Suprax annotation

Pharmacological action (effect)

Semisynthetic cephalosporin antibiotic of the third generation for oral administration with a broad spectrum of action. Acts bactericidal. The mechanism of action is due to inhibition of the synthesis of the pathogen's cell membrane. Cefixime is resistant to the action of β-lactamases produced by most gram-positive and gram-negative bacteria.

In vitro, cefixime is active against gram-positive bacteria: Streptococcus agalactiae; gram-negative bacteria: Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter amalonaticus, Citrobacter diversus, Serratia marcescens.

In vitro and in clinical practice, cefixime is active against gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes; gram-negative bacteria: Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae.

Pseudomonas spp., Enterococcus (Streptococcus) serogroup D, Listeria monocytogenes, most Staphylococcus spp. are resistant to the drug (including methicillin-resistant strains), Enterobacter spp., Bacteroides fragilis, Clostridium spp.

Pharmacokinetics (action in the body)

Suction and distribution

When taken (consumed) orally, the bioavailability (digestibility) of cefixime is 40-50%, regardless of food intake, however, the Cmax _of cefixime in serum is achieved (obtained) faster by 0.8 hour when taking (using) the drug with food.

When taking (using) the drug in the form of capsules at a dose of 200 mg, Cmax _in the blood serum is reached (obtained) after 4 hours and is 2 mcg (micrograms)/ml, when taking (using) at a dose of 400 mg - 3.5 mcg (microgram)/ml.

Binding to plasma proteins, mainly albumin, is 65%.

About 50% of the dose (dose) is excreted in the urine unchanged (form) within 24 hours, about 10% of the dose (dose) is excreted in the bile.

T _1/2 depends on the dose (dosage) and is 3-4 hours.

Pharmacokinetics (action in the body) in special clinical cases

In patients (patients) with impaired renal function (lat. renes) with CC from 20 to 40 ml (milliliters)/min T1 _/2 increases to 6.4 hours, with CC 5-10 ml (milliliters)/min - up to 11.5 hours .

Indications (use recommended)

Infectious and inflammatory diseases (lesions) caused by microorganisms sensitive to the drug:

- acute and chronic bronchitis;

— uncomplicated infections (infections) of the urinary tract;

- gonococcal infection of the urethra and cervix.

Dosing regimen (rules)

For adults and children over 12 years of age with a body weight of more than 50 kg, the daily (for one day) dose is 400 mg (1 time/day (day) or 200 mg 2 times/day (day)). The duration of the course of treatment (healing) is days (days).

For uncomplicated gonorrhea of ​​the urethra and cervix, 400 mg is prescribed once.

For children under the age of 12 years, the drug is prescribed in the form of a suspension at a dose of 8 mg/kg body weight (m) 1 time/day or 4 mg/kg every 12 hours.

For children aged 5-11 years, the daily (for one day) dose is 6-10 ml (milliliters) of suspension, at the age of 2-4 years - 5 ml (milliliters), at the age of 6 months to 1 year - 2.5-4 ml (milliliters).

For infections caused by Streptococcus pyogenes, the course of treatment (healing) should be at least 10 days (days).

In case of impaired renal function (lat. renes) (with CC from 21 to 60 ml (milliliters)/min) or in patients (patients) on hemodialysis, the daily dose should be reduced by 25%.

With CC≤20 ml (milliliters)/min or in patients (patients) on peritoneal dialysis, the daily dose should be reduced by 2 times.

Rules for preparing the suspension

Turn the bottle (vial) over and shake the granules. Add 40 ml (milliliters) of boiled water cooled to room temperature (t°) in 2 stages and shake after each addition until a homogeneous suspension is formed. After this, it is necessary (required) to let the suspension stand for (for) 5 minutes to ensure complete disintegration of the granules. Before (before) use, the finished suspension should be shaken.

Side effect (effect)

From the digestive system: dry mouth, anorexia, diarrhea (diarrhea), nausea (vomiting), vomiting (when you feel sick), abdominal pain, flatulence (excessive accumulation of gases in the intestines), transient increase (growth) in the activity of liver transaminases ( aminotransferases) and alkaline phosphatase (alkaline phosphatase), hyperbilirubinemia, jaundice (icterus), gastrointestinal candidiasis (gastrointestinal tract), dysbacteriosis; rarely (infrequently) - stomatitis, glossitis, pseudomembranous enterocolitis.

From the hematopoietic system (blood renewal): leukopenia (decrease in the absolute content of leukocytes in the peripheral blood), thrombocytopenia (decrease in the number of platelets in the peripheral blood), neutropenia, hemolytic anemia (anemia).

From the central nervous system (central nervous system): dizziness (vertigo), headache (in the head).

From the urinary system: interstitial nephritis.

Allergic (allergy - hypersensitivity of the body's immune system, with repeated exposure to an allergen on an organism previously sensitized by this allergen) reactions: skin itching, urticaria (urticaria), skin hyperemia, eosinophilia, fever.

Contraindications (use not recommended)

- increased (increased) sensitivity to cephalosporins and penicillins.

with caution to elderly patients (patients), patients (patients) with chronic renal (kidney) failure or pseudomembranous colitis (history), children under 6 months of age.

Pregnancy (gestation) and lactation (breastfeeding)

The use of Suprax during pregnancy (gestation) is possible only if the expected benefit to the mother outweighs the potential risk to the fetus (embryo).

If it is necessary (necessary) to use Suprax during the period (term) of lactation, you should stop (stop) breastfeeding.

Special (special) instructions

With long-term use of the drug, it is possible (acceptable) to disrupt the normal (ordinary) intestinal microflora, which can lead to the growth of Clostridium difficile and cause the development of severe diarrhea and pseudomembranous colitis.

Patients with a history of allergic reactions to penicillins may exhibit increased sensitivity to cephalosporin antibiotics.

During (t) treatment, a positive direct Coombs test and a false positive urine test for glucose are possible.

Overdose (exceeding the safe dosage)

Symptoms: increased manifestations of the described side effects.

Treatment (therapy): gastric lavage; carry out symptomatic and supportive therapy (treatment), which, if necessary (need), includes the use of antihistamines (medicines), glucocorticoids, pressor amines, oxygen therapy, transfusion of infusion solutions, mechanical ventilation.

Hemodialysis and peritoneal dialysis are ineffective.

Drug interactions

Blockers of tubular secretion (allopurinol, diuretics (diuretics)) delay the excretion (excretion) of cefixime by the kidneys, which can lead to increased toxicity (poisonousness).

Cefixime reduces the prothrombin index, enhances the action (effect) of indirect anticoagulants (against blood clotting).

Antacids containing magnesium (Mg) or aluminum (Al) hydroxide slow down the absorption of cefixime.

Conditions and terms (time) of storage

List (list) B. The drug should be stored (kept) out of the reach of children at a temperature (t°) of 15° to 25°C. Shelf life (storage) - 3 years.

The prepared suspension should be used within 14 days (days) from the moment of preparation, subject to storage conditions (15-25°C).

Conditions for dispensing from pharmacies

Making an appointment with a doctor via the Internet, © SAMSON Group LLC18

Call an ambulance.

The minimum cost of the service is 4'500 rubles. When ordering from the OnLineLPU portal, a 5% discount.

Source: http://onlinelpu.ru/drugs/%D0%A1%D1%83%D0%BF%D1%80%D0%B0%D0%BA%D1%81

SUPRAX

Semisynthetic cephalosporin antibiotic of the third generation for oral administration with a broad spectrum of action. Acts bactericidal. The mechanism of action is due to inhibition of the synthesis of the pathogen's cell membrane. Cefixime is resistant to the action of β-lactamases produced by most gram-positive and gram-negative bacteria.

In vitro, cefixime is active against gram-positive bacteria: Streptococcus agalactiae; gram-negative bacteria: Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter amalonaticus, Citrobacter diversus, Serratia marcescens.

In vitro and in clinical practice, cefixime is active against gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes; gram-negative bacteria: Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae.

Pseudomonas spp., Enterococcus (Streptococcus) serogroup D, Listeria monocytogenes, most Staphylococcus spp. are resistant to cefixime (including methicillin-resistant strains), Enterobacter spp., Bacteroides fragilis, Clostridium spp.

When taken orally, the bioavailability of cefixime is 40-50%, regardless of food intake, however, the Cmax _of cefixime in serum is achieved faster by 0.8 hours when taking the drug with food. Binding to plasma proteins, mainly albumin, is 65%. About 50% of the dose is excreted unchanged in the urine within 24 hours, about 10% of the dose is excreted in the bile. T1 _/2 depends on the dose and is 3-4 hours. In patients with impaired renal function with CC from 20 to 40 ml/min, T1 _/2 increases to 6.4 hours, with CC 5-10 ml/min - up to 11.5 hours .

Infectious and inflammatory diseases caused by sensitive microorganisms: pharyngitis, tonsillitis, sinusitis, acute and chronic bronchitis, otitis media, uncomplicated urinary tract infections, uncomplicated gonorrhea.

Hypersensitivity to cephalosporins and penicillins.

For adults and children over 12 years of age weighing more than 50 kg, the daily dose is 400 mg (1 time/day or 200 mg 2 times/day). Duration of treatment: days. For uncomplicated gonorrhea, once.

Children under 12 years of age - 8 mg/kg body weight 1 time/day or 4 mg/kg every 12 hours.

For infections caused by Streptococcus pyogenes, the course of treatment should be at least 10 days.

In case of impaired renal function (with CC from 21 to 60 ml/min) or in patients on hemodialysis, the daily dose should be reduced by 25%.

With CC≤20 ml/min or in patients on peritoneal dialysis, the daily dose should be reduced by 2 times.

From the digestive system: dry mouth, anorexia, diarrhea, nausea, vomiting, abdominal pain, flatulence, transient increase in the activity of liver transaminases and alkaline phosphatase, hyperbilirubinemia, jaundice, gastrointestinal candidiasis, dysbacteriosis; rarely - stomatitis, glossitis, pseudomembranous enterocolitis.

From the hematopoietic system: leukopenia, thrombocytopenia, neutropenia, hemolytic anemia.

From the side of the central nervous system: dizziness, headache.

From the urinary system: interstitial nephritis.

Allergic reactions: skin itching, urticaria, skin hyperemia, eosinophilia, fever.

Blockers of tubular secretion (allopurinol, diuretics) delay the excretion of cefixime by the kidneys, which can lead to increased toxicity.

Cefixime reduces the prothrombin index and enhances the effect of indirect anticoagulants.

Antacids containing magnesium or aluminum hydroxide slow down the absorption of cefixime.

Use with caution in elderly patients, patients with chronic renal failure or pseudomembranous colitis (history), and in children under 6 months of age.

With long-term use, normal intestinal microflora may be disrupted, which can lead to the growth of Clostridium difficile and cause the development of severe diarrhea and pseudomembranous colitis.

In patients with a history of allergic reactions to penicillins, manifestations of hypersensitivity to cephalosporin antibiotics are possible.

During treatment, a positive direct Coombs test and a false positive urine test for glucose are possible.

Use during pregnancy is possible only when the expected benefit to the mother outweighs the potential risk to the fetus.

If necessary, use during lactation should stop breastfeeding.

In case of impaired renal function (with CC from 21 to 60 ml/min) or in patients on hemodialysis, the daily dose should be reduced by 25%. With CC≤20 ml/min, the daily dose should be reduced by 2 times.

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Source: http://health.mail.ru/drug/suprax/

Suprax suspension: instructions for use for children and adults

• Uncomplicated lesions of the ear, mastoid process: otitis media, mastoiditis.

• Not severe acute, chronic bronchitis.

• Uncomplicated gonorrhea.

• Not severe infections of the urinary tract, kidneys: pyelonephritis, cystitis, urethritis.

• Allergic reactions: rash, urticaria, anaphylactic shock, Quincke's edema, skin itching, transient increase in body temperature, eosinophilia (increase in eosinophils in the blood).

• Hematopoietic organs: decreased levels of leukocytes, neutrophils, platelets, hemolytic anemia.

• Urinary system: interstitial nephritis.

• Nervous system: dizziness, headaches.

Source: http://www.rasteniya-lecarstvennie.ru/3113-supraks-suspenziya-instrukciya-po-primeneniyu-dlya-detey-i-vzroslyh.html

Antibiotic Suprax: instructions for use, dosages for children and adults

Suprax is an antibacterial agent available in various forms. This is a 3rd generation semisynthetic cephalosporin antibiotic. Inhibits the synthesis of the cell membrane and is resistant to the action of lactamases, which are produced by most bacteria.

Composition, release form, packaging

The 200 mg capsules with a yellow cap and former body contain a mixture of granules and powder. The 400 mg capsules have a purple cap and a white body. The latter is marked with the code H808.

Excipients are: silicon dioxide, magnesium, azorubine and carboxymethylcellulose. The shell is made of titanium dioxide, dyes and gelatin. One cardboard package contains 6 capsules placed in a cellular contour packaging.

Granules for preparing a suspension contain 100 mg of active substance. Excipients are sodium benzonate, sucrose, flavoring, yellow gum. Granules for preparing a suspension are produced in 60 ml dark glass bottles.

A dosing spoon is included. After dilution, the suspension is almost white in color with a sweet strawberry flavor. In all forms, the main antibacterial substance is cefixime.

Manufacturer

The antibiotic is produced in Jordan by GEDEON RICHTER

Indications for use

Suprax is prescribed for diseases caused by bacterial infection. With its help you can effectively treat:

Contraindications

The main group of contraindications includes increased sensitivity of the body to drugs of the cephalosporin and penicillin group. It is prescribed with special caution to babies under 6 months, elderly citizens, people with pseudomembranous colitis and renal failure. Contraindications for capsules are children under 12 years of age.

Mechanism of action

Suprax is the first antibiotic of the 3rd generation tsifalosporin group, which is used for internal use. The bactericidal mechanism is realized by inhibiting the formation of the walls of pathogens.

Unlike other similar drugs, Suprax is resistant to bacterial enzymes that destroy the antibiotic.

The bioavailability of the antibiotic is about 50%. Food does not reduce this indicator, but it lengthens the time to reach the maximum amount in biological fluids by several units. Among other similar drugs, this medicine has a long half-life. Thanks to this, it is taken once a day. This is very convenient when treating children.

The medicine penetrates well into the site of infection - the middle ear, tonsils, and sinuses. 50% of the unchanged drug is excreted in the urine. Therefore, Suprax can be used to treat urinary tract infections. 10% is excreted in bile.

Instructions for use

They are indicated for persons weighing more than 50 kg and over 12 years of age. Prescribed 400 mg once a day. For gonorrhea that occurs without complications, 400 mg is prescribed 1 time. The duration of taking the drug is 7-10 days. For infectious lesions, the course should be at least 10 days. For patients with impaired renal function with creatinine clearance less than 60 ml/min, the drug is prescribed in the form of a suspension.

For children under 12 years of age, the dose is selected depending on weight: 8 mg/kg once a day or 4 mg/kg every 12 hours. Children from 5-12 years old can drink no more than 10 ml per day, from 2-4 years old - 5 ml, up to a year - 4 ml. The average duration is 7-10 days.

Abstract on the use of Suprax:

Side effects

Reactions from other systems are also possible: headache, tinnitus, vaginitis, dysfunction of the urinary system, nausea, dysbacteriosis, jaundice, anemia, thrombocytopenia. Laboratory parameters indicate an increase in the activity of liver transaminases, an increase in urea nitrogen, and an increase in prothrombin time.

Other side effects include the development of hypovitaminosis B, the appearance of shortness of breath and candidiasis.

Overdose

As the dose increases, side effects may increase, especially from the gastrointestinal tract. Treatment is carried out by washing and maintenance therapy. It must be taken into account that peritoneal dialysis and hemodialysis are ineffective.

If necessary, antihistamines, glucocorticoids, pressor amines and transfusion of infusion solutions can be prescribed.

special instructions

Capsules and suspension should only be used when the intended benefit to the mother is greater than the risk to the fetus. It is recommended to interrupt breastfeeding while taking the medication.

Drug interactions

Allopurinol and diuretics delay the excretion of cefixime by the kidneys. This increases the toxicity of the drug. Suprax reduces the prothrombin index and leads to increased action of indirect anticoagulants. Drugs that contain magnesium and aluminum hydroxide can slow down the absorption process of the drug.

If kidney function is impaired or in people on hemodialysis, the daily dose is reduced by 25%.

Reviews about the drug

According to reviews, the drug is prescribed for various bacterial infections and enlarged lymph nodes. It is most often prescribed to be taken once a day, but for children it is recommended to split the dose into two doses.

Prices for Suprax

Current prices in Moscow start from 499 rubles. The medicine is available in almost all pharmacies. Capsules will cost more. Their cost starts from 620 rubles. The maximum threshold is 1240 rubles.

Analogs

• Tsedex,
• Suprax-solutab.

Cheap

Structural low-cost analogues:

Drug synonyms

• Sumamed,
• Klacid,
• Amoxiclav,
• Ceftriaskon.

Read more about drug analogues in our video:

Conditions for dispensing from pharmacies

Dispensed by prescription.

Storage conditions and shelf life

Suprax is stored at a temperature of degrees. Shelf life: 3 years. The finished suspension can be stored for no more than 14 days.

Source: http://gidmed.com/otorinolarintologija/lekarstva-lor/supraks.html

SUPRAX

Active substance: cefixime

ATX code: J01DD08

CFG: III generation cephalosporin

Reg. number: P No. 013023/02

Registration date: 04/11/07

Owner reg. credential: HIKMA PHARMACEUTICALS

DOSAGE FORM, COMPOSITION AND PACKAGING

Capsules with a yellow cap and a white body; the contents of the capsules are a yellowish-white mixture of powder and small granules.

Excipients: colloidal silicon dioxide, magnesium stearate, carboxymethylcellulose.

Composition of the capsule shell: titanium dioxide, D&C yellow dye 10, FD&C yellow dye 6, gelatin.

6 pcs. - blisters (1) - cardboard packs.

Capsules with a purple cap and a white body, with the code “H808” printed on them; the contents of the capsules are a yellowish-white mixture of powder and small granules.

Excipients: colloidal silicon dioxide, magnesium stearate, carboxymethylcellulose.

Composition of the capsule shell: titanium dioxide, D&C yellow dye 10, FD&C yellow dye 6, D&C red dye 33, FD&C blue dye 1, gelatin.

6 pcs. - blisters (1) - cardboard packs.

Granules for the preparation of oral suspension from almost white to cream color; The finished suspension is almost white to cream in color with a sweet strawberry aroma.

Excipients: sodium benzoate, sucrose, yellow gum, strawberry flavor.

Dark glass bottles with a volume of 60 ml (1) complete with a dosing spoon - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

Semi-synthetic broad-spectrum cephalosporin antibiotic of the third generation for oral administration. Acts bactericidal. The mechanism of action is due to inhibition of the synthesis of the pathogen's cell membrane. Cefixime is resistant to the action of β-lactamases produced by most gram-positive and gram-negative bacteria.

In vitro, cefixime is active against gram-positive bacteria: Streptococcus agalactiae; gram-negative bacteria: Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter amalonaticus, Citrobacter diversus, Serratia marcescens.

In vitro and in clinical practice, cefixime is active against gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes; gram-negative bacteria: Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae.

Pseudomonas spp., Enterococcus (Streptococcus) serogroup D, Listeria monocytogenes, most Staphylococcus spp. are resistant to the drug. (including methicillin-resistant strains), Enterobacter spp., Bacteroides fragilis, Clostridium spp.

Suction and distribution

When taken orally, the bioavailability of cefixime is 40-50%, regardless of food intake, however, the Cmax _of cefixime in serum is achieved faster by 0.8 hours when taking the drug with food.

When taking the drug in capsule form at a dose of 200 mg, _Cmax in the blood serum is reached after 4 hours and is 2 μg/ml, when taken at a dose of 400 mg - 3.5 μg/ml.

When taking the drug in the form of a suspension at a dose of 200 mg, Cmax _in the blood serum is reached after 4 hours and is 2.8 μg/ml, when taken at a dose of 400 mg - 4.4 μg/ml.

Binding to plasma proteins, mainly albumin, is 65%.

About 50% of the dose is excreted unchanged in the urine within 24 hours, about 10% of the dose is excreted in bile.

T1 _/2 depends on the dose and is 3-4 hours.

Pharmacokinetics in special clinical situations

In patients with impaired renal function with CC from 20 to 40 ml/min, T1 _/2 increases to 6.4 hours, with CC 5-10 ml/min - up to 11.5 hours.

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

- acute and chronic bronchitis;

- uncomplicated urinary tract infections;

For adults and children over 12 years of age weighing more than 50 kg, the daily dose is 400 mg (1 time/day or 200 mg 2 times/day). Duration of treatment: days.

For uncomplicated gonorrhea, 400 mg is prescribed once.

For children under 12 years of age, the drug is prescribed as a suspension at a dose of 8 mg/kg body weight 1 time/day or 4 mg/kg every 12 hours.

For children aged 5-11 years, the daily dose is 6-10 ml of suspension, for children aged 2-4 years - 5 ml, for children aged from 6 months to 1 year - 2.5-4 ml.

For infections caused by Streptococcus pyogenes, the course of treatment should be at least 10 days.

In case of impaired renal function (with CC from 21 to 60 ml/min) or in patients on hemodialysis, the daily dose should be reduced by 25%.

With CC ≥20 ml/min or in patients on peritoneal dialysis, the daily dose should be reduced by 2 times.

Rules for preparing the suspension

Turn the bottle over and shake the granules. Add 40 ml of boiled water cooled to room temperature in 2 stages and shake after each addition until a homogeneous suspension is formed. After this, it is necessary to allow the suspension to stand for 5 minutes to ensure complete disintegration of the granules. The prepared suspension should be shaken before use.

From the digestive system: dry mouth, anorexia, diarrhea, nausea, vomiting, abdominal pain, flatulence, transient increase in the activity of liver transaminases and alkaline phosphatase, hyperbilirubinemia, jaundice, gastrointestinal candidiasis, dysbacteriosis; rarely - stomatitis, glossitis, pseudomembranous enterocolitis.

From the hematopoietic system: leukopenia, thrombocytopenia, neutropenia, hemolytic anemia.

From the side of the central nervous system: dizziness, headache.

From the urinary system: interstitial nephritis.

Allergic reactions: skin itching, urticaria, skin hyperemia, eosinophilia, fever.

- hypersensitivity to cephalosporins and penicillins.

Suprax should be prescribed with caution to elderly patients, patients with chronic renal failure or pseudomembranous colitis (history), and children under 6 months of age.

The use of Suprax during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to use Suprax during lactation, breastfeeding should be stopped.

Long-term use of the drug may disrupt the normal intestinal microflora, which can lead to the growth of Clostridium difficile and cause the development of severe diarrhea and pseudomembranous colitis.

Patients with a history of allergic reactions to penicillins may exhibit increased sensitivity to cephalosporin antibiotics.

During treatment, a positive direct Coombs test and a false positive urine test for glucose are possible.

Symptoms: increased manifestations of the described side effects.

Treatment: gastric lavage; carry out symptomatic and supportive therapy, which, if necessary, includes the use of antihistamines, corticosteroids, pressor amines, oxygen therapy, transfusion of infusion solutions, mechanical ventilation. Hemodialysis and peritoneal dialysis are ineffective.

Blockers of tubular secretion (allopurinol, diuretics) delay the excretion of cefixime by the kidneys, which can lead to increased toxicity.

Cefixime reduces the prothrombin index and enhances the effect of indirect anticoagulants.

Antacids containing magnesium or aluminum hydroxide slow down the absorption of cefixime.

The drug is available with a prescription.

List B. The drug should be stored out of the reach of children at a temperature of 15° to 25°C. Shelf life: 3 years.

The prepared suspension should be used within 14 days from the date of preparation, subject to storage conditions (15-25°C).

Source: http://docvita.ru/Details/SUPRAX.html

Suprax ® (Suprax)

Active substance:

Content

Pharmacological group

Nosological classification (ICD-10)

3D images

Composition and release form

in a blister pack 6 pcs.; in a cardboard pack 1 package.

in dark glass bottles of 60 ml; in a cardboard pack 1 bottle complete with a dosing spoon.

Description of the dosage form

200 mg capsules with a yellow cap and a white body, containing a mixture of powder and small granules of a yellowish-white color.

400 mg capsules with a purple cap and a white body, containing a mixture of powder and small granules of a yellowish-white color. The code H808 is marked on the capsule.

Granules for the preparation of suspension for oral administration: small granules from white to cream color. After dilution, the suspension is almost white to cream in color with a sweet strawberry aroma.

Characteristic

Semisynthetic cephalosporin antibiotic of the third generation for oral administration.

pharmachologic effect

Pharmacodynamics

Inhibits the synthesis of the pathogen's cell membrane. Cefixime is resistant to beta-lactamases produced by most gram-positive and gram-negative bacteria.

In vitro, cefixime is active against gram-positive bacteria: Streptococcus agalactiae; gram-negative bacteria: Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter amalonaticus, Citrobacter diversus, Serratia marcescens.

In vitro and in clinical practice, cefixime is active against gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes; gram-negative bacteria: Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, E.coli, Proteus mirabilis, Neisseria gonorrhoeae.

Pseudomonas spp., Enterococcus (Streptococcus) serogroup D, Listeria monocytogenes, most Staphylococcus spp. are resistant to the drug. (including methicillin-resistant strains), Enterobacter spp., Bacteroides fragilis, Clostridium spp.

Pharmacokinetics

When taken orally, the bioavailability of cefixime is 40–50%, regardless of food intake, however, the Cmax _of cefixime in serum is achieved 0.8 hours faster when taking the drug with food.

When taking the drug in capsule form at a dose of 200 mg, _Cmax in serum is achieved after 4 hours and is 2 μg/ml, when taken at a dose of 400 mg - 3.5 μg/ml. When taking the drug in the form of a suspension at a dose of 200 mg, _Cmax in serum is achieved after 4 hours and is 2.8 μg/ml, when taken at a dose of 400 mg - 4.4 μg/ml. Binding to plasma proteins, mainly albumin, is 65%.

About 50% of the dose is excreted unchanged in the urine within 24 hours, about 10% of the dose is excreted in bile. T1 _/2 depends on the dose and is 3–4 hours.

In patients with impaired renal function, with a creatinine Cl of 20-40 ml/min, T1 _/2 increases to 6.4 hours, with a creatinine Cl of 5-10 ml/min - up to 11.5 hours.

Indications of the drug Suprax ®

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

pharyngitis, tonsillitis, sinusitis;

acute and chronic bronchitis;

uncomplicated urinary tract infections;

Contraindications

Hypersensitivity to cephalosporins and penicillins.

chronic renal failure;

pseudomembranous colitis (history);

children's age (up to 6 months).

Use during pregnancy and breastfeeding

Use during pregnancy is possible only when the expected benefit to the mother outweighs the potential risk to the fetus.

If necessary, use during lactation should stop breastfeeding.

Side effects

Allergic reactions: urticaria, skin hyperemia, itching, eosinophilia, fever.

From the digestive system: dry mouth, anorexia, nausea, vomiting, diarrhea, flatulence, abdominal pain, dysbiosis, liver dysfunction (increased activity of liver transaminases, alkaline phosphatase, hyperbilirubinemia, jaundice), gastrointestinal candidiasis; rarely - stomatitis, glossitis, pseudomembranous enterocolitis.

From the hematopoietic organs: leukopenia, neutropenia, thrombocytopenia, hemolytic anemia.

From the urinary system: interstitial nephritis.

From the nervous system: dizziness, headache.

Interaction

Blockers of tubular secretion (allopurinol, diuretics, etc.) delay the excretion of cefixime by the kidneys, which can lead to increased toxicity.

Reduces the prothrombin index, enhances the effect of indirect anticoagulants.

Antacids containing magnesium or aluminum hydroxide slow down the absorption of the drug.

Directions for use and doses

Inside. For adults and children over 12 years of age weighing more than 50 kg, the average daily dose is 400 mg (once a day or 200 mg 2 times a day). The average duration of treatment is 7–10 days.

For uncomplicated gonorrhea - 400 mg once a day.

Children under 12 years of age are prescribed as a suspension at a dose of 8 mg/kg once or in 2 doses (4 mg/kg every 12 hours). For children aged 6 months to 1 year, the daily dose of the suspension is 2.5-4 ml, for children aged 2-4 years - 5 ml, for children aged 5-11 years - 6-10 ml. For diseases caused by Streptococcus pyogenes, the course of treatment is at least 10 days.

In case of impaired renal function, the dose is set depending on the serum creatinine clearance: with creatinine Cl 21–60 ml/min or in patients on hemodialysis, the daily dose should be reduced by 25%. When Cl creatinine is less than or equal to 20 ml/min or in patients on peritoneal dialysis, the daily dose should be reduced by 2 times.

Method for preparing the suspension: turn the bottle over and shake the powder. Add 40 ml of boiled water cooled to room temperature in 2 stages and shake after each addition until a homogeneous suspension is formed. After this, it is necessary to allow the suspension to stand for 5 minutes to ensure complete dissolution of the powder. The prepared suspension should be shaken before use.

Overdose

Symptoms: increased risk of adverse reactions.

Treatment: gastric lavage; symptomatic and supportive therapy, which, if necessary, includes the use of antihistamines, corticosteroids, pressor amines, oxygen therapy, transfusion of infusion solutions, mechanical ventilation. It is not excreted in significant quantities by hemo- or peritoneal dialysis.

special instructions

Patients with a history of allergic reactions to penicillins may have increased sensitivity to cephalosporin antibiotics.

Long-term use of the drug may disrupt the normal intestinal microflora, which can lead to the growth of Clostridium difficile, causing severe diarrhea and pseudomembranous colitis.

During treatment, a positive direct Coombs test and a false positive urine test for glucose are possible.

Manufacturer

"Hikma Pharmaceuticals" (Jordan) by order of JSC "Gedeon Richter-RUS".

Storage conditions for the drug Suprax ®

Keep out of the reach of children.

Shelf life of the drug Suprax ®

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

Prices in Moscow pharmacies

The information is intended solely for comparing prices in stationary pharmacies operating in accordance with Article 55 of the Federal Law “On the Circulation of Medicines” dated April 12, 2010 N 61-FZ.

capsules 400 mg, 6 pcs.

Hikma Pharmaceuticals (Jordan)

capsules 400 mg, 6 pcs.

Hikma Pharmaceuticals (Jordan)

capsules 400 mg, 6 pcs.

granules for the preparation of suspension for oral administration 100 mg/5 ml 30.3-35.0 g, 1 pc.

Reviews

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Opinion of “Doctors of the Russian Federation” about the drug Suprax ®

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Suprax and Suprax Solutab - instructions for use (suspension, tablets, capsules 400 mg). Analogs, reviews about the drug, price

Varieties, names, release forms and composition

Currently, the antibiotic Suprax is available in two varieties, called Suprax and Suprax Solutab. In fact, these two types of the drug differ from each other only in names and forms of release, and there are no more differences between them, since they contain the same active substances, and they also have the same indications, contraindications and rules of use. That is why both Suprax and Suprax Solutab are often combined at the everyday level under one common name “Suprax”. In the further text of the article we will do the same, and by the general name “Suprax” we will mean both varieties of the same drug. We will indicate a specific dosage form and its name only if it is necessary to focus attention on any features of these varieties.

• Dispersible tablets (under the commercial name Suprax Solutab);
• Capsules for oral administration (under the commercial name Suprax);
• Granules for the preparation of an oral suspension (under the commercial name Suprax).

Dispersible (absorbable) tablets are sold under the name "Suprax Solutab", they are oblong, scored on both sides, pale orange in color and have a strawberry scent. Available in packs of 1, 5, 7 or 10 tablets.

Therapeutic effect

Suprax has an antibacterial effect, destroying pathogenic bacteria. It is a broad-spectrum antibiotic because it is destructive to a large number of different types of pathogenic bacteria. The destructive effect of Suprax for bacteria is due to its ability to disrupt the synthesis of the cell wall of pathogenic microbes, without which they simply cannot exist. Along with the destructiveness of Suprax for bacteria, the drug is at the same time safe for the human body, so it can be used to treat children starting from the age of six months.

• Citrobacter amalonaticus;
• Citrobacter diversus;
• Escherichia coli;
• Haemophilus influenzae;
• Haemophilus parainfluenzae;
• Klebsiella pneumoniae;
• Klebsiella oxytoca;
• Moraxella (Branhamella) catarrhalis;
• Morganella morganii;
• Neisseria gonorrhoeae;
• Proteus vulgaris;
• Proteus mirabilis;
• Pasteurella multocida;
• Providencia spp.;
• Streptococcus agalactiae;
• Streptococcus pneumoniae;
• Streptococcus pyogenes;
• Salmonella spp.;
• Shigella spp.;
• Serratia marcescens.

The following types of bacteria are resistant to the action of Suprax:

• Bacteroides fragilis;
• Clostridium spp.;
• Enterococcus (Streptococcus) group D;
• Enterobacter spp.;
• Listeria monocytogenes;
• Pseudomonas spp.;
• Staphylococcus spp.

The effectiveness of taking Suprax once a day for various diseases, according to studies by clinical pharmacologists in Hungary, is as follows:

• Pneumonia (pneumonia) – 90.9%;
• Tonsillopharyngitis – 92.6%;
• Exacerbation of chronic bronchitis – 72.2%;
• Sinusitis in children – 97.8%;
• Otitis media in children – 96.0%;
• Urinary tract infections – 95.0%.

40–50% of the total dose of Suprax taken is absorbed into the systemic circulation, and this amount does not depend on food intake. The antibiotic is excreted within 24 hours in an amount of about 60% of the dose taken. In this case, 50% is excreted unchanged in the urine, and 10% in bile. The remaining 40% of the dose taken is eliminated from the body within a few days.

Indications for use

Suprax and Suprax Solutab are indicated for use in the treatment of the same following infectious and inflammatory diseases of various organs caused by antibiotic-sensitive bacteria:

• Pharyngitis;
• Tonsillitis;
• Sinusitis;
• Acute and exacerbation of chronic bronchitis;
• Otitis media;
• Urinary tract infections (cystitis, urethritis, pyelonephritis, cystourethritis);
• Gonorrhea;
• Shigellosis.

Instructions for use

Suprax suspension - instructions for use

Suprax is produced and sold in the form of granules intended for the preparation of a suspension that is taken orally. The finished suspension can be used to treat adults and children older than six months. For young children, the suspension is the optimal dosage form of Suprax.

Also, for the convenience of parents, we provide below a table with dosages of the suspension for children with different body weights, which are valid when using a dosage syringe. This means that if you purchased a bottle with a dosage syringe, you do not have to calculate the dose of the medicine yourself, but use the one already calculated and shown in the table below. It should be remembered that the dosages in the table below are valid only for the dosing syringe, but for the dosing spoon they are different and are shown in the table above.

Suprax 400 (capsules) – instructions for use

Suprax in capsule form can be used to treat adults and adolescents over 12 years of age weighing more than 50 kg. This means that adults over 18 years of age can use the drug without restrictions, and adolescents over 12 years of age can only take Suprax in capsule form if their body weight is more than 50 kg. If a teenager weighs less than 50 kg, then he cannot take Suprax capsules, even if he is over 12 years old. This weight limit applies to adolescents aged 12–18 years.

Suprax Solutab tablets - instructions for use

The tablets are intended for use by adults over 18 years of age and children whose body weight has reached at least 25 kg. This means that adults over 18 years of age can use Suprax Solutab freely, and children can be given the tablets if they weigh 25 kg or more, regardless of their age.

• Infections of the respiratory tract and ENT organs - the duration of the course of therapy is 7 - 14 days;
• Tonsillopharyngitis caused by Streptococcus pyogenes - the duration of the course of therapy should be at least 10 days;
• Uncomplicated gonorrhea - Suprax Solutab is taken only once at a dose of 400 mg (1 tablet);
• Uncomplicated infections of the lower urinary tract (urethritis) in women - the duration of the course of therapy is 3 – 7 days;
• Uncomplicated infections of the upper urinary tract (pyelonephritis, cystitis) in women - the duration of the course of therapy is 14 days;
• Uncomplicated infections of the lower and upper urinary tract in men - the duration of treatment is 1 - 2 weeks.

In general, to determine the duration of the course of therapy, it is recommended to use the following rule: tablets should be taken within 1 to 2 days after the symptoms of infection disappear and/or body temperature normalizes.

special instructions

Tablets, suspension and capsules can be taken regardless of meals.

Use during pregnancy and breastfeeding

During pregnancy, Suprax can be used only if the expected benefit to the woman outweighs all possible risks to the fetus. In practice, cephalosporin antibiotics are often prescribed to pregnant women because they are relatively safe compared to other antibacterial drugs.

Suprax for children

Children under 12 years of age can only be given Suprax in the form of tablets or suspension. Suprax capsules are suitable for use only for children over 12 years of age with a body weight of at least 50 kg. This means that the capsules cannot be taken by children, even if they are over 12 years old but weigh less than 50 kg.

Impact on the ability to operate machinery

Since Suprax can cause side effects from the nervous system (dizziness, tinnitus, etc.), it has a negative effect on psychomotor activity and the ability to control machinery. Therefore, during the entire period of use of the drug, you should refrain from any activities that require a high speed of reactions and concentration.

Overdose

An overdose of Suprax in any dosage form is possible, and is manifested by increased severity of side effects (except allergic reactions). In case of overdose, you should rinse the stomach, take a sorbent (Activated carbon, Polyphepan, Polysorb, etc.) and then, if necessary, carry out symptomatic therapy in intensive care conditions, aimed at maintaining the normal functioning of vital organs and systems. Symptomatic therapy may include the use of glucocorticosteroids (Dexamethasone, Prednisolone, etc.), adrenaline (epinephrine), norepinephrine (norepinephrine), dopamine, as well as oxygen therapy, transfusion of various solutions and artificial ventilation.

Interaction with other drugs

Simultaneous use with tubular secretion blockers (Allopurinol, Probenecid, diuretics (Furosemide, Ethacrynic acid, Tobrasemide, etc.), penicillin antibiotics (Amoxicillin, Ampicillin, etc.), Phenylbutazone, etc.) leads to an increase in the concentration of Suprax in the blood, which may provoke an overdose of the latter.

Side effects

Various dosage forms of Suprax (dispersible tablets, capsules and oral suspension) can cause the following side effects on various organs and systems:

• Leukopenia (a decrease in the total number of leukocytes in the blood below normal);
• Neutropenia (a decrease in the number of neutrophils in the blood below normal);
• Thrombocytopenia (a decrease in the number of platelets in the blood below normal);
• Pancytopenia (decrease in the total number of red blood cells, white blood cells and platelets in the blood);
• Blood coagulation disorders and associated bleeding (prolongation of prothrombin time);
• Agranulocytosis (complete disappearance of basophils, eosinophils, neutrophils from the blood);
• Hemolytic anemia.

5. Urinary system:

• Interstitial nephritis;
• Increased creatinine levels in the blood (creatininemia);
• Increased urea levels in the blood (uremia);
• Hematuria (the appearance of blood in the urine);
• Acute renal failure.

6. Nervous system:

• Dyspnea;
• Swelling of the face;
• Vaginal itching;
• Vaginitis;
• Hypovitaminosis B.

If Lyell's syndrome develops, Suprax should be discontinued immediately and consult a doctor as a matter of urgency.

Contraindications for use

Suprax and Suprax Solutab are contraindicated for use if a person has the following conditions or diseases:

• Individual hypersensitivity or allergic reactions to antibiotics of the cephalosporin and/or penicillin groups;
• Individual hypersensitivity or allergic reactions to cefixime or any other auxiliary components of the drugs;
• Chronic renal failure in children under 18 years of age (for Suprax Solutab dispersible tablets);
• Impaired kidney function, in which creatinine clearance (CC) according to the Rehberg test is less than 60 ml/min (for capsules);
• The body weight of a child or adult is less than 25 kg (for Suprax Solutab dispersible tablets);
• Children under 12 years of age (for capsules);
• Children under six months of age (for granules for the preparation of a suspension for oral administration);
• Hereditary fructose intolerance, glucose and galactose malabsorption, sucrase and isomaltase deficiency (for granules for oral suspension).

In addition, Suprax in any dosage form (dispersible tablets, capsules and suspension) should be used with caution and under supervision if a person has the following conditions or diseases:

• Old age (over 65 years old);
• Chronic renal failure;
• Pseudomembranous colitis suffered in the past.

Analogs

Currently, Suprax has two types of analogues on the domestic pharmaceutical market - these are synonymous drugs and, in fact, analogues. Synonyms for Suprax are medications that also contain cefixime as an active ingredient. Actually, analogues are drugs that do not contain the same active substance as Suprax, but have the most similar spectrum of therapeutic action. This means that analogues of Suprax are antibiotics belonging to the cephalosporin group (to which Suprax itself belongs).

• Ixim Lupine powder for the preparation of suspension for oral administration;
• Panzef granules for the preparation of suspension for oral administration, tablets;
• Cemidexor tablets;
• Ceforal Solutab dispersible tablets.

The following antibiotics are analogues of Suprax:

• Azaran powder for solution for injection;
• Axone powder for the preparation of solution for injection;
• Bacperazone powder for the preparation of solution for injection;
• Bestum powder for the preparation of solution for injection;
• Betasporin powder for the preparation of solution for injection;
• Biotriaxone powder for the preparation of solution for injection;
• Broadsafe-S powder for the preparation of solution for injection;
• Vicef powder for the preparation of solution for injection;
• Dardum powder for solution for injection;
• Intrataxime powder for the preparation of solution for injection;
• Ificef powder for solution for injection;
• Kefotex powder for the preparation of solution for injection;
• Clafobrine powder for the preparation of solution for injection;
• Klaforan powder for the preparation of solution for injection;
• Lendacin powder for the preparation of solution for injection and infusion;
• Lifaxon powder for solution for injection;
• Liforan powder for the preparation of solution for injection;
• Lorazidim powder for solution for injection;
• Loraxone powder for solution for injection;
• Medaxone powder for solution for injection;
• Medocef powder for the preparation of solution for injection;
• Movigip powder for the preparation of solution for injection;
• Movoperiz powder for the preparation of solution for injection;
• Operaz powder for the preparation of solution for injection;
• Orzid powder for the preparation of solution for injection;
• Oritax powder for the preparation of solution for injection;
• Oritaxim powder for the preparation of solution for injection;
• Oframax powder for the preparation of solution for injection;
• Pactocef powder for the preparation of solution for injection;
• Resibelact powder for solution for injection;
• Roceferin powder for solution for injection;
• Rocephin powder for the preparation of solution for injection and infusion;
• Sefpotek tablets;
• Spectracef tablets;
• Stericef powder for the preparation of solution for injection;
• Sulzoncef powder for the preparation of solution for injection;
• Sulmover powder for the preparation of solution for injection;
• Sulperazon powder for the preparation of solution for injection;
• Sulperacef powder for the preparation of solution for injection;
• Sulcef powder for the preparation of solution for injection;
• Sulcefazone powder for solution for injection;
• Tax-o-bid powder for the preparation of solution for injection;
• Talcef powder for the preparation of solution for injection;
• Tarcefoxime powder for solution for injection;
• Terzef powder for the preparation of solution for injection;
• Tizim powder for the preparation of solution for injection;
• Torocef powder for the preparation of solution for injection;
• Triaxone powder for solution for injection;
• Fortazim powder for the preparation of solution for injection;
• Fortoferin powder for solution for injection;
• Fortum powder for the preparation of solution for injection;
• Hizon powder for solution for injection;
• Cebanex powder for solution for injection;
• Cedex capsules and powder for the preparation of suspension for oral administration;
• Ceperon J powder for the preparation of solution for injection;
• Cetax powder for the preparation of solution for injection;
• Cephabol powder for solution for injection;
• Cefaxone powder for solution for injection;
• Cefantral powder for solution for injection;
• Cefathrin powder for solution for injection;
• Cefzide powder for solution for injection;
• Cefzoxime J powder for solution for injection;
• Cefobid powder for the preparation of solution for injection;
• Cefogram powder for the preparation of solution for injection;
• Cefoperabol powder for the preparation of solution for injection;
• Cefoperazone powder for solution for injection;
• Cefoperus powder for solution for injection;
• Cefosin powder for the preparation of solution for injection;
• Cefotaxime powder for solution for injection;
• Cefpar and Cefpar SV powder for the preparation of solution for injection;
• Cefson powder for the preparation of solution for injection;
• Ceftazidime powder for solution for injection;
• Ceftidine powder for solution for injection;
• Ceftriabole powder for the preparation of solution for injection;
• Ceftriaxone powder for solution for injection.

Suprax - analogues are cheaper

The following analogue drugs are cheaper than Suprax:

• Klaforan - price per bottle of powder 160 - 200 rubles;
• Sulperazon - price per bottle of powder 300 - 400 rubles;
• Fortum - price per bottle 200 - 600 rubles;
• Cefaxon - price per bottle 160 - 250 rubles;
• Cefantral - price per bottle 80 - 120 rubles;
• Cephobid - price per bottle 300 - 350 rubles;
• Cefosin - price per bottle 40 - 60 rubles;
• Cefotaxime produced in Russia, Belarus, Ukraine, China or India - price per bottle is 20 - 40 rubles;
• Ceftazidime – price per bottle 75 – 160 rubles;
• Ceftriaxone produced in Russia, Belarus, Ukraine, China or India - price per bottle is 20 - 40 rubles.

Reviews

Most of the reviews about Suprax (from 70 to 80%) are positive, due to its high effectiveness for the treatment of severe, protracted infectious diseases of the respiratory and genitourinary systems, as well as ENT organs in children and adults.

Suprax (Suprax suspension, Suprax 400, Suprax tablets) – price

Currently, the cost of various forms of Suprax and Suprax Solutab in pharmacies in Russian cities varies within the following limits:

• Suprax, granules for preparing a suspension – 540 – 682 rubles;
• Suprax, capsules, 6 pieces – 669 – 845 rubles;
• Suprax Solutab, tablets, 7 pieces – 790 – 1042 rubles.

Author: Nasedkina A.K. Specialist in research of biomedical problems.

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