Isofra composition

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Isofra spray: instructions for use

Isofra spray is an antibiotic for the local treatment of acute and chronic sinusitis.

Used in otolaryngology. Has bactericidal properties. Active against pathogens localized in the upper respiratory tract.

Table of contents:

On this page you will find all the information about Isofra: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Isofra spray. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibacterial drug for topical use in ENT practice.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

How much does Isofra cost? The average price in pharmacies is 300 rubles.

Release form and composition

The medicine Isofra for the runny nose and some other infections of the ENT organs is available in the form of a spray. The manufacturer, the French pharmaceutical company Laboratoires Bouchara-Recordati, offers the medicine in 15 ml plastic bottles with a spray dispenser, additionally packaged in cardboard boxes.

The drug contains the active ingredient framycetin in an amount of 12.5 mg per milliliter, as well as auxiliary components: distilled water, citric acid, sodium chloride and citrate, methylparaben. The average cost of one package in pharmacies is 300 rubles.

Pharmacological effect

Isofra has a bactericidal effect, that is, destructive to pathogenic microorganisms. This drug affects many bacteria, both gram-positive and gram-negative.

Isofra is used in cases of damage to the upper respiratory tract by staphylococcus, Escherichia coli, Haemophilus influenzae, and Klebsiella.

Indications for use

Can be used in complex therapy of infectious pathologies of the nasopharynx, namely:

An antibiotic is used in the postoperative period to avoid inflammation, for example, with removed adenoids.

Contraindications

The use of drops and spray is contraindicated due to individual intolerance to antibiotics from the aminoglycoside group.

Use during pregnancy and lactation

Isofra during pregnancy can be prescribed by a doctor if there is potential benefit and the risk does not exceed the risk to the mother and fetus. The absorption of the antibiotic into the blood practically does not occur; therefore, the drug, as a rule, is not contraindicated in pregnant and lactating women.

Instructions for use

The instructions for use indicate that the spray is injected into each nostril after rinsing or cleansing the nose. The bottle should not be tilted while pressing the dispenser.

  • For adult patients, press the dispenser once four to six times a day.
  • For babies, press the dispenser once in each nostril three times a day.
  • Duration of use – up to ten days.

Drops should be administered into each nostril, one to two drops, four to six times a day into each nostril no more than once every two hours.

How to properly inject

To get the maximum effect of the spray, you must first apply vasoconstrictor drops or sprays such as Naphthyzin, Galazolin, Xymelin. When breathing becomes freer, try to clear the nasal passages by blowing your nose. Isofra spray is administered with the bottle in a strictly vertical position. The dispenser is first inserted into one nostril and one injection is made into the nose, then the same is repeated on the opposite side.

Do not make several injections at once. This artificially increases the dosage of the antibiotic and provokes side effects. The course of treatment with Isofra for sinusitis is no more than a week. If there is no improvement, the drug is discontinued and another one is prescribed.

Side effects

The relative rarity of side effects is explained by the local method of application of Isofra, in which its adsorption capacity, and, consequently, its effect does not extend to the entire body as a whole. In reviews of Isofra, which accumulated during post-marketing studies, only allergic reactions were noted as a side effect of the drug. Overdose with adequate use of the drug is practically excluded.

Overdose

Overdose with adequate use of the drug is practically excluded.

special instructions

With long-term use (more than 10 days), the possibility of disturbing the balance of the natural microflora of the nasopharynx should be taken into account. Should not be used to rinse the paranasal sinuses. It should be remembered that during treatment, resistant strains of microorganisms may appear.

Drug interactions

It was not detected in laboratory conditions. However, the drug may reduce the effectiveness of topical antifungals.

Reviews

We have selected some people's reviews about the drug Isofra:

  1. Anastasia . Can be taken from 6 months. My son was also prescribed it for yellow snot, the snot went away quickly. But be prepared for the fact that the next time you have a runny nose, no drops will help you other than isofra. Antibiotic kills everything! Now my son and I are suffering from snot, we only treat it with antibiotics! It’s a shame I didn’t listen to the pharmacist and recommended not to take the terrible drops.
  2. Elena . My son is 1.7 years old. I recently bought isofra because... The snot had been going on for 3 weeks already, it helped almost immediately, but on the 2nd day a terrible rash appeared all over my body and face, it stopped giving and everything went away. But the drug is very good, it cured my eldest son’s snot in 2 days, which lasted for a month.
  3. Alina. Isofroy always treats “complicated green” snot in myself and my children - when ordinary nasal drops are powerless, it helps. It’s just important not to get carried away, because Isofra still contains an antibiotic.

Analogs

There are drugs with similar effects, which allows you to choose a cheaper, but no less effective drug.

  • Polydexa. Unlike Isofra, it contains two antibiotics at once, which expands the spectrum of action of the drug. Each of the components acts on a specific group of pathogenic microorganisms, which makes it possible to achieve a more pronounced therapeutic effect. The product is available in the form of a nasal spray and ear drops.
  • Dioxidine. This antimicrobial agent is produced in the form of a solution, which is sometimes recommended to be dripped for a runny nose or otitis media. In some cases, the doctor prescribes complex drops with this component.
  • Grippferon. Nasal drops that have an antiseptic effect and quickly relieve inflammation. The active ingredient in the drug is recombinant human interferon. The cost per drop is rubles.
  • Framinazine. A cheap synonym for Isofra, costing from 30 to 60 rubles. The drug contains the antibiotic framinazine. Children under 6 years of age and pregnant women can take the medicine, but with caution and under the supervision of a doctor.
  • Rhinostop. A cheap analogue of Isofra, which also has antibacterial properties, relieves inflammation and can be used to treat infections in the respiratory system. The cost of the drug is from 35 rubles.

Before using analogues, consult your doctor.

Isofra or Polydex - which is more effective?

Sometimes an analogue of Isofra is considered to be Polydex nasal spray. The same manufacturer - the French Laboratory Bouchard-Recordati, similar packaging design. However, these drugs are not the same thing. If you use nasal antibiotics, then you need to know how Isofra and Polydexa differ.

Polydexa contains two antibiotics, not one. Accordingly, the range of its application is wider than that of single-component Isofra;

  1. Polydexa contains phenylephrine, an element with a vasoconstrictor effect;
  2. Polydexa contains the corticosteroid dexamethasone with anti-inflammatory and antihistamine effects;
  3. Polydexa, in addition to a nasal spray, is made in the form of ear drops and is successfully used in the treatment of otitis media.

Thus, Polydexa is a more powerful complex drug with antibacterial, anti-inflammatory, and vasoconstrictor effects. Therefore, it is impossible to say unequivocally what is better and more effective. But it is logical to start treatment with a simpler drug, i.e. from Isofra. If it is ineffective, switch to Polydexa with the doctor’s permission.

Storage conditions and shelf life

The shelf life of Isofra spray is 3 years from the date of its manufacture. The drug must be stored out of the reach of children at an air temperature no higher than +25° C.

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One comment

My son gets sick often, mostly with sinusitis and rhinitis. At the appointment, the pediatrician, seeing his green snot, prescribed Isofra and highly praised the drug. We bought it and tried it. It is easily tolerated and did not cause any adverse reactions. The only thing is that the child winces when I spray the medicine, apparently it tastes bitter. Improvement came quickly. I know that Polydex is also prescribed, but we have not encountered it yet.

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Source: http://simptomy-lechenie.net/izofra/

Nasal drops and Isofra spray for children - instructions for use, price

This article will discuss in detail the instructions for use of Isofra, as well as analogues of the drug. The antibacterial drug Isofra is used in ENT practice in the treatment of inflammatory processes in the nasopharynx, frontal and maxillary sinuses.

When our body is attacked by an infection, it is the upper respiratory tract that takes the first blow. Unpleasant sensations and discomfort can and should be removed using special means. Isofra is one of the most popular and effective medications for the treatment of various types of runny nose, and can be used by both adults and children.

Isofra - release form and composition

The drug is currently available only in the form of a nasal spray. Isofra drops are a non-existent drug that is not available on the pharmaceutical market. The release of this form of the drug containing an antibiotic is impractical due to dosage errors. Therefore, on pharmacy counters you can only find a spray in a 15 ml bottle.

The main active ingredient of the drug is framycetin sulfate. Its concentration is 12.5 mg per 1 ml of spray. The solution contains sodium chloride, citric acid, methyl parahydroxybenzoate and distilled water as excipients. In addition to the bottle of medicine, the cardboard package contains a spray nozzle and instructions for use. The shelf life of Isofra after opening the bottle is 1 month, before opening it is 1.5 years.

Mechanism of action and indications for use

Isofra nasal spray has a bactericidal effect and destroys a number of pathogenic microorganisms. The framycetin molecule is capable of inhibiting protein synthesis at the ribosome level, penetrating into the cell through the membrane. When applied topically, the drug has a detrimental effect on gram-positive and gram-negative bacteria, streptococci, staphylococci, facultative anaerobes and enterobacteria.

Isofra spray is prescribed as part of complex therapy for infectious and inflammatory processes in the upper respiratory tract:

The spray is also used as a prophylactic agent to prevent complications after surgery. Practice shows that Isofra spray effectively copes with nasal congestion in third-degree adenoids. It is worth noting that the drug is not used for infections of the nasopharynx by viruses and is not used in the treatment of ARVI or influenza.

Isofra spray for children

According to the instructions for use, this drug is approved for use in children over 1 year of age. However, some clinical studies have shown that the drug is safe and can be used for newborn babies. The effectiveness of the spray has been confirmed in the treatment of infants older than one month. At the same time, you need to remember that Isofra spray for children is prescribed only by your doctor. Self-administration of the drug in this case is unacceptable.

Despite the fairly comprehensive information contained in the instructions for the spray, the specific treatment regimen is determined by the pediatrician. At the same time, there are several basic nuances and rules that must be followed when treating runny nose in children using Isofra:

  • The duration of the course of treatment should not be more than 10 days. As a rule, already on the third day after using Isofra spray, positive dynamics are observed. If symptoms do not go away, you should inform your doctor. Most likely, you will have to change your treatment regimen.
  • One dose of the drug is injected into each nasal passage at a time. One click on the sprayer is enough for the drug to be completely distributed over the surface of the nasopharynx.
  • The frequency of use should not exceed 3 times a day.
  • Before using the drug, it is necessary to clean the baby’s nasal passages. To administer the medicine, simply apply the tip to the nostril. There is no need to inject it internally.

The use of such a spray guarantees maximum safety during the treatment process. The sprayed substance is better distributed over the affected mucosal surface and does not enter the baby’s stomach. The main component, framycetin, has low bioavailability and is practically not absorbed into the bloodstream. Thus, local use of the drug does not provoke nephro- and ototoxic complications.

Isofra spray for adults

The monocomponent drug Isofravnos is also used to treat adult patients with inflammatory processes in the sinuses and eustachian tubes. The daily dosage for this category of patients is from 4 to 6 injections per day in each nostril. To avoid the addition of fungal diseases and dysbiosis of the mucous membrane, the duration of the course of treatment should be no more than 10 days.

Is it possible for pregnant women to take Isofra? This is a pressing question that pregnant patients often ask their doctor. Despite the fact that the oto-nephro-vestibulotoxicity of the spray is extremely low, and the active substance of the drug hardly penetrates into the systemic circulation, its use during pregnancy is contraindicated. All drugs of the aminoglycoside type, entering the mother’s blood, negatively affect the developing fetus. Among the consequences of using the spray during pregnancy, one can note the possible development of bilateral deafness in the child.

During lactation, the use of this drug is also prohibited. The components of the spray can enter the baby's body through breast milk. The use of the drug is possible only after transferring the baby to artificial formula. You can resume breastfeeding only two weeks after completing the course of treatment.

Contraindications and side effects

This drug cannot be used if you are hypersensitive to framycetin. It is also not prescribed for hypersensitivity to aminoglycoside drugs. Due to little knowledge of the safety and effectiveness of the drug in pregnant and lactating women, it is contraindicated for this category of patients. Framycetin preparations should be used with extreme caution for patients with the following pathologies:

  • renal failure of any origin;
  • lesions of the vestibular apparatus;
  • acquired hearing loss of any degree;
  • taking anticholinergics, ganglion blockers, atropine and muscle relaxants.

Isofra spray is a fairly effective and safe product. Therefore, in the absence of kidney and inner ear diseases, the patient can safely use it within the recommended dosage.

The low systemic adsorption capacity of the drug virtually eliminates side effects. Patient reviews of the drug confirm the absence of such manifestations. With increased sensitivity to the components of the drug, allergic reactions may occur, which manifest themselves in the form of urticaria or a rash throughout the body, as well as signs of dysbacteriosis against the background of inhibition of the microflora of the nasal mucosa. Exceeding the recommended period of use may cause a fungal infection.

Average prices and analogues

The price of the drug in Russia varies from 250 to 400 rubles. However, there are drugs with similar effects, which allows you to choose a cheaper, but no less effective drug.

  1. Grippferon. Nasal drops that have an antiseptic effect and quickly relieve inflammation. The active ingredient in the drug is recombinant human interferon. The cost per drop is rubles.
  2. Miramistin. Used in the treatment of sinusitis, otitis and tonsillitis. It is a good alternative to Isofra. The price varies within rubles.
  3. Nesopin. The active ingredient is oxymetazoline, which copes well with sinusitis and otitis media. The price of the drug is 80 rubles.
  4. Rhinostop. A cheap analogue of Isofra, which also has antibacterial properties, relieves inflammation and can be used to treat infections in the respiratory system. The cost of the drug is from 35 rubles.
  5. Framinazine. A cheap synonym for Isofra, costing from 30 to 60 rubles. The drug contains the antibiotic framinazine. Children under 6 years of age and pregnant women can take the medicine, but with caution and under the supervision of a doctor.

Polydexa. Unlike Isofra, it contains two antibiotics at once, which expands the spectrum of action of the drug. Each of the components acts on a specific group of pathogenic microorganisms, which makes it possible to achieve a more pronounced therapeutic effect. The product is available in the form of a nasal spray and ear drops. Due to the high aggressiveness of Polydexa components, it can only be used for children over 2.5 years old. The average price is rubles.

It is worth noting that only a qualified doctor should determine analogues to replace Isofra. It is the specialist who can select the most suitable drug, taking into account the symptoms and general condition of the patient.

Reviews about the application

The youngest son suffered from a runny nose for more than two weeks. In the first week I thought that it would pass and there was nothing wrong with it, but when the symptom dragged on, I realized that something needed to be done. The green purulent discharge from the nose also frightened me. The swelling of the nasal mucosa did not go away, and my son could not breathe normally at night.

We tried various means: antispasmodic drops, sprays - nothing helped. At the doctor's appointment we were prescribed Isofra spray. I paid 250 rubles for a 15 ml bottle. According to the instructions, the spray was administered three times a day, one injection into each nostril. The very next day from the start of use, there was less nasal discharge and breathing through the nose became freer. By the third day, the discharge became clear, and on the fifth day the runny nose was completely gone.

Six months ago, the child developed a cold, or rather a runny nose. All other symptoms went away quite quickly, but there were problems with the nose. At first there was a clear discharge, and then it became thick, viscous and greenish in color. Nothing helped, and I had to go to the doctor.

That’s when we got acquainted with Isofra spray. I was confused by the fact that this is an antibiotic, and I am always cautious about the use of such drugs, especially when it concerns a child. But the pediatrician convinced me of the effectiveness and necessity of its use. The very next day after use, the child’s condition improved. Nasal discharge has become less abundant and clear. Three days later, this unpleasant symptom completely disappeared.

Review #3

I think that for almost everyone, even the mildest cold does not go away without a runny nose. But it can be different: sometimes it is quite easy to cure, and sometimes it goes into a protracted stage. Previously, I dealt with this symptom with various drops and sprays like Otrivin. But the last time, when the runny nose persisted and was accompanied by severe congestion and thick purulent discharge, I had to use other drugs.

The doctor advised using the topical antibiotic Isofra. I first heard about it, read the reviews, and decided to follow the specialist’s recommendations. Despite the fact that this is an antibacterial agent, it does not enter the bloodstream, but acts only on the surface of the nasopharynx. Before use, I washed my nose and injected one dose into each nostril 4 times every day. After three days, the runny nose was completely gone. The product is quite expensive - I bought it for 370 rubles, but one bottle is enough for several courses of treatment.

Ekaterina, Nizhny Novgorod

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Source: http://glavvrach.com/izofra/

Isofra spray - why is the drug considered unique in Russia?

Despite the prevalence of acute respiratory infections and associated pathology of the ENT organs among adults and children, many issues regarding their treatment still require clarification. The most difficult aspect is the rationale for prescribing systemic antibiotics in tablet forms. Recently, cases of their unjustified prescription have become more frequent, which often leads to various side effects and the development of pathogen resistance to treatment.

Considering the possible difficulties associated with systemic antibiotic therapy, the use of local agents with antibacterial activity has become relevant. The most convenient form for use has become nasal sprays, which, being absorbed into the blood in a minimal amount, can destroy pathogenic microorganisms that multiply in the nasal cavity and sinuses. These drugs include Isofra spray, created by the French laboratory Bouchara-Recordati.

>> The site presents an extensive selection of medications for the treatment of sinusitis and other nasal diseases. Enjoy it for your health! <

How does the spray against microorganisms work?

The main effect of Isofra is antibacterial. It has a bactericidal effect, that is, it can destroy bacterial cells. Its therapeutic effect is aimed at removing pathological discharge from the nose and sinuses. The prolonged existence of such a secretion without treatment contributes to the worsening of the disease, the flow of contents into the deeper layers of the respiratory tract and the occurrence of subsequent tracheitis and bronchitis. Isofra nasal spray can be called an etiological drug, that is, a drug that acts directly on the cause of the disease.

It is advisable to combine the use of Isofra with other measures for the treatment of sinusitis and rhinitis: rinsing the nose and sinuses with saline solutions, using vasoconstrictors, vitamin therapy, etc.

When can a spray be more effective than tablets?

Inflammatory diseases of the nose and paranasal sinuses can be caused by various microorganisms, including viruses and bacteria. In the upper respiratory tract, diseases can be caused by bacteria of various families, so effective therapy requires good antibiotics with a broad spectrum of action. One of these are aminoglycosides, which are active against most gram-positive and gram-negative bacteria. However, aminoglycosides in tablet forms have a fairly large number of side effects, the most dangerous of which is a toxic effect on hearing.

The possibility of using these drugs in the form of intranasal sprays has made it possible to safely use them for the treatment of infectious pathologies of the nasopharynx, sinuses and nasal cavity. A large number of clinical studies have proven that the absorption of local antibacterial drugs into the bloodstream is so small that it is unable to cause such serious complications. Thanks to this, in the treatment of many respiratory infections, the prescription of systemic antibacterial agents in tablet form can be avoided.

In some cases, even with the use of Isofra, the prescription of systemic antibiotics cannot be avoided. This spray can be combined with any other antibacterial therapy. The need for its use is evidenced by the prolonged persistence of symptoms during therapy, fever, chills, signs of intoxication, and deterioration in general health.

What is included in Isofra spray?

The main component of this drug is an antibiotic from the group of aminoglycosides, framycetin, intended exclusively for topical use in the nasal cavity. 1 milliliter of the drug contains 800 thousand international units of the main substance, which is several times lower than the maximum permissible dosage. Framycetin has a detrimental effect on the following types of bacteria:

It is these pathogens that in most cases cause infectious inflammation of the upper respiratory tract.

When can you not do without antibacterial spray?

Isofra is used for the treatment of infectious diseases that have developed in the upper respiratory region: the nasal cavity, nasopharynx, paranasal sinuses. Diseases with similar localization are the following conditions:

  • rhinopharyngitis;
  • rhinitis;
  • sinusitis (without concomitant damage to the septum).

Recently, otorhinolaryngologists began to prescribe Isofra for adenoiditis with a good therapeutic effect. It is also successfully used to prevent infections after surgical interventions in the nasal area. In response to surgical trauma, inflammatory reactions very often occur, which increase the likelihood of the addition of secondary pathogenic microorganisms. The use of topical antibacterial sprays to prevent the development of infection allows you to avoid the use of antibiotics, which can adversely affect the body weakened after surgery.

Isofra does not have a vasoconstrictor effect, that is, it does not eliminate swelling and congestion. To combat detailed symptoms, decongestant sprays (Tizin, Rinostop, Rinonorm, Naphthyzin, Nazol, Nazivin and others) should be used, but no more than 5 days in a row.

What rules should be followed during treatment with Isofra?

Isofra is prescribed to patients in the following doses:

  • children – one spray in each nasal passage 3 times a day;
  • adults – 1 spray in each nostril 4 to 6 times a day.
The duration of therapy with Isofra should not be more than one week. Prolonged and uncontrolled use can lead to the emergence of bacterial species that are resistant to standard therapy. In this regard, Isofra should be used only after a doctor’s prescription.

The bottle containing the drug is extremely easy to use. It does not require additional manipulations or special storage conditions. To spray effectively, you just need to hold the product vertically.

Some sources provide evidence that this antibacterial medicine can be used for inhalation. Is it possible to drip Isofra into a nebulizer? There is no information about this in the instructions, but sometimes ENT doctors can recommend this method of treatment. In such cases, it is necessary to strictly follow the recommendations of a specialist. The standard proportions for diluting the drug in a compressor inhaler are 3 drops of the drug per 2 milliliters of saline solution. The duration of the procedure is about 10 minutes. The duration of the course is determined by the doctor.

All contraindications and side effects are kept to a minimum

The undeniable advantage of Isofra is the absence of serious undesirable effects from its use and a large list of contraindications. Isofra should not be used only in the following cases:

  • during pregnancy and lactation;
  • for washing the paranasal sinuses and nasal cavity;
  • in the presence of hypersensitivity to framycetin or other components of the drug.

The only adverse reaction that rarely occurs after consumption may be an allergic process.

There are no known cases of overdose with Isofra. Experts are of the opinion that its occurrence is impossible as a result of low absorption into the blood.

At what age can Isofra be prescribed to children?

The instructions for using Isofra spray indicate that children can be treated with it, but there is no specific data on the age at which this therapy should be started. This indicates that this medicine does not have any age restrictions. This makes Isofra the only spray in Russia with antibacterial activity that can be used in children from the first days of life. The main condition for use at this age is strict adherence to the dosage and duration of therapy, which is indicated in the annotation. When treating children, you can resort to a shorter course (5 days).

ENT doctors are increasingly prescribing Isofra spray for children with adenoid growths. During clinical trials, it was proven that it significantly reduces the size of adenoid vegetations, which is associated with the correction of the bacterial flora in the nasopharynx under the influence of Isofra.

Can Isofra be prescribed during pregnancy?

The instructions for use of Isofra clearly state that it is contraindicated for use during pregnancy and breastfeeding. But rhinitis and sinusitis do not spare women who are waiting for the birth of their child. What to do in this case? Few women will agree to use a drug that lists pregnancy as a contraindication, even if this drug was prescribed by a doctor. There is a similar drug, the use of which is not contraindicated during pregnancy and lactation. We are talking about the antibacterial aerosol Bioparox, the main properties of which will be discussed below.

Drops and spray are not the same thing

Isofra on pharmacy counters exists only in the form of a spray. It is this form of release that contributes to the correct distribution of the drug in the nasal mucosa. Isofra nasal drops are a non-existent drug that is not represented on our pharmaceutical market. Any offers to purchase such a drug are fraudulent. Sometimes on forums you can find ways to use Isofra in the form of nasal drops for adults and children, but this information should not be trusted. Spray is the only form of release that guarantees the effective therapeutic effect of Isofra in the mucous membrane of the upper respiratory tract.

Isofra is not a panacea for acute respiratory infections

After reading the data on the effectiveness of this spray, many may have the erroneous assumption that it can be used for any rhinitis and rhinosinusitis. This is far from true. It must be taken into account that these diseases can be not only bacterial, but also viral in nature. Moreover, the onset of the disease is almost always associated with the penetration of a viral infection into the area of ​​the nasal mucosa, which is subsequently contaminated with bacterial flora. Using Isofra for viral infections will not bring any benefit, but can only cause harm. How to determine the cause of the disease?

With viral rhinitis and sinusitis, nasal discharge is clear or whitish. The spread of bacterial flora will be indicated by a change in its color to green or yellow. In such cases, we can already talk about a runny nose of a purulent nature, which requires the prescription of antibacterial agents. For parents, the criterion for the need to use Isofra spray may be the persistence of symptoms of the disease for more than 7 or 10 days, as well as the appearance of “green snot” that occurs with sinusitis. Even after these signs appear, you should not resort to treatment with Isofra on your own, because each specific case of the disease requires an individual approach, which can only be provided by the attending physician.

Polydexa is a good replacement option, but care must be taken

Isofra has no analogues identical in composition to the original medicine. This makes it urgent to search for drugs that can replace it if necessary. The drug Polydex, like Isofra, is produced by the pharmaceutical company Bouchard-Recordati Laboratory. Both drugs have almost identical indications for use, but have certain differences that allow them to be used to solve slightly different problems.

vasoconstrictor (removing congestion);

The choice of a specific drug depends on the clinical situation, the patient's age, symptoms and concomitant diseases. For severe complaints of congestion and severe swelling, the use of Polydexa may be preferable because it is a three-component remedy and can reduce the number of sprays used to treat an episode of the disease. This is very important for young children who may refuse to use several sprays at once.

Isofra or Polydexa: which is better for children? There is no clear answer. Of course, Isofra should be used to treat children under 2.5 years of age, because Polydexa is prohibited at such an early age. The choice of drug for the treatment of older children depends on the specific clinical case, so only a specialist should prescribe drugs.

Bioparox or Isofra?

In addition to Polydexa, there are other worthy drugs on the Russian pharmaceutical market that are similar in their effect to Isofra spray. One of these medicines is Bioparox aerosol. It is based on a polypeptide antibiotic that is active against the following pathogens:

  • some anaerobic species of bacteria;
  • streptococci;
  • staphylococci;
  • yeast-like fungi;
  • mycoplasma

Bioparox has a slightly different spectrum of sensitivity, as well as a wider list of indications. It can be used not only for the treatment of infectious diseases of the nose, pharynx (rhinitis, nasopharyngitis) and sinuses (sinusitis), but also for laryngitis, tracheitis, tonsillitis and bronchitis. This is ensured by the possibility of its use not only in the nose, but also in the oral cavity.

It cannot be said unequivocally that one drug is better than another, because they are effective against different pathogens and pathologies. It is ideal to prescribe an antibacterial spray after identifying the pathogen on the mucous membrane of the nose or pharynx, but this is not always done, and besides, the culture is prepared within two or even three weeks. The ineffectiveness of one remedy should lead to the idea that its antibacterial component may not have an effect on the pathogen that caused the pathology. In such cases, the drug must be replaced with another.

Source: http://gaimoriti.ru/medicamenty/izofra.html

Isofra

Description current as of 04/09/2014

  • Latin name: Framycetin
  • ATX code: R01AX08
  • Active ingredient: Framycetin sulfate
  • Manufacturer: Sofartex for the Bouchard-Recordati Laboratory, France

Compound

One ml of the medicine contains framycitin 12.5 mg + excipients (E 218, sodium chloride, citric acid, H2O).

Release form

Spray - 15 ml, in bottles.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

When an antibiotic comes into contact with the nasal mucosa, it undergoes a rapid process of systemic absorption, so the pharmacokinetics of the drug have not been studied. Acts as an antimicrobial agent, active against gram-positive and gram-negative bacteria.

Indications for use

Isofra nasal spray with framycetin is prescribed for complex treatment:

Contraindications

Children under one year of age. Individual intolerance to the antibiotic in the composition and other components of the drug.

Side effects

In general, the drug is always well tolerated. But there have been cases of allergies.

Instructions for use of Isofra (Method and dosage)

Intranasally. When first used, you should release a couple of doses of the medicine into the air. Hold the nasal spray vertically and lean your head slightly forward.

Adults are prescribed one spray into each nostril 4 to 6 times a day.

Instructions for use by children: One injection 3 times a day.

The drug should not be used for more than a week.

Unlike nasal drops, the spray is much more convenient to use, eliminates the possibility of the drug flowing down the back wall of the nasopharynx, and is precisely dosed. Drops can also simply flow out of the nose.

The instructions for Isofra are provided for informational purposes only; the dosage and duration of use during treatment should be prescribed by a doctor.

Overdose

No cases of overdose have been reported.

Interaction

It was not detected in laboratory conditions. However, the drug may reduce the effectiveness of topical antifungals.

Terms of sale

Not available freely, requires a prescription.

Storage conditions

In a dark, cool place, protected from children, the temperature should not exceed 25 degrees.

Best before date

Shelf life: 18 months. Shelf life after opening is 1 month.

Analogues of Isofra

At this time, there are no drugs with the same active antibiotic. There are similar drugs containing aminoglycosides: amikacin, bramitob, garamicin, dilaterol, streptomycin and others.

Also analogues are: Aqua Maris, Aquazolin, Boromenthol, Polydexa, Bioparox and others. The price of analogues is often lower than the original.

What is better Isofra or Polydex?

Polydexa is not a complete analogue of the drug. It contains two types of antibiotic, hormones and phenylephrine. The last of the components, among other things, has the property of constricting blood vessels. And hormones make it possible to use the drug for allergies. In this regard, the use of Polydex for children is justified. But do not forget that only a doctor can choose the drug you need.

Which is better Isofra or Bioparox?

Bioparox has a wider range of microbes on which it has a detrimental effect. Also, thanks to the inhalation technique, the drug penetrates deeper into the nasal sinuses and cavities. The disadvantage of the drug is the fact that it is contraindicated in children under 3 years of age and often becomes ineffective with long-term use due to addiction.

For children

There are age restrictions for using the drug for children.

At what age can Isofra be used? From one year.

During pregnancy and lactation

Isofra during pregnancy can be prescribed by a doctor if there is potential benefit and the risk does not exceed the risk to the mother and fetus. The absorption of the antibiotic into the blood practically does not occur; therefore, the drug, as a rule, is not contraindicated in pregnant and lactating women.

Reviews for Isofra

Reviews for nasal drops are mostly good. They write that the drug helps well in the early stages of the disease and if the causative agent is bacteria. For viral diseases, such nasal drops are ineffective. Many managed to cure a runny nose in a couple of days, but then had problems restoring the microflora of the nasopharynx.

Reviews for sinusitis: Nasal drops with antibiotics do an excellent job of treating this disease. Improvements occur already on the third day, but if this does not happen, it is advised to stop treatment with the drug. There are cases when it was possible to cure a chronic disease with their help. Doctors themselves often prescribe Isofra for sinusitis.

Reviews about taking Isofra by children: Many people are interested in what age children can take the drug and whether it can be used for a child under one year old. The correct answer is no.

The instructions for Isofra for children say that a doctor should prescribe the medicine. It is he who can draw a conclusion about the nature of the disease. Many parents try to self-medicate and do not get the expected effect. Those who took it after its appointment considered it a panacea for rhinitis, sinusitis and sinusitis. The product has good performance and reviews for adenoids.

The price of Isofra for children is quite reasonable, especially since the medicine has a short course.

Isofra price (where to buy)

How much does Isofra cost in Moscow? In the capital, the price of a nasal spray is about 186 rubles. The cost of the drug in Russia is on average 170 rubles per 15 ml.

The price of nasal drops in Kyiv pharmacies is from 72 to 138 hryvnia. On average - 93 hryvnia.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Ukraine Ukraine

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Great spray. It was prescribed by an ENT specialist for adenodes. 3 times a day, 1 spray. We are 2 years old. After the first day of treatment, the child did not snore at night and did not wake up. I breathed through my nose.

Good drug! At the pharmacy, the pharmacist recommended Isofra, I bought it for my daughter. if snot starts, we start spraying 1 spray into each nasal passage 3 times a day, after 2 days the snot seems to have never happened.

His term of oneness is clearly not 18 months, but more, perhaps. I have Isofra, it says until September 2017, but now it’s September 15, I don’t remember when I bought it, and the release date is not indicated

Konstantin: What I liked about the drug Prostanorm: reasonable price, pronounced effect of taking it.

Valentina: I, too, am all about diet and exercise. I hoped for loads, I thought that my healthy lifestyle.

Nina: I was on pills for a year and a half, then somehow everything calmed down. Mostly climatefit.

Elena: With the onset of menopause, the skin completely deteriorated and became dry. I saw a cream for .

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/izofra

Isofra: instructions for use

Isofra spray is an antibacterial agent for external local use. It is used to treat infectious and inflammatory processes localized in the ENT organs caused by bacteria sensitive to the drug.

Release form and composition

The main active ingredient of Isofra spray is framycetin sulfate. Its content in 1 ml of spray is 12.5 mg (8000 IU - international units). Auxiliary components of the drug are:

  • Sodium chloride.
  • Methyl parahydroxybenzoate.
  • Lemon acid.
  • Distilled water.

Isofra spray is in a 15 ml polyethylene bottle. A cardboard pack contains one bottle, a spray cap and instructions for use of the drug.

pharmachologic effect

The main active ingredient of Isofra spray is an antibiotic of the aminoglycoside group. It has a bactericidal effect (leads to the death of bacterial cells) against a large number of different pathogenic microorganisms, including gram-positive and gram-negative bacteria that cause inflammatory pathology of the ENT organs. The bactericidal effect is realized due to damage to the cytoplasmic membrane of the bacterial cell and disruption of intracellular protein synthesis.

When used externally, the active substance of Isofra spray is not absorbed into the systemic circulation.

Indications for use

The use of Isofra spray is indicated for etiotropic therapy (treatment aimed at destroying the causative agent of the infectious process) of bacterial diseases of the ENT organs, in particular rhinitis (inflammation of the nasal mucosa), pharyngitis (inflammation of the pharynx), sinusitis (inflammation of the paranasal sinuses).

Contraindications for use

An absolute contraindication to the use of Isofra spray is individual intolerance to the active substance or auxiliary components of the drug.

Directions for use and doses

Isofra spray is used intranasally. They irrigate the nasal mucosa, and the bottle must be kept in an upright position. The average dose for adults is 4-6 irrigations per day. The course of treatment should not exceed 10 days.

Dosage and use of Isofra spray for children

Children receive one spray into each nostril 3 times a day.

The duration of treatment for children is no more than a week.

At what age can Isofra be used for children?

Isofra spray is not recommended for use in children under 1 year of age. However, exceptions are possible, and the drug can be prescribed by a doctor for a child from 1 month old.

Side effects

In general, Isofra spray is well tolerated. Sometimes during its use it is possible to develop local negative reactions in the form of allergic skin reactions (skin rash and itching).

special instructions

Before you start using Isofra spray, you must carefully read the instructions for the drug. There are several special instructions, which include:

  • Use of the drug for more than 10 days can lead to disruption of the normal microflora of the nasal mucosa and the development of dysbacteriosis.
  • Lack of improvement after starting to use the spray for 10 days is the basis for treatment correction.
  • The drug does not affect the speed of psychomotor reactions and the ability to concentrate.

In the pharmacy chain, Isofra spray is available without a prescription. If you have any questions or doubts regarding its use, you should consult your doctor.

Overdose

There is currently no data on significantly exceeding the recommended therapeutic dose of Isofra spray.

Terms and conditions of storage

The shelf life of Isofra spray is 3 years from the date of its manufacture. The drug must be stored out of the reach of children at an air temperature no higher than +25° C.

Isofra analogues

Isofra is an antibiotic from the aminoglycoside group. In terms of the active substance - framycetin - Isofra spray has no analogues. But there are similar drugs of the same pharmacological group.

Framinazine is the most popular analogue of Isofra. The drug belongs to the same pharmacological group of antibiotics as Isofra, and is just as effective in treating infectious and inflammatory diseases. Framinazine is often used as a prophylaxis for inflammatory processes after surgery. Both sprays are not recommended for use for more than 10 days.

Polydexa is a multicomponent spray that has not only anti-inflammatory and antibacterial effects, but also vasoconstrictor. Although the compositions of Polydex and Isofra are completely different, the clinical actions are similar. Adverse reactions after taking Polydex are rare, but there are many contraindications.

Bioparox is effective not only in the treatment of infectious diseases of the nose, but also in the treatment of bronchitis, laryngitis and tonsillitis. The antibiotic contained in its composition copes well with pathogenic bacteria. Bioparox is often used after the course of taking Isofra has ended. In some cases, Bioparox turns out to be even more effective.

Rinofluimucil is an anti-inflammatory, vasoconstrictor and decongestant drug - a good analogue of Isofra. Effectively thins mucus in the nose and copes well with even severe forms of sinusitis and rhinitis. Rinofluimucil has some contraindications; it should not be given to children under 3 years of age, nor should it be used for a long time, as addiction is possible.

Vibrocil is a drug with a pronounced anti-inflammatory, vasoconstrictor and antiallergic effect. Vibrocil copes well with various forms of rhinitis and sinusitis. This analogue of Isofra cannot be used for longer than 2 weeks, since prolonged vasoconstrictive effects can cause a medical runny nose. In addition, the dosage must be strictly observed.

Among non-aerosol preparations, inexpensive Protargol drops should be noted. Despite the fact that Protargol has a completely different composition than Isofra, in terms of its action these are the two most identical drugs. Protorgol contains three more active substances that are absent in Isofra, so Protargol has a more versatile effect on the body.

Isofra spray price

The average cost of Isofra spray in Moscow pharmacies is rubles.

Source: http://bezboleznej.ru/izofra

Isofra - instructions for use for children and adults + analogues + recipe in Latin + reviews

French drops (spray) in the nose Isofra is one of the most popular remedies for the treatment of a runny nose. It also effectively helps with sinusitis and rhinopharyngitis of bacterial origin, relieving characteristic symptoms already on the third day of use. Pediatricians especially often prescribe the drug, since the spray is safe and approved for use in children starting from the second year of life. The medicine has a minimum of contraindications and does not have systemic side effects on the body.

Isofra - instructions for use for children and adults

Positive reviews of the drug from adult patients and parents of babies to whom the spray was prescribed by a pediatrician indicate its undoubted effectiveness. Painful symptoms pass quite quickly, nasal congestion disappears, and complete recovery occurs in record time. In this regard, a logical question often arises: Is Isofra an antibiotic or not, and does it harm the body, like most antimicrobial drugs?

Yes, Isofra is an aminoglycoside antibiotic, a derivative of one of the first generation representatives of this group (neomycin). It is intended exclusively for local use in otolaryngological practice, and in combinations it is also used in ophthalmology and proctology. Therefore, treatment with this nasal spray, especially for children, requires a responsible approach and prior consultation with a doctor.

Pharmacological group

It belongs to aminoglycosides, since the active substance of the drug framycetin is a structural component of the first generation antibiotic of this group. ABP is intended only for local use in otolaryngology.

Composition of Isofra

The active ingredient of the nasal spray is the bactericidal agent framycetin, a derivative of the aminoglycoside antibiotic neomycin. It has a detrimental effect on pathogens due to damage to the cell membrane and disruption of metabolic processes inside the cell. The following pathogens exhibit sensitivity to the drug:

  • some gram-positive species of streptococci and penicillin-resistant staphylococci;
  • gram-negative pathogens of ENT infections - Klebsiella, Shigella, Pseudomonas aeruginosa, Salmonella and Proteus spp.

Anaerobes, certain strains of streptococci and treponema are immune to framycetin. In general, resistance to this antibiotic in pathogens develops quite slowly.

Release form

The medicine Isofra for the runny nose and some other infections of the ENT organs is available in the form of a spray. The manufacturer, the French pharmaceutical company Laboratoires Bouchara-Recordati, offers the medicine in 15 ml plastic bottles with a spray dispenser, additionally packaged in cardboard boxes.

Isofra nasal spray

The drug contains the active ingredient framycetin in an amount of 12.5 mg per milliliter, as well as auxiliary components: distilled water, citric acid, sodium chloride and citrate, methylparaben. The average cost of one package in pharmacies is 300 rubles.

Since most remedies for the common cold have the property of constricting blood vessels, thus reducing mucus production and preventing congestion, the question often arises:

As can be seen from the ingredient composition, there are no vasoconstrictors (compounds such as naphthysine that affect vascular tone) in the drug. Therefore, it does not have a vasoconstrictor effect, but is intended to combat exclusively the cause of the disease - infection.

Recipe in Latin

If Isofra spray is indicated for sinusitis, rhinitis or other ENT infections, the medical prescription must be properly documented on a special prescription form. Without this document, pharmacists and pharmacists from the beginning of 2017 do not have the right to dispense medicines according to the new rules. The prescription must contain some information about the patient, and also be certified by the seal and signature of a specialist.

Rp.:Spray"Isofra" 15 ml

DS One injection into each nasal passage three times a day.

Indications for use Isofra

Colds, usually of a viral nature, are often complicated by the addition of a bacterial infection. Such situations are especially typical for children, whose anatomy of the respiratory system facilitates infection by pathogenic microorganisms. Pediatricians prescribe a French-made spray for purulent green snot, the cause of which is:

  • acute runny nose of bacterial origin (nasopharyngitis);
  • chronic rhinitis;
  • inflammation of the paranasal sinuses (sinusitis), if there is no curvature of the nasal septum.
The nasal remedy Isofra for sinusitis, acute or chronic runny nose is widely used in adults. There is no special, more concentrated form of release; the medicine is simply sprayed into the nose more often than in the case of treating small patients.

Contraindications

Like any drug, this medication is strictly contraindicated in case of individual intolerance to its components: framycetin or aminoglycosides in general, auxiliary ingredients. It is also not recommended to use Isofra nasal spray during pregnancy from the 1st to 3rd trimester (that is, at any stage) and during breastfeeding.

Dosage

The medicine acts locally, on the surface of the mucous membranes of the respiratory organs, without penetrating into the bloodstream and, accordingly, without having a systemic effect. That is why this antibiotic can be used in pediatrics without fear of harmful effects on the child’s body. For the same reason, there have been no cases of overdose, as well as interactions with drugs taken orally or parenterally.

For children

Isofra is usually prescribed to a child with thick green snot, the appearance of which indicates the addition of a bacterial infection. In this case, before each use, it is recommended to first rinse the stuffy nose with special ready-made saline solutions sold in pharmacies or with regular saline solution. This procedure helps cleanse the mucous membranes and enhances the therapeutic effect of antibiotic therapy.

Holding the spray bottle strictly vertically, you need to perform one injection into each of the nasal passages. This is done three times a day (no more often) for several days, but no more than a week. Usually, the symptoms of the disease weaken or disappear completely on the third day of treatment, but if after 7 days the disease does not go away, you should stop using the drug and consult a doctor about changing the drug.

For adults

General recommendations for use are almost the same as for children. It is also advisable to rinse the nasal passages before administering the medicine, then make one injection into each of them. The maximum duration of a course of antibiotic therapy is 7 days. The only difference is the frequency of application: adult patients need to do this from 4 to 6 times a day.

Side effects of Isofra

When applied topically, the active substance does not enter the bloodstream, therefore it does not have a systemic effect on the body and does not cause dyspeptic disorders, dysbacteriosis, disorders of nervous activity and other negative reactions characteristic of antibiotic therapy. The side effect of this nasal spray can manifest itself (in very rare cases) only in the form of a local allergy - burning or redness.

Isofra during pregnancy and breastfeeding

There is no reliable data on the effect of framycetin on the fetus and the degree of penetration into breast milk, since large-scale clinical studies have not been conducted. If we take into account the inability of the antibiotic to penetrate the blood, we can conclude that it is safe, however, the manufacturer in the instructions for use prohibits prescribing the drug to pregnant women at any stage and lactating women.

Isofra and alcoholic drinks

Antimicrobial drugs for topical use do not mix with ethanol entering the blood. From this one can draw an erroneous conclusion about the compatibility of nasal spray and alcohol. However, alcoholic drinks dilate blood vessels, causing a rush of blood to the tissues, as a result of which the formation of mucus increases, swelling increases, and the condition generally worsens. In addition, alcohol in any case has a negative effect on the body weakened by the disease.

Isofra - analogues are cheaper

The cost of the medicine from the French manufacturer is quite high (at least 300 rubles for one bottle), but the packaging is enough for the full course of treatment. If, however, there is a need to replace the medication, you need to consult a doctor, since there are no structural analogues of the framycetin-based spray. Usually in this case, antiseptics suitable for the treatment of adults and children are recommended:

  • Protargol is a 2% solution that is prepared in a pharmacy and costs about 100 rubles. True, pharmacists often offer a ready-made analogue called Siarol, which is not inferior in price to Isofra.
  • Oil solution Chlorophyllipt, which helps to cope with a runny nose in combination with systemic medications - 20 ml costs approximately 140 rubles.
  • Miramistin is an antiseptic spray, 50 ml of which will cost 200 rubles.
  • Collargol is an antiseptic drug with bactericidal action, which is prepared directly in the pharmacy. Its price can range from 100 to 150 rubles.
  • Okomistin is an eye drop that is also used in otolaryngology. The cost of a 10 ml dropper bottle starts from 130 rubles.

There are also more expensive medications that effectively cope with ENT infections. For example, people often ask which is better - Rinofluimucil or Isofra, the cost of which is approximately the same. Firstly, it should be borne in mind that Rinofluimucil, unlike the French medicine, is not an antibiotic, but has an anti-edema, vasoconstrictor and anti-inflammatory effect. That is, it fights the symptoms, not the cause, although it is considered effective.

Secondly, it has more contraindications and is also capable of causing a greater number of adverse reactions, including those associated with heart rhythm disturbances. And thirdly, the drug is not recommended for use in children under two years of age. Therefore, the most popular medications for the common cold should be considered in more detail in comparison with Isofra.

Isofra or Polydexa - which is better for children

Both drugs are produced in the form of a nasal spray by the French company Bouchard and contain an antibiotic that acts locally, and are also prescribed for similar diseases and sold at a similar price. What makes Isofra and Polydex different is their quantitative and qualitative composition, which determines the list of contraindications.

Polydexa combines two antimicrobial compounds – neomycin and polymyxin, which significantly expands the spectrum of bactericidal activity. Dexamethasone and phenylephrine, in addition, provide a vasoconstrictor effect and relieve inflammation. In general, this medication is more effective, but it should not be prescribed to people with kidney failure, or to children under 2 and a half years of age.

Isofra or Derinat?

Children from the first days of life can be prescribed the immunostimulating drug Derinat for the treatment of ENT infections.

Sodium deoxyribonucleate, the active ingredient in the spray, is effective as part of a complex treatment and does not have a direct effect on pathogens, only strengthening the body’s defenses. Therefore, the question of the advisability of replacing this medicine can only be decided by a pediatrician or otolaryngologist.

Isofra - reviews for children

Both doctors and parents confirm the effectiveness of the French spray for runny nose and sinusitis. It quickly copes with the cause of the disease – pathogenic microflora – and alleviates the child’s condition within 2-3 days of use. By the end of the recommended course, the disease usually goes away completely without causing complications or side effects.

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