Oxymetazoline nasal drops

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Nasal drops with oxymetazoline: application

Oxymetazoline is a drug belonging to the pharmacological group of alpha-adrenergic agonists, which improves nasal breathing due to anti-inflammatory, anti-congestive and vasoconstrictive effects.

Table of contents:

Dosage and release form

The active ingredient of this drug is oxymetazoline hydrochloride. Release forms:

  1. Nasal drops – bottle of 10 ml, 15 ml, 20 ml.
  2. Spray for intranasal use, 20 ml and 30 ml.
  3. Eye drops – 10 ml.

1 ml of the drug contains 100/250/500 mcg of the active component - oxymetazoline hydrochloride.

Pharmacodynamics

The action of Oxymetazoline is due to its effect on adrenergic receptors by stimulating them. The main target is adfa2 receptors. Thus, the expected therapeutic effect is achieved - relieving swelling at the injection site, reducing hyperemia and the area of ​​the inflammatory area, improving the outflow of venous blood through the venules. The action begins within 10–15 minutes after irrigation of the mucous membrane, and lasts from 6 to 8 hours. During this time, mucus production decreases and the nasal passages dry out. If Oxymetazoline spray or eye drops are used for a long time, systemic manifestations are possible due to good absorption through the mucous membranes. The conjunctival sac, through the nasolacrimal duct, communicates with the lower nasal passage in its anterior section.

Oxymetazoline-based eye and nasal drops should be used with caution to avoid overdose.

Indications

Oxymetazoline drops and spray are prescribed during the period of inflammatory and allergic processes in the nasal cavity, as well as for diagnostic purposes. Can be used for any age group in the absence of contraindications. Indications:

  • Colds accompanied by rhinitis - ARVI, influenza.
  • Inflammation of the sinuses.
  • Inflammation of the mucous membrane of the auditory tube.
  • In complex therapy to reduce catarrhal symptoms in pharyngitis, laryngitis.
  • Allergic manifestations, hay fever.
  • Conjunctival edema.
  • When examining the passages and cavities of the nose - rhinoscopy.

A wide range of nosological units is due to the rapid impact of droplets on cells and intercellular space.

Application

For adults: according to the instructions for use, Oxymetazoline is administered 1-2 drops/injection into each nostril, no more than 3 times a day. Ophthalmic forms - 1-2 drops in both eyes. Frequency of use – 2–3 times/day.

For children: intended for 0.01% (from 1 year to 5 years) or 0.025% (from 6 to 12 years) solution, 1-2 drops, up to 2 times a day, depending on age and disease. Children's Oxymetazoline in drop form is preferable. This is due to the anatomical structure of the facial part of the skull - the passages are short and wide, and it is possible for the medicine to enter the auditory tube when administered quickly or injected under pressure.

In pharmacy chains, the drug Oxymetazoline is available without a prescription, but it should be remembered that self-medication can be harmful to health.

The duration of the course for adults should not exceed 5–7 days, for children – 3–5 days. Treatment of newborns and infants (up to one year) should be strictly prescribed by a pediatrician after a thorough examination.

Side effects

Oxymetazoline preparations with frequent uncontrolled use can cause side effects, most often they are predetermined by their systemic action.

Not desired effects:

  • Excessive dryness, discomfort and burning sensation in the nose.
  • Sneezing.
  • Accommodation paresis, pupil dilation – mydriasis.
  • Increased heart rate.
  • Dizziness, headaches, sleep disturbances.
  • Hypertension, arrhythmias.
  • Rebound symptom: hyperemia of the mucous membrane.

Uncontrolled use of a vasoconstrictor drug can provoke the development of atrophic changes in the cells lining the nasal cavity. This is how an addiction to nasal drops with oxymetazoline occurs, the patient uses them more and more often, thereby aggravating the situation.

If eye forms are used, you should be careful while driving - the reaction of the nervous system may be slowed down.

Contraindications

It is recommended to use oxymetazoline-based drugs only for medical indications. According to the instructions, it is not permissible to use it in a group of people suffering from the following diseases:

  • Individual intolerance to one of the components.
  • Atrophy of the nasal mucosa.
  • Increased blood pressure and heart rate.
  • Glaucoma.
  • Renal dysfunction.
  • Severe atherosclerotic vascular lesions.
  • Arrhythmias.
  • Hyperthyroidism, history of thyrotoxic crises, diabetes mellitus.

The use of Oxymetazoline spray and drops during pregnancy should be agreed with a gynecologist to assess the benefit-harm ratio for the mother and child. It should be remembered that the active substance can be absorbed into the systemic bloodstream and cause a narrowing of the blood vessels supplying the fetus. Cases of placental insufficiency with the development of hypoxia cannot be excluded.

Interaction

Oxymetazoline, according to the instructions, is able to potentiate the effect of other vasoconstrictors. When used together with monoamine oxidase inhibitors or tricyclic antidepressants, the systemic effect on organs and tissues is enhanced. Slows down the absorption of local anesthetics, but prolongs their effect.

Analogs

There are many drugs on the pharmacological market that are similar in their action to Oxymetazoline. Analogues can be:

When choosing an alternative to Oxymetazoline spray or drops, it is advisable to consult a specialized doctor.

Source: http://elaxsir.ru/lekarstva/dlya-nosa/oksimetazolin-instrukciya-po-primeneniyu.html

Oxymetazoline

Oxymetazoline: instructions for use and reviews

Latin name: Oxymetazoline

ATX code: S01GA04

Active ingredient: oxymetazoline (oxymetazoline)

Manufacturer: VIPS-MED, LLC (Russia), Nanjing Tianlang Pharmaceuticals Co., Ltd. (China), Pharmstandard-Leksredstva, OJSC (Russia), Pharmtechnology (Republic of Belarus)

Update of description and photo: 11/30/2017

Oxymetazoline is a drug used locally in ENT practice and has a vasoconstrictor effect; alpha adrenergic agonist.

Release form and composition

Dosage forms of Oxymetazoline:

  • nasal spray 0.05%: colorless transparent liquid [10, 15 or 20 ml each in a polyethylene bottle with a spray nozzle or spray pump with a protective cap (for 10 ml); 1 bottle in a cardboard box];
  • nasal drops 0.01%, 0.025% or 0.05%: slightly opalescent or transparent, colorless or pale yellow liquid (0.01% - 5 or 10 ml each, 0.025 and 0.05% - 5, 10, 15 or 20 ml in a polyethylene bottle with a hermetically sealed dropper stopper and a screw cap, 1 bottle in a cardboard box).

Composition of 1 ml spray:

  • active substance: oxymetazoline hydrochloride – 0.5 mg;
  • additional components: benzalkonium bromide, hydrochloric acid solution qs, sodium chloride, purified water.

Composition of 1 ml drops:

  • active substance: oxymetazoline hydrochloride – 0.1; 0.25 or 0.5 mg;
  • additional components: benzalkonium chloride, purified water, sodium hydroxide 0.1M; additionally, depending on the manufacturer - sodium phosphate monosubstituted, sodium chloride, sodium phosphate disubstituted, Trilon B or disodium edetate dihydrate, sodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate dihydrate.

Pharmacological properties

Pharmacodynamics

Oxymetazoline is a drug with vasoconstrictor (vasoconstrictor) and anticongestive effectiveness. When applied topically, the drug, stimulating alpha1-adrenergic receptors, leads to a narrowing of the vessels of the nasal mucosa, paranasal sinuses and eustachian tube, which eliminates their swelling. Thanks to the action of the drug, nasal breathing is facilitated against the background of allergic and infectious-inflammatory rhinitis, and blood flow to the venous sinuses is reduced. Oxymetazoline prevents the occurrence of bacterial complications such as sinusitis, sinusitis, and otitis media.

According to the results of clinical studies, the effect of the drug is observed within a few minutes after administration and lasts up to 12 hours.

Pharmacokinetics

When applied topically, oxymetazoline hydrochloride does not exhibit systemic effects. When administered intranasally, the half-life is 35 hours or more. Approximately 2.1% of the drug is excreted in urine, and 1.1% in feces.

Indications for use

  • acute respiratory diseases (ARI), accompanied by a runny nose (symptomatic therapy);
  • allergic rhinitis;
  • vasomotor rhinitis (for drops);
  • rhinitis of infectious-inflammatory nature (for spray);
  • otitis media;
  • eustachitis;
  • sinusitis;
  • hay fever.

According to the instructions, Oxymetazoline is also recommended for use to relieve swelling before rhinoscopy or other manipulations in the nasal passages.

Contraindications

  • angle-closure glaucoma;
  • atrophic rhinitis;
  • condition after transsphenoidal hypophysectomy;
  • history of surgical interventions on the dura mater;
  • age up to 1 year – for drops 0.025%;
  • age up to 6 years – for 0.05% drops and spray;
  • combined use with monoamine oxidase inhibitors (MAOIs), as well as a two-week period before and after completion of therapy with the latter;
  • pregnancy - for drops, depending on the manufacturer;
  • hypersensitivity to any of the components of the drug.

Relative (oxymetazoline is prescribed with extreme caution):

  • diseases of the cardiovascular system: arterial hypertension, arrhythmias, chronic heart failure, tachycardia, lesions of the coronary arteries, severe atherosclerosis;
  • chronic renal failure;
  • increased intraocular pressure;
  • diabetes;
  • hyperthyroidism;
  • pheochromocytoma;
  • porphyria;
  • prostatic hyperplasia (urinary retention);
  • pregnancy and breastfeeding;
  • combined use with tricyclic antidepressants, bromocriptine and other drugs that lead to an increase in blood pressure (BP).

Instructions for use of Oxymetazoline: method and dosage

Oxymetazoline is administered intranasally.

Nasal spray

Before each administration of the spray, the bottle must be shaken vigorously.

For children over 6 years of age and adults, it is recommended to apply 1 injection into each nasal passage at intervals of 10–12 hours. If the therapeutic effect is insufficient in adults, the frequency of use can be increased to 3 times a day. The indicated dose should not be exceeded.

Before using the bottle for the first time, it is necessary to calibrate it by pressing the head of the nozzle or spray pump several times.

If you need to take a course longer than 5 days, you should consult your doctor.

Nasal drops

Recommended single doses and frequency of administration (per day), taking into account the patient’s age and dosage of the drug:

  • children under 1 year: 0.01% solution - from birth to the 5th week of life, prescribed 2-3 times or 1 time (depending on the manufacturer), 1 drop in each nasal passage; from the 5th week to 1 year - 2-3 times, 1-2 drops in each nasal passage;
  • children from 1 year to 6 years: 0.025% solution - 2-3 times, 1-2 drops in each nasal passage;
  • children over 6 years old and adults: 0.05% solution - 2-3 times, 1-2 drops in each nasal passage.

Oxymetazoline drops should not be used for more than 7 days.

Side effects

  • cardiovascular system: uncommon – increased blood pressure, palpitations, tachycardia; extremely rarely - arrhythmia;
  • nervous system: rarely - headache, anxiety, fatigue (loss of energy, drowsiness), insomnia, hallucinations;
  • respiratory system: often – burning/dryness of the nasal mucosa (transient), hypersecretion, sneezing, for spray – dry mouth and throat; uncommon – reactive hyperemia (increased swelling of the nasal mucosa), nosebleeds.

Adverse reactions caused by the systemic effect of oxymetazoline may include dizziness, sleep disturbances (in children), increased anxiety, irritability, itching, Quincke's edema, exanthema, nausea, blurred vision (if in contact with the eyes), respiratory arrest (in infants), convulsions.

Against the background of long-term and continuous treatment with vasoconstrictor drugs, drug-induced rhinitis (recurrent swelling of the nasal mucosa), tachyphylaxis, and atrophy of the nasal mucosa may occur.

Overdose

Symptoms of overdose may include fever, vomiting, nausea, cyanosis, dilated pupils, mental disorders, shortness of breath, arterial hypertension, arrhythmia, tachycardia, cardiac arrest, pulmonary edema, depression of the central nervous system (decreased blood pressure, decreased body temperature, drowsiness, bradycardia, arrest breathing and coma).

Treatment in case of overdose is recommended to be symptomatic. In case of accidental oral administration of the drug, gastric lavage and activated charcoal are prescribed to evacuate the contents of the gastrointestinal tract; these measures should be carried out immediately since oxymetazoline is rapidly absorbed. If blood pressure decreases, selective alpha-blockers cannot be used. If necessary, anticonvulsants and antipyretics are administered and artificial ventilation is prescribed. Vasopressor drugs are contraindicated for use.

special instructions

You must be careful not to get Oxymetazoline into your eyes.

Continuous therapy with the drug should not be carried out for more than 7 days.

In case of prolonged or frequent use of the drug, symptoms of nasal congestion may recur or worsen. If this effect occurs, you must stop treatment and consult a specialist.

The nasal drops contain benzalkonium chloride, which can cause swelling and irritation of the nasal mucosa.

Impact on the ability to drive vehicles and complex mechanisms

When using Oxymetazoline spray and drops in therapeutic doses, no negative effect on the ability to drive vehicles or operate complex machinery was noted. However, with a long course of treatment using high doses, the possibility of developing systemic adverse reactions of the drug cannot be excluded. In this case, it is necessary to exercise caution when performing work that requires special concentration and quick reactions.

Use during pregnancy and lactation

There are no clinical data confirming the safety of using the drug during pregnancy and lactation. As a result, Oxymetazoline should only be used in pregnant or breastfeeding women in extreme cases, when, in the opinion of the attending physician, the expected benefit of drug therapy for the mother significantly outweighs the possible risk to the fetus/child.

Use in childhood

Children under 6 years of age are contraindicated to use spray and drops of 0.05%, children under 1 year of age - drops of 0.025%.

For impaired renal function

In the presence of chronic renal failure, it is recommended to use Oxymetazoline with extreme caution.

Drug interactions

  • local anesthetic drugs: their absorption slows down and the effect is prolonged;
  • MAO inhibitors (including 14 days before and after their use), other drugs that cause an increase in blood pressure: the risk of arterial hypertension is aggravated;
  • tricyclic antidepressants: the risk of arrhythmia and hypertension increases;
  • other vasoconstrictor drugs: the likelihood of adverse reactions increases.

Analogs

Analogues of Oxymetazoline are Afrin, Nazivin, Afrin extro, Nazol Advance, Nazivin Sensitive, Nazo-spray, Vicks Active Sinex, Nazol, Nesopin, Otrivin, Noxprey, Rinostop Extra, Oxyfrin, Sialor.

Terms and conditions of storage

Store at a temperature of 0–25 °C, in a place protected from light, out of reach of children.

The shelf life of the spray is 3 years, drops – 2 years.

Conditions for dispensing from pharmacies

Available without a prescription.

Reviews about Oxymetazoline

According to most reviews, Oxymetazoline is an effective and inexpensive drug that helps adults and children quickly eliminate nasal congestion and reduce swelling of the nasal mucosa. Patients confirm that nasal breathing is restored within 5–10 minutes after administration of drops or spray, and this effect lasts up to 10–12 hours.

The disadvantages of Oxymetazoline include adverse reactions, the most common of which are transient dryness and burning that occur after its administration.

Price for Oxymetazoline in pharmacies

There is no reliable data on the price of Oxymetazoline, since the drug is currently not on sale.

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Source: http://www.neboleem.net/oksimetazolin.php

How to take Oxymetazoline nasal drops?

Oxymetazoline is a drug that belongs to the group of adrenergic agonists. The drug helps to constrict blood vessels that dilate due to the inflammatory process in the nasopharynx.

After instilling the solution, the patient's swelling of the nasal mucosa decreases and breathing is restored. Signs of improvement can be noticed within 15 minutes after using the drug. The therapeutic effect lasts for hours.

Release form

Oxymetazoline is sold in pharmacies in the form of drops or spray. The volume of the bottle is 10 or 20 ml.

Composition of the drug

The solution contains oxymetazoline hydrochloride, which helps to narrow the vessels of the nasal mucosa. Depending on the release form, the content of the active substance is 0.1 mg, 0.25 mg or 0.5 mg. When choosing a remedy, doctors take into account the patient’s age and individual characteristics.

pharmachologic effect

When the drug comes into contact with the nasal mucosa, it helps reduce swelling. A person's nasal congestion disappears and mucus production decreases.

When undergoing a course of treatment, you must not exceed the dose indicated in the instructions. The solution has a local effect and is eliminated from the body naturally.

Contraindications

Oxymetazoline should not be taken by patients suffering from diabetes mellitus or hypertriosis. Doctors do not recommend using nasal drops with oxymetazoline hydrochloride in patients with atrophic rhinitis.

Oxymetazoline increases blood pressure. The solution can cause harm in cases of atherosclerosis and thyrotoxicosis.

The drug is contraindicated for people who are allergic to the components of Oxymetazoline.

Side effects

After instilling the solution, the patient may experience unpleasant symptoms:

Experts strictly limit the period of use of Oxymetazoline. This is due to the fact that long-term use of the drug can lead to hyperemia of the mucous membranes.

Long-term use of the drug leads to dystrophic changes in the nasal mucosa. To avoid complications, the doctor prescribes solutions to the patient with a reduced content of the active substance.

What is prohibited from taking at the same time as Oxymetazoline?

The drug reduces the medicinal effect of anesthetics, as it slows down their absorption.

The solution should not be instilled into the nose if the patient is taking medications that increase blood pressure. This can lead to serious consequences for glaucoma.

Oxymetazoline is incompatible with antidepressants, as this can lead to hypertension and arrhythmia. The drug can be instilled only 2 weeks after discontinuation.

Oxymetazoline provokes the development of mucosal atrophy. Before using the drug, you should definitely consult your doctor.

The benzalkonium chloride contained in the solution causes irritation and swelling of the nasal mucosa in some patients.

Overdose

Instillation of the solution into the nose for more than 5 days leads to the patient’s disruption of the process of fluid regulation in the mucosal cells. Prolonged use of the drug causes addiction in the patient.

This reduces the therapeutic effect of Oxymetazoline. To restore nasal breathing, the patient has to resort to drops much more often.

Exceeding the dose established in the instructions can be recognized by several signs:

  • the patient's pupils dilate;
  • attacks of nausea appear;
  • lungs swell;
  • body temperature drops and the nervous system is depressed.

Overdose is especially dangerous for young children. In children, atrophy of the mucous membranes develops quite quickly.

How to take the drops

Instructions for using Oxymetazoline nasal drops require strict adherence to the dosage. To help adult patients, it is enough to inject 1-2 drops of a solution containing 0.05% of the active substance into the nasal sinuses. To eliminate the symptoms of a runny nose, the remedy should be instilled 2-3 times a day.

When treating children aged 1 to 6 years, it is recommended to use a drug with a reduced concentration of oxymetazoline hydrochloride. The solution should be instilled 1-2 drops 2-3 times a day.

Treatment of infants up to one year requires a special approach. Doctors prescribe drops for young children containing 0.01% of the active ingredient.

Thanks to such a low dose, you can avoid side effects that often occur in your baby. The product should be dripped 2-3 times a day, 1-2 drops.

Important! Oxymetazoline should not be used for more than 5 days. If there are no positive results, you should consult a doctor.

For the treatment of children under 6 years of age, it is allowed to use the drug only in the form of drops. This ban is due to the fact that the spray at this age can cause suffocation. Each bottle is equipped with a special nozzle that facilitates the process of injecting the product. The drug should be injected into each nostril 2-3 times a day.

Can I take nasal drops during pregnancy?

Oxymetazoline is considered a strong drug that lasts about 10 hours.

It may have a negative effect on the development of the fetus.

These drops are especially dangerous during the 1st and 2nd trimester, when the baby’s important organs are forming.

Doctors do not recommend using Oxymetazoline to treat a runny nose during this period.

What can replace Oxymetazoline?

There are analogs that can be used as an alternative to Oxymetazoline.

These drugs include:

Doctors prescribe these drugs in cases where the patient has an individual intolerance to the components of Oxymetazoline.

Conclusion

Oxymetazoline is intended to constrict blood vessels and reduce swelling of the mucous membranes. The drug begins to act immediately after contact with the surface of the nasal mucosa. Within a few minutes, the patient gets rid of nasal congestion, which complicates breathing.

The duration of action of the solution reaches 10 hours. However, this remedy does not eliminate the cause of the runny nose, but only temporarily relieves the manifestations of the disease. The patient is prohibited from using Oxymetazoline for more than 5 days, as it has a negative effect on the nasal mucosa.

Directory of main ENT diseases and their treatment

All information on the site is for informational purposes only and does not claim to be absolutely accurate from a medical point of view. Treatment must be carried out by a qualified doctor. By self-medicating you can harm yourself!

Source: http://gorlonos.com/kapli/kak-prinimat-v-nos-oksimetazolin.html

Oxymetazoline

Description current as of 03/07/2015

  • Latin name: Oxymetazoline
  • ATX code: S01GA04
  • Active ingredient: Oxymetazoline (Oxymetazoline)
  • Manufacturer: UPDATE (Russia), PHARMSTANDARD-LEKSREDSTVA (Russia), Pharmtechnology (Belarus)

Compound

One milliliter of Oxymetazoline nasal drops contains 500, 100 or 250 mcg of oxymetazoline hydrochloride.

One milliliter of Oxymetazoline spray contains 500 mcg of oxymetazoline hydrochloride.

Additional substances: 12-water disodium phosphate, sodium hydroxide solution, disodium edetate, dihydrate sodium phosphate, benzalkonium chloride, water.

Release form

Nasal drops are a colorless transparent liquid.

  • 2 ml of liquid in a dropper tube; one, five or twenty dropper tubes in a cardboard pack.
  • 10 ml of liquid in a dropper tube; one, five or twenty dropper tubes in a cardboard pack.
  • 15 ml of liquid in a dropper tube; one, five or twenty dropper tubes in a cardboard pack.
  • 20 ml of liquid in a dropper tube; one, five or twenty dropper tubes in a cardboard pack.

The nasal spray is a colorless, clear liquid.

  • 15, 10 or 20 ml of liquid in a polyethylene bottle with a spray nozzle; one bottle in a cardboard pack.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

Adrenomimetic type agent for local use. Has a vasoconstrictor effect. When administered intranasally, swelling of the mucous membranes of the respiratory tract is reduced. When administered into the conjunctival sac, it reduces swelling of the conjunctiva.

The effect appears a quarter of an hour after application and lasts for 7-8 hours.

Indications for use

  • Swelling of the conjunctiva.
  • Rhinitis with colds, eustachitis, inflammation of the sinuses, allergic diseases, hay fever.

Contraindications

Side effects

  • Reactions from breathing: temporary burning and dryness of the nasal mucosa, sneezing, dry mouth, reactive hyperemia or atrophy of the mucous membranes.
  • Reactions from the blood circulation: increased heart rate, arterial hypertension.
  • Reactions from the nervous system: excitability, dizziness, tachyphylaxis, headache, sleep disturbances.
  • Digestive reactions: nausea.
  • Reactions from the visual side: with the conjunctival route of administration, the development of mydriasis, irritation of the conjunctiva, accommodation paresis, and eyelid retraction is possible.

Instructions for use of Oxymetazoline (Method and dosage)

Children over 6 years old and adults are recommended to instill 1-2 drops of the drug into both nostrils up to two times a day.

For congestive processes and swelling of the conjunctiva, use 1-2 drops of the product in each eye.

At the recommended dosage, Oxymetazoline can be used alone for up to three days. If no visible improvement is observed within the specified period of time, you should consult a doctor.

Overdose

When used topically, an overdose is unlikely.

Interaction

Oxymetazoline inhibits the absorption of local anesthetics and prolongs their duration of action.

When co-administered with tricyclic antidepressants and MAO inhibitors, blood pressure may increase.

The simultaneous administration of other vasoconstrictor drugs increases the likelihood of developing undesirable effects.

Terms of sale

Storage conditions

Store at room temperature. Keep away from children.

Best before date

special instructions

It is advised to avoid contact of the product intended for nasal use with the eyes.

In recommended dosages, Oxymetazoline can be used for up to 3 days without consulting a doctor.

The drug affects vision, and the reaction may also slow down, which must be taken into account when driving.

Analogs

For children

Children 1-7 years old are recommended to instill 1-2 drops of a 0.025% solution into both nostrils twice a day. In children over 7 years of age, adult dosages of the drug are used.

During pregnancy and lactation

The drug is not intended for use during the specified periods.

Reviews

According to patients, Oxymetazoline effectively relieves swelling and restores breathing through the nose for up to 8 hours. There are almost no cases of side effects.

Oxymetazoline price, where to buy

The price of Oxymetazoline in drops 0.01% 10 ml in Russia starts from 40 rubles.

Education: Graduated from Vitebsk State Medical University with a degree in Surgery. At the university he headed the Council of the Student Scientific Society. Advanced training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".

Work experience: Worked in a general medical network for 3 years as a surgeon (Vitebsk Emergency Hospital, Liozno Central District Hospital) and part-time as a district oncologist and traumatologist. Worked as a pharmaceutical representative for a year at the Rubicon company.

Presented 3 rationalization proposals on the topic “Optimization of antibiotic therapy depending on the species composition of microflora”, 2 works took prizes in the republican competition-review of student scientific works (categories 1 and 3).

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All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/oksimetazolin

Oxymetazoline

Oxymetazoline instructions

Oxymetazoline is an alpha-adrenomimetic, anticongestive, vasoconstrictor drug for topical use. When administered intranasally, it causes a narrowing of small vessels (arterioles and venules) of the nasal mucosa, which reduces the local inflammatory process, hyperemia and swelling, resulting in easier nasal breathing in viral, bacterial and allergic rhinitis and sinusitis.

Oxymetazoline has several forms of release in the form of an aerosol for intranasal use, containing 1 milliliter microgram of oxymetazoline hydrochloride in a bottle of 20 and 30 milliliters and in the form of intranasal drops with a concentration of 0.025% and 0.05% in bottles of 10 milliliters.

Indications for use of Oxymetazoline

This drug is widely used for the symptomatic treatment of acute inflammatory processes in the nasal cavity of allergic, bacterial or viral origin: rhinitis, otitis, eustachitis, sinusitis, hay fever and hay fever. This drug is also part of complex therapy for laryngitis and nasopharyngitis to relieve symptoms and reduce hyperemia, swelling and exudative processes of the nasal cavity and for swelling and congestion of the conjunctiva (used in the form of eye drops).

Directions for use and dosage of Oxymetazoline

Adult patients and children over seven years of age are prescribed Oxymetazoline in a solution of 0.05%, one to two drops intranasally two to three times a day or 0.05% nasal spray, one injection intranasally two to three times a day. Children aged from one to seven years are prescribed Oxymetazoline at a concentration of 0.025% intranasally, one to two drops two to three times a day for no more than 3 days.

Contraindications to the use of Oxymetazoline

The use of Oxymetazoline is contraindicated in case of hypersensitivity to the active active substance or auxiliary substances, atrophic rhinitis, hyperthyroidism, diabetes mellitus, angle-closure glaucoma, and during pregnancy and lactation. Also, Oxymetazoline is not prescribed for severe atherosclerosis, heart failure, arterial hypertension, arrhythmia and severe renal or liver failure.

Side effects of Oxymetazoline

With frequent and prolonged use of Oxymetazoline in high doses, side effects may occur - palpitations, headache, sneezing and burning and discomfort of the nasal mucosa, insomnia, increased excitability, dizziness, nausea.

Oxymetazoline overdose

Symptoms of overdose are nausea, constriction of the pupils, vomiting, cyanosis, tachycardia, increased body temperature, arrhythmia, increased blood pressure. With the simultaneous use of high doses of Oxymetazoline, mental disorders may occur, which are accompanied by drowsiness, and pathological conditions with bradycardia, severe arterial hypotension, and with the possible development of pulmonary edema, coma and cardiac and respiratory arrest.

Oxymetazoline for children

Oxymetazoline is a local anticongestive and vasoconstrictor drug for the treatment of acute and chronic allergic, bacterial and viral catal inflammatory processes of the nasal cavity: rhinitis and sinusitis, hay fever and hay fever. This drug is also part of complex therapy for otitis, eustachitis, laryngitis and nasopharyngitis to relieve the symptoms of the underlying disease to reduce swelling, hyperemia and exudative processes in the nasal cavity.

In adolescence and childhood (over seven years of age), Oxymetazoline is prescribed at a concentration of 0.05% in a dosage of one to two drops two to three times a day intranasally or 0.05% nasal spray, one injection into each nostril two to three times. per day. Children aged from one to seven years are prescribed Oxymetazoline at a concentration of 0.025% intranasally, one to two drops two to three times a day for no more than 3 days.

It is important for parents to remember that the use of this drug in childhood is necessary only as directed and under the dynamic supervision of the attending physician, observing the dosage and frequency of administration of nasal drops or spray. If therapeutic doses of Oxymetazoline are exceeded, side effects or symptoms of overdose may occur. If you experience burning and dryness of the nasal mucosa, sneezing, arrhythmia, nausea and vomiting. Symptoms of overdose are arterial hypotension, bradycardia, drowsiness, coma and respiratory and cardiac arrest.

If you experience symptoms of an overdose or side effects in connection with the use of Oxymetazoline drug, you should immediately stop taking this drug and seek medical help. In case of acute overdose symptoms, treatment is prescribed in a hospital setting - symptomatic pathogenetic therapy.

Oxymetazoline during pregnancy

The decongestant vasoconstrictor drug Oxymetazoline is contraindicated at any stage of pregnancy, which is associated with a possible risk of side effects in the mother and adverse effects on the fetus.

Oxymetazoline analogues

Analogs of Oxymetazoline are drugs - Nazivin (Germany), Fazin (USA), Nazol (USA), Fervex spray for the common cold (Canada), Oxymetazoline (Belarus).

Oxymetazoline prices

The cost of drugs with the active ingredient - Oxymetazoline: Nazivin in nasal drops - from 97 to 130 rubles, Nazol spray - 205 - 247 rubles, Vicks Active Sinex - 250 - 288 rubles, Oxymetazoline drops rubles.

Oxymetazoline reviews

Oxymetazoline is an effective anticongestive agent that causes constriction of small arterioles and venules of the mucous membranes of the nose, eustachian tube and paranasal sinuses, resulting in a long-term and gentle reduction in swelling and inflammation of the mucous membranes, which leads to easier breathing and the outflow of mucus during sinusitis.

Oxymetazoline nasal spray contains menthol, camphor and eucalyptol, which have additional local anti-inflammatory, anti-edematous and antiseptic effects, improve the outflow of mucus from the paranasal sinuses, diluting it, and help increase the duration of action of this drug.

This drug is widely used for the treatment of rhinitis of infectious and allergic origin, otitis, eustachitis and sinusitis. This drug is also used for symptomatic treatment of laryngitis and nasopharyngitis to reduce swelling, hyperemia and exudative processes in the nasal cavity and sinuses.

It is important to remember that the use of this drug is contraindicated in case of individual hypersensitivity to Oxymetazoline, atrophic rhinitis, hyperthyroidism, diabetes mellitus, pregnancy and lactation. Also, Oxymetazoline is not prescribed for severe atherosclerosis, arrhythmia, arterial hypertension and severe renal or liver failure.

Source: http://nasmork-rinit.com/meditsinskie-preparaty/232-oksimetazolin

Oxymetazoline nasal drops - instructions for use

Having no idea about the real pharmacological properties of nasal medications, many are guided by doctors’ prescriptions. It is important for us that the discomfort stops and the nose does not run.

Oxymetazoline: pharmacological properties, composition, price of the drug

A large selection of nasal products makes it difficult to choose the right one for each individual case. Guided by a doctor's prescription and not receiving the desired effect, a person with a cold has a desire to choose a remedy that will relieve a runny nose in the shortest possible time.

As an option, we offer a drug that has a quick and effective effect on the symptoms of a runny nose - Oxymetazoline, the instructions for the action of which will cover in detail all the questions that arise for those who have never used this remedy.

Oxymetazoline: clinical and pharmacological group - a vasoconstrictor drug for topical use for the common cold and conjunctivitis.

The medicine is recommended as the most suitable remedy for eliminating inflammation of the nasal mucosa, as it effectively constricts blood vessels and reduces swelling. The effect of the drug begins immediately after instillation into the nose. This is its main advantage over other drugs.

Drops with oxymetazoline are administered for inflammation of the sinuses, allergic manifestations, and are prescribed for use 2 times a day. The effect of the drug lasts 8 hours, during this period breathing normalizes, the nasal mucosa dries out, discharge stops, and the inflammatory process begins to decrease.

Oxymetazoline (nasal drops) when used topically is practically not absorbed into the blood. Even with a short stay in the nasal cavity, the product manages to have a therapeutic effect, so there is reason to talk about its high effectiveness.

The drug contains active substances:

  • Oxymetazoline hydrochloride.
  • Menthol.
  • Eucalyptus oil.
  • Sodium phosphate, aqueous.
  • Edetate disodium.
  • Benzalkonium chloride.
  • Sodium hydroxide solution.

The synthesis of these components eliminates congestion, allergic reactions, and swelling of the conjunctiva. This is the resorptive effect of oxymetazoline hydrochloride. Like many vasoconstrictor drugs, oxymetazoline is addictive after 5 days of use, but during this time it manages to have a therapeutic effect.

Drops are produced in droppers - tubes of 2, 10, 15, 20 ml with a separate sprayer; they are a transparent liquid. The cost of the drug depends on the volume of the tube and on the manufacturer, but is considered acceptable and ranges from 70 to 160 rubles.

Directions for use and dosage

The drug is prescribed for a runny nose in both adults and children. The frequency of instillation depends on the degree of nasal congestion, but, according to the instructions, it is undesirable to exceed the dose for adults more than 3 times a day, 2 drops. Oxymetazoline for children is indicated for patients aged 1 to 7 years, 1 drop 2 times a day.

You can buy oxymetazoline on your own without a doctor's prescription. In this case, it is recommended to use it for no more than 3 days. If swelling and nasal congestion do not go away, you should consult a doctor.

Advantages and disadvantages of the drug

Like any medicine, oxymetazoline has advantages and disadvantages.

First of all, it is necessary to mention the possible side effects of the drops:

  • The appearance of dryness and itching of the nasal mucosa.
  • Dry throat and mouth.
  • Increased blood pressure.
  • Nausea.
  • Dizziness.
  • Cardiopalmus.
  • Redness of the mucous membrane.

At the first sign of side effects, you should stop using the drug. This means that the patient’s body does not accept it. Side effects may occur if the instructions for use, which are important for oxymetazoline, are not followed, therefore it is necessary to follow the recommended doses and shelf life of the drug.

All the benefits of oxymetazoline will be fully realized if you adhere to the doctor’s recommendations: the burning and itching in the nose and the discharge accompanying a runny nose will stop. When using oxymetazoline to treat children, instructions for use and its strict use are mandatory to avoid undesirable consequences.

A distinctive feature of the drops is that they can effectively treat conjunctivitis. For swelling of the conjunctiva of the eye, instillation of a drop into each eye once a day is prescribed.

Contraindications for use

The insidiousness of oxymetazoline lies in its vasoconstrictor effect, unless the patient first finds out whether this drug is contraindicated for him. The main contraindication is the presence of hypersensitivity to the drug. This may appear during the initial stage of use or during a medical examination.

  • Hypertension.
  • Tachycardia.
  • Chronic renal failure.
  • Severe form of atherosclerosis.
  • Glaucoma.
  • Heart failure.
  • Diabetes mellitus.
  • Diseases of the thyroid gland.

Oxymetazoline is not recommended for use during pregnancy in the first two trimesters, as it is considered the most powerful of the nasal drugs. It affects not only the body of the expectant mother, but also the child, which is undesirable.

There are many other drugs that will not harm the developing body, so in order to avoid the risk of harming the baby, it is recommended that a pregnant woman not get carried away with such powerful drugs for treating a runny nose.

Analogues of the drug

In pharmacology, it is customary to divide drugs into analogues and synonyms. Drugs with the same substance are called synonyms, and analogues are drugs that are intended to treat the same diseases, but have different names.

Analogs of oxymetazoline, as close as possible to the original, are developed by large companies with modern equipment that produce the drug with a high degree of purification from impurities.

Analogues of Oxymetazoline with other names are produced by manufacturers all over the world: Afrin, Nazivin, Nazol, Nazospray, Fervex spray, Nesopin, Noxprey and many others. Their action is similar to the original, all differences are mentioned in the instructions for use.

The choice of drops for a runny nose in pharmacies is very large, but you should not experiment with your health and purchase products based on the indicators you like: low price, beautiful packaging, advice from a neighbor.

The human body is individual, and the selection of a drug should be based on this. Therefore, a doctor must prescribe a drug for treatment.

Source: http://moylor.ru/lekarstva/kapli-v-nos-oksimetazolin/

5 Popular Oxymetazoline Drugs

Oxymetazoline is a local adrenergic agonist that reduces swelling of the mucous membrane. It begins to act after 15 minutes and lasts up to 8 hours (sometimes up to 12 hours). Significantly less likely to cause drug-induced rhinitis, compared to xylometazoline, and has a longer effect. Let's compare the drugs in this group, their advantages and disadvantages.

All drugs containing oxymetazoline are not prescribed to children under one year of age (in the form of drops), under 6 years of age (in the form of a spray), pregnant women (categorically), with diabetes mellitus and impaired renal function, atrophic rhinitis. Use twice a day. Continuous therapy for no more than 3 days. Consult your doctor.

Oxymetazoline drugs:

Oxymetazoline preparations: Nazivin, Nazol, Fazin, Nesopin, Fervex (spray)

Nazivin

In addition to oxymetazoline, it contains the antiseptic benzalkonium chloride and distilled water. Produced in the form of a spray or drops. Gives an instant, soft and long-lasting effect. Helps with severe congestion. The substances included in the composition improve the discharge of mucus. Do not use during pregnancy and lactation.

Nazol

Oxymetazoline drug. Suitable for children and adults (appropriate shapes). The glycerin contained in the composition has a moisturizing and softening property. Can be used together with other means.

  • up to 6 years old Nazol Baby,
  • Nazol Kids (6-12 years old),
  • Nazol (has a concentration of 0.025%) and Nazol Advance (concentration 0.05%) are prescribed from 6 years of age and for adults.

Fazin

Constricts the arterioles of the nasal mucosa. It comes in the form of nasal drops and spray for children and adults. Indications: rhinitis, eustacheitis, chronic sinusitis, pharyngitis, nasopharyngitis, otitis media.

Drops with oxymetazoline are contraindicated for up to a year, for chronic heart failure, dry rhinitis, and for pregnant women. The spray is not used for diabetes and hyperthyroidism. 1-6 years - after consulting a doctor. The effect lasts up to 8 hours. Do not allow the nasal preparation to come into contact with the eyes, as it is likely to reduce the reaction and affect vision.

Nesopin

Russian-made nasal spray. In addition to oxymetazoline, the substances included in the composition (menthol, camphor, eucalyptus oil) thin mucus, improving its outflow, have anti-inflammatory and antiseptic properties, and increase the duration of action.

Fervex (spray for runny nose)

Spray with oxymetazoline to treat a runny nose. Prescribed for hay fever, colds, rhinitis, sinusitis. Contraindicated for pregnant women, nursing mothers and children under one year of age. With caution up to 6 years. It is not advisable to use for a long time due to the risk of damage to the mucous membrane. Side effects: sneezing, irritation and dry mucous membranes.

Source: http://mednews.info/5-popyliarnyh-preparatov-oksimetazolina/