Dioxidine in the nose

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The use of Dioxidin in the treatment of children, is it worth instilling it into the nose?

“Dioxidin” has long established itself as an effective antimicrobial agent, which is often prescribed for purulent-infectious processes in adults.

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However, in pediatrics, due to toxicity, this medicine is used with caution. When a doctor prescribes Dioxidin to a child, the mother is interested in how such a drug acts on the child’s body and when its use is justified. Since the instructions for the medication do not contain information about the treatment of otitis media, runny nose, bronchitis and many other diseases with this drug, many parents begin to worry whether Dioxidin will harm the little patient. Not everyone knows how to put it in the nose correctly.

Release form

“Dioxidin” is currently available in several forms:

  • A solution that can be used externally or injected. It is produced in two concentrations. A lower concentration of the drug (0.5%) can also be injected into a vein. “Dioxidine” in this form is ampoules with a greenish-yellowish, odorless, transparent solution. One ampoule contains 5 or 10 ml of medicine, and one package includes 5-10 ampoules.
  • 5% ointment, which is used only topically. This drug is produced in tubes and jars that contain from 30 to 100 g of a greenish-yellow substance.

Compound

The main component of the drug is called hydroxymethylquinoxaline dioxide. Its 0.5% solution contains 5 mg per 1 milliliter, and the content in a 1% medicine is 10 mg/ml. The only excipient in this form is sterile water. In 100 g of ointment, the active substance is contained in an amount of 5 g and is supplemented with monoglycerides, nipagin, macrogol and nipazole.

Operating principle

The drug is an antimicrobial bactericidal drug, effective against pseudomonas, Proteus, Klebsiella, Shigella, staphylococci, clostridia and other microbes. The medication prevents DNA synthesis in the cells of such bacteria, which disrupts the formation of nucleotides and the structure of membranes, which leads to the death of microorganisms. The drug is especially effective under anaerobic conditions, as it stimulates the formation of reactive oxygen species.

Indications

In hospitals, Dioxidin is especially in demand for infectious purulent diseases. Intravenous injections (0.5% solution) are usually prescribed for purulent meningitis, sepsis and other life-threatening pathologies. However, injections of the drug are not used in childhood, since there is a high risk of overdose and the harmful effects of such a drug on the adrenal glands. Quite a lot of effective antibacterial agents are produced that are approved for children, even for infants and premature babies.

Local use of the drug is prescribed by dentists, urologists and surgeons. The medicine is administered for purulent pleurisy, pneumonia with abscesses, peritonitis, purulent cystitis or suppuration of the gallbladder. “Dioxidine” is used to wash deep wounds, as well as advanced trophic skin lesions and burns complicated by infection. External treatment with the drug (lotions, compresses) is also prescribed for pustular skin infections.

ENT doctors often prescribe Dioxidin into the nose, and ophthalmologists can prescribe this remedy into the eyes if bacteria have infected the conjunctiva. For sore throat, this medicine is used to gargle, and for purulent otitis media, it is dripped into the ears.

The reason for dripping the drug into the nasal passages is a prolonged runny nose, which cannot be treated with other means, including antibiotics of other groups. In this case, you can use the medication in the nose if the discharge is greenish in color and has an unpleasant odor, which indicates the bacterial nature of the disease.

Some mothers still use Dioxidin in their children’s noses. Why and why they do this can be found out in the following video.

Quite often, complex drops are prescribed, which contain Dioxidin, as well as vasoconstrictors, hormonal and other agents - for example, Dexamethasone, Xylene, Nazivin, Hydrocortisone. The recipe for such drops is selected individually for each patient. They are used not only for rhinitis, but also for adenoiditis, sinusitis, prolonged sinusitis or frontal sinusitis.

For purulent bronchitis, pneumonia or lung abscess, inhalations with Dioxidin can be prescribed, which are done with a nebulizer. This way the drug gets directly into the infected tissues and affects the pathogens. For such procedures, the medication must be diluted with saline solution.

At what age is it allowed to take

One of the contraindications noted in the annotation for “Dioxidin” is age under 18 years. In this case, the medicine can be used for children, but only if prescribed by a doctor who will verify the indications for such treatment and determine the required dosage. It is prohibited to drip Dioxidin into a child’s nose without consulting a pediatrician.

Contraindications

The medicine should not be used in the following cases:

  • If the child has individual intolerance.
  • If the adrenal function of a small patient is impaired.

In case of impaired renal function, the use of the medication requires medical supervision.

Side effects

Since the drug affects not only the DCN of bacterial cells, but also human cells, it is considered toxic, but such a harmful effect is not observed when the drug is used topically if the dosage prescribed by the doctor is not exceeded. In this case, treatment of the skin or mucous membrane with Dioxidin can cause an allergic reaction in the form of itching or dermatitis.

To avoid such a side effect, treatment should begin with a sensitivity test. The medicine is applied to a small area of ​​skin. If the medication is prescribed into the nose, then inject 1 drop into each nostril. If after 3-6 hours there are no negative symptoms, then the medication is used in the dose prescribed by the doctor.

Instructions for use and dosage

Injections into a vein of 0.5% Dioxidin are given only for serious indications and under the supervision of a specialist. Typically, this drug is used in cases of intolerance or ineffectiveness of cephalosporins, carbapenems and other effective antibiotics. Intravenous administration of the medicine is prescribed only by drip, and the medicine is administered into the cavities or bronchi using a syringe, drainage or catheter. The dose and regimen of such use of Dioxidin are determined individually.

For purulent wounds or burns, treatment with Dioxidin involves the use of tampons soaked in the solution. They are applied to cleaned wound surfaces and changed regularly. For such treatment, either a 0.5% or 1% solution can be used, but in some cases a more diluted liquid preparation is used. It is diluted with water for injection or saline to a concentration of 0.1-0.2%.

If you are going to drip 0.5% Dioxidin into the ear or nose, you should clean the nasal cavity or ear canal from pathological secretions. You can also rinse with saline solution or a preparation based on sea water. Next, the medication is administered in the dose prescribed by the doctor.

Usually 2-3 drops of a 0.5% solution are instilled into the nose (1-3 times a day). If any warning symptoms appear (for example, dizziness or itching), treatment should be stopped immediately. The duration of use of the drug is often 3-5 days. It is not recommended to use this product for longer than 7 days.

Inhalations for coughs with Dioxidin require dilution of 0.5% of the drug with saline in a ratio of 1 to 2, and 1% solution in a ratio of 1 to 4. For one procedure, take 3-4 ml of diluted medication. The child should calmly inhale this medicine through a nebulizer (for 5-10 minutes).

Overdose

A high dose of Dioxidin can damage the adrenal glands, causing dystrophic changes in the organ’s cortex. For this reason, it is very important to control the concentration of the solution and the dosage prescribed to children.

Interaction with other drugs

Dioxidin is compatible with many other medications, including antihistamines, antibiotics, anti-inflammatory hormonal drugs and others. In this case, the doctor must decide whether the drugs can be used simultaneously, taking into account the diagnosis and other factors.

Terms of sale

Since the use of the medication has its own characteristics and limitations, you can buy Dioxidin in a pharmacy only after presenting a prescription from a doctor. For 10 ampoules of the drug you need to pay about rubles, and the price of a tube with 30 g of ointment is about rubles.

Storage Features

  • The shelf life of the medicine in liquid form is 2 years, and the ointment is 3 years.
  • The optimal storage temperature for liquid “Dioxidin” is the range from 15 to 25 degrees Celsius.
  • The ointment should be stored at temperatures below +20 degrees.
  • If the storage temperature drops below +15, crystals may appear in the solution. Such a drug should be heated in a water bath so that all the sediment dissolves again and the medication itself becomes transparent.
  • An opened Dioxidine ampoule should be used immediately. If the medicine is used in the nose, then a new ampoule is opened each time for instillation. This can be avoided by pouring the medication from an open ampoule into a nasal drop bottle or drawing it into a syringe, and then measuring the required amount for one procedure.

Reviews

There are different reviews about the use of Dioxidin for children. In many of them, mothers confirm the good effectiveness of this remedy for purulent infections, and also praise the medication for its low cost and widespread availability. In other reviews, parents note the appearance of an allergy to such a remedy or the lack of a therapeutic effect.

There are also negative opinions from mothers who do not risk using Dioxidin for their child, fearing its toxic influence. They are supported by many pediatricians (including Dr. Komarovsky), preferring to prescribe antibacterial drugs approved for children in childhood, which are now produced by pharmaceutical companies in a wide range.

Analogs

A replacement for Dioxidin can be the drugs Dioxysept and Dixin, since they contain the same active substance and are available in the form of a solution used for both external treatment and injections. Instead of Dioxidin, other antiseptic and antibacterial agents can be used.

It can be replaced with “Miramistin”, the drug “Polydex”, “Protargol”, “Chlorophyllipt”, “Chlorhexidine”, “Isofra” and other medications that are prescribed for adenoids, runny nose, otitis media and other pathologies. Because they contain other active ingredients and may cause side effects, these medications should not be used without consulting your doctor.

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Source: http://www.o-krohe.ru/antibiotiki/dioksidin/

Dioxidine in the nose

One of the most unpleasant and fraught with complications diseases is a runny nose. It causes great discomfort and interferes with proper breathing both day and night. Not only children, but also adults suffer from this disease, sometimes without even thinking that a simple runny nose, which is not treated properly, can turn into sinusitis, and this disease is much more serious, and its consequences are much more severe.

In order to prevent such problems, you should make a choice in favor of reliable and proven means, which can confidently include Dioxidin.

The drug Dioxidin is a drug that has a wide spectrum of action. It successfully fights pathologies caused by all kinds of infections that enter the body in the form of pathogens such as streptococci, staphylococci, Pseudomonas aeruginosa and other pathogenic anaerobes.

Depending on how the disease manifests itself and how advanced the process is, Dioxidin is used externally and intravenously. The use of this drug for ENT diseases has proven its effectiveness. Its use helps to disinfect the nasal passages and sinuses, kill pathogens in the nasopharynx and bronchi.

You can drip Dioxidin into your nose without fear, since it does not irritate or injure the nasal mucosa, in comparison with other modern drugs. In addition, it is not addictive, which in turn is a huge advantage.

Action of Dioxidin

This drug is a powerful antiseptic and is used as nasal drops even when complicated by bacterial infections. Penetrating into the area of ​​the maxillary sinuses, it destroys bacteria that provoke the growth of infection. In this case, the runny nose ends or decreases. A complete list of drops for the common cold is presented here.

The effect of the drug is due to the presence of hydrocortisone, which has an anti-inflammatory, antiallergic, and decongestant effect. The use of Dioxidin can reduce treatment time and prevent complications.

It is worth noting that there are no special drops consisting of Dioxidine. This drug is available in the form of a 1 or 0.5% solution in 10 ml ampoules. Before use, you must open the ampoule and use a pipette for instillation. For children, this drug should be mixed with saline solution.

Use of Dioxidin in the nose for children

There is still debate that the use of this drug for children is unacceptable, since it is toxic and can harm the child’s body. And in large doses, Dioxidin even changes the structure of DNA. But the use of a 0.5% solution, which is instilled into the nose of children, is not dangerous and has a place in pediatrics.

In addition, some cases require the use of this drug, especially when it is justified by the long-awaited effect. Dioxidin is given to children when there are chronic purulent processes, while other means and methods do not bring the desired result. But in this case, strict dosage and compliance with the doctor’s recommendations is necessary.

The drug is often prescribed in a hospital setting, but if the instructions are strictly followed, every mother can use this drug to treat her child after consulting with her doctor.

It is important to remember that cotton swabs soaked in Dioxidin should not be placed in a child’s nose. Thus, you can seriously damage the mucous membrane and damage the villi, which will harm the child’s health.

Usually, before using the drug, the doctor recommends doing a bacterial culture in order to know exactly what pathogens provoked the problem and determine their sensitivity to the drug.

Referring to the test results, you can drip Dioxidin into the child’s nose, having previously diluted it with saline and previously cleared the nose of crusts and clots of mucus. The optimal course of treatment is 3-5 days. Apply 1-2 drops into each nostril 3 times a day.

Special attention is paid to the fact that diluted Dioxidin can be dripped into the ear for acute otitis media, when there is no improvement from treatment with other drugs. For otitis media, it is necessary to drip into both the nose and ears, while adhering to a schedule of no more than 2 times a day.

This drug can also be used in the treatment of cough using inhalation, but such procedures should be carried out only as prescribed by a doctor.

Dioxidin in the nose for adults

Often, a common runny nose causes serious complications, which occur not only among children, but also among adults. And one of the effective and powerful drugs that will help cope with the disease and prevent recurrence can be Dioxidin.

The medicine, which can be used in the form of drops, has proven itself in the fight against various types of rhinitis and sinusitis (read how to recognize it here). The course of treatment for adults can be from 3 to 7 days, depending on the severity of the disease and health status.

Place 2-3 drops into each nasal passage three times a day. For severe sinusitis, complex drops can be used, which, in addition to Dioxidin, also contain hydrocortisone and adrenaline. It is better to order these drops from a pharmacy or prepare them yourself, strictly following the instructions.

This solution is dripped into the nose, 1 drop up to 5 times a day. If there is some medication left in the ampoule and it was not possible to use it up in a day, it is not recommended to store the leftovers for more than a day. Only as a last resort, if the neck of the ampoule is securely closed, can you put it in the refrigerator and warm it a little in your hands before use.

In order for treatment with this drug to be effective and the course of therapy not to exceed the recommended 5 days, in addition to nasal drops, it is necessary to use other means and manipulations:

  • rinse the nasal passages at least 3 times a day with saline solution;
  • after consultation with a doctor and his approval, warm the nasal area if sinusitis is diagnosed;
  • wet cleaning of the premises and frequent ventilation are required;
  • the use of vitamin complexes, immunomodulators, herbal medicines;
  • air baths and hardening;
  • massage of active points, which help facilitate the release of mucus and reduce runny nose.

By following these simple recommendations, you can improve the body's resistance and prevent relapses of the disease.

Contraindications and possible adverse reactions

A drug such as Dioxidin has a number of contraindications for those people who suffer from allergic reactions or have an individual intolerance to the components of this drug. In addition, this medicine is not used to treat pregnant or lactating women, and is not recommended for young children.

In pediatric practice, only a diluted solution is used for instillation into the nose for runny noses and sinusitis. With treatment and compliance with dosage standards, the drug is well tolerated. But in some cases, certain adverse reactions may occur, which are manifested in the following:

  • increased body temperature;
  • dizziness, headache, nausea;
  • rash, itching and redness of the skin;
  • pain in the intestines, disruption of the gastrointestinal tract;
  • insomnia, convulsions.

If other symptoms are observed that worsen the general condition, then it is necessary to take any sorbent and stop taking the drug. Due to its side effects and existing toxicity, treatment with Dioxidin should only be carried out as prescribed and if all requirements are met. This is especially important when it comes to children, because any violation of the dosage and number of doses can cause serious consequences.

Dioxidine analogues

You can find analogues of this drug in the pharmacy chain. They are used in cases where there is an allergic reaction to the main component or there are contraindications.

  1. Dioxidin in the form of an ointment has an analogue, Dioxikol, which is also effective when used externally.
  2. The drug, which comes in tablet form, has a similar drug called Quinoxidine. Its use may cause disruptions in the gastrointestinal tract.

It is worth noting that the price in the pharmacy chain for this drug is quite affordable and differs only in the form of its release. Moreover, in order to take a course of 5 days, you do not need to purchase a whole package. This may only require a few ampoules.

Reviews after treatment with the drug

Reviews from patients who were treated with Dioxidin are mostly positive. There is a noticeable improvement in the condition, a decrease in symptoms of rhinitis and sinusitis, in some cases with advanced sinusitis there was a slight improvement. But in general, the drug proves its effectiveness when taken correctly and in compliance with the dosage.

Important Tips

Dioxidin is often prescribed in cases where no effect is observed from other drugs. To avoid adverse or allergic reactions while taking the drug, an additional antihistamine may be prescribed. In cases where severe adverse reactions occur, the drug is immediately discontinued. If, when storing Dioxidin in ampoules, the presence of crystals is observed, it is suitable for use, but before that it is necessary to warm it up in your hands or using a water bath, shaking the ampoule occasionally.

Before use, you need to make sure that the solution is completely transparent and the crystals have dissolved. You should not self-medicate and take the drug yourself, choosing doses individually.

Only a qualified doctor can prescribe medication and select the optimal course and dosage.

Dioxidin can be used in parallel with other drugs. And if the doctor prescribes it, then there is no reason to cancel previously started medication. To date, no negative consequences have been identified with combined use, as well as negative reviews or ineffective results.

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Treatment should only be prescribed by a doctor!

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Ampoules and drops of Dioxidin in the nose and ear - instructions for use, price

The instructions for use of Dioxidin indicate that this medication from the group of synthetic antibiotics has a broad spectrum of bactericidal action. Dioxidin exhibits particular activity against anaerobes, which makes it possible to use it in the treatment of severe purulent infections. In addition, the medication is included in the treatment regimen for diseases caused by anaerobic microorganisms and other strains of bacteria that exhibit resistance to other chemotherapy drugs.

The drug Dioxidin: description

Dioxidin is a synthetic antimicrobial agent with an active substance from the group of quinoxaline derivatives. In medicine, the drug is used in the treatment of infections caused by the following types of pathogens:

  • staphylococci, streptococci;
  • Pseudomonas aeruginosa;
  • klebsiella;
  • dysentery bacillus;
  • Vibrio cholera, Koch bacillus.

The drug exhibits high activity against anaerobic bacteria (including those that cause gas gangrene) and other pathogens of purulent-infectious processes. Obligate anaerobes exhibit particular sensitivity to the antibiotic, which makes it possible to prescribe Dioxidin in the treatment of pseudotuberculosis, shegellosis, cholera, and salmonellosis.

The action of the active substance, hydroxymethylquinoxaline dioxide, is aimed at suppressing the vital activity and destroying the cell membranes of pathogenic bacteria, which leads to their destruction.

When administered by injection, the drug can exhibit mutagenic and teratogenic effects, which limits its use and requires careful adherence to the recommended dosages during treatment. At a therapeutic concentration, the drug remains in the blood for 4 hours, reaching a maximum after 60 minutes. In this case, the active substance penetrates into all tissues and internal organs, but does not accumulate in the body with repeated administration. The drug is removed from the body through the urinary system (kidneys).

Varieties

Dioxidin has several forms of release:

  1. ointment 5%;
  2. Dioxidine solution (0.5%) for intravenous injection;
  3. Dioxidine in ampoules for inhalation (5 mg) and intracavitary use (1%).

Dioxidin ointment is intended for external use. 1 g of the drug contains 50 mg of active substance dissolved in a base of polyethylene oxide and other excipients. The ointment is sold in aluminum tubes of various volumes (from 25 to 100 mg).

Dioxidin 1% solution is available in 10 ml glass ampoules. 1 ml of a clear, colorless solution contains 10 mg of the active ingredient dissolved in water for injection.

Dioxidin 5 mg for inhalation is produced in ampoules of 10 and 20 ml. In each milliliter of the drug in water for injection, 5 mg of hydroxymethylquinoxaline dioxide is dissolved. Ampoules containing solution for injection and inhalation are placed in 10 pieces in cardboard packages.

When is Dioxidin prescribed?

In medicine, intravenous administration of the drug is practiced exclusively in hospital settings for the treatment of severe bacterial infections caused by microorganisms that are insensitive to other antibiotics. Since Dioxidin exhibits a toxic effect, during the treatment process it is necessary to monitor the patient’s condition and regular tests of vital signs. Intravenous injections are prescribed for the following conditions:

  • sepsis due to extensive burns;
  • purulent meningitis;
  • generalized purulent-inflammatory processes.

As a prophylaxis against bacterial infections, intravenous administration of the solution is recommended during cardiac surgery (coronary bypass surgery, vascular replacement).

Dioxidine solution (1%) is prescribed for the treatment of cystitis and purulent pleurisy, inflammation of the peritoneum (peritonitis), purulent inflammation (empyema) of the gallbladder. As a preventative measure, intracavitary injections are prescribed to prevent possible complications that arise during bladder catheterization.

Dioxidin ointment is used as part of complex therapy for trophic ulcers, purulent wounds (including osteomyelitis), extensive burns, purulent mastitis, infectious skin lesions (pyoderma) provoked by streptococcal or staphylococcal pathogens.

A 5 mg solution is used in otolaryngology for the treatment of rhinitis, sinusitis, by instilling Dioxidin into the nose, and is also included in the complex treatment of otitis media. Procedures using Dioxidin in the ear are prescribed for an inflammatory process associated with the penetration of bacterial agents into the hearing organs.

Instructions for use

Intravenous injections are done only with the use of a dropper, in a hospital setting and under the supervision of the attending physician. Before the procedure, it is necessary to do tests to determine the tolerability of the medication. For injections, the Dioxide solution must first be diluted with an isotonic sodium chloride solution to a concentration of 0.1 - 0.2%. A single dose of the drug should not exceed 30 mg, daily - 60 mg.

Dioxidine solution is injected into the cavity using a syringe, catheter or drainage tube. Taking into account the size of purulent cavities, from 10 to 50 ml of solution can be administered per day. If the patient tolerates the infusions well, the drug can be administered once a day for 3 weeks or more. In this case, the maximum daily dose cannot be higher than 70 ml.

External use

Photo: ointment for joint pain

For external treatment of superficial purulent wounds, gauze pads soaked in Dioxidin solution (0.5 - 1%) are applied. If the wounds are deep, tampons moistened with a 1% Dioxidine solution are placed into the cavities. For osteomyelitis, which is accompanied by the formation of deep purulent wounds on the hands and feet, baths with a solution are used or the drug is injected into the wound for minutes.

Dioxidin ointment is applied to previously cleaned superficial wounds or burns in a thin layer. Bandages with ointment are changed taking into account the condition of the affected skin (daily or every other day). The duration of treatment depends on the tolerability of the drug and the rate of healing. On average, the ointment form of the medication is used for 2-3 weeks. Repeated courses of treatment are prescribed by the doctor, taking into account the patient’s condition.

Dioxidin for children is often used in the treatment of purulent otitis and rhinitis. Before instilling the solution, the ear canal is thoroughly cleaned of sulfur secretions or pus using a cotton swab soaked in a 3% solution of hydrogen peroxide. Then Dioxidin is injected into the ear and at the same time into the nose, since these organs are connected to each other by the Eustachian tube. This procedure allows you to sanitize not only the ear canal, but also the nasal cavity, effectively eliminating the inflammatory process.

Instillation into the nose

Dioxidin instillation into the nose is used for complicated forms of rhinitis (runny nose). In pediatrics, the solution is pre-diluted to a concentration of 0.1-0.2%. The doctor must select a treatment regimen for children individually. The standard course of treatment involves administering 1-2 drops of solution into each nostril for 3-5 days. The procedure is done 2-3 times a day.

Dioxidin for adults with sinusitis is administered in a volume of 3 drops to 1/3 of a pipette. The exact dosage of the drug and frequency of use should be determined by the doctor. Before instillation into the nose, the drug is diluted with sodium chloride solution or water for injection.

Inhalation therapy is used in the treatment of respiratory diseases. To carry out the procedure, 1% medicine is diluted with physiological solution in a ratio of 1:4, a solution of 0.5% is diluted in a ratio of 1:2. For one session, it is enough to use 4 ml of the resulting solution, which is added to the water for inhalation.

Contraindications

The main contraindications to the use of the drug are the following conditions:

  • individual intolerance to the active substance;
  • period of pregnancy and lactation;
  • adrenal insufficiency;
  • children's age (up to 12 years).

Despite the fact that the instructions for the drug have age restrictions, in pediatrics the drug is still used even in young children strictly according to indications in cases where the therapeutic effect cannot be achieved using other medications. When treating rhinitis and sinusitis, children are prescribed only a weakly concentrated solution of Dioxidin for instillation into the nose.

Adverse reactions

In general, Dioxidin is well tolerated by patients. But with intracavitary use and intravenous administration, the following reactions may occur:

  • fever accompanied by chills;
  • headache;
  • sudden convulsive muscle contractions;
  • dyspeptic disorders (nausea, vomiting, diarrhea);
  • allergic reactions (up to anaphylactic shock).

Sometimes the use of the drug causes a photosensitizing effect, accompanied by the appearance of areas of pigmentation on the skin. Treatment with ointment may cause dermatitis and severe itching in the treated areas.

If age spots appear, the duration of administration of a single dose of the drug is increased to 1.5 hours, or the dose is reduced and antihistamines are prescribed in parallel.

Additional recommendations

When the temperature drops to 15 °C, crystals may form in ampoules with the solution. In this case, before use, they are heated in a water bath until the sediment is completely dissolved.

In patients with renal failure, it is necessary to reduce the dose of the drug and conduct regular laboratory monitoring of the patient's condition.

Before starting to use Dioxidin, a drug tolerability study must be carried out. To do this, a small volume (10 ml) of a 1% solution is injected into the cavities and the patient’s condition is monitored for 3-6 hours. If no side effects (chills, fever, dizziness) occur during this time, the drug can be used for a course of treatment.

Analogs

The following medications are structural analogues of Dioxidin:

The list of drugs with another active ingredient that provide a similar therapeutic effect includes such drugs as Monural, Galenophyllipt, Nitroxoline, Amizolid, Zenix, Dioxicol, Fosfomycin. The question of the advisability of replacing Dioxidin with analogue drugs is entirely within the competence of the attending physician.

Cost of the drug

The price of Dioxidin in the pharmacy chain depends on the type of drug and the pharmacists’ markup:

  1. Dioxidin ointment - from 300 rubles;
  2. Dioxidin solution 1% - from 350 rubles;
  3. Dioxidin solution 0.5% - from 320 rubles.

Reviews about the application

Patient reviews of the drug Dioxidin are quite contradictory. Some patients believe that this is a strong remedy that very effectively stops processes associated with purulent infections. Others say that the medication is toxic and often causes serious adverse reactions. At the same time, most negative opinions are found about the use of injection forms of the drug, while the local use of solution and ointment raises virtually no complaints.

The ointment form of the drug very well disinfects purulent and burn wounds, prevents their further infection and promotes healing without causing irritation or other negative consequences.

Reviews from doctors indicate that the use of Dioxidin in the form of injections is indicated only in severe cases, when the use of other antibacterial agents does not produce results. In this case, during the treatment process, the patient must be constantly monitored, and his condition must be monitored by laboratory methods.

The instructions for the drug do not contain any mention of the possibility of using Dioxidin solution in pediatrics. However, in practice, a weak concentration solution is used in the treatment of purulent rhinitis in children as a very effective remedy. In this case, the doctor must individually select a treatment regimen and this approach is considered completely justified, as it helps to cope with the problem in a short time.

I don’t know how justified the use of Dioxidin in children is. I know that this is a very toxic drug, which is prescribed to adults only in extreme cases. It has a very negative effect on the kidneys, and in children the functions of the adrenal glands are not yet fully formed and it is difficult to say what the consequences will be in the future.

At the age of 7, the doctor recommended that Dioxidin solution be dripped into the nose of my son for complications of rhinitis. But after reading the instructions for the drug, I refused to buy it. Now there are many medications that are not so dangerous and do not cause such adverse reactions. I think I did the right thing.

Review #2

Last year I almost lost my mother; she was in the hospital with purulent meningitis. Everyone knows what a serious condition this is, often leading to death. As far as I know, the treatment regimen included the drug Dioxidin, since no other antibiotics helped. And it was this remedy that helped cope with the infection.

Of course, it is not harmless and is difficult to tolerate, but the end justifies the means, and besides, other antibiotics are also toxic to the body. This drug was administered under medical supervision, and blood was taken for analysis every 2 days in order to notice any negative changes in time. In the end, it was this antibiotic that helped, and my mother left the hospital on her own two feet.

Review #3

I have a severe stage of varicose veins. My legs are covered with trophic ulcers, I practically cannot move. Only those who have encountered similar manifestations will understand what a terrible state this is. Doctors prescribed different drugs, but only bandages with Dioxidine solution really helped me.

This is a very strong antimicrobial drug that disinfects ulcers and prevents purulent complications. Gauze napkins soaked generously in solution were applied to the damaged areas and secured with a bandage. The procedures were done over 2 weeks. The condition improved significantly, the ulcers began to heal, then I treated them with Dioxidin ointment and healing went even faster. Now I only use this product, it helps very well.

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Source: http://glavvrach.com/dioksidin/

Dioxidin for a runny nose - how to take, side effects, reviews

When a runny nose occurs, many of us approach this problem differently. Some snot cannot be treated and they think it will go away on its own, while others, on the contrary, drip everything into the nose.

Such approaches to the treatment of a runny nose are fraught with allergic reactions, the occurrence of protracted inflammatory processes, and drying of the nasal mucosa. In treatment, as in life, there should be moderation in everything. Therefore, it is better to determine the right medication in the otolaryngologist’s office. There is a drug on the pharmaceutical market called dioxidin, which doctors use in the treatment of complicated runny nose.

Important! Every patient should know that dioxidin is not used for the following types of runny nose:

  • allergic;
  • vasomotor;
  • medicinal;
  • viral;
  • atrophic and hypertrophic;
  • traumatic.

Effect of dioxidin and indications for use

If you read the instructions for dioxidine, then the indications for use do not include diseases of the nasopharynx, and the drug is offered for the treatment of a number of other inflammatory ailments:

  • purulent wounds of various locations;
  • burns with an infected wound surface;
  • phlegmon;
  • pleurisy of purulent origin;
  • trophic ulcers;
  • peritonitis;
  • other purulent processes.

Dioxidin is an antibacterial agent that destroys a wide range of pathogenic microflora. It also affects pyogenic microbes. Often, dioxidin is highly effective in cases where other antibacterial agents have failed.

Therefore, the drug is prescribed only for pronounced purulent processes and severe forms of infection. Dioxidin successfully suppresses staphylococcus, anaerobes, Klebsiella, salmonella, streptococcal pathogens, Pseudomonas aeruginosa and other infections.

Despite the absence of indications for the treatment of runny nose in the instructions for the drug, ENT departments successfully use dioxidin in their work. Now, let's take a closer look at how dioxidin is used in practice to treat a runny nose.

Instructions for the use of dioxidin for a runny nose

As a result of the accumulated experience in using dioxidin, we present to your attention a detailed guide to using dioxidin for a prolonged runny nose.

What form of the drug can be used for nasal instillation?

At the pharmacy you can buy ampoules with 0.5 or 1% dioxidine solution. One ampoule contains 10 ml of medicinal solution. For each instillation, the solution must be fresh; it is not recommended to store open ampoules, but in practice, an ampoule is more often used during the day (enough for three instillations: morning, afternoon and evening). The ampoule must be stored in the refrigerator, after covering the open neck with a cotton swab.

Important! Ampoules with a 0.5% solution do not need to be diluted before intranasal (through the nose) administration, but a 1% solution should be diluted in a 1:1 ratio with saline or distilled water.

How to use dioxidin correctly?

Usually the drug is used externally, intravenously or injected into the lesion cavity. To treat a persistent runny nose, dioxidine is instilled into the nasal passages. When treating sinusitis, the drug is administered intracavitarily.

The ampoule with the solution is opened and the required dose of the drug is drawn into the pipette. The average dose for adults is 2-3 drops in each nostril three times a day; for children, 1-2 drops 2-3 times a day are enough. According to indications, the doctor prescribes the required amount of the drug in each individual case of treatment of prolonged rhinitis or sinusitis.

For the best effect of the drug, pre-wash the nasal passages with saline solutions: Aquamaris, Quix, Marimer and others. The saline solution is easy to prepare at home: for a glass of boiled water at room temperature, you need to take 3–5 grams of table or sea salt. Stir the contents thoroughly so that the salt crystals all dissolve. Then inject about 1 ml of solution into each nostril.

After rinsing, blow your nose, and after 3-5 minutes, drip the dioxidine solution. The course of treatment with dioxidine depends on the severity of the infectious process, but does not exceed a week.

Dioxidin shows high effectiveness in purulent processes, and the symptoms of the disease usually disappear within 3-4 days after the start of the medication. The drug is so powerful that all pathogenic flora die at lightning speed.

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Is there any harm from using dioxidine?

Dioxidin exhibits toxic activity and cannot be used for a long time. It has contraindications in the following cases:

  • pregnancy (due to teratogenic effects on the fetus),
  • breastfeeding;
  • individual intolerance;
  • severe diseases of the kidneys and adrenal glands.

When using dioxidin, side effects may also appear, such as:

  • hyperthermia (increased body temperature);
  • allergy;
  • dark spots;
  • chills;
  • stool disorder;
  • headache;
  • convulsive muscle twitching;
  • dermatitis (in cases of using dioxidine externally).

Such side effects appear with intracavitary and intravenous administration of the drug. To relieve them, antihistamines (suprastin, erius, claritin, others) and calcium supplements are used. In case of severe intolerance, the drug is discontinued.

When administered intranasally, side effects, as a rule, do not develop. Only in the case of treatment of sinusitis, when intracavitary lavage of the sinuses is performed, unpleasant side symptoms may appear.

Is it possible to use dioxidin for a runny nose in a child?

Many parents are wary of prescribing dioxidine, and this is justified. The instructions clearly warn that the drug is intended for adults only. But, despite such instructions, otolaryngologists still use dioxidin in children in the treatment of various types of runny nose.

Due to the fact that there is completely no information in the instructions for the use of dioxidin in childhood, as well as its use for a runny nose, parents should make a decision together with their doctor, weighing the pros and cons: to use the drug for treatment or not.

Practitioners speak positively about dioxidine and believe that its use is often justified. They did not notice any special complications or severe consequences during the treatment of the runny nose with dioxidine.

Dioxidin is often used for inhalation for the common cold, including for children. You need to start using this treatment method only with the permission of your doctor.

Can dioxidin be used in pregnant women?

Dioxidin has a teratogenic effect, and this can cause irreparable malformations of the fetus. Therefore, it is not recommended to use the drug during this period of a woman’s life, especially in the earliest stages of pregnancy (before the 12th week).

After reading the article, many wondered whether it is worth treating a runny nose with dioxidine if there are no clear instructions for use in this pathology.

You will have to decide for yourself. Although few patients study the instructions and more often trust the doctor’s experience.

The positive thing is that the drug has long been tested in practice and shows excellent results in the treatment of rhinitis. A negative feature is that there are no scientific conclusions on the use of dioxidin in ENT practice.

The ideal is not to let the disease progress and treat a runny nose without leading it to protracted forms and the development of sinusitis. Try to use traditional medicine and traditional drugs that have been effective in eliminating inflammation of the nasal mucosa for many years. And only in case of urgent need to resort to “heavy artillery” - dioxidin!

Patient reviews about the treatment of runny nose with dioxidine

The child fell ill 8 days ago, we do not attend kindergarten. On the 5th day of illness, a yellow-green color of snot appeared. The ENT prescribed dioxidine three times a day, 1 drop. After the fourth instillation, the snot became transparent and liquid, but has not yet completely gone away. Treatment is prescribed for three days, then again for a consultation with an ENT specialist. There is an effect. The child’s well-being improved before our eyes.

The child was treated for a runny nose with sinupret, protargol, and saline rinses. This state lasted for 10 days, and they began to miss school. They did a culture from the nose, the result was Staphylococcus aureus. The doctor prescribed a course of treatment for a runny nose: for five days, morning and evening, drip 2 drops of dioxidine into each nostril, and additionally drink rose hips and calendula infusion.

The throat and nose are my weak points; if I get sick, it’s at the highest level. The snot turns green, they have had punctures several times. The throat swells, hurts, and lumbago appears in the ears. The doctor at the clinic recommended the following treatment regimen:

  • rinsing your nose with a Humer three times a day;
  • instillation of dioxidin 2 drops three times a day;
  • Fenistil drops inside (10 drops three times a day).

This is the first time I have felt improvement so quickly from treatment. The swelling immediately went away, the snot became normal in color, and its quantity decreased significantly. I was satisfied with the treatment, it’s nice to see quick results.

All reviews are taken from medical forums, also leave your reviews if you have had experience using this drug!

How to treat rhinitis correctly

Inhalations for the common cold with dioxidine

And a little about secrets.

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Source: http://lor-explorer.com/lekarstva-ot-nasmorka/dioksidin-ot-nasmorka-kak-prinimat-pobochnye-effekty-otzyvy

Dioxidine

Description current as of 01/13/2015

  • Latin name: Dioxydin
  • ATX code: J01XX
  • Active ingredient: Hydroxymethylchinoxalindioxydum
  • Manufacturer: JSC “Biosintez”, Nizhpharm, Novosibkhimpharm, Moskhimfarmpreparaty im. ON THE. Semashko, Russian Federation PJSC “Farmak”, Ukraine

Compound

One milliliter of a 1% solution for external and intracavitary use includes 10 mg of hydroxymethylquinoxaline dioxide, as well as water for injection in a volume of up to 1 ml.

A milliliter of 0.5 percent solution for local, intravenous and intracavitary use contains 5 mg of hydroxymethylquinoxaline dioxide and water for injection as an excipient (in a volume of up to 1 ml).

A gram of Dioxidin ointment contains 50 mg, as well as excipient substances: polyethylene oxide 400, polyethylene oxide 1500, nipagin, propyl ester of paraoxybenzoic acid.

Release form

The drug has the following dosage forms:

  • Dioxidin solution 1% for intracavitary and local use;
  • Dioxidin solution 0.5% for local, intravenous and intracavitary use;
  • Dioxidin ointment 5%.

A one percent solution is available in 10 ml colorless glass ampoules, 10 ampoules in one package; a 0.5% solution is supplied to pharmacies in colorless glass ampoules of 10 and 20 ml; The ointment is packaged in tubes of 25, 30, 50, 60 and 100 grams.

pharmachologic effect

Dioxidin is a product from the group of synthetic antibacterial bactericidal drugs. The active substance of the drug belongs to the group of quinoxaline derivatives and is characterized by a wide range of pharmacological activity.

Pharmacodynamics and pharmacokinetics

The mechanism of action of Dioxidin is associated with the damaging effect of hydroxymethylquinoxaline dioxide on the cell walls of microorganisms, which ultimately suppresses their vital activity and leads to their death.

The drug is active against Proteus vulgaris, Friedlander's bacillus, Pseudomonas aeruginosa, pathogens of bacterial dysentery from the genus Shigella (Shigella dysenteria, Shigella flexneri, Shigella boydii, Shigella sonnei), salmonella, which is the most common causative agent of acute diarrhea (Salmonella spp.), Escherichia coli (Escherichia coli), staphylococci (Staphylococcus spp.), streptococci (Streptococcus spp.), which are the causative agents of food toxic infections of pathogenic anaerobic bacteria Clostridium perfringens.

Dioxidin is capable of affecting bacterial strains resistant to other antimicrobial agents (including antibiotics). In this case, the product does not cause local irritation.

The possibility of development of drug resistance of microflora to the drug cannot be excluded.

When administered into a vein, it has a small therapeutic breadth of action, which in turn presupposes strict adherence to the dosage regimen specified in the instructions.

Treatment of burned areas of the body with the drug, as well as purulent-necrotic wounds, allows you to accelerate the healing process of the wound surface, reparative (restorative) tissue regeneration, as well as their marginal epithelization, and has a beneficial effect on the course of the wound process.

Experimental studies have established that the drug is capable of having teratogenic, mutagenic and embryotoxic effects.

When used as a local remedy, it is partially absorbed from the wound or burned surface treated with it. It is eliminated from the body by the kidneys.

After injection into a vein, the therapeutic concentration of hydroxymethylquinoxaline dioxide in the blood remains for the next 4-6 hours. Plasma concentration after a single injection of the solution reaches a maximum after approximately 1-2 hours.

The active substance quickly and easily penetrates into all tissues and internal organs and is excreted by the kidneys. With repeated administrations it does not accumulate in the body.

Indications for use

Indications for IV administration of Dioxidin are:

  • septic conditions (including conditions developing against the background of burn disease);
  • purulent meningitis (purulent-inflammatory damage to the membranes of the brain);
  • purulent-inflammatory processes accompanied by symptoms of generalization.

Intracavitary administration of Dioxidin in ampoules is indicated for purulent-inflammatory processes occurring in the chest or abdominal cavity, including:

  • purulent pleurisy (pleural empyema);
  • peritonitis (an inflammatory process affecting the parietal and visceral layers of the peritoneum);
  • cystitis (inflammation of the bladder);
  • empyema of the gallbladder (acute purulent inflammation of the gallbladder).

Intracavitary injections can also be prescribed for prophylactic purposes to prevent the development of infectious complications after bladder catheterization.

Dioxidin is used as an external and local remedy:

  • for the treatment of burns, trophic ulcers and wounds (including deep and superficial, of various locations, infected and purulent, difficult and long-term healing);
  • for the treatment of wounds that are characterized by the presence of deep purulent cavities (for example, purulent pleurisy, soft tissue abscesses, phlegmon and pelvic abscesses, postoperative wounds on the organs of the urinary and biliary system, purulent mastitis, etc.);
  • for the treatment of infectious skin lesions (pyoderma) caused by the activity of streptococci or staphylococci.

Contraindications

The use of Dioxidin is contraindicated:

Side effects

Intracavitary administration and administration of Dioxidin into a vein may be accompanied by:

When Dioxidin is applied topically, periwound dermatitis and itching may occur in the area of ​​the body treated with the drug.

Instructions for use of Dioxidin (Method and dosage)

Instructions for use of Dioxidin in ampoules

Dioxidin is administered intravenously by drip. In severe purulent-septic conditions, the solution before administration is pre-diluted with an isotonic solution (5% dextrose solution or 9% NaCl solution) to obtain a concentration of 0.1-0.1%.

The maximum permissible single dose is 0.3 grams, daily dose is 0.6 grams.

In cases where the patient is indicated for external use of Dioxidin, the drug is used for packing deep wounds, as well as irrigating affected areas of the body.

After preliminary cleaning and treatment, deep wounds are recommended to be loosely tamponed with tampons soaked in a 1% solution.

If the patient has a drainage tube, he is advised to administer 20 to 100 ml of a 0.5% solution into the cavity.

Therapy of deep purulent wounds on the hands or feet with osteomyelitis involves the use of Dioxidin solutions (0.5 or 1%, as indicated by the attending physician) in the form of baths.

Special treatment of the wound surface within minutes is also allowed: the drug is injected into the wound for a specified time, after which a bandage with a 1% solution of the drug is applied to the affected area of ​​the body.

Treatment of superficial infected purulent wounds involves applying wipes soaked in a 0.5 or 1% solution to the wound surface.

It is recommended to repeat the procedure daily or every other day (the frequency of applications depends on the condition of the wound and the characteristics of the wound process). The highest daily dose is 2.5 grams. Treatment with Dioxidin is usually continued for up to 3 weeks.

For patients with osteomyelitis, as well as if the drug is well tolerated, in some cases treatment can be continued for 1.5-2 months.

If intracavitary administration of the drug is necessary, the patient should inject 10 to 50 ml of a 1% solution into the cavity daily through a catheter or drainage tube. The drug is administered using a syringe, usually once. In some cases, Dioxidin may be administered in 2 doses according to indications.

The course of treatment lasts from 3 weeks. If appropriate, it is repeated after 1-1.5 months.

The highest daily dose for intracavitary administration is 70 ml.

Instructions for use of Dioxidin in the ear

To treat otitis media, it is usually customary to use antibiotics and vasoconstrictor drugs. However, in cases where they are not effective, Dioxidin becomes the drug of choice, a feature of which is its effectiveness against anaerobic bacteria.

Before instilling the medicine, it is recommended to clean the ear canal from wax using a cotton swab soaked in a 3% hydrogen peroxide solution or special cotton swabs (for convenience, the auricle is slightly pulled back). If the ear is very dirty, leave the tampon with peroxide in it for about 5 minutes.

In case of purulent otitis media, which is often accompanied by perforation of the eardrum and discharge of pus, all purulent contents are first removed from the ear canal before instillation.

For otitis, Dioxidin should be injected simultaneously into the nose and into the ear canal. The solution effectively sanitizes the nasal cavity and stops the inflammatory process in it, and since the nose is connected to the ear by the Eustachian tube, relieving the inflammatory process in the nose has a beneficial effect on the situation as a whole.

The dose and frequency of instillations are selected individually in each specific case and exclusively by the attending physician.

According to the instructions for use, Dioxidin drops are prohibited from being prescribed to patients under 18 years of age. However, in some situations, when it is not possible to achieve an effect using other means, pediatricians prescribe the medicine even to small children.

Instructions for use of Dioxidin in the nose

Prescription of Dioxidna in ampoules into the nose is used when it is necessary to treat certain forms of rhinitis, as well as for sinusitis.

For the treatment of adult patients, the drug should be pre-diluted with NaCl solution, hydrocortisone or water for injection before instillation. Dosage in the nose for an adult - from 2 drops to ⅓ pipette. Dioxdin drops are dripped into the nose 3 to 5 times a day. More precisely, the dose and the required frequency of procedures are determined by the attending physician.

The maximum duration of treatment should not exceed 7 days. If after this period the patient does not show improvement, he requires careful examination and, based on his results, appropriate treatment.

There are no official instructions for the use of Dioxidin in the nose for children. However, if appropriate, doctors also use the drug to treat children. Before instilling Dioxidin into the nose, the solution should be diluted to a concentration of 0.1-0.2%. As in the situation with adults, the doctor selects the treatment regimen individually.

As a rule, Dioxidin is administered to a child's nose 1-2 drops 2 or 3 times a day for 3-5 (maximum 7) days.

Inhalations with Dioxidin for adults

Inhalation therapy is one of the main types of treatment for respiratory tract diseases.

To prepare a solution for inhalation, the medicine is diluted with physiological solution in a ratio of 1:4 for a drug with a concentration of 1% and in a ratio of 1:2 for a drug with a concentration of 0.5%.

For one procedure, 3 to 4 ml of the resulting solution is used. The frequency of procedures is 2 times a day.

Dioxidin ointment: instructions for use

The ointment is applied topically. It is recommended to apply a thin layer to the affected area of ​​the body once a day. The course of treatment is up to three weeks.

Overdose

In case of an overdose of Dioxidin, acute adrenal insufficiency may develop, which requires immediate discontinuation of the drug and the appointment of appropriate hormone replacement therapy.

Interaction

For patients with hypersensitivity to hydroxymethylquinoxaline dioxide, Dioxidin is prescribed in combination with antihistamines or calcium preparations.

Terms of sale

Storage conditions

Dioxidin is included in List B. It is recommended to store the medicine in a light-protected place, out of the reach of children. Optimum storage temperature°C.

Best before date

special instructions

Prescription of Dioxidin is resorted to only in cases where the use of other antimicrobial drugs (including carbapenems, fluoroquinolones, cephalosporins of the II-IV generations) did not produce the expected effect.

For patients with chronic renal failure, the dosage regimen should be revised towards a lower dose.

When administered intravenously, Dioxidin has a narrow therapeutic range, which requires constant monitoring of compliance with the recommended dosage regimen.

To prevent the development of side effects, treatment with Dioxidin is supplemented with the prescription of antihistamines and calcium supplements. If adverse reactions do occur, the dose is reduced and the patient is prescribed antihistamines.

In some cases, the occurrence of adverse reactions is a reason to discontinue the drug.

If pigment spots appear on the skin, the dose should be reduced, while increasing the duration of its administration (a single dose is administered over one and a half to two hours) and supplementing the therapy with antihistamines.

If crystals appear in ampoules with the drug during storage (usually if the temperature drops below 15°C), it is recommended to dissolve them by heating the ampoules in a water bath (the water should boil) and shaking them periodically until the crystals are completely dissolved.

The solution should be completely transparent. If, after cooling it to 36-38°C, crystals do not form, Dioxidin is considered suitable for use.

During the period of treatment with the drug, care should be taken when driving vehicles, engaging in activities that are potentially hazardous to health and life, as well as performing work that requires a high speed of psychomotor reactions.

Analogs

Dioxidin for children

The drug is not intended for the treatment of children and adolescents under 18 years of age. This contraindication is mainly due to the possible toxic effect of hydroxymethylquinoxaline dioxide.

However, in certain situations, when the expected benefit to the child outweighs the potential risks, the doctor may neglect this limitation. If Dioxidin is prescribed, treatment should be carried out in a hospital setting or under the constant supervision of the attending physician.

In pediatrics, Dioxidin solution is most often used to treat ENT diseases, mainly purulent forms of rhinitis or sinusitis. It is considered most appropriate to use a medicine with a concentration of the active substance of 0.5%.

In addition, the solution and ointment can be used to treat wound surfaces. A solution with a concentration of 0.5% is prescribed if the patient has deep lesions.

However, Dioxidin with such a dosage of the active substance should not be used for a long time. Therefore, as the condition of the wound improves, they switch to a 0.1% solution or ointment.

Dioxidin for a runny nose

The drug is not available in the form of nasal drops, therefore, before dripping Dioxidin into the child’s nose, the contents of the ampoule are diluted with a hypertonic solution to obtain a solution with a concentration of hydroxymethylquinoxaline dioxide of 0.1-0.2%.

It is recommended to administer nasal drops for children three times a day, one or two in each nostril, best after instilling vasoconstrictor drugs that reduce tissue swelling and facilitate nasal breathing. When carrying out the instillation procedure, the patient should tilt his head back so that the medicine penetrates as deeply as possible into the nasal passages.

It should be remembered that after opening the ampoule with the medicine, the solution is considered suitable for use within 24 hours. The maximum permissible duration of treatment for a runny nose is 1 week. However, most pediatricians recommend limiting it to 3-4 days.

In parallel with treatment with Dioxidin, it is recommended to use traditional methods of treating a runny nose (warm the nasal passages and rinse them with weak saline solutions) and monitor the air humidity in the room.

Dioxidine in the ear

Dioxidin instillation into the ear is indicated for severe forms of acute inflammation of the middle ear, in cases where the antibiotics prescribed to the child do not give the desired effect.

Before using the solution, it is recommended to thoroughly clean the ear from wax with a cotton swab.

The solution in ampoules is instilled into the ear twice a day. Moreover, for otitis media, the procedures are also supplemented with nasal drops.

The drug is not ototoxic and does not affect the auditory nerve.

Dioxidin for sinusitis

Dioxidine in ampoules is often used in the treatment of infectious processes localized in the paranasal sinuses. For sinusitis, the solution is used in the form of inhalations or as nasal drops. Drops are administered two or three into each nasal passage. The procedures are repeated 2 times a day.

To treat sinusitis, complex drops can also be used, which are prepared using solutions of dioxidine, adrenaline and hydrocortisone. Complex drops are administered one into each nasal passage 4-5 times during the day.

Compound drops are prepared according to a prescription prescribed by a doctor in a pharmacy or at home.

Dioxidin for inhalation

Reviews indicate that prescribing inhalations to children using Dioxidin solution can effectively treat persistent cough. In addition, the use of the medicine helps to disinfect the nasal passages and paranasal sinuses, provokes the death of pathogens in the bronchi and pharynx, and also eliminates nasal congestion and prevents the separation of purulent secretions.

It is recommended to do inhalations with Dioxidin for children using a nebulizer. As a rule, this method is used for persistent bronchitis that cannot be treated with other antibacterial drugs.

For inhalation, a 0.5% solution is prescribed. Before the procedure, it should be diluted with a hypertonic solution in a ratio of 1:2. The duration of inhalation is from 3 to 4 minutes. The frequency of procedures is 2 times a day.

Dioxidin for gargling

The advisability of using a solution for gargling is due to the ability of hydroxymethylquinoxaline dioxide to eliminate infection, clean the infected surface and accelerate the regeneration of the mucous membrane.

These features of the drug contribute to the healing process in case of purulent bacterial infections provoked by microflora sensitive to Dioxidin in case of ineffectiveness of other prescribed antibacterial agents or if they are poorly tolerated by the patient.

Rinsing with the solution is prescribed for pharyngitis, sore throat, tonsillitis, and only in severe cases when other drugs do not help.

To prepare a solution for rinsing, the contents of one ampoule of a one percent solution of Dioxidin are diluted in a glass of warm drinking water, water for injection or isotonic NaCl solution.

A small amount of liquid is taken into the mouth and, throwing the head back, gargle for a few seconds. After this, the solution is spat out, and rinsing is continued until the solution is completely used. The procedure is repeated three times a day.

The course of treatment with rinsing with Dioxidin solution is 5 days (unless otherwise recommended by the attending physician).

During pregnancy

The pharmacological properties of Dioxidin make its use unacceptable during pregnancy and breastfeeding.

The medicine can cause disruption of embryogenesis and negatively affect the development of the fetal nervous system. Absorbed from the surface of the mucous membranes into the systemic bloodstream, it is able to penetrate into breast milk, and through it into the child’s body.

Reviews about Dioksidin

Reviews about Dioxidin are quite contradictory. Most patients to whom it was prescribed describe the drug as a very effective remedy, especially for diseases accompanied by a purulent-septic process.

Negative reviews are due to the fact that the drug is quite toxic (its therapeutic dose is only slightly less than the toxic one), and its use is often accompanied by unwanted side effects.

Reviews of the ointment allow us to conclude that Dioxidin in this dosage form does not cause irritation to the skin, stimulates tissue healing and generally has a beneficial effect on the wound process, however, with prolonged use, microorganisms develop resistance to the drug.

Dioxidin is used primarily as a reserve agent, that is, its help is resorted to only in extreme cases.

The instructions clearly indicate that the drug is intended exclusively for the treatment of adult patients, but it is often used to treat otolaryngological diseases in children.

Despite the fact that Dioxidin does not have an evidence base that would confirm the safety of its use in pediatrics, nasal drops, according to reviews left on the Internet, are a fairly effective remedy for such forms of pathological runny nose as, for example, purulent rhinitis.

Meanwhile, Dioxidin is not included in the standards for the treatment of ENT diseases, and there is no official data on its use as nasal drops. Thus, when prescribing this drug to a child, both the doctor and parents (if they agree with the prescribed treatment regimen) act at their own peril and risk.

It should be noted that until now, the use of the medicine has not been associated with any complications or negative consequences for the child’s body.

Dioxidine price, where to buy

The price of Dioxidin differs depending on the form of release of the drug. For example, the average price of Dioxidin in ampoules with a concentration of hydroxymethylquinoxaline dioxide is 0.5% (this form is used to prepare nasal drops) is rubles.

The cost of packaging ampoules with a 1% solution is from 327 to 795 rubles (depending on the manufacturer and the number of ampoules in the package). Ointment for external use can be purchased for approximately 285 rubles.
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BIOSPHERE

I realized that ointment is better

I bought your Deodesin for inhalation, but have not used it yet, unfortunately, the percentage is not indicated on the packaging and in the instructions and a mere mortal needs to look for a specialist to dilute it, but we don’t have specialists, only the Internet.

Diets.Guru: If the stage of the disease and the patient’s condition allow the possibility of surgery.

Kostya: Yesterday I picked up the child from kindergarten, came home and then it all started! At first the boy complained.

Artyom: Guys, hello! After all, there is Relium and Sibazon - these are Polish and Russian analogues, also.

cold lady: First of all, I liked the product, the price - less than 100 rubles in our pharmacy! And secondly .

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/dioksidin