What kind of drug is Ingavirin?

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Ingavirin

Description current as of 04/09/2014

  • Latin name: Ingavirin
  • ATX code: J05AX
  • Active ingredient: Pentanedioic acid imidazolylethanamide
  • Manufacturer: JSC "Valenta Pharmaceuticals", Russia

Composition of Ingavirin

  • pentanedioic acid imidazolylethanamide;
  • colloidal silicon dioxide, lactose, magnesium stearate, potato starch;
  • shell – titanium dioxide, dyes, gelatin, azorubine.

Release form

The antiviral drug Ingavirin is available in the form of blue or red capsules containing white powder and granules.

Tablets 30 mg (blue) and 90 mg (red) are available in 7 pieces in a blister, 1 blister in a cardboard package.

pharmachologic effect

It has anti-inflammatory, immunomodulatory and antiviral effects.

Pharmacodynamics and pharmacokinetics

First of all, the medicine has an antiviral effect. It acts against influenza virus types A, B, parainfluenza, adenoviral and respiratory sensitization infections.

The anti-inflammatory effect is manifested by suppressing the production of inflammatory cytokines and reducing the activity of myeloperoxidase.

For sore throat, influenza and other acute respiratory viral infections, the therapeutic effect manifests itself in the form of a reduction in the febrile period, a decrease in the level of intoxication, and catarrhal phenomena. Also, with its use, the total number of complications decreases, and the duration of the disease becomes much shorter.

The drug very quickly enters the blood from the gastrointestinal tract and is also distributed to the organs. 30 minutes after taking the drug, its maximum concentration in organs and blood is observed. It is not metabolized in the body and is excreted in the same form. Most (about 80%) of the drug is eliminated from the body within 24 hours. 77% of the drug is excreted through the intestines, the remaining part through the kidneys.

Indications for use

The antiviral drug Ingavirin is prescribed in the following cases:

Contraindications

The contraindications for tablets are as follows:

Can it be given to children? This medication is contraindicated in children and adolescents under 18 years of age.

Side effects

Side effects of the medicine can occur in very rare cases in the form of an allergic reaction.

Instructions for use of Ingavirin (Method and dosage)

The drug must be taken orally, regardless of meals.

Instructions for Ingavirin 90 mg for the treatment of influenza and acute respiratory viral infections: for 5-7 days, 90 mg should be taken once a day. It is advisable to start taking pills immediately when symptoms of the disease appear, no later than 1.5 days after the onset of the disease.

Directions for use for the prevention of influenza and ARVI: take 90 mg once a day for a week.

Before taking 90 mg of medication, be sure to consult your doctor about this.

How often can you take Ingavirin? This drug should be taken when the first symptoms of the disease appear, the course of treatment should be at least 5 days.

Overdose

The annotation for the medicine does not describe cases of overdose.

Interaction

Can it be taken with antibiotics? Scientists have not studied the interaction of the drug with antibiotics, so taking them together is not recommended.

Terms of sale

The drug is sold without a prescription.

Storage conditions

Store in a dark, dry place at a temperature not exceeding 25 °C.

Best before date

special instructions

Since the drug does not have a sedative effect, its use does not affect the ability to drive a vehicle or perform work that requires concentration and quick reaction.

Analogues of Ingavirin 90 mg

Which is better: Ingavirin or Arbidol?

Scientists conducted a study, the purpose of which was to compare the safety and effectiveness of Ingavirin compared to Arbidol. In patients taking Ingavirin, body temperature dropped faster, a decrease in symptoms of intoxication was noticed, and not a single case of complications was observed. Neither the patients taking Ingavirin nor the patients taking Arbidol had any side effects.

Which is better: Ingavirin or Amiksin?

These funds have a number of significant differences. For example, Amiksin is allowed to be taken from 7 years of age, while Ingavirin is only allowed from 18. Ingavirin is not compatible with any antiviral agents, while Amiksin can be taken with antibiotics and other medications. Ingavirin is prescribed for influenza and other types of acute respiratory viral infections, while Amiksin has a broader focus. Moreover, both drugs have very low toxicity. Thus, Ingavirin as a medicine for influenza for adults is more effective, and in case of illness with herpes, hepatitis, etc., Amiksin is recommended.

Which is better: Ingavirin or Kagocel?

Kagocel is also a children's drug; it can be taken by children from 3 years of age; in addition to influenza, this remedy is also used against herpes. It can also be used simultaneously with other medications and antibiotics. This drug is non-toxic and does not accumulate in the body.

Which is better: Lavomax or Ingaverin?

Lavomax, like Ingaverin, is used from the age of 18, but has a wider spectrum of action. This product is also compatible with antibiotics. Lavomax has a wider range of contraindications, since it contains lactose.

The average price of analogues ranges from 20 to 50 UAH, but you should look for a drug substitute not only based on price, but also on the therapeutic effect. All of the above analogues are cheaper than Ingavirin, however, before replacing Ingavirin with a cheaper analogue, look at reviews of analogues and be sure to consult a doctor.

Instructions for use of the medicine by children

Ingavirin is contraindicated for children and adolescents under 18 years of age, therefore there are no instructions for children for this drug.

Ingavirin and alcohol

The compatibility of Ingavirin 90 mg with alcohol has not been studied separately. However, with regard to the simultaneous use of the product with alcohol, the usual rules apply - this is strictly prohibited.

During pregnancy and lactation

The medicine is prohibited for pregnant women and breastfeeding women. If it is necessary to use during lactation, you must stop breastfeeding.

Reviews for Ingavirin

On various medical forums, the average rating given to this drug is 3.86 points out of 5. Many patients note the effectiveness and rapid action of the drug, but you can often find negative reviews that say that the drug not only does not help with the disease, but it also makes it worse. There are also reviews of this drug during pregnancy, however, it is worth noting that it is not recommended to drink this medicine during this period.

Reviews from doctors about Ingavirin 90 mg and other reviews from specialists boil down to approximately the same thing: each drug is prescribed individually, depending on the characteristics of the patient. When used correctly, Ingavirin quickly eliminates the symptoms of the disease and effectively fights the virus.

You can often find similar questions on the Internet: “Is Ingavirin an antibiotic or not?”, “Is it an antibiotic?” The clear answer to these questions is that this remedy is in no way an antibiotic. There is no article on Wikipedia about this drug.

Ingavirin price, where to buy

The average cost of Ingaverin in Ukraine is approximately UAH. In Moscow and Russia, the price for Ingavirin 90 mg varies from 390 to 482 rubles per pack.

You can buy Ingavirin in Moscow and find out how much it costs at any pharmacy in the city.

The average price for antiviral drugs is UAH.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Kazakhstan Kazakhstan

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BIOSPHERE

I was convinced from my own experience that ingavirin works.

Ingavirin has zero effect. Bullshit, not a cure for viruses. On the third day it only got worse, the temperature rose, there were no signs of bacterial infection (no green snot, no purulent discharge from the lungs). I wonder what the pharmacists themselves drink? Or they will never tell the truth.

The gastronterologist strongly recommended that I take ingaverin instead of antibiotics. The first time it helped literally in one day. The second time I drank for five days - to no avail! I had to take a course of antibiotics, I decided to take the risk for the third time, I took it for five days, the cough did not go away, my joints ached, in the evening the temperature was 38! I won’t buy the drug again for that kind of money and I don’t recommend it to others!

I am for ingavirin. I’ve already tested it on myself and my husband: the sooner you start taking it, the less you get sick. If I start drinking at the first symptoms, then on the third day I feel as energetic as I wasn’t sick. And it’s easy to drink, just one capsule a day – you won’t forget.

Today I took the sixth tablet, a strong cough did not go away, my nose was stuffy, and on the sixth day of taking Ingavirin, phlegm “ran” out of my nose in a stream, after 9 o’clock in the evening the temperature rises to 37.3, it’s freezing, tomorrow evening I will take the last, seventh capsule, I hope for improvement , otherwise you will have to take Kagocel. Apparently, Ingavirin is not my medicine.

Last year it really helped! Whatever I drank. And ingavirin helped, and very quickly. Now I’m lying here, I’m sick again and I’m testing this remedy for the second time. Let's see!

It turns out that we pay a lot of money for those components, healing substances that we do not need to recover from ARVI. But how then do they affect our body if we treat the flu with cancer drugs?

I never give ingavirin to children. The cold is a disease that can be defeated by one’s own immunity, even without taking useless dummies that have no proven effectiveness. Ingavirin is just that. There is no evidence of overdose or accumulation in the body. It is not known how treatment with such a drug will end.

My son came home from school with a fever and malaise, as well as a runny nose. I remembered that the doctor advised us to take Ingaverin, I ran to the pharmacy, took it immediately, rested for a day and went to school. My husband drank Kagocel, and after 3 days relief came.

Ingavirin did not help me. I started taking it with the first symptoms, didn’t miss a single day, but still didn’t see any benefit. I think its effectiveness is greatly exaggerated. Or someone really needs it to sell.

We also take Ingavirin as a family. Previously, my mother took other antiviral tablets, cheaper ones, but then she saw that my husband and I tolerated respirators much easier and last year asked her to also buy Ingavirin. And it’s very difficult to convince my mother of something new. What I like about Ingavirin is that it affects not only the influenza virus, but also many other viruses - when you just start getting sick, it’s difficult to understand by the first symptoms. For me, the hardest thing about taking Ingavirin is not missing the moment when you need to start drinking it. I try to do this - if I don’t feel well in the evening, then I wait until the morning; if the headache, body aches or other signs of the disease do not go away, I start taking Ingavirin. It works 100%, for the third year already. Thanks to Ingavirin, I began to take sick leave no more than twice a year, and then more for rest, but before I spent almost the entire winter on sick leave; not a single acute respiratory viral infection went away without complications.

Flu and colds cannot be treated with antibiotics, they can be treated with your own immunity, with the support of antipyretics, and no ingavirin is needed here. Because it does not act on the disease, but on the immune system, which is having a hard time even without Ingavirin. Such exposure can be hazardous to health and manifest itself in autoimmune diseases.

According to my observations, the use of ingavirin stops the disease very well. As soon as I feel like I’m starting to get sick, I immediately start taking these pills. And that’s it—the disease spreads no further. Flu, colds, acute respiratory infections - everything can be treated in one go. I am not a supporter of taking antibiotics, but this is a very good antiviral that works much better and without side effects.

No matter what anyone writes, Ingavirin works. The whole family has been taking it for a long time. Both for prevention and when we get sick. The effect varies. Sometimes it gets better the next morning, sometimes on the third day. Apparently, it depends on what stage of the disease you start taking it. But there was no such thing that it did not work. I also think that different medications affect everyone differently. Actovegin barely kept me alive, and then I was surprised to read that it helps many people. Therefore, I wish everyone to find their own medicines that will help them, and even better, not get sick.

Ingavirin is a normal drug. Helped me. It was kind of bad, like the flu. I went to the pharmacy myself, turning green. You can't even look at the tears. The pharmacist sympathized and recommended this remedy. I got over the flu in three days. I did not observe any pressure surges or problems with the gastrointestinal tract. I got sick over the weekend, so I didn’t even have to take sick leave.

Ingavirin did not help me, but on the contrary, my condition worsened and I had to call an ambulance. The doctor said that you are only triggering the disease by taking this drug, and it is better not to buy it for treatment.

The cold and flu virus mutates every year, and ingavirin is designed only for a specific strain of flu, so it’s not surprising that it doesn’t help.

it all depends on the body and what virus you caught

It's strange that there are so many negative reviews. For me this is a good remedy. Reduces fever, heals. If you compare how I was sick before and the last time with Ingavirin, heaven and earth. You don’t struggle with fever for a week, it’s all gone, but for just two or three days. On the fifth day the person is already healthy.

I decided to try ingaverin and started drinking it at the first sign. 1 capsule per day. The cold has passed - symptoms. But the pressure rose to 140 over 95. I think from this drug. And the heartbeat is strong. I'll stop drinking tomorrow. I'll watch.

I don't understand anything. I went to the very best therapist in the clinic, a wonderful doctor, competent, sensitive, she prescribed me Ingavirin for the flu and said that it can also be taken for prevention if you can’t get sick. There are such circumstances. Even the first time I didn’t feel bad from it, after three days I started to recover and went back to work. And I took it once for prevention, when everyone was sick at work, it helped, I didn’t get infected. It's as if different ingavirins are being discussed.

I don’t believe that Ingavirin doesn’t help, it’s the only thing that saves me when I’m sick. My attending physician recommended Ingavirin to me, and I completely trust him.

Despite the fact that experts from the Russian Academy of Sciences are sounding the alarm, speaking on Channel One, ingavirin continues to hold a leading position in the list of best-selling drugs in the winter months. Reviews by the Cochrane Library of Medical Research, respected by doctors around the world, do not contain any articles confirming its effectiveness. Ingavirin is not on the list of drugs recommended by the World Health Organization. No wonder it is not sold in Western countries. And only here it is still on the list of top sellers.

Ingavirin is a good antiviral drug. It eliminates all symptoms of the disease in 2 days. It has already helped 2 times, it’s a good medicine

An excellent tool. It helped quickly. Before this, Kagocel was prescribed. zero editorial, money down the drain.

It has long been known that ingavirin is on the list of the most useless drugs; is anyone still trying to be treated with it? I don’t even take risks, I have only one health, and I’m not going to conduct experiments on it.

I took Ingavirin, it didn’t help. Flu symptoms have only gotten worse, the medicine is a dummy

and INGAVIRIN helped my son! but KAGOCEL for mom - not so much! Artyom wrote it correctly - everything is individual! Everyone's body is different! One size fits all cannot be done. Some people like the priest and some like the priest’s daughter. On the second day my son already felt well. and my mother continued to receive treatment for a long time after Kagocel.

Unlike imported drugs, Ingavirin receives more negative reviews, but I choose it and it helps me.

Excellent drug! Always helps! If it doesn’t help someone, either they bought a fake, or the disease does not correspond to the medicine. For acute respiratory infections, acute respiratory viral infections - Ingaverin is the most reliable friend! After the second capsule - like born again. The main thing is to start drinking at the first symptoms. I saw it much later and also helped.

Don’t even think about buying a drug from the category - it’s money down the drain! I drank for five days, only worse. Possibly fake. I noticed that inexpensive domestic drugs are much more effective than expensive ones. There is no point in counterfeiters getting involved with cheap stuff; they would like to get more dough right away.

But the last time we got sick with the flu as a whole family, my husband and I and our children. We were treated with Ingaverin. After all, it has two actions at once - it eliminates the symptoms and kills the virus in the body. Helped quickly enough.

I took the drug as prescribed by the doctor. Thanks to the manufacturers! I read the reviews here and didn’t feel good before taking the medicine. I would like to ask many people: what century, gentlemen, do you live in? I live now in a city of millions. With my general illness, I can’t have a fever for more than a day. You can treat with viburnum and raspberries, but where can you get environmentally friendly ones in a huge city? So the medicine helped me 100%! It's antiviral! And additionally, depending on the temperature, I drank ibuclin twice. Teas with additives.

They prescribed it for a child with ARVI, started treatment immediately, but there was no help from him. The child had a fever for five days and had to adjust the treatment and take completely different medications. I definitely won’t buy it again, it’s absolutely useless.

My therapist prescribed Ingavirin to me when I had a cold, but I didn’t even take it. Why take a medicine that contains the same active substance as dicarbamine, which is used to treat cancer!! I don't think it's safe.

Ingavirin only relieves symptoms, but does not cure, I learned for myself when I came down with the flu and started taking Ingavirin. The symptoms were relieved, but the disease did not become any easier; on the contrary, it turned into bronchitis, which had to be treated with antibiotics.

I’m taking Ingavirin for the first time, the pharmacist from the pharmacy advised me. On the second day after taking it, I felt better. A huge human thank you to such pharmacists. I will recommend this drug to my friends and relatives!

What kind of help can you expect from a drug that has not undergone full placebo-controlled studies, which has no foreign analogues, and which is not used anywhere in the world?! It is unknown what to expect from such treatment.

Our local physician constantly prescribes Ingavirin, but the fact that it doesn’t help, and he doesn’t have an evidence base, doesn’t matter. I basically don’t buy it anymore. Waste of money.

All drugs are toxins in the body. One is treated, the other is crippled. Our local doctor never takes medicine himself, but prescribes it for us. He says that a temperature of up to 38 degrees is normal and should not be brought down so as not to harm the immune system. I took 2 capsules of ARBIDOL during a flu epidemic and fell ill for 2 days. I like TERAFLU better. And then viburnum, raspberries, and homemade apple juice especially helps. Heat the apple juice to 60-70, put the medic, raspberries in a thermos and drink a glass. And vitamins and treatment.

After taking Ingaverin for 7 days, the day after withdrawal, everything in my throat seemed to be swollen, my tongue did not rise, it hurt, I felt suffocated. I took an allergy pill, it began to go away, only two days later I felt nauseous.

It’s very strange that Ingavirin didn’t help, maybe you just delayed the treatment. Ingavirin always helps me, I’ve been using it for a very long time, as soon as I start to get sick I immediately run to buy it, it has never let me down.

INGAVIRIN IS A POISON, OR AT BEST A PLACEBO, IT HAD NO EFFECT THE ENTIRE FAMILY HAS NOT HELPED ANYONE, AND THERE IS PROBABLY HARM, BECAUSE OF CHEMISTRY, IT’S A VERY PITY THAT THEY ARE MAKING IN ON PEOPLE, ON OUR HEALTH, SUCH MONEY IS TAKEN, SCAMS YUGI!

I had high hopes for Ingavirin, when everyone at work started getting sick, I decided to take it as a preventive measure. I drank the package, but a week later I still came down with a cold. So I'm not sure about its effectiveness.

I took Ingaverin on the recommendation of a doctor when I was sick with ARVI. This drug helped me recover in just one week, all symptoms completely disappeared. I took it according to the instructions, one capsule a day, and after 2 days I felt relief; before that I was lying in bed all the time. So this drug quickly helped me get back on my feet, so I’m happy with it.

If antivirals were still being treated, they won’t cure, but if you just suppress the symptoms and alleviate the condition, it won’t take long for complications to develop. You still need treatment.

I think anyone can distinguish a bacterial infection from a cold, a bacterial infection is much more complicated, there is no longer any talk about antiviral drugs, it is so bad that most often you have to call an ambulance. You are lucky that ingavirin helped, but not for me, even a common cold I couldn’t overcome it, I’m afraid to imagine what would have happened if I had gotten the flu. I no longer use it for treatment.

For those who were not helped by the drug question, are you sure that you had a viral infection? Ingavirin will definitely not help with a bacterial infection. It helped me personally.

Yes, they are fooling us in the dark with all these ingavirins. People make money, some are big - those who produce, some are small - those who write reviews about “helped”. I've read so many reviews, I won't trust any more in my life. I gave the money, but did not receive treatment. But even in the pharmacy they signed it, it turns out that there is some kind of mutual responsibility. We need to return to traditional medicine, it is more reliable.

Although the pharmacy and doctors praise Ingavirin, I think it’s a dummy. I drank it according to the instructions, but it didn’t help at all. Maybe it was developed as an antiviral agent, but was not finalized. Didn't help at all, threw away money and nothing more. I don’t give any stars - zero, I could give a minus - I would gladly give it, it took a significant minus from my wallet.

Last week I felt worse. I immediately bought Ingavirin and took one a day. On the third day there was no fever, the runny nose and cough disappeared. I think that the product is simply excellent, it’s not for nothing that doctors recommend it.

Ingavirin appeared in a children's dosage, I bought it for my son, he is 12, it helped very quickly, just as it always helps me when I start to get sick

The annotation for the medicine does not indicate side effects, but they are present, dizziness and nausea when taken, there may be a slight rash, this appeared when I took it with a friend as a prophylactic.

Didn't let me get sick. It’s real - everyone at work fell ill - some ended up in the hospital - pneumonia. And I immediately started taking Ingavirin and was ill for literally three days - that’s all, the rest was the same - a slight runny nose. Main. that none of these terrible complications have attached themselves

The doctor prescribed this drug to me. From the first day of illness, I did not receive any special effect from the drug. In the first three days, the symptoms did nothing but increase. Over the next three days, things gradually began to “get better.” But the thing is, I recovered without Ingavirin using the same system before! I don’t see any point in taking it in the future.

This antiviral drug is too expensive and has zero effectiveness. I wanted to use it to cure the flu over the weekend so as not to take sick leave, but in the end I was out of commission for a week. Moreover, she was seriously ill, with a high fever, tears and congestion, and practically did not get out of bed.

The whole family was treated, it got even worse, you expect it to help, but you wasted time. This is not a “dummy” medicine at all.

The manufacturer of Ingavirin hides side effects! Judging by the instructions, there are none at all except for an allergic reaction, but this is far from true! After the 1st capsule I had a severe headache and worsening condition, after the 2nd I had a feeling of loss of balance, dizziness, very strong weakness, complete loss of strength. It was just terrible, of course I didn’t take the third and it was better. My message is to study as much information as possible about the medications you are going to take. So that it doesn’t turn out like me, I wasn’t alarmed that the side effects are not listed, which are contraindicated for people under 18 years of age (I’m older, but the fact itself is that the drug turns out to be quite dangerous), after 2 capsules I already read that the drug has little research, and judging by the many reviews I’ve read I am far from alone in whom the drug caused the effects I described. Be careful.

We bought the drug Ingavirin for an 8-year-old child, started taking it in the first two hours after the temperature began to rise (it was about 39 degrees), especially since the incidence of swine and non-swine flu in our region began to rise. The effect is immediate, believe it or not. no. Two days later, the child went to school without a single sign of ARVI. We, the parents, did not take Ingavirin - I, the pregnant mother, did not take the risk, and my husband thought that he would not get sick. As a result, we have been sick for the fourth day with complications.

But on the contrary, it helped me! I don’t know, if you follow the instructions and start treatment on time, there won’t be any problems - we’ve been taking treatment for three years with the whole family - an excellent drug! I recommend to everyone. As for allergies, almost any drug can cause them; you always need to be careful here, especially for allergy sufferers.

I started taking the drug on the first day, as soon as my temperature started to rise. I immediately felt an improvement, no additional symptoms appeared. I drank it for 7 days, as soon as I stopped taking it, my throat suddenly hurt, a cough and runny nose appeared, and shooting in my ear. The infection just lay low and took its toll. What is the point of this ingaverin, it would be better if the body itself fought and developed immunity, otherwise the disease only dragged on for at least another week.

I really want to ask the producers and those who sell it to everyone: “How can you hate people to such an extent. “It’s not clear who put Ingavirin on the market. It doesn't help at all, and can even hurt you. I drank for three days, to no avail, the cold just started to progress. What about the price. In short, for me it’s 500 rubles thrown away.

crap doesn't help

Ingavirin was also imposed. And in addition to Rinz. I started drinking at the first signs of flu. Only my throat was slightly sore. There's no point. When the temperature reached 39.5 I bought Paracetamol with aspirin, and things started to get better. In general, pharmacists sell bullshit for a lot of money.

I took it on the second day after the cough appeared. I drank for 6 days. Now I have a fever and all the flu symptoms. Ingavirin did not help, not only in treatment, but it turned out to be useless as a prophylactic agent. Useless medicine. But how it is presented and advertised!

Ingaverin helps turn on immune cells to produce gamma interferons, thereby coping with the virus, but if the bacteria have managed to “eat” your throat, you cannot do without antibiotics. But this does not mean that Ingaverin does not work, it works very well. Study medicine to reason

I took Ingavirin, the result was immediate, the effect was positive. Maybe each individually.

Konstantin, what's the point of such advice? Doctors simply benefit from the sales of Ingavirin. If he still helped so well, then there would be no price for him. And so. At first I thought that it was just not helping me because of some unknown characteristics of the body. But it turns out that its effectiveness has simply not been proven. Here is the answer to all my doubts.

In our city you can’t find Ingavirin in pharmacies, they’ve all been scooped up, it’s too bad the doctors “recommend” it

and I was recently “treated” with ingavirin for the flu. Well, of course, there was no effect, but I poisoned myself considerably. That’s why I think I felt even worse on the 3rd day after taking it.

In fact, medicine knows only a few drugs that can overcome viral diseases. And then, these drugs are highly specific. Since ingavirin does not have reliable studies, then it is not worth buying it.

The side effects to Ingavirin only indicate “allergies of varying severity.” They also write that he did not undergo full-fledged studies, because he was released “on the sly” during the swine flu epidemic.

I took this drug for several days, and only then found out that its active ingredient is very serious and you simply cannot take it without special indications, it is even dangerous! Well, how can you sell this to everyone? Of course, I immediately threw it away and won’t buy it again.

I took INGAVIRIN and KAGOCEL according to the instructions, but there was no relief from the disease; in the end, if complications arise, it is always necessary to be treated with antibiotics. These drugs are just a scam for money and a lot of money. I don't recommend it to anyone.

I took ingavirin many times, the effect is always immediate and positive, the main thing is to take it for five days and not quit right away, since the effect of instant recovery is deceptive if you do not take the course. I often combined it with alcohol, I didn’t notice any negative symptoms, it could only be a slowdown in the effect of the drug. All medications are of course selected individually.

I drank Kagocel - it feels like it has a support effect so that I don’t die. The condition itself did not improve much even after drinking a pack. I started taking ingavirin, immediately felt an improvement, and after 2 days I was healthy. In general, everything is individual

INGAVIRIN is a very bad medicine. On the 2nd day my teeth hurt, my head went numb, my tongue turned yellow and there was a bitterness in my mouth. I didn’t take anything other than ingaverine. Be careful when taking this drug

Andrey: Not a word is said about choosing the size of stockings according to a person’s parameters: height, leg size, etc.

Olga: For coxarthrosis of the 2nd degree, I have been injecting for 4 years at the rate (after 6 months), there is no improvement.

Victoria: I don’t put my daughter in a car without taking a Dramamine tablet. We already had it.

Nastja: Please tell me, is Fluconazole a hormonal drug?

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Source: http://medside.ru/ingavirin

Ingavirin

Ingavirin: instructions for use and reviews

Latin name: Ingavirin

Active ingredient: Pentanedioic acid imidazolylethanamide

Manufacturer: JSC "Valenta Pharmaceuticals", Russia

Update of description and photo: 11/14/2017

Prices in pharmacies: from 390 rub.

Ingavirin is an innovative antiviral drug with a unique mechanism of action and a wide spectrum of antiviral activity; its use within two days from the onset of the disease shortens the period of intoxication, fever and catarrhal symptoms, reducing the viral load and significantly reducing the risk of complications.

Release form and composition

The drug is produced in the form of capsules of size No. 2, with a white logo on the cap of the capsule in the form of the letter “I” inside the ring, filled with granules and almost white or white powder; Clumping of the filler is allowed, which can be eliminated under mild mechanical stress:

  • dosage 30 mg: blue (7 pieces in blister packs, 1 or 2 packs in a pack);
  • dosage 60 mg: yellow (7 pieces in blister packs, 1 pack in a pack);
  • dosage 90 mg: red (7 pieces in blister packs, 1 pack in a pack).

Composition per 1 capsule:

  • active ingredient: vitaglutam (pentanedioic acid imidazolylethanamide) – 30, 60 or 90 mg;
  • auxiliary ingredients: lactose monohydrate, potato starch, colloidal silicon dioxide (aerosil), magnesium stearate;
  • ink for applying the logo: shellac, titanium dioxide, propylene glycol.
  • 30 mg capsules: gelatin, titanium dioxide, dyes (diamond black, patent blue, crimson - Ponceau 4R, azorubine);
  • 60 mg capsules: gelatin, titanium dioxide, yellow iron oxide dye;
  • 90 mg capsules: gelatin, titanium dioxide, dyes (azorubine, crimson - Ponceau 4R and quinoline yellow).

Pharmacological properties

Pharmacodynamics

An antiviral drug with proven efficacy in preclinical and clinical studies against influenza viruses type A - A(H1N1), including swine flu A(H1N1) pdm09, A(H5N1), A(M3N2) and type B virus parainfluenza, adenovirus, RSV (respiratory syncytial virus). According to the results of preclinical studies, the drug is also effective against metapneumovirus, coronavirus and enteroviruses, including rhinovirus and Coxsackie virus.

Ingavirin accelerates the elimination of viruses, which helps reduce the duration of the disease and reduces the likelihood of complications. The mechanism of action of vitaglutam is realized at the level of infected cells by stimulating innate immune factors inhibited by viral proteins. During the experiments, it was established, in particular, that pentanedioic acid imidazolylethanamide increases the expression of the type I interferon receptor IFNAR on the surface of epithelial immunocompetent cells. With an increase in the density of interferon receptors, the sensitivity of cells to endogenous interferon signals increases. The process occurs with phosphorylation (activation) of the transmitter protein STAT1, which transmits a signal to the cell nucleus, inducing the activity of antiviral genes. In the presence of infection, the production of the antiviral effector protein M×A is stimulated, which suppresses the intracellular transport of ribonucleoproteins of various viruses, which slows down viral replication.

Vitaglutam increases the level of interferon in the blood to the physiological norm, stimulating and normalizing the reduced α- and γ-interferon producing ability of blood leukocytes. Activates the generation of cytotoxic lymphocytes, increases the content of NK-T cells, which have high killer activity in relation to cells infected with viruses.

The anti-inflammatory effect is achieved by inhibiting the production of key pro-inflammatory cytokines [tumor necrosis factor (TNF-α), interleukins (IL-1β and IL-6)] and reducing myeloperoxidase activity. It has been experimentally proven that the use of Ingavirin together with antibiotics enhances the effectiveness of therapy in the model of bacterial sepsis, including that caused by strains of staphylococcus resistant to penicillin. An experimental study of the toxicological effect of imidazolylethanamide pentanedioic acid showed a low level of toxicity and a high safety profile of the drug. According to the parameters of acute toxicity, Ingavirin belongs to class IV - “Low toxic substances” (lethal doses of the drug when determining LD50 during acute toxicity experiments could not be established).

Pharmacokinetics

When taking vitaglutam in recommended doses, it is not possible to determine its content in the blood plasma using available methods.

In experimental studies using a radioactive label, it was established that vitaglutam enters the blood quickly from the gastrointestinal tract and is distributed evenly throughout the internal organs. It reaches its maximum concentration in the blood and most organs half an hour after administration. The area under the concentration-time pharmacokinetic curve (AUC) of the liver, kidneys and lungs slightly exceeds the blood AUC of 43.77 mcg h/g, and the AUC value of the adrenal glands, spleen, thymus and lymph nodes is lower than the blood AUC. The mean retention time of the drug (MRT) in the blood is 37.2 hours.

With a 5-day course of taking capsules orally once a day, imidazolylethanamide pentanedioic acid accumulates in tissues and internal organs. The qualitative indicators of the pharmacokinetic curves after each administration were identical: a rapid increase in drug concentration immediately after administration with a further slow decrease by 24 hours.

Vitaglutam is not metabolized in the body; 77% is excreted unchanged through the intestines and 23% through the kidneys. Within 24 hours, up to 80% of the received dose is excreted: 34.8% - from 0 to 5 hours after administration and 45.2% - from 5 to 24 hours.

Indications for use

  • Ingavirin 30 mg: therapy of influenza virus type A and B, other acute respiratory viral infections (acute respiratory viral infections), including parainfluenza, adenovirus infection, respiratory syncytial infection in adults and children over 13 years of age; prevention of influenza virus types A and B, as well as other acute respiratory viral infections in adult patients;
  • Ingavirin 60 mg: therapy for influenza virus types A and B, other acute respiratory viral infections, including parainfluenza, adenovirus infection, respiratory syncytial infection in children 7–17 years old;
  • Ingavirin 90 mg: therapy for influenza virus types A and B, other acute respiratory viral infections (acute respiratory viral infections), including parainfluenza, adenovirus infection, respiratory syncytial infection in adults; prevention of influenza virus types A and B, as well as other acute respiratory viral infections in adult patients.

Contraindications

Absolute contraindications common to all forms of release:

  • period of pregnancy and lactation (breastfeeding);
  • lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
  • increased individual sensitivity to the components of the drug.

Capsules in dosages of 30 and 90 mg are contraindicated for use by children under 13 years of age when treating influenza virus types A and B and other acute respiratory viral infections, and by children and adolescents under 18 years of age for the prevention of these diseases.

Capsules at a dosage of 60 mg are contraindicated for use by children under 7 years of age and persons over 18 years of age (due to the inability of the drug in this dosage form to provide the intake of vitaglutam at a dose of 90 mg).

Instructions for use of Ingavirin: method and dosage

Ingavirin is taken orally; the effectiveness of the drug does not depend on food intake. It is necessary to start treatment from the moment the first signs appear, but no later than 2 days from the onset of the disease.

Recommended dosage when taking the drug once a day:

  • capsules in dosages of 30 and 90 mg: therapy of influenza and acute respiratory viral infections in adult patients - 90 mg each (1 piece of 90 mg each or 3 pieces of 30 mg each), in children 13-17 years old - 60 mg each (2 pieces of each 30 mg); prevention of influenza and ARVI after contact with infected persons for adults – 90 mg (1 piece of 90 mg or 3 pieces of 30 mg);
  • capsules in a dosage of 60 mg: therapy of influenza and acute respiratory viral infections in children 7–17 years old - 60 mg each (1 piece of 60 mg).

The duration of treatment is 5–7 days, depending on the severity of the condition, the duration of administration for preventive purposes is 7 days.

Side effects

Taking Ingavirin may in rare cases cause hypersensitivity reactions.

Overdose

To date, no cases of Ingavirin overdose have been reported.

special instructions

It is not recommended to take Ingavirin simultaneously with other antiviral drugs.

Impact on the ability to drive vehicles and complex mechanisms

The effect of the drug on the speed of psychomotor reactions and concentration has not been studied. But, taking into account the mechanism of its influence on the body and the profile of side effects, it can be assumed that it does not affect the ability to perform work of increased complexity, including driving.

Use during pregnancy and lactation

Due to insufficient data on the effectiveness and safety of the use of Ingavirin by pregnant and lactating women, its use is contraindicated during these periods. If it is vitally necessary to use the drug during lactation, breastfeeding should be interrupted.

Use in childhood

According to the instructions, Ingavirin is used in children according to indications.

Drug interactions

There is no data on drug interactions between imidazolylethanamide pentanedioic acid and other substances/drugs.

Analogs

Analogues of Ingavirin are: Lavomax, Arbidol, Amizon, Amiksin, Kagocel, Vitaglutam, Dicarbamin, etc.

Terms and conditions of storage

Store in a place protected from direct sunlight, at a temperature not exceeding 25 °C. Keep away from children.

Shelf life: Ingavirin 60 mg – 3 years; Ingavirin 90 and 30 mg – 2 years.

Conditions for dispensing from pharmacies

Available without a prescription.

Reviews about Ingavirin

Reviews about Ingavirin are common and have a wide variety of opinions. The average rating of the drug on medical forums on a 5-point scale is 3.86 points. Some patients talk about the effectiveness and quick action of the drug, but you can also often find negative reviews claiming that taking the drug does not alleviate the condition, but increases the manifestation of the symptoms of the disease.

Experts testify that if Ingavirin is used in accordance with the recommendations, it helps to quickly eliminate the symptoms of the disease and helps the body fight the virus more effectively.

Price for Ingavirin in pharmacies

Price for Ingavirin:

  • capsules 60 mg (children) 7 pcs. in packaging - from 350 rubles;
  • capsules 90 mg, 7 pcs. in packaging - from 410 rub.

Ingavirin capsules 60 mg for children 7 pcs.

Ingavirin 60 mg No. 7 capsules for children

Ingavirin caps. 60 mg n7 (for children 7+ years)

Ingavirin 60 mg n7 caps for children over 7 years old

Ingavirin capsules 90 mg 7 pcs.

Ingavirin caps. 90mg n7

Ingavirin 90 mg No. 7 capsules

Education: First Moscow State Medical University named after I.M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Ingavirin

Ingavirin is an immunomodulatory agent that has antiviral and anti-inflammatory effects. It is used to treat influenza A (A/H1N1 and its other modifications), as well as against the influenza B virus and other acute respiratory viral infections (adenovirus infection, parainfluenza, respiratory syncytial infection).

Therapeutic effectiveness for influenza is manifested in a shortening of the period of fever, a decrease in intoxication (headache, weakness, dizziness), catarrhal phenomena, a decrease in the number of complications and the duration of the disease in general.

Ingavirin: Instructions for use

  • Antiviral agent
  • Anti-inflammatory

Release forms

Capsules Ingavirin size No. 2 with logo. The contents of the capsules are granules and powder of white or off-white color with a creamy tint.

Active ingredient: Vitaglutam (pentanedioic acid imidazolylethanamide).

1 capsule contains (active ingredient):

Auxiliary ingredients: lactose monohydrate, potato starch, colloidal silicon dioxide (aerosil), magnesium stearate.

Ink for applying the logo: shellac, titanium dioxide, propylene glycol.

Packing: 7 pcs. in blister packs, 1 pack in a pack.

pharmachologic effect

Ingavirin has an antiviral effect and is effective against influenza viruses types A and B and adenovirus infection. In experiments in vitro and in vivo, it effectively suppresses the reproduction and cytopathic effect of influenza viruses types A and B, adenoviruses.

The antiviral mechanism of action is the suppression of virus reproduction at the nuclear phase, delaying the migration of newly synthesized NP virus from the cytoplasm to the nucleus.

The anti-inflammatory effect is due to the suppression of the production of key pro-inflammatory cytokines and a decrease in the activity of myepoperoxidase.

It has a modulating effect on the functional activity of the interferon system: it causes an increase in the interferon content in the blood to the physiological norm, stimulates and normalizes the reduced alpha-interferon producing ability of blood leukocytes, stimulates the y-interferon producing ability of leukocytes.

Causes the generation of cytotoxic lymphocytes and increases the content of NK-T cells, which have high killer activity against virus-transformed cells and pronounced antiviral activity.

Pharmacokinetics

Suction and distribution

The drug quickly enters the bloodstream from the gastrointestinal tract. Maximum concentrations of Ingavirin in the blood, blood plasma and most organs are reached after 30 minutes. The drug is excreted unchanged.

When taking a course of the drug once a day, it accumulates in internal organs and tissues. At the same time, the qualitative characteristics of the pharmacokinetic curves after each administration of the drug were identical: a rapid increase in the concentration of the drug after each administration 0.5-1 hour after administration and then a slow decrease by 24 hours.

The drug is not metabolized in the body and is excreted unchanged.

The main elimination process occurs within 24 hours. During this period, 80% of the administered dose is excreted: 34.8% is excreted in the time interval from 0 to 5 hours and 45.2% in the time interval from 5 to 24 hours. 77 is excreted through the intestines % of the drug and 23% through the kidneys.

Indications for use

Prevention and treatment of influenza A and B and other acute respiratory viral infections (adenoviral infection, parainfluenza, respiratory syncytial infection) in adults and children.

Dosage regimen

Ingavirin is taken orally.

Taking the drug does not depend on food intake.

The drug should be taken from the moment the first symptoms of the disease appear, no later than 36 hours from the onset of the disease.

For the treatment of influenza and acute respiratory viral infections

Adults: prescribed 90 mg 1 time per day.

Children from 7 to 17 years old: 60 mg 1 time per day.

Duration of treatment is 5-7 days (depending on the severity of the condition). The drug should be taken from the moment the first symptoms of the disease appear, preferably no later than 2 days from the onset of the disease.

For the prevention of influenza and acute respiratory viral infections after contact with sick persons

Adults (18+): prescribed 90 mg 1 time per day.

For children, Ingavirin is contraindicated for prophylaxis.

Duration of treatment: 7 days.

Side effects

Allergic reactions (rare).

Pregnancy and lactation

The use of the drug during pregnancy and lactation has not been studied. If it is necessary to use the drug during lactation, breastfeeding should be stopped.

Contraindications

Hypersensitivity to the components of the drug.

special instructions

Toxicological studies indicate low toxicity and a high safety profile of the drug (LD50 exceeds the therapeutic dose by more than 3000 times).

It has been established that the drug does not have a mutagenic or carcinogenic effect, does not affect reproductive function, does not have immunotoxic or allergenic properties, and does not have a local irritant effect.

Transport management

Does not affect the ability to drive vehicles and operate machinery.

The drug does not have a sedative effect, does not affect the speed of the psychomotor reaction and can be used by people of various professions, incl. requiring increased attention and coordination of movements.

Overdose

Cases of drug overdose have not been described.

Drug interactions

Ingavirin capsules enhance the antitumor effect of cytostatics.

In addition, pentanedioic acid imidazolylethanamide reduces the toxic effect of cyclophosphamide and its combinations with platinum drugs.

Concomitant use of other antiviral drugs is not recommended.

Ingavirin price

Prices vary in different cities and pharmacies. Prices are approximate as of November 2017.

Ingavirin reviews

Ingavirin is an excellent drug. I am sure that all negative reviews are custom-made. During the day the temperature remained at 38.2. The doctor who came to the house prescribed only 1 drug - ingaverin (and our therapist, our aunt, is very smart and attentive!). In the evening I drank and went to bed, in the morning there was no fever, my health improved significantly. I still have a severe sore throat and runny nose, but compared to the hellish pain throughout my body, high fever and terrible heartbeat, this is nothing. At this rate, I think I’ll completely recover in 2 days.

Ingavirin helped me when I had been suffering for two weeks and nothing was helping. Only then did it become clear that I had the flu. Despite the fact that with a completely normal throat and unstuffed nose, but with terrible cramps, bloating and pain in the abdomen, with nausea, headaches and general breakdown of the body with the absence of high fever.

My husband was treated a month ago, now I am being treated with Ingavirin. Helps! I lay with a temperature of 37.5-38.5 for three days. Then they called a doctor, after his appointment, I started taking Ingavirin. On the first day, the temperature rose to 39.2, then gradually began to decrease. Today is the 2nd day of taking the medicine, temperature is 36.4. Life is getting better.

I was prescribed Ingavirin for a slightly different reason, the temperature stayed for two and a half months at 37.2 - 37.4, went through many doctors, they just shrugged their shoulders. They prescribed a broad-spectrum antibiotic, but it didn’t help. They prescribed Ingavirin, to be honest, I didn’t believe in the result at all, but strangely enough, on the 4th day of taking the temperature it settled at 36.6. Believe it or not.

The incubation period of influenza usually lasts from several hours to 1-2 days, but can last up to 5 days. Then the period of acute clinical manifestations of influenza begins.

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