symptoms (for example, headache, runny nose, itching).

1 sachet contains 2.7 g of sucrose. This should be taken into account when prescribing ACC® 200 to patients with diabetes mellitus.

Pregnancy and lactation

The use of ACC® 200 during pregnancy and lactation is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus and child.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Overdose

Symptoms: nausea, vomiting, diarrhea; children have a risk of hypersecretion.

Release form and packaging

3 g per sachet. 20 or 50 sachets along with instructions for medical use in the state and Russian languages ​​are placed in a cardboard pack

Storage conditions

Store at a temperature not exceeding 30°C.

Keep out of the reach of children!

Shelf life

Do not use after the expiration date.

Conditions for dispensing from pharmacies

Manufacturer

Lindopharm GmbH., Germany

Neustraße 82, DHilden, Germany

You should consult your doctor and read the instructions before use.

Source: http://tab.103.kz/atsts-200-poroshok-instruktsiya/