Oxymetazoline overdose

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Oxymetazoline

Oxymetazoline instructions

Oxymetazoline is an alpha-adrenomimetic, anticongestive, vasoconstrictor drug for topical use. When administered intranasally, it causes a narrowing of small vessels (arterioles and venules) of the nasal mucosa, which reduces the local inflammatory process, hyperemia and swelling, resulting in easier nasal breathing in viral, bacterial and allergic rhinitis and sinusitis.

Table of contents:

Oxymetazoline has several forms of release in the form of an aerosol for intranasal use, containing 1 milliliter microgram of oxymetazoline hydrochloride in a bottle of 20 and 30 milliliters and in the form of intranasal drops with a concentration of 0.025% and 0.05% in bottles of 10 milliliters.

Indications for use of Oxymetazoline

This drug is widely used for the symptomatic treatment of acute inflammatory processes in the nasal cavity of allergic, bacterial or viral origin: rhinitis, otitis, eustachitis, sinusitis, hay fever and hay fever. This drug is also part of complex therapy for laryngitis and nasopharyngitis to relieve symptoms and reduce hyperemia, swelling and exudative processes of the nasal cavity and for swelling and congestion of the conjunctiva (used in the form of eye drops).

Directions for use and dosage of Oxymetazoline

Adult patients and children over seven years of age are prescribed Oxymetazoline in a solution of 0.05%, one to two drops intranasally two to three times a day or 0.05% nasal spray, one injection intranasally two to three times a day. Children aged from one to seven years are prescribed Oxymetazoline at a concentration of 0.025% intranasally, one to two drops two to three times a day for no more than 3 days.

Contraindications to the use of Oxymetazoline

The use of Oxymetazoline is contraindicated in case of hypersensitivity to the active active substance or auxiliary substances, atrophic rhinitis, hyperthyroidism, diabetes mellitus, angle-closure glaucoma, and during pregnancy and lactation. Also, Oxymetazoline is not prescribed for severe atherosclerosis, heart failure, arterial hypertension, arrhythmia and severe renal or liver failure.

Side effects of Oxymetazoline

With frequent and prolonged use of Oxymetazoline in high doses, side effects may occur - palpitations, headache, sneezing and burning and discomfort of the nasal mucosa, insomnia, increased excitability, dizziness, nausea.

Oxymetazoline overdose

Symptoms of overdose are nausea, constriction of the pupils, vomiting, cyanosis, tachycardia, increased body temperature, arrhythmia, increased blood pressure. With the simultaneous use of high doses of Oxymetazoline, mental disorders may occur, which are accompanied by drowsiness, and pathological conditions with bradycardia, severe arterial hypotension, and with the possible development of pulmonary edema, coma and cardiac and respiratory arrest.

Oxymetazoline for children

Oxymetazoline is a local anticongestive and vasoconstrictor drug for the treatment of acute and chronic allergic, bacterial and viral catal inflammatory processes of the nasal cavity: rhinitis and sinusitis, hay fever and hay fever. This drug is also part of complex therapy for otitis, eustachitis, laryngitis and nasopharyngitis to relieve the symptoms of the underlying disease to reduce swelling, hyperemia and exudative processes in the nasal cavity.

In adolescence and childhood (over seven years of age), Oxymetazoline is prescribed at a concentration of 0.05% in a dosage of one to two drops two to three times a day intranasally or 0.05% nasal spray, one injection into each nostril two to three times. per day. Children aged from one to seven years are prescribed Oxymetazoline at a concentration of 0.025% intranasally, one to two drops two to three times a day for no more than 3 days.

It is important for parents to remember that the use of this drug in childhood is necessary only as directed and under the dynamic supervision of the attending physician, observing the dosage and frequency of administration of nasal drops or spray. If therapeutic doses of Oxymetazoline are exceeded, side effects or symptoms of overdose may occur. If you experience burning and dryness of the nasal mucosa, sneezing, arrhythmia, nausea and vomiting. Symptoms of overdose are arterial hypotension, bradycardia, drowsiness, coma and respiratory and cardiac arrest.

If you experience symptoms of an overdose or side effects in connection with the use of Oxymetazoline drug, you should immediately stop taking this drug and seek medical help. In case of acute overdose symptoms, treatment is prescribed in a hospital setting - symptomatic pathogenetic therapy.

Oxymetazoline during pregnancy

The decongestant vasoconstrictor drug Oxymetazoline is contraindicated at any stage of pregnancy, which is associated with a possible risk of side effects in the mother and adverse effects on the fetus.

Oxymetazoline analogues

Analogs of Oxymetazoline are drugs - Nazivin (Germany), Fazin (USA), Nazol (USA), Fervex spray for the common cold (Canada), Oxymetazoline (Belarus).

Oxymetazoline prices

The cost of drugs with the active ingredient - Oxymetazoline: Nazivin in nasal drops - from 97 to 130 rubles, Nazol spray - 205 - 247 rubles, Vicks Active Sinex - 250 - 288 rubles, Oxymetazoline drops rubles.

Oxymetazoline reviews

Oxymetazoline is an effective anticongestive agent that causes constriction of small arterioles and venules of the mucous membranes of the nose, eustachian tube and paranasal sinuses, resulting in a long-term and gentle reduction in swelling and inflammation of the mucous membranes, which leads to easier breathing and the outflow of mucus during sinusitis.

Oxymetazoline nasal spray contains menthol, camphor and eucalyptol, which have additional local anti-inflammatory, anti-edematous and antiseptic effects, improve the outflow of mucus from the paranasal sinuses, diluting it, and help increase the duration of action of this drug.

This drug is widely used for the treatment of rhinitis of infectious and allergic origin, otitis, eustachitis and sinusitis. This drug is also used for symptomatic treatment of laryngitis and nasopharyngitis to reduce swelling, hyperemia and exudative processes in the nasal cavity and sinuses.

It is important to remember that the use of this drug is contraindicated in case of individual hypersensitivity to Oxymetazoline, atrophic rhinitis, hyperthyroidism, diabetes mellitus, pregnancy and lactation. Also, Oxymetazoline is not prescribed for severe atherosclerosis, arrhythmia, arterial hypertension and severe renal or liver failure.

Source: http://nasmork-rinit.com/meditsinskie-preparaty/232-oksimetazolin

Instructions for use of drugs, analogues, reviews

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Only the most current official instructions for the use of medicines! Instructions for medications on our website are published unchanged in the form in which they are attached to the medications.

Oxymetazoline*

PRESCRIPTION MEDICINES ARE PRESCRIBED TO THE PATIENT ONLY BY A DOCTOR. THIS INSTRUCTION IS FOR MEDICAL PROFESSIONALS ONLY.

Description of the active substance Oxymetazoline/Oxymetazolinum.

Formula: C16H24N2O, chemical name: 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol (as hydrochloride).

Pharmacological group: vegetotropic agents/adrenomimetic agents/alpha-adrenergic agonists; organotropic agents/respiratory agents/anticongestants.

Pharmacological action: vasoconstrictor, alpha-adrenomimetic, anticongestive.

Pharmacological properties

Oxymetazoline has a stimulating effect on alpha-adrenergic receptors (in low concentrations it acts on alpha2-adrenergic receptors, in high concentrations also on alpha1-adrenergic receptors). Oxymetazoline has a vasoconstrictor effect at the site of application. When used intranasally, oxymetazoline facilitates nasal breathing, reduces swelling of the mucous membrane of the upper respiratory tract, and reduces blood flow to the venous sinuses. Oxymetazoline, eliminating swelling of the nasal mucosa, helps restore the airiness of the paranasal sinuses and middle ear cavity, this prevents the development of bacterial complications (sinusitis, otitis media). When used intranasally in recommended doses, oxymetazoline does not irritate or cause hyperemia of the nasal mucosa. Reduces swelling of the conjunctiva when instilled into the conjunctival sac. The effect of oxymetazoline develops 15 minutes after instillation and lasts 6–8 hours. When used topically, oxymetazoline is absorbed to a small extent, so its content in the blood serum is insignificant. Oxymetazoline is excreted mainly unchanged in feces and urine; the half-life is 5–8 days.

Indications

Vasomotor rhinitis, acute rhinitis (including allergic), sinusitis, otitis media, eustachitis; restoration of drainage in case of eustachitis, inflammation of the paranasal sinuses, otitis media; acute respiratory diseases that are accompanied by a runny nose; for diagnostic purposes to narrow the vessels of the mucous membrane (under the supervision of a physician).

Method of administration of oxymetazoline and dose

Oxymetazoline is used intranasally: patients over 12 years old - 2 - 3 injections of 0.05% spray or 1 - 2 drops of 0.025 - 0.05% solution in each nasal passage 2 - 3 times a day; children 6 - 12 years old - one injection into each nostril; repeated administration is possible after 10–12 hours. The duration of the course of therapy should be no more than 3–5 days; Consultation with a doctor is necessary if further treatment is necessary.

In children, the absorption of oxymetazoline into the blood, leading to the development of systemic adverse reactions, may be increased.

When using drugs that contain oxymetazoline, a general effect on the nervous and cardiovascular systems is possible. In these cases, the ability to operate vehicles or equipment and perform activities that require increased attention and speed of psychomotor reactions may be reduced, so caution is required.

Contraindications for use

Hypersensitivity, including to other decongestants for intranasal use; closed-angle glaucoma, atrophic rhinitis, arterial hypertension, heart rhythm disturbances, severe atherosclerosis, chronic heart failure, angina pectoris, thyrotoxicosis, diabetes mellitus, age up to 6 years (for spray 0.05%), age up to 1 year (for drops 0.025 and 0 .05%).

Restrictions on use

Concomitant use of monoamine oxidase inhibitors and other drugs that increase blood pressure, as well as a period of up to 10 days after their use; increased intraocular pressure, pregnancy, lactation.

Use during pregnancy and breastfeeding

The use of oxymetazoline during breastfeeding and pregnancy is possible after careful assessment of the expected benefit to the mother and the possible risk to the child or fetus. Do not exceed the recommended dosage.

Side effects of oxymetazoline

Local reactions: burning sensation and dryness of the nasal mucosa, sneezing, dry mouth or throat, “rebound” swelling of the mucous membrane (nasal congestion or increased nasal discharge).

Systemic effects: agitation, insomnia, sleep disturbance, anxiety, increased anxiety, fatigue, headache, dizziness, nausea, palpitations, tachycardia, increased blood pressure.

Other (with prolonged use): recurrent swelling of the nasal mucosa, atrophy of the nasal mucosa and reactive hyperemia of the mucous membrane, tachyphylaxis.

Interaction of oxymetazoline with other substances

Oxymetazoline slows down the systemic absorption of local anesthetic drugs and prolongs their effect. Concomitant use of oxymetazoline with other vasoconstrictors increases the risk of adverse reactions. When oxymetazoline is used together with tricyclic antidepressants or monoamine oxidase inhibitors, an increase in blood pressure may occur. Oxymetazoline may temporarily reduce the absorption of levocabastine when administered intranasally. Acebutolol increases the possibility of developing a systemic hypertensive effect of oxymetazoline.

Overdose

In case of an overdose (or accidental ingestion) of oxymetazoline, nausea, constriction of the pupils, vomiting, increased body temperature, cyanosis, tachycardia, vascular insufficiency, arrhythmia, respiratory disorders, arterial hypertension, cardiac arrest, pulmonary edema develop; Mental disorders and depression of the central nervous system may also appear, which is accompanied by drowsiness, bradycardia, arterial hypotension, decreased body temperature, respiratory arrest, and coma. Necessary: ​​gastric lavage, intake of activated carbon, urgent hospitalization, symptomatic treatment.

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Oxymetazoline

Oxymetazoline: instructions for use and reviews

Latin name: Oxymetazoline

ATX code: S01GA04

Active ingredient: oxymetazoline (oxymetazoline)

Manufacturer: VIPS-MED, LLC (Russia), Nanjing Tianlang Pharmaceuticals Co., Ltd. (China), Pharmstandard-Leksredstva, OJSC (Russia), Pharmtechnology (Republic of Belarus)

Update of description and photo: 11/30/2017

Oxymetazoline is a drug used locally in ENT practice and has a vasoconstrictor effect; alpha adrenergic agonist.

Release form and composition

Dosage forms of Oxymetazoline:

  • nasal spray 0.05%: colorless transparent liquid [10, 15 or 20 ml each in a polyethylene bottle with a spray nozzle or spray pump with a protective cap (for 10 ml); 1 bottle in a cardboard box];
  • nasal drops 0.01%, 0.025% or 0.05%: slightly opalescent or transparent, colorless or pale yellow liquid (0.01% - 5 or 10 ml each, 0.025 and 0.05% - 5, 10, 15 or 20 ml in a polyethylene bottle with a hermetically sealed dropper stopper and a screw cap, 1 bottle in a cardboard box).

Composition of 1 ml spray:

  • active substance: oxymetazoline hydrochloride – 0.5 mg;
  • additional components: benzalkonium bromide, hydrochloric acid solution qs, sodium chloride, purified water.

Composition of 1 ml drops:

  • active substance: oxymetazoline hydrochloride – 0.1; 0.25 or 0.5 mg;
  • additional components: benzalkonium chloride, purified water, sodium hydroxide 0.1M; additionally, depending on the manufacturer - sodium phosphate monosubstituted, sodium chloride, sodium phosphate disubstituted, Trilon B or disodium edetate dihydrate, sodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate dihydrate.

Pharmacological properties

Pharmacodynamics

Oxymetazoline is a drug with vasoconstrictor (vasoconstrictor) and anticongestive effectiveness. When applied topically, the drug, stimulating alpha1-adrenergic receptors, leads to a narrowing of the vessels of the nasal mucosa, paranasal sinuses and eustachian tube, which eliminates their swelling. Thanks to the action of the drug, nasal breathing is facilitated against the background of allergic and infectious-inflammatory rhinitis, and blood flow to the venous sinuses is reduced. Oxymetazoline prevents the occurrence of bacterial complications such as sinusitis, sinusitis, and otitis media.

According to the results of clinical studies, the effect of the drug is observed within a few minutes after administration and lasts up to 12 hours.

Pharmacokinetics

When applied topically, oxymetazoline hydrochloride does not exhibit systemic effects. When administered intranasally, the half-life is 35 hours or more. Approximately 2.1% of the drug is excreted in urine, and 1.1% in feces.

Indications for use

  • acute respiratory diseases (ARI), accompanied by a runny nose (symptomatic therapy);
  • allergic rhinitis;
  • vasomotor rhinitis (for drops);
  • rhinitis of infectious-inflammatory nature (for spray);
  • otitis media;
  • eustachitis;
  • sinusitis;
  • hay fever.

According to the instructions, Oxymetazoline is also recommended for use to relieve swelling before rhinoscopy or other manipulations in the nasal passages.

Contraindications

  • angle-closure glaucoma;
  • atrophic rhinitis;
  • condition after transsphenoidal hypophysectomy;
  • history of surgical interventions on the dura mater;
  • age up to 1 year – for drops 0.025%;
  • age up to 6 years – for 0.05% drops and spray;
  • combined use with monoamine oxidase inhibitors (MAOIs), as well as a two-week period before and after completion of therapy with the latter;
  • pregnancy - for drops, depending on the manufacturer;
  • hypersensitivity to any of the components of the drug.

Relative (oxymetazoline is prescribed with extreme caution):

  • diseases of the cardiovascular system: arterial hypertension, arrhythmias, chronic heart failure, tachycardia, lesions of the coronary arteries, severe atherosclerosis;
  • chronic renal failure;
  • increased intraocular pressure;
  • diabetes;
  • hyperthyroidism;
  • pheochromocytoma;
  • porphyria;
  • prostatic hyperplasia (urinary retention);
  • pregnancy and breastfeeding;
  • combined use with tricyclic antidepressants, bromocriptine and other drugs that lead to an increase in blood pressure (BP).

Instructions for use of Oxymetazoline: method and dosage

Oxymetazoline is administered intranasally.

Nasal spray

Before each administration of the spray, the bottle must be shaken vigorously.

For children over 6 years of age and adults, it is recommended to apply 1 injection into each nasal passage at intervals of 10–12 hours. If the therapeutic effect is insufficient in adults, the frequency of use can be increased to 3 times a day. The indicated dose should not be exceeded.

Before using the bottle for the first time, it is necessary to calibrate it by pressing the head of the nozzle or spray pump several times.

If you need to take a course longer than 5 days, you should consult your doctor.

Nasal drops

Recommended single doses and frequency of administration (per day), taking into account the patient’s age and dosage of the drug:

  • children under 1 year: 0.01% solution - from birth to the 5th week of life, prescribed 2-3 times or 1 time (depending on the manufacturer), 1 drop in each nasal passage; from the 5th week to 1 year - 2-3 times, 1-2 drops in each nasal passage;
  • children from 1 year to 6 years: 0.025% solution - 2-3 times, 1-2 drops in each nasal passage;
  • children over 6 years old and adults: 0.05% solution - 2-3 times, 1-2 drops in each nasal passage.

Oxymetazoline drops should not be used for more than 7 days.

Side effects

  • cardiovascular system: uncommon – increased blood pressure, palpitations, tachycardia; extremely rarely - arrhythmia;
  • nervous system: rarely - headache, anxiety, fatigue (loss of energy, drowsiness), insomnia, hallucinations;
  • respiratory system: often – burning/dryness of the nasal mucosa (transient), hypersecretion, sneezing, for spray – dry mouth and throat; uncommon – reactive hyperemia (increased swelling of the nasal mucosa), nosebleeds.

Adverse reactions caused by the systemic effect of oxymetazoline may include dizziness, sleep disturbances (in children), increased anxiety, irritability, itching, Quincke's edema, exanthema, nausea, blurred vision (if in contact with the eyes), respiratory arrest (in infants), convulsions.

Against the background of long-term and continuous treatment with vasoconstrictor drugs, drug-induced rhinitis (recurrent swelling of the nasal mucosa), tachyphylaxis, and atrophy of the nasal mucosa may occur.

Overdose

Symptoms of overdose may include fever, vomiting, nausea, cyanosis, dilated pupils, mental disorders, shortness of breath, arterial hypertension, arrhythmia, tachycardia, cardiac arrest, pulmonary edema, depression of the central nervous system (decreased blood pressure, decreased body temperature, drowsiness, bradycardia, arrest breathing and coma).

Treatment in case of overdose is recommended to be symptomatic. In case of accidental oral administration of the drug, gastric lavage and activated charcoal are prescribed to evacuate the contents of the gastrointestinal tract; these measures should be carried out immediately since oxymetazoline is rapidly absorbed. If blood pressure decreases, selective alpha-blockers cannot be used. If necessary, anticonvulsants and antipyretics are administered and artificial ventilation is prescribed. Vasopressor drugs are contraindicated for use.

special instructions

You must be careful not to get Oxymetazoline into your eyes.

Continuous therapy with the drug should not be carried out for more than 7 days.

In case of prolonged or frequent use of the drug, symptoms of nasal congestion may recur or worsen. If this effect occurs, you must stop treatment and consult a specialist.

The nasal drops contain benzalkonium chloride, which can cause swelling and irritation of the nasal mucosa.

Impact on the ability to drive vehicles and complex mechanisms

When using Oxymetazoline spray and drops in therapeutic doses, no negative effect on the ability to drive vehicles or operate complex machinery was noted. However, with a long course of treatment using high doses, the possibility of developing systemic adverse reactions of the drug cannot be excluded. In this case, it is necessary to exercise caution when performing work that requires special concentration and quick reactions.

Use during pregnancy and lactation

There are no clinical data confirming the safety of using the drug during pregnancy and lactation. As a result, Oxymetazoline should only be used in pregnant or breastfeeding women in extreme cases, when, in the opinion of the attending physician, the expected benefit of drug therapy for the mother significantly outweighs the possible risk to the fetus/child.

Use in childhood

Children under 6 years of age are contraindicated to use spray and drops of 0.05%, children under 1 year of age - drops of 0.025%.

For impaired renal function

In the presence of chronic renal failure, it is recommended to use Oxymetazoline with extreme caution.

Drug interactions

  • local anesthetic drugs: their absorption slows down and the effect is prolonged;
  • MAO inhibitors (including 14 days before and after their use), other drugs that cause an increase in blood pressure: the risk of arterial hypertension is aggravated;
  • tricyclic antidepressants: the risk of arrhythmia and hypertension increases;
  • other vasoconstrictor drugs: the likelihood of adverse reactions increases.

Analogs

Analogues of Oxymetazoline are Afrin, Nazivin, Afrin extro, Nazol Advance, Nazivin Sensitive, Nazo-spray, Vicks Active Sinex, Nazol, Nesopin, Otrivin, Noxprey, Rinostop Extra, Oxyfrin, Sialor.

Terms and conditions of storage

Store at a temperature of 0–25 °C, in a place protected from light, out of reach of children.

The shelf life of the spray is 3 years, drops – 2 years.

Conditions for dispensing from pharmacies

Available without a prescription.

Reviews about Oxymetazoline

According to most reviews, Oxymetazoline is an effective and inexpensive drug that helps adults and children quickly eliminate nasal congestion and reduce swelling of the nasal mucosa. Patients confirm that nasal breathing is restored within 5–10 minutes after administration of drops or spray, and this effect lasts up to 10–12 hours.

The disadvantages of Oxymetazoline include adverse reactions, the most common of which are transient dryness and burning that occur after its administration.

Price for Oxymetazoline in pharmacies

There is no reliable data on the price of Oxymetazoline, since the drug is currently not on sale.

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Oxymetazoline

Content

Structural formula

Russian name

Latin name of the substance Oxymetazoline

Chemical name

3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol (as hydrochloride)

Gross formula

Pharmacological group of the substance Oxymetazoline

Nosological classification (ICD-10)

CAS code

Characteristics of the substance Oxymetazoline

Oxymetazoline hydrochloride is easily soluble in water and alcohol. Practically insoluble in ether, chloroform, benzene. Molecular weight 296.84.

Pharmacology

Stimulates alpha-adrenergic receptors: in low concentrations it mainly has an α 2 -adrenomimetic effect, in high concentrations it also acts on α 1 -adrenergic receptors. Constricts blood vessels at the site of application. When administered intranasally, it reduces swelling of the mucous membrane of the upper respiratory tract, facilitates nasal breathing, and reduces blood flow to the venous sinuses. When instilled into the conjunctival sac, it reduces swelling of the conjunctiva. The action begins 15 minutes after application, duration is 6–8 hours.

When applied topically (spray), oxymetazoline undergoes systemic absorption to a small extent, so its concentration in the blood plasma is insignificant. It is excreted mainly unchanged in urine and feces. T 1/2 is 5–8 days.

Use of the substance Oxymetazoline

Acute rhinitis (including allergic), vasomotor rhinitis, paranasal sinusitis, eustachitis, otitis media; to narrow the vessels of the mucous membrane for diagnostic purposes (under medical supervision).

Contraindications

Hypersensitivity, incl. to other decongestants for intranasal use; atrophic rhinitis, angle-closure glaucoma, arterial hypertension, severe atherosclerosis, heart rhythm disturbances, chronic heart failure, diabetes mellitus, thyrotoxicosis, children under 1 year of age (for drops 0, 025 and 0.05%), children under 6 years of age (for spray 0.05%).

Use during pregnancy and breastfeeding

During pregnancy and breastfeeding, the recommended dosage should not be exceeded. Use is possible after a careful assessment of the balance of benefit to the mother and risk to the fetus or child.

Side effects of the substance Oxymetazoline

Local reactions: dryness and burning sensation of the nasal mucosa, dry mouth or throat, sneezing, “ricochet” swelling of the mucous membrane (increased nasal discharge or nasal congestion).

Systemic effects: sleep disturbance, agitation, increased anxiety, dizziness, headache, palpitations, nausea, increased blood pressure.

Other: tachyphylaxis, reactive hyperemia of the mucous membrane and atrophy of the nasal mucosa (with long-term use).

Interaction

Slows down the systemic absorption of local anesthetics and prolongs their effect. Combined use with other vasoconstrictor drugs increases the risk of side effects. With the simultaneous use of oxymetazoline and MAO inhibitors or tricyclic antidepressants, an increase in blood pressure is possible.

Overdose

Symptoms (after a significant overdose or accidental ingestion): constriction of the pupils, nausea, vomiting, cyanosis, increased body temperature, tachycardia, arrhythmia, vascular insufficiency, arterial hypertension, respiratory disorders, pulmonary edema, cardiac arrest; in addition, mental disorders may appear, as well as depression of central nervous system functions, accompanied by drowsiness, decreased body temperature, bradycardia, arterial hypotension, respiratory arrest and the possible development of coma.

Treatment: gastric lavage, taking activated carbon, urgently consulting a doctor, symptomatic therapy.

Precautions for the substance Oxymetazoline

In children, the absorption of oxymetazoline into the blood may be increased, leading to the development of side effects.

After long-term use of cold remedies containing oxymetazoline in dosages higher than recommended, a general effect on the cardiovascular system and the central nervous system cannot be ruled out. In these cases, the ability to operate a vehicle or equipment may be impaired.

Interactions with other active ingredients

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Oxymetazoline

Description current as of 03/07/2015

  • Latin name: Oxymetazoline
  • ATX code: S01GA04
  • Active ingredient: Oxymetazoline (Oxymetazoline)
  • Manufacturer: UPDATE (Russia), PHARMSTANDARD-LEKSREDSTVA (Russia), Pharmtechnology (Belarus)

Compound

One milliliter of Oxymetazoline nasal drops contains 500, 100 or 250 mcg of oxymetazoline hydrochloride.

One milliliter of Oxymetazoline spray contains 500 mcg of oxymetazoline hydrochloride.

Additional substances: 12-water disodium phosphate, sodium hydroxide solution, disodium edetate, dihydrate sodium phosphate, benzalkonium chloride, water.

Release form

Nasal drops are a colorless transparent liquid.

  • 2 ml of liquid in a dropper tube; one, five or twenty dropper tubes in a cardboard pack.
  • 10 ml of liquid in a dropper tube; one, five or twenty dropper tubes in a cardboard pack.
  • 15 ml of liquid in a dropper tube; one, five or twenty dropper tubes in a cardboard pack.
  • 20 ml of liquid in a dropper tube; one, five or twenty dropper tubes in a cardboard pack.

The nasal spray is a colorless, clear liquid.

  • 15, 10 or 20 ml of liquid in a polyethylene bottle with a spray nozzle; one bottle in a cardboard pack.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

Adrenomimetic type agent for local use. Has a vasoconstrictor effect. When administered intranasally, swelling of the mucous membranes of the respiratory tract is reduced. When administered into the conjunctival sac, it reduces swelling of the conjunctiva.

The effect appears a quarter of an hour after application and lasts for 7-8 hours.

Indications for use

  • Swelling of the conjunctiva.
  • Rhinitis with colds, eustachitis, inflammation of the sinuses, allergic diseases, hay fever.

Contraindications

Side effects

  • Reactions from breathing: temporary burning and dryness of the nasal mucosa, sneezing, dry mouth, reactive hyperemia or atrophy of the mucous membranes.
  • Reactions from the blood circulation: increased heart rate, arterial hypertension.
  • Reactions from the nervous system: excitability, dizziness, tachyphylaxis, headache, sleep disturbances.
  • Digestive reactions: nausea.
  • Reactions from the visual side: with the conjunctival route of administration, the development of mydriasis, irritation of the conjunctiva, accommodation paresis, and eyelid retraction is possible.

Instructions for use of Oxymetazoline (Method and dosage)

Children over 6 years old and adults are recommended to instill 1-2 drops of the drug into both nostrils up to two times a day.

For congestive processes and swelling of the conjunctiva, use 1-2 drops of the product in each eye.

At the recommended dosage, Oxymetazoline can be used alone for up to three days. If no visible improvement is observed within the specified period of time, you should consult a doctor.

Overdose

When used topically, an overdose is unlikely.

Interaction

Oxymetazoline inhibits the absorption of local anesthetics and prolongs their duration of action.

When co-administered with tricyclic antidepressants and MAO inhibitors, blood pressure may increase.

The simultaneous administration of other vasoconstrictor drugs increases the likelihood of developing undesirable effects.

Terms of sale

Storage conditions

Store at room temperature. Keep away from children.

Best before date

special instructions

It is advised to avoid contact of the product intended for nasal use with the eyes.

In recommended dosages, Oxymetazoline can be used for up to 3 days without consulting a doctor.

The drug affects vision, and the reaction may also slow down, which must be taken into account when driving.

Analogs

For children

Children 1-7 years old are recommended to instill 1-2 drops of a 0.025% solution into both nostrils twice a day. In children over 7 years of age, adult dosages of the drug are used.

During pregnancy and lactation

The drug is not intended for use during the specified periods.

Reviews

According to patients, Oxymetazoline effectively relieves swelling and restores breathing through the nose for up to 8 hours. There are almost no cases of side effects.

Oxymetazoline price, where to buy

The price of Oxymetazoline in drops 0.01% 10 ml in Russia starts from 40 rubles.

Education: Graduated from Vitebsk State Medical University with a degree in Surgery. At the university he headed the Council of the Student Scientific Society. Advanced training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".

Work experience: Worked in a general medical network for 3 years as a surgeon (Vitebsk Emergency Hospital, Liozno Central District Hospital) and part-time as a district oncologist and traumatologist. Worked as a pharmaceutical representative for a year at the Rubicon company.

Presented 3 rationalization proposals on the topic “Optimization of antibiotic therapy depending on the species composition of microflora”, 2 works took prizes in the republican competition-review of student scientific works (categories 1 and 3).

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kotmatroskin: I got rid of prostatitis six months ago, was treated with many drugs, including red.

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Source: http://medside.ru/oksimetazolin

Oxymetazoline

  • Oxymetazoline

pharmachologic effect

Indications for use

Difficulty in nasal breathing due to colds, inflammation of the sinuses, eustachitis, hay fever, allergic rhinitis, congestion and swelling of the conjunctiva.

Mode of application

Side effects

From the respiratory system: possible transient dryness and burning of the mucous membrane of the nasal passages, dry mouth and throat, sneezing; with long-term use, reactive hyperemia of the mucous membrane and atrophy of the mucous membrane may occur.

From the cardiovascular system: palpitations; rarely - arterial hypertension.

From the side of the central nervous system: increased excitability, dizziness, headache, sleep disturbances; with long-term use - tachyphylaxis.

From the digestive system: nausea.

On the part of the organ of vision: with conjunctival administration, mydriasis, accommodation paresis, irritation of the conjunctiva and surrounding tissues, and eyelid retraction are possible.

Contraindications

Release form

Storage

Overdose

Inflammation of the mucous membrane of the nasal passages without secretion, chronic heart failure, hyperthyroidism, diabetes mellitus, pregnancy, children under 6 years of age (for eye drops), increased sensitivity to oxymetazoline, atrophic rhinitis, lactation, arrhythmias, severe atherosclerosis, arterial hypertension, chronic renal failure , angle-closure glaucoma.

Use in old age

Inflammation of the mucous membrane of the nasal passages without secretion, chronic heart failure, hyperthyroidism, diabetes mellitus, pregnancy, children under 6 years of age (for eye drops), increased sensitivity to oxymetazoline, atrophic rhinitis, lactation, arrhythmias, severe atherosclerosis, arterial hypertension, chronic renal failure , angle-closure glaucoma.

Drug interactions

With the simultaneous administration of MAO inhibitors and tricyclic antidepressants, an increase in blood pressure is possible.

Oxymetazoline slows down the absorption of local anesthetic drugs and prolongs their effect.

Co-administration of other vasoconstrictor drugs increases the risk of side effects.

Use in childhood

Contraindicated in children under 6 years of age (for eye drops).

Dosage

Ozdorovach is a medical portal. (c)17

Source: http://ozdorovach.ru/medicaments/oxymetazoline.html

Oxymetazoline

Oxymetazoline (novolat. Oxymetazolinum) is a vasoconstrictor drug for topical use, used as a component of cold remedies.

Content

Pharmacological action [edit]

Adrenomimetic agent for local use. Has a vasoconstrictor effect. When administered intranasally (into the nasal cavity), it reduces swelling of the mucous membrane of the upper respiratory tract. When instilled into the conjunctival sac (the cavity between the back surface of the eyelids and the front surface of the eyeball), it reduces swelling of the conjunctiva (outer shell of the eye). The effect of the drug appears 15 minutes after use and lasts 6-8 hours.

Indications for use [edit]

Difficulty in nasal breathing due to colds, inflammation of the nasal sinuses, eustachitis (inflammation of the mucous membrane of the auditory tube), hay fever, allergic rhinitis (runny nose of an allergic nature). Congestion and swelling of the conjunctiva.

Contraindications [edit]

With caution[edit]

Directions for use and dosage[edit]

Adults and school-age children are prescribed 1-2 drops of 0.05% of the drug in each nostril 2 times a day. Children aged 1 to 7 years are prescribed 1-2 drops of a 0.025% solution in each nostril 2 times a day. For congestion and swelling of the conjunctiva, instill 1-2 drops into each eye. The drug can be used on its own at the recommended dosage for no more than 3 days. If there is no improvement within this period of time, you should consult a doctor.

Side effects[edit]

Transient dryness and burning of the nasal mucosa, dry mouth and throat, sneezing. Rarely - hypertension (increased blood pressure), increased excitability, nausea, dizziness, sleep disturbance, palpitations. With prolonged use of the drug, reactive hyperemia (redness) of the mucous membrane may occur.

Overdose[edit]

Symptoms (after significant overdose or accidental ingestion)[edit]

Constriction of the pupils, nausea, vomiting, cyanosis, increased body temperature, tachycardia, arrhythmia, vascular insufficiency, arterial hypertension, respiratory disorders, pulmonary edema, cardiac arrest; in addition, mental disorders may appear, as well as depression of the functions of the central nervous system, accompanied by drowsiness, decreased body temperature, bradycardia, arterial hypotension, respiratory arrest and the possible development of coma.

Long-term use causes nasal congestion (tachyphylaxis). If it is impossible to take the drug in a timely manner, withdrawal syndrome develops, expressed in the complete impossibility of nasal breathing.

Treatment[edit]

Precautions[edit]

After prolonged use or use of cold remedies containing oxymetazoline in dosages exceeding the recommended ones, a general effect on the cardiovascular system and the central nervous system cannot be excluded. In these cases, the ability to operate a vehicle or equipment may be impaired.

Interaction[edit]

Slows down the absorption of local anesthetic drugs and prolongs their effect. Co-administration of other vasoconstrictor drugs increases the risk of side effects. With the simultaneous administration of MAO inhibitors (including the period within 14 days after their discontinuation) and tricyclic antidepressants - an increase in blood pressure.

Special instructions [edit]

Long-term use of decongestants for nasal instillation may lead to a weakening of their effect. Abuse of these drugs can cause mucosal atrophy and reactive hyperemia with rhinitis medicamentosa, as well as damage to the mucosal epithelium and inhibition of epithelial activity. Long-term use and overdose should be avoided.

Release form [edit]

Spray for intranasal (nasal) use in bottles of 20 and 30 ml. 1 ml - 500 mcg of oxymetazoline hydrochloride.

Eye drops in a bottle of 10 ml. 1 ml - 250 mcg of oxymetazoline hydrochloride.

Nasal drops in 10 ml bottles (1 ml - 250 and 500 mcg of oxymetazoline hydrochloride). Nasal drops in a dropper bottle of 10 ml (1 ml - 250 and 500 mcg of oxymetazoline hydrochloride). Nasal drops in a dropper bottle of 5 ml (1 ml - 100 mcg of oxymetazoline hydrochloride).

Storage conditions [edit]

List B. In a cool, dark place.

Source: http://wp.wiki-wiki.ru/wp/index.php/%D0%9E%D0%BA%D1%81%D0%B8%D0%BC%D0%B5%D1%82%D0 %B0%D0%B7%D0%BE%D0%BB%D0%B8%D0%BD

Oxymetazoline: instructions for use, dosage, contraindications, analogs and synonyms

Oxymetazoline is used to treat a runny nose during a cold. Its active components help to avoid the development of complications and quickly get rid of nasal congestion. It is guided by this principle that patients purchase this drug.

Packaging, release form, composition

The drug Oxymetazoline belongs to the category of vasoconstrictor nasal drops for topical use. The drug has a mild effect and is not absorbed into the blood. The active substance is oxymetazoline hydrochloride. 1 ml of the product contains 500 mcg. Also includes:

  • Water
  • Benzalkonium chloride
  • Monosodium phosphate dihydrate
  • Sodium hydroxide
  • Edetate Danodium
  • Sodium phosphate twelvehydrate

The medicine is available in the form of transparent colorless drops of 2, 10, 15 or 20 ml of liquid in a dropper tube of 1, 5 or 20 pieces in one cardboard package. Another form of release is a nasal spray, which also has no color.

Company manufacturer

Russian company Pharmtechnology.

Application of drops with oxymetazoline:

Purpose

The main purpose of Oxymetazoline drops is to treat runny nose in adults and children. Under the supervision of a doctor, it is prescribed for:

Possible contraindications

  • Atrophic form of rhinitis
  • Angle-closure glaucoma
  • Hypertension
  • Diabetes
  • Chronic heart failure
  • Thyrotoxicosis
  • Inflammation of the nose without mucus discharge
  • Chronic renal failure
  • Hyperthyroidism
  • Pregnancy
  • Lactation
  • Atherosclerosis
  • Arrhythmia

The drug Oxymetazoline is contraindicated for children under one year of age; a 0.05% solution is contraindicated for children under 6 years of age. Do not use if you are intolerant to any component of the composition.

Principle of operation

Oxymetazoline is applied topically. The drug has a vasoconstrictor effect, facilitates nasal breathing and reduces swelling of the mucous membrane. When it comes into contact with the inflamed conjunctiva, it removes swelling.

The duration of action of the drug lasts up to 8 hours. The first improvements in well-being are noted 15 minutes after application to the site. The drug is excreted through urine and feces within 5-8 days.

How to use Oxymetazoline?

  1. Children: 0.025% solution aged 1 to 6 years - 2 times within 24 hours, 1 drop.
  2. Children: 0.05% solution from the age of 7 years – 2 drops per 24 hours.
  3. Adults: 0.05% solution – 2 drops 2 times within 24 hours.

For swelling of the conjunctiva, 1-2 drops of Oxymetazoline are prescribed.

How to use vasoconstrictor drops correctly, watch our video:

Adverse reactions

  1. Dryness and burning in the nasal cavity
  2. Sneezing
  3. Dry mouth
  4. Mucosal atrophy
  5. Cardiopalmus
  6. Dizziness and headache
  7. Nausea
  8. Irritation of the conjunctiva
  9. Eyelid retraction

Overdose

An overdose is unlikely, since the drug is administered in doses using a special nozzle or sprayer.

Features of application

In children, the absorption of Oxymetazoline into the blood is higher, so side effects may occur after using the drops.

Exceeding the dosage prescribed by the instructions or a long course of treatment (more than 5 days) has an effect on the cardiovascular and central nervous systems. In this case, there may be a decrease in concentration and the ability to control complex mechanisms, including cars. Oxymetazoline affects the clarity of vision and may cause slower reactions.

In case of an overdose of the drug, you should perform a gastric lavage, drink a dose of activated carbon in accordance with your weight and consult a doctor.

Interaction with other drugs

Oxymetazoline prolongs the action, but inhibits the absorption of local anesthetics.

When taken simultaneously with tricyclic antidepressants, the risk of increased blood pressure increases.

When taking vasoconstrictor drugs simultaneously, the risk of adverse reactions increases.

Reviews

Oxymetazoline has received good reviews from patients, as it allows for easier nasal breathing in a short period of time. Adverse reactions occur infrequently. The medicine is well tolerated by all age groups and has an affordable price.

Price

The medicine in a volume of 10 ml and 0.01% concentration can be purchased from 40 rubles.

Analogs

  • Nazospray
  • Fervex spray
  • Nesopin
  • Sialor Reno
  • Oxyfin
  • Knoxprey
  • Advance
  • Sanorinchik
  • Fazin
  • Xylometazoline

Synonyms

  1. Nazivin
  2. Nazol
  3. 4-Wei
  4. Afrin
  5. Leconil R

How is it released from pharmacies?

When purchasing a medicine in the form of drops or spray, a prescription is not required.

How to treat a runny nose without depending on drops:

Storage conditions

Oxymetazoline should be stored in a cool place away from sunlight. Avoid getting the medicine into the hands of children. Temperature – no higher than room temperature.

The shelf life of the product is 3 years. After its expiration, the use of the drug is contraindicated.

Source: http://gidmed.com/otorinolarintologija/lekarstva-lor/oksimetazolin.html