What is rimantadine avexima for?

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Rimantadine

Rimantadine: instructions for use and reviews

Latin name: Rimantadine

ATX code: J05AC02

Active ingredient: rimantadine

Manufacturer: Irbit Chemical and Pharmaceutical Plant, JSC (Russia), Biosynthesis (Russia), Usolye-Sibirsky Chemical Plant, JSC (Russia), PharmVILAR NPO (Russia), Moskhimfarmpreparaty im.

Table of contents:

N. A. Semashko (Russia), Ozon, LLC (Russia), Europharm, CJSC (Russia), Tatkhimfarmpreparaty, JSC (Russia), Marbiopharm (Russia)

Update of description and photo: 12/26/2017

Prices in pharmacies: from 20 rubles.

Rimantadine is an antiviral agent.

Release form and composition

Dosage form - tablets: round, white or almost white, with a bevel, possibly with a score (10, 20 or 30 pcs. in blister packs, in a cardboard pack of 1, 2, 3, 4, 5, 6, 8 or 10 packs; 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 pcs. in polymer cans, 1 can in a cardboard pack; packaging for hospitals - in a cardboard box 200, 400, 500, 600, 800, 1000 blister packs).

Composition of 1 tablet:

  • active substance: rimantadine hydrochloride – 50 mg;
  • excipients (may vary slightly from one manufacturer to another): calcium stearate, lactose monohydrate, talc, potato starch.

Pharmacological properties

Pharmacodynamics

Rimantadine is an antiviral agent derived from adamantane. Effective against various strains of influenza A virus (especially A2).

Thanks to the polymer structure, long-term circulation of rimantadine in the body is ensured, so the drug is used not only for treatment, but also for the prevention of influenza.

Rimantadine suppresses the early stage of specific virus reproduction (after its entry into the cell and before the initial transcription of RNA).

Rimantadine is a weak base. Its effect is due to the ability to increase the pH of endosomes, which have a vacuole membrane and surround viral particles after they enter the cell. Thus, the drug substance prevents acidification in these vacuoles, which blocks the fusion of the viral envelope with the endosomal membrane and, as a result, interrupts the transcription of the viral genome, i.e., prevents the transfer of viral genetic material into the cell cytoplasm.

When taking rimantadine in a daily dose of 200 mg for 2-3 days before and for 6-7 days after the development of clinical symptoms of influenza A, the incidence, severity of symptoms and the degree of serological reactions are reduced. Some therapeutic effect of the drug is possible if it is taken within the next 18 hours after the first signs of influenza appear.

Pharmacokinetics

After oral administration, rimantadine is slowly but almost completely absorbed from the intestine. Approximately 40% bound to plasma proteins. Its volume of distribution is 17–25 l/kg in adults, 289 l/kg in children.

In nasal secretions, the concentration of the drug is 50% higher than in blood plasma. Maximum plasma concentrations: 181 ng/ml – when taking a daily dose of 100 mg, 416 ng/ml – when taking a daily dose of 200 mg.

Metabolized in the liver. It is excreted by the kidneys mainly in the form of metabolites (75–85%), partially unchanged (15%). The half-life is 24–36 hours, but increases by 2 times in patients with concomitant chronic renal failure.

In renal failure and in elderly patients, accumulation of rimantadine in toxic concentrations is possible unless the dose is adjusted in proportion to the decrease in creatinine clearance.

Indications for use

According to the instructions, Rimantadine is used for the early treatment and prevention of influenza A in children over 7 years of age and adults.

Prophylactic administration is recommended after contact with a sick person (recommended for at least 10 days), in case of spread of infection in closed groups, as well as in the presence of a high risk of illness during an influenza epidemic.

Contraindications

  • acute and chronic kidney diseases;
  • acute liver diseases;
  • thyrotoxicosis;
  • glucose-galactose malabsorption, lactase deficiency, lactose intolerance;
  • children under 7 years of age;
  • period of pregnancy and breastfeeding;
  • the presence of hypersensitivity to any component of the drug.

The antiviral agent should be used with caution in diseases of the gastrointestinal tract, liver failure, arterial hypertension, cerebral atherosclerosis, epilepsy (including a history), as well as in old age.

Instructions for use of Rimantadine: method and dosage

Rimantadine tablets are taken orally, after meals, with water.

Recommended prophylactic dosing regimens:

  • adults: 50 mg once a day for up to 30 days;
  • children over 7 years old: 50 mg once a day for up to 15 days.

The duration of treatment is determined by the epidemiological situation.

For the flu, you should start taking Rimantadine within the first 24–48 hours after the first symptoms of the disease appear.

Scheme for prescribing the drug to adults and adolescents over 14 years of age by day:

  • Day 1 – 100 mg 3 times a day or 300 mg once;
  • Day 2 – 100 mg 2 times a day;
  • 3rd day – 100 mg 2 times a day;
  • 4th day – 100 mg 1 time per day;
  • Day 5 – 100 mg 1 time per day.

For medicinal purposes, doses for children over 7 years of age are determined depending on age:

  • 7–10 years – 50 mg 2 times a day;
  • 10–14 years – 50 mg 3 times a day.

The duration of treatment is also 5 days.

Elderly patients and patients with concomitant chronic renal/liver failure, as well as persons suffering from epilepsy, are prescribed rimantadine 100 mg once a day for the treatment of influenza.

Side effects

  • from the respiratory system: shortness of breath, cough, bronchospasm;
  • from the nervous system: movement disorders, fatigue, headache, insomnia, impaired concentration, confusion, depressed mood, irritability, hyperkinesia, drowsiness, hallucinations, dizziness, tremor, euphoria, convulsions;
  • from the gastrointestinal tract: dryness of the oral mucosa, loss of appetite, nausea, diarrhea, abdominal pain, vomiting, dyspepsia;
  • from the cardiovascular system: loss of consciousness, cerebrovascular accident, arterial hypertension, heart block (heart rhythm disturbance), tachycardia, palpitations, heart failure;
  • from the senses: loss or change in sense of smell, tinnitus;
  • other: fatigue, rash.

Overdose

Symptoms: arrhythmia, hallucinations, agitation. Dry skin, eye pain, watery eyes, inflammation of the oral mucosa, sweating, constipation, increased urination, and fever are also possible.

The first measure in case of overdose is gastric lavage. Further treatment is symptomatic, aimed, among other things, at maintaining the vital functions of the body. In case of development of negative symptoms from the nervous system, intravenous administration of physostigmine (1.2 mg for adults and 0.5 mg for children) is indicated; if necessary, the drug is re-administered (no more than 2 mg/hour). Rimantadine can be partially removed by hemodialysis.

special instructions

It is advisable to take the drug to prevent influenza after contact with a sick family member. However, it is less effective for prophylactic use in families in which people with influenza took rimantadine for prophylactic purposes, which is likely due to the transmission of viruses resistant to its action.

For influenza caused by virus B, rimantadine has antitoxic activity.

During the period of antiviral treatment, exacerbation of existing chronic diseases is possible. Older people with arterial hypertension are more likely to develop hemorrhagic stroke. Patients with a history of epilepsy and anticonvulsant therapy are at increased risk of having a seizure. In such cases, Rimantadine is prescribed in a daily dose of 100 mg simultaneously with anticonvulsant therapy.

The possibility of the emergence of viruses resistant to the drug should be taken into account.

Impact on the ability to drive vehicles and complex mechanisms

Due to the risk of developing side effects from the central nervous system, during the entire period of taking the drug, care must be taken when performing potentially hazardous types of work that require increased attention and speed of reactions (including driving vehicles).

Use during pregnancy and lactation

Rimantadine tablets are contraindicated for use throughout pregnancy and lactation.

Use in childhood

This dosage form of the drug is not intended for the treatment of children under 7 years of age.

For impaired renal function

The presence of acute and chronic kidney disease is a contraindication to the use of Rimantadine.

In case of renal failure, the dose is reduced in proportion to the level of creatinine clearance.

For liver dysfunction

In acute liver diseases, the use of the drug is prohibited. In case of liver failure, the drug should be used with caution.

Use in old age

Elderly patients should be under close medical supervision during treatment. A dose reduction is required.

Drug interactions

Rimantadine reduces the effect of antiepileptic drugs.

The influence of other drugs on the action of rimantadine:

  • adsorbents, enveloping and astringent agents reduce absorption;
  • cimetidine reduces clearance by 18%;
  • acetylsalicylic acid and paracetamol reduce the maximum concentration (by 10 and 11%, respectively);
  • agents that acidify urine (including ammonium chloride, sodium bicarbonate, diacarb, acetazolamide, ascorbic acid) increase excretion by the kidneys and, as a result, reduce the effect.

Analogs

Analogues of Rimantadine are: Orvirem, Remantadine, Rimantadine Avexima, Rimantadine Actitab.

Terms and conditions of storage

Store in a dry place, protected from light, out of reach of children at temperatures up to 25 °C.

Shelf life – 3 or 5 years (depending on the manufacturer).

Conditions for dispensing from pharmacies

Available without a prescription.

Reviews of Rimantadine

According to reviews, Rimantadine is an antiviral agent that is effective both in the early treatment of influenza and for its prevention after contact with a patient or after being in a closed group where there are people with influenza.

Additional advantages include the low price of the drug and its good tolerability. Side effects, according to patients, occur rarely and usually in case of individual intolerance.

Price for Rimantadine in pharmacies

The approximate price for Rimantadine for a package of 20 tablets is 29–54 rubles.

Rimantadine tab. 50mg n20

Rimantadine tab. 50mg n20

Rimantadine tablets 50 mg 20 pcs.

Rimantadine tab. 50mg n20

Rimantadine 50 mg No. 20 tablets jar

Rimantadine 50 mg No. 20 tab

Rimantadine 50 mg No. 20 tablet

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Source: http://www.neboleem.net/rimantadin.php

RIMANTADINE AVEXIMA

◊ White, flat-cylindrical tablets

Excipients: lactose (milk sugar) - 60 mg, potato starch - 37 mg, calcium stearate - 1.5 mg, talc - 1.5 mg.

10 pieces. — contour cell packaging (2) — cardboard packs.

20 pcs. — cellular contour packages (1) — cardboard packs.

20 pcs. — polymer jars (1) — cardboard packs.

Rimantadine is active against various strains of influenza A virus. Being a weak base, rimantadine acts by increasing the pH of endosomes, which have membrane vacuoles that surround viral particles after they enter the cell. Preventing acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thus preventing the transfer of viral genetic material into the cell cytoplasm. Rimantadine also inhibits the release of viral particles from the cell, i.e. interrupts transcription of the viral genome.

After oral administration, rimantadine is almost completely absorbed from the intestine. Absorption is slow. Communication with plasma proteins is about 40%. V d : adults l/kg, children. The concentration in nasal secretions is 50% higher than in plasma. Cmax of the active substance in blood plasma at a dose of 100 mg 1 time/day/ml, at 100 mg 2 times/day/ml. Metabolized in the liver. T 1/2 h; 75-85% of the dose taken is excreted by the kidneys, mainly in the form of metabolites, 15% - unchanged.

In chronic renal failure, T1 /2 increases by 2 times. In persons with renal failure and in the elderly, toxic concentrations may accumulate if the dose is not adjusted in proportion to the decrease in clearance.

- acute liver diseases;

— acute and chronic kidney diseases;

- hypersensitivity to rimantadine;

— pregnancy and lactation;

- for lactase deficiency, lactose intolerance, lactose/isomaltose malabsorption syndrome (since the drug contains lactose).

With caution: with arterial hypertension, cerebral atherosclerosis, liver failure, epilepsy, gastrointestinal diseases.

Orally after meals with water. Treatment for influenza should begin within a few days after the onset of symptoms.

Adults are prescribed 100 mg 3 times a day on the first day; on the second and third days, 100 mg 2 times a day; on the fourth and fifth days, 100 mg 1 time/day. On the first day of the disease, it is possible to use the drug once at a dose of 300 mg.

Children aged 7 to 10 years are prescribed 50 mg 2 times a day; from 11 to 14 years - 50 mg 3 times / day. Over 14 years of age - adult doses.

Take within 5 days.

To prevent influenza, adults are prescribed 50 mg 1 time / day for up to 30 days. Children over 7 years old - 50 mg 1 time / day for up to 15 days.

From the digestive system: dry mouth, nausea, vomiting, loss of appetite, epigastric pain, flatulence.

From the central nervous system: headache, dizziness, insomnia, neurological reactions, impaired concentration, drowsiness, anxiety, increased excitability, fatigue.

Other: hyperbilirubinemia, allergic reactions (skin rash, itching, urticaria).

Symptoms: agitation, hallucinations, arrhythmia.

Treatment: gastric lavage, symptomatic therapy: measures to maintain vital functions. Rimantadine is partially eliminated by hemodialysis.

Paracetamol and ascorbic acid reduce the maximum concentration of rimantadine in blood plasma by 11%.

Cimetidine reduces the clearance of rimantadine by 18%.

Adsorbents, astringents and coating agents reduce the absorption of rimantadine.

Urine alkalizing agents (acetazolamide, sodium bicarbonate, etc.) increase the effectiveness of rimantadine due to a decrease in its excretion by the kidneys.

When using rimantadine, exacerbation of chronic concomitant diseases is possible. Elderly patients with arterial hypertension have an increased risk of developing hemorrhagic stroke.

If there is a history of epilepsy and ongoing anticonvulsant therapy while using rimantadine, the risk of developing an epileptic seizure increases. In such cases, rimantadine is used at a dose of 100 mg/day simultaneously with anticonvulsant therapy.

For influenza caused by virus B, rimantadine has an antitoxic effect.

Prophylactic administration is effective during contacts with sick people, during the spread of infection in closed groups and at a high risk of developing the disease during an influenza epidemic.

Viruses resistant to the drug may emerge.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

The use of the drug in children under 7 years of age is prohibited.

Children aged 7 to 10 years are prescribed 50 mg 2 times a day; from 11 to 14 years - 50 mg 3 times / day. Over 14 years of age - adult doses.

For the prevention of influenza in children over 7 years of age - 50 mg 1 time / day for up to 15 days.

The use of the drug in patients with acute liver diseases is prohibited.

Use with caution in case of liver failure.

The drug should be stored in a dry place, protected from light and out of reach of children, at a temperature not exceeding 25°C.

Shelf life: 5 years.

To ask a question about the project or contact the editors, use this form.

Source: http://health.mail.ru/drug/rimantadin_aveksima/

Rimantadine Avexima - official instructions for use

Registration number:

Trade name of the drug:

INN or group name:

Dosage form:

Compound:

active ingredients: Rimantadine hydrochloride – 50 mg;

excipients: lactose (milk sugar) – 60 mg, potato starch – 37 mg, calcium stearate – 1.5 mg, talc – 1.5 mg.

Tablets are white, flat-cylindrical in shape.

Pharmacotherapeutic group:

Pharmacological properties

Rimantadine is active against various strains of influenza A virus. Being a weak base, rimantadine acts by increasing endosomes, which are membrane-bound vacuoles that surround viral particles after they enter the cell. Preventing acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thereby preventing the transfer of viral genetic material into the cell cytoplasm. Rimantadine also inhibits the release of viral particles from the cell, i.e. interrupts transcription of the viral genome.

After oral administration, rimantadine is almost completely absorbed from the intestine. Absorption is slow. Communication with plasma proteins is about 40%. Volume of distribution: adults – l/kg, children – 289 l. The concentration in nasal secretions is 50% higher than in plasma. The maximum concentration (C) of the active substance in the blood plasma at a dose of 100 mg once a day is 181 ng/ml, at 100 mg twice a day – 416 ng/ml. Metabolized in the liver. Half-life – hours; 75-85% of the dose taken is excreted by the kidneys, mainly in the form of metabolites, 15% - unchanged.

In chronic renal failure, the half-life increases by 2 times. In persons with renal insufficiency and in the elderly, toxic concentrations may accumulate if the dose is not adjusted in proportion to the decrease in creatinine clearance (CC).

Indications for use

Prevention and early treatment of influenza A in adults and children over 7 years of age.

Contraindications

  • acute liver diseases,
  • acute and chronic kidney diseases,
  • thyrotoxicosis,
  • hypersensitivity to rimantadine,
  • pregnancy and lactation period,
  • children under 7 years old,
  • for lactase deficiency, lactose intolerance, lactose/isomaltose malabsorption syndrome (since the drug contains lactose).

With caution: with arterial hypertension, cerebral atherosclerosis, liver failure, epilepsy, diseases of the gastrointestinal tract.

Directions for use and doses

Treatment for influenza should begin within the time symptoms appear.

Adults are prescribed 100 mg 3 times a day on the first day; on the second and third days, 100 mg 2 times a day; on the fourth and fifth days, 100 mg once a day. On the first day of the disease, it is possible to use the drug once at a dose of 300 mg.

Children aged 7 to 10 years are prescribed 50 mg 2 times a day; from 11 to 14 years – 50 mg 3 times a day. Over 14 years old - adult doses. Take within 5 days.

To prevent influenza, adults are prescribed 50 mg once a day for up to 30 days. Children over 7 years old - 50 mg 1 time per day for up to 15 days.

Side effect

from the digestive system: dry mouth, nausea, vomiting, loss of appetite, epigastric pain, flatulence;

from the central nervous system: headache, dizziness, insomnia, neurological reactions, impaired concentration, drowsiness, anxiety, increased excitability, fatigue;

other: hyperbilirubinemia, allergic reactions (skin rash, itching, urticaria).

Overdose

Symptoms: agitation, hallucinations, arrhythmia.

Treatment: gastric lavage, symptomatic therapy: measures to maintain vital functions. Rimantadine is partially eliminated by hemodialysis.

Interaction with other drugs Rimantadine reduces the effectiveness of antiepileptic drugs. Paracetamol and ascorbic acid reduce the maximum concentration of rimantadine in blood plasma by 11%. Cimetidine reduces the clearance of rimantadine by 18%.

Adsorbents, astringents and coating agents reduce the absorption of rimantadine.

Urine alkalizing agents (acetazolamide, sodium bicarbonate, etc.) increase the effectiveness of rimantadine due to a decrease in its excretion by the kidneys.

special instructions

When using rimantadine, exacerbation of chronic concomitant diseases is possible. Elderly patients with arterial hypertension have an increased risk of developing hemorrhagic stroke.

If there is a history of epilepsy and ongoing anticonvulsant therapy while using rimantadine, the risk of developing an epileptic seizure increases. In such cases, rimantadine is used at a dose of 100 mg per day simultaneously with anticonvulsant therapy.

For influenza caused by virus B, rimantadine has an antitoxic effect. Prophylactic administration is effective during contacts with sick people, during the spread of infection in closed groups and at a high risk of developing the disease during an influenza epidemic. Viruses resistant to the drug may emerge.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Release form

10 or 20 tablets per blister pack.

20 tablets per jar made of polymer materials.

2 blister packs of 10 tablets each, or 1 blister pack of 20 tablets each, or 1 jar of polymer materials together with instructions for use are placed in a cardboard pack.

Storage conditions

Keep out of the reach of children.

Best before date

Do not use the drug after the expiration date.

Conditions for dispensing from pharmacies

Manufacturer/organization accepting claims

OJSC "Irbit Chemical Pharmaceutical Plant"

623856, Russia, Sverdlovsk region, Irbit, st. Kirova, 172

Sverdlovsk region, Irbit, st. Karla Marksa, 124-a;

Sverdlovsk region, Irbit, st. Zavodskaya, 2.

Source: http://medi.ru/instrukciya/rimantadin-aveksima_8160/

Rimantadine avexima

Release forms

Storage: 15-25C (room temperature)

Shelf life: 60 months.

Patient reviews of rimantadine avexime

I bought this medicine at an inexpensive price as soon as I started to get sick. Within two days I was already healthy, even though I only drank for 2 days, once a day.

Personally, I am very skeptical about antiviral drugs; for colds, I usually use symptomatic teas or tablets with a similar composition, and in rare cases, when some complications begin, I take an antibiotic. But this time my mother convinced me to take rimantadine avexima. At the first symptoms, I started taking it, I won’t say that I recovered immediately, but my symptoms were much weaker than usual and instead of the usual 10-7 days, my ARVI went away in 5 days. I don’t know, maybe it was a coincidence or the drug really works, although I read that the virus this year is especially fierce and not a single drug that can be bought at the pharmacy can stop it.

Instructions for use of rimantadine avexima

pharmachologic effect

Rimantadine is active against various strains of influenza A virus. Being a weak base, rimantadine acts by increasing the pH of endosomes, which have membrane vacuoles that surround viral particles after they enter the cell. Preventing acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thus preventing the transfer of viral genetic material into the cell cytoplasm. Rimantadine also inhibits the release of viral particles from the cell, i.e. interrupts transcription of the viral genome.

Pharmacokinetics

After oral administration, rimantadine is almost completely absorbed from the intestine. Absorption is slow. Communication with plasma proteins is about 40%. V d : adults l/kg, children. The concentration in nasal secretions is 50% higher than in plasma. Cmax of the active substance in blood plasma at a dose of 100 mg 1 time/day/ml, at 100 mg 2 times/day/ml. Metabolized in the liver. T 1/2 h; 75-85% of the dose taken is excreted by the kidneys, mainly in the form of metabolites, 15% - unchanged.

In chronic renal failure, T1 /2 increases by 2 times. In persons with renal failure and in the elderly, toxic concentrations may accumulate if the dose is not adjusted in proportion to the decrease in clearance.

Release form, composition and packaging

White, flat-cylindrical tablets

Excipients : lactose (milk sugar) - 60 mg, potato starch - 37 mg, calcium stearate - 1.5 mg, talc - 1.5 mg.

10 pieces. — contour cell packaging (2) — cardboard packs.

20 pcs. — cellular contour packages (1) — cardboard packs.

20 pcs. — polymer jars (1) — cardboard packs.

Dosage regimen

Orally after meals with water. Treatment for influenza should begin within a few days after the onset of symptoms.

Adults are prescribed 100 mg 3 times a day on the first day; on the second and third days, 100 mg 2 times a day; on the fourth and fifth days, 100 mg 1 time/day. On the first day of the disease, it is possible to use the drug once at a dose of 300 mg.

Children aged 7 to 10 years are prescribed 50 mg 2 times a day; from 11 to 14 years - 50 mg 3 times / day. Over 14 years of age - adult doses.

Take within 5 days.

To prevent influenza, adults are prescribed 50 mg 1 time / day for up to 30 days. Children over 7 years old - 50 mg 1 time / day for up to 15 days.

Overdose

Symptoms: agitation, hallucinations, arrhythmia.

Treatment: gastric lavage, symptomatic therapy: measures to maintain vital functions. Rimantadine is partially eliminated by hemodialysis.

Drug interactions

Rimantadine reduces the effectiveness of antiepileptic drugs.

Paracetamol and ascorbic acid reduce the maximum concentration of rimantadine in blood plasma by 11%.

Cimetidine reduces the clearance of rimantadine by 18%.

Adsorbents, astringents and coating agents reduce the absorption of rimantadine.

Urine alkalizing agents (acetazolamide, sodium bicarbonate, etc.) increase the effectiveness of rimantadine due to a decrease in its excretion by the kidneys.

Side effect

From the digestive system: dry mouth, nausea, vomiting, loss of appetite, epigastric pain, flatulence.

From the central nervous system: headache, dizziness, insomnia, neurological reactions, impaired concentration, drowsiness, anxiety, increased excitability, fatigue.

Other: hyperbilirubinemia, allergic reactions (skin rash, itching, urticaria).

Indications

Contraindications for use

- acute liver diseases;

— acute and chronic kidney diseases;

- hypersensitivity to rimantadine;

— pregnancy and lactation;

- for lactase deficiency, lactose intolerance, lactose/isomaltose malabsorption syndrome (since the drug contains lactose).

With caution: with arterial hypertension, cerebral atherosclerosis, liver failure, epilepsy, gastrointestinal diseases.

Use for liver dysfunction

The use of the drug in patients with acute liver diseases is prohibited.

Use with caution in case of liver failure.

Use for renal impairment

Use in children

The use of the drug in children under 7 years of age is prohibited.

Children aged 7 to 10 years are prescribed 50 mg 2 times a day; from 11 to 14 years - 50 mg 3 times / day. Over 14 years of age - adult doses.

For the prevention of influenza in children over 7 years of age - 50 mg 1 time / day for up to 15 days.

Use in elderly patients

special instructions

When using rimantadine, exacerbation of chronic concomitant diseases is possible. Elderly patients with arterial hypertension have an increased risk of developing hemorrhagic stroke.

If there is a history of epilepsy and ongoing anticonvulsant therapy while using rimantadine, the risk of developing an epileptic seizure increases. In such cases, rimantadine is used at a dose of 100 mg/day simultaneously with anticonvulsant therapy.

For influenza caused by virus B, rimantadine has an antitoxic effect.

Prophylactic administration is effective during contacts with sick people, during the spread of infection in closed groups and at a high risk of developing the disease during an influenza epidemic.

Viruses resistant to the drug may emerge.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Source: http://protabletky.ru/rimantadine-avexima/

What does Rimantadine tablets help with: instructions for use by adults and children, reviews

Rimantadine is one of the pioneering drugs in the treatment of influenza and other viral diseases. During cold seasons, when the risk of contracting such a disease is especially high, rimantadine tablets come to the aid of entire families. What do they help with and how to take them correctly to protect against diseases?

Effect of the drug

For decades now, many people have preferred Rimantadine Avexima tablets. What do they help with? The drug is classified as antiviral. It first appeared on the US pharmacological market in 1963, when specialists managed to synthesize the chemical compound adamantane. In nature, this substance can only be found in oil.

The pharmacological effect of the drug is based on preventing the penetration of influenza and other viruses into healthy cells, as well as blocking the release of microorganism particles in the event of infection. In addition to the antiviral effect, the medicine also has an antitoxic effect. The half-life of Rimantadine is quite long. The tablets are absorbed into the intestines and metabolized in the liver.

All these properties of the drug allow it to be taken for both therapeutic and preventive purposes.

Instructions for use of Rimantadine tablets

For an adult, a medicinal product based on adamantane derivatives may be useful in a number of cases. However, when taking it you should be careful, because there is a certain list of contraindications and possible side effects. And now about this in more detail.

Rimantadine tablets: what do they help with?

Among the indications for the use of an antiviral drug are the following:

  • treatment of influenza type A;
  • preventive measures against influenza A virus;
  • reducing the degree of intoxication of the body due to viral diseases;
  • prevention of tick-borne encephalitis.

Regarding the treatment of influenza conditions, it is worth noting that the drug is especially effective in the early stages.

Speaking about this drug, it is worth raising the question of what Remantadine helps with. The two drugs are very similar in spelling of the name and have a common active ingredient - rimantadine hydrochloride. The drugs are interchangeable and their purposes are the same. The main difference between the “twins” is that the effect of Remantadine has been studied to a greater extent; this drug has fewer contraindications and side effects. For example, Remantadine is safer for children and can be used by women during pregnancy and lactation.

Reception features

Rimantadine tablets or capsules should be taken after meals. They are swallowed without crushing and washed down with plenty of water. For the effective effect of the drug on the body of an adult or adolescent over 14 years of age, the following dosages are recommended:

  • on the first day of illness you need to take 2 tablets 3 times a day;
  • on the second and third days, drink 2 tablets 2 times a day;
  • on the fourth and fifth days you need to take 2 tablets once a day;
  • To prevent diseases, take 1 tablet once a day for 1-2 weeks.

The duration of treatment is 5 days. The drug should be taken at the first sign of flu.

Main contraindications

The drug has a fairly wide range of contraindications, which are very important to study before starting use. Tablets should not be used:

  • children under 7 years of age;
  • for acute and chronic kidney diseases;
  • for acute liver pathologies;
  • if you are intolerant to lactose or other components of the drug;
  • during pregnancy or breastfeeding.

In addition, it is important to consider conditions for which the drug is taken with increased caution. Before taking Rimantadine, you should consult your doctor if:

  • epilepsy;
  • liver failure;
  • diseases of the gastrointestinal tract;
  • chronic renal failure;
  • arterial hypertension;
  • atherosclerosis.

Side effects

When starting to take Rimantadine, you should take note of possible side effects. With a small probability, the following effects of the antiviral drug can be observed:

  • sleep disorders;
  • headache;
  • state of anxiety;
  • dizziness;
  • feeling tired and overwhelmed;
  • excessive excitability;
  • loss of appetite;
  • attacks of nausea;
  • pain in the intestines;
  • dry mouth;
  • itching and redness on the skin;
  • hives.

Carefully following the instructions for using Rimantadine tablets will help adults quickly get rid of viral diseases and prevent possible complications.

Patient reviews of Rimantadine tablets

Data on the use of the drug Rimantadine from different groups of patients indicate mainly positive effects. First of all, in the responses, people note the high effectiveness of the drug as a means of preventing influenza in places with an increased risk of infection. For example, being in the same room with patients, they did not get sick.

As for side effects, patients mention them extremely rarely. These data are confirmed by experts and indicate that the drug is well tolerated and safe if the indicated dosages are followed.

Knowing how Rimantadine tablets can be useful and what the nuances of taking it are, you can effectively treat and prevent influenza conditions. Taking such a drug is one of the best and most affordable ways to protect yourself from viral infections during and outside of epidemics.

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Source: http://ladyspecial.ru/zdorovie/narodnaya-mediczina/lekarstva-iz-apteki/tabletki-rimantadina-ot-chego-oni-pomogayut

Rimantadine Avexima

Manufacturer: JSC Avexima Russia

PBX code: J05AC02

Release form: Solid dosage forms. Pills.

General characteristics. Compound:

Active ingredient: rimantadine 50 mg.

Excipients: lactose (milk sugar), potato starch, calcium stearate, talc.

Rimantadine is active against various strains of influenza A virus.

Pharmacological properties:

Pharmacodynamics. Being a weak base, rimantadine acts by increasing the pH of endosomes, which are membrane-bound vacuoles that surround viral particles after they enter the cell. Preventing acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thus preventing the transfer of viral genetic material into the cell cytoplasm. Rimantadine also inhibits the release of viral particles from the cell, i.e. interrupts transcription of the viral genome.

Pharmacokinetics. After oral administration, rimantadine is almost completely absorbed from the intestine. Absorption is slow. Communication with plasma proteins is about 40%. Vd: adults l/kg, children. The concentration in nasal secretions is 50% higher than in plasma. Cmax of the active substance in blood plasma at a dose of 100 mg 1 time/day/ml, at 100 mg 2 times/day/ml. Metabolized in the liver. T1/h; 75-85% of the dose taken is excreted by the kidneys, mainly in the form of metabolites, 15% - unchanged.

In chronic renal failure, T1/2 increases by 2 times. In persons with renal failure and in the elderly, toxic concentrations may accumulate if the dose is not adjusted in proportion to the decrease in clearance.

Indications for use:

— prevention and early treatment of influenza A in adults and children over 7 years of age.

Directions for use and dosage:

Orally after meals with water. Treatment for influenza should begin within a few days after the onset of symptoms.

Adults are prescribed 100 mg 3 times a day on the first day; on the second and third days, 100 mg 2 times a day; on the fourth and fifth days, 100 mg 1 time/day. On the first day of the disease, it is possible to use the drug once at a dose of 300 mg.

Children aged 7 to 10 years are prescribed 50 mg 2 times a day; from 11 to 14 years - 50 mg 3 times / day. Over 14 years of age - adult doses.

Take within 5 days.

To prevent influenza, adults are prescribed 50 mg 1 time / day for up to 30 days. Children over 7 years old - 50 mg 1 time / day for up to 15 days.

Features of application:

Use for liver dysfunction. The use of the drug in patients with acute liver diseases is prohibited.

Use for renal dysfunction. The use of the drug in patients with acute and chronic kidney diseases is prohibited.

Use in children. The use of the drug in children under 7 years of age is prohibited.

Use in elderly patients. In elderly people, the drug can accumulate in toxic concentrations if the dose is not adjusted in proportion to the decrease in QC.

When using rimantadine, exacerbation of chronic concomitant diseases is possible. Elderly patients with arterial hypertension have an increased risk of developing hemorrhagic stroke.

If there is a history of epilepsy and ongoing anticonvulsant therapy while using rimantadine, the risk of developing an epileptic seizure increases. In such cases, rimantadine is used at a dose of 100 mg/day simultaneously with anticonvulsant therapy.

For influenza caused by virus B, rimantadine has an antitoxic effect.

Prophylactic administration is effective during contacts with sick people, during the spread of infection in closed groups and at a high risk of developing the disease during an influenza epidemic.

Viruses resistant to the drug may emerge.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Side effects:

From the digestive system: dry mouth, nausea, vomiting, loss of appetite, epigastric pain, flatulence.

From the central nervous system: headache, dizziness, insomnia, neurological reactions, impaired concentration, drowsiness, anxiety, increased excitability, fatigue.

Other: hyperbilirubinemia, allergic reactions (skin rash, itching, urticaria).

Interaction with other drugs:

Rimantadine reduces the effectiveness of antiepileptic drugs.

Paracetamol and ascorbic acid reduce the maximum concentration of rimantadine in blood plasma by 11%.

Cimetidine reduces the clearance of rimantadine by 18%.

Adsorbents, astringents and coating agents reduce the absorption of rimantadine.

Urine alkalizing agents (acetazolamide, sodium bicarbonate, etc.) increase the effectiveness of rimantadine due to a decrease in its excretion by the kidneys.

Contraindications:

- hypersensitivity to rimantadine;

— pregnancy and lactation;

- for lactase deficiency, lactose intolerance, lactose/isomaltose malabsorption syndrome (since the drug contains lactose).

With caution: with arterial hypertension, cerebral atherosclerosis, liver failure, epilepsy, gastrointestinal diseases.

Overdose:

Treatment: gastric lavage, symptomatic therapy: measures to maintain vital functions. Rimantadine is partially eliminated by hemodialysis

Storage conditions:

The drug should be stored in a dry place, protected from light and out of reach of children, at a temperature not exceeding 25 °C. Shelf life: 5 years.

Vacation conditions:

Package:

10 pieces. — contour cell packaging (2) — cardboard packs.

20 pcs. — cellular contour packages (1) — cardboard packs.

20 pcs. — polymer jars (1) — cardboard packs.

Published: July 14, 2015

Reviews of Rimantadine Avexima

Love January 30, 2017 at 07:24

I used it exactly according to the instructions. On the second day there was severe nausea, diarrhea and signs of hallucination.

Similar drugs

Antiviral (except HIV) drugs

Direct acting antiviral drugs.

Antiviral agents for systemic use.

Source: http://www.24farm.ru/preparats/rimantadin_aveksima/

Rimantadine Avexima

The information provided is intended for medical and pharmaceutical professionals, should not be used for treatment and cannot be considered as official. The most accurate information about the drug is contained in the instructions supplied with the packaging by the manufacturer. No information posted on this or any other page of our website can serve as a substitute for personal contact with a specialist.

Please pay attention to the specified dates for entering information; information may become outdated.

Source: http://www.webapteka.ru/drugbase/name52024.html

Rimantadine

Description current as of 07/11/2015

  • Latin name: Rimantadine
  • ATX code: J05AC02
  • Active ingredient: Rimantadine
  • Manufacturer: Irbit Chemical Pharmaceutical Plant, Moskhimfarmpreparaty im. N.A. Semashko, Biosynthesis OJSC, Moscow Endocrine Plant, Europharm, Tatkhimfarmpreparaty, Ozon LLC, PharmVILAR NPO (Russia), OLAINFARM (Latvia)

Compound

The tablet contains 50 mg of the active substance rimantadine hydrochloride.

The OLAINFARM company produces the medicine in the form of capsules, each of which contains 100 mg of the active substance rimantadine hydrochloride and auxiliary components: yellow dye called “sunset”, stearic acid, potato starch, lactose monohydrate. The film shell consists of 2 components: gelatin and titanium dioxide.

Release form

Rimantadine is available in the form of tablets and capsules.

The tablets are packaged in blisters of 10 pieces. The cardboard pack contains instructions from the manufacturer and 1-30 blisters. Additionally, the medicine is available in polymer jars of 20 pieces.

The capsules have a white gelatin shell. Inside each capsule there is an orange powder (deviations up to a brown or slightly pink tint are allowed) with isolated inclusions of white color. Capsules are packaged in special blisters. A cardboard pack contains 3 blisters, each containing 10 capsules.

pharmachologic effect

A medicine with antiviral activity. The active substance is made from amantadine. The antiviral effect is achieved due to the ability of the active component to inhibit the specific reproduction of the virus at an early stage immediately after its penetration into the cell.

Rimantadine interferes with the initial transcription of RNA. The pharmacological effect occurs when viral reproduction is inhibited at the earliest stages of the development of the infectious process.

The active substance exhibits antiviral activity against the causative agent of tick-borne encephalitis, influenza type A (especially A2).

Pharmacodynamics and pharmacokinetics

The active component is almost completely, although slowly absorbed from the lumen of the digestive tract. Rimantadine binds to plasma proteins by 40%. The Vd value in children is 289 l/kg, and in adults 17-25. In nasal secretions, the concentration of Rimantadine is 50% higher compared to plasma concentrations.

Metabolism occurs in the hepatic system. The half-life is hours. The drug is excreted by the renal system (20% - hydroxyl metabolites and 15% - unchanged). The half-life in patients suffering from chronic renal failure increases by 2 times.

It is possible that the drug may accumulate in the body to toxic concentrations in elderly people and in patients with pathologies of the renal system, which requires mandatory adjustment of the dosage regimen depending on the level of creatinine clearance.

Indications for use of Rimantadine

What is the medicine prescribed for?

The medication is prescribed for the prevention of tick-borne encephalitis (with viral etiology), for the treatment and prevention of influenza during an epidemic.

Contraindications

  • thyrotoxicosis;
  • pathology of the renal system (chronic course and acute forms);
  • diseases of the liver system (acute forms);
  • individual hypersensitivity;
  • pregnancy;
  • age limit – up to 7 years.

Side effects

Nervous system:

  • anxiety;
  • dizziness;
  • nervousness;
  • increased excitability;
  • headache;
  • sleep disorders (insomnia/drowsiness);
  • fatigue;
  • disturbances in concentration.

Digestive tract:

  • flatulence;
  • epigastric pain;
  • nausea;
  • increased concentration of bilirubin in the blood;
  • vomit;
  • anorexia;
  • gastralgia;
  • dry mouth.

In predisposed individuals, allergic responses are recorded, which requires discontinuation of the medication and the prescription of antihistamines (Xyzal, Cetrin, Suprastin).

Rimantadine tablets, instructions for use (Method and dosage)

The treatment regimen with 50 mg tablets is selected individually depending on the clinical picture, symptoms of the underlying disease, the patient’s age, and concomitant therapy.

Overdose

An increase in the severity of negative reactions described in the “Side Effects” section has been recorded.

Interaction

Ascorbic acid, ammonium chloride and other drugs that acidify urine increase the removal of Rimantadine from the blood, reducing its antiviral activity. The absorption of the active substance decreases with simultaneous therapy with enveloping, astringent and adsorbent agents. Acetylsalicylic acid and Paracetamol reduce the maximum concentration of the active substance by 11%.

Rimantadine Actitab can inhibit the activity of antiepileptic drugs. Sodium bicarbonate, acetazolamide and other agents that alkalize urine slow down the excretion of the active substance from the body, thereby increasing the activity of Rimantadine.

Cimetidine can reduce the clearance rate of the drug by 18%.

Terms of sale

Rimantadine tablets are sold in pharmacies. It is not necessary to present a prescription form from a doctor.

Storage conditions

Rimantadine 50 mg should be stored in a dry place. It is recommended to limit exposure to direct sunlight.

Best before date

special instructions

In some cases, exacerbations of previously diagnosed chronic diseases in patients have been reported. Elderly people suffering from hypertension have an increased likelihood of developing hemorrhagic stroke.

The likelihood of an epileptic seizure while taking Rimantadine increases significantly in people who have previously received anticonvulsant therapy and are registered with an epileptologist. This category of patients is recommended to take no more than 100 mg of Rimantadine per day.

For influenza type B, the active component exhibits an antitoxic effect. Taking medication for prophylactic purposes after contact with a sick person or after staying in closed groups helps prevent the transmission of a viral infection. It has been noted that viruses can develop resistance.

Analogs

  • Algirem;
  • Flumadin;
  • Remantadine;
  • Polyrem.

For children

Can be used in pediatric practice after reaching 7 years of age.

During pregnancy and lactation

Reviews of Rimantadine

On thematic forums, users talk about positive experiences with using the medication, especially emphasizing the effectiveness of the medication when used as a prophylaxis after contact with a patient or after being in a hotbed of a viral infection.

The drug is well tolerated, causing adverse reactions only in predisposed patients.

Rimantadine price, where to buy

The cost of the drug in Russia is rubles, depending on the number of tablets/capsules, pharmacy chain and region of sale.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Ukraine Ukraine
  • Online pharmacies in Kazakhstan Kazakhstan

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BIOSPHERE

Education: Graduated from the Bashkir State Medical University with a degree in General Medicine. In 2011, she received a diploma and certificate in Therapy. In 2012, she received 2 certificates and diplomas in “Functional Diagnostics” and “Cardiology”. In 2013, she took courses on “Current issues in otorhinolaryngology in therapy.” In 2014, she completed advanced training courses in the specialty “Clinical Echocardiography” and courses in the specialty “Medical Rehabilitation”.

Work experience: From 2011 to 2014, she worked as a therapist and cardiologist at the Municipal Budgetary Healthcare Institution Polyclinic No. 33 in Ufa. Since 2014, he has been working as a cardiologist and functional diagnostics doctor at the Municipal Budgetary Healthcare Institution Polyclinic No. 33 in Ufa.

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The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/rimantadin