Paracetamol how to take

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How to take Paracetamol

Paracetamol is in first place on the list of the international health organization among the most popular and vital drugs. This provision is due to its safety and effectiveness.

Table of contents:

In this regard, the question of how to take Paracetamol is heard quite often, since the medicine is freely available in all pharmacy chains in the world.

There are a wide variety of forms of release of this drug, for example, the following:

  • rectal suppositories;

When should you take Paracetamol?

The drug has a pronounced antipyretic, moderate analgesic and weak anti-inflammatory effect. This characteristic indicates that it can be used in the following situations:

  • hyperthermia with influenza, ARVI;

If you experience any painful sensations or sudden fever, you need to contact a highly qualified doctor to determine the cause and prescribe an effective treatment plan.

Uncontrolled, self-administration of Paracetamol can aggravate the situation and blur the clinical manifestations of a serious pathology, which will complicate the diagnosis and differentiation of the diagnosis.

Paracetamol dosage

Only a doctor can determine exactly how to take the medicine and in what dose. Typically, the dose for a child is mg per 1 kilogram of weight, and for adults, tablets and capsules with a dosage of 325 and 400 mg are recommended.

In children, age and weight must be taken into account, which is detailed in the annotation for the drug. The frequency of administration is no more than 4-5 times a day at the rate of every 3.5-4 hours for severe hyperthermia caused by respiratory viral diseases or teething.

In adults and children over 14 years of age, the situation is a little simpler, since the main caveat is the daily dose of the drug, which should not exceed 4 grams, with the possible use of a single dosage of up to 1 gram. To safely use an antipyretic drug, you must strictly follow your doctor's recommendations.

Features of the use of paracetamol

Paracetamol and other antipyretic drugs should always be taken with plenty of liquid. This way the antipyretic effect will come faster and be more pronounced. The state of hyperthermia, in principle, requires compliance with an increased drinking regime, since there is a large release of toxins into the bloodstream, and additional liquid helps to wash them out as quickly as possible.

The required volume of liquid is approximately 2-3 liters for an adult and 1.5 liters for a child over 2 years old. Experts recommend drinking tea with honey, raspberry jam and lemon, as well as decoctions of linden, chamomile and sage. To neutralize increased acidity caused by frequent use of antipyretics, you should drink warm milk with a pinch of soda.

Precautionary measures

The instructions for the package contain a description of how to drink Paracetamol correctly, which almost everyone reads. But few people study precautionary measures, because they are convinced that the drug is absolutely safe. In fact, Paracetamol has a number of side effects that occur rarely and in cases of overdose. If you take the drug thoughtlessly, the following situations may occur:

  • renal and liver failure;

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All about Paracetamol - description of the drug.

Today, the most popular antipyretic drug is still Paracetamol. For many decades, it has been at the forefront of most medications prescribed for colds and acute respiratory viral infections. In Russia, for example, almost 200 such drugs are registered, designed to alleviate the condition of fever, influenza, acute respiratory infections and acute respiratory viral infections. All of them are sold under different trade names, but their composition, principle of action, indications and contraindications are almost identical.

Before you continue reading: If you are looking for an effective method of getting rid of a runny nose, pharyngitis, tonsillitis, bronchitis or colds, then be sure to look at this section of the site after reading this article. This information has helped so many people, we hope it will help you too! So, now back to the article.

Paracetamol-containing drugs differ only in the dose of the active substance and auxiliary components. So Paracetamol can be bought in the following dosage: 10 mg, 200 mg, 500 mg, 325 mg. Which of the listed doses should you choose and how to take the drug?

Until 1990, a single dose of Paracetamol was equal to 0.5 g, now it is equal to 1 g. Accordingly, the daily dose was equal to 1.5 g, now it is legal 4 grams. What is the reason for this increase, and which of them should you follow?

The main answer is that the previous doses no longer work on modern humans. This is stated by practicing therapists and foreign sources of information. In the USA, several years ago, the daily dose of the drug was officially reduced by 1 gram and is now 3 grams per day for an adult. A large number of pediatricians generally do not recommend giving this medicine to children under 6 years of age, although the instructions for use of Paracetamol (Fervex, Panadol) still say that this drug can be used to reduce fever and pain in children from 1-3 months life.

Feeling the symptoms of an impending cold or flu, a person tries to quickly “drown out” them by taking a large number of medications, sometimes identical in composition, with the only difference being the name. Such thoughtless self-medication can lead to complex diseases as a result of an overdose of Paracetamol. Overdose occurs not only when the dose of tablets, syrups, etc. is exceeded, but also with concomitant intake of coffee, black tea, alcohol (in large quantities), loss of appetite and other nuances. More on this a little later.

What kind of medicine is Paracetamol and how to take it?

The drug in question belongs to the antipyretic, analgesic and anti-inflammatory drugs of weak action. It is available without a doctor's prescription, as it is considered relatively safe, but quite effective. The main active ingredient is paracetamol as a synthetic compound. The use of Paracetamol is indicated for fever caused by high temperature during colds, flu, acute respiratory viral infections and acute respiratory infections. For dental, headache, muscle pain, neuralgia, myalgia, arthralgia.

The action of Paracetamol comes down to its effect on brain cells, which give a signal to the thermal center to reduce excitability. As a result, regulation and normalization of heat generation and heat transfer and a decrease in body temperature occur.

In medicine, paracetamol-containing drugs can be classified as “experimental” drugs. Doctors say that if Paracetamol brings down a high temperature quickly and for a long time, it means that we are talking about a common cold, and there is no reason to worry, but if the situation is different, and the temperature decreases by only a degree or less, then it is impossible to do without a specialist’s diagnosis. Most likely, there is an infection “working” in the body, which needs to be eliminated the faster the better. Remantadine, Anaferon, Arbidol and other antiviral drugs will help to cope with the infection more easily. They are prescribed both during illness and for prevention before a predicted epidemic of ARVI. These medications are used quite successfully in pediatric and adult therapy.

How to take Paracetamol?

According to the instructions for Paracetamol, it can be prescribed to children of the first year of life from 3 months. It is advisable for all categories of the population to take the drug an hour or two after meals, so as not to delay its antipyretic and analgesic effect. Drink plenty of water.

The dosage of Paracetamol is as follows: adults and adolescents over 12 years of age should take 500 mg or 325 mg of the drug no more than 4 times a day. Children from 6 to 12 years old are prescribed 200 mg or 300 mg 3-4 times a day, and children from 3 to 6 years old are prescribed 3-4 times a day. For children under 3 years of age, it is better to take the product in the form of suppositories, syrup or suspension. Paracetamol can be taken 3-4 times a day. This does not mean that you need to strictly follow this scheme. If there is a temperature, an appointment is needed, if not, it is not needed.

Paracetamol is not an antibiotic, not a vitamin, etc. is a symptomatic drug designed to alleviate the negative manifestations of the disease, and not to treat the disease itself.

Contraindications and overdose

Contraindications when taking the drug: kidney and liver diseases, frequent consumption of alcoholic beverages, individual sensitivity. It should be taken with caution during pregnancy and breastfeeding.

The harm of Paracetamol is relative. If the patient does not “suffer” from the conditions described above and uses the medicine within acceptable limits, maintaining the time interval, side effects will not take him by surprise. Otherwise, most likely, one should expect such body reactions as allergies, nausea, vomiting, abdominal pain, increased excitability or drowsiness, decreased hemoglobin levels, and renal colic. An allergy to Paracetamol can manifest as itching, skin rashes, and tissue swelling. Reading reviews of the drug, it is clear that an allergic reaction is most often observed in children in the first year of life.

Paracetamol and liver are especially in conflict. This is the main side effect. The drug is quickly absorbed and spreads through the blood vessels throughout the body, reaching the peak of its effect in minutes. The main breakdown of the substance occurs in the liver. It is here that it turns into metabolic products that are harmful to the liver itself. These metabolites can destroy liver cells. Exceeding the dosage leads to this. The consequence of this treatment is that the liver stops functioning, and the patient can only be saved by a transplant of this organ. If a person has liver problems, Paracetamol is contraindicated for him. In the case of alcoholism, the harm of the drug increases several times. Their combined action increases each other's toxicity to the kidneys and liver tenfold. Not every body can withstand such a load.

By the way, the effect of Paracetamol, harm and overdose began to be studied more carefully after an increase in deaths from its use. Young people suffered, usually inadvertently using large doses of Paracetamol or combining several products containing this substance at the same time, without calculating its total amount.

But it’s not for nothing that every instruction for the use of Paracetamol and other medicines says that before using the drug you should carefully study this insert and save it for future use. In addition, valid indications (reasons) for taking the medicine were also not always present.

Interaction with other drugs

The most popular interaction of substances is paracetamol and caffeine. This compound has a double effect on the body. Paracetamol brings down the temperature, and caffeine increases this function by increasing the concentration of the former in brain cells. As a result, the antipyretic effect increases significantly, plus the body receives a boost of energy and vigor under the influence of caffeine.

Caffeine and paracetamol are often used for low blood pressure headaches. In this case, an analgesic and vasodilating effect is ensured. They are also the main active ingredients in Panadol extra tablets.

The next interaction is Paracetamol and No-shpa. They fight well against severe headaches and high fever, especially in young children. No-spa relieves vasospasm, and Paracetamol performs its main antipyretic function.

Next is the interaction of Paracetamol and Analgin. In some cases, Analgin reduces fever better than paracetamol-containing medicine or Aspirin. This applies to intramuscular injection of analgin with diphenhydramine, when the effect occurs within 15 minutes. Regarding Analgin and Paracetamol, they cannot be combined with other anti-inflammatory drugs.

Paracetamol and Aspirin have similar mechanisms of action, only Aspirin also thins the blood. Paracetamol is safer than Aspirin, which has many contraindications and causes stomach irritation in almost everyone. There is no point in taking these antipyretic and painkillers at the same time, and the load on the kidneys and liver is high. They can only be alternated at high temperatures to prevent overdose.

Ibufen and Paracetamol are different drugs in composition, but belong to the group of antipyretic and analgesic drugs. Ibufen also has a strong anti-inflammatory effect, so it is considered a drug with a wider spectrum of action. As a rule, Paracetamol is often replaced with Ibufen, since the latter in most cases copes better with high fever. These medications are not prescribed together.

Nurofen and Paracetamol are often prescribed for high fevers that are not brought down by any drug alone. The main thing is to maintain a time interval between doses. Nurofen usually works more effectively and lasts longer. Nurofen is preferable to Paracetamol due to its lower “harmfulness” and allergenicity.

Suprastin and Paracetamol are a typical fever-relieving compound for people with a possible allergic reaction. Most often, Paracetamol and Suprastin are recommended by pediatricians during the post-vaccination period when body temperature rises, the first drug as an antipyretic, and the second as an antihistamine. If during the period of illness the doctor prescribes a lot of other drugs, then it is advisable to take Suprastin to reduce the risk of allergies.

The price for domestically produced Paracetamol can be several times less than for foreign analogues with big names. So 10 tablets of 500 mg each cost about 3 rubles.

The price of Paracetamol for adults is about 50 rubles, and for children – about 90 rubles. The cost of an imported drug averages from 30 rubles for 10 tablets, that is, almost 10 times more expensive.

The article above and comments written by readers are for informational purposes only and do not encourage self-medication. Consult a specialist regarding your own symptoms and illnesses. When taking any medicine, you should always use the instructions that come with the medicine and your doctor's advice as a guide.

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Do you want to get rid of your nose, throat, lung and cold diseases? Then be sure to check it out here.

It is also worth paying attention to other drugs for colds and acute respiratory viral infections:

Should I take paracetamol? or is it better to be patient?

I want to lie down, but I'm at work.

Just in the West, buying paracetamol is not a problem in reasonable quantities.

Paracetamol and Ibuprofen are not prescribed together

And right there, in the next paragraph: - Nurofen and paracetamol are often prescribed for high temperatures. The main thing is to maintain the interval between doses.

How is that? And is it okay that Nurofen is the trade name of Ibuprofen? And how can Ibuprofen be less harmful if it is not a selective NSAID? Dear author, well, take the trouble to read before you write, at least read the history of the creation of the drug. Initially, Ibuprofen was created not as an antipyretic, but as an anti-inflammatory drug for the treatment of rheumatoid inflammation.

From 3 months of life, Ibuprofen is prescribed at a dosage of 5-10 mg/kg. Paracetamol, according to recommendations for providing positive care to children, is prescribed from the 1st day of life.

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Paracetamol: indications, contraindications, side effects

Paracetamol is a widely used antipyretic and analgesic drug belonging to the anilide group. In some countries it is sold under the name Acetaminophen. The drug does not produce the side effects characteristic of most NSAIDs, but when taken in excessively large doses, it can negatively affect the functions of the liver, kidneys and circulatory system.

Important: the risk of developing side effects (hepato- and nephrotoxic) increases many times when taking Paracetamol and liquids containing ethanol (including pharmaceutical tinctures) in parallel. In this regard, it is recommended to refrain from drinking alcohol during treatment.

The undoubted advantage of Paracetamol over Acetylsalicylic acid (Aspirin) is the low risk of exacerbation of chronic gastritis and the development of gastric and duodenal ulcers.

This central non-narcotic analgesic is considered one of the most effective and safe. It is included in the list of “Life-Saving and Essential Medicines” adopted by the Government of the Russian Federation.

Active substance and release forms

The active ingredient is para-acetaminophenol (N-(4-Hydroxyphenyl) acetamide). Chemical formula – C8H9NO2. Paracetamol was synthesized in 1877 and clinical trials took place ten years later. Sales of the drug began in 1953 under the trade name Tylenol (USA). In 1956, Panadol appeared, based on the same chemical substance. Currently, a huge number of paracetamol-containing drugs are produced, which additionally include ingredients such as caffeine, acetylsalicylic acid, codeine, analgin, etc.

Domestic pharmaceutical companies produce Paracetamol in regular tablets (200, 325 and 500 mg), film-coated tablets (Panadol Extra 325 and 500 mg), capsules (325 and 500 mg), and also in the form of rectal suppositories (50 mg each). , 100, 125, 250 and 500 mg).

Pharmacy chains sell soluble tablets of 500 mg - Efferalgan, Panadol Extra, Flutabs and Paracetamol-Hemofarm.

Popular panadol-containing drugs include powders for preparing the solution Fervex and Theraflu.

An injection form is also available - Perfalgan solution (10 mg/ml). For children, you can purchase Panadol Baby and Efferalgan Children's syrups, as well as suspensions for oral administration of Paracetamol for Children, Calpol and Daleron.

Benefits of Paracetamol

Para-acetaminophenol acts on the thermoregulation center located in the hypothalamus, making its antipyretic effect as close as possible to the process of natural decrease in body temperature. The undoubted advantage of Paracetamol over NSAIDs is its selectivity of action, which makes it possible to use it for the treatment of children. In addition, drug metabolism products very quickly leave the body naturally, which eliminates cumulation (accumulation) in organs and tissues.

Paracetamol: indications for use

Paracetamol is a drug intended to relieve symptoms. It does not affect the dynamics of the pathological process in any way. The most common indications for starting to take this drug are increased body temperature (hyperthermia) due to colds and viral diseases, as well as pain (aches) in the bones and muscles during influenza and other acute respiratory viral infections.

Diseases and pathological conditions for which acetaminophen is recommended:

Directions for use and dosage of Paracetamol

Acetaminophen produces therapeutic effects when administered in doses of IMG per 1 kg of body weight.

Oral forms of Paracetamol (tablets or syrup) are recommended to be taken 1-2 hours after meals with plenty of liquid (preferably clean water). Taking on a full stomach slows down absorption and, therefore, the development of the expected therapeutic effect.

Paracetamol in the form of suppositories is administered rectally (1 suppository).

The recommended single dosage for adult patients and adolescents over 12 years of age (or weighing over 40 kg) is 1 g (2 tablets of 0.5 g each), and the daily dosage is 4 g.

For children under 12 years of age, the dose is determined individually based on mg per 1 kg of weight (60 mg/kg per day). Frequency – up to 4 times a day; It is advisable to maintain approximately equal time intervals between doses.

For babies from 3 months. up to 1 year of age, the dosage ranges from 24 to 120 mg (up to 4 times a day), and children from 1 to 6 years of age are given pomg per dose.

It is not advisable to take Paracetamol for more than 5 days in a row. If the fever persists for more than 3 days, and the pain persists for more than 5 days, you should consult your doctor. Usually in such cases it is recommended to replace the drug with another analgesic and antipyretic. To reduce the risk of undesirable consequences, it is advisable to limit yourself to the minimum effective doses and strictly adhere to the dosage regimen.

pharmachologic effect

The active substance is able to block the enzyme cyclooxygenase (COX1 and COX2), thereby reducing the level of production of pain mediators - prostaglandins. The drug has a direct effect on the thermoregulation and pain centers located in the brain. There is reason to believe that the pronounced antipyretic and analgesic effects are due, among other things, to the selective blockade of COX 3, an enzyme that accelerates the synthesis of prostaglandins and is involved in the formation of fever and pain.

This drug has relatively weak anti-inflammatory properties, since it is neutralized by peripheral tissue peroxidases. Paracetamol does not have a negative effect on water-electrolyte metabolism.

Pharmacodynamics

After oral administration, Paracetamol is rapidly absorbed from the digestive tract. The time to reach maximum serum concentration can vary from 30 minutes. up to 2 hours. About 15% of the active substance is conjugated with plasma proteins. The drug freely passes the blood-brain barrier. Most of the substance undergoes biotransformation in the liver. The half-life is from 1 to 4 hours (in elderly patients it is slightly longer). Metabolites (sulfates and glucoronides) and para-acetaminophenol unchanged (about 3%) are excreted in the urine.

Paracetamol: contraindications

Contraindications include:

  • individual hypersensitivity (increased sensitivity) to the active substance;
  • “aspirin triad” (a combination of intolerance to NSAIDs, bronchial asthma and recurrent polyposis of the nose and paranasal sinuses);
  • inflammatory diseases, erosions and ulcers of the gastrointestinal tract;
  • gastrointestinal bleeding;
  • severe functional renal failure;
  • diagnosed hyperkalemia;
  • condition after coronary artery bypass surgery.

Important: Paracetamol-containing drugs are contraindicated in newborns in the first month of life.

Particular caution should be exercised when taking this drug in case of the following diseases and pathological conditions:

Please note: if you have diabetes, it is not recommended to take Paracetamol in syrup form.

Side effects of Paracetamol

Taking Paracetamol by a woman during pregnancy greatly increases the risk of developing such an anomaly as an undescended testicle in newborn boys (treatment of cryptorchidism often requires surgical intervention). According to a number of researchers, the drug increases the likelihood of a child developing bronchial asthma (along with Aspirin).

It is also believed that taking Paracetamol can slightly reduce the patient's emotional response.

Excessively long-term use of this drug, even in therapeutic doses, can cause the development of analgesic nephropathy, which results in severe renal failure.

What is the danger of an overdose of Paracetamol?

Almost any pharmacological drug in a certain dosage can be deadly. The toxicity of Paracetamol is relatively low, but when taken simultaneously in a dose exceeding 140 mg/kg (for adults) or 140 mg/kg (for children), serious liver damage develops. This is due to the hepatotoxic effect of intermediate products of para-acetaminophenol metabolism.

Important: death is possible when taking 40 tablets per day. Following the instructions will prevent you from taking a dangerous amount of the drug.

Significant excess of recommended dosages is one of the causes of serious bleeding in the gastrointestinal tract, requiring urgent hospitalization. If medical assistance is not provided in a timely manner, death cannot be ruled out.

In case of overdose, hemodialysis is ineffective, and forced diuresis can even be dangerous. In case of intoxication with Paracetamol, the use of glucocorticoids and antihistamines is unacceptable, since they increase the level of synthesis of metabolic products that have a negative effect on the liver.

Interaction with other drugs

It is important to be careful when using Paracetamol in parallel with anticoagulants (Warfarin), antiplatelet agents (including Acetylsalicylic acid), glucocorticosteroid hormones (Prednisolone) and serotonin reuptake inhibitors (Fluoxetine, Sertraline, etc.).

Combination with drugs containing phenobarbital (Valocordin, Corvalol) is unacceptable.

Paracetamol during pregnancy and lactation

Paracetamol should not be taken by women in the third trimester of pregnancy. In the first and second trimesters, the medicine should be taken as prescribed by the doctor; in this case, the ratio of benefit to the mother and possible risk to the fetus is taken into account.

Less than 1% of the active substance passes into breast milk, so the lactation period is not a contraindication to taking the drug.

additional information

If, due to the disease, the patient's appetite is significantly reduced, it is recommended to halve the dosage of oral forms to avoid the risk of irritation on the mucous membranes of the digestive tract.

Some drugs contain para-acetaminophenol in combination with caffeine. It has been proven that caffeine enhances the effect of Paracetamol by increasing its bioavailability. This combination is very helpful in relieving headaches due to low blood pressure.

An enhanced effect of para-acetaminophenol is achieved with the parallel intake of ascorbic acid into the body. Vitamin C slows down the removal of the active substance from the body.

Plisov Vladimir, medical observer

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Paracetamol for colds

One of the most popular antipyretic drugs today is paracetamol. For many decades, this substance has been included in many medications that people take for colds and viral diseases. In our country there are more than 200 similar remedies that alleviate a person’s condition with acute respiratory viral infections, colds, flu, and high fever. Of course, drugs containing paracetamol are sold under different brand names, but their principle of action, composition and contraindications are essentially the same.

Main symptoms of colds

Typical symptoms include:

1 High temperature, spasmodic, can be at 38 degrees;

To understand why paracetamol is chosen as the main therapeutic drug in this case, you need to consider its properties and essence in detail.

Effect of paracetamol for colds

Paracetamol is a drug with pronounced non-narcotic and antipyretic (antipyretic) activity. The drug allows you to achieve an anti-inflammatory effect with minimal possible side effects, which are typical for non-steroidal anti-inflammatory substances. The World Health Organization has included paracetamol in the list of the most important and necessary medicines for humanity.

If these properties are correlated with the usual symptoms of colds, then once again there is no need to talk about the advisability of using Paracetamol. Why is the use of this drug becoming one of the most optimal methods of fighting colds? Its advantages can tell you about this.

Benefits of paracetamol for colds

The advantages of the drug include:

1 Antipyretic effect of the drug. The effect is as close as possible to the natural process of decreasing temperature. Paracetamol acts on the central nervous system, localizing the action in the hypothalamus, carrying out thermoregulation processes. This approach will guarantee a decrease in temperature to normal, allowing, among other things, to activate the body’s defense mechanisms without stopping febrile processes;

Basic principles of treatment with paracetamol for colds

1 Paracetamol is recommended for use in acute forms of colds with severe high body temperature;

Treatment regimen for colds with paracetamol

Paracetamol can be prescribed by a doctor during the acute course of colds, of general or specific etiology, for children over 12 years of age and adults. To take the drug, the child’s weight must exceed 40 kg, because otherwise it is impossible to select an effective dose of paracetamol with a guarantee of the absence of side effects.

Oral (powders, tablets, etc.) and rectal (suppositories) use of the drug is common. Injection solutions are also sold, but their use is ineffective, so rectal and oral use of the drug can achieve quick results.

For an adult, the maximum single dosage is no more than 1 g of the drug. Adults can take no more than 4 g of the drug per day for colds (in 4-5 doses). Before taking Paracetamol, you need to wait 5 hours or more. The dose for minors should be calculated according to the child's weight. The maximum dose in these cases is 15 mg of medication per 1 kg of weight. The maximum daily dose for children should not exceed 60 mg per 1 kg of weight.

Paracetamol should be taken 2 hours after meals with liquid. If the patient does not have an appetite, it is recommended to reduce the dosage of the drug by half so that there is no irritating effect. When using the drug rectally, there is no binding to food or various restrictions.

The course of treatment for colds with Paracetamol cannot exceed 1 week. As a rule, severe symptoms in uncomplicated forms of the disease disappear after 1-2 days. For a cold, the fever will go away on the 3rd day and pain on the 5th day. If this does not happen, then you should seek help from a doctor so that complications do not develop and the disease does not become chronic.

The paracetamol treatment regimen in general looks like this:

1 The drug is taken in the above indicated dosage until the pain and fever disappear. But the duration of treatment should not exceed 7 days;

Before starting treatment with paracetamol, you need to familiarize yourself with the contraindications.

Contraindications and overdose of paracetamol for colds

The main contraindications when taking paracetamol: liver and kidney diseases, frequent consumption of alcoholic beverages, individual intolerance. In addition, the drug should be taken with caution during breastfeeding and pregnancy.

Paracetamol is practically harmless. If the patient does not have the above-mentioned conditions, and he takes the drug in an acceptable dosage with a time interval, then there can be no talk of any side effects. If the rules for taking the drug are not followed, the patient will experience an allergic reaction, abdominal pain, vomiting, nausea, overexcitation or drowsiness, renal colic, and decreased hemoglobin. An allergy to the drug is usually manifested by skin rashes, itching, and tissue swelling. Allergic reactions are more common in young children.

A certain “conflict” arises between paracetamol and the liver. The medicine is absorbed quickly enough and spreads through the blood vessels throughout the body, providing maximum effect minutes after administration. The substance is broken down in the liver, where it turns into metabolic products harmful to this organ. These metabolites can destroy liver cells. And this is facilitated by excess dosage. If the dosage of the drug is seriously and long-term exceeded, the liver generally ceases to perform its functions and the patient can only be saved by an organ transplant. If a patient has liver disease, he is prohibited from taking Paracetamol. In addition, the harmful effect of the drug is enhanced if it is taken by a person suffering from alcoholism. The combined effect of alcohol and Paracetamol immediately increases the toxicity of these substances to the liver and kidneys. The human body is not always able to withstand such loads.

It should be noted that the harm and overdose of paracetamol began to be studied much more actively precisely after the increased incidence of deaths caused by taking the drug. Most of the sufferers were young people who inadvertently took large doses of paracetamol or drugs in the correct dosage containing this substance.

Each instruction for paracetamol and any other medicine containing it states that before taking the drug, you must carefully examine the insert and take into account all the recommendations given there. In addition, a sick person does not always have indications for taking paracetamol, which also needs to be monitored separately.

Interaction of paracetamol with other drugs

1 The most common interaction is caffeine-paracetamol. This combination has a double effect on the body. The drug will lower the temperature, and caffeine increases this function of the drug by increasing the concentration of the substance in the brain cells. As a result, the antipyretic effect increases several times, in addition, the body receives energy due to the action of caffeine.

Paracetamol and caffeine are often used for low blood pressure headaches. The vasodilator and analgesic effect in this case is guaranteed. In addition, these substances are the main ones in Panadol extra tablets.

2 Another interaction is no-spa and paracetamol. These drugs do an excellent job of treating fever and headaches, especially in children. No-spa eliminates vasospasm, and paracetamol has an antipyretic effect.

3 Next, we will consider the interaction of analgin and paracetamol. In some cases, analgin will lower the temperature better than aspirin or a drug containing paracetamol. This is typical for intramuscular injections of analgin and diphenhydramine, when the desired effect comes within 15 minutes. It is worth noting that paracetamol and analgin are prohibited from being combined with other anti-inflammatory drugs.

4 Aspirin and paracetamol have essentially similar mechanisms of action. But aspirin will also thin the blood. Of course, paracetamol seems to be a safer drug than aspirin, which has many contraindications. By and large, there is no point in taking these painkillers and antipyretics at the same time, and it will put a serious burden on the liver and kidneys. It is recommended to alternate drugs in case of high temperature to avoid overdose.

5 Paracetamol and ibufen are completely different drugs in composition, but still belong to the category of painkillers and antipyretics. Ibufen, among other things, will have a serious anti-inflammatory effect, so it is considered a broader-spectrum drug. Paracetamol, in most cases, is often replaced with ibufen, because it copes better with elevated temperatures. These drugs should not be taken at the same time.

6 Paracetamol and Nurofen are always prescribed at elevated temperatures, which cannot be brought down by the action of one drug. It is important to maintain time intervals between doses of the drug. Nurofen, as a rule, acts long-lasting and effectively. In addition, Nurofen is noted to be less allergenic and cause less harm.

7 Paracetamol and suprastin are a standard drug interaction used to relieve fever in people with allergic reactions. Suprastin and paracetamol are often recommended to be taken in the period after vaccination at high temperatures. Paracetamol will have an antipyretic effect, and suprastin will have an antihistamine effect. If during the illness the doctor prescribed various drugs, then Suprastin is recommended to reduce the risk of allergies.

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Source: http://neprostudis.ru/g/paratsetamol-pri-prostude

How and why to take paracetamol for a cold

Paracetamol is the most popular remedy for colds. It can be taken by adults, and it is also recommended for children, naturally in a smaller dosage. The drug perfectly relieves fever, relieves pain from colds, and has no pronounced side effects. In addition, it is very inexpensive - one of the most effective antipyretic agents available today.

All these advantages have won paracetamol such popularity among the people. In the article we will take a closer look at this drug, find out what justifies its effect, and how to take paracetamol, and consider other questions on this topic.

Symptoms

What ailments can we consider typical manifestations of a cold?

  • Heat. Sometimes it can reach 38 degrees. If the fever becomes stronger than this borderline mark, then it makes sense to talk not about a cold, but about a more serious illness.
  • Severe weakness, general malaise, lethargy and weakness. These symptoms clearly indicate that you have a cold.
  • Runny nose, cough, frequent sneezing.
  • Often a cold is accompanied by joint and muscle pain. In this case, there is a feeling of “ache”, and sometimes “twisting” of the joints.
  • Mild headache, sometimes developing into a migraine.

All these symptoms can be effectively treated with paracetamol if treatment is started on time.

pros

The World Health Organization has long included the drug among the most necessary medicines for humanity. Let's consider what are the advantages of paracetamol.

Paracetamol has minimal side effects. This fact makes it possible to consider the drug one of the safest among modern antipyretics, although paracetamol is already known on the medicine market.

Paracetamol not only lowers the temperature, but also does it in the most natural way possible, without shocking the body. Such a gentle effect is the most gentle way to bring your health back to normal.

Paracetamol does not kill the body's defenses, but helps them cope with the disease. That is, unlike treatment with antibiotics, all beneficial microflora remains unharmed in this case.

The video shows the positive and negative sides of paracetamol:

Paracetamol has no pronounced side effects, which makes it possible to take it for quite a long time, if necessary.

The drug can be used to treat children. Even infants have their own paracetamol for children in the form of syrup.

The active substances and chemical compounds present in the drug do not settle in the body, but are quickly and completely eliminated from it. The cost of this medicine is very low. This makes paracetamol accessible to all segments of the population.

Contraindications and side effects

Let's consider in what cases it is undesirable to take paracetamol:

  • In case of chronic and acute diseases of the liver and kidneys, taking the drug is prohibited.
  • In case of individual intolerance.
  • It is forbidden to take paracetamol in combination with alcohol and with those medications that contain alcohol even in minimal quantities.
  • If you are pregnant or breastfeeding, use caution.

In the video, paracetamol at the first signs of a cold:

Side effects

It should be noted that if you follow the dosage, the drug will not cause any side effects.

But in case of overdose, the following symptoms may occur:

  • Allergic skin rashes. More often in children.
  • Abdominal pain.
  • Vomiting, nausea.
  • Sometimes an overdose leads to overexcitation, and in some cases, on the contrary, to drowsiness.
  • Colic in the kidneys.
  • Decreased hemoglobin levels.

Attention: if you have liver disease, paracetamol should not be taken. If the dosage is seriously exceeded, the drug comes into conflict with the liver. Doctors have recorded cases where a significant overdose led to complete failure of the organ. In this case, only an urgent transplant can help.

How it works

Let's consider what effect the drug has on the body of a person with a cold.

  • Paracetamol is known primarily for its ability to quickly reduce fever. This is what it is most often used for.
  • The drug “calms down” the inflammatory process that led to the onset of the disease.
  • Paracetamol relieves attacks of pain, including headaches and muscle pain.

As you can see, the drug has a complex effect. Therefore, we can quite reasonably talk about its obvious effectiveness.

In the video, can a nursing mother take paracetamol for a cold:

How to use

The drug can be used for acute cold symptoms. It is also effective in the chronic course of the disease when there is no high temperature. What recommendations should you follow when taking paracetamol?

Paracetamol in its usual form is prescribed to adults and children over 12 kg who weigh more than 40 kg. For children, there is a special paracetamol with a reduced concentration of the active substance.

The drug is taken orally. Most often it is available in the form of tablets, but it also comes in powders, capsules, and syrups (for children). There is also paracetamol in the form of rectal suppositories. The drug in the form of injections is ineffective, so this method is not in great demand.

An adult can take no more than one gram of the drug at a time. And per day - no more than 4 grams. For a child, the limit is 60 mg per 1 kg of weight. More than this amount of paracetamol should not be given to a child.

It is recommended to take the product when at least 2 hours have passed since the last meal. The tablets are taken with plain water.

If the patient does not want or cannot eat, it is recommended to reduce the dosage of paracetamol by half to prevent irritation of the stomach walls. The drug administered rectally does not require compliance with any restrictions on the time of eating.

It is recommended to treat with this medicine for no more than a week. In most cases, after 2-3 days of taking the drug, all the most acute cold symptoms disappear. And the pain will completely disappear on the fifth day of use.

Attention: if cold symptoms do not subside after 2-3 days of taking paracetamol, you should definitely consult a doctor. You may have a more serious illness than a cold.

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Preparations with paracetamol

The active substance, paracetamol, is found in at least 179 different broad-spectrum medications. Here are examples of several of them that are effective for colds.

Panadol

This drug is a combination of paracetamol and caffeine, two active substances. This precisely calculated combination helps Panadol effectively and quickly cope with colds and viral infections.

panadol for colds

The drug perfectly reduces temperature and relieves pain. There is a children's version of the drug.

Daleron S

This is a “hybrid” of ascorbic acid and paracetamol. Available in the form of granules or soluble powder. The drug perfectly relieves fever and relieves pain. Effective for cold fever, mild and moderate pain symptoms.

Daleron C for the treatment of colds and flu

In addition to colds, it can be used to treat toothache, migraine, and painful periods.

Pyranol plus

The composition of this drug is more complicated. In addition to paracetamol, chlorphenamine, pseudoephedrine and dextromethorphan are also present. The product perfectly relieves pain and removes high fever. Effective against colds and flu.

Relieves all symptoms associated with these diseases. Thanks to the drug, cough disappears, runny nose, nasal congestion go away, and it even copes with severe feverish conditions.

Combination with other drugs

How does the effect of paracetamol increase or change when combined with other drugs?

Caffeinated

If you combine these two components, the anti-cold effectiveness of the product can be doubled. As a result, the temperature drops much faster, and due to the energetic effects of caffeine, lethargy and apathy disappear.

In addition, the combination relieves headaches and has a vasodilating effect. This combination is presented in the drug Panadol Extra.

With no-shpa

Drugs containing this combination are excellent in reducing fever. They are also effective for headaches. These drugs have a particularly pronounced positive effect when treating children. No-spa in this combination relieves vasospasm, and paracetamol removes fever.

Video of medications with paracetamol for colds:

With analgin

Such drugs very quickly relieve fever. Much faster than the effect of one of them. Therefore, this is a solution in cases where it is impossible to delay reducing the temperature.

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Attention: it is prohibited to combine this combination with other medications.

With aspirin

Both of these components have similar effects. However, aspirin also thins the blood. Paracetamol is safer than aspirin. In most cases, there is no point in taking them together. But this article will help you understand how to take aspirin for a cold, and how effective this remedy is.

In addition, the liver and kidneys will be under too much stress. However, although it is not recommended to take them at the same time, they can be alternated for more effective relief from cold symptoms.

Reviews

What do people who use paracetamol for treatment say?

  • Olga, 35 years old: “I have a responsible job, a mortgage, small children - it’s absolutely impossible to get sick. Therefore, at the first sign of a cold, I always take paracetamol - I always have it in my purse. The symptoms go away quickly - after a couple of days I am completely healthy. So far the drug has not let me down. I advise everyone - this is exactly what you need for a cold.”
  • Nadezhda, 24 years old: “My child and I are being treated for a cold with paracetamol. It is inexpensive, always helps, and has no side effects if the dosage is followed correctly. So far I have no complaints - the drug always relieves fever perfectly, aches and headaches also go away quickly. In my opinion, this is a great choice for anyone who wants to get rid of a cold without spending a ton of money on treatment.”

We reviewed all the features, advantages and effects of paracetamol. As you can see, the drug deserves attention due to its undoubted effectiveness, minimal side effects and inexpensive price. Therefore, now you know what to do when you have a cold. It is better if you always have paracetamol in your home medicine cabinet - in this case, you can start treatment immediately at the first signs of illness.

Even pregnant women are allowed to take paracetamol when the temperature rises too high. In general, you need to remember that you can bring down the temperature only after 38, if you bring it down below 38, then the disease, on the contrary, will drag on. But Paracetamol does not always help at such a high temperature (at least for me), so you have to constantly monitor it and keep other remedies at the ready.

Source: http://prolor.ru/n/lechenie-n/paracetamol-pri-prostude.html