Nurofen instructions for use syrup

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Nurofen - instructions for use, reviews, analogs and formulations (tablets 200 mg, forte, plus, children's syrup or suspension, suppositories 60 mg, gel 5%) medications for the treatment of pain and fever in adults, children and pregnancy

In this article you can read the instructions for use of the drug Nurofen.

Table of contents:

Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Nurofen in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Nurofen in the presence of existing structural analogues. Use for the treatment of pain and fever (high temperature) in adults, children, and during pregnancy and lactation. Children's forms and their use.

Nurofen is a non-steroidal anti-inflammatory drug, a derivative of phenylpropionic acid. It has anti-inflammatory, analgesic and antipyretic effects.

The mechanism of action is associated with inhibition of the activity of COX, the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to both peripheral (indirectly, through suppression of prostaglandin synthesis) and central mechanisms (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Suppresses platelet aggregation.

When applied externally, it has an anti-inflammatory and analgesic effect. Reduces morning stiffness and helps increase range of motion in joints.

After oral administration, ibuprofen (the active ingredient of Nurofen) is quickly absorbed from the gastrointestinal tract. Plasma protein binding is 90%. Slowly penetrates into the joint cavity, lingers in the synovial tissue, creating higher concentrations in it than in plasma. Ibuprofen is excreted in the urine unchanged (no more than 1%) and in the form of conjugates, a small part is excreted in the bile.

  • headache;
  • migraine;
  • toothache;
  • neuralgia;
  • myalgia;
  • back pain;
  • rheumatic pains;
  • algodismenorrhea;
  • fever with influenza and ARVI.

Film-coated tablets 200 mg.

Tablets for the preparation of an effervescent drink 200 mg.

Rectal suppositories 60 mg (children's form of the drug).

Tablets Nurofen forte 400 mg.

Nurofen plus tablets (contains ibuprofen + codeine).

Children's syrup or suspension with orange or strawberry flavor 100 mg.

Gel for external use 5%.

Instructions for use and dosage

For adults and children over 12 years of age, the initial dose of the drug is 200 mg 3-4 times a day. To achieve a rapid clinical effect, it is possible to increase the initial dose to 400 mg 3 times a day. Maximum daily dose mg.

Children aged 6 to 12 years - 200 mg no more than 4 times a day. It should be taken into account that the drug can only be prescribed to children weighing more than 20 kg. The interval between taking tablets should be at least 6 hours.

You should not take more than 6 tablets per day. Maximum dose -1.2 g.

Film-coated tablets should be taken with water. Effervescent tablets should be dissolved in 200 ml of water (1 glass).

For fever and pain, the dose of the drug depends on the age and body weight of the child. A single dose is 5-10 mg/kg 3-4 times a day. The maximum daily dose is 30 mg/kg.

Children aged 3-9 months (body weight 5.5-8 kg) are prescribed 1 supp. (60 mg) 3 times a day with an interval of 6-8 hours, but not more than 180 mg per day.

Children aged 9 months to 2 years (body weight 8-12.5 kg) are prescribed 1 supp. (60 mg) 4 times a day with an interval of 6 hours, no more than 240 mg per day.

For post-immunization fever, children under 1 year of age are prescribed 1 supp. (60 mg); children over 1 year also - 1 supp. (60 mg), if necessary, after 6 hours you can introduce another 1 supp. (60 mg).

Duration of treatment: no more than 3 days as an antipyretic, no more than 5 days as an analgesic. If fever persists, consult a doctor.

Do not exceed the indicated doses of the drug.

Suspension or syrup for children

For fever and pain, the drug is prescribed in a dose of 5-10 mg/kg body weight of the child 3-4. The maximum daily dose should not exceed 30 mg/kg body weight.

As an antipyretic, the drug should not be taken for more than 3 days, and as an analgesic - no more than 5 days.

For fever after immunization, the drug is prescribed at a dose of 50 mg (2.5 ml); if necessary, children over 1 year of age can re-take the drug in the same dose after 6 hours. The maximum daily dose should not exceed 5 ml (100 mg).

The suspension should be shaken thoroughly before use.

For precise dosing of the suspension, a double-sided measuring spoon (2.5 ml and 5 ml) or a measuring syringe is attached to the bottle.

When using Nurofen for 2-3 days, practically no side effects are observed. In case of long-term use, the following side effects may occur:

  • nausea, vomiting;
  • heartburn;
  • anorexia;
  • feeling of discomfort in the epigastrium;
  • diarrhea;
  • flatulence;
  • erosive and ulcerative lesions of the gastrointestinal tract (in some cases complicated by perforation and bleeding);
  • abdominal pain, irritation;
  • dryness and pain in the oral mucosa;
  • constipation;
  • headache;
  • dizziness;
  • insomnia, agitation, drowsiness, depression;
  • confusion, hallucinations;
  • blurred vision;
  • dryness and irritation of the eyes;
  • hearing loss, ringing or noise in the ears;
  • increased blood pressure;
  • tachycardia;
  • nephrotic syndrome;
  • acute renal failure;
  • anemia (including hemolytic, aplastic);
  • thrombocytopenia;
  • thrombocytopenic purpura;
  • agranulocytosis;
  • leukopenia;
  • skin rash, itching, urticaria, angioedema, anaphylactoid reactions, anaphylactic shock;
  • allergic rhinitis;
  • bronchospasm, shortness of breath;
  • increased sweating.

With long-term use in high doses: ulceration of the gastrointestinal mucosa, bleeding (including from the gastrointestinal tract, gums, uterine, hemorrhoidal), visual impairment (impaired color vision, scotoma, amblyopia).

  • erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, incl. peptic ulcer of the stomach and duodenum, ulcerative colitis, peptic ulcer, Crohn's disease;
  • severe heart failure;
  • severe arterial hypertension;
  • “aspirin” bronchial asthma, urticaria, rhinitis, provoked by taking acetylsalicylic acid (salicylates) or other NSAIDs;
  • diseases of the optic nerve, impaired color vision, amblyopia, scotoma;
  • deficiency of glucose-6-phosphate dehydrogenase;
  • hemophilia, hypocoagulation conditions;
  • leukopenia;
  • hemorrhagic diathesis;
  • severe dysfunction of the liver and/or kidneys;
  • hearing loss, pathology of the vestibular apparatus;
  • 3rd trimester of pregnancy;
  • lactation period (breastfeeding);
  • children under 6 years of age;
  • hypersensitivity to ibuprofen or to the components of the drug.

Use during pregnancy and breastfeeding

Nurofen is contraindicated for use in the 3rd trimester of pregnancy.

The use of the drug in the 1st and 2nd trimesters of pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or infant.

If it is necessary to prescribe the drug during lactation, the issue of stopping breastfeeding should be decided.

If side effects occur, you should stop taking the drug and consult a doctor.

If symptoms persist after taking the drug for 2-3 days, the drug should be discontinued and the diagnosis clarified.

During the treatment period, it is not recommended to consume ethanol (alcohol) - it increases the risk of developing gastric bleeding.

When taking effervescent tablets, patients on a hypopotassium diet should take into account that 1 tablet contains 1530 mg of potassium carbonate; patients with diabetes mellitus should take into account that 1 tablet contains 40 mg of sodium saccharinate; Patients with fructose intolerance should take into account that 1 tablet contains about 376 mg of sorbitol.

Control of laboratory parameters

During long-term use of the drug, it is necessary to monitor the peripheral blood picture and the functional state of the liver and kidneys. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a general blood test (hemoglobin determination), and a stool test for occult blood.

Impact on the ability to drive vehicles and operate machinery

Patients should refrain from all activities that require increased attention and speed of psychomotor reactions.

Concomitant use of Nurofen with acetylsalicylic acid and other NSAIDs is not recommended.

When administered simultaneously, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (an increase in the incidence of acute coronary insufficiency may occur after starting ibuprofen in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent).

When used simultaneously with anticoagulant and thrombolytic drugs (including alteplase, streptokinase, urokinase), the risk of bleeding increases.

When used together with Nurofen, cefamandole, cefoperazone, cefotetan, valproic acid, and plicamycin increase the incidence of hypoprothrombinemia.

When used together, cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which leads to an increased nephrotoxic effect.

Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects.

Drugs that block tubular secretion, when used simultaneously, reduce the excretion and increase the plasma concentration of ibuprofen.

When used together, inducers of microsomal oxidation (including phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions.

Inhibitors of microsomal oxidation reduce the risk of developing hepatotoxic effects of ibuprofen.

When used together, Nurofen reduces the hypotensive activity of vasodilators, the natriuretic effect of furosemide and hydrochlorothiazide.

Ibuprofen reduces the effectiveness of uricosuric drugs and enhances the effect of indirect anticoagulants, antiplatelet agents and fibrinolytics.

Increases the side effects of mineralocorticoids, corticosteroids, estrogens, ethanol (alcohol).

When used together, it increases the hypoglycemic effect of oral antidiabetic agents (sulfonylurea derivatives) and insulin.

When taken simultaneously, antacids and cholestyramine reduce the absorption of Nurofen.

When used together, ibuprofen increases the blood concentration of digoxin, lithium, and methotrexate.

Caffeine enhances the analgesic effect of ibuprofen.

Analogues of the drug Nurofen

Structural analogues of the active substance:

Source: http://instrukciya-otzyvy.ru/56-nurofen-po-primeneniyu-analogi-tabletki-forte-plyus-detskiy-sirop-ili-suspenziya-svechi.html

NUROFEN FOR CHILDREN

◊ Oral suspension (orange) white or almost white in color, syrupy consistency, with a characteristic orange odor.

Excipients: polysorbate 5 mg, glycerol - 0.5 mg, maltitol syrup - 1.625 mg, sodium saccharinate - 10 mg, citric acid - 20 mg, sodium citrate - 25.45 mg, xanthan gum - 37.5 mg, sodium chloride - 5.5 mg, domiphene bromide - 0.5 mg, orange flavor 2M.5 mg, purified water - up to 5 ml.

100 ml - polyethylene terephthalate bottles (1) complete with a dosing syringe - cardboard boxes.

150 ml - polyethylene terephthalate bottles (1) complete with a dispenser syringe - cardboard boxes.

200 ml - polyethylene terephthalate bottles (1) complete with a dispenser syringe - cardboard boxes.

◊ Oral suspension (strawberry) white or almost white in color, syrupy consistency, with a characteristic strawberry odor.

Excipients: polysorbate 5 mg, glycerol - 0.5 mg, maltitol syrup - 1.625 mg, sodium saccharinate - 10 mg, citric acid - 20 mg, sodium citrate - 25.45 mg, xanthan gum - 37.5 mg, sodium chloride - 5.5 mg, domiphene bromide - 0.5 mg, strawberry flavor E - 12.5 mg, purified water - up to 5 ml.

100 ml - polyethylene terephthalate bottles (1) complete with a dosing syringe - cardboard boxes.

150 ml - polyethylene terephthalate bottles (1) complete with a dispenser syringe - cardboard boxes.

200 ml - polyethylene terephthalate bottles (1) complete with a dispenser syringe - cardboard boxes.

NSAIDs. It has analgesic, antipyretic and anti-inflammatory effects.

The mechanism of action of ibuprofen, a derivative of propionic acid, is due to inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction. Indiscriminately blocks COX-1 and COX-2, as a result of which it inhibits the synthesis of prostaglandins. In addition, ibuprofen reversibly inhibits platelet aggregation. The analgesic effect is most pronounced for inflammatory pain. The effect of the drug lasts up to 8 hours.

Suction and distribution

Absorption is high, quickly and almost completely absorbed from the gastrointestinal tract. After taking the drug on an empty stomach in adults, ibuprofen is detected in the blood plasma after 15 minutes; Cmax of ibuprofen in the blood plasma is reached after 60 minutes. Taking the drug with food can increase the time to reach Cmax by up to 1-2 hours.

Binding to blood plasma proteins is 90%. Slowly penetrates into the joint cavity, lingers in the synovial fluid, creating higher concentrations in it than in the blood plasma.

In limited studies, ibuprofen has been found in breast milk at very low concentrations.

Metabolism and excretion

After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. Metabolized in the liver.

It is excreted by the kidneys (unchanged - no more than 1%) and, to a lesser extent, with bile. T 1/2 – 2 hours.

For children from 3 months to 12 years of age as an antipyretic for infectious and inflammatory diseases and conditions accompanied by an increase in body temperature, incl. at:

— acute respiratory diseases;

— other infectious and inflammatory diseases and post-vaccination reactions.

As an analgesic for pain of mild or moderate intensity, incl. at:

- pain with sprains;

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

- complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs;

- a history of bleeding or perforation of a gastrointestinal ulcer caused by the use of NSAIDs;

- erosive and ulcerative diseases of the gastrointestinal tract (including gastric and duodenal ulcers, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or ulcerative bleeding);

- severe liver failure or active liver disease;

- severe renal failure (creatinine clearance <30 ml/min);

— the period after coronary artery bypass grafting;

- cerebrovascular or other bleeding;

— hemophilia and other bleeding disorders (including hypocoagulation);

— III trimester of pregnancy;

— child’s body weight up to 5 kg;

- hypersensitivity to ibuprofen or any of the components included in the drug.

with caution when using other NSAIDs simultaneously; a history of a single episode of gastric ulcer or ulcerative bleeding of the gastrointestinal tract, gastritis, enteritis, colitis, the presence of Helicobacter pylori infection, ulcerative colitis; bronchial asthma or allergic diseases in the acute stage or in history (possible development of bronchospasm); severe somatic diseases; systemic lupus erythematosus or mixed connective tissue disease (Sharpe's syndrome) - increased risk of aseptic meningitis; renal failure, incl. for dehydration (KKml/min), fluid retention and edema; liver failure; arterial hypertension and/or heart failure; cerebrovascular diseases; dyslipidemia/hyperlipidemia; diabetes mellitus; peripheral arterial diseases; blood diseases of unknown etiology (leukopenia, anemia); simultaneous use of other drugs that may increase the risk of ulcers or bleeding, in particular, corticosteroids for oral administration (including prednisolone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel); in the 1st and 2nd trimester of pregnancy, during breastfeeding, in elderly patients.

Nurofen for children is a drug developed specifically for children. The drug is intended for short-term use only.

The drug is taken orally. Patients with hypersensitivity of the stomach are recommended to take the drug with meals.

The dose depends on the age and body weight of the child.

For fever and pain, the maximum daily dose should not exceed 30 mg/kg body weight with intervals between doses of the drug of 6-8 hours.

Do not exceed the indicated dose.

The duration of treatment is no more than 3 days.

If, when using the drug for 24 hours (in children aged 3-5 months) or within 3 days (in children aged 6 months and older), symptoms persist or worsen, you should stop treatment and consult a doctor.

For fever after immunization in children under 6 months of age, the drug is prescribed at a dose of 50 mg (2.5 ml); if necessary, after 6 hours the drug can be re-administered at the same dose.

Do not use more than 100 mg (5 ml) within 24 hours.

Rules for using a measuring syringe

The suspension should be shaken thoroughly before use.

For precise dosing of the suspension, a measuring syringe is included with the bottle. 5 ml of the drug contains 100 mg of ibuprofen or 20 mg of ibuprofen in 1 ml.

1. Insert the syringe tightly into the neck of the bottle.

2. Turn the bottle upside down and smoothly pull the plunger down, drawing the suspension into the syringe to the desired mark.

3. Return the bottle to its original position and remove the syringe, carefully turning it.

4. Place the syringe in the child’s mouth and slowly press the plunger, smoothly releasing the suspension.

After use, rinse the syringe in warm water and dry it out of the reach of the child.

The risk of side effects can be minimized if the drug is taken in a short course, at the minimum effective dose required to eliminate symptoms.

Side effects are predominantly dose-dependent. The following adverse reactions were observed with short-term use of ibuprofen in doses not exceeding 1200 mg/day. When treating chronic conditions and with long-term use, other adverse reactions may occur.

The incidence of adverse reactions was assessed based on the following criteria: very often (≥1/10), often (from ≥1/100 to <1/10), infrequently (from ≥1/1000 to <1/100), rarely ( from ≥1/to <1/1000), very rare (<1/10,000), frequency unknown (no data available to estimate frequency).

From the hematopoietic system: very rarely - hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial oral ulcers, flu-like symptoms, severe weakness, nosebleeds and subcutaneous hemorrhages, bleeding and bruising of unknown etiology.

From the immune system: infrequently - hypersensitivity reactions (nonspecific allergic reactions and anaphylactic reactions), reactions from the respiratory tract (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (itching, urticaria, purpura , Quincke's edema, exfoliative and bullous dermatoses, including toxic epidermal necrolysis, Lyell's syndrome, Stevens-Johnson syndrome, erythema multiforme), allergic rhinitis, eosinophilia; very rarely - severe hypersensitivity reactions, incl. swelling of the face, tongue and larynx, shortness of breath, tachycardia, arterial hypotension (anaphylaxis, Quincke's edema or severe anaphylactic shock).

From the gastrointestinal tract: infrequently - abdominal pain, nausea, dyspepsia; rarely - diarrhea, flatulence, constipation, vomiting; very rarely - peptic ulcer, perforation or gastrointestinal bleeding, melena, hematemesis, ulcerative stomatitis, gastritis; frequency unknown - exacerbation of ulcerative colitis and Crohn's disease.

From the liver and biliary tract: very rarely - liver dysfunction.

From the urinary system: very rarely - acute renal failure (compensated and decompensated), especially with long-term use, in combination with an increase in the concentration of urea in the blood plasma and the appearance of edema, papillary necrosis.

From the nervous system: infrequently - headache; very rarely - aseptic meningitis (in patients with autoimmune diseases).

From the cardiovascular system: frequency unknown - heart failure, peripheral edema, with long-term use there is an increased risk of thrombotic complications (for example, myocardial infarction, stroke), increased blood pressure.

From the respiratory system: frequency unknown - bronchial asthma, bronchospasm, shortness of breath.

Other: very rarely - swelling, incl. peripheral.

Laboratory parameters: hematocrit or hemoglobin may decrease, bleeding time may increase, plasma glucose concentration may decrease, QC may decrease; plasma creatinine concentration may increase; hepatic transaminase activity may increase.

If side effects occur, you should stop taking the drug and consult a doctor.

In children, overdose symptoms may occur after taking a dose exceeding 400 mg/kg body weight. In adults, the dose-dependent effect of overdose is less pronounced. T 1/2 of the drug in case of overdose is 1.5-3 hours.

Symptoms: nausea, vomiting, epigastric pain or, less commonly, diarrhea, tinnitus, headache and gastrointestinal bleeding. In more severe cases, manifestations from the central nervous system are observed: drowsiness, rarely - agitation, convulsions, disorientation, coma. In cases of severe poisoning, metabolic acidosis and an increase in prothrombin time, renal failure, liver tissue damage, decreased blood pressure, respiratory depression and cyanosis may develop. In patients with bronchial asthma, exacerbation of this disease is possible.

Treatment: symptomatic, with mandatory maintenance of airway patency, monitoring of ECG and vital signs until the patient’s condition is normalized. Oral use of activated charcoal or gastric lavage is recommended within 1 hour after taking a potentially toxic dose of ibuprofen. If ibuprofen has already been absorbed, an alkaline drink may be prescribed in order to eliminate the acidic derivative of ibuprofen by the kidneys, forced diuresis. Frequent or prolonged seizures should be treated with IV diazepam or lorazepam. When bronchial asthma worsens, the use of bronchodilators is recommended.

The simultaneous use of ibuprofen with the drugs listed below should be avoided.

Acetylsalicylic acid: with the exception of acetylsalicylic acid in low doses (no more than 75 mg/day) prescribed by a doctor, since combined use may increase the risk of side effects. With simultaneous use, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (an increase in the incidence of acute coronary insufficiency in patients receiving acetylsalicylic acid in small doses as an antiplatelet agent is possible after starting ibuprofen).

Other NSAIDs, including selective COX-2 inhibitors: The simultaneous use of two or more drugs from the NSAID group should be avoided due to a possible increased risk of side effects.

Use with caution concomitantly with the following medications.

Anticoagulants and thrombolytic drugs: NSAIDs may enhance the effect of anticoagulants, in particular warfarin and thrombolytic drugs.

Antihypertensive drugs (ACE inhibitors and angiotensin II receptor antagonists) and diuretics: NSAIDs may reduce the effectiveness of drugs in these groups. Diuretics and ACE inhibitors may increase the nephrotoxicity of NSAIDs.

GCS: increased risk of gastrointestinal ulcers and gastrointestinal bleeding.

Antiplatelet agents and selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding.

Cardiac glycosides: simultaneous administration of NSAIDs and cardiac glycosides can lead to worsening heart failure, a decrease in glomerular filtration rate and an increase in the concentration of cardiac glycosides in the blood plasma.

Lithium preparations: there is evidence of the likelihood of an increase in the concentration of lithium in the blood plasma during the use of NSAIDs.

Methotrexate: there is evidence of the likelihood of an increase in the concentration of methotrexate in the blood plasma during the use of NSAIDs.

Cyclosporine: increased risk of nephrotoxicity when NSAIDs are administered concomitantly with cyclosporine.

Mifepristone: NSAIDs should be started no earlier than 8 to 12 days after taking mifepristone, as NSAIDs may reduce the effectiveness of mifepristone.

Tacrolimus: When NSAIDs and tacrolimus are coadministered, the risk of nephrotoxicity may increase.

Zidovudine: Concomitant use of NSAIDs and zidovudine may result in increased hematotoxicity. There is evidence of an increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia who received concomitant treatment with zidovudine and ibuprofen.

Quinolone antibiotics: In patients receiving concomitant treatment with NSAIDs and quinolone antibiotics, the risk of seizures may be increased.

It is recommended to take the drug for the shortest possible course and in the minimum effective dose necessary to eliminate symptoms.

During long-term treatment, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary.

When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a complete blood count (hemoglobin determination), and a stool test for occult blood.

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

During the treatment period, ethanol intake is not recommended.

The drug is contraindicated in patients with fructose intolerance, because contains maltitol.

Nurofen for children can be used for children with diabetes mellitus, because. the drug does not contain sugar.

Does not contain dyes.

Patients with renal failure should consult a doctor before using the drug, as there is a risk of deterioration in the functional state of the kidneys.

Patients with arterial hypertension, incl. history, and/or chronic heart failure, you should consult your doctor before using the drug, since the drug may cause fluid retention, increased blood pressure and edema.

Impact on the ability to drive vehicles and operate machinery

Patients who experience dizziness, drowsiness, lethargy, or blurred vision while taking ibuprofen should avoid driving or operating machinery.

The use of the drug is contraindicated in the third trimester of pregnancy. Before using the drug in the first and second trimesters of pregnancy or during breastfeeding, you should consult your doctor. There is evidence that ibuprofen can pass into breast milk in small quantities without any adverse effects on the health of the nursing infant.

Contraindicated in severe renal failure (creatinine clearance <30 ml/min).

Caution should be exercised when prescribing a drug for renal failure, incl. for dehydration (KKml/min), fluid retention and edema.

Contraindicated in severe liver failure or active liver disease.

Use with caution in case of liver failure.

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life: 3 years.

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Nurofen for children - official instructions for use

on the medical use of the drug NUROFEN FOR CHILDREN

Trade name: NUROFEN® FOR CHILDREN

Registration number: P No/01

International nonproprietary name (INN) ibuprofen

Dosage form: oral suspension [orange, strawberry]

Description: a suspension of white or almost white color, syrupy consistency with a characteristic orange or strawberry odor.

5 ml of Nurofen® suspension for children contains 100 mg of ibuprofen (active ingredient) and excipients: maltitol syrup, water, glycerol, citric acid, sodium citrate, sodium chloride, sodium saccharinate, orange flavor 2M16014 or strawberry flavor E, xanthan gum, polysorbate 80, domiphene bromide.

Pharmacotherapeutic group non-steroidal anti-inflammatory drug.

It has analgesic, anti-inflammatory and antipyretic effects. The mechanism of action of ibuprofen is due to inhibition of the biosynthesis of prostaglandins - mediators of pain and inflammation. The effect of the drug lasts up to 8 hours.

Nurofen" for children is used from 3 months of life to 12 years as an antipyretic for acute respiratory diseases, influenza, childhood infections, post-vaccination reactions and other infectious and inflammatory diseases accompanied by an increase in body temperature. The drug is used as an analgesic for pain of mild or moderate intensity, including: headaches and toothaches, migraines, neuralgia, pain in the ears and throat, pain with sprains and other types of pain.

Your doctor may also recommend this drug for other indications (in this case, follow your doctor’s recommendations on dosage and dosage regimen).

Nurofen® for children should not be used if:

  • hypersensitivity to ibuprofen, acetylsalicylic acid or other NSAIDs, as well as to other components of the drug;
  • bronchial asthma, urticaria, rhinitis, provoked by taking acetylsalicylic acid (salicylates) or other NSAIDs;
  • if the child has an ulcerative lesion of the gastrointestinal tract;
  • active gastrointestinal bleeding
  • for inflammatory bowel diseases;
  • with confirmed hypokalemia;
  • blood diseases: hypocoagulation, leukopenia, hemophilia;
  • renal and/or liver failure;
  • hearing loss PRECAUTIONS You should consult a doctor before giving your child Nurofen® for children if the child:
  • takes other painkillers;
  • has a history of: peptic ulcer, gastritis, ulcerative colitis, gastrointestinal bleeding;
  • suffers from liver or kidney disease;
  • if H. pylori is present
  • takes indirect anticoagulants (drugs for oral administration that reduce blood clotting), drugs to lower blood pressure, glucocorticosteroids, antiplatelet agents, diuretics (drugs to increase urination), lithium drugs, methotrexate;
  • suffers from bronchial asthma and urticaria. METHOD OF APPLICATIONNurofen® for children is a drug specially designed for children. Read the instructions carefully before using the drug. The drug is taken orally. Shake the bottle thoroughly before use. To accurately measure the dose of the drug, a convenient measuring syringe is included. 5 ml of the drug contains 100 mg of ibuprofen. USING A MEASURING SYRINGE:
    1. Insert the syringe tightly into the neck of the bottle.

    2. Shake the suspension well.

    3. Turn the bottle upside down and smoothly pull the plunger down, drawing the suspension into the syringe to the desired level.

    4. Return the bottle to its original position and remove the syringe, carefully turning it.

    5. Place the syringe in the child’s mouth and slowly press the plunger, smoothly releasing the suspension. After use, rinse the syringe in warm water and dry it out of the reach of the child. Fever (Heat) and pain:

    The dosage for children depends on the age and body weight of the child. A single dose is 5-10 mg/kg of the child’s body weight 3-4 times a day. The maximum daily dose should not exceed 30 mg per kg of body weight of the child per day. Children aged 3-6 months (child weight more than 5 kg): 2.5 ml 3 times within 24 hours, no more than 150 mg per day. Children aged 6-12 months (average child weight 6-10 kg): 2.5 ml 3-4 times within 24 hours, no more than 200 mg per day. Children aged 1-3 years (average child weight kg): 5.0 ml 3 times within 24 hours, no more than 300 mg per day. Children aged 4-6 years (average child weight kg): 7.5 ml 3 times within 24 hours, no more than 450 mg per day. Children aged 7-9 years (average child weight kg): 10 ml 3 times within 24 hours, no more than 600 mg per day. Children aged one year (average child weight kg): 15 ml 3 times within 24 hours, no more than 900 mg per day. Warning: Do not exceed the indicated dose.

    Post-immunization fever: 2.5 ml syringe for children under 1 year of age, after 1 year, if necessary, another 2.5 ml syringe after 6 hours.

    INTERACTION WITH OTHER MEDICINES Simultaneous use of NUROFEN® FOR CHILDREN with anticoagulants may lead to an increase in their effect. Nurofen® for children increases the concentration of digoxin, phenytoin, methotrexate, lithium in the blood plasma when used simultaneously with these drugs. Using Nurofen® for children together with diuretics and antihypertensive drugs reduces their effectiveness. Increases the side effects of mineralocorticosteroids and glucocorticosteroids. SPECIAL INSTRUCTIONS Nurofen® for children can be used in children with diabetes mellitus, because the drug does not contain sugar. Does not contain dyes. RELEASE FORM Oral suspension [orange, strawberry] 100 mg/5 ml. Polyethylene terephthalate bottle with a low-density polyethylene or polypropylene cap and liner, containing 100 ml or 150 ml of suspension. Each bottle, complete with a dispenser syringe, is packaged in a cardboard box along with instructions for use. STORAGE CONDITIONS At a temperature not higher than 25°C. In a dry place. Keep out of the reach of children! SHELF LIFE: 3 years.

    Do not use a drug that has expired. HOLIDAY FROM PHARMACIES Without a prescription.

    Reckitt Benckiser Healthcare International Ltd. Thane Road, Nottingham, NG90 2DB, UK, manufactured by BSM Ltd, Thane Road, Nottingham, NG2 ZAA, UK. Representative in Russia/address for claims

    Reckitt Benckiser Healthcare LLC

    Russia, Moscow, Kozhevnicheskaya st., 14

    Source: http://medi.ru/instrukciya/nurofen-dlya-detej_7347/

    Nurofen for children: instructions for use

    Nurofen suspension is a drug belonging to the pharmacological group of non-steroidal anti-inflammatory drugs. It is used for children as an analgesic and antipyretic for elevated body temperature.

    Release form and composition

    Suspension for oral (inside) use Nurofen has a syrupy consistency, white color, and a characteristic orange or strawberry smell. The main active ingredient of the drug is ibuprofen, its content in 5 ml of suspension is 100 mg. It also includes auxiliary components, which include:

    • Lemon acid.
    • Xanthan gum.
    • Sodium saccharinate.
    • Maltitol syrup.
    • Glycerol.
    • Sodium citrate.
    • Domiphen bromide.
    • Sodium chloride.
    • Orange flavor (2M16014) or strawberry (500244E).
    • Purified water.

    Nurofen suspension is contained in a polyethylene terephthalate bottle of 100 or 150 ml. The cardboard pack contains 1 bottle with the appropriate volume of suspension, a special dispenser syringe, as well as instructions for use of the drug.

    pharmachologic effect

    The main active ingredient of the Nurofen suspension, ibuprofen, has an inhibitory effect on the enzyme cycloxygenase, which catalyzes the reaction of converting arachidonic acid into mediators of the inflammatory reaction, prostaglandins, which are responsible for the development of the inflammatory reaction in tissues, the appearance of pain, and an increase in body temperature. By reducing the concentration of prostaglandins, the analgesic, anti-inflammatory and antipyretic therapeutic effect of the Nurofen suspension is realized.

    Data on the rate of absorption, distribution, metabolism and excretion of the active substance Nurofen have not been provided to date.

    Indications for use

    Taking Nurofen suspension is indicated for a number of pathological processes that are accompanied by an increase in body temperature and the development of pain against the background of an inflammatory reaction:

    • Acute respiratory viral infection is a viral infection of the upper respiratory tract with the development of intoxication.
    • Influenza is a specific respiratory viral infection caused by the influenza virus, characterized by a moderate to severe course with severe intoxication.
    • Various childhood bacterial and viral infections accompanied by fever.
    • Post-vaccination reaction of the body, which is characterized by an increase in the child’s body temperature after vaccination.
    • Migraine is a paroxysmal headache of moderate intensity.
    • Symptomatic headache.
    • Toothache of moderate intensity.
    • Neuralgia is pain that develops as a result of aseptic (non-infectious) inflammation of the peripheral nerves.
    • Pain in the middle ear, throat, bone sinuses of the skull.
    • Post-traumatic or postoperative pain of various localizations.

    Nurofen suspension is a drug for symptomatic treatment, it helps to lower body temperature, reduce the inflammatory reaction and pain, it does not affect the course of the pathological process and its progression.

    Contraindications for use

    Taking Nurofen suspension is contraindicated in a number of pathological and physiological conditions, which include:

    • Individual intolerance and increased sensitivity of the body to the active substance or auxiliary components of the drug.
    • Hypersensitivity to other non-steroidal anti-inflammatory drugs (acetylsalicylic acid, paracetamol).
    • The presence of manifestations of the “aspirin triad” syndrome, which is characterized by bronchial asthma, allergic rhinitis, nasal polyposis, which is provoked by taking acetylsalicylic acid and other representatives of non-steroidal anti-inflammatory drugs.
    • Pathology of the gastrointestinal tract, which is characterized by the formation of defects in the mucous membrane (erosive gastritis, peptic ulcer of the stomach or duodenum), especially in the stage of clinical and laboratory exacerbation.
    • Active gastrointestinal bleeding of any location.
    • Inflammatory bowel pathology.
    • Pathology of the blood system - hemophilia or hypocoagulation (blood clotting disorder), leukopenia (decreased number of leukocytes in the blood).
    • Marked decrease in the functional activity of the kidneys or liver.
    • Decreased hearing acuity.

    Nurofen suspension should be taken with caution in case of pathology of the liver, kidneys, infection of the stomach with the bacterium Helicobacter pylori, taking indirect anticoagulants (drugs that reduce blood clotting) or other non-steroidal anti-inflammatory drugs, bronchial asthma and urticaria, suffered from a previous peptic ulcer of the stomach or duodenum. Before you start taking Nurofen suspension, you should make sure that there are no contraindications.

    Directions for use and doses

    Nurofen syrup is a drug developed specifically for use in children. It is applied orally 3-4 times a day, the volume is dosed using a special dispenser syringe. The dosage depends on the child’s body weight and age:

    • Age 3-6 months, weight more than 5 kg – 50 mg (2.5 ml), 3 times a day.
    • Age from six months to one year, weight 6-10 kg - 50 mg (2.5 ml), 3-4 times a day.
    • Age from 1 year to 3 years, weight – 100 mg (5 ml), 3 times a day.
    • Age 4-6 years, weight – 150 mg (7.5 ml), 3 times a day.
    • Age 7-9 years, weight – 200 mg (10 ml), 3 times a day.
    • Age, weightkg – 300 mg (15 ml), 3 times a day.

    It is not recommended to exceed the recommended age dosage of Nurofen suspension. The duration of use of the drug to reduce body temperature during fever should not exceed 3 days, to reduce the severity of pain - no more than 5 days. If the symptoms of the pathological process continue to persist, you should consult a doctor. Before taking the Nurofen suspension, you need to shake it, then place the dispenser syringe tightly on the neck of the bottle and draw the required volume of the suspension in a vertical position of the bottle. Then the contents of the dispenser syringe are slowly squeezed into the child’s oral cavity, pressing on the piston. After use, the dispenser syringe should be rinsed with warm water and dried.

    Side effects

    After taking the Nurofen suspension, it is rarely possible to develop negative reactions from various organs and systems:

    • Digestive system - nausea followed by vomiting, pain in the abdomen, with a predominant localization in its upper parts (epigastrium), diarrhea, erosive and ulcerative lesions of the mucous membrane of the structures of the upper parts of the digestive tract, gastrointestinal bleeding.
    • Nervous system – headache, periodic dizziness, insomnia, psychomotor agitation.
    • Cardiovascular system - increased systemic blood pressure (arterial hypertension), increased heart rate (tachycardia).
    • Urinary system - impaired functional activity of the kidneys, reactive inflammation of the bladder (cystitis).
    • Blood system and red bone marrow – decrease in the number of red blood cells (anemia), platelets (thrombocytopenia), leukocytes (leukopenia).
    • Allergic reactions - skin rash, itching, urticaria (characteristic rash and swelling of the skin, reminiscent of a nettle burn), angioedema (severe swelling of soft tissues with predominant localization in the face and external genitalia), severe necrotic skin lesions (Lyell's syndrome , Stevens-Johnson), bronchospasm (allergic narrowing of the lumen of the bronchi with the development of shortness of breath), anaphylactic shock (severe systemic allergic reaction, which is characterized by a pronounced decrease in systemic blood pressure and multiple organ failure).

    If side effects develop after taking Nurofen suspension, its use should be stopped and consult a doctor.

    special instructions

    Before starting to use Nurofen suspension for children, you should carefully read the instructions for the drug. There are a few special instructions that you need to pay attention to, these include:

    • Since the drug is used for children, it does not contain dyes as auxiliary components.
    • Nurofen suspension contains sugar, which should be taken into account when using it in children with diabetes.
    • The active substance of the drug can interact with drugs from other pharmacological groups, in particular with indirect anticoagulants, methotrexate, glucocorticoids, and weakens the therapeutic effect of diuretics (diuretics) and antihypertensive drugs. In cases of their use, you should warn your doctor.
    • The use of the drug in children under 3 months is prohibited.

    Nurofen suspension is sold in pharmacies as an over-the-counter drug. If you have any questions regarding its use, you should consult your doctor.

    Overdose

    If the recommended therapeutic dose of the Nurofen suspension is exceeded, abdominal pain, nausea, vomiting, tinnitus appear, metabolic acidosis may develop (a pH shift to the acidic side), impaired consciousness up to coma, blood pressure decreases, the rhythm and frequency of heart contractions is disturbed (arrhythmia). Treatment of overdose consists of gastric and intestinal lavage, taking intestinal sorbents (provided that no more than an hour has passed since taking the suspension), as well as symptomatic therapy.

    Analogues of Nurofen for children

    In terms of composition and therapeutic effect, the drugs Ibuprofen, Ibufen, and Advil are similar to the Nurofen suspension.

    Terms and conditions of storage

    The shelf life of Nurofen suspension is 3 years from the date of manufacture. The drug should be stored in a dry, dark place, out of reach of children, at an air temperature no higher than +25° C.

    Nurofen children's price

    The average cost of Nurofen suspension in Moscow pharmacies depends on its volume in the bottle:

    • Bottles with a volume of 100 ml - rubles.
    • Bottles with a volume of 150 ml - rubles.

    Source: http://bezboleznej.ru/nurofen-detskiy

    Nurofen for children

    Nurofen for children: instructions for use and reviews

    Latin name: Nurofen for Children

    ATX code: M01AE01

    Active ingredient: Ibuprofen (Ibuprofen)

    Manufacturer: Reckitt Benckiser Healthcare International Ltd. (Great Britain)

    Update of description and photo: 11/15/2017

    Prices in pharmacies: from 99 rub.

    Nurofen for children is an NSAID (non-steroidal anti-inflammatory drug) used in pediatric practice.

    Release form and composition

    Dosage forms of Nurofen for children:

    • film-coated tablets: biconvex, round in shape, on one side the inscription Nurofen is printed in black, the shell and core in the cross section are white to almost white (6, 8, 10 or 12 pcs. in blisters, 1 or 2 blisters in a cardboard pack; 10 or 12 pcs in blisters, 3 blisters in a cardboard pack; 12 pcs in blisters, 4 or 8 blisters in a cardboard pack);
    • oral suspension (orange/strawberry): a liquid of syrupy consistency, from white to almost white in color, with a characteristic orange/strawberry odor (100, 150 or 200 ml each in polyethylene terephthalate bottles, equipped with a dosing syringe, 1 set in a cardboard box );
    • rectal suppositories: torpedo-shaped, glossy, from white to almost white; It is allowed to have a funnel-shaped depression or an air rod on the cut (5 pieces in aluminum blisters, 2 blisters in a cardboard pack).

    Composition per 1 tablet:

    • active substance: ibuprofen – 200 mg;
    • auxiliary ingredients: sodium lauryl sulfate, sodium citrate dihydrate, croscarmellose sodium, stearic acid, colloidal silicon dioxide;
    • shell: carmellose sodium, acacia gum, titanium dioxide, sucrose, macrogol 6000, talc;
    • black ink Opacode S: shellac, black iron oxide dye (E172), propylene glycol and solvents that evaporate during the printing process (butanol, ethanol, isopropanol, purified water).

    Composition per 5 ml suspension:

    • active substance: ibuprofen – 100 mg;
    • auxiliary ingredients: maltitol syrup, glycerol, polysorbate 80, sodium saccharinate, sodium chloride, sodium citrate, citric acid, xanthan gum, orange flavor 2M16014/strawberryE, domiphene bromide, purified water.

    Composition for 1 suppository:

    • active substance: ibuprofen – 60 mg;
    • auxiliary ingredients: solid fats – vitepsol H15 and vitepsol W45.

    Pharmacological properties

    Pharmacodynamics

    The active ingredient of Nurofen for children is ibuprofen. Like other non-steroidal anti-inflammatory drugs, it specifically relieves pain symptoms and has an anti-inflammatory and antipyretic effect.

    Being a non-selective blocker, ibuprofen blocks cyclooxygenase 1 and 2 (COX-1 and COX-2), which inhibits the synthesis of mediators of inflammation, pain and hyperthermic reaction - prostaglandins. In addition, ibuprofen reversibly inhibits platelet aggregation.

    The drug has the most pronounced analgesic effect for pain of inflammatory origin; its effect lasts for 8 hours.

    Pharmacokinetics

    • absorption and distribution: ibuprofen is well absorbed from the gastrointestinal tract (gastrointestinal tract), quickly and almost completely absorbed into the systemic circulation. In blood plasma after administration on an empty stomach, the substance is detected after 15 minutes, and the maximum plasma concentration (Cmax ) is reached after 60 minutes. Taking the drug with food can increase the time to reach Cmax by up to 120 minutes. Up to 90% of ibuprofen binds to blood plasma proteins, as a result of which the substance, slowly penetrating into the joint cavities, lingers for a long time in the synovial fluid, providing it with concentrations higher than in plasma. According to a few studies, ibuprofen penetrates into breast milk in extremely low concentrations;
    • metabolism and excretion: up to 60% of the substance in the pharmacologically inactive R-form after absorption is slowly transformed into the active S-form; Ibuprofen is metabolized in the liver; excreted by the kidneys (only less than 1% unchanged), to a lesser extent - with bile. The half-life of the drug is 2 hours.

    Indications for use

    Nurofen for children, depending on the dosage form, is used to treat patients of different age groups: suppositories are prescribed to children from 3 months to 2 years, a suspension to children from 3 months to 12 years, tablets to children from 6 years of age and adult patients. Nurofen suppositories for children are also recommended to be used if for some reason it is impossible to take oral forms of the drug, or in case of vomiting.

    All forms of the drug are used as an analgesic to relieve pain of various origins: headache, dental, ear, sore throat, muscle, menstrual, joint, rheumatic, back pain, neuralgia, migraines and other pathological conditions accompanied by pain.

    As an antipyretic drug, Nurofen for children is recommended for the following infectious and inflammatory diseases and conditions accompanied by fever: acute respiratory infections (acute respiratory diseases), influenza, childhood and other infections, post-vaccination reactions.

    Nurofen for children is intended only for symptomatic therapy, pain relief and inflammation at the time of its use. The drug does not have a clinically significant effect on the progression of the disease.

    Contraindications

    Absolute contraindications to the use of Nurofen for children in any of the release forms:

    • erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, including ulcerative colitis, peptic ulcer, exacerbation of gastric and duodenal ulcers, Crohn's disease (including history data);
    • severe arterial hypertension;
    • period after CABG (coronary artery bypass grafting);
    • decompensated heart failure;
    • syndrome of complete or incomplete intolerance to aspirin (urticaria, polyps of the nasal mucosa, rhinosinusitis, bronchial asthma) and/or other NSAIDs;
    • blood diseases (hemophilia, other coagulation disorders, hemorrhagic diathesis, glucose-6-phosphate dehydrogenase deficiency, hypocoagulation);
    • severe liver dysfunction;
    • severe renal impairment with creatinine clearance (CC) <30 ml/min;
    • bleeding (intracranial, from the gastrointestinal tract, etc.);
    • III trimester of pregnancy;
    • increased individual sensitivity to the active substance or any other components of the drug.

    Additional contraindications for tablets:

    • diseases of the optic nerve (scotoma, amblyopia, color vision impairment);
    • hearing loss, vestibular system disorder;
    • breast-feeding;
    • age up to 6 years.

    Additional contraindications for the suspension:

    • fructose intolerance;
    • confirmed hyperkalemia;
    • child weight up to 5 kg.

    Additional contraindications for suppositories:

    • proctitis;
    • confirmed hyperkalemia;
    • child weight up to 6 kg.

    Relative contraindications for the use of Nurofen for children (caution is required): simultaneous use with other NSAIDs, a history of gastric ulcers, ulcerative bleeding from the gastrointestinal tract, enteritis, gastritis, colitis, Helicobacter pylori infection, ulcerative colitis; bronchial asthma or allergic diseases in the acute stage, or a history of such (probably the development of bronchospasm), severe somatic diseases, systemic lupus erythematosus or mixed connective tissue disease, so-called. Sharp's syndrome (increases the likelihood of aseptic meningitis), renal failure, including dehydration (with creatinine clearance 30–60 ml/min), fluid retention and edema; liver failure, arterial hypertension/heart failure, diabetes mellitus, cerebrovascular diseases, hyperlipidemia/dyslipidemia, peripheral arterial disease, blood diseases of unknown etiology (anemia, leukopenia), concomitant use with other drugs that can increase the likelihood of ulceration or bleeding, and specifically with GCS (glucocorticosteroids) for oral administration (including prednisolone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including fluoxetine, paroxetine, citalopram, sertraline), antiplatelet agents [including acetylsalicylic acid (ASA) and clopidogrel]; I and II trimesters of pregnancy, old age; breastfeeding period - for suspension and suppositories; children aged 6 to 12 years – for tablets.

    Instructions for use of Nurofen for children: method and dosage

    Film-coated tablets

    The tablets are taken orally, after meals, with water.

    The recommended dosage of Nurofen for children over 12 years of age and adults, unless otherwise prescribed by a doctor: 200 mg (1 tablet) 3-4 times a day. If it is necessary to achieve a faster therapeutic effect for adult patients, the dose can be increased to 400 mg (2 tablets) 3 times a day.

    Children aged 6 to 12 years, weighing more than 20 kg, are recommended to take 1 tablet up to 4 times a day.

    The interval between doses of the drug should not be less than 6 hours.

    The maximum daily dose is 1200 mg (6 tablets).

    If symptoms of the disease persist after taking the tablets for 2-3 days, you must interrupt therapy and consult a doctor.

    Oral suspension

    The suspension is intended for oral use. In case of increased sensitivity of the gastrointestinal tract, it is recommended to combine the drug with food. Before use, the bottle of suspension should be shaken thoroughly.

    The maximum daily dose for the treatment of fever and pain should not be more than 30 mg/kg of the child’s weight, and the intervals between doses should be less than 6–8 hours.

    Recommended dosage of Nurofen for children depending on the age and weight of the child:

    • children from 3 to 6 months, weighing 5–7.6 kg: 50 mg (2.5 ml) 3 times a day; daily dose – 150 mg (7.5 ml);
    • children from 6 to 12 months, weighing 7.7–9 kg: 50 mg (2.5 ml) 3–4 times a day; daily dose – 200 mg (10 ml);
    • children from 1 year to 3 years, weighing 10–16 kg: 100 mg (5 ml) 3 times a day; daily dose – 300 mg (15 ml);
    • children from 4 to 6 years old, weighing 17–20 kg: 150 mg (7.5 ml) 3 times a day; daily dose – 450 mg (22.5 ml);
    • children from 7 to 9 years old, weighing 21–30 kg: 200 mg (10 ml) 3 times a day; daily dose – 600 mg (30 ml);
    • children from 10 to 12 years old, weighing 31–40 kg: 300 mg (15 ml) 3 times a day; daily dose – 900 mg (45 ml).

    The duration of therapy should not be more than 3 days. The indicated dose should not be exceeded.

    If symptoms of the disease persist after taking the suspension for 24 hours in children aged 3–5 months, or three days in children aged six months and older, or if they intensify, treatment should be stopped and consult a doctor.

    To relieve fever after immunization, children under six months of age are given a single dose of ibuprofen - 50 mg (2.5 ml of suspension); if necessary, after 6 hours you can prescribe a second dose at the same dose.

    The maximum daily dose of Nurofen for children is 100 mg (5 ml).

    The exact dose of the suspension is measured using a measuring syringe supplied with the bottle (1 ml of suspension contains 20 mg of ibuprofen, respectively, 5 ml - 100 mg).

    Rules for using a measuring syringe:

    1. The syringe is tightly inserted into the neck of the bottle.
    2. The bottle with the inserted syringe is turned upside down, the piston is smoothly pulled down, drawing the suspension to the required level.
    3. Return the bottle to its original position, then carefully turn and remove the syringe.
    4. Place the syringe in the child’s oral cavity, slowly press the plunger, smoothly releasing the suspension.
    5. After the procedure, rinse the syringe with warm water and dry it out of the reach of children.

    Rectal suppositories

    Nurofen suppositories for children are intended for rectal use.

    When treating fever and pain, the dose is calculated based on the child’s age and weight. The maximum daily dose should not be more than 30 mg/kg of the child’s weight, and the intervals between doses should be less than 6–8 hours.

    Recommended dose of the drug depending on the age and weight of the child:

    • children from 3 to 9 months, weighing 6–8 kg: 1 suppository (60 mg) up to 3 times a day; maximum daily dose – 180 mg;
    • children from 9 to 24 months, weighing 8–12 kg: 1 suppository (60 mg) up to 4 times a day; the maximum daily dose is 240 mg.

    The duration of therapy should not be more than 3 days. The indicated dose should not be exceeded.

    If symptoms of the disease persist after using suppositories for 24 hours in children aged 3–5 months, or 3 days in children aged six months and older, or if they intensify, treatment should be stopped and consult a doctor.

    To relieve fever after immunization, children under one year of age are prescribed a single administration of 1 suppository (60 mg); if necessary, after 6 hours you can re-administer the drug in the same dose. More than 2 pcs. (120 mg) should not be used within 24 hours.

    Side effects

    The likelihood of side effects is reduced to a minimum if you follow the dosage regimen of Nurofen for children and use ibuprofen for the shortest possible course in the minimum effective dose necessary to eliminate the symptoms of the disease.

    Side effects recorded with short-term use of ibuprofen in doses not exceeding 1200 mg per day are predominantly dose-dependent (rating scale: very often - ≥ 0.1; often - ≥ 0.01 and < 0.1; infrequently - ≥ 0.001 and < 0.01; rarely - ≥ 0.0001 and < 0.001; extremely rare - < 0.0001; with unknown frequency - insufficient data to make an assessment):

    • hematopoietic system: extremely rarely - hematopoietic disorders (leukopenia, anemia, aplastic/hemolytic anemia, pancytopenia, thrombocytopenia, agranulocytosis; the primary signs of such disorders are sore throat, fever, superficial ulcers in the oral cavity, severe weakness, flu-like symptoms, subcutaneous hemorrhages, nosebleeds, bleeding and bruising of unknown origin);
    • immune system: uncommon - nonspecific allergic and anaphylactic reactions, respiratory tract responses (bronchial asthma, including its exacerbation, shortness of breath, dyspnea, bronchospasm), skin reactions (urticaria, itching, purpura, Quincke's edema, exfoliative/bullous dermatoses, including toxic epidermal necrolysis, Stevens-Johnson syndrome, Lyell's syndrome, erythema multiforme), eosinophilia, allergic rhinitis; extremely rarely - severe hypersensitivity reactions (including swelling of the tongue, larynx and face), shortness of breath, arterial hypotension, tachycardia (anaphylaxis, Quincke's edema or severe anaphylactic shock);
    • Gastrointestinal tract: uncommon – nausea, abdominal pain, dyspepsia; rarely – flatulence, constipation/diarrhea, vomiting; extremely rarely - melena, peptic ulcer, gastritis, hematemesis, perforation or gastrointestinal bleeding, ulcerative stomatitis; with unknown frequency - exacerbation of ulcerative colitis, Crohn's disease;
    • liver and biliary tract: extremely rarely - liver function disorders;
    • urinary system: extremely rarely - acute renal failure (compensated/decompensated), especially in the case of long-term use, in combination with an increase in urea content in the blood plasma and swelling, papillary necrosis;
    • nervous system: infrequently – headache; extremely rarely - aseptic meningitis (mainly in patients with autoimmune diseases);
    • cardiovascular system: with unknown frequency - peripheral edema, heart failure, increased blood pressure; with long-term use, the likelihood of thrombotic complications (myocardial infarction, stroke) increases;
    • respiratory system: with unknown frequency - bronchospasm, shortness of breath, bronchial asthma;
    • other reactions: extremely rarely - edema, including peripheral;
    • laboratory test results: hematocrit/hemoglobin, plasma glucose concentration, CC (creatinine clearance) may decrease; plasma creatinine concentration, liver enzyme activity and bleeding time increase.

    If any side effects occur, drug therapy should be stopped and consultation with a specialist should be sought.

    Due to the treatment of chronic conditions and during long-term treatment, other adverse reactions may occur.

    Overdose

    In childhood, an overdose may occur after taking ibuprofen in a dose exceeding 400 mg/kg of the child’s weight. The dose-dependent effect of the condition in adult patients is less pronounced. T 1/2 of the substance from the body is from 1.5 to 3 hours.

    Symptoms of an ibuprofen overdose are nausea/vomiting, pain in the epigastric region, and less commonly, diarrhea, headache, tinnitus, and gastrointestinal bleeding. In more severe cases, reactions from the central nervous system such as drowsiness are observed, in rare cases - convulsions, agitation, disorientation, coma. Due to severe poisoning, damage to the liver parenchyma, decreased blood pressure, cyanosis and respiratory depression, increased prothrombin time, development of metabolic acidosis, and renal failure are possible. With bronchial asthma, its exacerbation is possible.

    Treatment is recommended to be symptomatic, under monitoring of airway patency, electrocardiogram data and basic vital signs of the patient, until his condition is normalized. Within an hour after taking a potentially dangerous dose of ibuprofen, it is necessary to give the patient activated charcoal or perform a gastric lavage. When ibuprofen is completely absorbed into the systemic circulation, the patient needs an alkaline drink to eliminate the acidic derivative of ibuprofen by the kidneys and forced diuresis. Frequent and/or prolonged seizures are treated with intravenous diazepam or lorazepam. Worsening of bronchial asthma requires the use of bronchodilators.

    special instructions

    Nurofen for children should be used for the shortest possible course, in the smallest dose effective to eliminate symptoms.

    During long-term therapy, it is necessary to monitor the peripheral blood picture and the functional state of the liver and kidneys.

    If symptoms of gastropathy appear, careful monitoring of the patient's condition is necessary, including esophagogastroduodenoscopy, a complete blood count (including hemoglobin determination) and a stool test for occult blood.

    On the eve of the determination of 17-ketosteroids, 48 ​​hours before the study, the use of ibuprofen is stopped for a while.

    Taking ethanol during drug therapy should be avoided.

    Nurofen for children in the form of an oral suspension is contraindicated in patients with fructose intolerance, since it contains maltitol.

    The suspension is approved for use in children with diabetes because it does not contain sugar.

    Nurofen for children does not contain dyes.

    In case of renal failure, before using the drug, you should consult a doctor because of the likelihood of deterioration in the functional state of the kidneys due to the use of ibuprofen.

    The drug can cause fluid retention in the body, swelling and increased blood pressure, therefore, in case of arterial hypertension (including a history) and chronic heart failure, you should consult a specialist before using the drug.

    Impact on the ability to drive vehicles and complex mechanisms

    If adverse reactions such as drowsiness, lethargy, dizziness, blurred vision occur as a result of taking ibuprofen, you should avoid driving a vehicle or operating complex machinery during the course of therapy.

    Use during pregnancy and lactation

    The use of Nurofen for children during the third trimester is contraindicated. The drug should be used in the first and second trimesters or during lactation (breastfeeding) only after a doctor's permission.

    There is evidence that ibuprofen can pass into breast milk in small quantities without clinically significant adverse effects on the health of the nursing baby.

    Use in childhood

    According to the instructions, Nurofen for children is used in childhood according to indications.

    Suspensions and suppositories are contraindicated for children under 3 months of age, tablets for children under 6 years of age; The child’s weight must be more than 5 kg for suspensions, more than 6 kg for suppositories, more than 20 kg for tablets.

    For impaired renal function

    The use of the drug is contraindicated in severe renal failure with CC less than 30 ml/min. Ibuprofen is prescribed with caution in case of renal failure with CC 30–60 ml/min, including with dehydration, fluid retention and swelling.

    For liver dysfunction

    The use of Nurofen is contraindicated for children with severe liver failure and active liver disease.

    Use in old age

    Elderly patients should prescribe the drug with caution.

    Drug interactions

    Medicines that should be avoided in combination with ibuprofen:
    • ASA (except for low doses, not more than 75 mg/day, prescribed by a doctor): combined use may increase the likelihood of adverse reactions; ibuprofen inhibits the anti-inflammatory and antiplatelet effect of aspirin (the incidence of acute coronary insufficiency may increase in patients receiving small doses of ASA as an antiplatelet agent after starting ibuprofen);
    • other NSAIDs, including selective COX-2 inhibitors: it is not recommended to use two or more drugs from the NSAID group at the same time due to a possible increase in the risk of side effects.

    Ibuprofen should be used with caution concomitantly with the following medications/drugs:

    • anticoagulants (including warfarin) and thrombolytics: their effectiveness may be enhanced;
    • antihypertensive drugs [ACE inhibitors (angiotensin-converting enzyme) and angiotensin II receptor antagonists], diuretics: their effectiveness may decrease and a response increase in the nephrotoxicity of ibuprofen;
    • GCS: increases the likelihood of ulceration of the gastrointestinal mucosa and gastrointestinal bleeding;
    • cardiac glycosides: possible worsening of heart failure, decreased glomerular filtration rate and increased plasma concentration of cardiac glycosides;
    • antiplatelet drugs and SSRIs (selective serotonin reuptake inhibitors): increases the risk of gastrointestinal bleeding;
    • lithium preparations, methotrexate: an increase in the plasma concentration of these drugs is likely;
    • mifepristone: since NSAIDs may reduce the effectiveness of mifepristone, their use should be started 8-12 days (not earlier) after using mifepristone;
    • cyclosporine, tacrolimus: increases the risk of nephrotoxicity;
    • zidovudine: possible increase in hematotoxicity; it is reliably known about the increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia who received complex therapy with zidovudine and ibuprofen;
    • quinolone antibiotics: increases the risk of seizures.

    Analogs

    Analogs of Nurofen for children are: Advil, Bonifen, Brufen SR, Deblok, Dolgit, Ibuprofen for children, Ibuprofen-Akrikhin, Ibuprofen-Hemofarm, Ibufen, Maxicold, Faspik, MIG 400, MIG, Nurofen, Nurofen forte, Nurofen Express, Nebolin, Sedalgin SPRINT, Solpaflex, Pedea, etc.

    Terms and conditions of storage

    Store out of reach of children at temperatures up to 25 °C. Protect tablets and suppositories from moisture.

    Shelf life: tablets, suspension – 3 years, suppositories – 2 years.

    Conditions for dispensing from pharmacies

    Available without a prescription.

    Reviews of Nurofen for children

    Judging by the number of reviews, Nurofen for children is popular not only with parents and attending physicians, but also with young patients. Those who have taken the suspension note its pleasant taste. Other advantages of the drug include its high efficiency, safety and ease of use. The drug is also attractive for its low age threshold; it can be used in children from 3 months of age.

    The disadvantages include the presence of contraindications, the appearance of allergic reactions with prolonged use, and it is also noted that in some children the drug does not reduce high fever immediately, but gradually.

    Price for Nurofen for children in pharmacies

    Approximate price of Nurofen for children, depending on the form of release and packaging: tablets of 8 pcs. per package – 97 rubles, suppositories 10 pcs. in a package - 99 rubles, suspension with orange/strawberry flavor, 150 ml in a bottle - 175 rubles.

    Nurofen for children 60 mg No. 10 suppositories

    Nurofen for children suppositories (candles) 60 mg 10 pcs.

    Nurofen for children tablets 200 mg n8 from 6 years

    Nurofen for children suppositories 60 mg n10

    Nurofen for children suspension 100 mg/5 ml 100 ml strawberry

    Nurofen for children suspension strawberry 100 mg/5 ml 100 ml

    Nurofen for children suspension 100 mg/5 ml 150 ml strawberry

    Education: First Moscow State Medical University named after I.M. Sechenov, specialty "General Medicine".

    Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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    Source: http://www.neboleem.net/nurofen-dlja-detej.php