Salbutamol analogue aerosol

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Salbutamol

Description current as of 01/16/2015

  • Latin name: Salbutamol
  • ATX code: R03AC02
  • Active ingredient: Salbutamol (Salbutamol)
  • Manufacturer: OJSC “Moskhimfarmpreparaty im. ON THE. Semashko”, CJSC “Binnopharm”, CJSC “Altaivitamins” (Russian Federation), TEVA (Israel)

Compound

One dose of metered dose inhalation aerosol contains 124 mg of salbutamol sulfate, which corresponds to 100 mcg of pure substance.

Table of contents:

Ethanol and hydrofluoroalkane are used as excipients.

One tablet may contain 2 or 4 mg of the active substance, prolonged-release tablets (retard) - 4 mg (for children) and 8 mg (for adults).

One dose of powder for inhalation contains 200 or 400 mcg of salbutamol, syrup for oral use - 0.4 mg/ml, solution for inhalation - 1.25 mg/ml (the solution is supplied to pharmacies in 2 ml ampoules, according to 20 ampoules in one package), in injection solution - 0.1 mg/ml.

Release form

Salbutamol (INN - Salbutamol) has the following dosage forms:

  • metered-dose aerosol for inhalation 100 mg/dose (available in aluminum cans under pressure, 200 doses in each inhaler; when sprayed onto a glass surface, the contents of the can leaves a white spot);
  • dosed powder for inhalation 200 or 400 mg/dose;
  • film-coated tablets of 2 and 4 mg.

Salbutamol preparations sold under other brand names may also take the form:

  • retard tablets;
  • solution for inhalation;
  • injection solution;
  • syrup;
  • concentrate for preparing an infusion solution;
  • capsules filled with powder for inhalation use.

pharmachologic effect

Salbutamol is a bronchodilator, a selective β2-adrenergic agonist (selective β2-adrenergic receptor antagonist). Pharmacological action of the drug: tocolytic and bronchodilator.

Pharmacodynamics and pharmacokinetics

When used in a therapeutic dose, it has a pronounced bronchodilator effect, prevents and relieves bronchospastic syndrome, increases the vital capacity of the lungs, and impedes the release of histamine, chemotaxis factors, slow-reacting substances and a number of other highly active substances into the extracellular space.

With the use of salbutamol, slight positive ino- and chronotropic effects on the heart muscle are noted.

The drug helps to dilate the coronary arteries of the heart, suppress early and late bronchial reactivity, reduce resistance in the respiratory tract, as well as the tone and contractile activity of the myometrium, improve the function of the ciliated epithelium of the bronchi, stimulate the discharge of sputum and mucus production.

At the same time, the drug has practically no effect on β1-adrenergic receptors, does not provoke a decrease in blood pressure and, in comparison with other drugs that have a similar mechanism of action, has a much lesser effect on the heart.

Salbutamol also has metabolic effects: it helps reduce the concentration of potassium in the blood plasma, affects the process of breakdown of glycogen into glucose (glycogenolysis) and insulin secretion.

In some patients (especially in patients with bronchial asthma) it can have hyperglycemic and lipolytic effects, thereby increasing the risk of developing lactic acidotic coma.

After administration of inhaled forms of the drug, the effect begins to develop after 5 minutes and reaches a maximum within minutes (about 75% of the maximum effect is achieved within 5 minutes).

From 10 to 20% of the dose received by the patient enters the respiratory tract, the remaining 80-90% remains in the device and settles in the oropharynx, after which it is swallowed. The substance remaining in the respiratory tract is partially absorbed in the lungs and, without being biotransformed in them, enters the bloodstream.

Part of the substance entering the gastrointestinal tract is absorbed and actively metabolized during the first passage through the liver with the formation of phenolic sulfate.

Both the conjugate and the unchanged substance are excreted primarily in the urine.

Most of salbutamol injected into a vein, taken orally or inhaled is eliminated from the body within 72 hours. The half-life is from 3.7 to 5 hours.

Indications for use

Indications for the use of Salbutamol are:

  • bronchospasm observed in all forms of bronchial asthma (the drug can be used both to relieve bronchospastic syndrome and to prevent it);
  • emphysema;
  • Chronical bronchitis;
  • asthmatic bronchitis;
  • uncomplicated premature birth.

In pediatrics, Salbutamol is also used to treat broncho-obstructive syndrome.

Contraindications

The use of Salbutamol is contraindicated in:

The drug is not prescribed in combination with non-selective β-blockers, or for the treatment of children under 2 years of age.

It should be used with caution in hyperthyroidism, pheochromocytoma, severe chronic heart failure, and arterial hypertension.

Intravenous use of Salbutamol is contraindicated in:

  • intrauterine fetal death;
  • birth canal infections;
  • bleeding associated with placenta previa;
  • premature placental abruption;
  • threatened spontaneous abortion in the 1st or 2nd trimester of pregnancy;
  • late toxicosis (toxicosis of the 3rd trimester of pregnancy).

Side effects

Salbutamol, produced in the form of an aerosol, does not cause side effects when used in therapeutic doses.

Oral use, subject to the dosage regimen described in the instructions, is rarely accompanied by unwanted side effects.

When a single or daily dose of Salbutamol is exceeded, as well as in patients with hypersensitivity to β2-adrenergic receptor stimulants, the most significant side effects may be tremor of the fingers or hands, internal tremors, and increased tension.

If the therapeutic dose is significantly exceeded or the patient is particularly sensitive, transient dilatation of peripheral vessels, dizziness, headache, moderate tachycardia, nausea, muscle cramps, and vomiting may occur.

Instructions for use of Salbutamol

For patients over 12 years of age, the daily dose of Salbutamol in dosage forms intended for oral administration ranges from 6 to 16 mg. It is recommended to divide it into 3-4 doses. In cases where this is necessary, the daily dose may be increased to 32 mg with a frequency of applications 4 times a day.

For children from 6 to 12 years old, Salbutamol 2 mg 3 or 4 times a day is indicated; for patients from 2 to 6 years old, the optimal dose is 3 times a day.

When administered by inhalation, the dose depends on the prescribed dosage form. In accordance with the instructions for use, Salbutamol aerosol is prescribed to relieve bronchospastic syndrome or an attack of bronchial asthma. For adults, the spray is usually recommended to be administered at 0.1-0.2 mg, for children - at 0.1 mg.

The frequency of procedures depends on the clinical situation and indications.

In order to prevent an attack of bronchial asthma associated with physical stress, before physical activity, Salbutamol aerosol is administered to children in a dose of 0.1 mg, for adults - 0.2 mg. The highest daily dose is 0.8 mg (corresponds to 8 inhalations).

The medicine, available in powder form, should be used according to a similar scheme, but with a corresponding doubling of the dose.

The solution for inhalation is used in a dose of 2.5 mg 3 or 4 times a day. If appropriate, it is possible to increase the dose to 5 mg with the same frequency of applications.

Instructions for use of the Salbutamol inhaler

Before using the inhaler, you should check its functionality. This procedure is also recommended if the patient has not used it for some time.

  • It is necessary to remove the cap from the inhaler and make sure that the outlet tube is not clogged with dust or dirt.
  • While holding the can in a vertical position, place your thumb under the bottom and your index finger on its top, after which you need to vigorously shake the can up and down several times.
  • After taking a deep breath (it is recommended to inhale without straining), you should throw your head up and tightly pinch the outlet tube of the inhaler with your lips.
  • Holding the tube with your lips, you should take a slow, deep breath, while simultaneously pressing your index finger (in the first third of your inhalation) on the valve of the inhaler can and releasing a dose of medication. The air continues to be inhaled slowly.
  • Having removed the canister tube from your mouth, you need to hold your breath for 10 seconds (or as long as possible without straining), and then slowly exhale through your nose.
  • If you need to take more than one dose of Salbutamol, wait for about a minute after the first inhalation and then repeat all the steps described above (starting from the second point). After completing the procedure, the can should be closed with a cap.

When releasing a dose of medicine, you should not rush; to achieve maximum effect, you need to inhale the air as slowly as possible. It is optimal to practice a little in front of a mirror before the procedure.

If during inhalation steam comes out from the top of the inhaler or from the corners of the mouth, you must start inhalation again from the second point.

How to clean the inhaler?

The inhaler must be cleaned at least once a week. The can is removed from the plastic case, after which the case and cap are washed with warm water (not hot!).

Washed parts should be dried thoroughly without using heating devices. After this, the can is again placed in the case and closed with a cap.

Do not dip the metal can into water.

Overdose

Symptoms of an overdose of Salbutamol are:

Treatment involves discontinuation of the drug, prescribing the patient cardioselective β-blockers and symptomatic therapy.

If there is a suspicion of an overdose of Salbutamol, it is necessary to keep serum potassium concentrations under constant monitoring.

Interaction

When using Salbutamol in combination with non-cardioselective β-blockers, mutual inhibition of therapeutic effects is possible. In combination with theophylline, the risk of developing arrhythmia and tachycardia (in particular, supraventricular extrasystole) may increase.

In combination with diuretics, glucocorticosteroids and xanthine derivatives, the risk of developing hypokalemia increases.

Terms of sale

A prescription is required to purchase the drug.

Salbutamol recipe in Latin:

Rp: Aeros. Salbutamoli 12ml

S: During an attack of suffocation, take 1-2 breaths

Storage conditions

It is recommended to store Salbutamol in a place protected from direct sunlight. The temperature should not exceed 30°C. Do not freeze, keep away from children.

The aerosol can must be protected from impacts and falls.

Best before date

36 months from date of issue.

special instructions

Increasing the dose or increasing the frequency of applications should be under the supervision of a physician. Reducing the interval is allowed only in extreme cases, and it must be strictly justified.

When using the drug, there is a risk of developing hypokalemia, therefore, in patients with severe forms of bronchial asthma, it is recommended to constantly monitor serum potassium concentrations. The risk of hypokalemia increases with hypoxia.

The World Anti-Doping Agency (WADA) prohibits the use of Salbutamol in sports, since this drug has the ability to artificially increase endurance and physical activity during sports competitions.

The use of tablet forms of the drug is usually recommended when inhalation administration of the drug is impossible (for example, in young children), since exceeding the dosage in this dosage form can provoke a cardiac stimulating effect.

Salbutamol analogs

Which is better - Salbutamol or Ventolin?

Ventolin is a generic (or structural analogue) of Salbutamol. The drugs contain the same active ingredient, so they have the same indications and contraindications and are interchangeable.

Some patients have the question “Ventolin (Salbutamol) - hormonal or not?” Experts answer that the drug does not belong to the group of hormonal drugs and is a bronchodilator to relieve bronchospasm.

Where did Salbutamol Semashko go?

At special thematic forums in recent months, the question of where the Moscow salbutamol from the manufacturer Semashko disappeared has been actively discussed. In this regard, on the official website of Moskhimfarmpreparaty OJSC, an explanation from the management appeared as to why the drug produced by the company disappeared and where it went.

The thing is that this product contains chlorofluorocarbons, which pose a danger to the ozone layer. Therefore, in accordance with the Montreal Protocol on Substances that Deplete the Ozone Layer, the Russian Federation had to decide to stop its release.

Salbutamol Semashko was discontinued, which was announced at a conference on regulating the circulation of substances that deplete the ozone layer, which was held in Moscow in mid-August 2014, initiated and organized by the UN.

The management asks everyone interested in the question of where Salbutamol-Moskhimfarmpreparaty disappeared to wait out the current situation. By 2015, the company plans to release a new drug called “Salbutamol sulfate”, in which the prohibited components will be replaced with harmless ones.

In particular, the freon-11 solvent and freon-12 atomizer will be replaced with hydrofluorocarbon 134a, and it is planned to use alcohol as a solvent.

Salbutamol during pregnancy

During pregnancy, the use of Salbutamol is contraindicated. During breastfeeding, the drug can be prescribed if the benefits to the mother outweigh any possible risks to the baby. This is due to its ability to pass into breast milk.

Reviews about Salbutamol

Salbutamol is described as a strong and effective remedy. In particular, a lot of positive reviews were left about drugs produced by Russian companies Moskhimfarmpreparaty im. ON THE. Semashko and Altaivitamins.

For many people who suffer from bronchial asthma, these remedies are a real salvation, as they quickly improve the patient’s condition even with severe bronchospasm.

Another advantage of domestic drugs is their low price compared to foreign analogues, which is a very important selection criterion for a person who is forced to use the drug for a long time.

Reviews for Salbutamol-Teva look somewhat less optimistic. Almost all patients who have tried this drug note the aesthetic appearance and inconvenience of the inhaler. The main disadvantage of the device is the short mouthpiece, which makes using the medicine not very comfortable.

Salbutamol price

The price of Salbutamol aerosol depends on which company produced the drug and varies from 95 to 220 rubles. In Ukraine, the average price of a Salbutamol inhaler is 35 UAH.

Noting the high effectiveness of the drug from Moskhimfarmpreparaty OJSC and the fact that the drug has disappeared from pharmacies, many people with bronchial asthma are wondering where to buy Salbutamol Semashko in Moscow. Pharmacy staff advise looking for medicine on special forums and online pharmacies.

Sharing personal experience, many people say that you can try to buy Salbutamol Moscow in the regions. For example, one of the users wrote that he could not find the medicine in pharmacies in Moscow, but in one of the pharmacies in the suburbs it was sold in sufficient quantities.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Ukraine Ukraine
  • Online pharmacies in Kazakhstan Kazakhstan

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BIOSPHERE

Salbutamol (with freons) is not a drug, because it has no intoxicating effect, but alcohol can already be called alcohol, because there is a percentage of alcohol in it, I don’t know what drivers should do in such a situation now, because I also know that ozone-safe drugs cannot be called drugs for asthmatics. Maximum salbutamol with freons can be called doping for athletes, because it can be used to make the lungs tireless, but we are not athletes and do not participate in the Olympic Games, which we do not regret at all today.

My friend also said that he switched to Ventolin, but with additional purchases of supplements. He says the same thing, that this ventolin helps him every once in a while and that it runs out quickly, and before he used Semashko, but they changed it. He himself is a silent person, but he is a good friend and does not like publications or mitinogi, he tries to generally hide this illness, most likely he has a complex. He doesn’t go to doctors either, he says that he saw them all as a child. will be registered and this will affect work. He says that while he buys more strong painkillers, it relaxes the lungs if Ventolin alone does not cope. He doesn’t use alcohol either, that’s what the poison says. Here he is waiting.

and we still have Altai salbutamol with freon in our pharmacy. True, you get used to it in relation to Semashko, who was exchanged for alcohol, but what can you do, at least this.

I have a mild form of asthma. I used Salbutamol MHPP with refrigerant and did not need anything else. After it was discontinued, I switched to Ventolin (ozone-safe, without alcohol, without freon). I want to say that this is not a bad drug, unlike Semashko with alcohol and other drugs similar to alcohol. A distinctive feature is the absence of side effects, but there is one thing, sometimes there are attacks that cannot be relieved by Ventolin due to weather conditions, for example. We have to resort to other measures and this turns out to be Salbutamol with alcohol, which has a lot of side effects. Colds occur in small drafts, and it’s true that they can harm your health even more by causing bronchitis and pneumonia. But today I don’t see any other way out, Ventolin is not able to relax the lungs properly in a difficult situation and it’s a shame. I now have to buy two Ventolin and Salbutamol inhalers with alcohol, instead of one Semashko with freon as before. It was as if this Semashko and the freon had been sawed in half. This is the same when I go to the store to buy bread and they sell it to me only in halves at the price of a whole loaf for each half. Thus, it has become inconvenient, more expensive and ineffective due to many side effects.

Your salbutamol sulfate is the same as dried banana. Having once bought this drug, I almost went to the next world, I saved myself with an old can of inhalations in which there were 5 inhalations left. Tell me, did they start producing salbutamol with freons again using the old composition? It’s just that at the pharmacy recently on 02/02/16 I came across salbutamol “Altaivitamins” which contained freon 11 and 12, which means it was allowed? The release date was 04.15. Thanks in advance if you answer my questions.

SEVERE DRY COUGH. I RELIEVED THE COUGH WITH A VALIDOL TABLET! THROAT IS JUST LIKE SANDAY! It's sore and itchy! I'VE BEEN ON SALBULTAMOL FOR A LONG TIME, 10 YEARS. THE BEST YEARS ARE SIMASHKO'S RELEASE BEFORE 2005. A STRONG ADDICTABILITY TO THE DRUG. USE VERY CAREFULLY! YOU CAN NETWORK ON IT

Inna: Usually, insomnia occurs for me due to some kind of experience and when you lie down, it’s not.

Olesya: I tried glycine forte, which is more expensive in the price category, but the dosage is the same.

Andrey: Not a word is said about choosing the size of stockings according to a person’s parameters: height, leg size, etc.

Olga: For coxarthrosis of the 2nd degree, I have been injecting for 4 years at the rate (after 6 months), there is no improvement.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/salbutamol

Salbutamol - instructions for use, reviews, analogs and release forms (aerosol or spray for inhalation 100 mcg, tablets 2 mg and 4 mg) of the drug for the treatment of bronchial asthma in adults, children and pregnancy. Composition and side effects

In this article you can read the instructions for use of the drug Salbutamol. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Salbutamol in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Salbutamol in the presence of existing structural analogues. Use for the treatment of bronchial asthma and relief of bronchospasm in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Salbutamol is a selective beta2-adrenergic receptor antagonist. In therapeutic doses, it acts on beta2-adrenergic receptors of the smooth muscles of the bronchi, providing a pronounced bronchodilator effect, prevents and relieves bronchospasm, and increases the vital capacity of the lungs. Prevents the release of histamine, a slow-reacting substance from mast cells and neutrophil chemotaxis factors. Causes a slight positive chrono- and inotropic effect, dilates the coronary arteries and practically does not reduce blood pressure. It has a tocolytic effect: it reduces the tone and contractile activity of the myometrium.

It has a number of metabolic effects: it reduces the potassium content in plasma, affects glycogenolysis and insulin secretion, has a hyperglycemic (especially in patients with bronchial asthma) and lipolytic effect, and increases the risk of developing acidosis.

The effect of the drug begins 5 minutes after inhalation administration and lasts for 4-6 hours.

Salbutamol sulfate + excipients.

After inhalation administration, 10 to 20% of the dose enters the respiratory tract. The rest is retained in the device or settles in the oropharynx and is then swallowed. Part of the dose that remains in the respiratory tract is absorbed by lung tissue without being metabolized in the lungs and enters the bloodstream. Once in the systemic circulation, it can be metabolized in the liver and excreted primarily in the urine unchanged or in the form of phenolic sulfate. The degree of binding of salbutamol to plasma proteins is 10%. Part of the dose received in the gastrointestinal tract is absorbed and undergoes intensive metabolism during the “first pass” through the liver, turning into phenolic sulfate. The unchanged drug and conjugate are excreted primarily in the urine. Most of the dose of salbutamol administered intravenously, orally or by inhalation is eliminated within 72 hours.

  • prevention and relief of bronchospasm in bronchial asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema.

Aerosol for inhalation dosed 100 mcg (sometimes mistakenly called spray).

Tablets 2 mg and 4 mg.

Instructions for use and dosage

Adults and children over 12 years of age: pomkg (1-2 inhalation doses) to relieve asthma attacks. To control the course of mild asthma - 1-2 doses 1-4 times a day and moderate severity of the disease - in the same dosage in combination with other anti-asthmatic drugs. To prevent asthma from physical exertion, do 1-2 doses per dose before exercise.

Children from 2 to 12 years old: in the event of an attack of bronchial asthma, as well as to prevent attacks of bronchial asthma associated with exposure to an allergen or caused by physical activity, the recommended dose is mcg (1 or 2 inhalations).

The daily dose should not exceed 800 mcg (8 inhalations).

Instructions for using the inhaler

Check the operation of the inhaler before using it for the first time, and also if you have not used it for some time.

  1. Remove the cap from the inhaler. Make sure there is no dust or dirt in the outlet tube.
  2. Hold the balloon in an upright position with your thumb on the bottom and your index finger on the top of the balloon.
  3. Shake the can vigorously up and down.
  4. Exhale as deeply as possible (without straining). Pinch the outlet tube of the can tightly with your lips.
  5. Take a slow, deep breath. As you inhale, press your index finger on the valve of the canister, releasing a dose of medication. Continue to inhale slowly.
  6. Remove the inhaler tube from your mouth and hold your breath for 10 seconds or as long as you can without straining. Exhale slowly.

If more than one dose of medication is needed, wait about a minute and then repeat from step 2. Replace the cap on the inhaler.

Take your time when performing steps 3 and 4. When releasing a dose of medication, it is important to inhale as slowly as possible. First, practice in front of a mirror. If you notice steam coming out of the top of the can or from the corners of your mouth, start again from step 2.

The inhaler should be cleaned at least once a week. Remove the metal can from the plastic case and rinse the case and cap with warm water. Do not use hot water. Dry thoroughly, but do not use heating devices. Place the canister back into the case and put on the cap. Do not immerse the metal canister in water.

  • tremor of fingers;
  • headache;
  • dizziness;
  • increased excitability;
  • anxiety;
  • sleep disturbance;
  • insomnia;
  • dilation of peripheral blood vessels (facial skin hyperemia);
  • the appearance of chest pain;
  • arthralgia;
  • angioedema;
  • hives;
  • nasal congestion;
  • bronchospasm;
  • muscle cramps;
  • nausea, vomiting;
  • dyspepsia;
  • cough;
  • excitement and increased motor activity in children;
  • the appearance of arrhythmias (including atrial fibrillation, supraventricular tachycardia and extrasystole).
  • rhythm disturbances (paroxysmal tachycardia, polytopic ventricular extrasystole);
  • myocarditis;
  • heart defects;
  • aortic stenosis;
  • cardiac ischemia;
  • tachyarrhythmia;
  • thyrotoxicosis;
  • decompensated diabetes mellitus;
  • glaucoma;
  • epileptic seizures;
  • pyloroduodenal narrowing;
  • renal or liver failure;
  • simultaneous use of non-selective beta-blockers;
  • pregnancy;
  • children under 2 years of age;
  • hypersensitivity to any component of the drug.

Use during pregnancy and breastfeeding

Contraindicated during pregnancy.

During lactation it is prescribed only in cases where the expected benefit to the mother exceeds any possible risk to the child.

Children from 2 to 12 years old: in the event of an attack of bronchial asthma, as well as to prevent attacks of bronchial asthma associated with exposure to an allergen or caused by physical activity, the recommended dose is mcg (1 or 2 inhalations).

In patients with severe or unstable asthma, the use of bronchodilators should not be the main or only method of therapy. If the effect of the usual dose of Salamol Eco becomes less effective or shorter lasting (the effect of the drug should last for at least 3 hours), the patient should consult a doctor.

Frequent use of salbutamol can lead to increased bronchospasm and sudden death, and therefore it is necessary to take breaks of several hours between doses of the drug.

An increased need for the use of inhaled beta2-adrenergic agonists with a short duration of action to control the symptoms of bronchial asthma indicates an exacerbation of the disease. In such cases, the patient's treatment plan should be reviewed and the issue of prescribing or increasing the dose of inhaled or systemic glucocorticosteroids (GCS) should be decided.

Therapy with beta2-adrenergic agonists may lead to hypokalemia. Particular caution is recommended when treating severe attacks of bronchial asthma, since in these cases hypokalemia may increase as a result of the simultaneous use of xanthine derivatives, corticosteroids, diuretics, as well as due to hypoxia. In such situations, it is necessary to monitor the level of potassium in the blood serum.

The salbutamol cylinder must not be punctured, disassembled or thrown into fire, even if it is empty. Like most other inhalation aerosol products, salbutamol may be less effective at low temperatures. When cooling the cylinder, it is recommended to remove it from the plastic case and warm it with your hands for a few minutes.

To determine the reversibility of bronchial obstruction and assess the effectiveness of therapy, tests with bronchodilators (bronchodilators), such as Salbutamol, are used.

This medicine contains ethanol (alcohol). This fact must be taken into account when driving a vehicle.

Theophylline and other xanthines, when used simultaneously with salbutamol, increase the likelihood of developing tachyarrhythmias; agents for inhalation anesthesia, levodopa - severe ventricular arrhythmias.

It is not recommended to use Salamol Eco and non-selective beta-adrenergic receptor blockers, such as propranolol, at the same time.

MAO inhibitors and tricyclic antidepressants enhance the effect of salbutamol and can lead to a sharp decrease in blood pressure.

Salbutamol enhances the effect of central nervous system stimulants, the side effects of thyroid hormones, cardiac glycosides.

Reduces the effectiveness of antihypertensive drugs and nitrates.

Hypokalemia may increase as a result of the simultaneous use of xanthine derivatives, corticosteroids, and diuretics.

Simultaneous administration with anticholinergic drugs (including inhaled ones) may increase intraocular pressure.

Analogues of the drug Salbutamol

Structural analogues of the active substance:

Source: http://instrukciya-otzyvy.ru/749-salbutamol-po-primeneniyu-analogi-aerozol-sprey-dlya-ingalyaciy-tabletki-astma-sostav.html

Salbutamol in Moscow

Instructions

Beta-adrenergic agonist with a predominant effect on β 2 -adrenergic receptors (localized, in particular, in the bronchi, myometrium, blood vessels). Prevents and relieves bronchospasm; reduces resistance in the respiratory tract, increases the vital capacity of the lungs. Prevents the release of histamine, a slow-reacting substance from mast cells and neutrophil chemotaxis factors. Compared to other drugs in this group, it has a less pronounced positive chrono- and inotropic effect on the myocardium. Causes expansion of the coronary arteries, practically does not reduce blood pressure. It has a tocolytic effect, reducing the tone and contractile activity of the myometrium.

When using an aerosol, rapid absorption of salbutamol into the blood is observed; however, its plasma concentrations when used at recommended doses are very low or do not reach the detection limit.

After oral administration, salbutamol is well absorbed from the gastrointestinal tract. Plasma protein binding is 10%. Metabolized on first pass through the liver and possibly in the intestinal wall; the main metabolite is an inactive sulfate conjugate. Salbutamol is not metabolized in the lungs, so its ultimate metabolism and elimination after inhalation depends on the route of administration, which determines the ratio between inhaled and inadvertently ingested salbutamol.

T1 /2 from blood plasma is 2-7 hours. Salbutamol is quickly excreted in the urine in the form of metabolites and unchanged substance; excreted in small quantities in feces.

Prevention and relief of bronchospasm in all forms of bronchial asthma. Reversible airway obstruction in chronic bronchitis and emphysema, broncho-obstructive syndrome in children.

Threatened premature birth with contractile activity of the uterus; childbirth before weeks of pregnancy; isthmic-cervical insufficiency, a decrease in fetal heart rate depending on uterine contractions during periods of cervical dilatation and expulsion. For preventive purposes during operations on the pregnant uterus (application of a circular suture in case of insufficiency of the internal os of the uterus).

Orally as a bronchodilator for adults and children over 12 years of age - 2-4 mg 3-4 times a day, if necessary, the dose can be increased to 8 mg 4 times a day. Children aged 6-12 years - 2 mg 3-4 times a day; children 2-6 years old mg 3 times a day.

When administered by inhalation, the dose depends on the dosage form used, the frequency of use depends on the indications and the clinical situation.

As a tocolytic agent, it is administered intravenously in a dose of 1-2 mg.

From the cardiovascular system: transient dilatation of peripheral vessels, moderate tachycardia.

From the central nervous system: headache, dizziness, nausea, vomiting.

Metabolism: hypokalemia.

Allergic reactions: in isolated cases - angioedema, allergic reactions in the form of skin rash, urticaria, arterial hypotension, collapse.

Other: tremor of the hands, internal trembling, tension; rarely - paradoxical bronchospasm, muscle cramps.

Salbutamol is contraindicated in cases of threatened miscarriage in the first and second trimesters of pregnancy, premature placental abruption, bleeding or toxicosis in the third trimester of pregnancy.

If it is necessary to use salbutamol during pregnancy, the expected benefits of treatment for the mother should be weighed against the potential risk to the fetus. Currently, there is insufficient data on the safety of the use of salbutamol in early pregnancy. Salbutamol is excreted in breast milk, so if it is necessary to use it during lactation, the expected benefit of treatment for the mother and the possible risk for the child should also be assessed.

With simultaneous use of salbutamol with non-cardioselective beta-blockers, mutual suppression of therapeutic effects is possible; with theophylline - the risk of developing tachycardia and arrhythmia, in particular supraventricular extrasystole, increases.

With the simultaneous use of salbutamol and xanthine derivatives, corticosteroids or diuretics, the risk of developing hypokalemia increases.

Use with caution for tachyarrhythmias and other heart rhythm disorders, arterial hypertension, myocarditis, heart defects, aortic stenosis, diabetes mellitus, thyrotoxicosis, glaucoma, acute heart failure (subject to careful medical supervision).

Increasing the dose or frequency of taking salbutamol should be done under the supervision of a physician. Reducing the interval is possible only in exceptional cases and must be strictly justified.

When using salbutamol, there is a risk of developing hypokalemia, therefore, during treatment in patients with severe bronchial asthma, the level of potassium in the blood should be monitored. The risk of hypokalemia increases with hypoxia.

Source: http://www.rusanalogi.ru/preparaty/salbutamol

How to use Salbutamol for inhalation correctly

Is it possible to relieve an acute asthma attack in 120 seconds? Aerosol Salbutamol for inhalation, characterized by rapid action, will help relieve such conditions. Relief will occur within the first 5 minutes after use. The effect will last several hours, and the medication itself will completely leave the body after 72 hours. Partial half-life occurs within 4-6 hours from the moment of application.

Description of the drug

A bronchodilator with a tocolytic and bronchodilator effect. Included in the group of beta 2-adrenergic agonists.

Relieves the symptoms of bronchospastic syndrome. Helps reduce the tone of the respiratory muscles during spasm. Prevents the penetration of histamine into the extracellular space. Helps you breathe deeply by increasing lung capacity. Dilates the coronary arteries of the heart. Helps relieve phlegm. Reduces potassium concentration and insulin production.

Implemented in the form:

  • tablets of various shapes;
  • powder for inhalation;
  • capsules;
  • syrup;
  • solution for injection;
  • aerosol.

Pharmacies also sell Salbutamol inhalation solution. However, you will need a prescription to purchase.

Indications for use

The drug is prescribed for the following ailments and pathological conditions:

  • emphysema;
  • broncho-obstructive syndrome;
  • chronic obstructive pulmonary disease;
  • asthmatic bronchitis;
  • bronchospasm;
  • chronic form of bronchitis;
  • premature birth.

According to the instructions, Salbutamol is also used during long-term maintenance therapy for bronchitis, as well as for preventive purposes during nocturnal asthma attacks.

Salbutamol aerosol

Opaque white or almost white liquid with a specific but not pungent odor. The medicine is placed in an aluminum container of white-green or white color. The bottle is equipped with a dosing valve and a nozzle. Pressing the valve results in dosed spraying.

The list of active substances is presented by salbutamol. The list of additional components includes oleyl and ethyl alcohol, propellant R 134a.

Instructions for use of Salbutamol for inhalation

The dosage directly depends on the age group of the patient.

If the patient is already 12 years old, and the drug is involved in the complex therapy of COPD or bronchial asthma, then the recommended single dose is 100 mcg. It is allowed to use the product every 6 hours, and for young children aged 2 to 6 years - no more than 3 times a day.

Salbutamol can be used to relieve a severe attack in a young patient. Dosage: 1-2 inhalations. It is also suitable for the prevention of suffocation, spasms when encountering an allergen, and performing exercises. You need to resort to it in advance. One minute before intended contact or physical activity. Dosage: 1-2 inhalations.

Adults

The best option: 2 inhalations every 6 hours for complex therapy of chronic respiratory diseases. One or two presses on the bottle are enough to relieve an attack of suffocation.

Recommendations

The instructions for use for Salbutamol for inhalation say that the use of a new inhaler is possible only after a thorough check. The algorithm of actions is simple. Remove the cap, shake the bottle several times, and turn it upside down. Spray 3-4 doses into the air. If during the experiment a stuck valve or other defect is discovered, do not use the drug. The inhaler is faulty.

Side effects and contraindications

While taking the medication, problems with the cardiovascular, genitourinary, immune, musculoskeletal and central nervous systems may occur. Pathological manifestations of various types on the skin are possible.

In the instructions for use of Salbutamol, the list of negative consequences from taking it is divided into 3 groups according to the principle of frequency.

First group

Phenomena that are observed more often than others:

  • internal trembling of inexplicable etymology;
  • tremor of the fingers and limbs (the upper section is most often involved);
  • sleep disorders (drowsiness, insomnia, nightmares);
  • high heart rate.

Second group

Less commonly, patients complain of the following manifestations and conditions:

  • causeless irritability;
  • migraines, which are difficult to relieve with painkillers;
  • nausea at different times of the day;
  • dermatitis;
  • persistent drowsiness;
  • change in taste perception;
  • distinct hyperemia;
  • disorientation in space;
  • decreased performance, speed of thought processes;
  • false vomiting;
  • Steven-Johnson syndrome;
  • problems with concentration;
  • tides.

Third group

Rare side effects fall into this category. They often appear in people suffering from chronic diseases that are not directly related to the pulmonary system. The drug simply acts as a catalyst.

The following manifestations are possible:

  • auditory, visual hallucinations;
  • anxiety and panic conditions;
  • ventricular fibrillation;
  • convulsions;
  • cough;
  • unmotivated aggressiveness;
  • angioedema;
  • hypokalemia;
  • schizophrenia-like personality disorders;
  • allergic reactions of various types, but skin rashes are more common;
  • hives;
  • unstable mental state;
  • irritation of mucous membranes;
  • decreased blood pressure;
  • heart collapse;
  • bronchospasm;
  • urinary retention;
  • cardiovascular failure;
  • hyperactivity, hyperexcitability;
  • supraventricular tachycardia.

When using the drug, you should also take into account the patient's age and medical history. Hypersensitivity to components significantly increases the likelihood of side effects.

You should use Salbutamol with caution in case of the following ailments and pathological conditions:

  • diseases of the endocrine gland;
  • tachycardias of various types;
  • hyperthyroidism;
  • hypertension.

Children who have not yet turned 2 years old, as well as persons with individual intolerance to the components, have a complete exemption.

You should absolutely not use medication for the following ailments:

  • glaucoma;
  • renal failure;
  • myocarditis;
  • heart disease;
  • tachyarrhythmia;
  • liver failure;
  • aortic stenosis;
  • diabetes;
  • obstruction of the lumen of the cardiac artery;
  • thyrotoxicosis.

In case of diagnosed epilepsy and pregnancy aggravated by medical history, Salbutomol therapy is not carried out. The greatest harm will be caused to the fetus and its mother if a woman uses the medicine in the later stages and when there is a threat of miscarriage.

Intravenous use can cause:

  • birth canal infection;
  • premature placental abruption;
  • intrauterine death.

In the postpartum period, when breastfeeding, the decision on the advisability of using the drug is made by the attending physician. At the same time, the risks for the baby are compared with the consequences of refusing treatment. The properties of the active substances of the drug, their ability to penetrate and accumulate in breast milk are taken into account.

special instructions

Medical personnel are obliged:

  • instruct the patient before using the inhaled drug for the first time;
  • notify him of the consequences of ignoring the rules and regulations;
  • make sure that the patient has trained in front of a mirror;
  • be personally present at the first application.

Persons using Salbutamol should be under medical supervision at the beginning of therapy. This period, like the end of the course of treatment, is characterized by a high probability of side effects. The risks increase if the medication is abruptly discontinued. Complications may also arise during long-term use.

It is prohibited to independently adjust the dosage, reduce or increase the duration of the course and the intervals between use. Only the attending physician has the right to make such decisions.

The doctor should be notified of any changes in condition. You should not refuse medication based on an unpleasant taste or sensation in the mouth. To eliminate the phenomenon, the patient should gargle.

If the problem is caused by a reduction in the duration of the effect, a sharp worsening of asthma or general condition, it is prohibited to take medications with a similar composition, as this can lead to an overdose. You should seek qualified medical help.

In case of a severe attack of suffocation, the interval between inhalations should not be shorter than 20 minutes. Ignoring the prescription will lead to the fact that each subsequent attack will be more difficult and acute than the previous one, and the medication itself will bring relief only for a short period of time.

Compatibility issues also require caution. The following points need to be taken into account:

  • the Salbutamol inhaler reduces the effectiveness of nitrates and antihypertensive drugs;
  • simultaneous use of this medication and anticholinergic drugs increases intraocular pressure;
  • tricyclic antidepressants enhance the effect of Salbutamol.

Analogs

A similar mechanism of action is characterized by:

  • Clenbuterol. Available in the form of syrup and tablets. Indicated for bronchial asthma and chronic diseases of the pulmonary system. It can be used to treat young children. May cause nausea, urticaria, convulsions. Sold according to prescription.
  • Berotek. Available in the form of a solution for inhalation, an inhalation metered aerosol. Indicated for chronic obstructive pulmonary diseases, emphysema, bronchospasm, reversible narrowing of the airways. It is taken for preventive purposes in case of exercise-induced asthma. May cause the development of diseases of the cardiovascular and central nervous systems. Other negative manifestations: myalgia, weakness, sharp drop in blood pressure, vomiting, cough. Contraindicated in chronic heart valve diseases, heart defects, diabetes mellitus, glaucoma. It should not be used by children under 4 years of age.
  • Onbrez Breezhaler. Available in the form of capsules for inhalation. The kit also includes a breathhaler. It differs from its analogues in the age threshold for patients. Contraindicated for minors. Dispensed by prescription. It cannot be used to relieve bronchospasm.
  • Foradil. White elongated capsules in blisters. They differ in speed. The patient begins to feel well almost immediately after taking it. It gets better within the first 3 minutes. Another advantage: it has virtually no negative effect on the cardiovascular system. Patients who are already 5 years old can resort to the remedy.

Structural analogues of Salbutamol:

  • Saltos. Long-acting bronchodilator tablets. Prescribed for nocturnal attacks of breathlessness, emphysema, and bronchial asthma. They have virtually no side effects; unpleasant manifestations occur only when the dosage is exceeded. Indicated for adults and children over 6 years of age.
  • Ventolin. Aerosol, inhalation solution, syrup and tablets. It doesn't last that long, only 5 hours. Prescribed for COPD, chronic bronchitis, bronchial asthma. It is not prescribed to minors, pregnant or lactating women.

Other medications with similar composition and principle of action:

Opinions about the drug

If you read the reviews on Salbutamol, you can conclude that a lengthy list of side effects should not stop you from carrying out therapy with this drug. The number of people whose medication caused complications is not large enough. Most users, on the contrary, noted a significant improvement in well-being without any negative manifestations from the cardiovascular or central nervous system.

People also often point out the availability of the drug. This is especially clearly visible if you compare it with foreign analogues. The cost of the medicine varies between 2-3 hundred rubles depending on the region and packaging.

The drug is available in various forms, so it is not difficult to choose the optimal solution for a particular patient. The dosage and frequency are quite easy to determine. You just need to remember that Salbutmol for inhalation is used no more than 4 times, and tablets - no more than 3 times a day. The list of contraindications and side effects is long, but complications occur only in a small group of people. In general, the medication is quite convenient, relatively safe, and is successfully used in complex therapy.

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