Suprastin release form

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Suprastin

Suprastin: instructions for use and reviews

Latin name: Suprastin

ATX code: R06AC03

Active ingredient: Chloropyramine

Manufacturer: EGIS Pharmaceuticals PLC (Hungary)

Update of description and photo: 11/14/2017

Table of contents:

Prices in pharmacies: from 113 rubles.

Suprastin is an antiallergic drug, a blocker of histamine H1 receptors.

Release form and composition

  • solution for intravenous (i.v.) and intramuscular (i.m.) administration: clear, colorless liquid with a slight specific odor (1 ml in ampoules with a dark red code ring and a break point; in a blister pack, 5 ampoules each; in a cardboard box 1 or 2 packages);
  • tablets: disc-shaped, chamfered, SUPRASTIN engraved on one side and a line on the other side; color from grayish-white to white, practically odorless (10 pcs. in blisters, 2 blisters in a cardboard pack; 20 pcs. in dark glass bottles, 1 bottle in a cardboard pack).

1 ampoule with solution contains:

  • active substance: chloropyramine hydrochloride – 20 mg;
  • auxiliary components: water for injection.

1 tablet contains:

  • active substance: chloropyramine hydrochloride – 25 mg;
  • auxiliary components: gelatin, stearic acid, sodium carboxymethyl starch (type A), potato starch, talc, lactose monohydrate.

Pharmacological properties

Pharmacodynamics

Chloropyramine hydrochloride is a chlorinated analogue of tripelenamine (pyribenzamine), a classic antihistamine from the group of ethylenediamine antihistamines. It has an antihistamine and m-anticholinergic effect, has an antiemetic, moderate antispasmodic and peripheral anticholinergic effect.

When taking the drug orally, the therapeutic effect of chloropyramine develops over 15–30 minutes, reaches a maximum within the first hour after administration and lasts at least 3–6 hours.

Pharmacokinetics

  • absorption: chloropyramine hydrochloride after oral administration is almost completely absorbed from the gastrointestinal tract (GIT);
  • distribution and metabolism: the substance is well distributed throughout systems and organs, including the central nervous system (CNS) and is intensively metabolized through the liver enzyme system;
  • excretion: Suprastin is excreted mainly by the kidneys; In children, the rate of drug elimination is higher than in adults.

Indications for use

  • serum sickness;
  • food and drug allergies;
  • hives;
  • conjunctivitis;
  • seasonal and year-round allergic rhinitis;
  • contact dermatitis;
  • eczema in acute and chronic course;
  • allergic reactions to insect bites;
  • skin itching;
  • atopic dermatitis;
  • Quincke's edema (angioedema) - for solution, tablets for this condition are used only as an adjuvant.

Contraindications

  • acute attacks of bronchial asthma;
  • lactase deficiency, lactose intolerance, glucose-galactose malabsorption syndrome (tablets, because 1 piece contains 116 mg of lactose);
  • period of pregnancy and lactation (breastfeeding);
  • age up to 3 years (tablets);
  • neonatal period (full-term and premature babies);
  • hypersensitivity to any of the components of the drug.

Relative contraindications (requiring caution): angle-closure glaucoma, urinary retention and prostatic hyperplasia, liver/kidney dysfunction, cardiovascular disease, old age.

Instructions for use of Suprastin: method and dosage

Pills

Suprastin tablets are taken orally at the same time as food, not chewed and washed down with a sufficient amount of water.

  • children aged 3–6 years: ½ pcs. (12.5 mg) 2 times a day;
  • children aged 6–14 years: ½ pcs. (12.5 mg) 2–3 times a day;
  • children over 14 years old and adult patients: 1 pc. (25 mg) 3–4 times a day; daily dose – 75–100 mg.

If the patient has no side effects, the dose can be gradually increased, but the maximum daily dose should not exceed 2 mg/kg body weight.

The course of therapy depends on the symptoms of the disease, its duration and clinical course.

Solution for IM and IV administration

Suprastin in the form of a solution is administered intravenously and intramuscularly. The drug is administered into a vein only in emergency cases, always under the supervision of a specialist.

Recommended initial doses of Suprastin for children:

  • 1–12 months: ¼ ampoule (0.25 ml) IM;
  • 1–6 years: ½ ampoule (0.5 ml) IM;
  • 6–14 years: ½–1 ampoule (0.5–1 ml) IM.

For adult patients, the drug is recommended to be administered intravenously, in a daily dose of 1–2 ampoules (1–2 ml). In case of severe allergy, treatment should begin with careful, slow intravenous administration of the drug, continuing therapy with intramuscular injections or taking tablets.

The dose may be increased under the control of observed side effects and patient response, but not more than 2 mg/kg body weight.

Side effects

Side effects are usually extremely rare and go away on their own after discontinuation of the drug:

  • hematopoietic system: very rarely - agranulocytosis, leukopenia, hemolytic anemia, other changes in the cellular composition of the blood;
  • central and peripheral nervous system: fatigue, drowsiness, dizziness, tremor, nervous excitement, euphoria, headache, convulsions, encephalopathy;
  • organ of vision: blurred vision, increased intraocular pressure, glaucoma;
  • cardiovascular system: tachycardia, decreased blood pressure (BP), arrhythmia (the direct connection of these side effects with taking the drug is not always proven);
  • digestive system: dry mouth, abdominal discomfort, nausea/vomiting, constipation, diarrhea, loss or increased appetite, epigastric pain;
  • urinary system: urinary retention, difficulty urinating;
  • musculoskeletal system: muscle weakness;
  • other reactions: photosensitivity, hypersensitivity.

If any of the above effects occur, or other negative reactions occur, you should stop taking the drug and immediately consult a doctor.

Overdose

Symptoms of an overdose of chloropyramine hydrochloride are: anxiety, incoordination, convulsions, ataxia, athetosis, hallucinations. In young children: dry mouth, anxiety, agitation, fixed dilated pupils, sinus tachycardia, facial flushing, fever, urinary retention, coma. In adults: facial flushing and fever are observed sporadically, followed by a period of excitement followed by convulsions, post-convulsant depression and coma.

To treat the condition (when taking the drug for a period of no more than 12 hours), gastric lavage is performed, taking into account the anticholinergic effect and antiemetic effect of Suprastin. Activated carbon is prescribed, breathing and blood pressure parameters are monitored, and symptomatic therapy is carried out. If necessary, resuscitation measures are carried out. There is currently no data on a specific antidote for chloropyramine.

special instructions

Taking Suprastin in combination with ototoxic drugs can mask early signs of their negative effect on hearing and the functioning of the vestibular apparatus.

Patients with liver and kidney diseases may require a downward dose adjustment of the drug; therefore, the presence of renal/hepatic insufficiency should be reported to the doctor.

When taking the drug at night, the symptoms of reflux esophagitis may increase.

During therapy with Suprastin, you should refrain from drinking alcoholic beverages, since chloropyramine may enhance the effect of ethanol on the central nervous system.

Long-term use of antihistamines can cause disorders of the hematopoietic system such as agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia. In case of an unexplained increase in temperature in a patient during long-term use of Suprastin, observation of pallor of the skin, jaundice, laryngitis, formation of ulcers in the mouth, the appearance of hematomas, unusual and long-lasting bleeding, it is necessary to conduct an extended clinical blood test to determine the number of formed elements. If the blood formula changes, according to test results, stop taking the drug.

Impact on the ability to drive vehicles and complex mechanisms

Suprastin, especially at the beginning of the course of treatment, can cause increased fatigue, drowsiness, dizziness, and therefore at this time it is prohibited to perform all types of work associated with an increased risk of accidents, including driving vehicles. The duration of the initial period and the degree of restriction on working with complex machines and mechanisms are determined by the doctor individually for each patient.

Use during pregnancy and lactation

Due to the lack of adequate clinical studies of the use of antihistamines during pregnancy, the use of Suprastin by pregnant women, especially in the first trimester and the last month, is possible only if the potential benefit to the mother exceeds the possible risk to the fetus.

If the drug must be used during lactation, breastfeeding should be suspended.

Use in childhood

Suprastin solution is contraindicated for use in children (including premature infants) during the neonatal period, from birth and up to 28 days.

The drug in tablet form is prohibited from giving Suprastin to children under 3 years of age.

For impaired renal function

The drug is used with caution in case of impaired renal function. It may be necessary to change the dosage regimen and reduce the dose, since chloropyramine is excreted mainly by the kidneys.

For liver dysfunction

According to the instructions, Suprastin is used with caution in case of liver dysfunction. A dose reduction may be required due to decreased metabolism in liver disease.

Use in old age

Elderly and debilitated patients should use Suprastin with extreme caution, since antihistamines in these patients are more likely to cause side effects such as dizziness and drowsiness.

Drug interactions

  • barbiturates, M-anticholinergics, opioid analgesics: chloropyramine enhances their effect;
  • monoamine oxidase inhibitors (MAO): may increase and prolong the anticholinergic effect of chloropyramine;
  • Ototoxic drugs: Chloropyramine may mask signs of ototoxicity.

Antihistamines, including Suprastin, can distort the results of skin allergy tests, so you should stop using them several days before the planned test.

Analogs

Analogues of Suprastin are: Diazolin, Alepriv, Chloropyramine, Chlorpyramin-Eskom, Chlorpyramin-Ferein, Histafen, Clarotadine, Kestin, Ketotifen, Lomilan, Loratadine, Rapido, Suprastinex, Peritol, Telfast, Erius.

Terms and conditions of storage

Store at 15–25 °C. Keep away from children.

Shelf life – 5 years.

Conditions for dispensing from pharmacies

The solution for intravenous and intramuscular administration is available by prescription.

Suprastin tablets are available without a prescription.

Reviews about Suprastin

According to reviews, Suprastin is a highly effective, affordable drug that is well tolerated and exhibits high antihistamine activity in adults and children. Tablets are widely used for the treatment of allergic seasonal and year-round rhinoconjunctivitis, urticaria, atopic dermatitis, eczema, itching of various etiologies.

Suprastin solution has proven itself in the treatment of conditions requiring emergency care.

Price for Suprastin in pharmacies

Price for Suprastin:

  • tablets 20 pcs. in packaging - from 110 rubles;
  • solution of 10 ampoules per package – from 150 rubles.

Suprastin 25mg No. 20 tablets

Suprastin tab. 25mg n20

Suprastin tablets 25 mg 20 pcs.

Suprastin 25 mg n20 tablet

Suprastin solution IV and IM 20 mg/ml 1 ml n5

Suprastin solution 20 mg/ml 1 ml 5 pcs.

Suprastin 2% solution for injection 1ml No. 5 ampoules

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Source: http://www.neboleem.net/suprastin

Suprastin for children

Allergic diseases are very common these days and often occur in childhood. One of the medications that can quickly help children with severe manifestations of allergies is suprastin. But, before giving such medicine to your baby, you should find out about its effect on the child’s body, permissible dosages and other nuances of taking suprastin.

Action

Suprastin belongs to the group of antiallergic drugs, since the action of its main substance, called chloropyramine hydrochloride, is to block histamine-sensitive receptors. This reduces the effects of histamine on the body such as swelling, smooth muscle spasms and redness. In addition, suprastin has antiemetic, sedative and hypnotic effects.

After taking Suprastin, the onset of its action should be expected within minutes, and the effect of this drug lasts from 3 to 6 hours. The medicine is excreted primarily through the kidneys.

Release form

Suprastin is available in several forms:

  1. Tablets with a grayish-white tint and no odor. Each tablet contains 25 mg of the main active ingredient, supplemented with lactose, stearic acid, gelatin, talc, sodium carboxymethyl starch and potato starch. The package contains 20 tablets, which can be either in a blister in a cardboard box or in a brown glass bottle.
  2. Ampoules with a solution that can be administered intramuscularly and into a vein. Each ampoule contains 1 ml of a clear, colorless liquid containing 20 mg of chloropyramine hydrochloride combined with water. This form of suprastin is sold in packages of 5 and 10 ampoules.

Is it possible to give suprastin to children?

This drug is approved for children and is often used for various types of allergies in children. The age limit for taking it is only the first month of life, so for babies older than a month it can be given with food or administered by injection in an age-appropriate dosage. It is important to remember that the drug itself does not treat allergies, but only relieves its manifestations, therefore, to get rid of an allergic reaction, it is important to identify allergens together with a doctor and exclude their contact with the child’s body.

Indications

Suprastin is prescribed for:

  • Rhinitis caused by allergies, for example, to pollen.
  • Skin itching.
  • Hives.
  • Quincke's edema.
  • Contact allergic dermatitis.
  • An insect bite that provoked an allergic reaction.
  • Chronic or acute eczema.
  • Atopic dermatitis.
  • Conjunctivitis caused by allergies.
  • Allergies caused by drugs.
  • Food allergies.

If a child has a tendency to allergies, it is quite justified to prescribe suprastin before vaccination for several days before vaccination, as well as for 3 days after vaccination.

Contraindications

The medicine is not given if the child has:

  • An attack of bronchial asthma.
  • Less than 1 month old.
  • Intolerance to the components of the drug.

If the baby has problems with the kidneys or liver, or has serious heart pathologies, the use of Suprastin should be done with extreme caution (the dosage is selected individually).

Side effects

In some children, taking suprastin causes:

  • Drowsiness.
  • Fatigue.
  • Dizziness.
  • Discomfortable sensations in the abdomen.
  • Stool disorders.
  • Changes in appetite.
  • Excitation of the nervous system.
  • Nausea.
  • Tremor.
  • Tachycardia.
  • Decreased blood pressure.
  • Arrhythmia.
  • Decreased leukocyte levels.
  • Headache.
  • Muscle weakness.
  • Problems with urination.
  • Increased intraocular pressure.

As a rule, such effects are temporary, as they disappear immediately after stopping taking Suprastin.

The promotional video for Suprastin can be viewed here:

Dosage

How much to give

The dosage of tableted suprastin, depending on age, will be as follows:

Frequency of medication

2 to 3 times a day

2 to 3 times a day

The injection form of suprastin is prescribed intramuscularly in the following dosages:

Half to whole ampoule

The decision to increase the dosage should be made by the doctor, taking into account the tolerability of the drug and the severity of the child’s condition. The maximum permissible dose of suprastin is 2 mg of the active substance per 1 kg of child weight.

How to give

  • Suprastin tablets up to one year of age are crushed into powder, then mixed with food and given to the baby.
  • For older children, the tablet is given with meals. The child should swallow it without chewing, washing it down with water.
  • The doctor prescribes the drug intramuscularly, adjusting the dose depending on the course of the disease and tolerability of the drug.
  • Intravenous injections of suprastin are used only in severe condition of the child. However, such injections should be prescribed and supervised by an experienced physician.

Features of use in infants

Prescribing Suprastin to an infant, for example, at the age of 3 months, should be carried out only under the supervision of a doctor. If the allergic reaction is not pronounced, the baby is given a powdered tablet mixed with baby food. For children under 6 months of age, the medicine is mixed with breast milk or formula, and at an older age, for example, at 9 months, with a liquid complementary food product. For allergies that require a quick therapeutic effect, intramuscular administration of the drug is used.

Instructions for use

  • For a baby under one year old, take 1/4 tablet of suprastin, place it between two spoons and crush until a powder forms. Add liquid food to the resulting powder, then give the child the medicine from a syringe without a needle or from a spoon, holding the baby upright.
  • For a child older than one year, divide the suprastin tablet into halves or quarters, give the baby the required dose and a glass of water, asking him to swallow the drug and wash it down with water. If the child is unable to swallow the medicine, it can be crushed as for a child under one year old.
  • It is advisable for children to be given medication injections by a healthcare professional. The required dose is taken with a syringe and injected into the child’s buttocks.

Special precautions

  • To store the medicine, choose a place where children cannot find it. The optimal storage temperature is +15+25°C.
  • Do not use suprastin, which has expired (it is 5 years and is indicated on the drug packaging).
  • An overdose of the drug is manifested by anxiety, excitement of the nervous system, redness of the face, tachycardia, dilated pupils, fever and other symptoms. If you suspect that the dose has been exceeded, you should rinse the stomach, give the baby activated charcoal and at the same time call an ambulance.
  • Suprastin can enhance the effect of sedatives, sympatholytics, antidepressants, atropine and tranquilizers, so their combined use should be careful.
  • If the child has kidney or liver pathologies, the dose of the drug is reduced.
  • If you take suprastin and analgin or another analgesic, the analgesic effect will be enhanced.
  • For a quick antipyretic effect, it is possible to use a combination of “suprastin, analgin and no-spa”.
  • Taking suprastin at night for reflux esophagitis can intensify its manifestations.
  • Since the tablets of this medicine contain lactose, it is important to take this into account if a child has problems with carbohydrate metabolism (lactose intolerance, lactase deficiency, galactose or glucose malassorption).

Analogs

If for any reason it is impossible to take Suprastin, this medicine can be replaced by other drugs with antihistamine action, for example:

  • Zyrtec. The medicine is produced in the form of drops for oral administration (approved for children over 6 months old) and in the form of tablets (given to children over 6 years old).
  • Tavegil. The medicine is represented by injection ampoules and syrup, used in children over 1 year of age, as well as tablets, which are prescribed for children over 6 years of age.
  • Claritin. It is produced in the form of syrup for children aged 2 years and older, but is also available in tablets prescribed to children who are already 3 years old.
  • Zodak. This drug is given in drops to children over one year old, and in tablet form - from 6 years of age.
  • Loratadine-Hemofarm. The medicine is a syrup (given from the age of 2) and tablets from which an effervescent drink is prepared (used from the age of 6).
  • Fenistil. The drug is produced in the form of drops, which can be given to babies from the age of 1 month.
  • Erius. This medicine in the form of syrup is prescribed to children over one year old, and the tablet form is prescribed from the age of 12.

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Suprastin ® (Suprastin ® )

Active substance:

Content

Pharmacological group

Nosological classification (ICD-10)

3D images

Compound

Description of the dosage form

Tablets: white or grayish-white in the form of a disc, beveled, with “SUPRASTIN” engraved on one side and a line on the other, odorless or almost odorless.

Solution: transparent, colorless aqueous, with a slight characteristic odor.

pharmachologic effect

Pharmacodynamics

Chloropyramine, a chlorinated analogue of tripelenamine (pyribenzamine), is a classic antihistamine that belongs to the group of ethylenediamine antihistamines.

H1 blocker , has antihistamine and m-anticholinergic effects, has an antiemetic effect, moderate antispasmodic and peripheral anticholinergic activity.

Pharmacokinetics

When taken orally, it is almost completely absorbed from the gastrointestinal tract. The therapeutic effect of chloropyramine develops within 15–30 minutes after oral administration, reaches a maximum within the first hour after administration and lasts at least 3–6 hours. It is well distributed in the body, including the central nervous system. Intensively metabolized in the liver. It is excreted mainly by the kidneys. In children, drug elimination occurs faster than in adult patients.

Indications of the drug Suprastin ®

seasonal and year-round allergic rhinitis;

acute and chronic eczema;

food and drug allergies;

allergic reactions to insect bites;

angioedema (Quincke's edema) - tablets, as an adjuvant.

Contraindications

hypersensitivity to the components of the drug;

acute attack of bronchial asthma;

children under 3 years of age (for this dosage form);

lactase deficiency, lactose intolerance, glucose/galactose malabsorption (since the tablet contains 116 mg of lactose monohydrate);

With caution: angle-closure glaucoma; urinary retention; prostatic hyperplasia; liver and/or kidney dysfunction; cardiovascular diseases; elderly patients.

Use during pregnancy and breastfeeding

There have been no adequate, well-controlled studies of the use of antihistamines in pregnant women. In accordance with this, Suprastin ® should be taken during pregnancy (especially in the first trimester and the last month) only if the potential benefit to the mother outweighs the possible risk to the fetus.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Side effects

Side effects, as a rule, occur extremely rarely, are temporary, and disappear after discontinuation of the drug.

From the blood and lymphatic system: very rarely - leukopenia, agranulocytosis, hemolytic anemia and other changes in the cellular composition of the blood.

From the central nervous system: drowsiness, fatigue, dizziness, nervous agitation, tremor, headache, euphoria, convulsions, encephalopathy.

From the organ of vision: blurred vision, glaucoma, increased intraocular pressure.

From the cardiovascular system: decreased blood pressure, tachycardia, arrhythmia. A direct connection between these side effects and the use of the drug has not always been established.

From the gastrointestinal tract: abdominal discomfort, dry mouth, nausea, vomiting, diarrhea, constipation, loss or increase of appetite, pain in the upper abdomen.

Musculoskeletal and connective tissue disorders: muscle weakness.

From the kidneys and urinary tract: difficulty urinating, urinary retention.

Other: photosensitivity, allergic reactions.

If any of the above effects occur, stop taking the drug and consult a doctor immediately.

Interaction

The drug enhances the effect of drugs: barbiturates, m-anticholinergics, opioid analgesics.

MAO inhibitors can enhance and prolong the anticholinergic effect of chloropyramine.

When combined with ototoxic drugs, Suprastin ® can mask early signs of ototoxicity.

Antihistamines can distort the results of skin allergy tests, so a few days before the planned test, you should stop taking drugs of this type.

Directions for use and doses

Orally, during meals, without chewing and with plenty of water.

Adults: prescribe 1 tablet. 3–4 times a day (75–100 mg/day).

Children: aged 3 to 6 years - 1/2 table. 2 times a day; from 6 to 14 years - 1/2 table. (12.5 mg) 2-3 times a day.

The dose can be gradually increased if the patient has no side effects, but the maximum dose should never exceed 2 mg/kg.

The duration of treatment depends on the symptoms of the disease, its duration and course.

Injection:

IM, IV (used only in acute severe cases under the supervision of a doctor!)

Adults: the recommended daily dose is 1–2 ml (1–2 amp.) IM.

Children: recommended initial doses - from 1 to 12 months - 0.25 ml (1/4 amp.) IM; from 1 to 6 years - 0.5 ml (1/2 amp.) IM; from 6 to 14 years - 0.5–1 ml (1/2–1 amp.) IM.

The dose may be increased cautiously depending on the patient's response and observed side effects. However, the dose should never exceed 2 mg/kg. In case of severe allergies, treatment should begin with a careful, slow intravenous injection, and then continue with intramuscular injections or oral administration of the drug.

Special groups of patients (general recommendations for both forms)

Elderly, debilitated patients: the use of the drug Suprastin ® requires special caution, because in these patients, antihistamines are more likely to cause side effects (dizziness, drowsiness).

Patients with impaired liver function: a dose reduction may be required due to a decrease in the metabolism of the active component of the drug in liver diseases.

Patients with impaired renal function: a change in the dosage regimen and a dose reduction may be required due to the fact that the active component is mainly excreted through the kidneys.

Overdose

Symptoms: hallucinations, anxiety, ataxia, incoordination, athetosis, convulsions. In young children - agitation, anxiety, dry mouth, fixed dilated pupils, facial flushing, sinus tachycardia, urinary retention, fever, coma.

In adults, fever and facial redness are observed intermittently, after a period of excitement followed by convulsions and post-convulsant depression, coma.

Treatment: up to 12 hours after taking the drug orally, gastric lavage is necessary (it should be taken into account that gastric emptying is prevented by the anticholinergic effect of the drug). The use of activated carbon is also indicated.

Monitoring of blood pressure and breathing parameters is necessary. Symptomatic therapy, resuscitation measures. A specific antidote is unknown.

special instructions

When combined with ototoxic drugs, Suprastin ® can mask early signs of ototoxicity.

Diseases of the liver and kidneys may require a change (reduction) in the dose of the drug, and therefore the patient should inform the doctor about the presence of liver or kidney disease. Taking the drug at night may increase the symptoms of reflux esophagitis.

Suprastin ® can enhance the effect of alcohol on the central nervous system, and therefore, while taking the drug Suprastin ® you should avoid drinking alcoholic beverages.

Long-term use of antihistamines can lead to disorders of the blood system and hematopoiesis (leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia). If during long-term use there is an unexplained increase in body temperature, laryngitis, pallor of the skin, jaundice, the formation of ulcers in the mouth, the appearance of hematomas, unusual and long-lasting bleeding, it is necessary to conduct a clinical blood test to determine the number of formed elements. If the test results indicate a change in the blood formula, stop taking the drug.

The influence of a medicinal product for medical use on the ability to drive vehicles and machinery. The drug, especially in the initial period of treatment, may cause drowsiness, fatigue and dizziness. Therefore, in the initial period, the duration of which is determined individually, driving vehicles or performing work associated with an increased risk of accidents is prohibited. After this, the degree of restriction on driving vehicles and operating machinery must be determined by the doctor individually for each patient.

Release form

Tablets, 25 mg. 20 tablets each in a brown glass bottle with a PE cap. 1 fl. in a cardboard box. 10 or 20 tablets each. in a blister; 2 blisters (10 pcs.) or 1 blister (20 pcs.) in a cardboard box.

Solution for intravenous and intramuscular administration, 20 mg/ml. Ampoules of 1 ml with a dark red code ring, 5 amps each. in a blister pack, 1 or 2 blister packs in a cardboard box.

Manufacturer

CJSC "EGIS Pharmaceutical Plant". 1106, Budapest, st. Keresturi, 30-38, Hungary.

Tel.: (36 1); fax: (36 1).

Consumer complaints should be sent to the following address: EGIS-RUS LLC, Moscow, st. Ivana Franko, 8.

Tel.: ; Fax: .

In the case of packaging and packing of the drug in Russia, the following is additionally indicated:

Packaged, packaged: SERDIKS LLC, Russia, Moscow region, Podolsk district, Sofiino village, p. 1/1.

Conditions for dispensing from pharmacies

Tablets - without a prescription.

Solution for injection - according to prescription.

Storage conditions for the drug Suprastin ®

Keep out of the reach of children.

Shelf life of the drug Suprastin ®

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

Prices in Moscow pharmacies

The information is intended solely for comparing prices in stationary pharmacies operating in accordance with Article 55 of the Federal Law “On the Circulation of Medicines” dated April 12, 2010 N 61-FZ.

tablets 25 mg, 20 pcs.

EGIS Pharmaceuticals PLC (Hungary)

tablets 25 mg, 20 pcs.

EGIS Pharmaceuticals PLC (Hungary)

tablets 25 mg, 20 pcs.

EGIS Pharmaceuticals PLC (Hungary)

tablets 25 mg, 20 pcs.

EGIS Pharmaceuticals PLC (Hungary)

solution for intravenous and intramuscular administration 20 mg/ml, 5 pcs.

EGIS Pharmaceuticals PLC (Hungary)

Reviews

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Opinion of “Doctors of the Russian Federation” about the drug Suprastin ®

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Suprastin

Description current as of 08/11/2015

  • Latin name: Suprastin
  • ATX code: R06AC03
  • Active ingredient: Chloropyramine
  • Manufacturer: EGIS Pharmaceuticals PLC (Hungary)

Compound

Suprastin tablets contain 25 mg of chloropyramine hydrochloride, gelatin, lactose monohydrate, stearic acid, sodium starch glycolate type A, potato starch, talc.

Suprastin in ampoules contains chloropyramine hydrochloride and water as an auxiliary component.

Release form

The medicine has 2 forms: tablets 25 mg and solution d/i 20 mg/ml.

Suprastin tablets are disc-shaped, grayish-white or white. The name “SUPRASTIN” is engraved on one side and a line on the other. The smell is weak or completely absent. The tablets are packaged in blisters of 10 pieces, 2 blisters in a package.

The aqueous solution is transparent and colorless, with a slight specific odor. Available in ampoules with a capacity of 1 ml, package No. 5.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

The active substance of Suprastin is a chlorinated analogue of tripelenamine and belongs to the group of 1st generation antihistamines, which - due to the main side effect - are also called sedatives.

The mechanism of action of chloropyramine is due to the ability of this substance to block histamine type H1 receptors. Studies (both preclinical and clinical) prove its effectiveness against hay fever and other allergic diseases.

Like other H1 blockers, the drug's action is aimed primarily at preventing immediate hypersensitivity reactions, and in cases where the reaction has already begun to develop, at preventing further histamine release.

Experiments on guinea pigs showed that even in a very low dosage, the drug protected animals from the effects of histamine at a dose 120 times higher than the lethal dose.

Chlorpyramin also affects the central nervous system, capillary permeability and smooth muscle.

Absorption from the digestive canal after taking the required dose is rapid. The effect is observed within minutes after taking the tablet, reaches its maximum within 1 hour and lasts for up to 6 hours.

Chlorpyramin is metabolized in the liver. Metabolic products are excreted mainly by the kidneys. Moreover, the drug is eliminated from the body of a child faster than from the body of an adult.

In patients with renal dysfunction, the elimination of chloropyramine may be reduced. With liver dysfunction, the metabolism of the substance slows down, which requires changing the dose of the drug.

Indications for use: what are Suprastin tablets and solution used for?

Suprastin tablets - what are they for?

Suprastin tablets are used in allergology:

The drug can also be prescribed to reduce swelling of the mucous membrane of the middle ear and nose during infections of the ENT organs (sinusitis, otitis media).

What does Suprastin in solution form help with?

Indications for the use of Suprastin in the form of a d/i solution are the same as for the tablet form of the drug.

Contraindications

Contraindications for Suprastin:

Side effects

Side effects of Suprastin from the central nervous system: increased fatigue, sedation, ataxia, dizziness, convulsions, tremor, headache, encephalopathy, decreased visual clarity, euphoria, drowsiness, impaired psychomotor functions.

From the cardiovascular system, arrhythmia, tachycardia, and arterial hypotension are possible. From the digestive system: discomfort and pain in the epigastrium, dry mouth, diarrhea, nausea, vomiting, increased symptoms of gastroesophageal reflux, increased or complete lack of appetite.

On the part of the blood system, in rare cases, pathological changes in the blood may be observed (for example, agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia, etc.).

From the urinary system and kidneys: urinary retention, dysuria.

From the subcutaneous tissue and skin: hypersensitivity reactions, as well as a painful reaction to sunlight.

From the musculoskeletal system: myopathy.

Reactions of the immune system to the use of the drug can be expressed in the form of skin itching, the appearance of a rash, skin hyperemia, urticaria, and angioedema.

Other side effects: changes at the injection site of the d/i ​​solution.

Instructions for use of Suprastin

Suprastin tablets: instructions for use. How to take Suprastin for adults?

The tablets should be taken with food, without crushing or chewing, and with liquid.

For adults, Suprastin tablets are prescribed to be taken daily. Exceed the dose of 100 mg/day. contraindicated.

Treatment is considered complete when all clinical symptoms are eliminated. If the above adverse reactions develop, the medication should be stopped.

How to take Suprastin if you have allergies if the disease is severe?

In acute severe conditions or anaphylactic shock, treatment begins with intravenous administration of the drug (intravenous injection should be performed very slowly). Subsequently, they switch to injecting the solution into the muscle or taking tablets.

The duration of use for severe allergies is determined by the attending physician.

Instructions for use of Suprastin in ampoules

Suprastin injections can only be given by a nurse or doctor.

The dosage of Suprastin for an adult is usually 1-2 ml/day. The drug is injected into the muscle. In especially severe cases, treatment begins with intravenous injections.

In case of liver dysfunction due to a decrease in the metabolism of the active substance, the patient may require a dose adjustment towards its reduction. A dose reduction is also necessary for patients with renal dysfunction, which is associated with the participation of this organ in removing chloropyramine from the body.

How many days should adults take Suprastin?

The duration of treatment depends on the severity of allergy symptoms and the body's sensitivity to chloropyramine. As a rule, the medicine is taken in short courses (5-7 days) when the process worsens. In case of severe disease, the doctor may make other prescriptions.

It should be remembered that with prolonged use of the drug, the patient may develop addiction to it.

Instructions for use of Suprastin for children

The use of Suprastin is also advisable for chickenpox: the drug can reduce the intensity of itching and somewhat calm the child’s nervous system.

Before giving Suprastin to children, you should read the list of contraindications. The use of tablets is contraindicated in children under 3 years of age; the solution is not prescribed to newborn infants (including premature infants).

In addition, you should not give the medicine in any form during an acute attack of asthma, intolerance to chloropyramine or any of the auxiliary components.

The manufacturer does not produce special children's Suprastin with a lower dosage of the active substance. There are no other dosage forms (ointment, drops, syrup) except tablets and solution.

How should children take Suprastin tablets?

Dosage of Suprastin for children under 6 years of age: 1 tablet/day, divided into 2 doses. According to the instructions, for children 6-14 years old the dose is 1-1.5 tablets/day. (0.5 tablets at each dose).

Depending on the body's response to treatment, the dose can be increased if necessary. The highest dose for a child is 2 mg/kg/day.

For infants, Suprastin tablets are prescribed, if necessary, 1/4-1/5 tablet. 2 rubles/day..

The solution, like the tablets, is dosed depending on the patient’s age: children under one year of age are administered 0.25 ml at the initial stages of treatment, children aged 12 months to 6 years - 0.5 ml, children aged 6- 14 years - from 0.5 to 1 ml.

Suprastin is contraindicated for newborns (including newborns born prematurely).

Injections are given with an insulin syringe with a needle for intramuscular injection. The maximum permissible dose of the drug is 2 mg/kg/day.

Overdose

Accidental or intentional overdose, especially in children, can cause death.

The symptoms and signs that occur with an overdose of Suprastin are similar to the symptoms of atropine poisoning. They are expressed in the form:

In young children, excitement predominates.

In some cases, sinus tachycardia, dry mouth, facial flushing, fixed dilated pupils, fever, and urinary retention occur.

In adults, facial flushing and fever are observed intermittently, with periods of agitation followed by convulsive seizures and postconvulsive depression. The patient develops coma, cardiac and respiratory failure. Death occurs within 2-18 hours.

Cardiorespiratory monitoring as well as symptomatic therapy are recommended. Suprastin does not have a specific antidote.

Interaction

Simultaneous use with MAO inhibitors helps to prolong and enhance the anticholinergic effects of Suprastin.

With caution, the medicine is prescribed with: tranquilizers, sedatives (including sedative analgesics), muscarinergic parasympatholytics, atropine, tricyclic antidepressants. This is due to the fact that in combination with Suprastin these drugs exhibit synergistic action.

Alcohol potentiates the inhibitory effect of chloropyramine on the central nervous system, and therefore, during treatment with Suprastin, drinking alcohol should be avoided.

Terms of sale

Suprastin in tablet form is available without a prescription; a prescription is required to purchase the solution.

Recipe in Latin for Suprastin tablets for allergies:

Rр.: Tab.Suprastini 0.025 No. 20

DS For oral administration (1 tablet 2-3 times a day with meals)

Storage conditions

The medicine retains its pharmacological properties at a temperature of 15-25°C. Both tablets and ampoules should be kept away from children.

Best before date

special instructions

The annotation states that the drug should be used with caution in elderly people, as well as in patients with heart pathologies and liver failure.

If taken in the evening, the drug may increase the symptoms of gastroesophageal reflux.

It should be remembered that chloropyramine can cause depression and drowsiness, interfering with certain types of activity. They are especially pronounced at the initial stages of treatment.

The doctor determines the degree of restriction on working with machinery and driving vehicles individually for each patient.

Application in veterinary medicine

Chlorpyramin can be used for drug therapy of allergic conditions in animals.

It is given orally 2-3 times a day. at a dose of 0.3-0.5 mg/kg. When administered intramuscularly, the dose for horses is ml, for pigs weighing kgml, for dogs the dosage depending on weight is from 0.1 to 0.5 ml. Injections are given 2 times a day.

Suprastin's analogs

Pharmaceutical equivalents of the drug are Chlorpyramin, Chlorpyramin-Ferein, Chlorpyramin-Eskom.

The price of analogues in tablets is rubles. 10 ampoules of the solution will cost approximately the same amount.

Which is better - Suprastin or Tavegil?

Both products are 1st generation drugs. The duration of the effect produced and the intensity of action are comparable.

Which is better - Cetrin or Suprastin?

Cetrin (cetirizine hydrochloride) is a 2nd generation drug that is a highly selective antagonist of H1-type histamine receptors.

The drug has 2 release forms - tablets, which are used in patients over 6 years of age, and syrup, which is prescribed from 2 years of age.

Cetirizine hydrochloride is practically not biotransformed in the body; the rate of its elimination is related to the functional state of the kidneys. A special feature of the drug is its ability to penetrate well into the skin, which makes Cetrin especially effective for skin manifestations of allergies.

The drug does not have a proarrhythmic effect, which has been proven in preclinical and clinical studies.

This means that the use of Cetrin is much less likely to be accompanied by the development of adverse reactions than the use of 1st generation products. Moreover, the degree of expression of the latter is also less than that of Suprastin.

If we talk about antiallergic activity, then Suprastin is considered a somewhat stronger remedy.

Which is better: Zyrtec or Suprastin?

Zirtec is a generic version of Cetrin, since both of these drugs contain the same substance - cetirizine. Thus, Zirtec has the same advantages over Suprastin as Cetrin.

Which is better - Suprastin or Diazolin?

The active substance of Diazolin is a blocker of histamine receptors of subtype 1, mebhydrolin, like chloropyramine, belongs to the 1st generation drugs. In comparison with its analogue, the product is characterized by less antiallergic activity. The sedative effect is slightly pronounced.

Suprastin or Zodak - which is better?

Zodak is a 2nd generation antiallergic drug with prolonged action. Its basis is cetirizine dihydrochloride, a substance characterized by the ability to selectively block peripheral H1-type histamine receptors.

It does not have a pronounced anticholinergic and antiserotonin effect. There is no sedation (including drowsiness) when used in therapeutic doses.

Which is better: Loratadine or Suprastin?

Loratadine is a 2nd generation antihistamine, which is characterized by high binding strength to peripheral H1-type histamine receptors. It has no sedative effect, does not have cardiotoxic effects and does not enhance the effects of alcohol.

Loratadine practically does not interact with other medications.

Which is better: Suprastin or Claritin?

Since the active ingredient of the drug Claritin is loratadine, the choice between it and Suprastin should be made taking into account the features described above.

Alcohol and Suprastin

The drug is incompatible with alcohol.

What is Suprastin? This is a first generation antiallergic drug. Like other drugs from this group, it has a pronounced anticholinergic, hypnotic and sedative effect, which is enhanced in combination with alcohol.

Suprastin and alcohol: consequences of simultaneous use

Drinking alcohol during treatment with Suprastin can provoke symptoms such as:

Suprastin during pregnancy and breastfeeding

Can pregnant women take Suprastin?

There are no data from preclinical studies on the use of the drug during pregnancy.

Adequate studies with proper control of the use of the drug in pregnant women have also not been conducted. However, there is evidence that newborn babies whose mothers took antihistamines during the last 2 weeks of pregnancy developed connective tissue behind the lens of the eye.

In the description of the drug, the manufacturer warns that the use of Suprastin - especially in the 1st trimester and in the last weeks of the 3rd trimester - is possible only after a careful assessment of the beneficial effects and possible risks.

As for use in the 2nd trimester, the drug is also prescribed during this period after the risks to the fetus and the benefits to the mother’s body have been analyzed.

Thus, the question of whether Suprastin can be taken during pregnancy can only be answered by a doctor monitoring a pregnant woman.

Suprastin during lactation: can nursing mothers take antihistamines?

In the absence of well-controlled, adequate data on the use of the drug in breastfeeding, it is not recommended for use in breastfeeding women.

Reviews about Suprastin

Reviews of Suprastin for children and adults prove the high antihistamine activity of this drug. The product is effective for the treatment of allergic rhinoconjunctivitis (both year-round and seasonal), urticaria, Quincke's edema, eczema, atopic dermatitis, itching of various etiologies.

In parenteral form, the drug has proven itself well in conditions that require emergency care.

The advantages of the drug are proven effectiveness, a wide range of therapeutic doses used, speed of action, short duration of side effects, controllability of the clinical effect, low cost. The active substance of the drug does not accumulate in the serum, which eliminates the possibility of overdose with long-term use.

Wikipedia indicates that Suprastin is included in the Russian list of vital and essential drugs.

How much do Suprastin tablets and injections cost?

The price of Suprastin tablets in Russia is from 110 rubles. The price of Suprastin in ampoules is from 150 rubles.

The average price in Ukraine for tablets 25 mg No. UAH, the price of Suprastin 25 mg No. 10 is from 29 UAH. The d/i ​​solution can be purchased in pharmacies in Kharkov and Kyiv. At the same time, the cost of 1 ampoule is UAH.

For patients who are more comfortable using drops, Egis has developed the drug Suprastinex based on levocetirizine. Its cost is from 1060 rubles. in Russian, and from 350 UAH in Ukrainian pharmacies.

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Inna: Usually, insomnia occurs for me due to some kind of experience and when you lie down, it’s not.

Olesya: I tried glycine forte, which is more expensive in the price category, but the dosage is the same.

Andrey: Not a word is said about choosing the size of stockings according to a person’s parameters: height, leg size, etc.

Olga: For coxarthrosis of the 2nd degree, I have been injecting for 4 years at the rate (after 6 months), there is no improvement.

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Source: http://medside.ru/suprastin