How to dilute cefazolin correctly

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Cefazolin - instructions for use, analogues, reviews, price

Release forms and name

Dosage

  • 250 mg;
  • 500 mg;
  • 1 g (1000 mg).

This is exactly how much (250, 500 or 1000) milligrams of powder are in one bottle.

Table of contents:

Therapeutic effects and spectrum of action of Cefazolin

  • Staphylococcus aureus (Staphylococcus aureus);
  • Epidermal staphylococcus (Staphylococcus epidermidis);
  • Beta-hemolytic streptococci from group A;
  • Pyogenic streptococcus (Streptococcus pyogenes);
  • Diplococcus pneumoniae;
  • Hemolytic streptococcus (Streptococcus hemolyticus);
  • Viridal streptococcus (Streptococcus viridans);
  • Escherichia coli;
  • Klebsiella spp.;
  • Proteus (Proteus mirabilis);
  • Enterobacter aerogenes;
  • Haemophilus influenzae (Haemophilus influenzae);
  • Salmonella (Salmonella spp.);
  • Shigella (Shigella disenteriae, etc.);
  • Neisseria (Neisseria gonorrhoeae and Neisseria meningitidis);
  • Corynebacterium diphtheriae;
  • The causative agent of anthrax (Bacillus anthracis);
  • Clostridia (Clostridium pertringens);
  • Spirochetes (Spirochaetoceae);
  • Treponema (Treponema spp.);
  • Leptospira spp.

This means that Cefazolin is able to cure infection of any organ caused by the above pathogenic microorganisms. Unfortunately, due to the frequent and unjustified use of antibiotics, their spectrum of action is steadily decreasing as resistant types of microorganisms emerge. Therefore, after 5 years, this list of bacteria on which Cefazolin has a detrimental effect may change significantly.

Indications for use

  • acute and chronic bronchitis;
  • infected bronchiectasis;
  • pneumonia caused by bacteria (not fungi or viruses);
  • bronchopneumonia;
  • chest infections that developed after surgery (for example, after puncture, etc.);
  • pleural empyema;
  • lung abscess;
  • otitis media;
  • tonsillitis;
  • mastoiditis;
  • acute and chronic pyelonephritis;
  • cystitis;
  • urethritis;
  • prostatitis;
  • gonorrhea;
  • skin infections;
  • cellulite;
  • mastitis;
  • erysipelas;
  • carbuncles;
  • infected gangrene;
  • infection on a wound or burn surface;
  • skin or soft tissue infection after surgery;
  • eye infection;
  • osteomyelitis;
  • septic arthritis;
  • biliary tract infections;
  • infection after abortion;
  • uterine infection;
  • salpingitis;
  • pelvic abscess;
  • endocarditis;
  • syphilis;
  • sepsis;
  • peritonitis.

The above pathologies can be successfully cured with Cefazolin. However, the antibiotic can also be used to prevent the development of infection before and after surgery during removal of the uterus, gallbladder, and operations on the heart, bones and joints.

Cefazolin injections - instructions for use

1. Mild infections caused by cocci (staphylococci, streptococci) require the use of Cefazolin at a dose of 500 mg - 1 g every 12 hours. 500 mg can be administered every 8 hours. The maximum daily dose is 1.5 – 2 g.

2. Acute uncomplicated urinary tract infections (urethritis, cystitis, etc.) - Cefazolin is administered 1 g every 12 hours. The daily dose of antibiotic is 2 g.

3. Pneumonia caused by pneumococci requires the administration of Cefazolin 500 mg every 12 hours. The daily dosage of the antibiotic is 1 g.

4. Severe or moderate infections require the use of Cefazolin 500 mg - 1 g every 6 - 8 hours. The daily dose is 3 – 4 g.

5. Life-threatening infections are treated by administering 1 - 1.5 g of Cefazolin every 6 hours. In this case, a person receives 4–6 g of antibiotic per day.

If a person's kidney function is unstable, it is necessary to constantly monitor creatinine clearance using the Rehberg test. In this case, the dose of Cefazolin is determined every day, depending on laboratory parameters.

How to dilute the antibiotic Cefazolin - recipe

  • sterile saline solution;
  • 5% or 10% glucose solution;
  • glucose solution in saline;
  • glucose solution in Ringer's solution;
  • 5% or 10% fructose solution in water for injection;
  • Ringer's solution;
  • 5% sodium bicarbonate solution.

Most often, intramuscular injections of Cefazolin are used at home. Therefore, we will consider in detail how to properly dilute the powder in solutions of the anesthetics Lidocaine and Novocaine.

Cefazolin with Novocaine and Cefazolin with Lidocaine - how to dilute?

1. Carefully file and break off the tip of the ampoule with a 2% solution of Novocaine or 0.5% Lidocaine.

2. Open the sterile syringe, put on the needle and lower it into the ampoule with Novocaine or Lidocaine.

3. Draw the required amount of Novocaine or Lidocaine into the syringe (2 or 4 ml).

4. Remove the syringe from the ampoule with Novocaine or Lidocaine.

5. Remove the metal cap from the bottle of Cefazolin powder.

6. Pierce the rubber cap of the bottle with Cefazolin with the syringe needle.

7. Carefully squeeze out the entire contents of the syringe into the bottle with powder.

8. Without removing the syringe, shake the bottle until the powder is completely dissolved.

9. Draw the prepared solution into a syringe.

10. Remove the syringe from the rubber stopper and turn it upside down with the needle.

11. Tap the surface of the syringe with your finger in the direction from the piston to the needle so that air bubbles collect at the base.

12. Press the syringe plunger to release the air.

13. Make an intramuscular injection.

Cefazolin injections - instructions for use for children

  • For mild and moderate infections, the daily dosage is calculated at the rate of 25–50 mg of antibiotic per 1 kg of child’s weight. The resulting amount is divided into 2 - 4 administrations per day.
  • For severe infections, the dosage is calculated at the rate of 100 mg of Cefazolin per 1 kg of child’s weight. The calculated daily dosage is divided into 3 to 4 administrations.
  • Newborns and premature infants weighing less than 2 kg receive Cefazolin in a single dose of 20 mg per 1 kg, every 12 hours. That is, the daily dose of antibiotic is 40 mg per 1 kg of body weight.
  • For children over 7 days old and weighing more than 2 kg, the daily dose of the drug is determined at the rate of 60 mg per 1 kg of weight.

In newborns and children under 1 month of age, the elimination rate of Cefazolin is low, so it is not recommended to exceed the recommended dosage.

1. Calculate the dose based on body weight, as for a child who does not suffer from kidney pathology.

2. Perform the Rehberg test and evaluate creatinine clearance.

3. Calculate the dose of Cefazolin that can be administered to the child according to the ratios shown in the table:

However, the first dose of Cefazolin is administered completely to children suffering from renal failure. And then all subsequent ones are reduced to the required amount, depending on creatinine clearance.

Cefazolin injections for children - how to dilute?

1. Open the ampoule with Lidocaine or Novocaine, dip the tip of the syringe needle into the solution.

2. Take the required amount of solution - 2 or 4 ml of Novocaine or Lidocaine.

3. Pierce the cap of the bottle with Cefazolin powder with a needle.

4. Pour Novocaine or Lidocaine into the bottle and, without removing the needle, vigorously mix the contents to obtain a solution.

5. Carefully draw the entire contents of the bottle into the syringe.

6. Remove the syringe from the bottle and give an intramuscular injection.

Use during pregnancy

How to inject the antibiotic Cefazolin?

1. Treat the injection site with an antiseptic (70% alcohol, etc.).

2. Use only a sterile syringe with a sterile needle.

3. Release the air from the syringe with the prepared solution.

4. Position the needle vertically to the surface of the skin and insert it deep into the muscle.

5. Slowly press the plunger, injecting the medicine over 3 to 5 minutes.

6. Having injected the entire solution, remove the needle, holding it by the edge placed on the syringe.

How much to inject Cefazolin?

Side effects

Contraindications

Analogs

Analogues of the drug Cefazolin include only antibiotics from the group of first generation cephalosporins, which are intended for oral or injection use. That is, analogues are antibiotics that have the same spectrum of action as Cefazolin and belong to the same group and the same generation. Analogues of Cefazolin include the following drugs:

  • Cephalexin granules, capsules, powder and tablets;
  • Cephalothin powder;
  • Ecocephron capsules.

Reviews

When purchasing Cefazolin, you should pay attention to the integrity of the packaging. If the bottles have damaged packaging, you should not purchase the drug, as it may be of poor quality.

Cefazolin for cats

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Cefazolin: how to dilute novocaine for injection for children and adults?

Of all the cephalosporin antibiotics, Cefazolin is the least toxic, and therefore quite safe, as far as it is possible to apply antibiotics. This antimicrobial agent has a wide range of uses, however, questions may arise with its direct use, since the drug requires preparation. How to dilute Cefazolin for children and adults? How to give his injections correctly?

Cefazolin: indications for use

This semi-synthetic antibiotic has an effect on most unicellular microorganisms, gram-positive and gram-negative bacteria. It remains in the blood plasma for 12 hours, reaching its highest concentration 1 hour after administration intramuscularly or intravenously. Used in case:

  • Staphylococcus, syphilis, gonorrhea, sepsis
  • Inflammation of the abdominal cavity
  • Infections of the biliary and urinary tract, musculoskeletal system, ENT organs, respiratory system
  • Blood poisoning
  • To prevent complications after surgery

Side effects are most often observed in people who have individual intolerance to cephalosporins and penicillins, but the body may react with increased sensitivity in the nervous system (convulsions), digestive, urinary and skin manifestations (itching, inflammation, swelling). With prolonged use, dysbacteriosis develops.

  • Due to the fact that the drug is excreted by the kidneys, for any pathologies of this organ, the use of Cefazolin should be agreed with the attending physician, and the dosage is always reduced, the drug is administered once to prevent its accumulation in the kidneys.
  • The drug cannot be used during pregnancy and lactation, as well as in children under 1 year of age, and in premature infants. The use of Cefazolin for intestinal diseases is undesirable.

How to prepare Cefazolin for injection: instructions

Since the main form of release of this antibiotic is powder, it requires preliminary preparation. Sterile water for injection is mainly used, but sometimes it is diluted with novocaine or lidocaine, thereby reducing the sensitivity of the injection area. When administered intramuscularly, the injection of Cefazolin is always painful.

  • When Cefazolin is administered intravenously through a dropper, 1 g of powder is dissolved in isotonic sodium chloride or glucose solution with a 5% concentration. Liquid volumeml. The duration of the procedure is 30 minutes; it is performed twice for an adult. Maximum dosage - 6 g.
  • When Cefazolin is administered intramuscularly, through an injection, 0.5-2 g of powder accounts for 3 ml of water for injection. Sodium chloride can also be used. For an intravenous injection, the volume is increased to 10 ml.
  • How to dilute Cefazolin with novocaine? For this purpose, a 1% solution of novocaine (or a lower concentration) is used; for 1 g of Cefazolin there is 5 ml of novocaine.

The system for diluting powder with liquid looks like this:

  1. The foil is removed and the lid is treated with medical alcohol.
  2. The liquid is poured into a bottle with powder.
  3. The bottle is shaken to dissolve the granules.
  4. The resulting solution is injected into a syringe.

How to dilute Cefazolin for children?

The dosage of this antibiotic for children should be prescribed by a doctor, but in a critical situation you can calculate it yourself and also give your baby an injection yourself.

  • For each kg of net weight, take from 25 to 50 mg of Cefazolin, depending on the sensitivity of the body.
  • A bottle of powder for children should contain 0.5 g of antibiotic for the most accurate dosage. At higher concentrations (1 g, 2 g), 10 and 20 ml of liquid are taken, respectively.
  • Water for injection or novocaine is also added to the bottle, and the required number of ml for administration is removed with a syringe.

The above instructions and recommendations for the use of Cefazolin do not replace consultation with a specialist. If any side effects occur, use of the antibiotic should be discontinued. Remember that Cefazolin solution can only be administered if it is completely clear.

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I agree with the previous commentator. It must be diluted with lidocaine. Novocaine is too old a drug, doctors practically don’t use it, only surgeons can. A 1% solution of Lidocaine 3.5 ml will be enough for you if you use it correctly. I once read the annotation for lidocaine, and it clearly stated that it has indications for use with cephalosporin antibiotics, so you can’t go wrong with it.

Thanks for the interesting article. But for intramuscular injections for adults, Cefazolin must be dissolved in lidocaine. To effectively dissolve the antibiotic, it is recommended to use lidocaine in a 1% concentration of 3.5 ml, as it has a powerful analgesic effect. The drug belongs to the second generation of anesthetics, therefore it is more effective and safe in terms of the development of allergic reactions compared to representatives of the first generation of analgesics - Novocain. Referring to the chemical structure of analgesics of amide origin, Lidocaine penetrates better into body tissues and therefore causes greater pain relief compared to its predecessors from the group of esters, which are less soluble. To avoid side effects of the drug, consult your doctor before use. Before use, it is advisable to perform an allergy test to prevent possible adverse reactions in the form of individual intolerance to the components of the drug. All the best!

Source: http://ladyspecial.ru/zdorovie/narodnaya-mediczina/lekarstva-iz-apteki/tsefazolin-kak-razvodit-novokainom-dlya-inektsij-detyam-i-vzroslym

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How to dilute Cefazolin

Cefazolin is an antibiotic that belongs to the first generation of the cephalosporin group. It is administered only by injection, since when taken orally (in the form of tablets) it is destroyed in the gastrointestinal tract, without having time to be absorbed into the blood and have an antibacterial effect. This antibiotic has a wide spectrum of action, so it can be used to treat various infections caused by microbes sensitive to it. Cefazolin is used to treat organs of almost all systems, for example, reproductive, urinary, respiratory, skin, joints and so on.

The antibiotic Cefazolin is available only in the form of a dry powder, which is intended for intravenous or intramuscular administration. The powder is packaged in glass bottles and hermetically sealed.

The main therapeutic effect of Cefazolin is the destruction of the pathogenic microorganism that causes an infectious-inflammatory disease.

Cefazolin is effective against the following pathogenic microorganisms:

• Beta-hemolytic streptococci from group A;

• Causative agent of anthrax;

How to dilute Cefazolin

To dilute Cefazolin, use 0.5% or 1% solution of novocaine, 1% solution of lidocaine or water for injection. For intramuscular administration, Cefazolin is diluted with water only in cases of individual intolerance to solutions of novocaine or lidocaine by the patient.

For intravenous administration, Cefazolin is diluted with isotonic solutions, for example, 5% glucose solution or 0.9% sodium chloride solution.

How to dilute Cefazolin with novocaine

As a rule, adults are prescribed 1 gram of the drug per injection. In this case, you need to draw 5 milliliters of a 0.5% -1% novocaine solution into the syringe. Remove the protective foil from the bottle and carefully treat the rubber cap with a cotton swab soaked in alcohol. Novocaine must be injected into the bottle with Cefazolin, after which the bottle must be shaken several times until the drug is completely dissolved and the resulting solution must be drawn into a syringe.

How to dilute Cefazolin for children

As a rule, Cefazolin is prescribed to children at the rate of milligrams per 1 kilogram of body weight. for severe infections, the dose can be increased to 100 milligrams per 1 kilogram of the child’s body weight. For children, it is better to purchase bottles of 0.5 grams of Cefazolin, add 5 milliliters of novocaine to the bottle, the result is a solution containing 100 milligrams of the drug in 1 milliliter. If you need to inject 400 milligrams of Cefazolin (per 8 kilograms of a child’s body weight), you need to draw 4 milliliters of the resulting solution into a syringe.

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Cefazolin: how to dilute novocaine for injection for children and adults?

Of all the cephalosporin antibiotics, Cefazolin is the least toxic, and therefore quite safe, as far as it is possible to apply antibiotics. This antimicrobial agent has a wide range of uses, however, questions may arise with its direct use, since the drug requires preparation. How to dilute Cefazolin for children and adults? How to give his injections correctly?

Cefazolin: indications for use

This semi-synthetic antibiotic has an effect on most unicellular microorganisms, gram-positive and gram-negative bacteria. It remains in the blood plasma for 12 hours, reaching its highest concentration 1 hour after administration intramuscularly or intravenously. Used in case:

  • Staphylococcus, syphilis, gonorrhea, sepsis
  • Inflammation of the abdominal cavity
  • Infections of the biliary and urinary tract, musculoskeletal system, ENT organs, respiratory system
  • Blood poisoning
  • To prevent complications after surgery

Side effects are most often observed in people who have individual intolerance to cephalosporins and penicillins, but the body may react with increased sensitivity in the nervous system (convulsions), digestive, urinary and skin manifestations (itching, inflammation, swelling). With prolonged use, dysbacteriosis develops.

  • Due to the fact that the drug is excreted by the kidneys, for any pathologies of this organ, the use of Cefazolin should be agreed with the attending physician, and the dosage is always reduced, the drug is administered once to prevent its accumulation in the kidneys.
  • The drug cannot be used during pregnancy and lactation, as well as in children under 1 year of age, and in premature infants. The use of Cefazolin for intestinal diseases is undesirable.

How to prepare Cefazolin for injection: instructions

Since the main form of release of this antibiotic is powder, it requires preliminary preparation. Sterile water for injection is mainly used, but sometimes it is diluted with novocaine or lidocaine, thereby reducing the sensitivity of the injection area. When administered intramuscularly, the injection of Cefazolin is always painful.

  • When Cefazolin is administered intravenously through a dropper, 1 g of powder is dissolved in isotonic sodium chloride or glucose solution with a 5% concentration. Liquid volumeml. The duration of the procedure is 30 minutes; it is performed twice for an adult. Maximum dosage - 6 g.
  • When Cefazolin is administered intramuscularly, through an injection, 0.5-2 g of powder accounts for 3 ml of water for injection. Sodium chloride can also be used. For an intravenous injection, the volume is increased to 10 ml.
  • How to dilute Cefazolin with novocaine? For this purpose, a 1% solution of novocaine (or a lower concentration) is used; for 1 g of Cefazolin there is 5 ml of novocaine.

The system for diluting powder with liquid looks like this:

  1. The foil is removed and the lid is treated with medical alcohol.
  2. The liquid is poured into a bottle with powder.
  3. The bottle is shaken to dissolve the granules.
  4. The resulting solution is injected into a syringe.

How to dilute Cefazolin for children?

The dosage of this antibiotic for children should be prescribed by a doctor, but in a critical situation you can calculate it yourself and also give your baby an injection yourself.

  • For each kg of net weight, take from 25 to 50 mg of Cefazolin, depending on the sensitivity of the body.
  • A bottle of powder for children should contain 0.5 g of antibiotic for the most accurate dosage. At higher concentrations (1 g, 2 g), 10 and 20 ml of liquid are taken, respectively.
  • Water for injection or novocaine is also added to the bottle, and the required number of ml for administration is removed with a syringe.

The above instructions and recommendations for the use of Cefazolin do not replace consultation with a specialist. If any side effects occur, use of the antibiotic should be discontinued. Remember that Cefazolin solution can only be administered if it is completely clear.

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Features of the use of Cefazolin: indications, instructions and reviews

Cefazolin is a first-generation cephalosporin antibiotic, which is a semi-synthetic antimicrobial drug.

This drug has a negative effect on many pathogens.

Cefazolin is marketed as a powder for injection. Once the active substance enters the gastrointestinal tract, it disintegrates and does not have time to be absorbed into the blood, so the medicine is not produced in tablet form.

Due to its wide spectrum of action, the antibiotic is prescribed to treat many infections caused by microbes susceptible to the active substance.

The drug is used to treat the genitourinary and respiratory systems, for diseases of the skin, joints, and so on.

Composition and release form of the product

The main active ingredient of the antibiotic is cefazolin sodium salt.

The medication is produced in the form of a powder for injection solutions. The drug is injected into the muscle or intravenously. The powder is supplied to pharmacies in glass bottles of 0, 250; 0, 5; 1 grams.

Pharmacology of the drug

Cefazolin is a mildly toxic antibiotic. It is classified as an antimicrobial drug of semi-synthetic origin.

Medicines in this group kill infections and bacteria by destroying their cell membrane.

The antibiotic is active against many microorganisms. Not effective in the treatment of tuberculosis, fungus, viruses, protozoa bacteria, Pseudomonas aeruginosa.

Mechanism of action

The main therapeutic property of the drug is the destruction of pathogenic microorganisms that cause the development of an infectious-inflammatory disease.

Consequently, the antibiotic is prescribed to treat inflammation and infections caused by microbes sensitive to the active substance of the drug.

For what diseases is the drug prescribed?

Indications for use of Cefazolin:

  • genitourinary infections (cystitis, urethritis and others);
  • bronchitis (acute and chronic form);
  • inflammation, lung abscess;
  • peritonitis, endocarditis;
  • burn infections, osteomyelitis;
  • infections in the bile ducts;
  • infections of the joint apparatus;
  • skin diseases caused by pathogenic microorganisms;
  • infections of the reproductive system (gonorrhea, syphilis, sepsis, inflammation of the uterus).

Restrictions and contraindications

The drug is not recommended for use in the following cases:

  • during pregnancy and breastfeeding;
  • if there is hypersensitivity to drugs of the cephalosporin group;
  • children under one year old.

Rules of use and dosage

Depending on the treatment tactics and following the doctor’s prescription, the antibiotic is administered into a vein, muscle, or by drip.

For intramuscular injections, one bottle of Cefazolin (5 ml) should be diluted with water for injection solutions or isotonic sodium chloride solution. The antibiotic is injected deep into the muscle layer.

How to dilute Cefazolin correctly?

Since injections of the drug are quite painful, it is better to use anesthetics for the solution. Cefazolin powder for injection into the muscle layer is diluted with an injection solution, Lidocaine, Novocaine.

To prepare a solution for injection into the muscle, 2-3 ml of sterile water, lidacoin -0.5%, novocaine -2% are injected into a bottle with powder.

Then the bottle is shaken until a clear liquid is obtained. When administering the drug into a vein, a solution is prepared by diluting the powder in sterile water. In this case, there should be at least 10 ml of water.

The solution is prepared immediately before administration. A high-quality solution should not contain impurities, particles, turbidity, or sediment. It should be transparent or have a slightly yellowish tint.

Learn more about how to dilute antibiotics:

To treat kidney diseases, our readers successfully use Galina Savina’s method.

Dosage selection is the most important issue

The dosage and frequency of injections of the drug are prescribed taking into account the patient’s condition and the potential risk of infection.

Injections are placed in a part of the body with a well-developed muscle layer - shoulder, buttock, thigh. The drug is administered into a vein not only by injection, but also by drip.

The dosage of the drug is determined according to the patient’s condition and the severity of the disease.

Adults who do not suffer from renal failure are prescribed the drug in the following dosages:

  1. Mild infectious diseases caused by cocci - 1 gram of the substance every 12 hours, 0.5 grams every 8 hours. The daily norm is 2 grams.
  2. Acute forms of genitourinary infections without complications - 1 gram every 12 hours. Daily dose – 2 grams.
  3. Pneumonia formed due to pneumococci - 0.5 grams every 12 hours. 1 gram of the drug is administered per day.
  4. Severe forms of infections and moderate diseases - 0.5 grams every 6-8 hours. Per day – 3-4 grams.
  5. Infectious diseases with a risk to the patient's life - 1-1.5 grams every 6 hours. Per day – 4-6 grams.

It is allowed to increase the daily dose of antibiotic to 12 grams if there is a question of life and death. For people with kidney problems, a lower dosage is prescribed.

The individual dose of the drug and the number of injections are determined using the creatinine filtration coefficient, calculated using the Rehberg test.

Cases of overdose

An overdose of the drug in patients with chronic renal failure can cause:

  • neurotoxic effect;
  • increased vascular readiness;
  • convulsions;
  • tachycardia;
  • nausea;
  • vomiting

The antibiotic is removed from the body using hemodialysis or dialysis, but the second option is not as effective as the first.

An overdose is most often observed if the doses of Cefazolin, which are indicated in the instructions for use, are overestimated by 2 or more times.

In patients without any kidney problems, allergic reactions may occur. In this case, treatment with the drug should be stopped and desensitizing therapy should be carried out.

Possible side effects

The medicine may cause the following side effects:

  • gastrointestinal tract: nausea, loss of appetite, heartburn, vomiting, diarrhea, glossitis, pain in the abdominal area;
  • urinary system: increased levels of urea and creatinine in the blood;
  • an overdose of the drug can cause kidney dysfunction;
  • allergic manifestations: itching, skin rash, fever, spasm of the respiratory tract, increased levels of eosinophils in the blood.

In certain cases, nephritis may develop due to allergies, angioedema, joint pain, and anaphylactic shock.

What else to consider

The course of treatment with an antibiotic is usually 7-14 days.

Prescribing an antibiotic for less than five days is not effective, since the infection in this case may not be completely destroyed, and there is a possibility of developing a resistant type of microbes that are resistant to the medicine.

It is not recommended to use the medication for more than two weeks, since in this case the formation of resistant subgroups of pathogens is also possible.

You should avoid drinking alcoholic beverages for the entire period of treatment.

During the period of bearing a child, an antibiotic is prescribed only for strict indications, when there is a possibility of a threat to the life of the pregnant woman.

Babies older than one month are prescribed the drug at the rate of 0.1 grams per kg. weight, but not more than a day. The daily dose is divided into three to four injections.

Features of use with other medications

Simultaneous treatment with Cefazolin and loop diuretics may cause neutralization of tubular secretion of the antibiotic.

Combining medication and ethanol in one course leads to disulfiram-like reactions;

When treated with Probenecid, Cefazolin injections will not give the desired effect.

How does it work in practice?

By studying the reviews of patients and doctors who use Cefazolin in their practice, you can complete the overall picture about the drug.

Expert opinion

When treating with Cefazolin, it is necessary to take into account the likelihood of allergic reactions when used with other antibiotics of the cephalosporin group, as well as with penicillin drugs.

During a course of injections with the drug, positive results of glucosuric tests may be observed, which are not true, since the antibiotic cannot in any way affect the results of tests carried out by enzymatic methods.

Urologist Nikolai Valerievich

Word to the patient

The drug was prescribed to me for a sore throat when Amoxicillin did not bring the expected effect.

The only drawback of this treatment is pain during injections, but such a drawback can be tolerated for the sake of a quick recovery.

In general, the practical use of Cefazolin has proven its effectiveness and safety.

Side effects occur extremely rarely, in the case of existing individual intolerance to the active substance.

But it is worth noting that some types of pathogenic microorganisms are resistant to first-generation antibiotics and require treatment with drugs with a broader spectrum of action.

Purchasing and storing medicines

The antibiotic is available in the form of powder for injection in a glass bottle. Possible dosage – 0.25;0.5; and 1 gram of Cefazolin. the price depends on the manufacturer and the dosage of the bottle and starts from 70 rubles and above.

The drug should be stored in a place protected from sunlight and out of reach of children.

The permissible temperature is no more than 25 degrees. Storage duration is two years from the date of issue. The medicine cannot be stored in the form of a ready-made solution. Dispensed by prescription.

What to replace the drug with?

Analogs of Cefazolin are drugs with a similar active ingredient:

The information is provided for informational purposes only and does not constitute a guide to action. Treatment with Cefazolin is possible only for medical reasons and as prescribed by a doctor.

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2 comments

Thank you for the interesting article, it is written very informatively. But let me comment - diluting cephalosporin antibiotics for intramuscular use in solutions of novocaine, water for injection and others is not recommended. To effectively dissolve the antibiotic, it is recommended to use lidocaine in a 1% concentration of 3.5 ml, as it has a powerful analgesic effect. The drug belongs to the second generation of anesthetics, therefore it is more effective and safe in terms of the development of allergic reactions compared to representatives of the first generation of analgesics - Novocain. Referring to the chemical structure of analgesics of amide origin, Lidocaine penetrates better into body tissues and therefore causes greater pain relief compared to its predecessors from the group of esters, which are less soluble. To avoid side effects of the drug, consult your doctor before use. Before use, it is advisable to perform an allergy test to prevent possible adverse reactions in the form of individual intolerance to the components of the drug. All the best!

If you inject cefazolin with sodium chloride, what will be the effect?

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The drug "Cefazolin": how to dilute and use?

Antibacterial drugs are used for many diseases caused by pathogenic microflora. The choice of drug depends on which pathogen is in the human body. Unfortunately, this cannot be identified immediately, so the doctor often prescribes broad-spectrum antibiotics, that is, those that affect many types of microorganisms. One of the groups of such drugs are cephalosporins, which exhibit a rapid and strong effect on the pathogen from the first days of the disease.

Description

The antibiotic "Cefazolin" is a first-generation drug. This drug affects many microorganisms, including gram (+) and gram (-) pathogens. These include: staphylococci, streptococci, pneumococci, enterobacteria, E. coli, Proteus, etc. These types of pathogens cause most inflammatory processes in the body. They can affect any system: respiratory, cardiovascular, genitourinary, digestive. The drug is used by injection, having previously prepared a solution of Cefazolin. How to dilute and use the drug? Before you start using the medicine, you need to learn about the method of its preparation.

Dilution of "Cefazolin"

The drug is available in powder form, which is stored in bottles. Amount of medicine: mg or 1 gram. In order to give it a liquid form, it is necessary to mix Cefazolin powder with some solvent. How to breed? The drug can be mixed with water for injection, isotonic NaCl solution, glucose, and also with novocaine. The choice and amount of solvent depends on the route of administration (intravenous or intramuscular).

Indications for use

The drug "Cefazolin" is used for infectious diseases of almost all organs:

1. Respiratory system – pneumonia, lung abscess, pleurisy, pleural empyema.

2. Urinary organs – pyelonephritis, cystitis, ureteral infections, glomerulonephritis.

3. Digestive system – inflammation of the biliary tract, cholecystitis, peritonitis.

In addition, the antibiotic "Cefazolin" is prescribed for arthritis, mastitis, otitis, the spread of infection throughout the body - sepsis, burns and wound lesions of the skin. The drug is effective for specific diseases: syphilis, gonorrhea. As a prevention of inflammatory processes, the medication is used in preparation for operations and during the recovery period.

The drug "Cefazolin": how to dilute?

Depending on the disease, route of administration and age of the patient, different doses of the drug are used. The drug "Cefazolin" is diluted by introducing a solvent into a bottle of powder. For intramuscular injections, 5 ml of isotonic solution or water is used, for drip administration - ml of glucose or NaCl solution, for jet intravenous administration - 10 ml. How to dilute Cefazolin with Novocaine: inject 5 ml of solvent into the bottle with the drug, wait a few minutes, then shake thoroughly to form a homogeneous mass. It should be remembered that before use, you must consult with a specialist about how to use the antibiotic Cefazolin, how to dilute the drug and in what doses to use.

Source: http://www.syl.ru/article/138697/undefined

How to dilute cefazolin with novocaine

author: pharmacologist Antonova A.Yu.

Antibiotics have become a part of our lives, providing us with a cure for many infections. For example, cefazolin is a broad-spectrum antibiotic.

It is used for infections of the urinary and biliary tract, skin, soft tissues, bones and joints, sepsis, inflammation of the heart muscle, infected burns, and for the prevention of postoperative infections. It is widely prescribed by doctors, both adults and children, for infectious diseases of the upper and lower respiratory tract, such as otitis media, tonsillitis, bronchitis, pneumonia, etc.

Method of application and dosage of cefazolin for dilution

The antibiotic is practically not absorbed when taken orally, so it is prescribed only by injection. It is administered intramuscularly every 8 hours, as it maintains an effective concentration during this particular time. The daily dose for an adult is 1 - 4 g, depending on the severity of the disease, for children - mg/kg. Treatment lasts 7-10 days. On pharmacy counters, cefazolin is presented as a powder for injection solutions in bottles of 0.25; 0.5 and 1g. So, if the prescription says cefazolin 1 g twice a day, injected for a week, then you need to buy 14 bottles. A solvent is required for its preparation.

Novocaine is a popular solvent

Suitable solvents are: isotonic sodium chloride solution, water for injection or novocaine. Novocaine is more often used - a local anesthetic that reduces pain during an injection. It has been used in medical practice for a long time and is usually well tolerated. Sold in pharmacies in a concentration of 0.25%, 2 or 5 ml, 10 ampoules per package. Add 2-3 ml of novocaine to the antibiotic bottle and shake thoroughly. Thus, a ready-to-use solution of cefazolin is obtained for single use.

Treatment with cefazolin and its contraindications

When treating, it is necessary to take into account contraindications, possible interactions of the antibiotic with other drugs taken and side effects.

One of the possible side effects of the antibiotic is an allergic reaction, which can manifest itself in the form of redness, skin rash, urticaria, itching, bronchospasm, Quincke's edema, anaphylactic shock. Therefore, if you are hypersensitive to cephalosporins or penicillins, you should not use this drug, as well as cefotaxime, which is also a cephalosporin.

Other side effects (nausea, vomiting, diarrhea or constipation, flatulence, abdominal pain, dysbacteriosis, leukopenia, neutropenia, thrombocytopenia, thrombocytosis, hemolytic anemia) are less common. The drug is used with caution and under the supervision of a doctor if the functions of the kidneys, liver and intestines are impaired. It is not recommended to use simultaneously with diuretics (for example, furosemide). Incompatible with aminoglycosides (for example, gentamicin).

Contraindications are pregnancy, breastfeeding, children under 1 month of age.

Novocaine, in turn, rarely causes allergic reactions. A contraindication for the use of novocaine is hypersensitivity.

Thus, when using antibiotics to treat infectious diseases, you need to know exactly what dose to use, how to dilute it correctly, what unwanted reactions may occur, its interactions and side effects.

Dimexide compress with novocaine

author: pharmacologist Kovyarova L.S.

Most often, in the treatment of joint pain and manifestations of neurological osteochondrosis, either ointments with anti-inflammatory and analgesic properties or compresses (applications) are used. The latter have a more effective effect, since a kind of buffer is created under the napkin, from where the drug is absorbed into a certain point in the body gradually and over a long period of time. For the procedure to bring a positive effect, it is carried out daily for 5-10 days.

Suppositories with novocaine - use, contraindications and instructions

author: doctor Antonova A.Yu.

Hemorrhoids or varicose veins of the rectum are one of the most common diseases in our time. Novocaine suppositories are a drug widely used to treat this disease. This is due to their effectiveness, good tolerability and availability. Like any other medicine, novocaine suppositories have their own indications for use, contraindications, and side effects.

Is it possible to dilute cefotaxime with novocaine?

author: pharmacologist Antonova A.Yu.

Antibiotics have been used in medicine for more than 70 years, helping humanity recover from various infections. Cefotaxime (or its foreign analogue Claforan) is a representative of this group of drugs and has a wide spectrum of action.

Allergy to novocaine

author: doctor Lee V.V.

Novocaine is a local anesthetic, has moderate anesthesia activity, and also has a wide range of therapeutic effects. It does not allow impulses to be generated at the ends of sensory nerves, and creates obstacles to their conduction along the fibers of the nervous tissue. Due to the peculiarities of its chemical structure, i.e. Being a weak base, it is able to block Na channels. Inhibits polysynaptic reflexes.

Source: http://hirurgs.ru/content/kak-razvodit-tsefazolin-novokainom

How to dilute Cefazolin with Novocaine?

Cefazolin is an antibiotic that belongs to a large group of cephalosporin drugs. The medicine must only be administered by injection. If you take it orally, the active substances are very quickly destroyed in the gastrointestinal tract, without having time to penetrate the blood and have the required effect.

Can Cefazolin be diluted with Novocaine or Lidocaine, and what is the best way to do this?

This drug is intended for the treatment of various systems and organs. It fights diseases caused by bacteria. Before giving the injection, Cefazolin must be diluted with Novocaine, water or Lidocaine.

What exactly will be used for dilution does not matter. The antibiotic works equally effectively in any case. The main condition is to strictly observe all proportions.

How to properly dilute Cefazolin with Novocaine?

Cefazolin powder should be taken only in the dosage prescribed by a specialist. That is, if you need 0.5 g, you should take a bottle with 0.5 g of the drug, and not divide the gram package in half:

  1. Carefully break open the ampoule of 2% lidocaine.
  2. Take a sterile syringe, put a needle on it and insert it into the ampoule.
  3. Draw up the required amount of liquid. Typically, an adult patient is prescribed a gram of antibiotic for one injection. As a rule, this dose of Cefazolin akos is diluted with 5 ml of Novocaine.
  4. Remove the syringe from the ampoule and pierce the bottle with the antibacterial drug with it.
  5. After you pour Novocaine without removing the needle, shake the bottle to mix the substances.

A high-quality solution is transparent. There should be no lumps or impurities, sediment or cloudiness in it. It must be prepared immediately before use; it is not advisable to store diluted Cefazolin. Only in exceptional cases is storage in the refrigerator allowed for up to two days.

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Source: http://womanadvice.ru/kak-razvodit-cefazolin-novokainom

How to dilute cefazolin correctly: with novocaine or lidocaine?

QUESTION. Hello, I wanted to ask how to properly dilute cefazolin to give injections to a child’s buttock. My daughter is 7 years old. Its weight is 32 kg. The doctor prescribed an antibiotic to treat acute bronchitis. They offered to send us to the pediatrics department, but we refused hospitalization. They said that we could give the injections ourselves. But after we bought the drugs, it turned out that cefazolin was a powder. How and with what to breed it? Someone I know says it's lipocaine. At the pharmacy the seller said that it should be diluted with novocaine.

And one more important question. How much powder should I take from the bottle for 1 injection? In 1 bottle we have 0.5 g. Cefazolin. I will be grateful for prompt answers.

ANSWER. Dear Alya, we would not recommend that you give antibiotic injections to your child yourself at home. Are you sure that she is not allergic to this group of drugs? Will you be able to independently provide all antiseptic measures to prevent the development of a post-injection abscess? Perhaps you should consult with your doctor to replace the injectable drug with another one that you can use orally? It may also be recommended to seek out an experienced nurse.

We recommend that you listen to these tips. Well, a few instructions - how to dilute cefazolin and how to use it in your case.

  1. Before you begin directly injecting the drug into muscle tissue, make sure that your child is not allergic to novocaine, lidocaine or cefazolin. To do this, you need to dilute the contents of 1 bottle in 3 different liquids - lidocaine, novocaine and water for injection. On the inner surface of the child's forearm, make a small scratch with a sterile injection needle and lubricate it with one of the solutions. Wait 30 minutes. If no redness appears, it means that your child tolerates this combination well, and you can begin administering the drug.
  2. Be sure to have 2-3 ampoules with an antihistamine (suprastin, tavegil, diphenhydramine) in your home medicine cabinet. At the first signs of an allergic reaction to the administration of an antibiotic, it is necessary to give an intramuscular injection of an antihistamine and call an ambulance.

And now directly about the procedure for diluting cefazolin. For children, it is recommended to take a 0.5 percent solution of novocaine. This makes the injection less painful. If you are intolerant to novocaine, cefazolin is diluted with plain water for injection. You can buy it at the pharmacy. Before diluting, shake the bottle with powder thoroughly. The top foil cover is slightly turned to the side and treated with an alcohol solution. 5 ml of novocaine or lidocaine solution is drawn into a syringe and this amount is injected into a bottle with an antibiotic. The contents are shaken until a clear, slightly yellowish solution is obtained. In the case of your child, for administration, you should draw half of the resulting solution back into the syringe - 2.5 ml. The second part is left in the refrigerator for re-injection. Before administration, the solution should be warmed to the child’s body temperature.

Source: http://pediatriya.info/?p=2292

Cefazolin: how to dilute novocaine for injection for children and adults?

Of all the cephalosporin antibiotics, Cefazolin is the least toxic, and therefore quite safe, as far as it is possible to apply antibiotics. This antimicrobial agent has a wide range of uses, however, questions may arise with its direct use, since the drug requires preparation. How to dilute Cefazolin for children and adults? How to give his injections correctly?

Cefazolin: indications for use

This semi-synthetic antibiotic has an effect on most unicellular microorganisms, gram-positive and gram-negative bacteria. It remains in the blood plasma for 12 hours, reaching its highest concentration 1 hour after administration intramuscularly or intravenously. Used in case:

  • Staphylococcus, syphilis, gonorrhea, sepsis
  • Inflammation of the abdominal cavity
  • Infections of the biliary and urinary tract, musculoskeletal system, ENT organs, respiratory system
  • Blood poisoning
  • To prevent complications after surgery

Side effects are most often observed in people who have individual intolerance to cephalosporins and penicillins, but the body may react with increased sensitivity in the nervous system (convulsions), digestive, urinary and skin manifestations (itching, inflammation, swelling). With prolonged use, dysbacteriosis develops.

  • Due to the fact that the drug is excreted by the kidneys, for any pathologies of this organ, the use of Cefazolin should be agreed with the attending physician, and the dosage is always reduced, the drug is administered once to prevent its accumulation in the kidneys.
  • The drug cannot be used during pregnancy and lactation, as well as in children under 1 year of age, and in premature infants. The use of Cefazolin for intestinal diseases is undesirable.

How to prepare Cefazolin for injection: instructions

Since the main form of release of this antibiotic is powder, it requires preliminary preparation. Sterile water for injection is mainly used, but sometimes it is diluted with novocaine or lidocaine, thereby reducing the sensitivity of the injection area. When administered intramuscularly, the injection of Cefazolin is always painful.

  • When Cefazolin is administered intravenously through a dropper, 1 g of powder is dissolved in isotonic sodium chloride or glucose solution with a 5% concentration. Liquid volumeml. The duration of the procedure is 30 minutes; it is performed twice for an adult. Maximum dosage - 6 g.
  • When Cefazolin is administered intramuscularly, through an injection, 0.5-2 g of powder accounts for 3 ml of water for injection. Sodium chloride can also be used. For an intravenous injection, the volume is increased to 10 ml.
  • How to dilute Cefazolin with novocaine? For this purpose, a 1% solution of novocaine (or a lower concentration) is used; for 1 g of Cefazolin there is 5 ml of novocaine.

The system for diluting powder with liquid looks like this:

  1. The foil is removed and the lid is treated with medical alcohol.
  2. The liquid is poured into a bottle with powder.
  3. The bottle is shaken to dissolve the granules.
  4. The resulting solution is injected into a syringe.

How to dilute Cefazolin for children?

The dosage of this antibiotic for children should be prescribed by a doctor, but in a critical situation you can calculate it yourself and also give your baby an injection yourself.

  • For each kg of net weight, take from 25 to 50 mg of Cefazolin, depending on the sensitivity of the body.
  • A bottle of powder for children should contain 0.5 g of antibiotic for the most accurate dosage. At higher concentrations (1 g, 2 g), 10 and 20 ml of liquid are taken, respectively.
  • Water for injection or novocaine is also added to the bottle, and the required number of ml for administration is removed with a syringe.

The above instructions and recommendations for the use of Cefazolin do not replace consultation with a specialist. If any side effects occur, use of the antibiotic should be discontinued. Remember that Cefazolin solution can only be administered if it is completely clear.

Source: http://mednews.info/cefazolin-kak-razvodit-novokainom-dlia-inekcii-detiam-i-vzroslym/