Acetylcysteine ​​instructions for use

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Acetylcysteine ​​- instructions for use, analogs, reviews and release forms (effervescent tablets, powder 100 mg, 200 mg and 600 mg, solution for inhalation and rinsing) medications for the treatment of cough with sputum in adults, children and pregnancy.

Table of contents:

Compound

In this article you can read the instructions for use of the drug Acetylcysteine. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Acetylcysteine ​​in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Acetylcysteine ​​analogues in the presence of existing structural analogues. Use for the treatment of bronchitis, pneumonia and other diseases accompanied by cough with sputum in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Acetylcysteine ​​is a mucolytic agent and is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates the discharge of sputum due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum.

It has an antioxidant effect due to the ability of its reactive sulfhydryl groups (SH groups) to bind to oxidative radicals and thus neutralize them.

In addition, acetylcysteine ​​promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine ​​increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Acetylcysteine ​​+ excipients.

When taken orally, it is well absorbed from the gastrointestinal tract. Substantially undergoes first pass effect through the liver, resulting in decreased bioavailability. Binding to plasma proteins up to 50% (4 hours after oral administration). Metabolized in the liver and possibly in the intestinal wall. In plasma it is determined unchanged, as well as in the form of metabolites - N-acetylcysteine, N,N-diacetylcysteine ​​and cysteine ​​ester. Renal clearance accounts for 30% of the total clearance.

Respiratory diseases and conditions accompanied by the formation of viscous and mucopurulent sputum:

  • acute and chronic bronchitis;
  • tracheitis due to bacterial and/or viral infection;
  • pneumonia;
  • bronchiectasis;
  • bronchial asthma;
  • atelectasis due to blockage of the bronchi by mucus plug;
  • sinusitis (to facilitate the passage of secretions);
  • cystic fibrosis (as part of combination therapy).

Removal of viscous secretions from the respiratory tract in post-traumatic and postoperative conditions.

Effervescent tablets 200 mg and 600 mg.

Powder for solution for oral administration 100 mg and 200 mg.

Solution for inhalation.

Instructions for use and dosage regimen

Inside. Adults - 200 mg 2-3 times a day in the form of granules, tablets or capsules.

Children 2-6 years old - 200 mg 2 times a day or 100 mg 3 times a day in the form of a water-soluble granulate; younger than 2 years mg 2 times a day; 6-14 years mg 2 times a day.

For chronic diseases for several weeks: adults mg per day in 1-2 doses; children 2-14 years old mg 3 times a day; for cystic fibrosis - children from 10 days to 2 years - 50 mg 3 times a day, 2-6 years mg 4 times a day, over 6 years mg 3 times a day in the form of a water-soluble granulate, effervescent tablet or in capsules.

Inhalation. For aerosol therapy, 20 ml of a 10% solution or 2-5 ml of a 20% solution are sprayed in ultrasound devices; in devices with a distribution valve - 6 ml of a 10% solution. Duration of inhalation minutes; frequency: once a day. When treating acute conditions, the average duration of therapy is days; for long-term therapy of chronic conditions, the course of treatment is up to 6 months. In the case of a strong secretolytic effect, the secretion is sucked out, and the frequency of inhalations and the daily dose are reduced.

Intratracheal. To wash the bronchial tree during therapeutic bronchoscopy, use a 5-10% solution.

Locally. Instill into the nasal passages (for 1 procedure).

Parenterally. Administer intravenously (preferably drip or slow stream over 5 minutes) or intramuscularly. Adults - 300 mg 1-2 times a day.

Children from 6 to 14 years old - 150 mg 1-2 times a day. For children under 6 years of age, oral administration is preferable; for children under 1 year of age, intravenous administration of acetylcysteine ​​is possible only for health reasons in a hospital setting. If there are still indications for parenteral therapy, the daily dose for children under 6 years of age should be 10 mg/kg body weight.

For intravenous administration, the solution is further diluted with 0.9% NaCl solution or 5% dextrose solution in a 1:1 ratio.

The duration of therapy is determined individually (no more than 10 days). In patients over 65 years of age, the minimum effective dose is used.

  • heartburn;
  • nausea, vomiting;
  • diarrhea;
  • feeling of fullness in the stomach;
  • skin rash;
  • itching;
  • hives;
  • bronchospasm;
  • with shallow intramuscular injection and in the presence of increased sensitivity, a slight and quickly passing burning sensation may appear, and therefore it is recommended to inject the drug deep into the muscle;
  • reflex cough;
  • local irritation of the respiratory tract;
  • stomatitis;
  • rhinitis;
  • nosebleeds;
  • noise in ears;
  • a decrease in prothrombin time due to the administration of large doses of acetylcysteine ​​(monitoring the state of the blood coagulation system is necessary);
  • changes in the results of the salicylate quantitation test (colorimetric test) and ketone quantitation test (sodium nitroprusside test).
  • peptic ulcer of the stomach and duodenum in the acute phase;
  • hemoptysis;
  • pulmonary hemorrhage;
  • pregnancy;
  • lactation period (breastfeeding);
  • hypersensitivity to acetylcysteine.

Use during pregnancy and breastfeeding

The use of Acetylcysteine ​​is contraindicated during pregnancy and lactation (breastfeeding).

When using acetylcysteine ​​in patients with bronchial asthma, it is necessary to ensure sputum drainage. In newborns, it is used only for health reasons at a dose of 10 mg/kg under the strict supervision of a physician.

Orally for children over 6 years old - 200 mg 2-3 times a day; children aged 2 to 6 years - 200 mg 2 times a day or 100 mg 3 times a day, up to 2 years - 100 mg 2 times a day.

Acetylcysteine ​​is used with caution in patients with bronchial asthma, diseases of the liver, kidneys, and adrenal glands.

A 1-2 hour interval should be observed between taking acetylcysteine ​​and antibiotics.

Acetylcysteine ​​reacts with some materials such as iron, copper and rubber used in the spray device. In places of possible contact with acetylcysteine ​​solution, parts made of the following materials should be used: glass, plastic, aluminum, chromed metal, tantalum, sterling silver or stainless steel. Silver may tarnish after contact, but this does not affect the effectiveness of acetylcysteine ​​and does not harm the patient.

The simultaneous use of acetylcysteine ​​with antitussives may increase sputum stagnation due to suppression of the cough reflex.

When used simultaneously with antibiotics (including tetracycline, ampicillin, amphotericin B), their interaction with the thiol group of acetylcysteine ​​is possible.

When taking acetylcysteine ​​and nitroglycerin simultaneously, the vasodilator and antiplatelet effects of the latter may be enhanced.

Acetylcysteine ​​reduces the hepatotoxic effect of paracetamol.

Pharmaceutically incompatible with solutions of other drugs. On contact with metals and rubber, it forms sulfides with a characteristic odor.

Analogues of the drug Acetylcysteine

Structural analogues of the active substance:

  • N-AC-ratiopharm;
  • N-acetylcysteine;
  • Acestine;
  • Acetylcysteine ​​Canon;
  • Acetylcysteine ​​Teva;
  • Acetylcysteine ​​solution for inhalation 20%;
  • Acetylcysteine ​​solution for injection 10%;
  • Acetylcysteine ​​PS;
  • ACC;
  • ACC injection;
  • ACC Long;
  • AC-FS;
  • Vicks Active ExpectoMed;
  • Mukobene;
  • Mucomist;
  • Mukonex;
  • Fluimucil;
  • Exomyuk 200;
  • Espa-Nat.

Analogs by pharmacological group (secretolytics):

  • Marshmallow syrup;
  • Ambrobene;
  • Ambroxol;
  • Ambrosan;
  • Ambrosol;
  • Ascoril;
  • Bromhexine;
  • Bronchicum;
  • Bronchicum inhalate;
  • Bronchicum cough lozenges;
  • Bronchicum cough syrup;
  • Bronchipret;
  • Bronchostop;
  • Bronchotil;
  • Gedelix;
  • Hexapneumin;
  • GeloMyrtol;
  • Herbion primrose syrup;
  • Herbion plantain syrup;
  • Glycyram;
  • Chest collection;
  • Breast Elixir;
  • Joset;
  • Dr. MOM;
  • Dr. Theiss syrup with plantain;
  • Zedex;
  • Insti;
  • Carbocysteine;
  • Cashnol;
  • Codelac Broncho;
  • Coldact Broncho;
  • Coldrex broncho;
  • Lazolvan;
  • Libexin Muco;
  • Linkas;
  • Mukaltin;
  • Mucosol;
  • Expectorant collection;
  • Pectosol;
  • Pectusin;
  • Pertussin;
  • overslept;
  • Rinicold Broncho;
  • Sinupret;
  • Mixture for inhalation;
  • Licorice syrup;
  • Solutan;
  • Stoptussin;
  • Cough tablets;
  • Terpinhydrate;
  • Travisil;
  • Tussamag;
  • Tussin;
  • Tussin Plus;
  • Fervex for cough;
  • Flavamed;
  • Flavamed forte;
  • Fluifort;
  • Fluditek;
  • Halixol;
  • Erdostein.

Source: http://instrukciya-otzyvy.ru/1467-acetilcistein-po-primeneniyu-analogi-tabletki-shipuchie-poroshok-rastvor-ingalyacii.html

Acetylcysteine

Description current as of 01/06/2015

  • Latin name: Acetylcysteine
  • ATX code: R05CB01
  • Active ingredient: Acetylcysteine
  • Manufacturer: Marbiopharm (Russia)

Compound

Each package of powder, in addition to the main substance, contains the flavoring additive “Aromatic” Lemon, lactose monohydrate, aspartame.

Release form

The medicine is available in the form of a solution for internal use or capsules. In addition, such a release form is known as effervescent tablets.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

It is important to know about acetylcysteine, what it is and what its mechanism of action is before using the drug. It is a derivative of the amino acid cysteine. The effect of the drug Acetylcysteine ​​is due to the fact that its sulfhydryl group cleaves the disulfide bonds of acidic mucopolysaccharides of sputum. This causes a mucolytic effect. Mucoregulatory activity depends on increased secretion of less viscous sialomucins by goblet cells. Bacterial adhesion on epithelial cells of the bronchial mucosa is reduced. This occurs due to a decrease in sputum viscosity and increased mucociliary clearance.

The disinfecting effect of the drug is due to the action of the free sulfhydryl group, which affects electrophilic oxidative toxins, neutralizing them.

This drug protects cells from free radicals both through direct interaction with them and through the transport of cysteine ​​for the synthesis of glutathione.

The drug is quickly broken down when used internally. But its bioavailability is approximately 10%. The degree of binding to plasma proteins is 50%. The maximum concentration in plasma is observed in minutes. The active substance can cross the placental barrier and accumulate in the amniotic fluid. The half-life is 60 minutes. For liver cirrhosis – up to 8 hours.

Excreted mainly by the kidneys as inactive metabolites. Some part is excreted unchanged by the intestines. In plasma it is determined unchanged and also as a metabolite of N-acetylcysteine, cysteine ​​ester and N,N-diacetylcysteine.

Indications for use

Contraindications

Side effects

The drug may cause adverse reactions such as:

In rare cases, tinnitus, burning at the injection site (if a solution is used), as well as reflex cough, rhinorrhea and local irritation of the respiratory tract when used in inhalation are possible.

Instructions for use of Acetylcysteine ​​(Method and dosage)

Dosages are selected depending on the age and nature of the patient’s disease.

Instructions for use of Acetylcysteine ​​indicate that for children 2–6 years old, a daily dosage of 100 mg 3 times or 200 mg 2 times is usually indicated. The medicine is used in the form of a water-soluble granule. And for children under 2 years of age, a daily dose of 2 times 100 mg is prescribed. In turn, children 6-14 years old are given 200 mg daily 2 times, in the case of cystic fibrosis - 200 mg 3 times. The medicine can be taken in the form of effervescent tablets, capsules or granules.

Adults take 200 mg of the drug 2-3 times every day in any possible form of release.

For aerosol therapy, 20 ml of a 10% solution is sprayed in ultrasonic devices, and 6 ml of a 10% solution is sprayed in devices with a distribution valve. Inhalation is done every day 2-4 times. For acute conditions, therapy lasts 5-10 days, for chronic conditions – up to six months.

With a strong secretolytic effect, it is necessary to suck out the secretion, as well as reduce the frequency of use and dosage of the drug.

Overdose

In case of overdose, the medicine can cause diarrhea, nausea, abdominal pain, heartburn, and vomiting.

Therapy is symptomatic. In case of severe symptoms of overdose, you should urgently consult a specialist.

Interaction

The combination of the drug with oral administration of semisynthetic penicillins, cephalosporins, tetracyclines (except for Doxycycline), aminoglycosides requires a two-hour interval. Acetylcysteine ​​with other antitussive medications can cause dangerous mucus stagnation. When combined with this drug, the vasodilating effect of Nitroglycerin may also increase.

Terms of sale

The drug is approved for over-the-counter release.

Storage conditions

Optimal storage conditions for Acetylcysteine: dry, dark place, out of reach of children, temperature not higher than 25 °C, sealed packaging.

Best before date

Acetylcysteine ​​analogues

The following common analogues of Acetylcysteine ​​are sold:

They are all similar in their action, but may have some application features.

Reviews

This drug receives a variety of reviews. Many of them are positive. Those who have tried this remedy report its effectiveness. However, there are also negative opinions about Acetylcysteine. They write that the drug did not help. Therefore, people often begin to look for other, more effective means.

Acetylcysteine ​​price, where to buy

The price of Acetylcysteine ​​depends on the form in which the drug is produced. Powder for diluting a solution of 200 mg (usually 20 sachets per package) costs about 630 rubles. The price of Acetylcysteine ​​in tablets is at least 60 rubles. In turn, some online stores sell capsules with the same name, the cost of which can be 770 rubles and more.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Ukraine Ukraine

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All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/atsetiltsistein

Acetylcysteine

Content

Structural formula

Russian name

Latin name of the substance Acetylcysteine

Chemical name

N-Acetyl-L-cysteine ​​(as sodium salt)

Gross formula

Pharmacological group of the substance Acetylcysteine

Nosological classification (ICD-10)

CAS code

Characteristics of the substance Acetylcysteine

White or white with a slightly yellowish tint crystalline powder, with a slight specific odor. Easily soluble in water and alcohol; The pH of a 20% aqueous solution is 7–7.5.

Pharmacology

Due to the presence of a free sulfhydryl group, it breaks the disulfide bonds of acidic mucopolysaccharides of sputum, inhibits the polymerization of mucoproteins and reduces the viscosity of mucus.

It thins sputum and significantly increases its volume (in some cases, suction is required to prevent “flooding” of the lungs). It has a stimulating effect on mucosal cells, the secretion of which is lysed by fibrin. Increases glutathione synthesis and activates detoxification processes. It has anti-inflammatory properties due to the suppression of the formation of free radicals and reactive oxygen metabolites responsible for the development of acute and chronic inflammation in the lung tissue and airways.

When taken orally, it is well absorbed, but the bioavailability is low - no more than 10% (during the “first pass” through the liver it is deacetylated to form cysteine), Cmax is achieved after 1–3 hours. Plasma protein binding is about 50%. Penetrates the placental barrier and is found in amniotic fluid. T1 /2 when taken orally is 1 hour, with liver cirrhosis it increases to 8 hours. It is excreted mainly by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine), a small part is excreted unchanged by the intestines.

Application of the substance Acetylcysteine

Difficulty secreting sputum (bronchitis, tracheitis, bronchiolitis, pneumonia, bronchiectasis), cystic fibrosis, lung abscess, emphysema, laryngotracheitis, interstitial lung diseases, bronchial asthma, pulmonary atelectasis (due to blockage of the bronchi with a mucus plug), catarrhal and purulent otitis media, sinusitis, incl. sinusitis, removal of viscous secretions from the respiratory tract in post-traumatic and postoperative conditions, paracetamol poisoning (as an antidote).

Contraindications

Hypersensitivity, peptic ulcer of the stomach and duodenum in the acute stage.

Restrictions on use

Peptic ulcer of the stomach and duodenum, varicose veins of the esophagus, hemoptysis, pulmonary hemorrhage, phenylketonuria, bronchial asthma without thickening of sputum, diseases of the adrenal glands, arterial hypertension, liver and/or kidney failure.

Use during pregnancy and breastfeeding

During pregnancy, it is possible if the expected effect of therapy exceeds the potential risk to the fetus.

FDA category of effect on the fetus is B.

Breastfeeding should be stopped during treatment.

Side effects of the substance Acetylcysteine

From the gastrointestinal tract: nausea, vomiting, heartburn, feeling of fullness in the stomach, stomatitis.

Allergic reactions: skin rash, itching, urticaria, bronchospasm (mainly in patients with bronchial hyperreactivity).

Other: drowsiness, fever; rarely - tinnitus; reflex cough, local irritation of the respiratory tract, rhinorrhea (for inhalation use); burning at the injection site (for parenteral use).

Interaction

The simultaneous use of acetylcysteine ​​and antitussives may increase sputum stagnation due to suppression of the cough reflex (should not be used simultaneously). When used together with antibiotics, such as tetracyclines (excluding doxycycline), ampicillin, amphotericin B, they may interact with the thiol SH group of acetylcysteine, which leads to a decrease in the activity of both drugs (the interval between taking acetylcysteine ​​and antibiotics should be at least 2 hours) . When taking acetylcysteine ​​and nitroglycerin simultaneously, the vasodilator and antiplatelet effects of the latter may be enhanced. Acetylcysteine ​​reduces the hepatotoxic effect of paracetamol. Pharmaceutically incompatible with solutions of other drugs. On contact with metals and rubber, it forms sulfides with a characteristic odor.

Routes of administration

Inside, intravenously, intramuscularly, inhalation, endobronchially, locally.

Precautions for the substance Acetylcysteine

In patients with broncho-obstructive syndrome (develops quite often against the background of increased bronchospasm), acetylcysteine ​​must be combined with bronchodilators.

Interactions with other active ingredients

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Acetylcysteine

Acetylcysteine: instructions for use and reviews

Latin name: Acetylcysteine

ATX code: R05CB01

Active ingredient: acetylcysteine

Manufacturer: Marbiopharm (Russia)

Update of description and photo: 12/01/2017

Prices in pharmacies: from 135 rubles.

Acetylcysteine ​​is a drug with a mucolytic effect used to treat cough.

Release form and composition

Forms of release of the drug:

  • Solution for inhalation (20%);
  • Solution for injection (10%);
  • Powder for the preparation of solution for oral administration.

The main active ingredient of the drug is acetylcysteine.

Pharmacological properties

Pharmacodynamics

Acetylcysteine ​​is a mucolytic drug that thins sputum, increases its volume and makes it easier to separate. Its action is due to the ability of unbound sulfhydryl groups of acetylcysteine ​​to break inter- and intramolecular disulfide bonds of acidic mucopolysaccharides contained in sputum. This causes depolymerization of mucoproteins and a decrease in sputum viscosity, which in some cases provokes a significant increase in sputum volume and requires aspiration of bronchial contents.

Acetylcysteine ​​remains active in diseases accompanied by purulent sputum and does not affect the immune system. The drug intensifies the production of less viscous sialomucins by goblet cells, reduces the adhesion of bacterial microorganisms on epithelial cells localized in the bronchial mucosa, and also activates bronchial mucosal cells that secrete a secretion that lyses fibrin. The effect of the drug on the secretions formed during diseases of the ENT organs of an inflammatory nature is identical.

The drug has an antioxidant effect associated with the presence of the SH group, which neutralizes electrophilic oxidative toxins.

Acetylcysteine ​​protects alpha1-antitrypsin, which is an elastase inhibitor, from the inactivating effects of the HOCI oxidant. The latter is produced by myeloperoxidase of active phagocytes.

The drug is also characterized by a certain anti-inflammatory effect due to inhibition of the formation of reactive oxygen-containing compounds and free radicals responsible for the development of the inflammatory process in the lung tissue.

Pharmacokinetics

Acetylcysteine ​​is highly absorbed. Its bioavailability is 10% due to the presence of a pronounced first-pass effect through the liver. The metabolic process involves deacetylation to form cysteine. The maximum concentration of the substance in plasma is achieved 1–3 hours after oral administration, and the degree of binding to plasma proteins is 50%.

The half-life of acetylcysteine ​​is about 1 hour (in patients with liver cirrhosis, this figure increases to 8 hours). It is excreted in the urine in the form of inactive metabolites (diacetylcysteine, inorganic sulfates). A small part of the administered dose is excreted unchanged in feces.

Acetylcysteine ​​crosses the placental barrier and accumulates in the amniotic fluid.

Indications for use

According to the instructions, Acetylcysteine ​​is used for respiratory diseases and conditions that are accompanied by the formation of mucopurulent and viscous sputum, including:

  • Acute and chronic bronchitis;
  • Tracheitis caused by a bacterial or viral infection;
  • Bronchiectasis;
  • Bronchial asthma;
  • Sinusitis (to facilitate the passage of secretions);
  • Cystic fibrosis (as part of combination therapy);
  • Pneumonia;
  • Atelectasis caused by blockage of the bronchi by a mucus plug.

The drug is also indicated for post-traumatic and postoperative conditions to remove viscous secretions from the respiratory tract.

Contraindications

  • Peptic ulcer of the stomach and duodenum in the acute phase;
  • Pulmonary hemorrhage;
  • Hemoptysis;
  • Hypersensitivity to the drug.

Instructions for use of Acetylcysteine: method and dosage

Acetylcysteine ​​is prescribed to adults and children over 6 years of age once a day (in 2-3 doses).

Children from 2 to 6 years old are recommended to take the drug pomg per day (in 2-3 divided doses), up to 2 years old - 200 mg daily (in 2 divided doses).

Acetylcysteine ​​in the form of an injection solution is administered intramuscularly once a day, for adults - 300 mg, for children - 150 mg.

The drug for inhalation is used in 2-5 ml doses over a period of minutes.

For colds, the drug is taken for 5-7 days. In severe cases of the disease, the duration of treatment is determined individually by the doctor. Treatment of bronchitis and cystic fibrosis requires longer-term use of the drug.

Side effects

Side effects are rare. In some cases, the following undesirable reactions are observed:

  • Heartburn, nausea, vomiting, diarrhea, feeling of a full stomach;
  • Nosebleeds and tinnitus;
  • Skin rash, itching, urticaria, bronchospasm.

When using the drug for inhalation, local irritation of the respiratory tract and reflex cough are possible, and much less often - stomatitis or rhinitis.

With shallow intramuscular injection of the drug, a slight burning sensation may occur.

Overdose

Symptoms of overdose: heartburn, stomach pain, nausea, vomiting, diarrhea. In this case, symptomatic therapy is recommended.

special instructions

The use of Acetylcysteine ​​during pregnancy and breastfeeding is possible only under strict indications.

For bronchial asthma and diseases of the adrenal glands, kidneys and liver, the drug should be used with extreme caution.

An interval of at least 1-2 hours should be maintained between taking antibiotics and Acetylcysteine.

The drug should not be taken simultaneously with antitussives due to suppression of the cough reflex, which can lead to stagnation of sputum.

According to indications, the drug can be used in newborns under strict medical supervision.

Impact on the ability to drive vehicles and complex mechanisms

When driving vehicles and working with complex mechanisms that require increased concentration, the drug must be used with caution.

Use in childhood

When using acetylcysteine ​​in children with bronchial asthma, regular sputum drainage should be ensured. In newborns, it is used only for vital indications under the strict supervision of a specialist and in a dose not exceeding 10 mg/kg.

Drug interactions

Acetylcysteine ​​is pharmacologically incompatible with solutions of other drugs. When the substance comes into contact with metals and rubber, sulfides are formed, which have a characteristic odor.

When acetylcysteine ​​is combined with nitroglycerin, the vasodilator effect of the latter is enhanced. The drug also reduces the absorption of drugs belonging to the group of tetracyclines, cephalosporins or penicillins (they are recommended to be taken no earlier than 2 hours after taking acetylcysteine).

Analogs

Structural analogues of Acetylcysteine ​​are the drugs ACC, Acestin, Fluimucil, Mukonex, N-AC-ratiopharm, Vicks Active.

Storage conditions and periods

It is recommended to store the drug in a dry place at a temperature not exceeding 30 °C.

Shelf life – 3 years.

Conditions for dispensing from pharmacies

Available without a prescription.

Reviews of Acetylcysteine

There are a variety of reviews about Acetylcysteine. Many patients speak positively about it and confirm its effectiveness. However, negative opinions about the drug are also not uncommon: patients claim that the treatment did not help them at all, and they had to look for more effective means.

Price for Acetylcysteine ​​in pharmacies

The average price for Acetylcysteine ​​in powder form for the preparation of a solution for oral administration is 108‒195 rubles (dosage 200 mg, 20 sachets per package), 95‒146 rubles (600 mg dosage, 6‒10 sachets per package) or 103‒ 134 rubles (dosage 100 mg, package includes 20 sachets). Solution for inhalation and solution for injection are currently not commercially available.

Acetylcysteine ​​powder for solution 100 mg No. 20 sachets

Acetylcysteine ​​powder for solution 200 mg No. 20 sachets

Acetylcysteine ​​200 mg No. 24 effervescent tablets

Acetylcysteine ​​600 mg No. 12 effervescent tablets (lemon)

Education: First Moscow State Medical University named after I.M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Source: http://www.neboleem.net/acetilcistein.php

ACETYL CYSTEINE

Mucolytic agent is a derivative of the amino acid cysteine. It has a mucolytic effect, increases the volume of sputum, facilitates its discharge due to a direct effect on the rheological properties of sputum. The action of acetylcysteine ​​is associated with the ability of its sulfhydryl groups to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolarization of mucoproteins and a decrease in sputum viscosity. Remains active in the presence of purulent sputum.

Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs.

It has an antioxidant effect due to the ability of its reactive sulfhydryl groups (SH groups) to bind to oxidative radicals and thus neutralize them.

Acetylcysteine ​​easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant and cytoprotector that neutralizes endogenous and exogenous free radicals and toxins. Acetylcysteine ​​prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, promoting the detoxification of harmful substances. This explains the effect of acetylcysteine ​​as an antidote for paracetamol poisoning.

Protects alpha1-antitrypsin (elastase inhibitor) from the inactivating effects of HOCl, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue).

When taken orally, it is well absorbed from the gastrointestinal tract. It is largely subject to the “first pass” effect through the liver, which leads to a decrease in bioavailability. Binding to plasma proteins up to 50% (4 hours after oral administration). Metabolized in the liver and possibly in the intestinal wall. In plasma it is determined unchanged, as well as in the form of metabolites - N-acetylcysteine, N,N-diacetylcysteine ​​and cysteine ​​ester.

Renal clearance accounts for 30% of the total clearance.

Respiratory diseases and conditions accompanied by the formation of viscous and mucopurulent sputum: acute and chronic bronchitis, tracheitis due to bacterial and/or viral infection, pneumonia, bronchiectasis, bronchial asthma, atelectasis due to blockage of the bronchi with a mucus plug, sinusitis (to facilitate the passage of secretions ), cystic fibrosis (as part of combination therapy).

Preparation for bronchoscopy, bronchography, aspiration drainage.

Removal of viscous secretions from the respiratory tract in post-traumatic and postoperative conditions.

For washing abscesses, nasal passages, maxillary sinuses, middle ear, treatment of fistulas, surgical field during operations on the nasal cavity and mastoid process.

Peptic ulcer of the stomach and duodenum in the acute phase, hemoptysis, pulmonary hemorrhage, pregnancy, lactation (breastfeeding), hypersensitivity to acetylcysteine.

Contraindications for use in children under 14 years of age depend on the dosage form and are indicated in the instructions for use of the drug used.

Orally for adults and children over 6 years old - 200 mg 2-3 times a day; children aged 2 to 6 years - 200 mg 2 times / day or 100 mg 3 times / day, up to 2 years - 100 mg 2 times / day.

Parenteral: IM for adults - 300 mg 1 time/day, for children - 150 mg 1 time/day.

Administer intravenously (preferably drip or slow stream over 5 minutes) or intramuscularly. Adults - 300 mg 1-2 times/day; children from 6 to 14 years old - 150 mg 1-2 times a day. The daily dose for children under 6 years of age is 10 mg/kg body weight; in children under 1 year of age, intravenous administration of acetylcysteine ​​is possible only for health reasons in a hospital setting. The duration of treatment should be determined based on changes in the patient's condition.

For inhalation and intratracheal use, the dose, frequency of use and course duration are set individually.

Locally - instilled into the external auditory canal and nasal passages (1.5-3 ml) for 1 procedure.

From the digestive system: rarely - heartburn, nausea, vomiting, diarrhea, feeling of fullness in the stomach.

Allergic reactions: rarely - skin rash, itching, urticaria, bronchospasm.

With shallow intramuscular injection and in the presence of increased sensitivity, a slight and quickly passing burning sensation may appear, and therefore it is recommended to inject the drug deep into the muscle.

When used by inhalation: reflex cough and local irritation of the respiratory tract are possible; rarely - stomatitis, rhinitis.

Other: rarely - nosebleeds, tinnitus.

From the laboratory parameters: a decrease in prothrombin time is possible due to the administration of large doses of acetylcysteine ​​(monitoring the state of the blood coagulation system is necessary), changes in the results of the test for the quantitative determination of salicylates (colorimetric test) and the test for the quantitative determination of ketones (sodium nitroprusside test).

The simultaneous use of acetylcysteine ​​with antitussives may increase sputum stagnation due to suppression of the cough reflex.

When used simultaneously with antibiotics (including tetracycline, ampicillin, amphotericin B), their interaction with the thiol group of acetylcysteine ​​is possible.

Acetylcysteine ​​reduces the hepatotoxic effect of paracetamol.

Use with caution in the following diseases and conditions: history of gastric and duodenal ulcers; bronchial asthma, obstructive bronchitis; liver and/or kidney failure; histamine intolerance (long-term use should be avoided, since acetylcysteine ​​affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching); varicose veins of the esophagus; adrenal gland diseases; arterial hypertension.

When using acetylcysteine ​​in patients with bronchial asthma, it is necessary to ensure sputum drainage. In newborns, it is used only for health reasons at a dose of 10 mg/kg under the strict supervision of a physician.

A 1-2 hour interval should be observed between taking acetylcysteine ​​and antibiotics.

Acetylcysteine ​​reacts with some materials such as iron, copper and rubber used in the spray device. In places of possible contact with acetylcysteine ​​solution, parts made of the following materials should be used: glass, plastic, aluminum, chromed metal, tantalum, sterling silver or stainless steel. Silver may tarnish after contact, but this does not affect the effectiveness of acetylcysteine ​​and does not harm the patient.

The compliance of the route of administration and the dosage form used should be strictly observed.

Contraindicated for use during pregnancy and lactation (breastfeeding).

When using acetylcysteine ​​in patients with bronchial asthma, it is necessary to ensure sputum drainage. In newborns, it is used only for health reasons at a dose of 10 mg/kg under the strict supervision of a physician.

Orally for children over 6 years old - 200 mg 2-3 times a day; children aged 2 to 6 years - 200 mg 2 times / day or 100 mg 3 times / day, up to 2 years - 100 mg 2 times / day.

To ask a question about the project or contact the editors, use this form.

Source: http://health.mail.ru/drug/acetylcysteine/

Acetylcysteine

acetylcysteine) together with rimantadine?

It’s better to try starting with herbal expectorant syrups; there are quite a few of them in pharmacies. But you can also try using drugs such as Acetylcysteine ​​(ACC), Bromhexine or the like.

Of course, the contraindications given in the drug instructions and individual tolerance should be taken into account.

However, it is better to stop smoking or at least reduce smoking.

Tell me, is it possible to take ACC if you are injecting ceftriaxone? IN

the instructions for the ACC say that the ACC is not compatible with

tetracycline, so they should be taken orally no earlier than after

2 hours after taking acetylcysteine.

ACC interaction: enhances the vasodilator and other effects of nitroglycerin. Incompatible with cough suppressants (possible accumulation of mucus in the respiratory tract). Reduces the absorption of penicillins, cephalosporins, tetracycline, erythromycin (an interval of 2 hours between doses is required). There is no interaction information regarding thiazole derivatives (SULBUTIAMINE). I think ACC will not destroy sulbutiamine.

Sulbutiamine is rapidly absorbed from the gastrointestinal tract, the maximum concentration is achieved 1-2 hours after administration. If in doubt, take your medications at different times or find an alternative to ACC.

The information provided is intended for medical and pharmaceutical professionals, should not be used for treatment and cannot be considered as official. The most accurate information about the drug is contained in the instructions supplied with the packaging by the manufacturer. No information posted on this or any other page of our website can serve as a substitute for personal contact with a specialist.

Please pay attention to the specified dates for entering information; information may become outdated.

Source: http://www.webapteka.ru/drugbase/name740.html

Acetylcysteine

Effervescent tablets are white or almost white, round, flat-cylindrical, with a chamfer, a rough surface and a weak characteristic odor.

Excipients: ascorbic acid - 25 mg, sodium carbonate anhydrous - 93 mg, sodium bicarbonate mg, citric acid anhydrous mg, sorbitol mg, macrogol mg, sodium citrate mg, sodium saccharinate - 8 mg, lemon flavor - 20 mg.

12 pcs. — polypropylene pencil cases (1) — cardboard packs.

4 things. — cellular contour packages (3) — cardboard packs.

2 pcs. — cellless contour packages (6) — cardboard packs.

Mucolytic agent is a derivative of the amino acid cysteine. It has a mucolytic effect, increases the volume of sputum, facilitates its discharge due to a direct effect on the rheological properties of sputum. The action of acetylcysteine ​​is associated with the ability of its sulfhydryl groups to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolarization of mucoproteins and a decrease in sputum viscosity. Remains active in the presence of purulent sputum.

Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs.

It has an antioxidant effect due to the ability of its reactive sulfhydryl groups (SH groups) to bind to oxidative radicals and thus neutralize them.

Acetylcysteine ​​easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant and cytoprotector that neutralizes endogenous and exogenous free radicals and toxins. Acetylcysteine ​​prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, promoting the detoxification of harmful substances. This explains the effect of acetylcysteine ​​as an antidote for paracetamol poisoning.

Protects alpha1-antitrypsin (elastase inhibitor) from the inactivating effects of HOCl, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue).

When taken orally, it is well absorbed from the gastrointestinal tract. It is largely subject to the “first pass” effect through the liver, which leads to a decrease in bioavailability. Binding to plasma proteins up to 50% (4 hours after oral administration). Metabolized in the liver and possibly in the intestinal wall. In plasma it is determined unchanged, as well as in the form of metabolites - N-acetylcysteine, N,N-diacetylcysteine ​​and cysteine ​​ester.

Renal clearance accounts for 30% of the total clearance.

Respiratory diseases and conditions accompanied by the formation of viscous and mucopurulent sputum: acute and chronic bronchitis, tracheitis due to bacterial and/or viral infection, pneumonia, bronchiectasis, bronchial asthma, atelectasis due to blockage of the bronchi with a mucus plug, sinusitis (to facilitate the passage of secretions ), cystic fibrosis (as part of combination therapy).

Preparation for bronchoscopy, bronchography, aspiration drainage.

Removal of viscous secretions from the respiratory tract in post-traumatic and postoperative conditions.

For washing abscesses, nasal passages, maxillary sinuses, middle ear, treatment of fistulas, surgical field during operations on the nasal cavity and mastoid process.

Orally for adults and children over 6 years old - 200 mg 2-3 times a day; children aged 2 to 6 years - 200 mg 2 times / day or 100 mg 3 times / day, up to 2 years - 100 mg 2 times / day.

Parenteral: IM for adults - 300 mg 1 time/day, for children - 150 mg 1 time/day.

Administer intravenously (preferably drip or slow stream over 5 minutes) or intramuscularly. Adults - 300 mg 1-2 times/day; children from 6 to 14 years old - 150 mg 1-2 times a day. The daily dose for children under 6 years of age is 10 mg/kg body weight; in children under 1 year of age, intravenous administration of acetylcysteine ​​is possible only for health reasons in a hospital setting. The duration of treatment should be determined based on changes in the patient's condition.

For inhalation and intratracheal use, the dose, frequency of use and course duration are set individually.

Locally - instilled into the external auditory canal and nasal passages (1.5-3 ml) for 1 procedure.

From the digestive system: rarely - heartburn, nausea, vomiting, diarrhea, feeling of fullness in the stomach.

Allergic reactions: rarely - skin rash, itching, urticaria, bronchospasm.

With shallow intramuscular injection and in the presence of increased sensitivity, a slight and quickly passing burning sensation may appear, and therefore it is recommended to inject the drug deep into the muscle.

When used by inhalation: reflex cough and local irritation of the respiratory tract are possible; rarely - stomatitis, rhinitis.

Other: rarely - nosebleeds, tinnitus.

From the laboratory parameters: a decrease in prothrombin time is possible due to the administration of large doses of acetylcysteine ​​(monitoring the state of the blood coagulation system is necessary), changes in the results of the test for the quantitative determination of salicylates (colorimetric test) and the test for the quantitative determination of ketones (sodium nitroprusside test).

Peptic ulcer of the stomach and duodenum in the acute phase, hemoptysis, pulmonary hemorrhage, pregnancy, lactation (breastfeeding), hypersensitivity to acetylcysteine.

Contraindications for use in children under 14 years of age depend on the dosage form and are indicated in the instructions for use of the drug used.

Contraindicated for use during pregnancy and lactation (breastfeeding).

When using acetylcysteine ​​in patients with bronchial asthma, it is necessary to ensure sputum drainage. In newborns, it is used only for health reasons at a dose of 10 mg/kg under the strict supervision of a physician.

Orally for children over 6 years old - 200 mg 2-3 times a day; children aged 2 to 6 years - 200 mg 2 times / day or 100 mg 3 times / day, up to 2 years - 100 mg 2 times / day.

Use with caution in the following diseases and conditions: history of gastric and duodenal ulcers; bronchial asthma, obstructive bronchitis; liver and/or kidney failure; histamine intolerance (long-term use should be avoided, since acetylcysteine ​​affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching); varicose veins of the esophagus; adrenal gland diseases; arterial hypertension.

When using acetylcysteine ​​in patients with bronchial asthma, it is necessary to ensure sputum drainage. In newborns, it is used only for health reasons at a dose of 10 mg/kg under the strict supervision of a physician.

A 1-2 hour interval should be observed between taking acetylcysteine ​​and antibiotics.

Acetylcysteine ​​reacts with some materials such as iron, copper and rubber used in the spray device. In places of possible contact with acetylcysteine ​​solution, parts made of the following materials should be used: glass, plastic, aluminum, chromed metal, tantalum, sterling silver or stainless steel. Silver may tarnish after contact, but this does not affect the effectiveness of acetylcysteine ​​and does not harm the patient.

The compliance of the route of administration and the dosage form used should be strictly observed.

The simultaneous use of acetylcysteine ​​with antitussives may increase sputum stagnation due to suppression of the cough reflex.

When used simultaneously with antibiotics (including tetracycline, ampicillin, amphotericin B), their interaction with the thiol group of acetylcysteine ​​is possible.

Acetylcysteine ​​reduces the hepatotoxic effect of paracetamol.

A description of the active substances of the drug is presented. The scientific information provided is general and cannot be used to make a decision about the possibility of using a particular drug.

There are contraindications, consult your doctor.

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Source: http://health.yandex.ru/pills/acetilcistein-44020