Tetrizoline instructions

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Tetrizoline*

PRESCRIPTION MEDICINES ARE PRESCRIBED TO THE PATIENT ONLY BY A DOCTOR. THIS INSTRUCTION IS FOR MEDICAL PROFESSIONALS ONLY.

Description of the active substance Tetrizoline/Tetryzoline.

Formula: C13H16N2, chemical name: 4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole (as hydrochloride).

Pharmacological group: vegetotropic agents/adrenomimetic agents/Alpha-adrenomimetics; organotropic drugs/ophthalmic drugs; organotropic agents/respiratory agents/anticongestants.

Pharmacological action: anticongestive, vasoconstrictor.

Pharmacological properties

Tetrizoline has a stimulating effect on alpha-adrenergic receptors. When used topically in the form of eye drops, it reduces swelling of the conjunctiva, sensations of irritation, burning, soreness, itching of the mucous membrane of the eyes, and reduces lacrimation. When applied topically in the form of nasal drops, it narrows the small arterioles of the nasal passages, reduces secretion and reduces swelling of the nasal mucosa. The effects of tetrizoline develop within a few minutes and last 4 – 8 hours. When used topically, tetrizoline is almost not absorbed.

Indications

Nasal drops: swelling of the nasal mucosa in people who suffer from rhinitis, sinusitis, pharyngitis, hay fever; if it is necessary to carry out therapeutic and diagnostic measures to reduce swelling of the nasal mucosa.

Eye drops: swelling of the conjunctiva, irritation of the conjunctiva (when exposed to physical and chemical factors, including dust, smoke, chlorinated water, cosmetics, bright light, contact lenses), secondary hyperemia in allergic eye diseases, catarrhal conjunctivitis.

Method of administration of tetrizoline and dose

Intranasally, patients over 6 years old - 0.1% solution, 2-4 drops, children 2-6 years old - 0.05% solution, 2-3 drops in each nasal passage with an interval of at least 3 hours. Tetrizoline should not be used for more than 3 to 5 days (except on doctor's recommendations). Re-use is possible only after a break of several days.

Conjunctivally, 2 - 3 times a day, 1 - 2 drops in each eye in the lower conjunctival sac. Do not use continuously for more than 4 days without consulting an ophthalmologist. If there is no improvement within 2 days, then therapy should be discontinued.

The dosage regimen should be strictly observed. Overdose and prolonged use should be avoided. With prolonged use there is a risk of developing toxic effects. The possibility of overdose, which is caused by systemic absorption of tetrizoline, is increased in young children (especially if accidentally swallowed). Tetrizoline eye drops should only be used for mild eye irritation. If hyperemia and irritation of the conjunctiva are associated with an infectious process, chemical injury to the cornea, or the presence of a foreign body, then consultation with an ophthalmologist is necessary. If within 2 days after starting to use eye drops, the symptoms of the disease become more pronounced, persist, or an adverse reaction develops, then it is necessary to discontinue the drug and consult an ophthalmologist. If you develop a headache, intense pain in the eyes, blurred vision, redness of the eyes, sudden appearance of floating spots in front of the eyes, double vision or pain when exposed to light, you should immediately consult a doctor. Contact lenses are removed before instillation of the drug and reinstalled 15 minutes after it. Due to the possible deterioration of the clarity of soft contact lenses, direct contact of eye drops with them should be avoided. During therapy, care should be taken when working with machinery and driving a car (after using eye drops, blurred vision and pupil dilation may occur).

Contraindications for use

Hypersensitivity; nasal drops: up to 2 years of age (for a 0.05% solution), up to 6 years (for a 0.1% solution), dry rhinitis; eye drops: age up to 2 years, severe eye pathology (dry eye syndrome, glaucoma, epithelial endothelial dystrophy of the cornea).

Restrictions on use

Severe pathology of the circulatory system (including arrhythmia, coronary heart disease, arterial hypertension, cardiac aneurysm), diabetes mellitus, hyperthyroidism, pheochromocytoma, period of therapy with drugs that increase blood pressure, including monoamine oxidase inhibitors.

Use during pregnancy and breastfeeding

Due to the risk of systemic adverse reactions, the use of tetrizoline during pregnancy and breastfeeding is possible only after careful comparison of the expected benefit to the mother and the possible risk to the child or fetus. It is not known whether tetrizoline is excreted in breast milk. There are no reproductive studies in animals.

Side effects of tetrizoline

Organ of vision: increased intraocular pressure, dilated pupils, reactive hyperemia, burning sensation;

nervous system: headache, drowsiness, tremor, weakness, sleep disturbance, dizziness;

digestive system: nausea;

cardiovascular system: cardiac dysfunction, palpitations, arterial hypertension;

endocrine system: hyperglycemia;

respiratory system: when using drops in the nose - a tingling and burning sensation in the nose, dryness of the nasal cavity, sneezing; if the dose is exceeded or prolonged use - the development of secondary edema and hyperemia of the nasal mucosa;

other: allergic reactions.

Interaction of tetrizoline with other substances

Tetrizoline is incompatible with monoamine oxidase inhibitors (risk of developing hypertension).

Overdose

In case of an overdose of tetrizoline, pupil dilation, cyanosis, nausea, fever, tachycardia/bradycardia, convulsions, arterial hypertension, shock-like syndrome with bradycardia and hypotension, and dizziness develop. In children, an overdose can manifest itself as depression of the central nervous system, which is accompanied by excessive sweating, drowsiness, severe hypotension, even shock. Necessary: ​​taking activated carbon, gastric lavage, symptomatic treatment (use of anticonvulsants, antipyretics, oxygen inhalation); There is no specific antidote.

Source: http://xn——8kceunaflgjrqyoqfbei8dxl.xn--p1ai/%D1%82%D0%B5%D1%82%D1%80%D0%B8%D0%B7%D0%BE%D0%BB%D0 %B8%D0%BD

Tetrizoline

Manufacturer: LLC "Pharmtekhnologiya" Republic of Belarus

ATS code: R01AA06

Release form: Liquid dosage forms. Nasal drops.

General characteristics. Compound:

Active ingredient: 0.5 mg or 1.0 mg tetrahydrozoline hydrochloride.

Excipients: benzalkonium chloride, sorbitol non-crystallizing solution, povidone, disodium edetate, sodium citrate, benzyl alcohol, concentrated hydrochloric acid, purified water.

A nasal drug with a predominant decongestant and vasoconstrictor effect.

Pharmacological properties:

Pharmacodynamics. Tetrahydrozoline hydrochloride belongs to the group of sympathomimetics and has a direct stimulating effect on alpha-adrenergic receptors of the sympathetic nervous system. However, it has no or almost no effect on beta-adrenergic receptors. As a sympathomimetic amine, the drug has a vasoconstrictor and decongestant effect when it comes into contact with the nasal mucosa, which leads to a narrowing of the small arterioles of the nasal passages, a decrease in swelling of the nasal mucosa and a decrease in secretion.

Pharmacokinetics. After topical application, the effect develops within 1 minute and lasts 4-8 hours. When applied topically, tetrahydrozoline hydrochloride is practically not absorbed, but systemic absorption of the drug cannot be ruled out in patients with damage to the mucous membrane and epithelium.

Indications for use:

— to reduce swelling of the nasal mucosa before diagnostic procedures.

Directions for use and dosage:

Tetrizoline, nasal drops 1.0 mg/1 ml. If there are no other prescriptions, then adults and children over 6 years of age are prescribed 2-4 drops of the drug in each nostril 3-5 times a day.

Tetrizoline, nasal drops 0.5 mg/1 ml. If there are no other prescriptions, children aged 2 to 6 years are prescribed 2-3 drops of the drug in each nostril 3-4 times a day.

Tetrizoline should be used no more than once every 4 hours.

As a rule, less frequent use of the drug is sufficient, since in most cases the drug has a long-lasting effect (often up to 8 hours). A single use of the drug before bedtime relieves nasal congestion throughout the night, but may cause insomnia due to the effect of tetrizoline on the central nervous system.

Tetrizoline can be used for a short time. The duration of treatment should be no more than 5 days for adults and no more than 3 days for children. The drug can be re-prescribed after a few days.

Features of application:

In patients with severe cardiovascular diseases (for example, coronary heart disease (CHD), arterial hypertension, arrhythmia, aneurysm, pheochromocytoma) and metabolic disorders (hyperthyroidism, diabetes), in patients taking MAO inhibitors or other drugs that increase blood pressure, Tetrizoline can be used only after careful comparison of the possible benefits and risks for the patient.

Too frequent use or prolonged (more than 5-7 days) use of Tetrizoline, as well as use of the drug in high doses, can lead to a burning sensation and dryness of the nasal mucosa, as well as the development of reactive edema and drug-induced rhinitis.

Long-term use of imidazole derivatives can have a damaging effect on the mucosa, suppressing the activity of the ciliated epithelium. Irreversible damage to the mucosa can lead to the development of dry rhinitis.

Using nasal drops at night may cause insomnia because tetrizoline affects the central nervous system.

Use during pregnancy and breastfeeding. Since there is a possibility of systemic side effects (mainly vasoconstrictor effects), the use of the drug during pregnancy and lactation is possible only after careful comparison of the possible benefits to the mother and the risk to the fetus (child).

Impact on the ability to drive a car and other moving mechanisms. After long-term use of the drug in dosages exceeding the recommended ones, a general effect on the cardiovascular system and central nervous system cannot be excluded. In these cases, the ability to operate a vehicle or operate machinery may be reduced.

Side effects:

From the organ of vision: dilated pupils, increased intraocular pressure, reactive hyperemia.

From the central nervous system: headache; when using drops in the nose - drowsiness, weakness, tremor, dizziness, sleep disturbance (insomnia).

From the digestive system: nausea.

From the cardiovascular system: arterial hypertension, cardiac dysfunction, tachycardia.

From the endocrine system: hyperglycemia, sweating.

From the respiratory system: when using nasal drops - a burning and tingling sensation in the nose, sneezing, dry nasal cavity; with prolonged use or exceeding the dose - the development of secondary edema of the nasal mucosa.

Other: allergic reactions.

Interaction with other drugs:

With the simultaneous administration of MAO blockers and tricyclic antidepressants, an increase in blood pressure is possible. Co-administration of other vasoconstrictor drugs increases the risk of side effects.

Contraindications:

- hypersensitivity to the components of the drug;

- children under 2 years of age (tetrizoline solution 0.5 mg/1 ml);

- children under 6 years of age (tetrizoline solution 1.0 mg/1 ml).

Overdose:

Symptoms of overdose are mydriasis, nausea, cyanosis, fever, muscle twitching, tachycardia, arrhythmia, asystole, arterial hypertension, pulmonary edema, respiratory dysfunction, and mental disorders.

In some cases, excessive absorption of imidazole derivatives by α-sympathomimetics can cause depression of the central nervous system, which manifests itself in the form of drowsiness, decreased body temperature, bradycardia, shock-like hypotension, apnea and coma.

There is no specific antidote. The use of stimulant drugs is contraindicated. Although the symptoms of an overdose are quite threatening, they usually go away easily and the patient recovers quickly.

Therapeutic measures for overdose. If necessary, activated charcoal is used, gastric lavage is performed, oxygen therapy is performed, fever is treated, and anticonvulsants are used. To lower blood pressure, 5 mg of phentolamine is administered slowly intravenously in an isotonic saline solution, or 100 mg is prescribed orally. In case of hypotension, vasoconstrictor drugs are contraindicated. If anticholinergic symptoms develop, physostigmine should be used as an antidote.

Storage conditions:

Store at a temperature not exceeding +25 °C. Keep out of the reach of children. Shelf life: 2 years.

Vacation conditions:

Package:

10 ml and 20 ml in plastic bottles, sealed with a nozzle-type spray nozzle or 10 ml in polyethylene bottles, sealed with a screw cap with a safety ring and a dropper insert, placed together with a consumer leaflet in cardboard packs.

Published: March 31, 2015

Similar drugs

Means used in ophthalmology. Decongestants and antiallergic agents. Sympathomimetics used as decongestants. Tetrizoline.

A drug with vasoconstrictor and antiallergic effects for topical use

Anticongestant - vasoconstrictor (alpha-adrenergic agonist).

A drug with a vasoconstrictor effect for local use in ophthalmology.

Source: http://www.24farm.ru/preparats/tetrizolin_farmtehnologija/

Tetrizoline: instructions for use

Almost every mother encounters a runny nose in children regularly. Having an effective remedy for this uncomfortable symptom on hand is every woman’s dream. Let's consider the features of the use of Tetrizoline hydrochloride, which is considered one of the most commonly prescribed drugs for rhinitis and more.

Pharmacological properties

Tetrizoline hydrochloride has two main pharmacological actions:

  • Vasoconstrictor.
  • Anticongestive (relieves swelling of the mucous membrane).

Leads to stimulation of alpha adrenergic receptors. If used topically in the form of eye drops, it helps reduce swelling of the conjunctiva and reduce burning and itching sensations. It also relieves soreness in the eye mucosa and stops lacrimation.

When using the drug in the form of drops for the nasal cavity, there is a spasm of small blood vessels, a decrease in swelling of the nasal mucosa and a decrease in mucus secretion. If Tetrizoline hydrochloride is administered topically, there is virtually no systemic absorption.

It only takes a few minutes for the therapeutic effect to develop. The duration of pharmacological action lasts for 4-8 hours.

Indications

Today, Tetrizoline hydrochloride is successfully used in ophthalmological and otolaryngological practice. For what pathological conditions can this drug be recommended:

  • Runny nose.
  • Swelling of the nasal mucosa in children and adults, which can be observed with rhinitis, pharyngitis, sinusitis, etc.
  • If it is necessary to reduce swelling of the nasal mucosa to carry out diagnostic and therapeutic procedures.
  • Swelling and redness of the conjunctiva.
  • If you feel unpleasant discomfort, burning and itching in the area of ​​the conjunctiva of the eyes.
  • To quickly and effectively stop lacrimation.

Contraindications

Depending on the type of medication (eye or nasal drops), there will be corresponding contraindications, which are described in detail in the instructions for use. When not to use Tetrizoline hydrochloride, available in eye drops:

  1. The presence of hypersensitivity to the active substance of the drug.
  2. Glaucoma, when there is an increase in intraocular pressure.
  3. Dry keratoconjunctivitis. This disease is also called “dry eye” syndrome.
  4. Significant thinning of the cornea, which is characteristic of epithelial-endothelial dystrophy of the outer transparent membrane of the eye.
  5. Children under three years of age.
  6. Simultaneously use with drugs from the MAO inhibitor group (antidepressants).

Contraindications for nasal drops:

  • The presence of hypersensitivity to the active substance of the drug.
  • Atrophic inflammation of the nasal mucosa (dry rhinitis).
  • 0.05% drops are contraindicated in children under two years of age.
  • 0.1% drops cannot be used to treat children under 6 years of age.
  • Simultaneous use with drugs from the MAO inhibitor group (antidepressants).

For what diseases and pathological conditions should the drug Tetrizoline hydrochloride be prescribed with extreme caution:

  • Severe pathologies of the cardiovascular system (coronary disease, arterial hypertension, arrhythmia, aneurysm, etc.).
  • Hyperthyroidism.
  • Diabetes mellitus.
  • Pheochromocytoma.

Tetrizoline hydrochloride is not used as an injection.

Side effects

When using the drug Tetrizoline hydrochloride, various adverse reactions may develop. What undesirable effects can be expected from the use of eye drops:

  • The pupil dilates.
  • Intraocular pressure increases.
  • There is a burning sensation and redness of the eye.

What side effects can be observed from the administration of nasal drops:

  • Burning and tingling sensation in the nasal cavity.
  • Frequent attacks of sneezing.
  • The appearance of dry mucous membrane of the nasal passages.
  • In case of prolonged use or increasing dosage, secondary edema and redness of the nasal mucosa are noted.

Systemic adverse reactions:

  • Headaches of varying intensity.
  • Dizziness.
  • Fatigue and fatigue.
  • The appearance of tremor.
  • Sleep disturbance.
  • High blood pressure.
  • Feeling of heartbeat.
  • Nausea.
  • Development of allergic reactions.

Pregnancy and breastfeeding

According to the official instructions for use, Tetrizoline hydrochloride can be prescribed by the attending physician if the potential benefits significantly outweigh the possible risks for the woman and fetus. There are no clinically confirmed data on the penetration of the active substance into breast milk. Targeted studies on the safety of using the drug during pregnancy and breastfeeding have not been conducted.

Overdose

In case of an overdose of Tetrizoline hydrochloride, the following clinical symptoms may develop:
  • The pupil dilates.
  • Temperature rise.
  • Nausea.
  • Convulsive attacks.
  • Blood pressure increases.
  • Fast/slow heartbeat.
  • State of shock.
  • Drowsiness.
  • Suppression of the functions of the central nervous system (lethargy, dizziness, impaired attention, etc.).

What treatment measures should be taken to get rid of the symptoms of a drug overdose? First of all, it is necessary to carry out an effective gastric lavage and take activated carbon or similar drugs with adsorbing properties. If the situation requires it, symptomatic therapy is used. It should be noted that there is no specific antidote (antidote).

The use of Tetrizoline hydrochloride in the form of drops for the eyes or nasal cavity should be agreed with the attending physician.

special instructions

It is recommended to strictly adhere to the dosage regimen and frequency of use of the drug. Prolonged use may result in adverse reactions. Under no circumstances should you use MAO inhibitors (antidepressants) together with medications from the group.

The possibility of purchasing a medicinal product without a prescription does not provide any reason to neglect the consultation of a doctor or pharmaceutical specialist.

Price and analogues

Tetrizoline hydrochloride is produced by both domestic and foreign pharmaceutical companies. For example, this drug under the commercial name Tizin costs about 170 rubles for a 10 ml bottle of 0.05% solution. The following similar drugs with the active substance tetrizoline hydrochloride are currently available:

When choosing an effective medicine, be sure to take into account the opinion and recommendations of a specialist. In most cases, the cost of foreign analogues is an order of magnitude more expensive than domestic drugs. Please note that some analogues of Tetrizoline hydrochloride are available exclusively in the form of eye drops.

Source: http://elaxsir.ru/lekarstva/drugie-lekarstva/gidroxlorid-tetrizolina.html

TETRIZOLINE, active ingredient

TETRYZOLINE - Latin name of the active substance TETRIZOLINE

ATX codes for TETRIZOLINE

S01GA52 (Tetrizoline in combination with other drugs)

Before using TETRIZOLINE you should consult your doctor. These instructions for use are for informational purposes only. For more complete information, please refer to the manufacturer's instructions.

TETRIZOLINE: Clinical and pharmacological groups

26.014 (Drug with antiallergic and vasoconstrictor effects for local use in ophthalmology)

26.012 (Drug with vasoconstrictor effect for local use in ophthalmology)

24.029 (Vasoconstrictor drug for local use in ENT practice)

TETRIZOLINE: Pharmacological action

Sympathomimetic. When applied topically, it causes a vasoconstrictor effect that develops within a few minutes and persists for a long time.

TETRIZOLINE: Pharmacokinetics

When applied topically, systemic absorption is low.

TETRIZOLINE: Dosage

Individual, depending on the indications and the dosage form used.

TETRIZOLINE: Drug interactions

Incompatible with MAO inhibitors.

TETRIZOLINE: Pregnancy and lactation

Tetrizoline should be used with caution during pregnancy and lactation (breastfeeding).

TETRIZOLINE: Side effects

From the organ of vision: dilated pupils, increased intraocular pressure, reactive hyperemia.

From the central nervous system: headache; when using drops in the nose - drowsiness, weakness, tremor, dizziness, sleep disturbance.

From the digestive system: nausea.

From the cardiovascular system: arterial hypertension, cardiac dysfunction.

From the endocrine system: hyperglycemia.

From the respiratory system: when using nasal drops - a burning and tingling sensation in the nose, sneezing, dry nasal cavity; with prolonged use or exceeding the dose - the development of secondary edema of the nasal mucosa.

Other: allergic reactions.

TETRIZOLINE: Indications

Minor eye irritation; itching, swelling and hyperemia of the conjunctiva, burning, lacrimation, injection of the sclera, caused by chemical and physical factors (dust, cosmetics, swimming in chlorinated water, exposure to bright light); allergic conjunctivitis.

Swelling of the mucous membrane of the nasal cavity and nasopharynx.

TETRIZOLINE: Contraindications

Hypersensitivity to tetrizoline. For the use of eye drops: glaucoma, epidermal endothelial dystrophy of the cornea, children under 3 years of age, concomitant use of MAO inhibitors. Children under 6 years of age are contraindicated in 0.1% nasal drops.

TETRIZOLINE: Special instructions

Continuous use of eye drops for more than 4 days is not recommended. If signs of eye irritation persist after 48 hours, stop using tetrizoline and consult a doctor.

Tetrizoline is used with caution in cases of arterial hypertension, arrhythmia, aneurysm, hyperthyroidism, pheochromocytoma, diabetes mellitus, severe organic diseases of the heart and blood vessels (including coronary heart disease), and during treatment with drugs that increase blood pressure.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, it is necessary to refrain from engaging in potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions (the possibility of developing visual impairment).

Experimental determination of drug analogues:

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ATX codes for TETRIZOLINE

S01GA52 (Tetrizoline in combination with other drugs)

Experimental determination of drug analogues:

  • Русский
  • VIZOPTIC 26.012 (Drug with vasoconstrictor effect for local use in ophthalmology)…
  • MONTEVIZIN 26.012 (A drug with a vasoconstrictor effect for local use in ophthalmology)…
  • NAFAZOLINE Clinical and pharmacological groups 26.020 (A drug with antimicrobial and antiallergic effects for topical use…
  • OXYMETAZOLINE 24.029 (Vasoconstrictor drug for topical use in ENT practice) Adrenomimetic…
  • VIZIN CLASSIC 26.012 (A drug with a vasoconstrictor effect for topical use in…
  • TRAMAZOLIN 24.029 (Vasoconstrictor drug for topical use in ENT practice) Alpha adrenergic agonist.…
  • TRIMAZOLINE 24.029 (Vasoconstrictor drug for topical use in ENT practice) Alpha adrenergic agonist.…
  • TIMOLOL Clinical and pharmacological groups 26.003 (Antiglaucoma drug - beta-blocker) 25.007 (Phytopreparation with anti-inflammatory, antimicrobial and…
  • XYLOMETAZOLINE 24.029 (Vasoconstrictor drug for local use in ENT practice) Vasoconstrictor…
  • OCTILIA 26.012 (Drug with vasoconstrictor effect for local use in ophthalmology)…
  • PHENYLEPHRINE Clinical and pharmacological groups 24.029 (Vasoconstrictor drug for local use in ENT practice) 24.035 (Drug with…
  • BURA Clinical and pharmacological groups 25.003 (Antiseptic with hemostatic effect for local use in dentistry) 31.003…

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Tetrizoline

Content

Structural formula

Russian name

The Latin name of the substance is Tetrizoline

Chemical name

4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole (as hydrochloride)

Gross formula

Pharmacological group of the substance Tetrizoline

Nosological classification (ICD-10)

CAS code

Characteristics of the substance Tetrizoline

Tetrizoline hydrochloride is easily soluble in water and alcohol, very slightly soluble in chloroform, practically insoluble in ether. The pH of a 1% aqueous solution is 5.0–6.5. Molecular weight 236.75.

Pharmacology

Stimulates alpha adrenergic receptors. When applied topically in the form of eye drops, it reduces swelling of the conjunctiva, burning sensation, irritation, itching, soreness of the mucous membrane of the eyes, and lacrimation.

When used in the form of nasal drops, it causes a narrowing of the small arterioles of the nasal passages, reduces swelling of the nasal mucosa and reduces secretion.

When applied topically, it is practically not absorbed. The effect develops within a few minutes and lasts 4–8 hours.

Application of the substance Tetrizoline

Swelling of the conjunctiva, secondary hyperemia in allergic eye diseases, irritation of the conjunctiva (as a result of exposure to chemical and physical factors, including smoke, dust, chlorinated water, bright light, cosmetics, contact lenses), catarrhal conjunctivitis.

Swelling of the nasal mucosa in patients suffering from rhinitis, pharyngitis, sinusitis, hay fever, as well as to reduce swelling of the nasal mucosa if diagnostic and therapeutic measures are necessary.

Contraindications

Hypersensitivity; eye drops: severe eye diseases (glaucoma, dry eye syndrome, epithelial endothelial corneal dystrophy), children under 2 years of age; nasal drops: dry rhinitis, children up to 2 years of age (0.05% solution), up to 6 years of age (0.1% solution).

Restrictions on use

Severe cardiovascular diseases (including ischemic heart disease, arrhythmia, cardiac aneurysm, arterial hypertension), hyperthyroidism, diabetes mellitus, pheochromocytoma, period of treatment with drugs that increase blood pressure, incl. MAO inhibitors.

Use during pregnancy and breastfeeding

Due to the likelihood of systemic side effects, use during pregnancy and breastfeeding is possible only after careful comparison of the possible benefits to the mother and the risk to the fetus or child. No reproductive studies have been conducted in animals. It is not known whether tetrizoline is excreted into breast milk.

Side effects of the substance Tetrizoline

Eye drops: pupil dilation, increased intraocular pressure, burning sensation and reactive hyperemia of the eye.

Nasal drops: burning and tingling in the nose, sneezing, dry nasal mucosa; with prolonged use or exceeding the dose - secondary edema, hyperemia of the nasal mucosa.

Systemic effects: headache, dizziness, weakness, tremor, insomnia, increased blood pressure, palpitations, nausea, hyperglycemia, allergic reactions.

Interaction

Incompatible with MAO inhibitors (possible development of hypertension).

Overdose

Symptoms: pupil dilation, nausea, cyanosis, fever, convulsions, tachycardia/bradycardia, arterial hypertension, dizziness, shock-like syndrome with hypotension and bradycardia. Overdose in children can manifest as depression of the central nervous system, accompanied by drowsiness, excessive sweating, severe hypotension, even shock.

Treatment: administration of activated carbon, gastric lavage, symptomatic therapy (oxygen inhalation, use of antipyretics, anticonvulsants). A specific antidote is unknown.

Routes of administration

Precautions for the substance Tetrizoline

The dosage regimen must be strictly observed. Long-term use and overdose should be avoided. With prolonged use, toxic effects may develop. The risk of overdose due to systemic absorption of the drug is high in newborns and small children (especially if accidentally swallowed).

Tetrizoline in the form of eye drops is advisable to use only for mild eye irritation. If irritation and hyperemia of the conjunctiva are associated with an infectious disease, the presence of a foreign body or chemical injury to the cornea, consultation with an ophthalmologist is necessary.

If within 48 hours after starting the use of eye drops, the symptoms of the disease persist/become more pronounced or a side effect appears, you should stop using the drug and consult an ophthalmologist. If you experience intense eye pain, headache, blurred vision, sudden appearance of floaters in front of your eyes, red eyes, pain when exposed to light, or double vision, you should immediately consult a doctor.

When wearing contact lenses, they are removed before instillation of the drug and reinstalled 15 minutes after it. Direct contact of eye drops with soft contact lenses should be avoided due to possible disruption of their transparency.

During the treatment period, care must be taken when driving a car and operating machinery (after using eye drops, the pupil may dilate and blurred vision may occur).

Interactions with other active ingredients

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Tetrizoline

Runny nose. Swelling of the mucous membrane of the nasal cavity and nasopharynx. Minor eye irritation; itching, swelling and hyperemia (redness) of the conjunctiva (outer shell of the eyes), burning, lacrimation, injection (redness) of the sclera, caused by chemical and physical factors (dust, cosmetics, swimming in chlorinated water, exposure to bright light); allergic conjunctivitis (inflammation of the outer membrane of the eyes).

Sympathomimetic. When used topically, it causes a vasoconstrictor effect that develops within a few minutes and persists for a long time.

For instillation into the nose, a single dose for adults and children over 6 years old is 2-4 drops in each nasal passage; Children aged 2 to 6 years are prescribed a 0.5% solution of drops, a single drop in each nasal passage. Nasal drops should be used at intervals of at least 3 hours.

Eye drops into the lower conjunctival sac (the cavity between the back surface of the lower eyelid and the front surface of the eyeball) of each eye 2-3 times a day.

Continuous use of eye drops for more than 4 days is not recommended. If signs of eye irritation persist after 48 hours, stop using the product and consult a doctor.

Increased sensitivity to the product. For the use of eye drops, glaucoma (increased intraocular pressure), epidermal endothelial dystrophy (thinning) of the cornea (the transparent membrane of the eye), simultaneous use of MAO inhibitors. Children under 3 years of age are not prescribed the product in the form of eye drops. Children under 6 years of age are contraindicated in the use of 0.1% nasal drops.

The product is prescribed with caution for arterial hypertension (high blood pressure), hyperthyroidism (overactive thyroid syndrome), heart disease, diabetes, during treatment with antidepressants, during pregnancy, and breastfeeding.

Dilated pupils, increased intraocular pressure, reactive hyperemia (redness), headache, nausea. Systemic effects are possible - arterial hypertension (increased blood pressure), cardiac dysfunction, hyperglycemia (increased blood sugar levels). Allergic reactions are possible. When using nasal drops, you may experience a burning and tingling sensation in the nose, sneezing, dry nasal cavity, headache, drowsiness, weakness, tremor (trembling of the limbs), dizziness, sleep disturbance, palpitations. With prolonged use or exceeding the dose, secondary edema of the nasal mucosa may develop.

Eye drops in a bottle of 8 ml, 15 ml and in a dropper bottle of 10 ml (1 ml of 500 mcg of tetrizoline hydrochloride). Drops for intranasal (into the nasal cavity) use in a bottle of 15 ml (1 ml - 1 g of tetrizoline), drops for intranasal use for babies in a bottle of 15 ml (1 mlmg of tetrizoline).

Tizin, Visin, Diabenil-T, Octilia.

In a cool place.

Before using Tetrizolin, you should consult your doctor.

The instructions are provided solely for information about Tetrizolin.

Group affiliation:

ALPHABETIC INDEX

Medprep.info is a leading reference book for medications and diseases with detailed instructions and photos.

This material is for educational purposes only and is not intended for medical advice, diagnosis or treatment.

Source: http://medprep.info/drug/medicament/2274

Tetrizoline: description, instructions, price

Tetrizoline price and availability in city pharmacies

Republic, 171″ tipadr=”g. Tyumen, Republic, 171″ href=”/aptechnaya-set-zhivika”>Republic, 171

Republic, 171″ tipadr=”g. Tyumen, Republic, 171″ href=”/aptechnaya-set-zhivika”>Republic, 171

Republic, 171″ tipadr=”g. Tyumen, Republic, 171″ href=”/aptechnaya-set-zhivika”>Republic, 171

Republic, 171″ tipadr=”g. Tyumen, Republic, 171″ href=”/aptechnaya-set-zhivika”>Republic, 171

Valeria Gnarovskaya, 8″ tipadr=”g. Tyumen, Valeria Gnarovskaya, 8″ href=”/aptechnaya-set-zhivika-1″>Valeria Gnarovskaya, 8

Valeria Gnarovskaya, 8″ tipadr=”g. Tyumen, Valeria Gnarovskaya, 8″ href=”/aptechnaya-set-zhivika-1″>Valeria Gnarovskaya, 8

Valeria Gnarovskaya, 8″ tipadr=”g. Tyumen, Valeria Gnarovskaya, 8″ href=”/aptechnaya-set-zhivika-1″>Valeria Gnarovskaya, 8

Valeria Gnarovskaya, 8″ tipadr=”g. Tyumen, Valeria Gnarovskaya, 8″ href=”/aptechnaya-set-zhivika-1″>Valeria Gnarovskaya, 8

Stanislav Karnatsevich, 12″ tipadr=”g. Tyumen, Stanislav Karnatsevich, 12″ href=”/aptechnaya-set-zhivika-2″>Stanislav Karnatsevich, 12

Stanislav Karnatsevich, 12″ tipadr=”g. Tyumen, Stanislav Karnatsevich, 12″ href=”/aptechnaya-set-zhivika-2″>Stanislav Karnatsevich, 12

Stanislav Karnatsevich, 12″ tipadr=”g. Tyumen, Stanislav Karnatsevich, 12″ href=”/aptechnaya-set-zhivika-2″>Stanislav Karnatsevich, 12

Stanislav Karnatsevich, 12″ tipadr=”g. Tyumen, Stanislav Karnatsevich, 12″ href=”/aptechnaya-set-zhivika-2″>Stanislav Karnatsevich, 12

Lenina, 63/1″ tipadr=”g. Tyumen, Lenina, 63/1″ href=”/apteka-122-flora-ao-atd-panatseya”>Lenina, 63/1

Source: http://lek-info.ru/tetrizolin

Tetrizoline: instructions for use

Compound

1 ml of the drug contains 0.5 mg or 1.0 mg of tetrahydrozoline hydrochloride as an active ingredient.

Excipients: benzalkonium chloride, sorbitol non-crystallizing solution, povidone, disodium edetate, sodium citrate, benzyl alcohol, concentrated hydrochloric acid, purified water.

Description

Indications for use

- symptomatic treatment of rhinitis, pharyngitis, sinusitis, hay fever;

— to reduce swelling of the nasal mucosa before diagnostic procedures.

Contraindications

- hypersensitivity to the components of the drug;

— chronic atrophic rhinitis;

- glaucoma (especially angle-closure);

- children under 2 years of age (tetrizoline solution 0.5 mg/1 ml);

- children under 6 years of age (tetrizoline solution 1.0 mg/1 ml).

Pregnancy and lactation

Since there is a possibility of systemic side effects (mainly vasoconstrictor effects), the use of the drug during pregnancy and lactation is possible only after careful comparison of the possible benefits to the mother and the risk to the fetus (child).

Directions for use and doses

Tetrizoline, nasal drops 1.0 mg/1 ml

If there are no other prescriptions, then adults and children over 6 years of age are prescribed 2-4 drops of the drug in each nostril 3-5 times a day.

Tetrizoline, nasal drops 0.5 mg/1 ml

If there are no other prescriptions, children aged 2 to 6 years are prescribed 2-3 drops of the drug in each nostril 3-4 times a day.

Tetrizoline should be used no more than once every 4 hours.

As a rule, less frequent use of the drug is sufficient, since in most cases the drug has a long-lasting effect (often up to 8 hours). A single use of the drug before bedtime relieves nasal congestion throughout the night, but may cause insomnia due to the effect of tetrizoline on the central nervous system.

Tetrizoline can be used for a short time. The duration of treatment should be no more than 5 days for adults and no more than 3 days for children. The drug can be re-prescribed after a few days.

Side effect

From the organ of vision: dilated pupils, increased intraocular pressure, reactive hyperemia.

From the central nervous system: headache; when using drops in the nose - drowsiness, weakness, tremor, dizziness, sleep disturbance (insomnia).

From the digestive system: nausea.

From the cardiovascular system: arterial hypertension, cardiac dysfunction, tachycardia.

From the endocrine system: hyperglycemia, sweating.

From the respiratory system: when using nasal drops - a burning and tingling sensation in the nose, sneezing, dry nasal cavity; with prolonged use or exceeding the dose - the development of secondary edema of the nasal mucosa. Other: allergic reactions.

Overdose

Symptoms of overdose are mydriasis, nausea, cyanosis, fever, muscle twitching, tachycardia, arrhythmia, asystole, arterial hypertension, pulmonary edema, respiratory dysfunction, and mental disorders.

In some cases, excessive absorption of imidazole derivatives by α-sympathomimetics can cause depression of the central nervous system, which manifests itself in the form of drowsiness, decreased body temperature, bradycardia, shock-like hypotension, apnea and coma.

There is no specific antidote. The use of stimulant drugs is contraindicated. Although the symptoms of an overdose are quite threatening, they usually go away easily and the patient recovers quickly.

Therapeutic measures for overdose. If necessary, activated charcoal is used, gastric lavage is performed, oxygen therapy is performed, fever is treated, and anticonvulsants are used. To lower blood pressure, 5 mg of phentolamine is administered slowly intravenously in an isotonic saline solution, or 100 mg is prescribed orally. In case of hypotension, vasoconstrictor drugs are contraindicated. If anticholinergic symptoms develop, physostigmine should be used as an antidote.

Interaction with other drugs

With the simultaneous administration of MAO blockers and tricyclic antidepressants, an increase in blood pressure is possible. Co-administration of other vasoconstrictor drugs increases the risk of side effects.

Features of application

Impact on the ability to drive a car and other moving mechanisms

After long-term use of the drug in dosages exceeding the recommended ones, a general effect on the cardiovascular system and central nervous system cannot be excluded. In these cases, the ability to operate a vehicle or operate machinery may be reduced.

Precautionary measures

In patients with severe cardiovascular diseases (for example, coronary heart disease (CHD), arterial hypertension, arrhythmia, aneurysm, pheochromocytoma) and metabolic disorders (hyperthyroidism, diabetes), in patients taking MAO inhibitors or other drugs that increase blood pressure, Tetrizoline can be used only after careful comparison of the possible benefits and risks for the patient.

Too frequent use or prolonged (more than 5-7 days) use of Tetrizoline, as well as use of the drug in high doses, can lead to a burning sensation and dryness of the nasal mucosa, as well as the development of reactive edema and drug-induced rhinitis.

Long-term use of imidazole derivatives can have a damaging effect on the mucosa, suppressing the activity of the ciliated epithelium. Irreversible damage to the mucosa can lead to the development of dry rhinitis.

Using nasal drops at night may cause insomnia because tetrizoline affects the central nervous system.

Release form

10 ml and 20 ml in plastic bottles, sealed with a nozzle-type spray nozzle or 10 ml in polyethylene bottles, sealed with a screw cap with a safety ring and a dropper insert, placed together with a leaflet for the consumer in cardboard packs.

Storage conditions

Store at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Best before date

2 years. The expiration date is indicated on the packaging.

This medicine should not be used after the date stated on the package.

Conditions for dispensing from pharmacies

The medicine is dispensed without a doctor's prescription.

Tetrizoline analogues, synonyms and group drugs

You should consult your doctor and read the instructions before use.

Source: http://apteka.103.by/tetrizolin-instruktsiya/

Tetrizoline instructions

Tetrizoline hydrochloride

The active substance tetrizoline belongs to the pharmacological groups: anticongestants, alpha-adrenergic agonists, ophthalmic agents.

Tetrizoline has an anticongestive, vasoconstrictive effect.

Tetrizoline hydrochloride is highly soluble in alcohol and water; worse in chloroform; practically insoluble in ether.

Molecular weight of a 1% aqueous solution – 236.75; pH – 5.0-6.5.

Tetrizoline drops

Tetrizoline is produced in the form of drops:

  1. For eyes - in bottles of 8 ml or 15 ml; in dropper bottles of 10 ml (500 µg titrozoline - 1 ml).
  2. For instillation into the nasal cavity, 15 ml bottles are produced. For adults, the concentration is 1 g of tetrizoline per 1 ml; for children 500 mg tetrizoline per 1 ml.

The drug is prescribed with caution for hypertension (including when taking medications that increase blood pressure), cardiovascular disorders, diabetes, thyroid diseases, and concomitant use of antidepressants. During pregnancy and lactation, consultation with a specialist is required, since there is no accurate data on the effect of the drug on the fetus and breast milk.

Possible side effects: dizziness, increased blood pressure, increased heart rate, weakness, allergies, nausea, hyperglycemia, insomnia.

It is very important to follow the dosage to prevent the condition from worsening.

Tetrizoline nasal drops

Tetrizoline is recommended for use for swelling of the nasal mucosa with rhinitis, sinusitis, pharyngitis, hay fever. It can be used before therapeutic and diagnostic measures in the nasal cavity, in cases where it is necessary to reduce swelling.

Dry rhinitis at any age is a contraindication for use. Children, depending on their age, require a weaker solution; it is better to check with your doctor about the safe concentration.

Children from 2-6 years old instill 2-3 drops into each nasal passage, children over 6 years old and adults 2-4 drops. The interval between doses is 3 or more hours.

Burning, dryness, tingling of the nasal mucosa, and sneezing may occur.

Tetrizoline hydrochloride for eyes

Tetrizoline is instilled into the eyes for swelling, mild irritation, itching, and redness of the conjunctiva (the outer lining of the eyes); for burning, redness, lacrimation caused by physical and chemical factors (cosmetics, dust, bright light, etc.); also in the event of allergic conjunctivitis.

Children under 3 years of age are not prescribed eye drops. Drops are also contraindicated in case of severe eye diseases, eye infections, the presence of a foreign body, and the presence of a chemical injury to the cornea.

It is recommended to instill 1-2 drops 2-3 times a day into the cavity between the eyeball and the lower eyelid. Use no more than 4 days. Contact lenses are removed upon use.

If symptoms do not decrease within 48 hours, the drug should be discontinued and consult a doctor.

There is a possibility of pupil dilation, increased intraocular pressure, burning and reactive hyperemia of the eye.

Tetrizoline analogues

Analogues of tetrizoline are: Visin, Octilia, Tizin, Diabentil-t, Montevisin.

Tetrizoline price

The average price is 69.84 hryvnia. The cost varies greatly depending on the volume of the bottle, place of sale and other factors.

Tetrizoline reviews

Maria: I saved money on eye mascara, bought it cheaper, and as a result an allergy developed - my eyes turned red and began to itch. The doctor recommended tetrizoline. And, indeed, already on the first day of use there was a significant improvement. And on the second, all the symptoms completely disappeared. In the end, I was satisfied with the drug.

Galina Vasilievna: I work in a very smoky room, and sometimes my eyes become inflamed, red, and watery. When the first symptoms appear, I immediately drop Tetrizoline, it helps. True, frequent use is undesirable, I try to limit myself.

Source: http://nasmork-rinit.com/meditsinskie-preparaty/288-tetrizolin