Acc instructions in powder

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ACC 100, 200 powder - instructions for use

Registration number: P N015474/01

Trade name of the drug: ACC®

International nonproprietary name: acetylcysteine.

Dosage form: granules for the preparation of solution for oral administration (orange).

Table of contents:

1 sachet contains:

  • active ingredient: acetylcysteine ​​- 100.0/200.0 mg;
  • excipients: sucrose 2829.5/2717.0 mg; ascorbic acid -12.5/25.0 mg; saccharin - 8.0/8.0 mg; orange flavoring - 50.0/50.0 mg.

Description: homogeneous white granules without agglomerates with an orange smell.

Pharmacotherapeutic group: mucolytic agent.

Acetylcysteine ​​is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates the discharge of sputum due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum.

It has an antioxidant effect based on the ability of its reactive sulfhydryl groups (SH groups) to bind to oxidative radicals and thus neutralize them. In addition, acetylcysteine ​​promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine ​​increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.

Absorption is high. Rapidly metabolized in the liver to form a pharmacologically active metabolite - cysteine, as well as diacetylcysteine; cystine and mixed disulfides. Bioavailability after oral administration is 10% (due to the presence of a pronounced “first pass” effect through the liver). The time to reach the maximum concentration (Cmax) in the blood plasma is 1-3 hours. The connection with blood plasma proteins is 50%. It is excreted primarily by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). The half-life (T1/2) is about 1 hour, impaired liver function leads to an extension of T1/2 to 8 hours. Penetrates the placental barrier. There are no data on the ability of acetylcysteine ​​to penetrate the blood-brain barrier and be excreted in breast milk.

Respiratory diseases accompanied by the formation of viscous, difficult to separate sputum:

Acute and chronic sinusitis, inflammation of the middle ear (otitis media).

  • hypersensitivity to acetylcysteine ​​or other components of the drug;
  • peptic ulcer of the stomach and duodenum in the acute stage;
  • hemoptysis, pulmonary hemorrhage;
  • sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose deficiency;
  • pregnancy;
  • breastfeeding period;
  • children under 2 years of age (for this dosage form).

history of gastric and duodenal ulcers, arterial hypertension, bronchial asthma, obstructive bronchitis, liver and/or renal failure, histamine intolerance (long-term use of the drug should be avoided, since acetylcysteine ​​affects the metabolism of histamine and can lead to signs of intolerance , such as headache, vasomotor rhinitis, itching), varicose veins of the esophagus, diseases of the adrenal glands.

Use during pregnancy and breastfeeding

Data on the use of acetylcysteine ​​during pregnancy and breastfeeding are limited, therefore the use of the drug during pregnancy is contraindicated. If it is necessary to use the drug during breastfeeding, the issue of stopping it should be decided.

The granules should be dissolved in water, juice or iced tea and taken after meals. Additional fluid intake enhances the mucolytic effect of the drug.

For short-term colds, the course duration is 5-7 days. For long-term illnesses, the course of therapy is determined by the attending physician. For chronic bronchitis and cystic fibrosis, the drug should be taken for a longer period of time to achieve a preventive effect against infections. In the absence of other prescriptions, it is recommended to adhere to the following dosages:

  • adults and adolescents over 14 years of age: 2 sachets of ACC® 100 mg or 1 sachet of ACC® 200 mg 2-3 times a day (mg. per day);
  • children from 6 to 14 years: 1 sachet 3 times a day or 2 sachets 2 times a day ACC® 100 mg (mg per day). ACC® 200 mg should be taken 3 times a day, 1/2 sachet or 2 times a day, 1 sachet (mg per day);
  • children from 2 to 6 years old: 1 sachet of ACC® 100 mg or 1/2 sachet of ACC® 200 mg 2-3 times a day (mg per day).
  • children over 6 years old: 2 sachets of ACC® 100 mg or 1 sachet of ACC® 200 mg 3 times a day (600 mg per day);
  • children from 2 to 6 years: 1 sachet of ACC® 100 mg or 1/2 sachet of ACC® 200 mg 4 times a day (400 mg per day);
  • patients weighing > 30 kg: if necessary, the dose can be increased to 800 mg.

According to the World Health Organization (WHO), adverse effects are classified according to their frequency as follows: very common (> 1/10), common (> 1/100, <1/10), uncommon (> 1/1000, < 1/100), rare (>1/10000, <1/1000) and very rare (<1/10000); frequency unknown (the frequency of events cannot be determined from the available data).

uncommon: skin itching, rash, exanthema, urticaria, angioedema, decreased blood pressure, tachycardia;

very rare: anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome,

toxic epidermal necrolysis (Lyell's syndrome).

From the respiratory system:

rarely: shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).

From the gastrointestinal tract:

uncommon: stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, dyspepsia.

From the senses:

uncommon: tinnitus.

very rarely: headache, fever, isolated reports of bleeding due to a hypersensitivity reaction, decreased platelet aggregation.

Acetylcysteine ​​when taken in doses of 500 mg/kg/day does not cause signs and symptoms of overdose. In case of an erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed.

Interaction with other drugs

With the simultaneous use of acetylcysteine ​​and antitussives, sputum stagnation may occur due to suppression of the cough reflex.

When used simultaneously with oral antibiotics (penicillins, tetracyclines, cephalosporins, etc.), they may interact with the thiol group of acetylcysteine, which can lead to a decrease in their antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine ​​should be at least 2 hours (except for cefixime and loracarbef):

Concomitant use with vasodilating agents and nitroglycerin may lead to increased vasodilatory effects.

When treating patients with diabetes, it is necessary to take into account that the drug contains sucrose.

Instructions for patients with diabetes mellitus:

  • 1 sachet of ACC® 100 mg corresponds to 0.24 XE.
  • 1 sachet of ACC® 200 mg corresponds to 0.23 XE.

When working with the drug, you must use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

Cases of severe allergic reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell's syndrome) have been very rarely reported with the use of acetylcysteine.

If changes occur in the skin and mucous membranes, you should immediately consult a doctor and stop taking the drug.

You should not take the drug immediately before bedtime (it is recommended to take the drug before 18.00).

Impact on the ability to drive vehicles and machinery

There is no data on the negative impact of the drug ACC® in recommended doses on the ability to drive vehicles and perform other activities that require concentration and speed of psychomotor reactions.

Special precautions when disposing of unused medicinal product There is no need for special precautions when destroying unused ACC® drug.

3 g of granules per bag made of a combined material (aluminum foil/paper/polyethylene). 20 and 50 sachets per cardboard box along with instructions for use.

At a temperature not higher than 25 °C.

Keep out of the reach of children.

Do not use after expiration date.

Sandoz d.d., Verovshkova 57, 1000 Ljubljana, Slovenia; Manufactured by: Lindopharm GmbH, Neustrasse 82, Hilden, Germany. Consumer complaints should be sent to Sandoz CJSC:

125315, Moscow, Leningradsky Prospekt, 72, bldg. 3.; telephone: ; Fax: .

Source: http://med2c.ru/%D0%B0%D1%86%D1%%D0%BF%D0%BE%D1%80%D0%BE%D1%88%D0%BE%D0%BA- %D0%B8%D0%BD%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%86%D0%B8%D1%8F/

ACC - instructions for use. How to drink effervescent tablets, powder or cough syrup for adults and children ACC

Most diseases are always accompanied by a cough, so it is understandable that there is a desire to get rid of it faster. The range of anti-influenza and expectorant drugs is wide. How to make the right choice? Not every medication is suitable for treating dry or wet cough. Likewise, ACC cannot always be used.

ACC - indications for use

The medicine ass is a mucolytic, expectorant and detoxifying agent prescribed for severe coughs in children and adults. This drug is capable of not only thinning mucus, but also effectively removing it from the lungs and bronchi, relieving inflammation, and improving the functioning of the body’s secretomotor functions. The ACC instructions state that it can be used if you have the following health conditions:

  • acute or chronic bronchiolitis and bronchitis;
  • sinusitis;
  • asthma;
  • pneumonia;
  • pulmonary eczema;
  • tuberculosis;
  • otitis media;
  • cold.

Even this is not all the possibilities of the ACC. Due to its medicinal properties, the drug is often used for cystic fibrosis, a hereditary disease caused by a gene mutation. In addition, it is often prescribed for the treatment of mild or prolonged inflammatory processes of the nasopharynx: tracheitis, acute rhinitis, nasopharyngitis, sinusitis, which are accompanied by the accumulation of large amounts of purulent mucus.

For what cough is ACC prescribed?

If you already have a package of the product in your house, then before going to the pharmacy, you can independently study for which cough you drink ACC. However, complex medical terms and phrases will not be understandable to everyone. Doctors recommend taking the medicine for a wet, productive cough - when excess viscous or too thick sputum accumulates in the bronchi.

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ACC – at what age can it be given to children?

Many young mothers ask: is it possible to give ACC to children and at what age? To which experienced pediatricians answer with confidence: not only is it possible, but it is necessary. The main thing is to do it correctly:
  • A child from 2 years to 6 years old can only be given ACC 100 mg, which is available as a powder.
  • Starting from 7 years of age, treatment with ACC 200 mg is allowed. This medicine can be found in granules.
  • ACC 600 is available for children 14 years of age and older. Unlike other medications, this type of medication is effective for 24 hours.
  • As a syrup, the medicine can be given to infants, but only under the supervision of a pediatrician.

Method of using ACC

For convenience, many pharmaceutical companies began to produce medicine in several forms: granules, for example, with orange flavor, instant tablets, syrup. Each form has its own doses and limits on how to take ACC:

  • It is extremely rare that the solution is prescribed for inhalation. If the nebulizer used for the procedure is equipped with a distribution valve, then you need to use 6 ml of a 10% powder solution. If there is no such supplement, doctors recommend taking a 20% solution at the rate of 2-5 ml per 1 liter of water.
  • For bronchoscopy, severe rhinitis, and sinusitis, the use of ACC intratracheally is allowed. To clean the bronchi and sinuses, use a 5-10% solution. The diluted liquid must be dripped into the nose and ears in a volume of up to 300 mg per day.
  • When using the parenteral method, ACC is administered intramuscularly or intravenously. In the latter case, the ampoule must be diluted with sodium chloride or dextrose in proportions of 1 to 1.

ACC-long - instructions for use

The ACC product marked long differs from ordinary tablets or powder in that its effect lasts not 5-7 hours, but the whole day. The medicine is produced in the form of large effervescent tablets and is intended for oral administration, 1 tablet 1 time per day, unless otherwise recommended by a doctor. Additionally, along with the medicine, you need to drink up to one and a half liters of liquid, which enhances the mucolytic effect.

How to breed ACC Long:

  1. Pour clean, chilled boiled water into a glass and place a tablet at the bottom.
  2. Wait until the effervescent effect wears off and the capsule dissolves completely.
  3. Once dissolved, drink the solution immediately.
  4. Sometimes before drinking ACC, the diluted drink can be left for several hours.

ACC powder - instructions for use

ACC powder is used in the following doses:

  • adolescents over 14 years of age and adults are prescribed up to 600 mg of acetylcysteine, the dose is divided into 1-3 approaches;
  • it is recommended to give a child under 14 years of age the same dose of the drug, but divided into several doses per day;
  • Children under 6 years old can be given mg of powder per day.

Both adults and children should drink ACC powder after meals, and the composition from the bag must be properly prepared. What water to dissolve ACC in depends on your preferences, but remember: the best result will be achieved if you dilute the medicine with half a glass of hot water. However, baby granules with orange flavor can be dissolved in lukewarm, boiled water.

ACC effervescent tablets - instructions for use

Acetylcysteine ​​effervescent tablets are diluted with water using the same system as regular powder. The dose of the drug, in the absence of other doctor’s recommendations, is:

  • for cold infectious diseases that occur in a mild form, adults - 1 tablet of ACCraza per day, for 5-7 days;
  • for chronic cough, bronchitis or cystic fibrosis, the medicine is taken for a longer period, and its dose for adults is 2 capsules of ACC 100 three times a day.

ACC syrup for children - instructions

Sweet ACC syrup is prescribed to children aged two years and older when diagnosing mild colds or chronic bronchitis. The medicine is taken orally for 5 days, immediately after meals. The dosage of syrup is chosen by the attending physician. If no recommendations have been received from the pediatrician, then the guide will be ACC - the official instructions for use from the manufacturer, which states that you can take the medicine:

  • adolescents: 10 ml 3 times/day;
  • if the child is from 6 to 14 years old, then 5 ml 3 times a day;
  • for children 5 years old, the dose of the medicine is 5 ml 2 times a day.

Remove the baby syrup from the bottle using a measuring syringe. The device comes complete with the medicine. Instructions for using the syringe are as follows:

  1. Press the bottle cap and turn it clockwise until it clicks.
  2. Remove the cap from the syringe, insert the hole into the neck and press the syringe until it stops.
  3. Turn the bottle upside down, pull the handle of the syringe towards you, measuring the required dose of syrup.
  4. If bubbles appear inside the syringe, lower the plunger slightly.
  5. Slowly pour the syrup into the child's mouth and allow the child to swallow the medicine. Children should stand or sit while taking the drug.
  6. After use, the syringe should be washed without soap.

Analog of ACC

If you are looking for a cheap analogue of ACC cough medicine, pay attention to the following medicines:

  • Ambroxol, country of origin – Russia. It contains the same active ingredient and belongs to the category of mucolytic expectorants. Its price is about rubles.
  • Fluimucil, country of origin: Italy. Designed to eliminate the first signs of a cold and cough, but can be used to ease the discharge of viscous secretions from the nose. Its composition consists of 600 mg of acetylcysteine, citric acid, sorbitol and flavorings. The price of the drug is about 300 rubles.
  • Ambrobene, country of origin - Germany. It is produced as a syrup based on another active substance – ambroxol hydrochloride. The medicine helps to cope with a protracted, poorly expectorated cough, removes mucus from the bronchi, and softens the respiratory tract. Its price ranges from 200 to 300 rubles.

Price of ACC for cough

The form of release not only contributed to the freedom of choice of the buyer, but also significantly influenced how much ACC costs in pharmacies. More often, its price is very reasonable, which makes the medicine accessible to every social class of the population. However, in different cities and pharmacies, prices for medicine may vary slightly. The average cost of the drug is:

  • baby syrup – price up to 350 rubles;
  • granular ACC - up to 200 rubles;
  • powder – r.;
  • orange and honey flavored powder – price from 250 rub.

ACC - contraindications

Contraindications to the use of ACC are as follows:

  • individual intolerance to the active substance;
  • hypersensitivity to additional components of the drug;
  • illness during pregnancy, during lactation, excluding artificial feeding;
  • ulcer of the duodenum and stomach;
  • liver failure;
  • history of pulmonary hemorrhage.

In addition, it is highly undesirable to use the medicine together with other cough syrups, bronchodilators and antibiotics that contain codeine and inhibit expectorant reflexes. Those who have previously been diagnosed with venous enlargement of the veins, diseases of the adrenal glands or abnormalities in the functioning of the endocrine system should take the medicine with caution.

Side effects of ACC

Overdose symptoms and side effects of ACC appear as:

  • allergic reactions: skin itching, urticaria, dermatitis, laryngeal edema, anaphylactic shock;
  • deterioration of health: muscle weakness, drowsiness, ringing in the ears, rapid heartbeat, migraine;
  • bowel dysfunction: severe diarrhea;
  • indigestion: nausea, heartburn, gag reflex after taking pills.

Video: ACC annotation

ACC - reviews

I suffered from cough for a long time. I can’t say that he was dry, but the phlegm still didn’t come out. I decided to go to the hospital and the doctor advised me to try ACC Long in effervescent tablets. I took the course as stated in the instructions for the medicine - 5 days. The cough has not gone away at all, but breathing has become much easier, and phlegm is already coming out of the bronchi.

Anastasia, 32 years old

At the beginning of treatment for a wet, persistent cough, a friend advised me to try ACC powder. When I came to the pharmacy, at first I was confused because of the price of the medicine. It cost somewhere around 130 rubles, which is very strange and inexpensive compared to its analogues. I decided to try it anyway and was not mistaken, the cold went away in 3 days, and my breathing returned to normal.

The information presented in the article is for informational purposes only. The materials in the article do not encourage self-treatment. Only a qualified doctor can make a diagnosis and make recommendations for treatment based on the individual characteristics of a particular patient.

Source: http://sovets.net/8509-atsts-instruktsiya-po-primeneniyu.html

ACC powder: instructions for use

The drug ACC is a drug that has a mucolytic effect and is intended for the treatment of a variety of diseases of the respiratory system. Available in granular form. The granules are intended for further dissolution in water and drinking.

Release form and composition

The active substance is acetylcysteine. The granules have a homogeneous consistency without lumps with an orange aroma. Each packet of granules contains 200 or 100 mg of acetylcysteine. In addition to the active substance, auxiliary components have been added to the composition: saccharin, ascorbic acid, sucrose and orange flavoring. A cardboard package may contain 50 or 20 disposable sachets, each of which is made of three-layer material. The package contains detailed instructions.

Indications for use

ACC should be used for the following painful conditions:

  • formation of difficult to separate sputum of viscous consistency;
  • obstructive bronchitis;
  • bronchiectasis;
  • laryngotracheitis;
  • bronchial asthma;
  • cystic fibrosis;
  • pneumonia;
  • in the treatment of chronic and acute sinusitis;
  • bronchiolitis;
  • otitis media;
  • other diseases of the respiratory system.

Contraindications

The ban on taking the ACC drug applies to nursing and pregnant women, children under two years of age, and patients with hypersensitivity to any component of this drug. Increased caution is required when prescribing ACC to people with varicose veins in the esophagus, hemoptysis, bronchial asthma (due to a possible complication in the form of bronchospasm), failure of the kidneys or adrenal glands, liver, or peptic ulcer. In pregnant women, taking ACC is possible only in extreme cases, when the benefit outweighs the likelihood of developing undesirable consequences.

Directions for use and dosage

ACC in adolescents, starting from the age of 14 years and in adults, is used according to the scheme. In the treatment of diseases of the respiratory system, you should take 1 packet containing acetylcysteine ​​200 mg or 2 packets with 100 mg of the drug 3 times over 24 hours. The total dose of acetylcysteine ​​ranges from 400 to 600 mg per day. It is divided into several doses after consultation with a doctor.

Children from 6 to 14 years of age should consume 300–400 mg of the drug per day. The dose is divided into 3 or 2 times at approximately equal intervals.

Children from 2 to 5 years old are prescribed ACC at a dose of 100 mg twice a day.

A different treatment regimen is performed in the treatment of cystic fibrosis. From the age of six, three doses of 200 mg are required. Children 2–5 years old should take 100 mg of the drug four times in 24 hours. Sometimes it is necessary to increase the daily dose to 800 mg in patients who weigh more than 30 kg.

Diseases that last a short time require treatment with ACC for about 6 to 7 days. In the case of treatment of cystic fibrosis or chronic problems with the respiratory system, a long course is required, selected by the doctor strictly individually.

How to dilute ACC powder?

The drug ACC is prescribed strictly after meals. The granules in the bag must be dissolved in a cool liquid (tea, water, juice). Parallel intake of liquids significantly increases the activity of acetylcysteine.

Side effects

During therapy, the following unpleasant complications may occur:

  • headache;
  • noise in ears;
  • the appearance of inflammatory elements in the oral cavity;
  • nausea or heartburn;
  • stool disorder;
  • tachycardia;
  • decreased blood pressure;
  • Isolated complaints of allergic complications were recorded. The most common occurrence is bronchospasm, which is usually recorded in patients with increased bronchial reactivity. Possible itching or rash;
  • development of bleeding (extremely rare).

special instructions

Patients with diabetes mellitus should take into account the fact that a packet of ACC with a dosage of 200 mg corresponds to 0.23 VE, and with a dosage of 100 mg - 0.24 VE. The granules contain sucrose. When feeding and lactation, ACC is prescribed under strict medical supervision in extreme cases.

It is prohibited to use ACC with substances that have an antitussive effect. Possible stagnation of mucus in the bronchi. You need to know that nitroglycerin taken simultaneously with acetylcysteine ​​will enhance its vasodilating effect. ACC is incompatible with drugs related to antibiotics. This is especially true for cephalosporins, penicillins, erythromycin, amphotericin B and tetracycline. It is also impossible to take ACC with proteolytic enzymes. ACC granules dissolve only in glass containers. Do not use metal utensils. In the presence of bronchial asthma or obstructive bronchitis, acetylcysteine ​​is prescribed with periodic monitoring of bronchial patency.

Analogues of ACC

Preparations containing acetylcysteine: Acestad tablets and granules, Acestal S, ACC hot drink, ACC tablets, Fluimucil and many others.

Drugs with a similar therapeutic effect include Ambroxol, Sudafred, Fluifort, Lazolvan, Bromhexine.

Terms and conditions of storage

ACC can be stored in rooms with a room temperature of about 25 degrees. The shelf life in original packaging is 4 years. The drug should be hidden from children. Dispensing from pharmacies is permitted without a prescription.

ACC powder price

ACC granules for the preparation of oral solution 100 mg, 20 pcs. — from 113 rub.

ACC granules for the preparation of oral solution 200 mg, 20 pcs. — from 121 rub.

Source: http://bezboleznej.ru/acc-poroshok

Krasnoyarsk medical portal Krasgmu.net

Instructions for the drug ACC 200: description of the drug, annotation, in what doses to take it, composition, contraindications and side effects.

Tradename

International nonproprietary name

Dosage form

Powder for solution for oral administration 200 mg

Composition of the drug ACC 200

1 sachet (bag) with 3 g of powder contains

active substance – acetylcysteine ​​200 mg

excipients: ascorbic acid (vitamin C), saccharin, sucrose, orange flavor.

Description of the drug ACC 200

Fine, homogeneous, white or yellowish powder with an orange odor.

The resulting solution: colorless, slightly opalescent, with the smell of orange.

Pharmacotherapeutic group

Expectorants. Mucolytics.

ATC code R05 CB01

Pharmacological properties

Pharmacokinetics

After oral administration, acetylcysteine ​​(ACC 200) is rapidly absorbed from the gastrointestinal tract (GIT) and metabolized in the liver into cysteine, a pharmacologically active metabolite, as well as into diacetylcysteine, cystine and various mixed disulfides.

Due to the high first pass effect through the liver, the bioavailability of acetylcysteine ​​is very low (approximately 10%).

In humans, maximum plasma concentrations are reached after 1-3 hours. The maximum plasma concentration of the cysteine ​​metabolite is about 2 µmol/l. The binding of acetylcysteine ​​to plasma protein is approximately 50%.

Acetylcysteine ​​is excreted through the kidneys almost exclusively in the form of inactive metabolites (inorganic sulfates, diacetylcysteine).

The half-life in plasma is approximately 1 hour and is mainly determined by hepatic biotransformation. Therefore, impaired liver function leads to prolonged plasma elimination half-lives of up to 8 hours.

Pharmacodynamics

Acetylcysteine ​​is a derivative of the amino acid cysteine. Acetylcysteine ​​has secretolytic and secretomotor effects in the respiratory tract. It breaks disulfide bonds between mucopolysaccharide chains and has a depolymerizing effect on DNA chains (in purulent sputum). Thanks to these mechanisms, the viscosity of sputum decreases.

An alternative mechanism of acetylcysteine ​​is based on the ability of its reactive sulfhydryl group to bind chemical radicals and thereby neutralize them.

Acetylcysteine ​​helps increase glutathione synthesis, which is important for the detoxification of toxic substances. This explains its antidote effect in paracetamol poisoning.

When used prophylactically, it has a protective effect on the frequency and severity of exacerbations of bacterial infections, which was found in patients with chronic bronchitis and cystic fibrosis.

Indications for use ACC 200

Mucolytic therapy of acute and chronic bronchopulmonary diseases accompanied by impaired secretion and transport of sputum.

Directions for use and dosage

ACC® 200 is taken only in the form of a prepared solution, after meals.

Adults and teenagers aged 14 years and older

1 sachet of powder 2-3 times a day (corresponds to mg of acetylcysteine ​​per day).

Children and teenagers from 6 to 14 years old

1 sachet of powder 2 times a day (corresponds to 400 mg of acetylcysteine ​​per day).

Children over 6 years of age

1 sachet of powder 3 times a day (corresponds to 600 mg of acetylcysteine ​​per day).

For children under 6 years of age, ACC® junior cough syrup is recommended.

The duration of treatment depends on the type and severity of the disease and should be determined by the attending physician.

In the case of chronic bronchitis and cystic fibrosis, long-term treatment should be carried out to prevent infection.

The powder is dissolved in a glass of boiled water and taken after meals.

Side effects on ACC 200

- rarely (³ 0.1% - < 1%): stomatitis, diarrhea, vomiting, heartburn and nausea, headache, tinnitus; bleeding, partly associated with hypersensitivity reactions; decreased platelet aggregation

- very rarely (<0.01%): allergic reactions - itching, urticaria, skin rash, bronchiolospasm, tachycardia and arterial hypotension.

Reports regarding bronchiolospasm primarily concerned patients with increased bronchial system reactivity associated with bronchial asthma.

Contraindications to the drug ACC 200

- hypersensitivity to acetylcysteine ​​or any other component of the drug

Drug interactions

The simultaneous use of acetylcysteine ​​and antitussives can cause dangerous secretory stagnation due to a decrease in the cough reflex. For this reason, this combination therapy option must be based on a particularly accurate diagnosis.

Tetracycline chloride should be administered separately and at least two hours apart.

Reports regarding inactivation of antibiotics (semisynthetic penicillins, tetracyclines, cephalosporins and aminoglycosides) resulting from concomitant use of acetylcysteine ​​or other mucolytic drugs are based solely on laboratory experiments in which the relevant substances were directly mixed. However, for safety reasons, oral antibiotics should be administered separately at least two hours apart.

In cases of simultaneous administration of nitroglycerin (glycerol trinitrate) with acetylcysteine, an increase in its vasodilatory effect and inhibitory effect on platelet aggregation was observed. The clinical significance of these data has not yet been established.

special instructions

The secretolytic effect of ACC® is supported by sufficient fluid intake.

Caution should be exercised when prescribing ACC to patients with a history of bronchial asthma or peptic ulcer disease.

Pregnancy and lactation

The use of ACC is not recommended, because There is no experience of use during pregnancy and lactation.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

The drug does not affect the ability to concentrate.

Overdose

Release form and packaging

ACC® 200 is available in sachets/bags of 3 g; No. 20, 50 or 100 sachets in a cardboard box along with enclosed instructions for use.

Storage conditions

Store at a temperature not exceeding +30°C.

Keep out of the reach of children!

Shelf life

Do not use after the expiration date stated on the packaging.

Vacation conditions

Manufacturer

Salutas Pharma GmbH

D-39179, Barleben, Germany

Hexal AG, Germany Industrialstrasse 25

Holzkirchen, Germany

Salutas Pharma GmbH

D-39179, Barleben, Germany

Hexal AG, Germany Industriestraβe 25 DHolzkirchen, Germany

Source: http://krasgmu.net/publ/acc_200_poroshok_dlja_prigotovlenija_rastvora_dlja_priema_vnutr_instrukcija_opisanie/

ACC 200 (powder): instructions for use

Dosage form

Powder for solution for oral administration 200 mg

Compound

1 sachet contains 3 g of powder

active substance: acetylcysteine ​​200 mg

excipients: sucrose, ascorbic acid, saccharin, dry orange flavor 1:1000 Sotteri 289**

(**- Orange flavor essence 11.1%, dextrose anhydride 82.7%, lactose 6.2%)

Description

Powder from white to yellowish color, with partial agglomeration of particles, with the smell of orange.

The reconstituted solution is colorless, transparent or slightly opalescent.

Pharmacotherapeutic group

Drugs for the treatment of diseases of the respiratory system. Medicines to relieve symptoms of colds and coughs. Expectorants. Mucolytics. Acetylcysteine

ATX code R05 CB01

Pharmacological properties

After oral administration, acetylcysteine ​​is rapidly absorbed from the gastrointestinal tract (GIT) and metabolized in the liver to cysteine, a pharmacologically active metabolite, as well as diacetylcysteine, cystine and various mixed disulfides.

Due to the high first pass effect through the liver, the bioavailability of acetylcysteine ​​is very low (approximately 10%).

In humans, maximum plasma concentrations are reached after 1-3 hours. The maximum plasma concentration of the cysteine ​​metabolite is about 2 µmol/l. The binding of acetylcysteine ​​to plasma protein is approximately 50%.

Acetylcysteine ​​is excreted through the kidneys almost exclusively in the form of inactive metabolites (inorganic sulfates, diacetylcysteine).

The half-life in plasma is approximately 1 hour and is mainly determined by hepatic biotransformation. Therefore, impaired liver function leads to a prolongation of the plasma half-life of up to 8 hours.

Acetylcysteine ​​is a derivative of the amino acid cysteine. Acetylcysteine ​​has secretolytic and secretomotor effects in the respiratory tract. It breaks disulfide bonds between mucopolysaccharide chains and has a depolymerizing effect on DNA chains (with purulent sputum). Thanks to these mechanisms, the viscosity of sputum decreases.

An alternative mechanism of acetylcysteine ​​is based on the ability of its reactive sulfhydryl group to bind chemical radicals and thereby neutralize them.

Acetylcysteine ​​helps increase glutathione synthesis, which is important for the detoxification of toxic substances. This explains its antidote effect in paracetamol poisoning.

When used prophylactically, it has a protective effect on the frequency and severity of exacerbations of bacterial infections, which was found in patients with chronic bronchitis and cystic fibrosis.

Indications for use

— secretolytic therapy for acute and chronic diseases of the bronchi and lungs, accompanied by impaired formation and elimination of sputum.

Directions for use and dosage

ACC® 200 is taken only in the form of a prepared solution, after meals.

Adults and teenagers aged 14 years and older

1 sachet of powder 2-3 times a day (corresponds to mg of acetylcysteine ​​per day).

Children and teenagers from 6 to 14 years old

1 sachet of powder 2 times a day (corresponds to 400 mg of acetylcysteine ​​per day).

The duration of treatment depends on the type and severity of the disease and should be determined by the attending physician.

The powder is dissolved in a glass of boiled water and taken after meals.

For children under 6 years of age, other forms of ACC are recommended: ACC® junior, powder for oral solution, 20 mg/ml, ACC®100, effervescent tablets, 100 mg, ACC®200, effervescent tablets, 200 mg.

Side effects

Uncommon (≥1/1000, <1/100)

- allergic reactions (itching, urticaria, skin rash, bronchospasm, Quincke's edema, exanthema)

- stomatitis, abdominal pain, diarrhea, vomiting, heartburn, nausea

Rarely (≥1/10000, <1/1000)

- shortness of breath, bronchospasm, mainly in patients with increased reactivity of the bronchial system associated with bronchial asthma

Very rare (< 1/10,000)

- bleeding and hemorrhage, partly associated with hypersensitivity reactions

- anaphylactic reactions, up to anaphylactic shock

- Stevens-Johnson syndrome, Lyell's syndrome

Various studies have shown a decrease in platelet aggregation under the influence of acetylcysteine. At present, the clinical significance of this phenomenon has not been established.

Contraindications

- hypersensitivity to any component of the drug

- peptic ulcer of the stomach and duodenum in the acute stage

- hemoptysis, pulmonary hemorrhage

- bronchial asthma in the acute stage

- children up to 6 years old

- intolerance to fructose, galactose, deficiency of saccharin-isomaltose, lactose, glucose-galactose malabsorption syndrome

With caution: varicose veins of the esophagus, bronchial asthma, diseases of the adrenal glands, liver and/or kidney failure, arterial hypertension.

Drug interactions

The simultaneous use of acetylcysteine ​​and antitussives can cause dangerous secretory stagnation due to a decrease in the cough reflex. For this reason, this combination therapy option must be based on a particularly accurate diagnosis.

To achieve the best therapeutic effect, oral antibiotics (penicillins, tetracyclines and aminoglycosides) should be administered separately, with a two-hour time interval. This does not apply to cefixime and loracarbef.

The use of activated carbon in large doses can weaken the effect of acetylcysteine.

The simultaneous use of nitroglycerin and acetylcysteine ​​should be carried out under the supervision of a physician, as the vasodilatory effect and inhibitory effect on platelet aggregation may be enhanced.

Acetylcysteine ​​may interfere with the colorimetric assay for the determination of salicylates.

Acetylcysteine ​​may interfere with the results of ketone bodies in urine tests.

special instructions

If changes occur in the skin and mucous membranes, the patient should immediately stop taking acetylcysteine ​​and consult a doctor.

In patients with bronchial asthma and obstructive bronchitis, ACC® 200 should be prescribed with caution under systematic monitoring of bronchial conduction due to the risk of developing bronchospasm.

The use of the drug ACC® 200 can lead to dilution of sputum in the bronchi and a slight increase in its volume. If the cough reflex is insufficient, postural drainage or aspiration is used.

Patients with histamine intolerance should take ACC® 200 in short courses, due to the effect on the metabolism of histamine itself and the possible appearance of intolerance symptoms (for example, headache, runny nose, itching).

1 sachet contains 2.7 g of sucrose. This should be taken into account when prescribing ACC® 200 to patients with diabetes mellitus.

Pregnancy and lactation

The use of ACC® 200 during pregnancy and lactation is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus and child.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Overdose

Symptoms: nausea, vomiting, diarrhea; children have a risk of hypersecretion.

Release form and packaging

3 g per sachet. 20 or 50 sachets along with instructions for medical use in the state and Russian languages ​​are placed in a cardboard pack

Storage conditions

Store at a temperature not exceeding 30°C.

Keep out of the reach of children!

Shelf life

Do not use after the expiration date.

Conditions for dispensing from pharmacies

Manufacturer

Lindopharm GmbH., Germany

Neustraße 82, DHilden, Germany

You should consult your doctor and read the instructions before use.

Source: http://tab.103.kz/atsts-200-poroshok-instruktsiya/

Acc instructions in powder

Use the site search:

Instructions for use:

Prices in online pharmacies:

ACC is a drug belonging to the group of mucolytic drugs. The active ingredient of the drug is acetylcysteine.

pharmachologic effect

ACC helps liquefy mucus in the respiratory tract and eliminate it, and has an expectorant effect. ACC is an antidote (a substance that can neutralize the toxic effects of poisons and toxins) for poisoning with paracetamol, aldehydes, and phenols.

ACC is well absorbed from the gastrointestinal tract, the maximum level of the drug in the blood is observed 1-3 hours after administration. The binding of acetylcysteine ​​to plasma proteins is 50%. The drug is excreted in urine and feces (insignificant amounts). The half-life during normal liver function is 1 hour, and in case of liver failure it is extended to 8 hours.

ACC passes through the placenta and can accumulate in amniotic fluid.

Release form

ACC 100 and ACC 200 are available in the form of effervescent tablets, 20 pieces per package.

ACC hot drink is available in the form of powder for preparing the drink, 200 and 600 mg per package.

ACC Long is produced in the form of effervescent tablets, 600 mg per package (10 pieces).

ACC powder for the preparation of a solution for internal use, 100 and 200 mg per package.

Children's ACC is produced in the form of powder for internal use, 30 grams in a 75 ml bottle and 60 grams in a 150 ml bottle.

Indications for use of ACC

Indications for the use of ACC are all diseases and conditions in which there is an accumulation of sputum in the respiratory tract. These include:

- bronchitis in acute and chronic form;

- exudative otitis media of the middle ear.

Method of administration of ACC and dose

According to the instructions, ACC is used for the treatment of cystic fibrosis in the following doses:

— for patients weighing more than 30 kg, the daily dose of ACC is 800 mg;

— ACC for children from the 10th day of life to 2 years of age is used 50 mg 2-3 times a day;

— ACC for children from 2 to 5 years is prescribed at a dose of 400 mg/day. The daily dose is divided into four doses.

— ACC for children after six years of age is used at a dose of 600 mg, which is divided into 3 doses per day.

The course of treatment for ACC is from 3 to 6 months.

According to the instructions, ACC is used for other diseases according to a different scheme.

The use of ACC for adults and children after 14 years of age ranges from 400 to 600 mg per day.

The use of ACC for children from 6 to 12 years old is mg, divided into 2 doses per day.

ACC for children from 2 to 5 years of age is prescribed as a daily dose, which must be divided into 2 doses.

For children from the 10th day of life to 2 years of age, the use of ACC is indicated at a dose of 50 mg 2-3 times a day.

The course of treatment for an uncomplicated course of the disease is 5-7 days; in the presence of complications or a chronic course of the disease, the course of treatment can vary widely and reach 6 months.

According to the instructions, ACC should be taken after meals. Dissolve effervescent tablets (ACC 100, ACC 200, ACC long) or a sachet (ACC hot drink or ACC powder for oral solution, ACC for children) in 100 ml of liquid (tea, juice, water).

Side effects

The use of ACC can provoke the development of the following side effects:

— Gastrointestinal tract: diarrhea, nausea, vomiting, heartburn, stomatitis;

— CNS: tinnitus, headaches;

— Heart and blood vessels: arrhythmia, increased blood pressure.

Contraindications

Contraindications to the use of ACC are:

- increased sensitivity to ACC components;

- bleeding from the lungs;

- hepatitis and kidney failure (for children).

Pregnancy and lactation

Prescription of ACC during pregnancy and breastfeeding is possible only according to a doctor's indications.

additional information

ACC should be used with caution for gastric and duodenal ulcers.

Patients with bronchial asthma should prepare the ACC solution with care, since particles of the drug inhaled with air can cause bronchial spasm.

For a more effective mucolytic effect (thinning and removal of sputum), you should drink plenty of fluids along with taking the drug.

ACC is prescribed to newborns in exceptional cases as prescribed by the doctor.

ACC 200 is not recommended for use in children under 2 years of age.

ACC Long is not recommended for use in children under 14 years of age.

Storage conditions

The drug must be kept out of the reach of children at a temperature of no more than 30 degrees. The prepared solution must be stored in the refrigerator for no more than 12 days.

Acc por. d/prep. solution d/vn. taking 200 mg No. 20 (orange)

ACC granules 200 mg orange 20 pcs.

ACC granules 100 mg orange 20 pcs.

Acc gran. d/r-ra internal 600mg n6

ACC 100 mg granules for prig. oral solution 3g No. 20 sachets

ACC granules 100 mg n20 sachet

ACC 200 mg granules for prig. oral solution 3g No. 20 sachets

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

What to do if a child has eaten an ACC Long tablet

What to do if a child has eaten an ACC Long tablet

Depends on how old the child is and how much time has passed since he took the pill. The algorithm is as follows: you need to try to induce vomiting, then give activated carbon (at the rate of 1 tablet per 10 kg of weight) or Smecta, or another sorbent. Then drink plenty of fluids.

If the child is small, vomiting cannot be induced at home, only in the hospital.

I dissolve it in warm water.

In water at room temperature or warm.

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Source: http://www.neboleem.net/acc.php