Augmentin for children

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Augmentin in suspension form: instructions for use for children

Augmentin is a combination drug of the penicillin group of synthetic antibiotics with a broad spectrum of action.

Intended for treatment of adults and children.

Table of contents:

Augmentin contains the active substances amoxicillin trihydrate and potassium clavulanate (clavulanic acid).

Augmentin is available in tablets, syrup, powder for injection, and dry substance for preparing suspensions. Syrup and suspension are intended for the treatment of children under 12 years of age. This form of the drug is quite easily tolerated even by the smallest patients. However, caution must be exercised when taking it, as there is a risk of allergic reactions.

On this page you will find all the information about Augmentin: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews from people who have already used Augmentin in the form of a suspension. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

A broad-spectrum penicillin antibiotic with a beta-lactamase inhibitor.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

How much does Augmentin suspension cost? The average price in pharmacies is:

  • Augmentin powder for preparing a suspension 125/31.25 – 118 – 161 rubles;
  • Augmentin powder for preparing a suspension 200/28.5 – 126 – 169 rubles;
  • Augmentin powder for preparing a suspension 400/57 – 240 – 291 rubles;
  • Augmentin EC powder for preparing a suspension 600/42.9 – 387 – 469 rubles;

Release form and composition

The medication consists of:

  1. Amoxicillin (it is represented by trihydrate);
  2. Clavulanic acid (it comes in the form of potassium salt).

Available in different forms:

  1. Powder. It is intended for the production of oral suspension. The following excipients are used: dry flavors (orange, “Light molasses”, raspberry), succinic acid, colloidal silicon dioxide, xanthan gum, hydroxypropyl methylcellulose, aspartame. Contains powder inside the bottles. The bottle is placed in a package made of cardboard.
  2. Pills. The following substances were used in their creation: silicon dioxide (colloidal anhydrous), sodium starch glycolate, titanium dioxide, cellulose (microcrystalline), dimethicone 500, magnesium stearate, macrogol, hypromellose (5, 15 cps). Packed in 7, 10 tablets per blister. Inside a pack of such blisters (made of foil) there is a pair.

The powder intended for the production of a suspension is produced in the UK (SmithKline Beecham Pharmaceuticals).

Pharmacological effect

A bacteriolytic effect was noted. The medication is active against aerobic/anaerobic gram-positive and aerobic gram-negative microorganisms. It is very effective against strains that are capable of producing beta-lactamase. Under the influence of clavulanic acid, the resistance of amoxicillin to the influence of a substance such as beta-lactamase increases. At the same time, an expansion of the influence of this substance is observed.

The drug is active against:

  • Legionella;
  • Yersinia enterocolitica;
  • Streptococcus pneumoniae;
  • Fusobacterium;
  • Bordetella pertussis;
  • Peptococcus spp.;
  • Bacillus anthracis;
  • Peptostreptococcus spp.;
  • Enterococcus faecium;
  • Streptococcus agalactiae;
  • Vibrio cholerae;
  • Listeria monocytogenes;
  • Borrelia burgdorferi;
  • Moraxella catarrhalis;
  • Streptococcus;
  • Proteus mirabilis;
  • Peptococcus spp.;
  • Leptospira icterohaemorrhagiae;
  • Streptococcus pyogenes;
  • Neisseria meningitidis;
  • Treponema pallidum;
  • Helicobacter pylori;
  • Brucella spp.;
  • Streptococcus viridans;
  • Gardnerella vaginalis;
  • Haemophilus influenza.

When prescribing medicine to a child, the doctor must calculate the required amount of suspension for him.

Indications for use

Augmentin is prescribed for bacterial infections caused by microorganisms that are sensitive to the antibiotic:

  • infections of bones and joints: osteomyelitis;
  • odontogenic infections: periodontitis, odontogenic maxillary sinusitis, severe dental abscesses;
  • infections of the skin, soft tissues;
  • respiratory tract infections: bronchitis, lobar bronchopneumonia, empyema, lung abscess;
  • infections of the genitourinary system: cystitis, urethritis, pyelonephritis, abortion sepsis, syphilis, gonorrhea, infections of organs in the pelvic area;
  • infections that arise as a complication after surgery: peritonitis.

The medication is also used in therapy and prevention of infectious complications that can occur during operations on the gastrointestinal tract, neck, head, pelvis, kidneys, joints, heart, bile ducts.

Contraindications

All dosage forms of Augmentin are contraindicated for use if a person has the following conditions or diseases:

  • Allergic reaction or hypersensitivity to amoxicillin, clavulanic acid or antibiotics from the penicillin or cephalosporin group;
  • Development of jaundice and liver dysfunction in the past during the use of drugs containing amoxicillin and clavulanic acid.

Some dosage forms of Augmentin, in addition to those indicated, have the following additional contraindications:

1. Suspension 125/31.25:

2. Suspensions 200/28.5 and 400/57:

  • Phenylketonuria;
  • Creatinine clearance less than 30 ml/min;
  • Age less than 3 months.

3. Tablets of all dosages (250/125, 500/125 and 875/125):

  • Age under 12 years or body weight less than 40 kg;
  • Creatinine clearance less than 30 ml/min (only for tablets 875/125).

Instructions for use

Children under 12 years of age or weighing less than 40 kg should take Augmentin only in suspension form. In this case, babies under 3 months can only be given a suspension with a dosage of 125/31.25 mg. In children over 3 months of age, it is allowed to use suspensions with any dosage of active ingredients. It is precisely because Augmentin suspension is intended for children that it is often called simply “children’s Augmentin” without indicating the dosage form (suspension). The dosage of the suspension is calculated individually based on the age and body weight of the child.

The instructions for use indicate that the required amount of the finished suspension (solution) is measured using a measuring cup or syringe. To take the medicine to children, you can mix the suspension with water in a one to one ratio, but only after the required dosage has been determined.

  1. In order to reduce discomfort and side effects from the gastrointestinal tract, it is recommended to take tablets and suspension at the beginning of meals. However, if for some reason this is not possible, then the tablets can be taken at any time in relation to food, since food does not have a significant effect on the effects of the drug.
  2. Taking tablets and suspensions, as well as intravenous administration of Augmentin solution should be done at regular intervals. For example, if you need to take the drug twice a day, then you should maintain the same 12-hour interval between doses. If you need to take Augmentin 3 times a day, then you should do this every 8 hours, trying to strictly observe this interval, etc.

To calculate the amount of the drug, you must use the following standards:

Suspension 200 mg.

  • Up to one year, weight from 2 to 5 kg. – 1.5 – 2.5 ml 2 times a day;
  • From 1 to 5 years, weight from 6 to 9 kg – 5 ml 2 times a day.

Suspension 400 mg.

  • Children from one year to 5 years, weight from 10 to 18 kg – 5 ml 2 times a day;
  • From 6 to 9 years old, weighing from 19 to 28 kg -7.5 ml 2 times a day;
  • Children 10 to 12 years old, weight 29 to 39 kg – 10 ml twice a day.

Suspension 125 mg.

  • Up to one year, weight from 2 to 5 kg – 1.5 – 2.5 ml 3 times a day;
  • Children from one year to 5 years, weight from 6 to 9 kg - 5 ml three times a day;
  • From one year to 5 years, weight from 10 to 18 kg – 10 ml 3 times a day;
  • From 6 to 9 years, weight from 19 to 28 kg – 15 ml 3 times a day;
  • From 10 to 12 years, weight from 29 to 39 kg - 20 ml 3 times a day.

The dosage of the drug is calculated depending on the type of infection, stage of progression, weight and age of the patient. It must be remembered that only a doctor can prescribe the required dosage to the patient. When calculating the dosage, it is recommended to take into account only the content of amoxicillin sodium.

Rules for preparing the suspension

The suspension must be prepared immediately before taking the drug. Cooking rules:

  1. Add 60 ml of boiled water at room temperature to the container with the powder, close the lid and shake until the powder is completely dissolved. Next, you need to let the container stand for 5 minutes, this ensures complete dissolution of the drug.
  2. Add water to the mark on the medicine container and shake the bottle again.
  3. For a dose of 125 mg/31.25 mg, 92 ml of water will be required; for a dose of 200 mg/28.5 mg and 400 mg/57 mg, 64 ml of water will be required.

The container with the medicine must be shaken thoroughly before each use. In order to ensure accurate dosing of the medicine, it is recommended to use the measuring cap included in the kit. The measuring cap must be thoroughly cleaned after each use.

The shelf life of the finished suspension is no more than 1 week in the refrigerator. The suspension must not be frozen.

For patients under 2 years of age, the finished single dose of the drug can be diluted with boiled water 1:1.

Side effects

The antibiotic is considered safe for children. The drug has been tested for many years, due to this, its mechanism of action has been quite well studied. Naturally, side effects may occur, but the likelihood of their occurrence is quite low.

  • The following negative reactions may occur from the digestive system: vomiting, nausea, diarrhea. Diarrhea is a common side symptom when taking an antibiotic. When using the suspension, the color of the enamel on the child’s teeth may change; this does not pose a great danger.
  • In certain cases, various allergic reactions may occur. Among them: anaphylactic shock, dermatitis, vasculitis, Stevens-Johnson disease. In certain cases, an allergic rash, erythema, and urticaria develops. The child may experience severe headache and dizziness.

A complete list of side effects of Augmentin for children can be read in the instructions for the drug. The instructions for use also contain a complete list of recommendations and dosages on how to carry out a course of antibiotic treatment.

To protect the child’s body from these undesirable effects, it is necessary to strictly adhere to the dosage of the drug prescribed by a qualified specialist.

Overdose

An overdose is manifested by dehydration, disruption of the digestive tract, and disturbances in the concentration of electrolytes in the blood.

In this case, symptomatic therapy is indicated to support the condition of the baby’s internal organs. To avoid it, you need to follow the instructions strictly and do not exceed the dose of the drug.

Drug interactions

  1. When prescribed with anticoagulants (indirect), the effectiveness of these drugs will increase.
  2. Combined use with antacids, laxatives or glucosamine impairs the absorption of amoxicillin.
  3. The suspension can be used together with nitrofurans, for example, the drug Enterofuril.
  4. Augmentin should not be given to a child together with allopurinol, as this combination can cause skin allergies.
  5. The drug is not prescribed together with methotrexate, since penicillins increase its toxicity.
  6. When prescribed simultaneously with macrolides (for example, with Sumamed or Azitrox suspension), the effect of Augmentin will be weaker. The same effect is observed when combined with tetracyclines, sulfonamides, lincosamides and chloramphenicol.

Reviews

Most of the parent reviews about Augmentin suspension are positive. Mothers note that this antibiotic helps cope with many infections and is well tolerated by most children. They confirm that the treatment begins to work quickly when there is a high fever, cough and other symptoms of infection. Within a few days from the start of treatment, the child’s condition improves.

Negative reviews complain about side effects of the drug, such as nausea or diarrhea. Pediatricians, including Komarovsky, speak mostly well of this antibacterial agent, but they emphasize that only a doctor should prescribe such a suspension to a child.

Analogs

Among the analogues that can be prescribed to children are:

Before using analogues, consult your doctor.

Storage conditions and shelf life

It is recommended to store the packaging containing the medication in a corner where children cannot reach it. You need to select a dry place, the temperature in it should not be higher than 25 0 C. For 7 - 10 days, you can store the finished suspension at a temperature of 2 - 8 degrees. A solution intended for intravenous administration should be used immediately after preparation.

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One comment

I want to be a little indignant about the instructions for Augmentin, it feels like it was written only for doctors and mathematicians to calculate the required doses. The doctor prescribed it for my child after a full 5 days of fever, and it reached 39 and above already on the 5th day. It turns out that the child did not recover, but became more ill! Although we took all the medications previously prescribed by the doctor for a viral infection accurately. Now I’m wondering whether to cancel the antiviral if the doctor prescribed an antibiotic? Please advise

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Augmentin for children - when and how can you take the medicine?

The antibacterial drug Augmentin for children is used in the treatment of various diseases. The antibiotic copes well with a wide range of pathogens. However, like any drug, it has contraindications for use and side effects.

What type of antibiotic is Augmentin?

The antibiotic Augmentin belongs to combination drugs of synthetic origin and antibacterial agents of the penicillin group. It contains:

  • amoxicillin trihydrate;
  • potassium clavulanate (clavulanic acid).

The drug is available in several dosage forms: powder for injection, tablets, syrup and dry substance for preparing a suspension. Children under 12 years of age are prescribed syrup or suspension. These forms are well tolerated even by children, but it is impossible to completely exclude the development of an allergic reaction. This fact must be taken into account when prescribing medicine to children (monitor the body’s reaction after the first dose).

Augmentin - indications for use in children

The drug must be used in strict accordance with medical prescriptions. The pediatrician indicates the dosage and frequency of administration of the drug Augmentin, the indications for use of which are as follows:

  • infectious processes of the upper respiratory tract, including diseases of the ear, nose and throat (sinusitis, tonsillitis, otitis media);
  • severe inflammatory processes in the organs of the respiratory system - lobar pneumonia, bronchopneumonia;
  • diseases of the urinary system – urethritis, pyelonephritis, cystitis;
  • infections of the skin and soft tissues;
  • infectious processes in bone tissue.

Augmentin - contraindications for use

The drug is well tolerated by children, but it cannot always be used. Doctors take this feature into account when prescribing Augmentin to children, the contraindications for use of which are as follows:

  • hypersensitivity to the components of the drug;
  • intolerance to penicillin antibiotics;
  • the presence of episodes of jaundice due to previous use of a combination of amoxicillin and clavulanic acid.

It is also necessary to separately indicate contraindications for each form of medication:

  • tablets 250 mg and more are not prescribed to children under 12 years of age weighing less than 40 kg;
  • powder for preparing the suspension is contraindicated in infants under 3 months and children with phenylketonuria.

Augmentin for children, suspension – dosage

When prescribing Augmentin, the doctor explains in detail to the mother how to calculate the dose for the child. The dosage is calculated individually and depends on the type of infection, the stage of the pathological process, the age and weight of the baby. When calculating the required amount of medicine, only the content of amoxicillin sodium is taken into account - the amount of the active ingredient in a specific dosage form. For Augmentin, it is indicated on the packaging and bottle of the drug (in mg).

Augmentin 125, suspension – dosage for children

When Augmentin suspension is prescribed, the dosage for children is set taking into account the child’s body weight. This parameter is the main one when determining the dosage of antibacterial agents. It is worth noting that at the same age, children can have different weights, so prescribing drugs based on age is incorrect. Augmentin is used in this concentration for young children. The calculation of the drug is carried out as follows:

  • children under 1 year (body weight 2–5 kg) – 1.5–2.5 ml 3 times a day;
  • children 1–5 years old (6–9 kg) – 5 ml three times a day;
  • children 6–9 years old (19–28 kg) – 15 ml 3 times a day;
  • children 10–12 years old (29–39 kg) – 20 ml three times a day.

Augmentin 200, suspension – dosage for children

Augmentin 200 for children is a common dosage. At this concentration, the drug can also be prescribed to infants. A high concentration of the active substance allows you to reduce the frequency of taking the medicine. When prescribing Augmentin 200, the dosage for children is calculated as follows:

  • babies under 1 year – 1.5–2.5 ml twice a day;
  • children 1–5 years old – 5 ml of suspension 2 times a day;
  • children 6–9 years old – 15 ml 2 times a day.

Augmentin 400 – dosage for children

The maximum dosage of the drug Augmentin 400 (suspension for children) is used in the treatment of older children. This reduces the need for frequent use of the medication - it is given 2 times a day every 12 hours. When prescribing Augmentin 400 to children, doctors recommend adhering to the following dosages:

  • children 6–9 years old – 7.5 ml of suspension;
  • at 10–12 years old – 10 ml 2 times a day.

How to give Augmentin to children?

When talking about how to take Augmentin for children, pediatricians draw attention to the need for precise dosage compliance. Before use, the powder is diluted with the required amount of liquid (boiled water). For convenience, the label of the Augmentin bottle for children contains a level mark to which it needs to be filled with water. After this, screw the bottle tightly and mix the medicine thoroughly, shaking it for 2 minutes.

Take the antibiotic Augmentin for children in strict accordance with medical prescriptions. For easy dosing, use the measuring cap included in the kit or a syringe. To reduce the irritating effect of the drug on the gastric mucosa, the medicine is given to the child a few minutes before meals. After each use of the medicine, the measuring cup is thoroughly washed, dried and reused.

Augmentin - side effects in children

Suspension for children Augmentin in some cases may cause side effects when used. When they appear, stop taking the drug and report the incident to the pediatrician. If Augmentin's side effects are severe, it may be necessary to change the medication. Among such manifestations are:

  • deterioration of the gastrointestinal tract (spasms, diarrhea, nausea and vomiting);
  • disruption of the immune system - allergic reactions;
  • disruption of the circulatory system - formation of blood clots;
  • deterioration of liver function – hepatitis;
  • depression of the central nervous system - headaches, dizziness, convulsions;
  • Skin disorders – erythema, itching.

What can replace Augmentin for a child?

If the drug Augmentin is poorly tolerated for children, and a reaction develops on the part of the small organism to taking it, mothers often think about what can replace Augmentin. There are a large number of analogues on the pharmaceutical market, so choosing the right drug for your child will be easy. In this case, it is necessary to adhere to the recommendations received from the pediatrician who performed the treatment:

  1. Read the instructions.
  2. Consider the child's age.
  3. Follow the indicated dosages and frequency of taking the medication.
  4. If there are any changes in the baby’s well-being, inform the doctor.

Among drugs containing amoxicillin used to treat children, the following are most often prescribed:

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Suspension "Augmentin" for children: instructions for use

When choosing an antibiotic to treat any infection, preference is often given to drugs with a broad spectrum of antimicrobial action. One of them is Augmentin. For children, it is more convenient to give this medicine in liquid form. When is it prescribed to young children and how is the suspension prepared? Is the drug taken before or after meals? How long to treat a child? These and other questions interest every mother if her son or daughter has to take an antibiotic.

Release form

Augmentin, from which the suspension is prepared, is presented as a powder placed in a glass bottle. This powder has a white color and a characteristic odor, and after adding water it produces a white suspension, which separates during storage to form a white precipitate. The medicine is also available in injection form (it is intended for intravenous administration) and in coated tablets with different dosages (they can contain 250, 500 or 875 mg of antibiotic each).

Compound

Augmentin includes two active ingredients at once, thanks to which it has a wide range of effects on microorganisms:

  1. Amoxicillin. This antibiotic is presented in trihydrate form and is contained in 5 ml of the finished medicine at a dosage of 125 mg, 200 mg or 400 mg.
  2. Clavulanic acid. This compound is a potassium salt and the dosage of this acid is, depending on the dose of amoxicillin, 31.25 mg, 28.5 mg or 57 mg per 5 ml of suspension.

The ratio of these two components is represented by the proportion 4:1 and 7:1. Additionally, the bottle contains silicon dioxide, xanthan gum, hypromellose and succinic acid. For sweetness, aspartame is added to the preparation, and the smell of the suspension is provided by orange, raspberry and molasses flavors.

Operating principle

Amoxicillin in Augmentin has an antimicrobial effect on many types of microorganisms. It acts bactericidal, causing the death of bacteria due to inhibition of the synthesis of their cell walls. However, this antibiotic can be destroyed by beta-lactamases, so it cannot kill bacteria that produce such enzymes.

It is to prevent this destruction that clavulanic acid is present in the drug. It inactivates beta-lactamases, which makes even amoxicillin-resistant microbes sensitive to the suspension.

The drug is effective against:

  • Various types of staphylococci, including saprophytic and aureus.
  • Whooping cough sticks.
  • Various types of streptococci, including hemolytic, pyogenic and group B.
  • Nocardium.
  • Listeria.
  • Haemophilus influenzae.
  • Enterococci.
  • Helicobacter pylori.
  • Gonococcus.
  • Cholera vibrios.
  • Pasteurell.
  • Peptococci and peptostreptococci.
  • Moraxell.
  • Treponema pallidum.
  • Leptospira.
  • Borrelia.
  • Bacteroides.
  • Clostridium.
  • Fusobacterium.

The suspension may be powerless against E. coli, Proteus, Salmonella, Corynebacteria, Pneumococcus, Klebsiella and Shigella, so if infected with these microorganisms, it is recommended to first do a sensitivity test.

The drug is considered ineffective against infection with Citrobacter, Enterobacter, Morganella, Providence, Legionella, Hafnia, Pseudomonas, Yersinia, Chlamydia, Coxiella, Mycoplasma and Serracia. In addition, this medicine does not help with influenza, herpetic sore throat, ARVI, mononucleosis, chickenpox and other viral infections.

Indications

Augmentin in the form of a suspension is prescribed:

  • When bacteria damage the ENT organs and upper respiratory system, for example, with otitis media, sinusitis or recurrent tonsillitis.
  • For whooping cough or scarlet fever.
  • For exacerbation of chronic bronchitis, acute bronchitis, lobar pneumonia and other bacterial lesions of the lower respiratory tract.
  • For genitourinary infections, for example, urethritis or pyelonephritis.
  • For gonorrhea.
  • When infected with streptococci or Staphylococcus aureus of soft tissues or skin.
  • For bacterial infections of joints or bones.

At what age is it allowed to take it?

Augmentin is prescribed by pediatricians to children of any age, even infants. At the same time, suspensions with a dosage of amoxicillin of 200 mg or 400 mg per five milliliters do not give babies the first three months of life. Such medications are prescribed in children only from 3 months.

Contraindications

The drug should not be given to a child with hypersensitivity to any component of the suspension, or if allergic to other penicillin antibiotics or cephalosporins. Treatment is also prohibited for phenylketonuria, which is due to the presence of aspartame in the composition.

The medicine is prescribed very carefully to children who have impaired kidney function or liver disease. If infectious mononucleosis is suspected in a baby, the use of Augmentin may cause a measles-like rash.

Side effects

As a result of treatment with Augmentin, a child may develop:

  • Allergies in the form of itching, hives or rash.
  • Loose stools, as well as vomiting or nausea.
  • Worsening of the general blood test - a decrease in the level of platelets and leukocytes, sometimes agranulocytosis and anemia, as well as changes in the parameters of the coagulation system.
  • Candidiasis infection affecting mucous membranes or skin.
  • Increased activity of liver enzymes.
  • Headache or dizziness.

Very rare side effects of taking the suspension include Quincke's edema, anaphylaxis, nervous excitement, convulsions, inflammation of the intestines, stomatitis, discoloration of tooth enamel, nephritis and other negative phenomena. If they occur, stop treatment and immediately consult a doctor.

Instructions for use

To prepare the suspension, boiled and cooled to room temperature water in a certain amount is added to Augmentin powder. In a drug containing amoxicillin at a dose of 125 mg per 5 milliliters, you must first add 60 ml of water. Next, the medicine is shaken and left for 5 minutes, after which more water is added so that its total volume is approximately 92 ml.

If a suspension containing 200 or 400 mg of amoxicillin in five milliliters is used in treatment, then the powder is first mixed with 40 ml of water, and after five minutes a little more water is added to the bottle so that the total amount is approximately 64 ml.

In addition, treatment with the liquid form of Augmentin includes the following nuances:

  • Before each use, the medicine should be shaken so that the separated syrup becomes homogeneous.
  • The measuring cap that comes with the antibiotic bottle helps measure the exact dose of the medication. When the child has drunk the suspension, this cap is thoroughly washed with water.
  • For a child under two years of age, a single dosage of the drug can be further diluted with water 1:1.
  • The regimen of use and the calculation of a single dosage of the medicine are influenced by the child’s age and weight, as well as the condition of the kidneys and the severity of the infection.
  • To ensure that the active substances of the medication are optimally absorbed and the risk of side effects is reduced, it is recommended to take the medicine at the beginning of a meal. The suspension is given to infants during feeding.
  • How many days to take the drug is determined individually in each case, but the minimum course of treatment is considered to be 5 days. In addition, it is not advisable to give the suspension for longer than 14 days.
  • To prevent staining of your teeth, it is recommended that you brush them thoroughly several times a day.

Dosage

Babies in the first three months of life are given only a suspension, the active substances of which are presented in a 4:1 ratio (125 mg/31.25 mg).

To calculate the daily dose of medication, you need to know the baby's weight in kilograms. It is multiplied by 30 and the number of milligrams of amoxicillin is obtained. Dividing the resulting figure by 2, determine the single amount of ml of suspension, which is given to the child twice a day.

For a child aged 3 months to 12 years who weighs less than 40 kilograms, the suspension is dosed as follows:

  • The drug containing active compounds 125 mg/31.25 mg is given three times a day with an interval of 8 hours between doses.
  • A medicine containing active ingredients in an amount of 200 mg/28.5 mg or 400 mg/57 mg is prescribed twice a day, that is, such suspensions are taken twice a day.

If a child has an infection of soft tissues or skin, then Augmentin is prescribed in a low dose. It is represented by 20 mg per 1 kg of the baby’s weight per day for a suspension of 125 mg/31.25 mg/5 ml or 25 mg per day per kilogram of the child’s weight for suspensions with a proportion of active ingredients of 7:1. The same dosage is used for relapses of tonsillitis.

If Augmentin is used to treat otitis media, sinusitis, infections of the joints, genitourinary organs, lower respiratory tract or bones, high doses are used. This is 40 mg per 1 kilogram of the child’s body weight per day for a 4:1 suspension. If the baby is given the drug 7:1, then the dosage will be 45 mg per day per 1 kg of the patient’s weight. All calculations are performed using amoxicillin.

Children over 12 years of age and children weighing more than 40 kg are given 11 ml of a suspension containing 400 mg of amoxicillin and 57 mg of clavulanic acid. The drug is prescribed twice. It should be noted that for such patients it is more preferable to use the medicine in tablet form.

Overdose

If you exceed the dose of suspension prescribed by the doctor, this may disrupt the functioning of the child’s digestive system and affect the water and electrolyte balance in his body. It is also possible for crystals to form in the urine, which can cause an overdose to cause kidney failure. If the child has diseased kidneys, then exceeding the dose can cause seizures.

Interaction with other drugs

  • Combined use with antacids, laxatives or glucosamine impairs the absorption of amoxicillin.
  • When prescribed simultaneously with macrolides (for example, with Sumamed or Azitrox suspension), the effect of Augmentin will be weaker. The same effect is observed when combined with tetracyclines, sulfonamides, lincosamides and chloramphenicol.
  • The suspension can be used together with nitrofurans, for example, the drug Enterofuril.
  • Augmentin should not be given to a child together with allopurinol, as this combination can cause skin allergies.
  • When prescribed with anticoagulants (indirect), the effectiveness of these drugs will increase.
  • The drug is not prescribed together with methotrexate, since penicillins increase its toxicity.

Terms of sale

To buy powder at a pharmacy, you first need to get a prescription from a doctor. The price of one bottle depends on the dosage and can vary from 130 to 250 rubles.

Storage Features

An unopened bottle of powder can be stored until the end of its shelf life, which is 2 years, in a dry place away from children, where the temperature does not rise above +25 degrees. The drug diluted with water should be placed in the refrigerator, but the solution should not be allowed to freeze. The shelf life of liquid medicine is 7 days.

Reviews

Most of the parent reviews about Augmentin suspension are positive. Mothers note that this antibiotic helps cope with many infections and is well tolerated by most children. They confirm that the treatment begins to work quickly when there is a high fever, cough and other symptoms of infection. Within a few days from the start of treatment, the child’s condition improves.

Negative reviews complain about side effects of the drug, such as nausea or diarrhea. Pediatricians, including Komarovsky, speak mostly well of this antibacterial agent, but they emphasize that only a doctor should prescribe such a suspension to a child.

Analogs

You can replace liquid Augmentin with other drugs containing the combination of amoxicillin + clavulanic acid. Amoxiclav, Medoclav, Panclave 2X, Ecoclave, Augmentin EC are produced in the form of a suspension, and Amoxiclav Quiktab and Flemoklav Solutab are produced in the form of soluble tablets.

The doctor may also prescribe drugs based on amoxicillin to the child (Amosin suspension, Flemoxin Solutab tablets or Hiconcil suspension) or drugs in the form of a suspension from the cephalosporin group (Suprax, Pancef, Zinnat and others).

At the same time, only a pediatrician can decide what is best suited as a substitute for Augmentin. A good specialist will take into account the clinical picture and antibiotic sensitivity tests, and then prescribe the correct treatment.

In the following video, the popular children's doctor Komarovsky talks in detail about antibiotics, why they are needed and in what cases they are used.

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Source: http://www.o-krohe.ru/antibiotiki/suspenziya-augmentin/

Augmentin

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Augmentin instructions for use

Clinical pharmacology

Release form and composition

●Tablets po 625 mg, No. 14. Amoxicillin 500 mg, clavulanic acid 125 mg Other ingredients: anhydrous colloidal silicon dioxide, sodium starch glycolate, magnesium stearate, microcrystalline cellulose, titanium dioxide, hypromellose (5cps), hypromellose (15cps), macrogol 4000, macrogol 6000, dimethicone 500 (silicone oil). The drug contains amoxicillin in the form of trihydrate and clavulanic acid in the form of potassium salt.

●Tablets po 875 mg + 125 mg, No. 14. Amoxicillin 875 mg Clavulanic acid 125 mg The drug contains amoxicillin in the form of trihydrate and clavulanic acid in the form of potassium salt.

●Powder d/p in. solution 0.6 g vial, No. 10. Amoxicillin 500 mg Clavulanic acid 100 mg

●Powder d/p in. solution 1.2 g fl., No. 5, No. 10. Amoxicillin 1000 mg Clavulanic acid 200 mg The drug contains amoxicillin in the form of trihydrate and clavulanic acid in the form of potassium salt.

●Powder d/p susp. 228.5 mg/5 ml vial. 70 ml, No. 1. Amoxicillin 200 mg/5 ml Clavulanic acid 28.5 mg/5 ml Other ingredients: xanthan gum, hydroxypropyl methylcellulose, colloidal anhydrous silicon dioxide, succinic acid, silicon dioxide, dry orange flavorings (610271E and 9/027108) , dry raspberry flavoring, dry flavoring “Light molasses”, aspartame (E951). The drug contains amoxicillin in the form of trihydrate and clavulanic acid in the form of potassium salt.

●Powder d/p susp. 600 mg/5 ml + 42.9 mg/5 ml vial. 100 ml. Amoxicillin 600 mg/5 ml Clavulanic acid 42.9 mg/5 ml Other ingredients: anhydrous colloidal silicon, sodium carboxymethylcellulose, aspartame, xanthan gum, silicon dioxide, strawberry flavor. The drug contains amoxicillin in the form of trihydrate and clavulanic acid in the form of potassium salt.

Interaction

Concomitant use of allopurinol during treatment with amoxicillin increases the likelihood of developing skin allergic reactions. There are no data regarding the combined use of Augmentin and allopurinol.

Like other antibiotics, Augmentin can affect the intestinal flora, which leads to a decrease in estrogen reabsorption and a decrease in the effectiveness of combined oral contraceptives. The presence of clavulanic acid in Augmentin can cause nonspecific binding of IgG and albumin on red blood cell membranes, as a result of which the Coombs test may be false positive.

Augmentin in solution for injection should not be mixed with blood products, other liquids containing protein, in particular, with protein hydrolysates, with fat emulsions for intravenous use.

If Augmentin is used simultaneously with aminoglycosides, antibiotics should not be mixed in the same syringe or other container due to inactivation of the aminoglycoside.

It is prohibited to drink alcohol during treatment with Augmentin.

Overdose

How to take, course of administration and dosage

● Augmentin (ВD) tablets 625 mg (500/125 mg) For the treatment of mild and moderate infections in adults and children over 12 years of age: 1 tablet of Augmentin (ВD) 2 times a day. For severe infections (including chronic and recurrent urinary tract infections and bronchopulmonary infections), 1-2 tablets of Augmentin (BD) are prescribed 3 times a day. The recommended dosage for dentoalveolar abscesses is 1 tablet 2 times a day for 5 days.

Dosing for renal impairment.

Mild failure (creatinine clearance >30 ml/min) No dosing changes (i.e. 1 tablet twice daily) Moderate failure (creatinine clearance 10–30 ml/min) 1 tablet twice daily Severe renal failure ( creatinine clearance 14 days without assessing the patient's condition. Treatment can be started parenterally, then continued orally. Augmentin tablets 1 g (875/125 mg) Dosage depends on the patient's age and body weight, renal function, severity of infection. Dose for the treatment of mild and moderate severity in adults and children over 12 years of age: 1 tablet of Augmentin 875/125 mg 2 times a day. For severe infections (including chronic and recurrent urinary tract infections and bronchopulmonary infections) - 1 tablet of Augmentin 3 times a day. Augmentin 1 g tablets are not recommended for use in children under 12 years of age.

Dosing for renal impairment: Augmentin tablets 1 g (875/125 mg) are used only in patients with creatinine clearance >30 ml/min. In case of renal failure with creatinine clearance of 30 ml/min, there is no need to change the dose. For the treatment of children with GFR, 1 hour - as indicated above, and up to 4 doses of 1000/200 mg of the drug are administered according to the instructions over 24 hours. The purpose of using Augmentin during surgical interventions is to reduce the risk of developing a postoperative infectious complication. In case of clinical signs of infection during surgery, it is necessary to carry out a full course of intravenous or oral use of Augmentin after surgery. Renal dysfunction. Dose adjustments are based on the maximum recommended doses of amoxicillin. Creatinine clearance 4 kg - up to 25/5 mg/kg every 8 hours, depending on the course of the infection.

●Children aged 3 months to 12 years: 25/5 mg/kg every 6–8 hours, depending on the course of the infection.

●Preparation of the solution 600 mg bottle: dissolve the contents in 10 ml of water for injection (final volume 10.5 ml). 1.2 g bottle: dissolve contents in 20 ml water for injection (final volume 20.9 ml). During dissolution, a temporary pink color may or may not appear, which disappears. Augmentin solutions are usually colorless or have a pale straw color.

●IV injection. The stability of Augmentin solution is concentration dependent, so Augmentin solution should be used immediately after dissolution and administered slowly over 3-4 minutes. Augmentin can be injected directly into a vein or through a catheter as a drip.

●IV infusion. Augmentin can be administered intravenously as an infusion, dissolved in water for injection or in 0.9% sodium chloride solution for injection. Add 600 mg solution to 50 ml of infusion fluid or 1.2 g solution to 100 ml of infusion fluid (it is better to use a mini-container or burette). Carry out the infusion over 30–40 minutes within a 4-hour period after dissolution. The solutions are brought to full volume, which is introduced immediately after the powder is dissolved. The remaining antibiotic solutions cannot be used. When warmed to room temperature, the solution should be used immediately. Augmentin is less stable in solutions of glucose, dextran and bicarbonate. Solutions on this basis must be used within 3–4 minutes after dissolution. Any unused solution should be destroyed. Augmentin is not designed for multi-dose use.

●Augmentin ES. Children aged 3 months and older: the recommended dose is 90/6.4 mg/kg/day in 2 divided doses at 12-hour intervals for 10 days (see table below). There is no experience of use for the treatment of children weighing >40 kg and adults. There is also no experience of clinical use for the treatment of children under 3 months of age. Augmentin ES does not contain the same amount of clavulanic acid (as the potassium salt) as other forms of Augmentin suspension. Augmentin ES contains 42.9 mg clavulanic acid per 5 ml suspension, while Augmentin 200 mg/5 ml suspension contains 28.5 mg clavulanic acid per 5 ml, and 400 mg/5 ml suspension contains 57 mg clavulanic acid per 5 ml. Therefore, Augmentin ES cannot be replaced by any other form of Augmentin suspension. Liver dysfunction. Use cautiously and monitor liver function at regular intervals. The available data are insufficient to make dosage recommendations. Renal dysfunction. There are no recommendations regarding the use of the drug for the treatment of this group of patients. In order to minimize the risk of undesirable effects of Augmentin ES on the gastrointestinal tract, the drug is taken at the beginning of a meal, while the absorption of Augmentin ES is optimal. Treatment can be started with parenteral administration of the drug, and continued with an oral form of the drug.

Contraindications

special instructions

Serious and sometimes fatal hypersensitivity reactions (anaphylactic reactions) to penicillins have been described. The risk of such reactions is highest in patients with a history of hypersensitivity reactions to penicillins. If an allergic reaction occurs, treatment with Augmentin® should be discontinued and appropriate alternative therapy should be initiated. For severe hypersensitivity reactions, epinephrine should be administered immediately. Oxygen therapy, intravenous administration of corticosteroids, and airway management, including intubation, may also be required.

It is not recommended to prescribe Augmentin® if infectious mononucleosis is suspected, since amoxicillin can cause a measles-like rash in patients with this disease, which makes diagnosing the disease difficult.

Long-term treatment with Augmentin® sometimes leads to excessive proliferation of insensitive microorganisms.

In general, Augmentin® is well tolerated and has the low toxicity characteristic of all penicillins.

During long-term therapy with Augmentin®, it is recommended to periodically evaluate renal, liver and hematopoietic function.

In order to reduce the risk of developing side effects from the gastrointestinal tract, the drug should be taken at the beginning of a meal.

In patients receiving a combination of amoxicillin and clavulanic acid together with indirect (oral) anticoagulants, an increase in prothrombin time (increase in MHO) has been reported in rare cases. When co-prescribing indirect (oral) anticoagulants with a combination of amoxicillin and clavulanic acid, monitoring of relevant indicators is necessary. Dosage adjustments may be required to maintain the desired effect of oral anticoagulants.

In patients with impaired renal function, the dose of Augmentin® should be reduced according to the degree of impairment.

In patients with reduced diuresis, the development of crystalluria has been reported in very rare cases, mainly with parenteral use of the drug. During administration of high doses of amoxicillin, it is recommended to take sufficient fluids and maintain adequate diuresis to reduce the likelihood of amoxicillin crystal formation.

Taking Augmentin® orally leads to a high level of amoxicillin in the urine, which can lead to false-positive results when determining glucose in the urine (for example, Benedict's test, Fehling's test). In this case, it is recommended to use the glucose oxidant method for determining the concentration of glucose in urine.

Oral care helps prevent tooth discoloration by simply brushing your teeth.

The tablets must be used within 30 days of opening the laminated aluminum foil package.

Drug abuse and dependence

There was no drug dependence, addiction, or euphoric reactions associated with the use of Augmentin®.

Impact on the ability to drive vehicles and operate machinery

Since the drug may cause dizziness, patients should be warned to take precautions when driving or operating moving machinery.

Augmentin indications for use

●infections of the upper respiratory tract (including infections of the ENT organs), including recurrent tonsillitis, sinusitis, otitis media;

●lower respiratory tract infections, including chronic bronchitis in the acute phase, lobar pneumonia and bronchopneumonia;

●infections of the urinary system, including cystitis, urethritis, pyelonephritis;

●infections of the skin and soft tissues, including burns, abscesses, inflammation of the subcutaneous tissue, wound infections, animal bites;

●infections of bones and joints, including osteomyelitis;

●other infections, including septic abortion, postpartum sepsis, intra-abdominal sepsis;

●dental infections, including dentoalveolar abscesses.

The use of Augmentin tablets 1 g (875/125 mg) is also indicated for infections of the female genital organs and gonorrhea. Infections caused by amoxicillin-sensitive microorganisms are effectively treated with Augmentin, given the amoxicillin content in it. Mixed infections caused by amoxicillin-insensitive microorganisms in combination with augmentin-sensitive microorganisms that produce beta-lactamase can thus be treated with Augmentin. Augmentin ES: treatment of bacterial infections in children caused by microorganisms sensitive to Augmentin: infections of the upper respiratory tract (including ENT organs), including recurrent or persistent otitis media (children's patients, as a rule, who have received antibiotic therapy for otitis media for at least 3 months or under 2 years of age or attending preschool institutions); tonsillopharyngitis or sinusitis; lower respiratory tract infections, including lobar and bronchopneumonia; skin and soft tissue infections.

Storage conditions

On prescription

Manufacturer

Augmentin Photos

Certificates Augmentin

Augmentin delivery and pickup in Moscow and the region

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  • Augmentin, GlaxoSmithKline

License: No. LO814 dated August 8, 2016, OGRN: 1988

Source: http://www.eapteka.ru/goods/drugs/antibacterial/antibiotic/augmentin_glaksosmitklyayn/

Antibiotic Augmentin for children

Augmentin is a unique product that includes potent ingredients: amoxicillin 250, 500, 875 mg and clavulanic acid 125 mg (similar in composition to penicillin). The antibiotic Augmentin has a wide spectrum of action. The active ingredient amoxicillin is easily tolerated by the body, side effects are rare, so the drug is safe for small children. Augmentin is allowed to be used by women during pregnancy (as prescribed by the attending physician) and infants.

For drug labeling, it is customary to use the abbreviated names Augmentin 400, 600 with the obligatory clarification of the dosage.

Indications for use

The antibiotic Augmentin is produced in several forms:

  • Dragee (contains 125 mg of clasulanic acid, 875 g of amoxicillin);
  • Powder for injection;
  • Powder for oral use.

During the course of treatment, it is possible to change the medicinal type of the product (instead of injections, tablets are prescribed). All forms of Augmentin are intended for the treatment of bacterial infections that provoke the following diseases in children:

  • Respiratory tract infections: sore throat, sinusitis, tonsillitis, bronchitis, pneumonia;
  • Urinary tract disease (urethritis, cystitis);
  • Periodontitis, severe types of dental abscesses;
  • Various infections (puerperal sepsis, infections caused by surgical interventions, peritonitis, cholecystitis, ear inflammation);
  • Infections of soft tissues of the skin, bone mass, joints (abscesses, abscess).

Augmentin is considered an excellent treatment for bacterial infection of the tonsils, i.e. tonsillitis. When treating angina, the drug is taken in a dosage of 875 mg once a day or 500 mg 3 times a day. The duration of treatment for sore throat is 7-8 days. Also, for sore throat, the doctor may prescribe an analogue of the drug.

How to use the drug

Instructions for use recommend taking the drug or an analogue before meals to reduce the risk of digestive tract disorders. Duration of therapy is no more than 2 weeks, but not less than 5 days. The dosage of Augmentin is determined individually, based on the patient’s age category, weight and complexity of the disease. The use of the medicine was divided into age categories in order to conveniently calculate the dose for children.

Adults and children over 12 years old (weight category not exceeding 40 kg):

  • 1 tablet 250 mg or 125 mg 3 times a day;
  • 10 ml of ready-made suspension (syrup) 400 mg/57 mg/5 ml 2 times a day;
  • 2 tablets of 250 mg/125 mg are not equal to 1 tablet of 500 mg/125 mg.

Taking the antibiotic Augmentin tablets is not recommended for children under 12 years of age.

In case of severe infection, the use of the antibiotic Augmentin or its analogues is prescribed according to the dosage:

  • 3 times a day tablets at a dosage of 250/125 mg (2 doses);
  • 3 times a day tablets at a dosage of 875/125 mg.

In adults and children undergoing hemodialysis, use the drug (analogue) according to the instructions:

  • 1 tab. 500 mg + 125 mg in one dose every 24 hours;
  • or 2 tab. 250 mg/125 mg in one dose every 24 hours;
  • or 500 mg/125 mg (20 ml of suspension at a dose of 125 mg/31.25 mg in 5 ml) 1 time/day.
In the first 3 months and less than 12 years (weight category up to 45 kg), a suspension (syrup) is prescribed for children as a convenient use; the child’s weight is taken into account when calculating the correct dosage:
  • Taking a suspension at a dosage of 125 mg/31.25 mg in 5 ml – 3 times a day every 8 hours;
  • At a dosage of 200 mg/28.5 mg in 5 ml or 400 mg/57 mg in 5 ml – 2 times a day every 12 hours.

Small doses of the drug are used to treat skin infections, and larger doses are prescribed to treat infections of the upper and lower respiratory tract.

Infants and children up to 3 months inclusive are recommended to take a dosage of 30 mg/kg 2 times a day. If a suspension is chosen for the course of treatment, it must be diluted in a ratio of 4:1. The use of Augmentin suspension is calculated in a ratio of 7:1 (200 mg/28.5 mg in 5 ml or 400, 600 mg/57 mg in 5 ml).

The use of Augmentin by patients with liver dysfunction is carried out under the strict supervision of the attending physician, with mandatory monitoring of changes in well-being. Unfortunately, there are no clear dosage calculation data for this category of patients.

According to the instructions, the drug is stored in a dry place, out of reach of children, at an average temperature of no more than 25 degrees. Shelf life: 2 years (see manufacturing date on packaging).

How to prepare a suspension

To prepare a suspension at a dosage of 125 mg/31.25 mg in 5 ml, dissolve the powder in boiled water, cooled to room temperature, close the bottle and shake well. The powder should completely dissolve. Leave the bottle for a few minutes, add water to the indicated mark and shake again. Each time you use the suspension, the bottle must be shaken. Store the drug in a cool place for no more than 7 days from the date of preparation.

If the suspension is to be used by a child under 2 years of age, you can dilute the drug using twice as much water.

The dosage (200, 250 mg/28.5 mg in 5 ml or 400, 600 mg/57 mg in 5 ml) is prepared in the same way, the method of storing the finished suspension is identical. For a child under 2 years old, prepare a measured single dose in a 1:1 ratio. Store the prepared suspension in a cool place for 7 days after its preparation.

Contraindications and side effects

The instructions specify contraindications for the use of the drug:

  • Jaundice or liver dysfunction that appeared during use;
  • Severe susceptibility to betalactam antibiotics.

The drug is not compatible with blood products containing protein; it is forbidden to mix the drug with a dropper with aminoglycoside antibiotics, because inactivation occurs.

If a child is prone to allergies, has had allergic reactions to antibiotics, or has impaired liver function when taking similar medications, taking Augmentin is not recommended. Children with allergies should be treated with antibacterial drugs very carefully so as not to provoke urticaria, Quincke's edema and other reactions. It is strictly forbidden to take the drug during pregnancy (first trimester).

Like any antibacterial drug, Augmentin can cause characteristic side reactions:

  • Nausea, vomiting, headaches, dizziness;
  • Liver dysfunction, formation of hepatitis, jaundice, bile stagnation;
  • Possible colitis, intestinal colic with attacks of severe abdominal pain and excretion of feces with a large amount of mucus;
  • Significant increase in body temperature, insomnia, agitation, anxiety, stomatitis, gastritis;
  • Increased amount of bilirubin in the body.
It is extremely rare that the drug can cause anaphylactic shock, exfoliative dermatitis, and angioedema. In rare cases, when the drug is administered intravenously, phlebitis may occur, i.e. inflammation of the vein at the injection site.

Analogs

There are a number of Augmentin analogs with similar pharmacological properties:

  • Amoxiclav - prescribed for the treatment of bacterial infections of the ear, nose, throat, diseases of the urinary tract, and purulent lesions of soft tissues;
  • Sulbacin - effective for diseases of the ENT organs, respiratory organs, genitourinary system, infections of the skin and bones;
  • Flemoxin is a drug for the treatment of inflammatory processes occurring in the gastrointestinal tract, respiratory and genitourinary systems;
  • Flemoklav - used to treat respiratory infections caused by bacteria, soft tissue abscesses, inflammation of the urinary tract;
  • Sumamed - suitable for the treatment of infections of the ENT organs, stomach and intestines, diseases of soft tissues and bones.

Before using the Augmentin analogue and its analogues, carefully read the instructions for use of the antibiotic and check the dosage.

Source: http://lecheniedetej.ru/preparaty/antibiotiki/augmentin.html