What to take after Lazolvan

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Correct use of Lazolvan is the key to successful treatment

Everyone knows that medications should be used only as prescribed by a doctor. But very often we do not comply with this unconditional requirement and are treated with medications on the advice of friends, relatives or neighbors and a colleague.

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And this is very wrong. After all, even medicines for cough, which suffers from common colds, must be used correctly! For example, the correct use of Lazolvan is prescribed in the instructions, and a doctor should prescribe this medicine for treatment.

How does Lazolvan work?

The drug Lazolvan, widely advertised as a cough remedy for adults and children, belongs to the pharmacological group of secretolytics and stimulants of motor function of the respiratory tract. The active ingredient of this medicine is ambroxol, a metabolite of bromhexine.

By the way, when taking cough medicines based on bromhexine or its metabolites, we do not think at all about the fact that the natural substance vasicin was originally obtained. It was isolated from the medicinal plant Adhatoda vasica or Justitia vasica. And only then was a similar substance synthesized artificially, called bromhexine.

Bromhexine works well for the removal of sputum, but one of the side effects that it has during treatment is a decrease in the secretion of surfactant - a surfactant in the alaeoli of the lungs, which prevents them from sticking together. This can be very dangerous. Therefore, pharmacists, continuing to study bromhexine, found its derivative substance - the metabolite ambroxol. Ambroxol is the active ingredient in many medications taken to treat coughs with sputum that is difficult to separate. Ambroxol has a mucolytic stimulating effect, i.e. protective, activity by action. But unlike bromhexine, ambroxol does not have a negative effect on the surfactant of the lung alveoli.

A video advertisement will tell you how the drug Lazolvan works.

Lazolvan contains ambroxol as an active ingredient and auxiliary components, depending on the form of release of the drug. This drug thins mucus and also improves its elimination. The peculiarity of this drug is that it thins sputum without significantly increasing its volume, like some other cough medications. This is a definite plus in treatment, since it is easier for the body to excrete a smaller amount of sputum with a thinner consistency.

How to take Lazolvan?

The cough medicine Lazolvan is available in the following dosage forms:

  • pills
  • syrup
  • solution used both for oral administration and inhalation

The drug has high absorption - 80-90%, depending on the form of application for treatment. Lazolvan is an active drug. After only half an hour of taking or using the drug for inhalation, it begins to act, which affects the improvement of the patient’s condition, the effect lasts from 6 to 12 hours.

The active ingredient ambroxol penetrates the blood-brain barrier, the placental barrier and into breast milk, so its use should be careful during pregnancy or breastfeeding.

Lazolvan is prescribed by the attending physician for use in the treatment of respiratory diseases accompanied by poor separation of viscous, thick sputum. Such diseases include:

  • pneumonia or pneumonia
  • bronchitis in both acute and chronic forms
  • chronic obstructive pulmonary disease (COPD)
  • bronchiectasis
  • bronchial asthma with difficult to separate sputum

Lazolvan is not recommended for treatment of liver or kidney diseases, and it is also contraindicated for use in the first trimester of pregnancy. In the second and third trimesters, as well as during lactation, this drug should be taken only as prescribed by the attending physician.

This drug increases the effect of certain types of antibiotics, such as amoxicillin, doxycycline, erythromycin. It is not recommended to take it together with drugs that inhibit the activity of the cough center, since the sputum liquefied by Lazolvan will be difficult to clear.

The doctor prescribes the treatment!

Even if the patient is absolutely sure of it. that the cough arose against the background of a cold, and it should be treated, for example, with Lazolvan, you should definitely consult a doctor! Firstly, in order to accurately establish the cause of the cough, and secondly, only a doctor, after examining and studying the test results and making a diagnosis, will be able to prescribe adequate treatment with the necessary drugs. The same applies to the drug Lazolvan. The doctor will prescribe both the dosage of the drug and the regimen of use. By the way, Lazolvan is not recommended to be taken for longer than 5 days. further treatment with Lazolvan should be recommended by a doctor under constant monitoring of the course of the disease and the patient’s condition. If Lazolvan solution is used as inhalation to treat cough, then in this case you should know and remember that it contains non-alkonium chloride, which can cause bronchospasm.

The drug is available from pharmacies without a prescription, but it must be taken only on the recommendation of the attending physician. Lazolvan is stored in places inaccessible to children at temperatures not lower than 0 and not higher than 30 degrees Celsius.

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Source: http://doctoram.net/content/pravilnoe-primenenie-lazolvana-zalog-uspeshnogo-lecheniya.html

Lazolvan solution for inhalation, instructions for use

The drug is suitable for the treatment of adults and children. Before you start using the medicine, it is recommended to consult your doctor.

Compound

The active ingredient of Lazolvan is ambroxol hydrochloride.

Quantitative content of the active substance for each dosage form:

  • Syrup – 30 mg per 5 ml of the drug, children’s syrup – 15 mg per 5 ml.
  • Lazolvan solution for oral administration and inhalation contains 7.5 mg of active substance per 1 ml.
  • Tablets – 30 mg per 1 piece.
  • Lozenges – 15 mg per piece.

The active ingredient of the nasal spray is tramazoline hydrochloride.

Dosage forms

A wide selection of dosage forms of the drug allows you to find a suitable remedy for all categories of patients:

  • Nasal spray Lazolvan is a vasoconstrictor that is prescribed for the treatment of diseases of the ENT organs. The drug is a clear, pale yellow liquid with a characteristic odor of eucalyptus.
  • Lazolvan solution for oral administration and inhalation is a clear, colorless or slightly brown liquid. During inhalations with Lazolvan and saline solution, the dosage and duration of the course of therapy are selected individually.
  • The syrup is a viscous, transparent, colorless liquid that has a characteristic strawberry smell. Lazolvan syrup is not used for inhalation. The dosage form is intended for internal use.
  • Tablets for internal use.
  • Lozenges for resorption.

Indications and contraindications

An inhalation solution for children and adults is prescribed as part of complex therapy for the following diseases:

  • Pathologies of the upper respiratory tract in acute and chronic form, accompanied by increased secretion of sputum.
  • Bronchitis (acute and chronic form).
  • Pneumonia.
  • Chronic obstructive pulmonary disease.
  • Bronchial asthma, in which the process of sputum discharge is difficult.
  • Bronchiectasis.

Inhalations with Lazolvan during pregnancy should not be carried out in the 1st trimester. Another contraindication is intolerance to the active or excipients of the drug.

Instructions and dosage

Rules for taking the drug depend on the form of release.

Lazolvan Rino

Nasal drops Lazolvan are used to eliminate:

  • swelling and congestion of the nasal mucosa caused by acute respiratory infections or hay fever;
  • sinusitis and otitis media - in order to facilitate the outflow of the contents of the paranasal sinuses.

Instructions for using Lazolvan nasal drops indicate that adults and children over 6 years of age are recommended to take up to 4 injections of the product into each nostril over 24 hours. Duration of treatment – ​​up to 7 days.

Lazolvan Rino should not be used for patients under 6 years of age, with intolerance to the components of the drug, angle-closure glaucoma, atrophic rhinitis, or a history of surgical operations on the cranial area, which were performed through the nasal cavity.

Syrup Lazolvan

Lazolvan children's syrup (15 mg/5 ml) must be taken in accordance with the dosage regimen specified by the manufacturer:

  • Children under 2 years old - 0.5 teaspoon twice a day.
  • 2-6 years - 0.5 teaspoon three times a day.
  • 6-12 years - 1 teaspoon up to 3 times a day.

The dosage regimen for adults and children over 12 years of age is 1 teaspoon of Lazolvan syrup for adults (30 mg/5 ml) three times a day. It is recommended to take this form of the drug during meals with water. The duration of treatment is no more than 5 days.

Lazolvan for inhalation

Lazolvan inhalation solution enhances the outflow and transport of mucus and helps relieve cough. During the treatment of patients with a history of chronic obstructive pulmonary disease, long-term use of Lazolvan significantly reduces the number of exacerbations. The instructions for Lazolvan for inhalation indicate that the drug can be used not only for inhalation, but also for oral administration.

The solution contains benzalkonium chloride, which can provoke the development of bronchospasms in patients with increased reactivity of the respiratory system.

Parents need to check with their doctor about how to dilute Lazolvan for inhalation for children. As a rule, a child under 6 years of age is recommended to take 1-2 inhalations with 2 ml of the drug per day.

When carrying out inhalation with Lazolvan and saline solution, the dosage for adults is 2-3 ml of the medicine up to 3 times a day. More details on how to carry out this procedure will be discussed below.

Lazolvan solution should not be mixed with alkaline solutions and products based on cromoglycic acid. Combination with antitussive drugs that make it difficult to remove sputum is also undesirable.

The instructions for use of Lazolvan for inhalation give the following recommendations regarding dosage for internal administration of the drug:

  • For children under 2 years old, give 1 ml of the product twice a day.
  • Children from 2 to 6 years old - 1 ml three times a day.
  • Children 6-12 years old - 2 ml three times a day.
  • The dosage of Lazolvan for inhalation for children over 12 years of age and adults is 4 ml three times a day.

For oral administration, the drug should be diluted in liquid: water, milk, juice, tea.

Inhalations with saline solution

A pure solution of the drug is not suitable for inhalation. It is important to know how to dilute Lazolvan for inhalation with saline solution. As a rule, they are mixed in a 1:1 ratio. This concentration of active components helps accelerate the process of liquefaction and removal of sputum.

The use of a solution for inhalation helps to increase the penetration of antibacterial substances into the bronchial mucus: amoxicillin, erythromycin, cefuroxime.

A table on inhalations with Lazolvan and saline solution, indicating the proportion, frequency and duration of the procedures, will help you not to make a mistake.

Inhalations of Lazolvan and saline solution should not be carried out using steam inhalers. If after 4-5 days there is no expected therapeutic effect, a second consultation with the attending physician is required.

How to do inhalations correctly

It is important to know how to inhale with Lazolvan. To carry out the procedure, it is necessary to use any modern equipment designed for inhalation, for example, nebulizers - devices that help spray medications in the form of tiny particles.

Before using the inhaler, you should assemble it correctly and study the instructions for use, care and storage.

During the procedure, you must adhere to the following recommendations:

  • During inhalation, the patient is recommended to be in a sitting position. Carrying out inhalations in a supine position is possible only with the use of mesh nebulizers.
  • Inhalations should be carried out 90 minutes after meals or physical activity.
  • The aerosol is inhaled through the mouth through a specially designed nozzle: this allows you to accelerate the achievement of therapeutic effects. After inhaling, it is recommended to hold your breath for a few seconds and exhale through your nose.
  • During the procedure, inhaling too deeply can provoke a severe coughing attack, so you need to breathe evenly during inhalation.
  • When treating bronchial asthma, inhalation should be carried out after using medications with bronchodilator action. This helps prevent spasm and irritation of the airways.
  • The recommended temperature of the finished mixture should be approximately equal to human body temperature. This helps prevent the development of irritation in the respiratory tract.
  • Children wear a special mask during inhalation; adults use a mouthpiece that prevents the accumulation of medicine in the nasal cavity. The mask must first be wiped with hydrogen peroxide or a special disinfectant. You can't boil it.
  • The procedure should not be performed before bedtime, since the drug stimulates the secretion and removal of mucus, which can cause a severe cough.
  • You cannot use steam inhalers when performing inhalations with Lazolvan solution.

Patients with pulmonary hemorrhage, arrhythmia and severe dysfunction of the cardiovascular system should refrain from inhalation.

Side effects

Cough inhalation with Lazolvan can most often provoke the development of the following undesirable side reactions:

  • Nausea, loss of sensitivity in the oral cavity.
  • Allergic reactions.
  • Impaired sense of taste.

It is also possible to develop dyspeptic disorders, vomiting, stool disorders, abdominal pain, dry mouth and throat, skin rash, hives, swelling, itching.

Adverse reactions are mild, transient, and in most cases do not require discontinuation of use of the medication.

In case of overdose, nausea, dyspeptic disorders, abdominal pain, and bowel disorders may develop. In this case, it is necessary to induce artificial vomiting, rinse the stomach and consult a doctor for symptomatic treatment.

Analogue of the drug

A frequently prescribed analogue of Lazolvan for inhalation is Ambrobene.

This is a mucolytic agent that simultaneously has a secretomotor, secretolytic and expectorant effect. The active ingredient is ambroxol hydrochloride. The solution for inhalation is available in dark glass bottles of 40 and 100 mg.

Ambrobene is prescribed for pneumonia, bronchitis, obstructive pulmonary disease, in particular for bronchial asthma. It can even be used to treat newborns.

The question often arises, which is better for inhalations: Lazolvan or Ambrobene? The choice of drug is left to the doctor and the patient. It should be remembered that these drugs are analogues, the quantitative content of the active component in them is identical.

Inhalations with Lazolvan for dry cough may not provide the desired therapeutic result. In this case, drugs should be used that reduce the viscosity of mucus and eliminate the inflammatory process (Berotek, Berodual, Salgima). The selection of medicine is carried out taking into account the root cause that provoked the cough.

Source: http://moylor.ru/lekarstva/rastvor-lazolvan-dlya-ingalyacij-pravila-primeneniya/

Lazolvan

Lazolvan: instructions for use and reviews

Latin name: Lasolvan

ATX code: R05CB06

Active ingredient: ambroxol (ambroxol)

Manufacturer: Instituto De Angeli (Italy), Boehringer Ingelheim Ellas (Greece), Bolder Arzneimittel GmbH & Co. KG (Germany), Delpharm Reims (France)

Update of description and photo: 08/29/2017

Prices in pharmacies: from 156 rubles.

Lazolvan is an expectorant and mucolytic drug.

Release form and composition

Lazolvan is produced in the following dosage forms:

  • Lozenges: round, light brown, with the smell of peppermint (in blisters of 10 pcs., 1, 2 or 4 blisters in a cardboard box);
  • Tablets: round, slightly yellowish or white, flat on both sides, with beveled edges, on one side there is a separating line and the inscription “67C” embossed on both sides of it, on the other - the company symbol (in blisters of 10 pcs., 2 or 5 blisters in a cardboard box);
  • Syrup: almost colorless or colorless, almost transparent or transparent, with the smell of wild berries (15 mg/5 ml each) or strawberry smell (30 mg/5 ml each), slightly viscous (in dark glass bottles of 100, 200 or 250 ml per complete with or without a measuring cup, 1 bottle in a cardboard box);
  • Solution for oral administration and inhalation: transparent, slightly brownish or colorless (in dark glass bottles of 100 ml, complete with a dosing cup or beaker, 1 bottle in a cardboard box).

The composition of 1 lozenge Lazolvan includes:

  • Active substance: ambroxol – 15 mg (in the form of hydrochloride);
  • Auxiliary components: acacia gum – 850 mg, sorbitol – 307.4 mg, carion 83 (mannitol, sorbitol, hydrogenated hydrolyzed starch) – 614.8 mg, peppermint leaf oil – 10 mg, eucalyptus leaf oil – 2 mg, saccharin sodium – 1.8 mg, liquid paraffin (purified mixture of liquid saturated hydrocarbons) – 2.4 mg, purified water – 196.6 mg.

The composition of 1 tablet Lazolvan includes:

  • Active substance: ambroxol – 30 mg (in the form of hydrochloride);
  • Auxiliary components: lactose monohydrate – 171 mg, dried corn starch – 36 mg, colloidal silicon dioxide – 1.8 mg, magnesium stearate – 1.2 mg.

The composition of 5 ml of Lazolvan syrup includes:

  • Active substance: ambroxol – 15 or 30 mg (in the form of hydrochloride);
  • Auxiliary components (15/30 mg per 5 ml, respectively): benzoic acid - 8.5/8.5 mg, hydroxyethylcellulose (hyetellose) - 10/10 mg, acesulfame potassium - 5/5 mg, liquid sorbitol (non-crystallizing) - 1750/1750 mg, glycerol 85% – 750/750 mg, vanilla flavor – 3/3 mg, purified water – 3047.5/3031.5 mg, wild berry flavor PHL – 11 mg (for syrup 15 mg/5 ml) or strawberry-cream flavor PHL – 12 mg (for syrup 30 mg/5 ml).

The composition of 1 ml of solution for oral administration and inhalation of Lazolvan includes:

  • Active substance: ambroxol – 7.5 mg (in the form of hydrochloride);
  • Auxiliary components: citric acid monohydrate - 2 mg, sodium hydrogen phosphate dihydrate - 4.35 mg, sodium chloride - 6.22 mg, benzalkonium chloride - 0.225 mg, purified water - 989.705 mg.

Pharmacological properties

Pharmacodynamics

Research data show that ambroxol, which is the active component of Lazolvan, causes an increase in secretion in the respiratory tract. As a result of exposure to the drug, the production of pulmonary surfactant and ciliary activity are enhanced. These effects stimulate the flow and transport of mucus (mucociliary clearance), resulting in intense mucus discharge and cough relief. In the treatment of chronic obstructive pulmonary disease during long-term therapy with Lazolvan (for 2 months or more), the number of exacerbations decreased significantly. A significant decrease in the duration of exacerbations and the number of days of antibiotic therapy was recorded.

Pharmacokinetics

All dosage forms of immediate release ambroxol are characterized by rapid and almost complete absorption (a linear dependence of absorption on dose is observed). When taken orally, the maximum concentration of ambroxol in plasma is achieved after 60–150 minutes. Distribution volume – 552 l. The binding of ambroxol to plasma proteins in the therapeutic concentration range is approximately 90%.

When administered orally, the transition of the active substance from the blood to the tissues occurs quickly. The highest concentrations of ambroxol are observed in the lungs. About 30% of an oral dose undergoes a first pass process through the liver. Studies on human liver microsomes have proven that the predominant isoform is the CYP3A4 isoenzyme. It is responsible for the metabolism of the active substance to dibromanthranilic acid. The remaining amount is metabolized in the liver, mostly by glucuronidation and through partial degradation (approximately 10%) to dibromoantranilic acid and additional metabolites in small quantities. The terminal half-life is 10 hours. Total clearance is up to 660 ml/min, with about 8% of the total clearance being renal clearance. In studies using the radioactive tracer method, it was calculated that as a result of taking a single dose of ambroxol over the next 5 days, approximately 83% of the dose taken is excreted in the urine.

A clinically significant effect of gender and age on the pharmacokinetics of ambroxol has not been recorded, so there is no reason to select the dosage based on these characteristics.

Indications for use

Lazolvan is prescribed for the treatment of the following acute and chronic diseases of the respiratory tract, which occur with the release of viscous sputum:

  • Bronchiectasis;
  • Pneumonia;
  • Bronchitis in acute and chronic course;
  • Bronchial asthma, occurring with difficulty in sputum discharge;
  • Chronic obstructive pulmonary disease.

Contraindications

  • First trimester of pregnancy and lactation period;
  • Hypersensitivity to the components of the drug.

Lazolvan should be used with caution in pregnant women in the second and third trimesters, as well as in those with renal and/or liver failure.

Children, depending on the dosage form of Lazolvan, can take:

  • Lozenges and syrup 30 mg/5 ml: from 6 years;
  • Tablets: from 18 years of age.

The lozenges, based on the maximum recommended daily dose (90 mg), contain 3200 mg of sorbitol, so patients with rare hereditary fructose intolerance should not take Lazolvan in this dosage form.

Lazolvan in tablet form is contraindicated for patients with lactase deficiency, lactose intolerance and glucose-galactose malabsorption.

Lazolvan syrup should not be taken by patients with hereditary fructose intolerance.

Instructions for use of Lazolvan: method and dosage

Lazolvan is used orally or inhaled.

The drug can be taken orally regardless of the time of meal.

Lozenges should be slowly dissolved in the mouth, tablets should be taken with liquid, the solution can be diluted in juice, tea, milk or water.

As a rule, Lazolvan is prescribed orally:

  • Lozenges: adults and children over 12 years old – 3 times a day, 2 lozenges; children 6-12 years old – 2-3 times a day, 1 lozenge;
  • Tablets: 3 times a day, 1 tablet; to enhance the therapeutic effect, it is possible to increase the daily dose (2 times a day, 2 tablets);
  • Syrup 15 mg/5 ml: adults and children over 12 years old – 3 times a day, 10 ml; children 6-12 years old – 2-3 times a day, 5 ml; children 2-6 years old – 3 times a day, 2.5 ml; children under 2 years old – 2.5 ml 2 times a day;
  • Syrup 30 mg/5 ml: adults and children over 12 years old – 3 times a day, 5 ml; children 6-12 years old – 2-3 times a day, 2.5 ml;
  • Oral solution (1 ml = 25 drops): adults and children over 12 years old – 3 times a day, 100 drops; children 6-12 years old – 2-3 times a day, 50 drops; children 2-6 years old – 3 times a day, 25 drops; children under 2 years old – 2 times a day, 25 drops.

Inhalation Lazolvan is usually prescribed:

  • Adults and children over 6 years old – 1-2 inhalations of 2-3 ml of solution per day;
  • Children under 6 years old – 1-2 inhalations of 2 ml of solution per day.

For inhalation, you can use any modern equipment designed for this (except for steam inhalers). To ensure optimal hydration during inhalation, Lazolvan should be mixed with a 0.9% sodium chloride solution in a 1:1 ratio. Since during inhalation therapy a deep breath can lead to the development of a cough, inhalations must be carried out while maintaining a normal breathing rhythm. Before the procedure, it is recommended to warm the Lazolvan inhalation solution to body temperature. Patients with bronchial asthma are recommended to carry out inhalation after taking bronchodilator drugs, which will help avoid nonspecific irritation of the respiratory tract and their spasm.

If symptoms of the disease persist for 4-5 days from the start of taking Lazolvan, it is recommended to consult a doctor.

Side effects

As a rule, Lazolvan is well tolerated.

The following side effects may develop during therapy:

  • Gastrointestinal tract: often - nausea, decreased sensitivity in the esophagus or mouth; uncommon – diarrhea, dyspepsia, heartburn, vomiting, pain in the upper abdomen, dry mucous membrane of the throat and mouth;
  • Nervous system: often – disturbance of taste sensations;
  • Immune system, skin and subcutaneous tissues: rarely - urticaria, rash, angioedema, anaphylactic reactions (including anaphylactic shock), itching and other allergic reactions.

Overdose

Specific symptoms of Lazolvan overdose in humans have not been described.

There is evidence of a medical error and/or accidental overdose, as a result of which symptoms of side effects known for this drug were recorded: dyspepsia, nausea, vomiting, diarrhea, abdominal pain. In some cases, there is a need for symptomatic therapy.

Treatment: you should artificially induce vomiting, rinse the stomach for 1-2 hours after taking the drug. Symptomatic therapy is also indicated.

special instructions

Lazolvan should not be combined with antitussive drugs that impede the removal of sputum.

In patients with severe skin lesions (toxic epidermal necrolysis or Stevens-Johnson syndrome), the early phase may include fever, rhinitis, body pain, sore throat and cough. During symptomatic therapy, it is possible to erroneously prescribe mucolytic drugs such as Lazolvan. There are isolated reports of the detection of toxic epidermal necrolysis and Stevens-Johnson syndrome, which coincided with its administration, but there is no cause-and-effect relationship with the use of Lazolvan.

If the above syndromes develop, you should stop using the drug and immediately seek help from a doctor.

In case of functional disorders of the kidneys, Lazolvan can be used only as prescribed by a doctor.

1 tablet contains 162.5 mg of lactose, in the maximum daily dose (4 tablets) – 650 mg of lactose.

The sorbitol contained in the syrup may have a slight laxative effect. The maximum recommended daily dose of syrup contains 5 g (in 20 ml of syrup 30 mg/5 ml) or 10.5 g (in 30 ml of syrup 15 mg/5 ml) of sorbitol.

The solution for oral administration and inhalation contains the preservative benzalkonium chloride, which during inhalation can cause bronchospasm in patients with increased respiratory tract reactivity. The solution is not recommended to be mixed with alkaline solutions and cromoglycic acid. An increase in the pH value of the solution above 6.3 may lead to precipitation of the active substance or the appearance of opalescence.

Patients who follow a low-sodium diet should take into account that the recommended daily dose (for adults and children over 12 years of age) of Lazolvan in the form of a solution for oral administration and inhalation contains 42.8 mg of sodium.

Use during pregnancy and lactation

Ambroxol penetrates the placental barrier. Preclinical studies did not reveal any direct or indirect adverse effects of the drug on the course of pregnancy, embryonic/fetal, postnatal development and labor.

Extensive clinical experience with the use of the drug from the 28th week of pregnancy has shown no evidence of a negative effect of the drug on the fetus, however, when using Lazolvan during pregnancy, the usual precautions should be followed. The drug is not recommended to be taken in the first trimester of pregnancy. Use in the second or third trimesters is allowed only in cases where the possible risk to the fetus is lower than the potential benefit to the mother.

Ambroxol is excreted in breast milk. There is no data on the development of undesirable effects in children who were breastfed, however, it is not recommended to use Lazolvan during lactation.

Preclinical studies of ambroxol did not reveal any negative effects on fertility.

Use in childhood

When treating children under 12 months of age, Lazolvan is used only in the form of a solution. In such cases, it is necessary to ensure constant medical supervision.

According to the instructions, Lazolvan in the form of tablets is prohibited for use in the treatment of children under the age of 18 years, in the form of lozenges - up to 6 years.

For impaired renal function

In case of renal failure, the drug should be used with caution.

For liver dysfunction

In case of liver failure, the drug should be used with caution.

Drug interactions

There are no data on undesirable clinically significant interactions of Lazolvan with other drugs.

Lazolvan increases the penetration of drugs such as cefuroxime, amoxicillin and erythromycin into the bronchial secretions.

Analogs

Analogs of Lazolvan are: Ambroxol, Ambroxol Vramed, Ambrobene, Medox, Ambrohexal, Bronchorus, Halixol, Flavamed, Lazolvan Uno.

Terms and conditions of storage

Store in a place protected from light, out of reach of children.

  • Lozenges – 3 years at temperatures up to 30 °C;
  • Tablets – 5 years at temperatures up to 30 °C;
  • Syrup – 3 years at temperatures up to 25 °C;
  • Solution for oral administration and inhalation – 5 years at temperatures up to 25 °C.

Conditions for dispensing from pharmacies

Available without a prescription.

Reviews about Lazolvan

Reviews about Lazolvan are mostly positive. Users note that within a few days after taking the drug, there is an improvement in bronchitis and other diseases. According to reviews from parents, Lazolvan in the form of an inhalation solution and syrup has proven itself well in the treatment of children.

Also, some users report the development of side effects (diarrhea, allergic skin reactions).

Price for Lazolvan in pharmacies

The approximate price for Lazolvan is:

  • lozenges (20 pcs per pack) – 211 rubles;
  • tablets: 50 pcs. – 290 rub., 20 pcs. – 170 rub.;
  • syrup in 100 ml bottles: 15 mg/5 ml – 215 rubles, 30 mg/5 ml – 280 rubles;
  • solution for oral administration and inhalation 7.5 mg/ml in 100 ml bottles – 380 rub.

Lazolvan tablets 30 mg 20 pcs.

Lazolvan tab. 30mg n20

Lazolvan 15 mg No. 20 lozenges

Lazolvan 30 mg No. 20 tablets

Lazolvan tablets 30 mg n20

Lazolvan Max capsules 75 mg 10 pcs.

Lazolvan syrup 15 mg/5 ml 100 ml

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Source: http://www.neboleem.net/lazolvan.php

Life without a cough

But here’s what’s interesting: for some, the manifestations of the disease are limited only to periodic coughing, while others suffer from a severe, debilitating cough for several weeks. What needs to be done so that, if you are unlucky enough to catch a cold, then you end up in the first group?

It would seem that the answer is obvious - you need to start taking effective medicine in a timely manner. However, today in any pharmacy an entire display case is devoted to a variety of cough remedies. With such a variety of drugs, the correct choice of medicine depends not only on the severity of the disease accompanied by a cough and the speed of recovery, but also on the possibility of preventing its transition to a more dangerous form.

Cough - what is it?

Most often, both a mild cough and a severe suffocating cough are part of the same mechanism, in which irritation of the receptors causes a sharp contraction of the muscles of the respiratory tract. This phenomenon is protective in nature - thanks to it, accumulating mucus is expelled from the respiratory tract, and the risk of inflammation of the upper respiratory tract turning into severe bronchitis or even pneumonia is reduced.

But the body’s sanitizing reaction, its kind of “wet cleaning,” is only the so-called productive cough, in which sputum is quite easily and completely evacuated from the respiratory tract.

However, this process, which is necessary for the body, is often significantly hampered due to a whole range of circumstances. Firstly, during inflammatory processes in the respiratory tract, the formation of bronchial secretions increases significantly. Secondly, its composition changes significantly (the concentration of mucins increases), which leads to an increase in the viscosity of sputum. Thirdly, the activity of the cilia of the ciliated epithelium, which promote sputum “towards the exit”, noticeably decreases. And finally, inflammation causes swelling of the mucous membrane lining the respiratory tract, which leads to impaired bronchial obstruction. As a result of all this, conditions are created for the accumulation and stagnation of sputum, which, in turn, becomes favorable soil for the proliferation of pathogenic microorganisms in the respiratory tract.

It is necessary to mention one more negative circumstance: under conditions of stagnation of sputum in the bronchial secretion, the content of the main factors of local immunity, which have antiviral and antimicrobial activity, decreases. Consequently, local immune defense is suppressed.

It turns out that in such a situation, the insufficiency of sputum evacuation mechanisms should be compensated by increased coughing. However, this is hampered by the increased viscosity of sputum, the removal of which now requires very significant efforts, which results in a prolonged, severe cough with a small amount of sputum.

It is worth noting that after coughing up sputum, the patient’s condition immediately noticeably improves - the whole problem lies precisely in the difficulty of this process. Therefore, it is obvious that in such a situation it is necessary to help the body cope with the disease and its consequences as quickly as possible. This requires pharmaceutical support with a drug that would be able to facilitate the evacuation of sputum.

First - clean

Modern complex treatment of patients with respiratory diseases accompanied by an unproductive cough, along with drinking a sufficient amount of fluid, necessarily includes the use of drugs that help reduce the viscosity of sputum.

Today, to improve the “drainage” function of the bronchial tract and facilitate the removal of sputum physiologically, mucolytic agents are widely used, among which it is worth highlighting Lazolvan, produced by the German pharmaceutical company Boehringer Ingelheim.

This mucolytic drug has a pronounced expectorant effect. In addition, it successfully stops inflammatory processes in the tissues of the respiratory system, and also exhibits antioxidant properties.

Fourth decade of success

Developed by Boehringer Ingelheim, ambroxol hydrochloride was first registered in Germany in August 1978. Since then, various forms of this drug have been registered in more than 100 countries around the world; all of them are successfully used to treat diseases of the respiratory tract, accompanied by changes in sputum secretion and difficulty in its evacuation.

Lazolvan® provides a complex therapeutic effect, influencing several links in the pathogenetic mechanism of development of unproductive cough.

Firstly, under the influence of the active substance of Lazolvan, ambroxol, the amount of sputum significantly increases and its consistency changes (the ratio of serous and mucous components is normalized), due to which it becomes less viscous and much easier to cough up.

Secondly, ambroxol stimulates the motor activity of the cilia of the ciliated epithelium of the bronchi and prevents their adhesion, which also contributes to the timely evacuation of sputum from the respiratory tract.

And thirdly, ambroxol increases the formation of a special surfactant in the pulmonary alveoli - the so-called surfactant, which lines their inner surface with a thin film and protects them from the effects of adverse factors. Surfactant improves the “sliding” of bronchopulmonary secretions along the epithelium and thereby facilitates the evacuation of sputum from the respiratory tract.

Protect and cure

The drug also has a slight antitussive effect - this is of great importance in the treatment of a number of diseases when it is undesirable to stimulate the cough reflex.

Lazolvan has another important property - it helps to increase the production of immunoglobulins and activate local immunity in the lungs and bronchi.

In addition, Lazolvan has an anti-edematous effect, which is of particular importance in the treatment of inflammatory lung diseases.

And finally, it is worth especially noting that Lazolvan enhances the effect of antibiotics - after all, as is known, the success of antibacterial therapy depends not only on the sensitivity of microorganisms, but also on the concentration of the drug in the lesion. And ambroxol helps to increase the concentration of antibiotics in the respiratory organs.

Cough syrup is a tradition!

The most popular form of cough medication is syrup. Lazolvan is produced in two versions: Children's syrup 15 mg ambroxol (this syrup has a raspberry flavor). Another, orange and apricot flavored, contains 30 mg of ambroxol. Children's syrup is usually used for young children, and the second is perfect for treating both adults and children over 6 years of age.

Lazolvan® syrup is very widely used in pediatric practice, being one of the most effective and safe drugs. Indeed, the syrup is especially convenient for treating children, since it tastes very pleasant and contains neither sugar nor alcohol.

It must be said that in addition to syrup, Lazolvan is available in several dosage forms, which is also very convenient, since it allows the buyer to choose either a more familiar form or one that is more suitable for a given situation.

Lazolvan tablets are used for patients over 6 years of age. There is also a solution of Lazolvan for internal use - it can be taken as a medicine, and also inhaled with it.

Thanks to this, you can always choose the most suitable release form for any patient. Perhaps this is why Lazolvan® is deservedly called a drug for the whole family.

Any questions?

It is not surprising that with regard to such a popular drug as Lazolvan, buyers usually have many questions. We will answer the ones that are asked most often.

How long will it take for the medicine to start working?

One of the important advantages of Lazolvan is that when using it, you do not need to wait for the onset of the therapeutic effect for several days. Already 30 minutes after administration, a high concentration of the drug in the blood plasma is observed (which is important, the main part of the drug accumulates in the bronchi and lungs). Thanks to this, the therapeutic effect of Lazolvan occurs very quickly (half an hour after taking the medicine, the condition noticeably improves) and lasts from 6 to 12 hours (this depends, in particular, on what dose of the drug was taken).

How much Lazolvan syrup should a child be given?

For a child from 1 to 2 years old, the possible dosage of Lazolvan is half a teaspoon twice a day. It is recommended to give half a teaspoon 3 times a day to children from 2 to 6 years old. Children from 6 to 12 years old – one teaspoon of Lazolvan 2-3 times a day. And finally, children over 12 years old can be given 2 teaspoons of Lazolvan 3 times a day

Can Lazolvan be taken together with other drugs?

Lazolvan combines well with other medications. It can be taken with any medications, except, of course, antitussives. And the effect of antibiotics, as we have already said, is enhanced by combination with Lazolvan, since it helps to increase their concentration in the respiratory organs.

How safe is this drug?

Lazolvan has a very good safety profile - this is evidenced by the possibility of its use after the 28th week of pregnancy and in small children.

Unlike some mucolytic drugs, Lazolvan does not provoke the development of bronchospasm - this allows its inhaled forms to be widely used in patients with airway hyperresponsiveness (primarily with bronchial asthma).

Is it possible to take Lazolvan for a long time?

This is completely safe, since Lazolvan® is completely eliminated from the body and does not accumulate in it even with prolonged use. That is why experts usually recommend it for the treatment of long-term or chronic diseases.

The drug has contraindications and side effects. Consult your physician before use.

The article was published in the journal Pharmacy Business, No. 9 September 2011.

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Any use of materials is permitted only with the written consent of the editors.

Source: http://doktor.ru/txt/g55lx6/

Lazolvan for cough: rules of administration, is it possible for pregnant women and children

Lazolvan for cough is effective if the patient has thick sputum accumulated in the respiratory tract, which does not separate on its own. To improve the patency of the bronchi and trachea, the use of mucolytic agents is indicated. They liquefy mucus, after which it can be easily released due to the cough reflex.

Composition and beneficial properties of Lazolvan for cough

The active ingredient of the drug is Ambroxol. This is a strong mucolytic agent, which not only reduces the viscosity of sputum, but also helps to increase the production of mucus in the walls of the respiratory tract. Taking Lazolvan can significantly shorten the recovery time and help get rid of cough even in advanced cases.

The effectiveness of the drug depends on how early it was started. It is best to start treatment in the early stages of the disease, when the body’s defenses are still strong enough to cope with the disease with minimal drug support.

Increased mucus production not only helps to cleanse the respiratory tract, but also helps remove pathogenic microbes and toxic products of their vital activity from the body. For bronchitis and other diseases of the respiratory tract, Lazolvan has the following effect:

  • normalizes the composition and viscosity of sputum due to the action of enzymes;
  • enhances the secretion of mucus to increase the fluidity of the discharge;
  • due to the increase in the amount of liquid sputum, it makes it easier to cough up accumulated mucus;
  • increases the concentration of antibacterial agents in the respiratory tract;
  • stimulates the production of antibodies and enhances local protective factors in the lungs and bronchi.

Thanks to this effect, Lazolvan is widely used both for the treatment of bronchitis and in the treatment of pneumonia. It copes well with severe cough syndrome, helps with wet coughs, and also helps reduce the negative effects of antibiotics. The latter is achieved due to the fact that the patient has to take a smaller amount of antibacterial agents in order to achieve the required concentration in the lungs and bronchi.

Important! Treatment of inflammatory diseases of the respiratory system should be comprehensive. Mucolytics are only auxiliary agents that help speed up recovery, but their action is not aimed at the cause of the disease. Therefore, you should always use additional antibiotics or antiviral drugs.

For what type of cough is it used?

Lazolvan is indicated to be taken in the form of tablets or syrup, as well as administered intramuscularly and intravenously for various diseases of the respiratory system that are associated with the formation of thick sputum. Therefore, it is advisable to use it to treat dry cough. But the use of the medicine is also allowed in cases where sputum is produced, but it is quite difficult to pass away.

It is recommended to use Lazolvan for the following acute and chronic pathologies:

  • bronchitis;
  • pneumonia;
  • chronic pathologies of lung tissue;
  • bronchial asthma;
  • bronchiectasis.

Another use of Lazolvan is not related to cough. It is used to accelerate lung maturation in prematurely born children. If a baby is born with signs of postpartum distress syndrome, medication is administered intramuscularly or intravenously. This is necessary so that the walls of the respiratory tract begin to produce all the substances necessary for breathing.

How to use correctly

Lazolvan in tablet form can be taken by patients over 12 years of age. On the first day of treatment, it is recommended to take one tablet after meals three times a day. In subsequent days, the dosage is reduced to twice taking one tablet or three times taking half.

In the presence of severe cough syndrome, it is allowed to give the medicine to children over six years of age. Such patients can take half a tablet no more than three times a day. Lazolvan syrup can also be used from the age of six. The recommended dosage is half a teaspoon three times a day.

People over 12 years of age should drink one tablespoon of syrup three times a day during the first three days of treatment. After this, the dosage is reduced to one teaspoon. If therapy is not effective enough in the first three days, you can leave the same amount of medication.

A single dosage of Lazolvan in the form of a solution for adults is 15 ml. In severe cases, the amount of medicine should be doubled. The drug is administered subcutaneously, intramuscularly or intravenously, depending on the severity of symptoms and the severity of the patient’s condition. The frequency of administration is three times a day.

For children, the maximum daily dose for the parenteral form of Lazolvan is calculated based on body weight - 1.5 mg of active substance per kilogram of the child’s weight. Usually the medicine is used according to the following scheme:

  • children under two years old – half an ampoule (7.5 mg) twice a day;
  • up to five years - the same amount of the drug three times a day;
  • over five years old - 15 mg three times a day.

Important! With the development of postpartum respiratory distress syndrome, intramuscular administration of Lazolvan in the amount of 10 mg per kilogram of weight is indicated. The drug is administered up to four times a day. If the serious condition of the newborn persists, the recommended dose may be exceeded.

Use of Lazolvan in children

For the treatment of dry or wet cough in children, the most suitable form of medication is syrup. Since it has a pleasant taste, children take it well in the recommended amount. Lazolvan does not contribute to the development of severe adverse reactions and is at the same time quite effective in clearing the respiratory tract. It is recommended to be given to children over six years of age.

Lazolvan for dry cough helps reduce the viscosity of sputum and improves its discharge. Therefore, after taking it, the severity of the symptom may increase, but this does not indicate a deterioration in the patient’s condition. Increasing cough indicates that the mucus that was previously in the lower respiratory tract is beginning to be coughed up. This helps to achieve a speedy recovery and improve the baby’s well-being.

The drug solution can be used for inhalation. Before this, it must be diluted in water. This method of using the medicine is allowed for children of any age, even infants. If the child has significantly severe symptoms, intramuscular or intravenous administration of Lazolvan is indicated.

Important! Before starting treatment, it is recommended to consult a pediatrician. This is necessary so that the doctor can assess the severity of the patient’s condition and select an individual dose of the medicine. Self-medication is prohibited, since improper use of the drug can lead to a deterioration in health, increased severity of symptoms, and the development of unwanted reactions.

Use of Lazolvan during pregnancy and breastfeeding

Pregnant patients who have no sputum can take Lazolvan cough syrup in the second or third trimester. It is not recommended to start treatment on your own; it is better to carry out therapy under the supervision of your doctor. This is due to the fact that uncontrolled use of the drug can lead to the development of undesirable reactions, including those leading to damage to the fetus.

In the first trimester of pregnancy, the most intensive development of the child's organs occurs. The effect of Lazolvan on the fetus during this period has not been fully studied. Therefore, taking it in any form before the third trimester is prohibited.

Breastfeeding women are advised to use Lazolvan with caution. This is due to the fact that the medicine easily passes into breast milk and can affect the baby's body. The drug in syrup form is considered the safest.

Is the product safe?

If you take the medicine according to indications and only to those patients who are authorized to use the drug, then the likelihood of developing side effects will be minimal. Adverse reactions are most often associated with allergies and individual intolerance to the active ingredient and excipients.

They can manifest as redness, itching of the skin, and indigestion. If any unpleasant symptoms occur after taking it, you should stop using the medicine and report the complication to your doctor.

Knowing what kind of cough Lazolvan is used for, you can effectively use it to get rid of the symptom. It is better to carry out treatment under the supervision of a specialist - this way you can avoid the occurrence of unwanted reactions and achieve a speedy recovery.

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You should not start treatment without first consulting with a doctor or specialist.

Source: http://med-gorlo.ru/preparaty-i-lekarstva/lazolvan-ot-kashlya.html