Flixonase spray price

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Flixonase

Description current as of 06/22/2016

  • Latin name: Flixonase
  • ATX code: R01AD08
  • Active ingredient: Fluticasone (Fluticasone)
  • Manufacturer: Glaxo Wellcome (Spain); GlaxoSmithKline Pharmaceuticals (Poland)

Compound

The drug contains the main component: fluticasone propionate.

Table of contents:

Additional ingredients: dextrose, carboxymethylcellulose and microcrystalline cellulose, phenylethyl alcohol, benzalkonium chloride solution, hydrochloric acid, polysorbate 80 and purified water.

Release form

Flixonase is produced in the form of a nasal spray, packaged in bottles of 60 and 120 doses, in cardboard packaging.

pharmachologic effect

The spray has anti-allergic, anti-edematous and anti-inflammatory effects.

Pharmacodynamics and pharmacokinetics

This drug exhibits an anti-inflammatory effect due to interaction with GCS receptors. In this case, there is a suppression of the proliferation of mast cells, lymphocytes, eosinophils, macrophages and neutrophils. Thanks to fluticasone propionate, the production of inflammatory mediators and other biologically active components, such as histamine, cytokines and leukotrienes, is reduced at the early and later stages of allergic reactions. As a result, the patient's response to bronchodilators is restored, allowing the frequency of their use to be reduced. The frequency of sneezing, itching in the nose decreases, a runny nose and nasal congestion, discomfort in the paranasal sinuses and a feeling of pressure on the nose and eyes are eliminated. In addition, eye symptoms related to allergic rhinitis are alleviated.

The use of the spray has a rapid anti-inflammatory effect on the nasal mucosa 2-4 hours after the first injection.

Reduction in the severity of symptoms, mainly nasal congestion, can persist for at least a day after administration of a single dose.

The use of the drug in compliance with the recommended dosages does not cause the severity of its systemic activity and does not contribute to the suppression of the hypothalamic-pituitary-adrenal system.

Intranasal administration of the spray does not lead to detection of the drug in the blood plasma. This product is characterized by low absorption, since most of it is swallowed. The absorption of their gastrointestinal tract into the blood is only about 1% of the dose taken. However, fluticasone propionate undergoes rapid distribution and significant plasma protein binding. The drug is eliminated from the body quite quickly, mainly in the form of metabolites in the bile.

Indications for use

It is recommended to use Flixonase spray for:

Contraindications

The drug is not prescribed for:

  • hypersensitivity to it;
  • children under 4 years of age.

Side effects

When treated with Flixonase, side effects may develop in the form of significant dryness and irritation of the nasopharynx, headaches, distortion of smell or taste, and nosebleeds.

It is also possible that hypersensitivity reactions may occur, for example: skin rash, swelling of the face and tongue, bronchospasm.

In rare cases, local reactions are possible: nasal congestion, burning, discomfort.

Flixonase spray instructions for use (Method and dosage)

Detailed instructions for use of Flixonase recommend administering it intranasally. For patients over 12 years of age, the drug is prescribed for the prevention and treatment of various forms of allergic rhinitis. In this case, the medicine must be injected 2 times into each nasal passage 1-2 times a day. Once control of symptoms is achieved, the dosage is reduced to one administration once a day.

In this case, the maximum permissible daily dosage of Flixonase is up to 4 injections.

For pediatric patients aged 4-12 years, during preventive measures and treatment of rhinitis, the drug can be injected once a day into each nasal passage.

Regular use of the drug contributes to achieving the full therapeutic effect. It has been established that these nasal drops do not exhibit an immediate therapeutic effect; this usually occurs after 3-4 days from the start of use.

Overdose

There is no information on overdose with this drug. However, manufacturers do not rule out that disturbances in the activity of the hypothalamic-pituitary-adrenal system and suppression of adrenal function may develop if the spray is used for a long time in increased dosages.

As a rule, this does not require special treatment - just adjusting the dosage and monitoring the level of cortisol in the plasma.

Interaction

It has been established that when using Flixonase, low concentrations of its active substance fluticasone propionate are formed in the blood plasma. Therefore, significant interactions are unlikely to occur.

However, combination with Ritonavir and other inhibitors of the CYP3A4 isoenzyme of the cytochrome P450 enzyme system may increase the concentration of this drug.

special instructions

This drug can only be used intranasally, with a treatment duration of up to 6 months. If treatment continues longer than this period, then monitoring of the activity of the adrenal cortex is required.

The full effect of the spray appears only after a few days of use, so you should adhere to a regular therapeutic regimen.

Usually, for most patients, this drug is enough to eliminate the signs of seasonal allergic rhinitis, but sometimes additional treatment may be required, for example, to relieve ophthalmic manifestations.

Terms of sale

Storage conditions

The spray can be stored under normal conditions at temperatures up to 30°C, out of the reach of children.

Best before date

Use of Flixonase during pregnancy

It should be noted that during pregnancy this drug can be used only as prescribed by a doctor, when the expected benefit is much higher than the possible harm.

Flixonase analogs

Reviews about Flixonase

Many reviews about this drug can be found on various forums, the topics of which are devoted to the treatment of allergic rhinitis. Users also actively discuss ways to prevent this disorder and the effectiveness of other drugs with a similar effect.

Quite often, patients leave reviews of Flixonase as an effective drug that brings great relief in the manifestations of allergic rhinitis. However, some users report that the treatment did not bring complete recovery. For example, even using the spray for a month did not help eliminate swelling and completely restore the sense of smell.

In addition, there are descriptions of cases of intolerance to the drug, which were manifested by severe swelling, copious watery discharge and even greater nasal congestion.

Users are also actively discussing the topic of possible interchangeability of drugs, which medicines for allergic rhinitis are the most effective, how safe they are, how comfortable they are to use, and so on.

As for Flixonase, reviews from doctors only confirm its high effectiveness. At the same time, they once again note that it can be used according to indications, with a definitively clarified diagnosis. It is important to follow the dosage, regimen and other features of administration. Only in this case can one expect a good treatment outcome, without complications and side effects.

Flixonase price, where to buy

The price of Flixonase spray varies within rubles.

  • Online pharmacies in Russia Russia

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Ekaterina: Since childhood, when I worry, my stomach shrinks and becomes a lump, and then it hurts.

Svetlana: I constantly go on diets, and because of this I have problems with stool. Girlfriend for me.

Lily: And if it’s a thorn, can you drip some drops?

Gray: Tablets are effective, I didn’t think that only tablets would help me restore my .

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/fliksonaze

FLIXONASE

◊ Nasal spray dosed in the form of an opaque white suspension, free of foreign particles.

Excipients: dextrose - 5 mg, Avicel RC591 (microcrystalline cellulose, sodium carmellose) - 1.5 mg, phenylethanol - 0.25 mg, benzalkonium chloride* - 0.02 mg, polysorbate 005 mg, hydrochloric acid** - up to pH 6.3-6.5, water purified - up to 100 mg.

* added as an aqueous solution according to the European Pharmacopoeia.

** add to achieve pH 6.3-6.5 if the pH of the final suspension is above 6.8.

60 doses - yellow glass bottles with a dosing device and adapter (1) - plastic cases with a booklet label.

120 doses - yellow glass bottles with a dosing device and adapter (1) - plastic cases with a booklet label.

120 doses - polypropylene bottles with a dosing device and adapter (1) - plastic cases with a booklet label.

GCS for intranasal use. Has a pronounced anti-inflammatory effect. When administered intranasally, there is no systemic effect and practically does not inhibit the hypothalamic-pituitary-adrenal system.

There was no significant change in daily serum cortisol AUC after fluticasone propionate 200 mcg/day compared with placebo (ratio: 1.01, 90% CI 0.9 to 1.14).

The anti-inflammatory effect of fluticasone propionate is realized as a result of its interaction with glucocorticoid receptors. Suppresses the proliferation of mast cells, eosinophils, lymphocytes, macrophages, neutrophils. Fluticasone propionate reduces the production of inflammatory mediators and a number of biologically active substances (including histamine, prostaglandins, leukotrienes, cytokines) during the early and late phases of the allergic reaction. Has a rapid anti-inflammatory effect on the nasal mucosa. The antiallergic effect appears within 2-4 hours after the first use. Reduces sneezing, nasal itching, rhinorrhea, nasal congestion, discomfort in the sinuses and pressure around the nose and eyes. In addition, it relieves eye symptoms associated with allergic rhinitis. Reduction in the severity of symptoms (especially nasal congestion) persists for 24 hours after a single use of the spray at a dose of 200 mcg.

Fluticasone propionate improves the quality of life of patients, including physical and social activity.

After intranasal administration of fluticasone propionate (200 mcg/day), Cmax in the blood plasma at steady state is not quantitatively determined in most patients (less than 0.01 ng/ml). Cmax 0.017 ng/ml. Direct absorption from the nasal mucosa is unlikely due to the low solubility of the drug in water and ingestion of most of the drug. When taken orally, absolute bioavailability is low (less than 1%) as a result of a combination of incomplete absorption from the gastrointestinal tract and active first-pass metabolism through the liver. The total systemic absorption is therefore extremely low.

In the equilibrium state, fluticasone propionate has a large V d - about 318 l. Plasma protein binding is high - about 91%.

Fluticasone propionate is rapidly eliminated from the systemic circulation mainly due to metabolism in the liver with the formation of inactive carboxylic acid via the CYP3A4 isoenzyme. Metabolism of the ingested fraction of fluticasone propionate during the “first pass” through the liver occurs in the same way.

The elimination of fluticasone propionate is linear in the dose range from 250 to 1000 mcg and is characterized by a high plasma clearance (1.1 l/min).

Cmax decreases by approximately 98% within 3-4 hours, and only at very low concentrations in plasma a final half-life of 7.8 hours was observed. Renal clearance of fluticasone propionate is insignificant (less than 0.2%), and the inactive metabolite - carboxylic acid - less than 5%.

Fluticasone propionate and its metabolites are mainly excreted in bile through the intestines.

Treatment of year-round and seasonal allergic rhinitis, including hay fever (hay fever) in adults and children over 4 years of age:

- pain, feeling of pressure in the paranasal sinuses;

- nasal congestion, sneezing, itchy nose;

- hypersensitivity to fluticasone propionate and other components of the drug;

- children under 4 years of age;

- recent trauma to the nose or surgery of the nasal cavity.

Before using the drug, the patient should consult a doctor in the following cases:

- taking medications to treat HIV infection, such as ritonavir;

- taking corticosteroids for the treatment of bronchial asthma, allergies, skin rashes;

- taking medications to treat fungal infections, such as ketoconazole;

- taking other potent inhibitors of the CYP3A isoenzyme, for example, itraconazole;

- if you have glaucoma or cataracts.

Use with caution if you have a nasal or sinus infection. It should be borne in mind that infectious diseases of the nose require appropriate treatment, but are not a contraindication to the use of Flixonase nasal spray.

Flixonase is intended for intranasal use only. To achieve the full therapeutic effect, the drug should be used regularly. The maximum therapeutic effect appears after 3-4 days of therapy.

Adults and children over 12 years old

1st week: 2 injections into each nostril 1 time/day (200 mcg/day);

from the 2nd week to 3 months: 1 or 2 injections into each nostril 1 time / day (mcg / day).

The maximum daily dose is kg/day (no more than 2 injections into each nostril).

Elderly patients are prescribed the usual dose intended for adults.

Children aged 4 to 12 years

1 injection into each nostril 1 time/day (100 mcg/day). Do not exceed the recommended dose (100 mcg/day). In children aged 4 to 12 years, the drug should be used for the shortest period of time necessary to achieve control of symptoms of the disease. It is necessary to consult your doctor if your child needs to use the drug for a period of time exceeding 2 months a year.

The maximum daily dose is kg (no more than 1 injection in each nostril).

If there is no effect from the use of the drug in all age groups of patients, it is necessary to consult a doctor.

Rules for using the drug

Before use, shake the bottle carefully and take it by placing your index and middle fingers on either side of the tip and your thumb under the bottom.

When using the drug for the first time or a break in its use for more than 1 week, you should check the serviceability of the sprayer: point the tip away from you, make several presses until a small cloud appears from the tip. Next, you need to clear your nose (blow your nose). Close one nostril and insert the tip into the other nostril. Tilt your head slightly forward while continuing to hold the bottle vertically. Then you should begin to inhale through your nose and, continuing to inhale, press once with your fingers to spray the drug. Exhale through your mouth. Repeat the procedure for a second spray in the same nostril, if necessary. Next, repeat the described procedure completely, inserting the tip into the other nostril. After use, blot the tip with a clean napkin or handkerchief and close it with the cap.

The sprayer should be washed at least once a week. To do this, carefully remove the tip and rinse it in warm water. Shake off excess water and leave to dry in a warm place. Avoid overheating. Then carefully place the tip in its original place at the top of the bottle. Put on the protective cap.

If the hole in the tip is clogged, the tip should be removed as described above and left in warm water for a while. Then rinse under running cold water, dry and put back on the bottle. Do not clean the tip hole with a pin or other sharp objects.

Determination of the frequency of side effects: very often (≥1/10), often (≥1/100 and <1/10), infrequently (≥1/1000 and <1/100), rarely (≥1/and <1/1000 ), very rare (<1/10,000, including isolated cases).

Very common, common and infrequent adverse reactions are mainly established on the basis of clinical trial data. Rare and very rare reactions are mainly determined from spontaneous reports.

When generating the incidence of adverse reactions, background rates in the placebo group were not taken into account, but were not taken into account, since they were generally comparable to the active treatment group.

From the immune system: very rarely - hypersensitivity reactions, incl. bronchospasm, rash, swelling of the face and tongue, anaphylactic reactions, anaphylactoid reactions.

From the nervous system: often - headache, unpleasant taste and smell. Headache and unpleasant taste and odor have also been reported with other nasal sprays.

From the organ of vision: very rarely - glaucoma, increased intraocular pressure, cataracts. A small number of spontaneous reports were associated with long-term drug therapy.

From the respiratory system: very often - nosebleeds; often - dryness of the mucous membrane in the nasal cavity and pharynx, irritation of the mucous membrane in the nasal cavity and pharynx (these adverse reactions, as well as nosebleeds, were also observed when using other intranasal drugs); very rarely - perforation of the nasal septum (reported when taking intranasal corticosteroids).

When using some intranasal corticosteroids, systemic effects may develop, especially when administered in high doses for a long time.

There are no data on acute and chronic overdose of the drug.

When administered intranasally to healthy volunteers, 2 mg of fluticasone propionate 2 times a day for 7 days had no effect on the function of the hypothalamic-pituitary-adrenal system (doses 20 times higher than the therapeutic one). Use of the drug in doses higher than recommended for a long time can lead to temporary suppression of adrenal function.

In case of overdose, the patient should consult a doctor.

With simultaneous use of fluticasone propionate with ritonavir, which is a strong inhibitor of the CYP3A4 isoenzyme, a significant increase in the concentration of fluticasone propionate in blood plasma is possible. As a result, there is a sharp decrease in serum cortisol concentration. The use of inhaled or intranasal fluticasone propionate and ritonavir leads to the development of side effects due to the systemic action of GCS, including Cushing's syndrome and suppression of adrenal function. Therefore, concomitant use of fluticasone propionate and ritonavir should be avoided unless the potential benefit outweighs the risk of systemic effects.

Concomitant use of fluticasone propionate with other, less potent inhibitors of the CYP3A4 isoenzyme, such as ketoconazole and itraconazole, leads to increased exposure to fluticasone propionate and an increased risk of systemic side effects. Caution is recommended and, if possible, avoiding long-term co-administration of these drugs.

Inhibitors of the CYP3A4 isoenzyme cause a negligible (erythromycin) or insignificant (ketoconazole) increase in plasma fluticasone propionate concentrations, which do not entail any noticeable decrease in serum cortisol concentrations. However, caution should be exercised when concomitantly using inhibitors of the CYP3A4 isoenzyme (for example, ketoconazole) and fluticasone propionate due to the possible increase in plasma concentrations of the latter.

The drug is indicated for intranasal use only.

For adults and children over 12 years of age: Do not use Flixonase nasal spray for more than 3 months. If it is necessary to use the drug for more than 3 months, consult a doctor.

For children from 4 to 12 years old: Do not use Flixonase nasal spray for more than 2 months. If it is necessary to use the drug for more than 2 months, consult a doctor. With long-term use, regular monitoring of the function of the adrenal cortex is necessary.

There are reports of systemic effects when using nasal corticosteroids, especially in high doses for a long time. These effects are much less likely than with oral administration. Systemic effects may occur with nasal corticosteroids, particularly when used in high doses over a long period of time. These effects are much less likely to occur than with oral corticosteroids and may vary in individual patients and between different corticosteroid medications.

Possible systemic effects may include Cushing's syndrome, Cushing's signature features, adrenal suppression, growth retardation in children and adolescents, cataracts, glaucoma, and less commonly a number of psychological or behavioral effects including psychomotor hyperactivity, sleep disturbances, anxiety, depression, or aggression (in characteristics in children).

Growth retardation was observed in children receiving therapy with certain intranasal corticosteroids in approved doses. It is recommended to regularly monitor the growth of children receiving long-term treatment with intranasal corticosteroids. If growth slows, treatment should be reconsidered in order to reduce the dose of intranasal corticosteroids, if possible, to the minimum dose that ensures effective control of symptoms and contact a pediatrician.

Concomitant use of ritonavir and fluticasone propionate should be avoided unless the potential benefit to the patient outweighs the possible risk of systemic corticosteroid side effects.

It is recommended to stop taking the drug and consult a doctor if there is no improvement within 4 days. Consultation with a doctor is also necessary if the patient develops new symptoms, such as severe facial pain, thick nasal discharge, which may indicate an infection and are not related to allergies.

Infections of the nasal cavity or paranasal sinuses require appropriate treatment, but are not a contraindication to the use of Flixonase nasal spray.

For most patients, fluticasone propionate nasal spray relieves the symptoms of seasonal allergic rhinitis, but in some cases, when the concentration of allergens in the air is very high, additional therapy may be necessary.

Additional therapy may be required to relieve eye symptoms during successful treatment of seasonal allergic rhinitis.

To achieve maximum therapeutic effect, it is necessary to adhere to a regular regimen of use.

Caution must be exercised when transferring patients from treatment with systemic corticosteroids to treatment with fluticasone propionate in the form of a nasal spray, especially if there is impaired adrenal function during regular monitoring.

Flixonase aqueous nasal spray contains benzalkonium chloride, which may cause bronchospasm.

In case of contact with patients with chickenpox, measles, or in case of changes in vision, it is recommended to stop treatment and consult a doctor.

Impact on the ability to drive vehicles and machinery

In clinical studies, no data were obtained on the effect of the drug on the ability to drive vehicles and other mechanisms, however, the side effects that the drug may cause should be taken into account.

Before using Flixonase during pregnancy and lactation, you should consult your doctor.

Pregnant and lactating women should only be prescribed Flixonase if the expected benefit to the patient outweighs any possible risk to the fetus or child.

For children aged 4-12 years, it is recommended to administer 50 mcg (1 dose) in each nostril 1 time/day. The maximum daily dose of the drug is 200 mcg (2 doses in each nostril). Contraindication: children under 4 years of age.

Elderly patients do not require dosage adjustment.

The drug should be stored out of the reach of children at a temperature not exceeding 30°C. Shelf life – 3 years.

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Source: http://health.mail.ru/drug/flixonase/

Flixonase

Release forms

Sale: by prescription

Storage: 15-25C (room temperature)

Shelf life: 24 months.

Instructions for flixonase

Flixonase (fluticasone propionate) is a local glucocorticosteroid for the prevention and treatment of allergic rhinitis (hereinafter referred to as AR). This disease is common and easily transforms into bronchial asthma and significantly reduces the patient’s quality of life. AR develops under the influence of various allergens and is characterized by a complex of symptoms, including difficulty in nasal breathing, swelling of the mucous membrane of the nasal passages, itching and rhinorrhea. The prevalence of AR not only does not decrease, but also progressively increases at such a pace that it can be considered a full-fledged epidemic. Two main methods are used to treat AR: allergen elimination and drug therapy. It is obvious that the first method is superior to the second in efficiency. However, it is not always possible to identify the allergen or eliminate contact with it. In this regard, pharmacotherapy occupies the main place in the treatment of AR. Treatment of AR can be symptomatic, i.e. aimed at eliminating the symptoms of the disease (for example, vasoconstrictors, antihistamines) and pathogenetic, affecting the cause of the disease. An example of drugs for the pathogenetic treatment of AR are intranasal glucocorticosteroids. One such medicine is Flixonase. Unlike oral H1-histamine receptor blockers and topical vasoconstrictors, Flixonase effectively affects the entire symptom complex of AR: copious nasal mucus, itching, sneezing, obstruction of the nasal canals.

The effect of the drug can be felt within 2 hours after taking a single dose. A special feature of Flixonase is the persistence of the therapeutic effect, which lasts throughout the day, which eliminates the need to use the drug several times a day. In clinical studies, Flixonase demonstrated advantages over many drugs traditionally used in the treatment of AR, for example, loratadine, cytirizine in combination with montelukast. Flixonase is well tolerated by patients: during clinical studies, it was demonstrated that the drug does not cause side effects inherent in systemic glucocorticosteroids. Flixonase should not be taken by persons with individual intolerance to fluticasone. In pediatric practice, the drug can be used starting from 4 years of age. One of the conditions for the effectiveness of the drug is the regularity of its use. The frequency of use of Flixonase is 1 time per day, a single dose is 2 injections into each nasal passage, and for persons under 12 years of age – 1 injection. Long-term (more than six months) use of Flixonase is possible only under the supervision of a physician with mandatory monitoring of the function of the adrenal cortex. The drug does not affect the speed of reactions, attention and concentration.

Reviews from doctors about flixonase

Flixonase is a good topical hormone for the treatment of ENT diseases, very effective for allergic rhinitis, adenoiditis, after and before surgical treatment of polypous or cystic sinusitis. Easy to use. The price is affordable, the quality matches, there are a lot of doses, enough for a course of treatment.

Possible side effects.

Before use, you need to consult an ENT doctor; not everyone is prescribed this drug and it does not help everyone.

Patient reviews of flixonase

During rhinitis in pregnant women, I developed an addiction to vasoconstrictor medications and was on them for more than a year. To give them up, I was advised to use Flixonase. I tried it, used it once in the morning and once at night, continuing to instill vasoconstrictors. Just a couple of days later my nose began to breathe. Myself! Without the use of any drugs! The price is rather high, but for such an effect, I would pay more.

I have suffered from allergies for many years, my nose is constantly stuffy, and it really interferes with my life. I tried many remedies and settled on Flixonase. The product is indeed very powerful and effective, but only if you use it constantly. When I stop taking it, everything immediately comes back. I’ll tell you a secret, allergies cannot be treated in any way. It is possible to relieve symptoms only temporarily.

Flixonase was recommended to me by a very good ENT specialist whom I trust. I suffered from a runny nose for years, vasomotor rhinitis. I took a couple of courses with a break in parallel with homeopathic tablets. Pre-washed with sea water. As a result, I gave up vasoconstrictor drops; I couldn’t imagine existing without them. The mucous membrane has recovered, runny noses are now much less common.

I started using this medicine when I had allergic rhinitis and my doctor advised me to buy Frixonase. After using it, the swelling and runny nose itself decreased significantly. I recommend this medicine for use. It is indeed very effective in dealing with allergic manifestations.

For a long time I could not get rid of such a problem as allergic rhinitis. I tried many medications that helped for a while and the allergy reappeared. I started taking Flixonase according to a doctor’s prescription and I never had any allergies. The only negative was that there was slight irritation of the nasopharynx during use. The doctor said that this could happen, there is nothing wrong with it.

Flixonase is the savior of my nose! Having suffered from sinusitis several times, this sore became my chronic life companion - constant nasal congestion, pain in the bridge of the nose, and with any forward bending the swelling only grew even more. And by spring, allergies were added to all the symptoms - my nose was constantly itching, and I was tormented by discharge from it. I tried everything - from the most expensive drugs to folk remedies, but then my friend (doctor) recommended Flixonase to me. So he saved me. After several uses, I immediately felt the effect. The drug is not addictive - this also made me very happy. Now I recommend Flixonase exclusively to all my loved ones!

For five years I couldn’t sleep without dripping in my nose. As a result, I developed an allergy, and any drops or nasal sprays only made the situation worse, and I practically could not breathe. The doctor recommended antibiotics and Flixonase. For me, this medicine became a salvation and now saves me every time I have a cold. A runny nose goes away in 2-3 days.

My acquaintance with Flixonase began when my child’s rhinitis became an endless problem. We tried different medications, but there was no end in sight to this constant nasal discharge. It was necessary to change not only the medications, but also the doctors who prescribed them. After six months of “going through the pain,” we met a wonderful doctor, to whom I am incredibly grateful. Parents of children who have been ill for a long period will understand me. We were prescribed Flixonase and soon said goodbye to lingering rhinitis. The drug is not cheap, but it is worth it.

A wonderful drug for getting rid of dependence on naphthyzine and similar drugs for rhinitis. The fact is that long-term use of drugs such as naphthyzine and xylometazoline causes hypertrophy of the mucous membrane of the nasal passages. A vicious circle develops. The more and more often you use it, the more you aggravate the situation. Flixonase helps with rhinitis more effectively, does not cause mucosal hypertrophy and addiction. And in my situation, it helped me get rid of my addiction to naphthyzine. I recommend using this drug for rhinitis. Well, use naphthyzin for no more than two to three days.

Instructions for use of flixonase

pharmachologic effect

GCS for intranasal use. It has a pronounced anti-inflammatory, anti-edematous and anti-allergic effect.

The anti-inflammatory effect is realized as a result of the interaction of the drug with glucocorticosteroid receptors. Suppresses the proliferation of mast cells, eosinophils, lymphocytes, macrophages, neutrophils. Fluticasone propionate reduces the production of inflammatory mediators and a number of biologically active substances (including histamine, prostaglandins, leukotrienes, cytokines) during the early and late phases of the allergic reaction. Has a rapid anti-inflammatory effect on the nasal mucosa. The antiallergic effect appears within 2-4 hours after the first use. Reduces sneezing, nasal itching, rhinorrhea, nasal congestion, discomfort in the sinuses and pressure around the nose and eyes. In addition, it relieves eye symptoms associated with allergic rhinitis. Reduction in the severity of symptoms (especially nasal congestion) persists for 24 hours after a single use of the spray at a dose of 200 mcg.

Fluticasone propionate improves the quality of life of patients, including physical and social activity.

When used in recommended doses, the drug has no systemic effect and practically does not inhibit the hypothalamic-pituitary-adrenal system.

Pharmacokinetics

After intranasal administration of fluticasone propionate (200 mcg/day), C max in the blood plasma is not determined in most patients (i.e., less than 0.01 ng/ml). The highest Cmax value is 0.017 ng/ml. Direct absorption from the nasal mucosa is negligible due to the low solubility of the drug in water, as a result of which most of the dose is ultimately swallowed. When taking fluticasone propionate orally, less than 1% of the dose is absorbed into the blood due to low absorption and first-pass metabolism. These reasons are responsible for the extremely low total absorption from the nasal cavity and gastrointestinal tract (of the swallowed drug).

fluticasone propionate reaches C ss d - about 318 l.

Plasma protein binding is about 91%.

Fluticasone propionate undergoes a “first pass” effect through the liver and is metabolized with the participation of the CYP3A4 isoenzyme to form an inactive carboxyl metabolite.

It is excreted mainly in bile unchanged and in the form of metabolites.

Release form, composition and packaging

Nasal spray dosed in the form of a white opaque suspension, free of foreign particles.

Excipients: anhydrous dextrose, microcrystalline cellulose, microcrystalline carboxymethylcellulose, phenylethyl alcohol, benzalkonium chloride solution, polysorbate 80, diluted hydrochloric acid, purified water.

60 doses - dark glass bottles with a dosing device and adapter (1) - cardboard packs.

120 doses - dark glass bottles with a dosing device and adapter (1) - cardboard packs.

Dosage regimen

Flixonase is intended for intranasal use only. To achieve the full therapeutic effect, the drug should be used regularly.

Adults and children over 12 years of age are prescribed 100 mcg (2 doses) in each nostril 1 time/day (total dose 200 mcg/day), preferably in the morning. After achieving control of symptoms, you can prescribe 50 mcg (1 dose) in each nostril 1 time / day (total dose 100 mcg / day).

In some cases, it is necessary to use 100 mcg (2 doses) in each nostril 2 times / day (total dose 400 mcg / day) for a short time in order to achieve control of symptoms, after which the dose can be reduced. The maximum daily dose of the drug is 400 mcg (4 doses in each nostril).

Elderly patients do not require dosage adjustment.

For children aged 4-12 years, it is recommended to administer 50 mcg (1 dose) in each nostril 1 time/day. The maximum daily dose of the drug is 200 mcg (2 doses in each nostril).

The maximum therapeutic effect appears after 3-4 days of therapy. To achieve the full therapeutic effect, it is necessary to use the drug regularly.

Before use, shake the bottle carefully, take it by placing your index and middle fingers on either side of the tip, and your thumb under the bottom. When using the drug for the first time or a break in its use for more than 1 week, you should check the serviceability of the sprayer (pointing the tip away from you, make several presses until a small cloud appears from the tip).

- clear your nose (blow your nose lightly);

- close one nostril and insert the tip into the other nostril;

— tilt your head slightly forward, continuing to hold the aerosol bottle vertically;

- begin to inhale through your nose and, continuing to inhale, press once with your fingers to spray the drug;

- exhale through your mouth.

Repeat the procedure for a second spray in the same nostril, if necessary. Next, repeat the described procedure completely, inserting the tip into the other nostril.

After use, blot the tip with a clean napkin or handkerchief and close it with the cap.

The sprayer should be washed at least once a week. For this purpose, you must carefully remove the tip and rinse it in warm water. Shake off excess water and leave to dry in a warm place. Avoid overheating. Then carefully place the tip in its original place at the top of the brown bottle. Put on the protective cap. If the tip hole is clogged, the tip should be removed as described above and left in warm water for a while. Then rinse under running cold water, dry and put back on the bottle. Do not clean the tip hole with a pin or other sharp objects.

Overdose

Drug interactions

Due to the very low plasma concentrations of fluticasone propionate after administration of Flixonase, a clinically significant interaction is unlikely.

With simultaneous use of Flixonase with ritonavir, which is a strong inhibitor of the CYP3A4 isoenzyme, a significant increase in the concentration of fluticasone propionate in the blood plasma is possible. As a result, there is a sharp decrease in serum cortisol concentrations, and side effects due to the systemic action of corticosteroids develop, including Cushing's syndrome and suppression of adrenal function.

With simultaneous use of Flixonase with other inhibitors of the CYP3A4 isoenzyme, a negligible (with erythromycin) or insignificant (with ketoconazole) increase in the concentrations of fluticasone propionate in the blood plasma is observed, which does not cause a noticeable decrease in serum cortisol concentrations.

Side effect

Local reactions: dryness and irritation of the nasopharynx, unpleasant taste and smell, nosebleeds, burning sensation, nasal congestion; very rarely (less than 1/case) - perforation of the nasal septum (especially with a history of surgical interventions in the nasal cavity).

Allergic reactions: possible skin rash, swelling of the face and tongue; very rarely (less than 1/case) - anaphylactic reactions and bronchospasm.

Other: headache.

Very rare cases of glaucoma, increased intraocular pressure and cataracts have been reported with long-term use of fluticasone propionate, however, a cause-and-effect relationship was not identified in clinical studies lasting up to 1 year.

Indications

— prevention and treatment of seasonal allergic rhinitis;

— prevention and treatment of year-round allergic rhinitis.

Contraindications for use

- children under 4 years of age;

- hypersensitivity to fluticasone propionate and other components of the drug.

The drug should be used with caution if you have herpes, as well as an infection of the nasal cavity or paranasal sinuses. Infectious diseases of the nose require appropriate treatment. Infectious diseases of the nose are not a contraindication for the use of Flixonase.

The drug should be prescribed with caution after a recent injury to the nose or after surgery in the nasal cavity, as well as in the presence of ulcerative lesions of the nasal mucosa.

Flixonase should be prescribed with caution simultaneously with inhibitors of the CYP3A4 isoenzyme (including ritonavir, ketoconazole), since these drugs may cause an increase in the concentration of fluticasone propionate in plasma.

Caution should be exercised when prescribing the drug concomitantly with other dosage forms of corticosteroids, including tablets, creams, ointments, asthma medications, similar nasal sprays, and eye or nasal drops.

Use during pregnancy and breastfeeding

It is not recommended to prescribe Flixonase during pregnancy. If it is necessary to use the drug in this category of patients, the expected benefits of therapy for the mother and the potential risk for the fetus should be taken into account.

Use in children

For children aged 4-12 years, it is recommended to administer 50 mcg (1 dose) in each nostril 1 time/day. The maximum daily dose of the drug is 200 mcg (2 doses in each nostril). Contraindication: children under 4 years of age.

special instructions

Caution must be exercised when transferring patients from systemic corticosteroid therapy to treatment with Flixonase if there is reason to suspect adrenal dysfunction.

With long-term use of the drug, regular monitoring of adrenal function is required.

The patient should be warned that if there is no improvement after 7 days of continuous use of the drug, he should consult a doctor.

With continuous use of the drug for more than 6 months, medical monitoring of the patient's condition is necessary.

In most cases, the use of Flixonase can successfully control the symptoms of seasonal allergic rhinitis, but in some cases, with very high concentrations of allergens in the air in the summer, additional therapy may be required.

To relieve ophthalmological manifestations against the background of successful treatment of seasonal allergic rhinitis, additional treatment may be required.

Source: http://protabletky.ru/flixonase/

Flixonase

  • GlaxoSmithKline, UK
  • Expiration date: until 01/01/2020
  • GlaxoSmithKline
  • Expiration date: until 08/01/2020

Flixonase instructions for use

Buy with this product

Release form

Dosed nasal spray.

Compound

    1 dose:

— fluticasone propionate (micronized) 50 mcg

Excipients: anhydrous dextrose, microcrystalline cellulose, microcrystalline carboxymethylcellulose, phenylethyl alcohol, benzalkonium chloride solution, polysorbate 80, diluted hydrochloric acid, purified water.

Package

pharmachologic effect

FLIXONASE - gx for intranasal use. It has a pronounced anti-inflammatory, anti-edematous and anti-allergic effect.

Flixonase, indications for use

— prevention and treatment of seasonal allergic rhinitis;

Contraindications

- children under 4 years of age;

Directions for use and doses

Flixonase is intended for intranasal use only. To achieve the full therapeutic effect, the drug should be used regularly.

Use during pregnancy and breastfeeding

It is not recommended to prescribe Flixonase during pregnancy. If it is necessary to use the drug in this category of patients, the expected benefits of therapy for the mother and the potential risk for the fetus should be taken into account.

Side effects

Local reactions: dryness and irritation of the nasopharynx, unpleasant taste and smell, nosebleeds, burning sensation, nasal congestion; very rarely (less than 1/case) - perforation of the nasal septum (especially with a history of surgical interventions in the nasal cavity).

Allergic reactions: possible skin rash, swelling of the face and tongue; very rarely (less than 1/case) - anaphylactic reactions and bronchospasm.

Other: headache.

Very rare cases of glaucoma, increased intraocular pressure and cataracts have been reported with long-term use of fluticasone propionate, however, a cause-and-effect relationship was not identified in clinical studies lasting up to 1 year.

special instructions

Caution must be exercised when transferring patients from systemic corticosteroid therapy to treatment with Flixonase if there is reason to suspect adrenal dysfunction.

With long-term use of the drug, regular monitoring of adrenal function is required.

The patient should be warned that if there is no improvement after 7 days of continuous use of the drug, he should consult a doctor.

With continuous use of the drug for more than 6 months, medical monitoring of the patient's condition is necessary.

In most cases, the use of Flixonase can successfully control the symptoms of seasonal allergic rhinitis, but in some cases, with very high concentrations of allergens in the air in the summer, additional therapy may be required.

To relieve ophthalmological manifestations against the background of successful treatment of seasonal allergic rhinitis, additional treatment may be required.

Drug interactions

Due to the very low plasma concentrations of fluticasone propionate after administration of Flixonase, a clinically significant interaction is unlikely.

With simultaneous use of Flixonase with ritonavir, which is a strong inhibitor of the CYP3A4 isoenzyme, a significant increase in the concentration of fluticasone propionate in the blood plasma is possible. As a result, there is a sharp decrease in serum cortisol concentrations, and side effects due to the systemic action of corticosteroids develop, including Cushing's syndrome and suppression of adrenal function.

With simultaneous use of Flixonase with other inhibitors of the CYP3A4 isoenzyme, a negligible (with erythromycin) or insignificant (with ketoconazole) increase in the concentrations of fluticasone propionate in the blood plasma is observed, which does not cause a noticeable decrease in serum cortisol concentrations.

Check for interactions of other drugs with Flixonase

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Overdose

No symptoms of acute or chronic overdose of the drug have been recorded. When administered intranasally to healthy volunteers, 2 mg of fluticasone propionate 2 times a day. within 7 days no effect on the function of the hypothalamic-pituitary-adrenal system was detected.

Storage conditions

The drug should be stored at a temperature not exceeding 30°C.

Best before date

  • Flixonase 50mcg/dose 120dose nasal spray
  • Flixonase 50mcg 120doses
  • Flixonase 50 µg/dose 120 doses nasal spray
  • Flixonase spray called. 50mcg/dose 120doses
  • Flixonase spray called. 50mcg/dose+120doses №1

Latest reviews about Flixonase

A drug for allergic rhinitis. The only spray that really relieves symptoms and helps you breathe normally. This is not the first time I have used it. You can use it only once a day, and not as they say in the comments. This is a hormonal drug. In an advanced case, of course, it will not help right away, but if you use it in courses, you can even really make your life easier))) In any case, you should first consult a doctor!

it helps very well for a severe runny nose, the first spray completely removed the swelling of the mucous membrane for 5 hours, then you have to spray again, but the time between doses does not decrease, as with other sprays, Pinosol was enough for me for only half an hour. The bottle is convenient, but the spout is too big for small nostrils.

I had a bad runny nose, my nose was stuffy, and inhalations didn’t help. I started taking flixonase and spraying it in my nose. I was scared because it was burning inside. Then I started doing it a little at a time, the burning went away, my nose hurt, and what came out of there was simply terrible. Well, I didn’t wait until I got sinusitis.

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** Delivery is carried out only for the preferential category of citizens on the basis of Art. 2 of the Federal Law of the Russian Federation of 01/09/1997 N 5-FZ “On the provision of social guarantees to heroes of socialist labor and full holders of the Order of Labor Glory” (as amended on 07/02/2013) and Article 1.1 of the RF Law of 01/15/1993 N “On the status of Heroes Soviet Union, Heroes of the Russian Federation and full holders of the Order of Glory." All orders are placed in a pharmacy (licensed) and collected by qualified pharmacists.

Source: http://www.piluli.ru/product/Fliksonaze