Composition of the triad injection

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Threefold from temperature: composition of tablets and injections

A troika for temperature, when the thermometer readings have risen sharply, is an indispensable remedy.

It is used for colds and sore throats of infectious origin.

Table of contents:

Is this remedy suitable for everyone? What is a triad?

Doctors around the world have long argued about the effectiveness of this composition. Doctors' opinions differ sharply. Some believe that an injection given at a high temperature really helps quickly and does not harm the patient.

Other doctors claim that this composition causes great harm to the body.

What temperature should I lower?

An increase in body temperature during a cold indicates that the body has used all its resources to fight pathogenic microflora. If you immediately start lowering the temperature, the immune system will not be able to resist, and the disease will progress.

A strong immune system acts uncompromisingly and quickly. High temperatures create a hot environment in the body in which pathogenic bacteria cannot freely exist and multiply.

That's why you don't need to be afraid of temperatures up to 39. Moreover, most antibiotics begin to act actively when the thermometer is high. Therefore, at temperatures below 38.5, it is not recommended to take antipyretic drugs.

You should start taking medications to reduce fever only if the thermometer is steadily creeping up. This behavior of the body indicates that it has exhausted all its protective resources, and the heart has begun to work at the limit of its capabilities. In such a situation, a triple for temperature will be very useful.

However, there are certain conditions under which you should take an antipyretic drug already at around 38

  1. Arrhythmia.
  2. Other congenital or acquired heart defects.
  3. Fainting and convulsions are a consequence of individual temperature intolerance.
  4. Neurotic and mental disorders (for example, epileptic seizures).

Composition of the triad

Threefold fever has another name, which is used mainly by doctors - lytic mixture.

In the medical reference book it is defined as a combined composition for accelerated stabilization of normal temperature. Moreover, the lytic mixture also provides analgesic effects. That is why this injection is often simply necessary.

The classic triad has the following composition:

But today you can buy Diphenhydramine in a pharmacy only with a doctor’s prescription. Therefore, this drug is replaced with antihistamines, for which a prescription is not required:

Other components that make up the triad may also change. No-shpu is replaced by Papaverine; these drugs are very similar in their action.

How does the triad injection work?

Surprisingly, any of these remedies have nothing to do with lowering the temperature. How can they reduce high fever and improve the patient's condition?

However, this composition provides the body with invaluable assistance in the fight against pathogenic microflora. Typically, a high temperature with a cold or flu is accompanied by the following symptoms:

The components included in the injection cope perfectly with all these problems.

  1. Analgin will relieve pain.
  2. No-Shpa (Drotaverine) or Papaverine will eliminate spasm of blood vessels, which will relax and expand.
  3. An antihistamine will save the tissues from swelling.

When medical scientists noticed that the combination of these medications effectively lowered body temperature, the composition began to be used in emergency cases.

Contraindications and features of use of the composition

Troychatka also has contraindications for high fever. The lytic mixture is not used if:

  • the patient has cutting or acute wandering pain in the abdomen, which may be evidence of appendicitis;
  • the patient has an allergic reaction to any component of the triad;
  • Before the injection, the patient has already taken a drug that contains Analgin - an overdose of this medicine is very dangerous.

It has already been said above that taking triad is recommended only in emergency situations. The highest bioavailability of the drug is ensured with intramuscular injections.

Typically, an injection is given in cases where the patient’s condition is critical (the temperature rises relentlessly), and it is not possible to deliver him immediately to a medical facility.

This composition for fifteen minutes:

  1. normalizes temperature;
  2. will prevent the development of an allergic reaction;
  3. relieves associated pain.

In case of serious illness, the fever may, of course, rise again after 1-2 hours. However, the patient will have this saving time, during which the ambulance team will definitely arrive and take him to the hospital.

Instructions for the introduction of triad

  • In order to warm the drugs, you need to hold the ampoules in your clasped palm.
  • Before injection, ampoules must be disinfected with a cotton swab soaked in alcohol.
  • First, 2 ml of Analgin is drawn into a disposable syringe.
  • Next, 2 ml No-shpa.
  • Lastly, 1 ml of antihistamine is taken.
  • An intramuscular injection is made into the buttock, more precisely into its outer upper square. But first, the skin in this place must be wiped with alcohol.
  • The needle insertion should be strictly perpendicular to the surface of the buttock.
  • When the needle enters the skin 2/3 of the way, slowly begin to inject the mixture.
  • If a lump is found at the injection site a little later, an iodine mesh should be applied to this area.

Recommendations for the use of Analgin in the triad

Analgin exhibits its antipyretic properties well in tablet form; for this reason, it is used quite rarely in the form of an injection solution. The injection should be made only into muscle tissue, while slowly pressing on the syringe plunger.

The maximum daily dose of the drug should not exceed 2 ml. If the medicine is administered very quickly, it can cause a sharp drop in blood pressure.

Injections with this drug are prohibited for:

  1. pregnant and lactating women;
  2. people who have individual intolerance to Analgin;
  3. patients suffering from pathologies of the hematopoietic system.

But maybe the triad has an alternative? Without a doubt. If the patient has contraindications or there is simply no one to give him an injection of the lytic mixture, a combination of the same three drugs in the form of tablets can be used.

This combination will provide the same effect on the body as the triad solution. An adult patient can improve his condition by taking Baralgin, No-shpa (Papaverine) and Diazolin (Suprastin) at the same time.

At high body temperatures, some folk remedies help well. An adult patient can use the following methods:

  • rubbing with vinegar or vodka solution;
  • wraps with wet sheets;
  • rubbing at temperature with vinegar;
  • cold compresses on the wrists and temples.

In fact, there are a lot of similar folk remedies, but more on that in another topic. In addition, the video in this article will tell you. How can you prepare a trio yourself?

Source: http://stopgripp.ru/lechim/preparat/trojchatka-ot-temperatury.html

Instructions for the use of triad at high temperatures for children and adults - combinations of drugs

Among doctors, this medication is considered a universal way to quickly get rid of fever symptoms if necessary. Troikatka for fever is a remedy that is a mixture of three drugs; when interacting, they help to effectively cope with influenza, acute respiratory viral infections and other inflammatory diseases. Can be used in tablet form or intramuscular injection.

What is a triad

The product is also called a lytic mixture; with the correct proportion of constituent substances, it is possible to quickly normalize high body temperature and overcome associated symptoms. An experienced doctor can replace one or two components of the triad. Sometimes Analgin is replaced with any other antipyretic drug, Suprastin can be replaced with Diazolin, and Papaverine can be replaced with Drotaverine, No-shpu or Paracetomol. Conducting experiments on your own is strictly not recommended, because it is important to take into account the peculiarities of drug interactions.

Compound

The components of the medication may change depending on the individual characteristics of the patient (intolerance or allergy to drugs). Such a pronounced positive effect is formed from the totality of the properties of all ingredients. What is included in the triad of temperature in the classic version:

  1. No-shpa. The active ingredient of this medication is drotaverine, which is derived from isoquinoline. It has a high antispasmodic effect on smooth muscles and produces the effect of inhibiting the phosphodiesterase enzyme. The latter takes part in the hydrolysis of cAMP and AMP.
  2. Analgin. Metamizole sodium in the drug is a pyrazolone derivative. The drug has a weak analgesic, antipyretic, and anti-inflammatory effect. The mechanism of action is associated with inhibition of prostaglandin (PG) synthesis. Minutes after consuming the medication, the pharmacological effect develops. The maximum effectiveness of the component occurs after 2 hours.
  3. Diazolin. Acts as a blocker of H1-histamine receptors. Helps reduce swelling of the mucous membranes and has an antiallergic effect. As part of the triad, this medication helps to weaken the effect of histamine on the smooth muscles of the intestines, bronchi, and uterus, reduce the severity of hypotension, and increase vascular permeability. The medication penetrates well into the central nervous system, and it does not have a sedative or hypnotic effect. Has weak M-cholinergic, anesthetic properties. The effect of use occurs within 30 minutes and can last up to 2 days.

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pharmachologic effect

Troikatka is recognized by all doctors as an effective remedy against fever when it is necessary to quickly reduce fever. Each component in the product has its own pharmacokinetics. Preparations from which the triad is prepared:

  1. Analgin. Capable of being quickly and completely absorbed immediately after oral use. There is no unchanged metamizole in the blood, the drug is excreted by the kidneys. It must be taken into account that metabolites may be excreted in breast milk. The drug is completely eliminated from the body along with urine.
  2. No-shpa. Absorbed completely from the gastrointestinal tract when used in tablet form. During the first filtration through the liver after metabolism, 65% of the drug enters the systemic circulation. After an hour it reaches plasma.
  3. Diazolin. The medication is absorbed through the gastrointestinal tract relatively quickly, the drug immediately enters the body tissues. The bioavailability of diazolin can be in the range of 40-60%. The plasma half-life occurs within 4 hours and practically does not penetrate the blood-brain barrier. Processed by the liver and excreted by the kidneys.

Indications for use

This remedy can be used in all cases for children or adults if necessary to reduce fever. Troikatka at a temperature effectively fights inflammatory processes, flu or seasonal colds. In addition, the mixture helps to truly fight other infectious diseases. It is not recommended to lower the temperature if it has not risen above 38 degrees. The environment that is created under such conditions is not liked by pathogenic bacteria, which leads to a stop in their reproduction and death.

It is imperative to bring down the temperature with the help of a triad or another remedy if you have:

  • frequent convulsions, fainting;
  • heart defects;
  • mental, neurotic disorders;
  • arrhythmia.

How to make a triad

Only a doctor who can accurately calculate the proportions should prepare this medication against temperature. Troychatka is a serious and potent drug that should not be taken without a reason. The medication is prescribed in emergency cases, when there is a need to quickly and effectively reduce the temperature. Separately, it is necessary to take into account what has already been taken by the patient; repeated use of analgin can lead to an overdose.

Triad of tablets

If it is necessary to quickly bring down a high temperature, only a specialist can prepare the correct mixture of medications. For this, three tablets are used, which must be compatible with each other; in some cases, analogues are selected. For example, instead of Papaverine, Paracetamol is used, Diphenhydramine is replaced with Suprastin or Diazolin. Often problems arise due to analgin (it cannot be used during pregnancy or has already been taken previously), it is changed to any other painkiller. It is necessary to be especially careful when creating a triad when treating a child.

Method of using troika for temperature

This is a serious drug that is important to take carefully; negligence can lead to side effects and complications. The triad injection is carried out according to the following proportions:

  • antihistamine (Diphenhydramine/Diazolin) – 1 ml;
  • Papaverine/No-spa – 2 ml;
  • Analgin – 2 ml.

If you decide to go with the tablet version, then maintaining the proportions to combat the temperature is much easier. An adult should take one pill of each product. Drink plenty of water. Three tablets for fever cannot be given to a child; the dosage must be selected based on the patient’s weight. It is necessary to take into account that a triad injection or taking tablets for fever can be carried out no more than 3 times a day.

Dosage for adults

It is not recommended to take triad to combat fever on your own; a doctor should prescribe the remedy. Before taking it, it is recommended to consult a specialist. He will be able to advise you on the form of administration (triad solution or tablets). The injection will bring relief to the patient in 20 minutes, the pills will begin to act after 30 minutes.

The optimal dosage is selected taking into account the patient’s weight. For a person weighing 60 kg, a solution is prepared in a ratio of 1:1:1 ml of all components. When using tablets, you must read the instructions for all medications; as a rule, 1 pill of each drug is enough. It is not recommended to exceed the prescribed doses of triad, as an overdose may occur. The high temperature may return, but you should not take the fever medicine more than 3 times.

For children

Only a doctor can prescribe this medication to a child. A troika for children from temperature can be dangerous if the ratio and number of components are incorrectly calculated. A specialist will be able to choose the right analogues if the child has an allergy or intolerance to one of the ingredients of the triad. Medical professionals strongly discourage parents from self-medicating high fevers with this remedy. The dosage is calculated based on the patient's weight. You can give a triad injection only if your temperature rises sharply and you are unable to call a doctor.

How to give an injection correctly

It is better if a specialist performs the triad injection. If there is an urgent need to get an injection before the doctor arrives, you can use the following instructions to bring down the temperature:

  1. Take the medicine ampoules and hold them in your palms to warm them.
  2. Disinfect with a cotton swab and alcohol before injecting the ampoule.
  3. Fill a disposable syringe with 2 ml of Analgin.
  4. Next, take 2 ml of No-shpa.
  5. Lastly, 1 ml of antihistamine is taken.
  6. An intramuscular injection is necessary in the upper lobe of the buttock. At this point, wipe the skin with a cotton swab and alcohol.
  7. The needle must be inserted strictly perpendicular to the surface of the muscle.
  8. Insert the needle 2/3 of the way in, slowly begin inserting the triad.
  9. If a lump appears at the injection site, it must be lubricated with iodine (mesh).

Use of triad for temperature during pregnancy

It is not recommended to use this medication while carrying and feeding a child. This is due to the Analgin included in the composition, which can cause side effects and can penetrate into the composition of milk. It is recommended to replace it with a drug from the group of NSAIDs (non-steroidal anti-inflammatory substances), which are allowed to be taken by pregnant women. Only a specialist doctor can select the correct components.

Contraindications

The product belongs to the group of potent ones, so it is better to use it after consulting a doctor. Troychatka for temperature is contraindicated in the following cases:

  1. Allergy to one of the ingredients of the mixture.
  2. Sharp, cutting, wandering pain in the abdomen. This may be a sign of appendicitis.
  3. If, before taking the lytic mixture, analgin or a drug that contains it was already used. This will lead to a high risk of overdose.
  4. Lactation period, pregnancy.

Overdose

If all doctor's instructions are followed, this medication is safe for human health. The recipe includes analgin, which often causes an overdose. As a rule, after this the following symptoms occur:

Video

The information presented in the article is for informational purposes only. The materials in the article do not encourage self-treatment. Only a qualified doctor can make a diagnosis and make recommendations for treatment based on the individual characteristics of a particular patient.

Source: http://sovets.net/12590-trojchatka-ot-temperatury.html

Analgin + Diphenhydramine + Papaverine

Combination of diphenhydramine with analgin and anti-allergy drugs

Diphenhydramine and papaverine remain the most commonly used drugs, which is associated with the low cost of drugs and the rapid onset of effects. Moreover, along with them, analgin is used, which is part of the “triad” injection. This mixture is used in a medical hospital and in the emergency department. The “triad” is administered intramuscularly, which allows the onset of the desired effect to be accelerated.

The “triad” is used in surgical, trauma, and therapeutic patients. The injection composition, due to analgin, has a mild analgesic effect and is also effective against fever. Diphenhydramine is a blocker of histamine receptors in the periphery and is used as a central sedative. Papaverine is a strong antispasmodic with a predominant effect on vascular smooth muscle.

The combination of drugs in the “triad” is considered universal for providing first aid in the case of many pathologies. For surgical diseases, papaverine with diphenhydramine and analgin helps relieve pain by relaxing the muscles of the ducts, areas of the urinary tract and intestines. Due to diphenhydramine, it is possible to significantly alleviate the symptoms of acute surgical, urological and gynecological pathologies. It helps to calm the patient. Analgin can replace aspirin if it is available in the form of an injection solution.

In a therapeutic hospital and in the emergency department, in an ambulance and in paramedic and obstetric centers, the “troika” can be used to relieve a hypertensive crisis and to relieve anxiety. Papaverine is used to lower blood pressure in the triad. It very gently corrects blood pressure by relaxing muscular arteries. They are located on the periphery, which means that the action of papaverine improves blood supply to peripheral tissues without disrupting blood flow in the brain, kidneys, and heart.

In most regions of the country there are no large hospitals with special allergy departments. As a result, patients with allergic diseases are admitted either to therapeutic hospitals or to the intensive care unit. However, the first stage of their hospitalization is the emergency room or emergency room. Here, the “troika” can be used to reduce the activity of the allergic reaction. Due to the presence of diphenhydramine, the mixture reduces the risks for the patient in case of a systemic allergic reaction.

Composition of the triad, dosage of drugs

The triad contains three pharmacological drugs, which are extremely cheap, have a relatively small number of side effects, and also have a rapid onset of effect. These include analgin, diphenhydramine and papaverine.

The dosage of analgin in the mixture is 2 ml of a 50% solution. The dose of diphenhydramine is 1 ml of a 1 percent solution. Papaverine dosage – 2 ml – 2% solution.

The drug analgin is not used in Western countries due to the large number of adverse reactions and because it is not economically profitable for pharmaceutical companies. It belongs to the class of non-steroidal anti-inflammatory drugs and has many analogues. One of them is aspirin. Both drugs have many adverse reactions associated with inhibition of 2 types of cyclooxygenase. However, to reduce fever, analgin and aspirin remain excellent means.

The drug diphenhydramine belongs to the class of histamine receptor inhibitors and is listed among the first generation drugs. In fact, diphenhydramine is already outdated and is not the most effective for the treatment of allergic diseases. This is due to the suppression of nervous activity at the highest level. After taking diphenhydramine, the vast majority of patients experience drowsiness. For this reason, the “troika” is not an effective means of permanent treatment of allergies, although it can be used at the initial stage of development of a systemic reaction: urticaria, anaphylactic shock, angioedema.

A full-fledged analogue of diphenhydramine that does not have a central effect is loratadine, known under the trade name Claritin. This drug belongs to the class of second generation histamine blockers. In the same category for the treatment of allergies there is fenkarol, peritol, diazolin, simplex. The most effective at the moment are representatives of the third generation of histamine receptor blockers: cytirizine, desloratadine, fexofenadine. Moreover, loratadine remains one of the most commonly used drugs for the treatment of all types of allergies.

Papaverine, as part of the triad, acts as an antispasmodic agent, which is most active in relation to the vascular muscles. An intramuscular injection leads to a decrease in blood pressure, relaxation of the smooth muscles of the intestines, the sphincter of the gallbladder, the major duodenal papilla, and the ureter. Moreover, the functional analogue of papaverine is “No-shpa”.

This drug contains drotaverine, which is more active against the smooth muscles of internal organs rather than blood vessels. No-spa is used in surgical, therapeutic and gynecological practice. Due to the relaxation of smooth muscles, drotaverine and papaverine are able to relieve pain. They are not superior to novocaine in terms of potency, but they eliminate the cause of pain, which is why they are chosen for treatment much more often than other drugs.

Author of the article: Alina Samsonova

Source: http://myallergiya.ru/lechenie/trojchatka.html

Triad injection: description and properties of the medication

High temperature can accompany a variety of diseases and pathological conditions. The temperature can rise in both adults and children.

Doctors recommend lowering the temperature exclusively to 39 and 40 degrees.

Today there are a large number of medications that help reduce fever. However, the most effective drug for reducing fever is the triad injection.

The drug, as the name suggests, has several effects. This unique remedy helps in the fight against inflammatory diseases, as well as pathologies such as influenza or ARVI. The medicine is much more effective than various tablets, since its effect is combined compared to other medications.

Troychatka (Analgin, Diphenhydramine, Papaverine) is also called a lytic mixture. Often the product is used for injections. This remedy is a combination remedy, it helps not only to lower the temperature, but also to eliminate pain.

Often, troika is used by emergency doctors when making house calls to reduce the temperature, as well as to eliminate malaise in people who are being treated in a hospital. Composition of the drug: Analgin, Diphenhydramine and Papaverine (Drotaverine).

In some cases, Drotaverine is replaced with No-shpa. And since Diphenhydramine is available only by prescription, Tavegil or Diazolin is used instead. Triad injections are often given, since it is thanks to the intramuscular injection of the drug that the therapeutic effect occurs in about 15 minutes.

The therapeutic properties of the drug are determined by its components. Analgin has an analgesic effect and helps reduce fever. As for Diphenhydramine, this drug helps block histamine receptors and also has a sedative effect. As for Papaverine, this drug has a positive effect on vascular smooth muscle and helps eliminate spasms.

Thanks to this combination, the drug is a real salvation, capable of providing emergency assistance to people suffering from various pathologies, and also helping to reduce temperature.

In addition, the triad injection is used quite often in cases of hypertensive crisis, as it helps in lowering blood pressure, with depressive and anxiety disorders, with painful sensations caused by spasms of the intestines or genitourinary system, the drug is also effective for back pain.

Triple injections are certainly effective and will help reduce fever in both adults and children. However, it is not recommended to use this combination of drugs without the knowledge of a specialist. In addition, it is very important to observe the proportions at the time of preparing the solution, and the dosage at the time of use.

Troychatka (injection for temperature): composition, indications and contraindications

The composition of the triad for temperature includes: Drotaverine (No-shpa or Papaverine), Diphenhydramine (Diazolin or Tavegil) and Analgin. This is a very effective remedy against inflammatory diseases, influenza, and acute respiratory viral infections.

A troika (injection for fever) can only be prescribed by a qualified specialist.

Self-medication, as well as using a composition with incorrect proportions, is fraught with disastrous consequences.

Doctors often prescribe the use of a lytic mixture to lower the temperature, regardless of what caused its increase. A competent combination of three separate medications helps to quickly stabilize the temperature, eliminate painful joints and eliminate headaches.

However, when giving injections of triad for fever in a child, do not forget that for diseases of an inflammatory nature, the duration of action of the drug is 3-4 hours. After this, the fever may return. Due to the heavy load on the children's body, it is recommended to administer the drug no more than three times a day.

You should also not forget, especially if a small child suffers from high fever, that the use of a lytic mixture can only be prescribed by a specialist.

However, if the child’s temperature does not decrease, and for some reason it is impossible to call a doctor at home, in order to prevent seizures, which can lead to disastrous consequences, in particular death, you need to keep medications at home in order to give a triad injection for fever in time.

The recipe for preparing the mixture is quite simple, the main thing is to strictly observe the proportions of the components. The lytic mixture consists of three main drugs. If the required drug is not at hand, it can be replaced with another, but with the same effect.

Troychatka (Analgin, Paracetamol, Suprastin) is effective in combating fever in both children and adults. Paracetamol is identical in properties to Papaverine and Drotaverine, and Suprastin is identical to Diphenhydramine. Analgin, if it is not available at home, can be replaced with any medication that has an analgesic effect.

The dose of the mixture depends on the patient’s body weight. If the weight is less than 60 kg, the product is prepared as follows: 1 ml of Analgin, 1 ml of Papaverine and 1 ml of an antihistamine, for example, Diazolin. The drug will take effect after about a quarter of an hour.

To get the most benefit from a medicine, it is important to know how to use it. Before filling the syringe with the product, the ampoules of the three medications must be squeezed in your hands to warm them up. You should also not forget about disinfecting the ampoules before administering the injection. The next stage is filling the syringe with the components of the triad. First you need to take two milliliters of Analgin, then the same amount of Paracetamol, and one milliliter of an antihistamine.

The place for intramuscular injection of the lytic mixture is the upper outer square of the buttock. Before giving the injection, it is necessary to treat the dermis with alcohol. Then you need to insert the needle 2/3 of the way (perpendicular to the surface of the buttock), and then slowly introduce the solution. If a lump has formed at the injection site, it is necessary to apply an iodine mesh.

Troychatka (injection for fever), not recommended for use for cutting, sharp or wandering painful sensations in the abdomen.

These manifestations may indicate appendicitis. The use of the product is contraindicated for people with individual intolerance. Pregnant and breastfeeding women should not use this combination.

The lytic mixture is a rather serious medicine, which, if used inappropriately, can cause disastrous consequences.

It can be used exclusively in extreme cases and only when there are no contraindications to its use: with severe intoxication of the body, accompanied by nausea, vomiting and diarrhea, a critical increase in temperature and the inability to bring it down with the help of antipyretics.

Inappropriate use of a combination medication, as well as non-compliance with dosages and proportions and abuse, can lead to dehydration, convulsions, dizziness and loss of consciousness.

In order to prevent the occurrence of side effects and worsening of the condition, before giving the injection, you should consult a specialist.

Specialty: Otorhinolaryngologist Work experience: 29 years

Specialty: Audiologist Work experience: 7 years

Source: http://gajmorit.com/gripp/ukol-trojchatka/

Troychatka from temperature

Even professional doctors call this remedy a universal “first aid” and recommend using it if your body temperature has risen above 38 degrees. The troika for temperature helps to cope with acute respiratory viral infections, influenza, and inflammatory diseases.

Indications for use

In fact, this remedy can always be used if an adult or child has a fever due to an inflammatory process, seasonal cold or flu. In addition, the triad for temperature is truly indispensable for other infectious diseases.

Today, there are many opinions about the effectiveness of this drug. Some people consider it indispensable, while others, on the contrary, think that it is more harmful than useful. In any case, if your body temperature rises to 38 degrees, do not rush to bring it down. The fact is that thanks to it, a hot environment is created in the body, which pathogens do not like. Harmful bacteria stop multiplying and die immediately if the patient’s body temperature rises to 38.5 degrees. In addition, some medications work more effectively only in this condition of the body.

It is necessary to bring down a high temperature: for congenital and acquired heart defects, if you have frequent fainting or convulsions, arrhythmia, for neurotic or mental disorders (epilepsy).

Release form

Doctors also call triad a lytic mixture. Usually a solution is used for injection, but you can also take tablets. Lytic mixture means that this drug is a combination remedy that helps quickly stabilize normal body temperature. Triad also has an analgesic effect.

Pharmacodynamics

The classic version of the triad includes three main components: Analgin, No-shpa and Diphenhydramine. Therefore, we will consider the pharmacodynamics of each of them.

  1. Analgin . It contains metamizole sodium, which is a derivative of pyrazolone. The drug has a weak antipyretic, analgesic, and anti-inflammatory effect. Its mechanism is associated with inhibition of PG (prostaglandin) synthesis. Minutes after taking the drug, its pharmacological effect develops. Maximum effectiveness is achieved after two hours.
  2. No-shpa . The active ingredient is drotaverine, which is a derivative of isoquinoline. It has a powerful antispasmodic effect on smooth muscles due to inhibition of the phosphodiesterase enzyme. The latter is necessary for the hydrolysis of AMP and cAMP.
  3. Diazolin . The drug is an H1-histamine receptor blocker. It has an antiallergic effect and helps reduce swelling of the mucous membranes. Using this remedy, you can weaken the effect of histamine on smooth muscles, uterus, bronchi and intestines, reduce the severity of hypotension, and increase vascular permeability. Penetrates slightly into the central nervous system, but does not have a hypnotic or sedative effect. Anesthetic and M-cholinergic properties are weakly expressed. The effect is achieved within minutes after administration. Its duration can last up to 2 days.

Pharmacokinetics

Let's consider the pharmacokinetics of each drug that is part of the classic triplet recipe.

  1. Analgin . Completely and quickly absorbed immediately after oral administration. There is no unchanged metamizole in the blood. The drug is excreted by the kidneys. In this case, metabolites can be excreted in breast milk. Completely excreted in urine.
  2. No-shpa . Completely absorbed from the gastrointestinal tract after oral administration. But after metabolism during the first passage through the liver, 65% of the drug can enter the systemic circulation. After a minute it reaches the plasma.
  3. Diazolin . Due to the fact that the drug is absorbed quite quickly through the gastrointestinal tract, diazolin immediately penetrates the body tissues. Its bioavailability can range from 40% to 60%. The plasma half-life is 4 hours. It practically does not penetrate the blood-brain barrier. Metabolism takes place in the liver. The drug is excreted by the kidneys.

Use of triad for temperature during pregnancy

During pregnancy and lactation, you should not take troika for fever. This is explained by the fact that it contains Analgin. In this case, it is necessary to look for a suitable alternative. For example, the use of three different drugs in tablet form (Suprastin, No-Shpa and Baralgin) is excellent. It is also worth consulting with a doctor who will prescribe effective therapy that is safe for the health of the expectant mother and fetus.

Contraindications for use

In what cases should the lytic mixture not be used?

  1. Cutting or wandering pain in the abdominal area. This may be one of the symptoms of appendicitis.
  2. Individual intolerance to at least one of the components of the triad.
  3. If the patient has already taken any analogue of Analgin before the injection. This may lead to an overdose.
  4. Pregnancy and lactation.

Triad composition depending on temperature

As mentioned above, troika for temperature is a combination drug. The classic composition of this remedy includes: No-shpa (in particular, the component drovaterin), diphenhydramine and analgin. But today, most manufacturers are trying to replace diphenhydramine (which can only be bought with a doctor’s prescription) with other antihistamines (Suprastin, Tavegil, Diazolin). In some cases, other components of the triad are also replaced. For example, No-shpa is often replaced by Papaverine, which has a similar effect.

An interesting fact is that all the drugs that are part of the triad, in fact, do not have an antipyretic effect, but together they help reduce body temperature to normal levels. Why is this happening? These products help your immune system fight bacteria. As a rule, at high temperatures, joints ache, pulse quickens, and headaches. Troychatka, with the help of its components, copes with these symptoms (analgin will relieve pain, papaverine or no-spa will relieve spasm of blood vessels and dilate them, diazolin will relieve tissue swelling).

Troychatka from temperature for children

Diseases that cause fever are common in both adults and children. Children tolerate fevers worse. And, although many doctors do not recommend lowering the temperature to 38 degrees, parents often do this.

In such cases, a temperature three for children is very often used. In its composition, it is no different from the classic one (analgin, papaverine or no-spa and any antihistamine). In what cases can such a drug be prescribed to a child and how safe is it?

Doctors often prescribe intramuscular administration of triad to reduce high body temperature, regardless of what caused it (viral or bacterial infections). If you choose the right proportions, the combination of three separate drugs will help to quickly stabilize the temperature, relieve pain in the joints, and overcome headaches. But, if you give a triad injection to a child, you should remember that during inflammatory processes it helps to relieve the temperature only for three to four hours, after which the fever appears again. Due to the heavy load on the child’s body, triad can be administered no more than three times a day.

Remember, only a doctor can prescribe a fever test, especially if fever appears in young children. The danger lies in the fact that parents may choose the wrong dosage of drugs. If your child has a fever, you should call a doctor immediately and not self-medicate.

However, there are times when the baby has a high body temperature, and it is not possible to call a specialist. To prevent the occurrence of seizures, which can cause death, you must always keep a prepared triad or at least the drugs that are part of it (in any form) in your home medicine cabinet.

If your child is afraid of injections, you can make a microenema from the components of the triad, which will take effect within 5-10 minutes. But you should not abuse this remedy.

How is a triplet done based on temperature?

It is worth understanding that triad is a rather serious drug that should not be introduced into the body just like that. It is prescribed only in emergency cases when it is necessary to quickly bring down the temperature.

Recipes

Only a competent specialist can make the correct three-piece, which will help bring down the high temperature in your particular case. The thing is that triad is made from three main components, which can be replaced with other drugs with a similar effect. For example, if Papaverine is not at hand, it can be replaced with Paracetamol, and Diphenhydramine with Suprastin or Diazolin. Analgin can be easily replaced with any painkiller. Sometimes only a doctor can choose effective remedies, especially when it comes to treating a child.

Triad dosage depending on temperature

First of all, you need to remember that the triad can only be used if the temperature has risen above 38 degrees. The injection will help you feel relief within 20 minutes; when taking tablets, you will need to wait up to 40 minutes.

The dosage of troika according to temperature always depends on the patient’s weight. If it is kg, you can make the drug with 1 ml of Analgin, 1 ml of Diazolin and 1 ml of Papaverine (No-Shpa). If you decide to take pills, you must carefully study the instructions for them.

Remember that after three to four hours the temperature will begin to increase again, but the triad should not be used more than three times a day.

Method of using troika for temperature

How to properly introduce triad into the body?

  1. The ampoules of the three drugs should be squeezed in the palms of your hands to warm them up a little.
  2. Disinfect the ampoules before administering the injection.
  3. Using a disposable syringe, you must first inject 2 ml of Analgin, then 2 ml of Papaverine and 1 ml of an allergy auxiliary substance (for example, Diazolin).
  4. The best place for an intramuscular injection is the outer upper square on the buttock. Treat the skin in this area with alcohol.
  5. The needle should be inserted strictly perpendicular to the buttock.
  6. Slowly introduce the mixture when the game enters the skin 2/3 of its length.

Using tablets is even easier. You just need to take each tablet separately with a sufficient amount of water.

Overdose

An overdose of triad can only occur if four hours before the injection the patient has already taken a drug similar to Analgin.

Storage conditions

First of all, the triad must be stored out of the reach of small children. It should be dark, without direct sunlight. If you are not going to use the drug in the near future, you need to put it in a cool place.

Best before date

Typically, the shelf life of triad depending on temperature is 2 years. You should not use the drug after this period has expired, as this may cause an unexpected reaction from the body and side effects.

Medical Expert Editor

Portnov Alexey Alexandrovich

Education: Kiev National Medical University. A.A. Bogomolets, specialty - "General Medicine"

Attention!

To make information easier to understand, these instructions for use of the drug “Troichatka for temperature” have been translated and presented in a special form based on the official instructions for medical use of the drug. Before use, read the leaflet included directly with the medication.

The description is provided for informational purposes and is not a guide to self-medication. The need to use this drug, the prescription of the treatment regimen, methods and doses of the drug are determined solely by the attending physician. Self-medication is dangerous for your health.

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Troychatka from temperature: composition

Elevated temperature or fever is the body’s protective response to the pathogenic state of excitable structures. If the general condition is satisfactory, and this means that there are no convulsive phenomena or cardiovascular diseases, in such cases it is not recommended to reduce the temperature to 38.5 degrees, the body is able to overcome the infection on its own, with the exception of small children. In cases where there is a rise in temperature, medications will be needed. The triad can help with temperature almost instantly. The composition is a mixture of three medicinal components that successfully help in the treatment of influenza, ARVI and other inflammatory processes. In combination, such substances act together very gently.

What is a triad

Properly selected components will help to quickly reduce body temperature and relieve side symptoms. A competent doctor from the triad can change one or two components. So, among the antipyretic components, analgin is often replaced with another drug that lowers the temperature, Diazolin can be a replacement for suprastin, and Drotaverine is used instead of Papaverine. The patient himself should not conduct the experiments, since only the doctor knows the pharmacological effect of the drugs.

This is a potent mixture consisting of 3 active, combined components, in medicine it is called a lytic mixture. Its mission is to quickly eliminate a patient’s fever, which comes in the form of tablets or injections.

Troychatka from temperature: composition, how the drug works:

The doctor, taking into account the individual characteristics of the patient for allergies and drug intolerance, can change the components of the mixture. The commonality of the properties of all components is what produces the positive effect.

What is included in the temperature triad in the classic recipe:

  1. No-spa contains the active substance Drotaverine, derived from isoquinol, which can have an antispasmodic effect on smooth muscles.
  2. Analgin - relieves pain, fever, relieves joint pain, muscle aches, and has an anti-inflammatory effect. After taking the drug, the positive effect appears within half an hour, and the maximum pharmacological effect is observed after a few hours.
  3. Diazolin - blocks histamine endings, helps get rid of swelling of the mucous membranes, has anti-allergic and slightly anesthetic properties. As part of the mixture, this component affects the weakening of the smooth muscles of the intestines, uterus, bronchi, the severity of hypotension decreases, and vascular permeability improves. The drug is absorbed by the central nervous system and does not cause drowsiness. The drug has its effect after half an hour, the effect lasts up to 2 days.

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For children, dosage

There will be no harm to the child's body if the temperature troika is used in the exact dosage. The composition for children, the proportions must be calculated accurately and correctly. If a child’s illness is severe, the body will tolerate this drug under enormous stress. Troychatka for fever for children is approved for use no more than three times a day.

Children are often afraid of injections and experience a painful fear of injections; in such cases, you can use a special enema prepared on the basis of diphenhydramine and analgin. Although this injection is effective, it is often not recommended.

In addition to the injection, the product for children can be used in the form of a tablet in the correct dosage.

Adults in tablets and injections, dosage

You should not lower your temperature on your own; the drug should be recommended by a doctor, and you should definitely consult with him about the use of the medicine. The doctor must give a recommendation in what form it is better to take the medication (in solution or tablet).

The triad injection has an effect after 20 minutes, the tablet form begins to work in about half an hour. In addition, dosage calculations must take into account the patient's weight. If the patient weighs 60 kg, the injection is calculated as follows: all ingredients are taken in the same proportion one to one.

When using tablets, you should carefully read the instructions included with all medications; most often, 1 tablet of each ingredient is sufficient. There is no need to increase the prescribed dosage of triad, as this can lead to an overdose. During illness, fever often recurs, but using tablets more than 3 times a day is prohibited.

Indications for use

This lytic mixture is used for children or adults in a number of cases if there is a need to lower the elevated temperature. The troika from temperature for adults and children is able to cope with inflammatory phenomena, flu or colds. In addition, the mixture treats various infectious diseases well.

You should not try to reduce the temperature if it has not risen above 38 degrees. Pathogenic microorganisms cannot tolerate the environment that arises under these circumstances; they stop multiplying and die.

To reduce the temperature using the triad, you should:

  • with incessant cramps,
  • fainting,
  • for heart problems;
  • for nervous and mental disorders.

How to prepare a triad

Only a specialist knows how to correctly formulate the proportions for preparing medicine to reduce fever. The components of the mixture have solid and significant properties that are unreasonably dangerous to use. The drug is used in emergency cases when it is necessary to reduce the temperature quickly and effectively. It is necessary to take into account which drugs the patient has already used before, because taking analgin a second time leads to an overdose.

The doctor prepares the correct components from tablets that can reduce fever, for which 3 pills are taken, their compatibility is taken into account, and in some cases analogues are used. Analgin is replaced more often, since this drug is not used by pregnant women. Also, the drug may have already been taken before, then it is replaced with another painkiller component. Particular care should be taken when composing triads when treating children.

Method of use at temperature

This is a serious medication that should be used with caution; careless use can cause side effects and harm the body.

When using the method of administration in tablet form, it is easiest to maintain the proportions to reduce the temperature for an adult patient. He will need 1 tablet of each ingredient, all medications must be washed down with sufficient quantity of water.

It is dangerous to use three tablets to reduce fever in children; the dose should take into account the patient’s weight.

Triad injection, composition:

We recommend in the following ratios: diphenhydramine (diazolin) - 1 ml; papaverine (no-shpa) - 2 ml, analgin - 2 ml.

How to give a troika injection for fever

It is advisable to entrust the triad injection to medical personnel. If there is an emergency need for an injection to reduce fever before an emergency visit, you can follow the following instructions:

  1. Hold the ampoules with medicines in your hands, they should warm up a little.
  2. Wipe off medications with a cotton swab and alcohol before injecting.
  3. Draw 2 ml into a disposable syringe. analgin, then 2 ml. no-shpy, at the end there is a histamine component.
  4. The injection is performed in the upper part of the buttock, the needle is inserted exactly at a right angle to the surface of the body. As soon as the needle has entered 2/3 of its length, slowly inject the medicine. If a lump or lump forms at the injection site, an applied iodine mesh helps a lot.
  5. The injection site is wiped with a cotton swab soaked in alcohol.

Using triad during pregnancy

This drug is contraindicated during pregnancy and breastfeeding due to side effects; it contains analgin, which passes into mother's milk. Doctors advise replacing this component with non-steroidal anti-inflammatory drugs; they can be used by pregnant women. All correctly selected components of the triad are the competence of the doctor.

Contraindications

Only after receiving competent advice can you take this potent medicine.

Triad is contraindicated for temperature if:

  • there are allergic manifestations to any of the components;
  • there are unexplained pains in the gastrointestinal tract (suspicion of appendicitis);
  • there has already been prior use of analgin, or a component containing it, which can lead to an overdose;
  • breastfeeding, pregnancy.

Overdose

The presented medicinal product will be safe if you follow all the specialist’s recommendations. The cause of overdose in most cases is analgin, which can provoke:

nausea and vomiting,

Let's watch a video on how to lower the temperature and with what.

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