Bioparox instructions composition

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BIOPAROX

◊ Aerosol for inhalation, dosed in the form of a yellow solution with a specific odor.

Excipients: aromatic additive 80 mg, anhydrous ethanol mg, saccharin - 1.25 mg, isopropyl myristate - 85.32 mg, propellant 1,1,1,2-tetrafluoroethane (HFA 134a) mg.

Table of contents:

10 ml (400 inhalations) - aluminum aerosol cans with a dosing valve (1) complete with spray nozzles and activator cap - contour cell packaging (1) with a case for portable carrying - cardboard packs.

Antibiotic for local use. Has antibacterial and anti-inflammatory activity.

In vitro, Bioparox is active against: Streptococcus spp. group A, Streptococcus pneumoniae (old name - Pneumococcus), Staphylococcus spp., some strains of Neisseria spp., some anaerobes, as well as Mycoplasma spp., fungi of the genus Candida. Fusafungin is believed to have similar activity in vivo.

Fusafungin has a pronounced anti-inflammatory effect by reducing the concentration of tumor necrosis factor (TNFα) and suppressing the synthesis of free radicals by macrophages while maintaining phagocytosis.

After inhalation use of the drug Bioparox, fusafungin is mainly distributed on the surface of the mucous membrane of the oropharynx and nasal cavity. Fusafungin can be detected in blood plasma in very low concentrations (no more than 1 ng/ml), which does not affect the safety of the drug.

- treatment of infectious and inflammatory diseases of the respiratory tract (rhinitis, nasopharyngitis, pharyngitis, laryngitis, tracheitis, tonsillitis, conditions after tonsillectomy, sinusitis).

- children under 2.5 years of age (risk of developing laryngospasm);

- hypersensitivity to the active substance or to the excipients included in the drug.

with caution in patients prone to allergic reactions and bronchospasm.

The drug is used in the form of inhalation (through the mouth and/or nose).

Adults are prescribed 4 inhalations through the mouth and/or 2 inhalations into each nasal passage 4 times a day.

Children over 2.5 years old are prescribed 2-4 inhalations through the mouth and/or 1-2 inhalations into each nasal passage 4 times a day.

To make maximum use of the activity of the Bioparox drug, it is necessary to follow the prescribed doses and follow the rules for using the attached attachments.

To obtain a lasting therapeutic effect, it is necessary to observe the duration of the prescribed treatment: it is not recommended to stop treatment when the first signs of improvement appear, because premature cessation of therapy may lead to relapse.

You should always have the drug with you, placing it in the attached portable carrying case.

The duration of treatment, as a rule, does not exceed 7 days.

After completing the 7-day course of treatment, the patient should consult a doctor to assess the effectiveness of therapy.

If symptoms of the disease and/or elevated temperature persist during therapy with Bioparox, the patient should inform the attending physician.

In the case of pronounced clinical manifestations of a bacterial infection, treatment with Bioparox in combination with systemic antibiotics is possible.

Rules for using the drug

Before using the canister for the first time, press its base 4 times to activate it.

Inhalations through the nose should be carried out for rhinitis, nasopharyngitis, and sinusitis . Before inhalation, you should clean your nose. The container with the drug must be held vertically with the nozzle upward, holding it between the thumb and forefinger. To carry out inhalation through the nose, attach the nozzle to the balloon (yellow for adults or transparent for children) and insert it into the nasal passage (while holding the opposite nasal passage and closing the mouth). While inhaling deeply through your nose, press the base of the balloon vigorously and all the way.

Oral inhalation . Place the white nozzle on the balloon, insert it into your mouth, pressing it tightly with your lips, while holding the balloon vertically and slightly tilted.

For pharyngitis, tonsillitis, conditions after tonsillectomy, laryngitis, you should press firmly and for a long time on the bottom of the balloon and take a deep breath to completely irrigate the tonsils and pharynx.

For tracheitis , before inhalation it is necessary to cough, then deeply inhale the aerosol mixture and hold your breath for a few seconds to completely irrigate the trachea.

The attachments should be disinfected every other day using a cotton swab soaked in ethanol (90%).

The following side effects were observed while taking fusafungin with the following frequency: very often (≥1/10), often (≥1/100, <1/10), infrequently (≥1/1000, <1/100), rarely ( ≥1/10,000, <1/1000), very rare (<1/10,000) and unknown frequency (frequency cannot be calculated from available data).

Allergic reactions are very rare. It is possible to develop local, quickly passing reactions, mainly in patients predisposed to allergies.

General disorders and symptoms: very often - sneezing, unpleasant taste in the mouth, redness of the mucous membrane of the eyes; often - dry mucous membranes of the respiratory tract, irritation in the throat, cough, nausea; unknown frequency - vomiting. There is usually no need to stop treatment.

From the immune system: very rarely - anaphylactic shock.

From the respiratory system: very rarely - asthmatic attacks, attacks of bronchial asthma, shortness of breath, laryngospasm, Quincke's edema, incl. swelling of the larynx.

From the skin: very rarely - rash, itching, urticaria.

If allergic reactions develop, the drug should be discontinued and the drug should not be resumed. Due to the risk of developing anaphylactic shock, in the event of the appearance of respiratory, laryngeal symptoms or skin (itching, generalized erythema) symptoms, immediate intramuscular injection of epinephrine (adrenaline) at a dose of 0.01 mg/kg is recommended. If necessary, repeat IM injection after a minute.

There is limited information on fusafungine overdose.

Symptoms: poor circulation, numbness in the mouth, dizziness, increased sore throat, burning sensation in the throat.

Treatment: In case of overdose, treatment should be symptomatic with subsequent observation.

No specific studies on interactions with other drugs have been conducted.

It is not recommended to exceed the duration of the standard 7-day course of treatment in accordance with the general rules for the use of antibiotics. At the end of the 7-day course of treatment, the patient should consult a doctor to assess the effectiveness of therapy.

May cause skin irritation.

The drug contains a small amount of ethanol, less than 100 mg/dose.

Do not spray the drug into the eyes.

Do not store the drug near strong heat sources.

Do not expose to temperatures above 50°C.

Avoid breaking the seal of the cylinder body and burning it, even after the drug has been completely used.

Impact on the ability to drive vehicles and operate machinery

Bioparox does not affect the ability to drive vehicles and the speed of psychomotor reactions.

There are no clinical data on the use of the drug during pregnancy. The drug should be prescribed with caution during pregnancy.

Due to the lack of data on excretion in breast milk, the use of Bioparox in nursing women is not recommended.

Long -term studies on laboratory animals did not reveal embryo-, genotoxic effects or teratogenic effects on the fetus.

Contraindicated in children under 2.5 years of age.

The drug is approved for use as a means of OTC.

No special storage conditions are required. Shelf life: 2 years. Do not use after the expiration date stated on the package.

To ask a question about the project or contact the editors, use this form.

Source: http://health.mail.ru/drug/bioparox/

Bioparox ® (Bioparox ® )

Active substance:

Content

Pharmacological group

Nosological classification (ICD-10)

Compound

Description of the dosage form

Aerosol aluminum can equipped with a metering valve.

Contents of the container: yellow solution with a specific odor.

pharmachologic effect

Pharmacodynamics

Fusafungin is a topical antibiotic with anti-inflammatory properties.

In vitro, the drug has an antimicrobial effect on the following microorganisms, which suggests a similar effect in vivo group A streptococci , pneumococcus , staphylococci , some strains of Neisseria, some anaerobes, fungi Candida genus (Candida albicans) and mycoplasma pneumoniae (Mycoplasma pneumoniae) .

Fusafungin has a pronounced anti-inflammatory effect by reducing the concentration of tumor necrosis factor (TNF-α) and suppressing the synthesis of free radicals by macrophages while maintaining phagocytosis.

Pharmacokinetics

Fusafungin is mainly distributed in the oropharynx and nasal cavity. In blood plasma, fusafungin can be detected in very low concentrations (no more than 1 ng/ml), which does not affect the safety of the drug.

Indications of the drug Bioparox ®

Treatment of infectious and inflammatory diseases of the upper respiratory tract in adults and adolescents from 12 years of age:

condition after tonsillectomy;

Contraindications

hypersensitivity to the active substance or to the excipients included in the drug;

patients predisposed to allergic reactions and bronchospasm (see “Side effects”);

children under 12 years of age (see “Side effects”).

Use during pregnancy and breastfeeding

There are no clinical data on use during pregnancy. In this regard, the drug should be prescribed to pregnant women with caution.

Long-term studies on laboratory animals did not reveal embryo-, genotoxic effects or teratogenic effects on the fetus.

Due to the lack of data on excretion in breast milk, the use of Bioparox ® is not recommended for nursing women.

Side effects

The following side effects were noted while taking fusafungine with the following frequency: very often (≥1/10); often (≥1/100, <1/10); uncommon (≥1/1000, <1/100); rare (≥1/10000, <1/1000); very rare (<1/10000); unknown frequency (frequency cannot be calculated from available data).

Allergic reactions with the use of fusafungin are very rare, but their development is possible, especially in patients prone to allergies. Severe allergic reactions have also been reported in children (see "Contraindications" and "Special Instructions"). Reactions are most often observed at the site of application of the drug.

From the immune system: very rarely - anaphylactic shock.

From the nervous system: very often - dysgeusia (impaired sense of taste).

From the organs of vision: very often - conjunctival hyperemia.

From the respiratory system, chest and mediastinal organs: very often - sneezing; often - dry nose, dry throat, throat irritation, cough; very rarely - attacks of bronchial asthma, bronchospasm, shortness of breath, laryngospasm, angioedema, incl. swelling of the larynx.

From the gastrointestinal tract: often - nausea; unknown frequency - vomiting.

From the skin and subcutaneous tissues: very rarely - rash, itching, urticaria, Quincke's edema.

If any of the side effects indicated in the description worsen, or the patient notices any other side effects not listed in the description, the doctor should be informed.

Interaction

No special studies have been conducted to study interactions with other drugs.

Directions for use and doses

Locally (for release in the oral cavity and/or nasal passage).

Adults and children over 12 years of age: 4 releases into the mouth and/or 2 releases into each nasal passage 4 times a day.

To make maximum use of the activity of the Bioparox ® drug, it is important to follow the prescribed dose and follow the rules for using the supplied attachments. For a lasting therapeutic effect, it is necessary to observe the duration of the prescribed treatment: it is not recommended to stop treatment when the first signs of improvement appear, because premature cessation of therapy may lead to relapse.

You should always carry the drug with you, placing it in the supplied portable carrying case.

The duration of the usual course of treatment should not exceed 7 days.

At the end of the course of therapy, you should consult a doctor to assess the effectiveness of treatment.

If symptoms of the disease and/or elevated temperature persist during therapy with Bioparox ®, you must inform your doctor about this.

In the case of pronounced clinical manifestations of a bacterial infection, treatment with Bioparox ® in combination with systemic antibiotics is possible.

Method of use of the drug Bioparox ®

1. Before the first use, to activate the cylinder, press its base 4 times.

2. Place the appropriate nozzle on the balloon: (white, for inhalation of the drug through the mouth (2) or yellow, for administration through the nose) (Fig. 1).

Use of the drug through the nose (for rhinitis, nasopharyngitis, sinusitis):

The container with the drug must be held vertically with the nozzle upward, holding it between the thumb and forefinger.

1. Clean your nose before using the drug.

2. Attach the yellow nozzle to the balloon and insert it into the nasal passage (while holding the opposite nasal passage and closing the mouth). Do not inhale when using.

3. Press the base of the cylinder twice vigorously and all the way, holding the cylinder in a vertical position (Fig. 2).

Use of the drug by mouth (for pharyngitis, tonsillitis, condition after removal of tonsils, laryngitis)

Place the white nozzle on the balloon (Fig. 3) and insert it into your mouth, pressing it tightly with your lips. Hold the cylinder as shown in Fig. 4. Do not inhale when using.

Hold the cylinder vertically and vigorously press the base of the cylinder 4 times until it stops, as shown in Fig. 4.

Nozzles for the mouth and nose must be disinfected every other day using a cotton swab soaked in 90% ethyl alcohol.

Overdose

There is limited information on fusafungine overdose.

Symptoms: poor circulation, numbness in the mouth, dizziness, increased sore throat, burning sensation in the throat.

Treatment: in case of overdose, treatment should be symptomatic, followed by observation.

special instructions

Excessive prolonged use of the drug can lead to the development of superinfection. It is not recommended to exceed the duration of the standard 7-day course of therapy in accordance with the general rules for the use of antibiotics. At the end of the 7-day course of therapy, you must consult a doctor to assess the effectiveness of treatment. If symptoms and clinical signs of the disease do not improve within 7 days of therapy, alternative treatment should be considered. Propylene glycol may cause skin irritation.

If allergic reactions develop, the drug should be discontinued and the drug should not be resumed.

Due to the risk of anaphylactic shock, if respiratory, laryngeal or skin symptoms (itching, generalized erythema) occur, immediate intramuscular administration of epinephrine (adrenaline) may be required. The recommended dose is 0.01 mg/kg IM. If necessary, the intramuscular injection can be repeated after 15–20 minutes.

The drug contains a small amount of ethanol, less than 100 mg/dose. Do not spray the drug into the eyes. Do not store the drug near strong heat sources. Do not expose to temperatures above 50 °C.

Avoid breaking the seal of the cylinder body and preventing it from burning even after the drug has been completely used.

Influence on the ability to drive vehicles and machinery. Bioparox ® does not affect the ability to drive a car or the speed of mental and physical reactions.

Release form

Aerosol for topical use dosed, 0.125 mg/release. 10 ml of solution in an aluminum aerosol can. 400 releases (100 doses) per aluminum container. The cylinder has a dosing valve, equipped with two spray nozzles: for the nose (yellow) and mouth (white), and an activator cap. One bottle with spray nozzles and an activator cap in a blister pack with a case for portable carrying and instructions for medical use in a cardboard box.

Manufacturer

The registration certificate was issued to Servier Laboratories, France.

Produced by: Closed Joint Stock Company Pharmaceutical Plant EGIS, Hungary.

Closed Joint Stock Company Pharmaceutical Plant EGIS, Hungary: 9900, Körmend, st. Matyas Kiraly 65, Hungary.

9900 Kormend, Matyas kiraly ut 65, Hungary.

For any questions, please contact the Representative Office of Servier Laboratories JSC.

Representative office of JSC Servier Laboratories:

115054, Moscow, Paveletskaya square, 2, building 3.

Tel.: , fax: .

Conditions for dispensing from pharmacies

Storage conditions for the drug Bioparox ®

Keep out of the reach of children.

Shelf life of the drug Bioparox ®

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

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Bioparox spray - instructions for use and reviews

Bioparox is an effective inhalation drug that is used for the rapid treatment of infectious and inflammatory diseases of the respiratory tract. This product contains the active substance fusafungin, a broad-spectrum polypeptide antibiotic. Instructions for use ✅ Bioparox indicates that the drug ✅ has a bacteriostatic effect against pathogenic organisms and fungi.

That is, the medicine has a powerful antiviral and anti-inflammatory effect. Bioparox will help quickly eliminate symptoms such as runny nose, tonsillitis, pharyngitis, sore throat, and nasal congestion. The drug also effectively fights bronchitis, colds and prevents the development of pneumonia and sinusitis.

Bioparox - description and properties

Bioparox is an antibiotic intended for topical use. The drug is produced by the French pharmaceutical company Laboratory Servier in the form of a convenient aerosol bottle (20 ml). The bottle is designed for 400 doses. The medicine comes with special attachments for adults and children.

The active medicinal substance of the drug is fusafungin, which stops the vital activity of pathogenic organisms and the further reproduction of pathogens. Bioparox is active against bacteria that cause diseases of the upper respiratory tract and nasopharynx - yeast-like fungi, staphylococci, streptococci. A feature of this drug is the instability of bacteria to the drug.

The medication has a pronounced antifungal and antibacterial effect. The medicine eliminates inflammation, lowers protein concentrations in tissues, and suppresses toxic free radicals. With properly prescribed therapy, Bioparox penetrates into the farthest parts of the respiratory tract. Directly during the aerosol inhalation procedure, most small particles are retained on the walls of the mucous membrane of the nasopharynx, penetrate deeply into its tissues, into the nasal sinuses and eliminate nasal congestion, swelling of the mucous membrane, and discharge from the nasal passages.

When inhaled, the active drug substance practically does not penetrate into the bloodstream, but only reaches the superficial tissues of the nasopharynx. The drug can be detected in the blood only in small quantities, so the drug does not have a general effect on the body. It is non-toxic and completely safe.

The drug contains medicinal components that help eliminate infection and prevent the development of complications in the disease.

The drug is an oily liquid with a slight characteristic yellow odor. The medicine is available in an aluminum bottle with a convenient dosing valve. The product comes with three nozzles of different colors. The yellow nozzle is intended for primary use, white - for inhalation through the mouth, transparent - for children's inhalation through the nasal passages. One bottle contains 400 doses.

Indications for use

  • acute tonsillitis;
  • angina;
  • chronic tonsillitis;
  • pharyngitis;
  • sinusitis;
  • sinusitis;
  • laryngitis;
  • postoperative therapy for tonsil removal;
  • acute nasopharyngeal infections;
  • respiratory tract infections.

The drug is available without a prescription. Shelf life: two years.

Bioparox spray is intended for inhalation. They must be carried out with a deep breath, which will allow the particles of the drug to penetrate to the bronchioles (small bronchi). This medicine is widely used to treat respiratory tract and ENT diseases. It quickly and effectively cures colds in adults and children and is recommended for use in complex therapy.

It is important to start treatment with the drug in a timely manner, this will prevent further spread of the infection and the development of complications. The medicine is also used to prevent sinusitis due to a runny nose.

Bioparox and sore throat

The drug is also widely used in the treatment of sore throat. The inflammatory process in this disease begins in the palatine tonsils and is of bacterial origin. Typically, the disease begins with catarrhal manifestations - redness and swelling of the mucous membranes. Inflammation can develop into purulent or follicular sore throat. In the lacunar form of the disease, pus begins to accumulate in the lacunae of the tonsils. Follicular ulcers may appear on the surface of the tonsils.

The medicinal spray copes well with sore throat at the very beginning of its development, in the phase of the catarrhal inflammatory process. If a sore throat is caused by a pathogen that is sensitive to the drug, then Bioparox will quickly stop the development of the disease. If your condition does not improve within three days, systemic treatment is required. Bioparox is not often prescribed for angina. More widely, it is used only at the initial stage of the disease, as well as in the treatment of chronic tonsillitis and inflammation of the tonsils. The use of the drug is indicated at the initial stage of angina. If a purulent sore throat develops, the doctor prescribes general therapy with other medications.

Bioparox copes well with exacerbations of chronic tonsillitis, since it is an effective antibiotic that is designed to fight infection. The drug actively affects bacteria, preventing their vital activity and reproduction. As a result of treatment with the drug, sore throat, sore throat, redness and swelling of tissues are eliminated. The drug can be used repeatedly during the day.

Bioparox and sinusitis

If a complication such as sinusitis develops, the medicine is also prescribed in the initial stages. Sinusitis is an inflammation of the paranasal sinuses. The acute course of the disease manifests itself as a complication of a respiratory infection. Next comes a bacterial infection. Bioparox helps prevent the development of complications and blocks the proliferation of pathogenic bacteria.

The main signs of the onset of sinusitis are nasal congestion and swelling, headache, and fever. Bioparox eliminates all these symptoms and effectively helps cope with the onset of sinusitis. Acute sinusitis cannot be cured with Bioparox alone. Therefore, with this diagnosis, the drug is used in complex therapy with other drugs. If health improvement does not occur within three days, the doctor will prescribe general antibiotics.

Instructions for use

This product is used as inhalation through the mouth or nasal passages. Before starting the procedure, you need to activate the bottle by pressing the valve. For rhinitis, sinusitis, and nasopharyngitis, the medicine is injected into each nostril. Before treatment, it is necessary to clear the nasal secretions.

A nozzle is put on the can, after which it must be taken in your hand. The cylinder should be held vertically. The nozzle is carefully inserted into the nostril. The second nostril is closed with your free hand. Then inhale, after which you need to press the base of the canister to inject the medicine into the nasal passage. The procedure must be carried out with the mouth closed. Inhalation must be done through the nose.

For infections of the throat and upper respiratory tract, inhalation is carried out through the mouth. A white nozzle is put on the can. The can is held vertically in the hand. The nozzle is inserted into the mouth and clamped with the lips. You need to take a deep breath through your mouth and press the spray dispenser. To completely irrigate the upper respiratory tract, it is necessary to hold your own breath after the medicine is sprayed into the oral cavity.

During procedures, it is important to constantly disinfect the attachments used.

The dosage of the medicine and the duration of therapy are prescribed by the attending physician. Application scheme:

  • Children over 2 years old are advised to inject 2-4 doses (for inhalation directly through the mouth) or 1-2 doses (for inhalation through the nasal passages) 4 times a day.
  • For children over 12 years of age and adults, doctors prescribe 4 doses of the drug (for inhalation through the mouth) or 2 doses (for inhalation through the nasal passages) four times a day.
  • for mixed infections, the doctor may prescribe inhalations both through the mouth and through the nasal passages;
  • treatment should not exceed seven days.

Reviews of the use of Bioparox indicate that the drug is well tolerated by the body and rarely causes side effects. Those patients who used this remedy in the treatment of the disease noted a significant improvement in their well-being, elimination of sore throat and nasal discharge. The drug is quickly absorbed into the mucous membrane and begins its medicinal effect almost instantly.

Side effects

Side effects in rare cases may include:

If any side effects occur, you should consult your doctor. It is possible that he will change the drug to another drug.

Bioparox for children

In pediatrics, Bioparox can be used starting from the age of two. The drug is not prescribed to younger children due to the increased risk of laryngospasm. A spasm of the glottis can be very dangerous - in such a situation, the child cannot inhale and exhale. Therefore, the drug should be prescribed with great caution and inhalation should be monitored.

It is advisable not to use the medication in treatment if there is any allergic reaction. The drug is low-toxic and well tolerated by children. The main contraindication to the use of the drug is hypersensitivity to the components of the drug. The course of treatment should not exceed seven days.

During pregnancy

There are currently no clinical data on the use of Bioparox during pregnancy. However, animal studies did not reveal any genotoxic effects or negative effects on the developing fetus. The drug should be prescribed with caution during pregnancy.

When prescribing a drug during pregnancy, the doctor must take into account the possible risks of fetal development and benefits for the mother. At the same time, it is necessary to monitor the well-being of the expectant mother. At the first negative manifestations and side effects, the use of the drug must be stopped.

The spray contains the antibiotic fusafungine. When administered by inhalation, it is not detectable in the blood. According to the instructions, the drug can be used during pregnancy only as prescribed by a doctor. You should be aware that taking any drug is associated with certain risks.

In early pregnancy, due to the low absorption of the active drug substance, the drug cannot have a negative effect on the fetus. A developing infection can cause much more harm, so it needs to be eliminated as soon as possible. The use of the drug in the first trimester of pregnancy requires mandatory subsequent examination of the fetus.

In the second trimester, the mother's cold is no longer so scary for the fetus. The unborn child's organs are already formed, and the virus no longer has a big impact on its development. In the third trimester, the development of infection can provoke premature birth. Treatment with Bioparox will prevent the development of the disease and reduce the risk of premature birth to a minimum. However, you should not use the drug uncontrolled during pregnancy.

It is not recommended to use Bioparox during lactation, since it is unknown whether the drug passes into breast milk.

Analogs and price

Almost all analogues of the drug are cheap. Drugs with similar interactions include:

Cost of the original and analogues:

  • Bioparox – 460 rubles;
  • Grimicidin – 140 rubles;
  • Isofra – 250 rubles;
  • Grammidin - 170 rubles.

The drug Bioparox is assessed by doctors as a fast-acting remedy. The active substance that is part of the drug affects only the upper respiratory tract and does not enter the bloodstream. This allows the spray to be used in the treatment of pregnant women and children.

It is very important to start treatment with the drug at the first signs of the disease in order to prevent further spread of the infection and the occurrence of complications. A convenient dispenser eliminates the possibility of overdose. Side effects of the drug and contraindications to the use of the drug are minimized.

Reviews about the application

I recently suffered from very severe pharyngitis. My throat hurt and it was impossible to swallow food or drink water. The doctor prescribed Bioparox, which turned out to be a very effective medicine.

Inhalations are very convenient to do. Already on the second day, the sore throat became significantly weaker and lost its intensity. Good product, quickly cures infection.

Sergey, 45 years old - Novosibirsk

Review #2

I used Bioparox to treat a sore throat in my eight-year-old daughter. It was an ordinary sore throat, not purulent. Inhalations of this drug helped a lot, the sore throat went away immediately, and my daughter began to recover quite quickly. I liked the effect of the drug. Now I will know how to treat a child’s throat well.

Alexandra, 34 years old - Kazan

Review #3

We gave our two-year-old son inhalations with Bioparox. A high-quality drug that quickly, in just a couple of days, removes a runny nose and sore throat.

Restores mucous membranes well. The child tolerated treatment with this medicine well and did not develop any allergies or fever.

Kirill, 22 years old - St. Petersburg

Review No. 4

I recently used Bioparox myself. My throat was very sore, a therapist friend advised me to treat myself with this remedy. The medicine quickly eliminates swelling and pain. I used the drug for only five days, everything went away.

The soreness disappeared, and within a week there was no trace of the disease left. A good product that has a convenient dispenser and special attachments. They are very comfortable to use for treatment, nothing complicated. I recommended it to my sister to treat a runny nose and sore throat.

Veronica, 31 years old - Moscow

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Source: http://glavvrach.com/bioparoks/

Bioparox

Description current as of 10/16/2015

  • Latin name: Bioparox
  • ATX code: R02AB03
  • Active ingredient: Fusafungin (Fusafunginum)
  • Manufacturer: Les Laboratoires Servier, France

Compound

The drug contains fusafungin (the concentration of the substance in one dose is 0.125 mg), as well as flavoring (additive 14868), anhydrous ethanol, saccharin, isopropyl myristate, and norflurane (propellant).

Aroma additive composition: ethanol 96%, anise alcohol; oils (anise, tarragon and wormwood); extracts of caraway fruits, clove buds, coriander seeds, field mint, peel of sweet orange fruits, bitter orange, allspice fruits, pharmaceutical rosemary flowers; vanilla resinoid, methyl anthranilate, ethyl vanillin, propylene glycol, phenylethanol, heliotropin, geraniol, lignin-based vanillin, linalol, indole, isopropyl myristate, terpineol.

Release form

Aerosol for inhalation dosed.

One cylinder contains 400 releases, one dose per release. Each release corresponds to 0.125 mg of active substance.

The drug is a characteristically smelling, transparent, oily liquid of pale yellow color. It is produced in aluminum containers with a volume of 20 ml (package No. 1). Each container is equipped with a dosing valve and has three replaceable nozzles: yellow - for nasal use, white - for inhalation through the mouth, transparent - for nasal use in children.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

Is fusafungin an antibiotic or not?

Wikipedia to the question “Fuzafungin - what is it?” answers that the substance is a local polypeptide antibiotic with anti-inflammatory activity. It is obtained from strain 437 of the Fusarium lateritium fungus culture.

The drug is effective against Gram (+) bacteria (group A streptococci (Str. pyogenes), Str. pneumoniae, Staphylococcus spp.); Gram (-) bacteria (including certain strains of Neisseria, Legionella pneumophila, Moraxella catarrhalis, Haemophilus influenzae); some anaerobes, fungi of the genus Candida, mycoplasmas (Mycoplasma spp.).

Pharmacodynamics

When administered by inhalation, fusafungine settles on the surface of the mucous membrane of the external respiratory system; the substance is not detected in the blood plasma. The aerosol form provides complete coverage of the mucous membrane of the respiratory tract and penetration into the bronchioles and sinuses.

After four times inhalation through each nasal passage or through the mouth, the concentration of fusafungine in the bronchi and trachea reaches 0.04, in the nasal cavity - 0.06, and in the lungs - 0.08 mg/ml.

The drug reduces exudation, relieves swelling and inflammation of the mucous membrane of the respiratory system, improves nasal breathing. Practical experience shows that the effectiveness of therapy is higher if treatment with Bioparox is started early.

Fusafungine does not reduce the effectiveness of antimicrobials for systemic use. There are no reports of cross-resistance or acquired resistance.

Pharmacokinetics

After use in the form of inhalation, the drug is distributed mainly on the surface of the mucous membrane in the nose, oral cavity and pharynx. The concentration of the substance in the blood plasma does not exceed 1 ng/ml and does not affect the safety of Bioparox.

Indications for use

The feasibility of using Bioparox for angina

For angina, Bioparox is not always used. Sore throat (or acute tonsillitis) is an infectious disease with local manifestations of inflammation in the area of ​​the 1st and 2nd tonsils.

Reviews about Bioparosk for sore throat are good. However, the drug can only be used at the catarrhal stage of inflammation - with redness and swelling of the palatine tonsils, that is, when the inflammatory process has just begun.

In addition, Bioparox is widely used to treat exacerbations of chronic tonsillitis, which in most cases are not as severe as tonsillitis.

If acute tonsillitis is complicated by the appearance of pustules, the use of topical antibiotics does not make sense. If there is no improvement after three days of treatment or the patient’s condition worsens, the drug is discontinued and the patient is prescribed systemic antibiotics.

Using Bioparox spray for sinusitis

For sinusitis, the spray is effective only in the initial stages of the disease. Sinusitis is an acute or chronic inflammation of the paranasal sinuses. Acute sinusitis usually develops against the background of acute respiratory viral infection, complicated by a bacterial infection.

The first symptoms of the disease are persistent long-term nasal congestion, headache and high fever. Acute sinusitis, like acute tonsillitis, cannot be cured with Bioparox alone. The effect of using the drug is possible only in the very early stages of inflammation.

If after 2-3 days of treatment the patient does not feel improvement, systemic antibiotics will most likely be required.

Contraindications

The drug has virtually no contraindications. Limitations to its use are intolerance to fusafungin or any of the auxiliary components of the spray, as well as early childhood (up to 2.5 years).

The spray should be used with caution in patients prone to bronchospasm and allergies.

Side effects

Sometimes (very rarely) side effects may occur, such as increased dryness in the nose/throat, dysgeusia, sneezing, throat irritation, nausea, and cough.

These reactions are transient and do not require cessation of treatment.

Sometimes, especially in patients prone to allergies, local reactions of the skin and subcutaneous tissue, reactions of the mucous membrane (redness, swelling), bronchospasm, and superinfection may occur. In such cases, treatment with Bioparox should be discontinued.

If symptoms appear in the respiratory system, skin or larynx, due to the risk of anaphylactic shock, it may be necessary to urgently administer epinephrine (adrenaline) at a dose of 0.01 mg/kg. Method of administration: intramuscular injection. In some situations, repeated administration of adrenaline may be necessary. The drug is administered in the same dose after about 20 minutes.

Spray Bioparox: instructions for use

Instructions for use of Bioparox in adults

The standard dose of the drug for infectious and inflammatory diseases of the respiratory system (bronchitis, pharyngitis, tracheitis, etc.) for adult patients (including adolescents and the elderly) is four injections through the mouth and/or two injections into each nasal passage 4 r ./day

Spray Bioparox: instructions for use for children

Due to the risk of developing laryngospasm, Bioparox for children can only be used from 2.5 years.

A single dose of Bioparox for children from 2.5 to 11 years old - one injection into each nasal passage or two injections into the mouth. Frequency of applications - 4 rubles/day.

Many mothers leave good reviews about Bioparox spray. In their opinion, the drug very quickly helps with pharyngitis and sore throat, but can cause adverse reactions in the form of a burning sensation in the throat and allergic stomatitis.

Some are afraid to use Bioparox for children, remembering the inappropriateness of topical use of antibiotics.

Dr. Komarovsky gives an explanation on this matter in his blog: it is forbidden to instill antibiotics that are intended for systemic use into the nose, but fusafungin contained in Bioparox is not systemic, therefore, it can definitely be used topically, and doctors who prescribe a spray for children in no way violate pharmacological principles and norms of modern medicine.

Overdose

No overdose was observed with topical use of fusafungin.

Interaction

Drug interactions of fusafungin (including with other antibiotics) have not been studied.

Terms of sale

Storage conditions

The aerosol container must not be exposed to temperatures above 50°C. Avoid leaking the container and storing the drug near intensely emitting heat sources.

Best before date

special instructions

Due to the possibility of relapse, it is not recommended to stop using Bioparox immediately after the first signs of improvement appear.

Long-term use of the drug can cause an imbalance in microflora and the spread of superinfection.

Lack of improvement after a week of treatment is a reason to consider alternative therapy.

The fragrance contains propylene glycol, which may cause skin irritation.

The spray contains a small amount of ethanol (less than 0.1 g/dose).

Features of using an aerosol can

Before using Bioparox for the first time, to fill the dosing mechanism, press the main nozzle 4 times. After this, the nozzle on the container is replaced with the desired one: white - for the mouth, yellow - for the nose, transparent - children's for the nose.

Before using the spray, you need to clean your nasal passages. Holding the container in a vertical position, insert the nozzle into each nasal passage one by one and make the required number of injections. In this case, the mouth and other nasal passage should be closed.

In case of use through the mouth, a white nozzle is inserted into the mouth, lips are compressed around it and, lightly pressing on the bottom of the can, an injection is made (you need to breathe as usual during injection).

The container must be disinfected daily. The treatment is carried out once a day, using cotton wool soaked in a solution of ethyl alcohol (90%).

Analogues of Bioparox

Price of Bioparox analogues

Almost all analogues are cheaper than Bioparox. Grimicidin tablets (No. 20) cost an average of rubles, Isofra nasal spray - from 240 rubles, Grammidin - from 165 rubles.

Bioparox and alcohol - compatible or not?

During treatment with the drug, alcohol is contraindicated.

Bioparox during pregnancy and breastfeeding

Is it possible to use Bioparox during pregnancy?

The spray contains the antibiotic fusafungin, which is not detectable in blood plasma when administered inhaled.

The manufacturer, in the annotation for the drug, when asked whether pregnant women can take inhalations with Bioparox, answers that during pregnancy the drug can be used, but only with the approval of the attending physician and if there are indications.

Animal studies did not reveal any negative effects (direct or indirect) on the course of pregnancy/childbirth, as well as on the development of the child in the prenatal period and during infancy. The use of the drug did not reduce fertility in female and male rats.

Please remember that taking any medications during pregnancy carries certain risks. As for the spray, there are no clinical data that would confirm the safety of its use in pregnant women.

Why is Biparox prescribed during pregnancy?

Due to the extremely low absorption of fusafungin, the likelihood that the drug will cause fetal developmental disorders is extremely low, even if Bioparox is used in early pregnancy.

In this case, the spray can cause much less harm than an infection, since the most common acute respiratory viral infection suffered by the mother in the first weeks of pregnancy often leads to a miscarriage or the development of defects incompatible with life.

However, if it is necessary to use it in the 1st trimester (especially in the first 8-9 weeks), after completion of treatment it is recommended to check how correctly the fetus is developing.

In the 2nd trimester, colds are not so scary for a child. By this time, the child has already formed all the vital organs, so viruses no longer have a fatal effect. However, a cold that is not treated in time can cause fetal hypoxia and damage to the nervous system.

Oxygen starvation can lead to both a slight slowdown in development and cerebral palsy or dangerous underdevelopment of the brain.

In the 3rd trimester, a cold can trigger premature labor. Timely use of Bioparox allows you to minimize this risk and also prevents the risk of hypoxia.

Reviews of Bioparox during pregnancy are good: the drug very quickly eliminates inflammation, makes breathing easier and relieves sore throat. Mothers who used it at different stages of pregnancy note that the treatment did not affect the health of their children in any way - their babies were born strong and healthy. However, despite all the safety of fusafungin, it is still not worth using it uncontrolled.

Use during lactation

When feeding, the use of Bioparox is possible if indicated.

It is unknown whether the active substance of the drug penetrates milk during breastfeeding. The decision to stop or continue breastfeeding/therapy is made taking into account the benefits of the first for the child and the second for the mother.

The ability of fusafungine to pass into breast milk has not been studied in animal studies.

Reviews about Bioparox

Many people evaluate Bioparox as a fast-acting and very effective remedy for infectious and inflammatory diseases of the respiratory system. The active substance of the drug acts only on the surface of the mucous membrane of the ENT organs and respiratory tract, which allows the spray to be used during pregnancy and in pediatric practice.

The drug is effective against bacterial pharyngitis, bronchitis and rhinitis. However, only if used correctly: for sore throat and sinusitis, Bioparox can only help if it is started to be used immediately after the first symptoms of the disease appear.

Reviews about Bioparox for children are quite contradictory. Some mothers praise the medicine for the fact that it quickly copes with cough, runny nose, redness and sore throat. Others call it completely useless.

The disadvantages of the spray, in their opinion, are also its specific taste and pungent smell, which children often do not like, the presence of side effects (burning and dry throat), and high price.

Based on patient reviews, we can draw the following conclusion that the drug can act completely differently on different people, so it should be used only with the approval of the attending physician and taking into account the patient’s response to the prescribed treatment.

How much does Bioparox cost? The cost of the spray in Russian and Ukrainian pharmacies

Bioparox price in Ukraine

The price for Bioparox spray in Ukrainian pharmacies varies from 83 to 112 UAH.

Price of Bioparox in Russian pharmacies

In Russian pharmacies the drug can be bought for an average of 465 rubles.

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BIOSPHERE

This is the best drug. Now without him I will have to be sick for a long time.

What idiot banned the release of bioparox, I was only saved by it, now I don’t know what to do.

The drug Bioparox, in Russia, has long been recalled by the manufacturer. Possible(!) serious side effect.

I recently had a bad cold. My throat hurt terribly, it was painful to eat and even talk. At the appointment, the doctor prescribed Bioparox 3 sprays 3 times a day. After 3 days, my throat didn’t seem to hurt at all.

Konstantin: What I liked about the drug Prostanorm: reasonable price, pronounced effect of taking it.

Valentina: I, too, am all about diet and exercise. I hoped for loads, I thought that my healthy lifestyle.

Nina: I was on pills for a year and a half, then somehow everything calmed down. Mostly climatefit.

Elena: With the onset of menopause, the skin completely deteriorated and became dry. I saw a cream for .

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Source: http://medside.ru/bioparoks