Mometasone is a hormonal drug

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Mometasone

Instructions for use:

Mometasone is an anti-inflammatory drug intended for local external use. The active ingredient of this drug is mometasone furoate. In addition to a pronounced anti-inflammatory effect, it also has a vasoconstrictor, antipruritic and antiexudative effect on the body.

Table of contents:

pharmachologic effect

Mometasone furoate is part of a group of glucocorticosteroids that can only be used for topical use. The drug exhibits pronounced antipruritic, anti-inflammatory, antiallergic and antiexudative effects.

Even with long-term use, this drug does not suppress the functioning of the hypothalamic-pituitary-adrenal system. The clinical effect of the drug begins to appear within 12 hours after the start of treatment.

Release form

The drug is produced by the manufacturer in the form of Mometasone lotion, cream, ointment and nasal spray.

Indications

According to the instructions, mometasone furoate in the form of a cream or ointment effectively relieves itching and inflammation in dermatoses that are treated with glucocorticosteroids: neurodermatitis, stasis dermatitis, solar, radiation, intertriginous and exfoliative dermatitis.

Also, according to the instructions, Mometasone is prescribed to adult patients and children over two years of age for atopic and seborrheic dermatitis, psoriasis, chronic eczema, lichen simplex chronicus, anogenital or senile itching, 1st degree burns, sunburn, insect bites, lichen planus and discoid red lupus.

Mometasone spray is used for the treatment and prevention of nasal polyposis, allergic rhinitis and exacerbations of sinusitis.

Mometasone in the form of a lotion is intended for treating the scalp.

Contraindications

Any form of the drug is not prescribed for the treatment of children under two years of age, with hypersensitivity to the active substance of the drug, as well as during pregnancy and lactation.

The instructions for Mometasone also note that the drug cannot be used if the integrity of the skin and mucous membranes is damaged.

Mometasone spray is contraindicated in case of herpes simplex, fungal, bacterial, tuberculosis or viral systemic infection. In addition, this form of the drug should not be used by patients who have recently undergone surgery or trauma to the nose.

Mometasone cream, lotion or ointment should not be applied to the face, as well as to the skin in the groin and axillary areas.

The drug is prescribed with caution during long-term systemic therapy with GCS.

Instructions for use (method and dosage)

Mometasone spray is used for intranasal inhalation. Before performing the first irrigation, 6-7 test presses should be performed (this procedure is recommended to be performed every time there is a break in therapy lasting at least two weeks).

Before irrigation, shake the Mometasone spray can thoroughly. With one press, about 100 mg of suspension containing 50 mcg of active substance is released from the bottle. For treatment and prevention, adult patients and children over 12 years of age are recommended to take 2 inhalations into each nostril once a day. The maximum daily dosage of the drug is 200 mcg.

When a therapeutic effect is achieved, the number of inhalations should be reduced to one irrigation in each nostril. If this does not happen, the dosage of the drug can be increased and up to 4 inhalations into each nostril. According to the instructions for Mometasone, the patient's condition usually improves in the first 12 hours after the procedure.

Children aged 2-11 years are given one inhalation into each nostril once a day. The total single dosage of the drug is 100 mcg.

For exacerbation of sinusitis, patients over 12 years of age are prescribed two inhalations of mometasone furoate twice a day into each nostril. If no improvement is observed, the dosage can be increased to 800 mcg (4 irrigations in each nostril twice a day). When the patient's condition improves, the dosage of the drug should be reduced.

Mometasone in the form of a cream or ointment is applied to the damaged area of ​​the skin once a day. In this case, the duration of the course of treatment is determined individually.

According to the instructions, Mometasone lotion is applied to the scalp once a day, rubbing it in until completely absorbed.

Overdose

Excessive and long-term use of mometasone furoate can lead to suppression of pituitary-adrenal function, which, in turn, provokes the development of secondary adrenal insufficiency. Also, with an overdose of the drug, hypercortisolism (including Cushing's disease) may occur.

When the above phenomena occur, appropriate symptomatic therapy is indicated. If necessary, electrolyte imbalance is corrected. In case of development of chronic toxic effects, gradual withdrawal of the drug is performed.

Side effects

External use of Mometasone can lead to local adverse reactions such as burning, itching, skin atrophy and rosacea. In some cases, the drug causes irritation and dryness of the skin, hypertrichosis, folliculitis, hypopigmentation, acne, prickly heat, perioral dermatitis, stretch marks, skin maceration, allergic contact dermatitis or secondary infection.

The likelihood of developing undesirable side reactions increases when occlusive dressings are applied with the drug. If any of the above effects occur, you should stop taking the drug.

Mometasone spray may cause headaches, nosebleeds, pharyngitis, sneezing, nasal irritation, burning in the nose, increased intraocular pressure, or perforation of the nasal septum.

special instructions

If local infectious lesions appear during treatment with Mometasone, the doctor will prescribe appropriate antifungal or antibacterial therapy. During the treatment of these complications, the drug should be suspended.

If the course of treatment with the drug continues for more than two weeks, and the patient’s condition does not improve, it is necessary to clarify the diagnosis.

When treating children over two years of age, Mometasone ointment and cream are used under the supervision of a physician. Due to the larger ratio of skin surface area to body weight compared to a similar value in adult patients, the risk of suppression of the functionality of the hypothalamic-pituitary-adrenal system in childhood is significantly higher than in adults. In addition, young patients are at increased risk of developing atrophic skin lesions and Cushing's disease. Mometasone should not be used to treat diaper dermatitis.

Cream and ointment are not recommended for use under waterproof underwear or occlusive dressings due to the high risk of systemic complications.

Drug interactions

Due to certain chemical properties of mometasone, furoate is incompatible with alkalis.

Conditions and shelf life

It is recommended to store mometasone at an air temperature no higher than +25 °C. If storage conditions are met, the shelf life of the drug will be 2 years.

The description posted on this page is a simplified version of the official version of the annotation for the drug. The information is provided for informational purposes only and does not constitute a guide for self-medication. Before using the medicine, you must consult a specialist and read the instructions approved by the manufacturer.

When using materials from the site, the active reference is obligatory.

The information presented on our website should not be used for self-diagnosis and treatment and cannot serve as a substitute for consultation with a doctor. We warn you about the presence of contraindications. Specialist consultation is required.

Source: http://dolgojit.net/mometazon.php

Nasonex: drug No. 1 for allergies and more

Our pharmacies are stocked with antiallergic drugs. The showcases are full of beautiful packaging, and TV screens and the pages of glossy magazines obsessively talk about happy allergy sufferers who don’t care about flowers and herbs after being treated with pills. But not a single advertising medium says how often tablet drugs are powerless against allergies. And the unaware sufferers, who have tried all the advertised medicines and continue to sneeze and sniffle, may never know that the most effective remedy remains unknown. We're talking about Nasonex, the drug of choice for moderate to severe allergies.

>> The site presents an extensive selection of medications for the treatment of sinusitis and other nasal diseases. Enjoy it for your health! <

What is Nasonex?

Nasonex is an original Belgian drug produced by the famous pharmaceutical corporation Schering Plow. In her laboratories, pharmacists created a fundamentally new medicine for allergies - an intranasal spray with the glucocorticoid mometasone. Yes, don’t be alarmed: the composition of Nasonex, beloved by many for its effectiveness and good tolerability, includes a hormonal drug - the glucocorticosteroid mometasone furoate.

How does he work?

Like all other corticosteroids, mometasone has two properties: it has a pronounced anti-inflammatory and antiallergic effect. The mechanism of the antiallergic activity of mometasone is based on its ability to stop the release of allergy mediators. But they are the ones who bear the main burden of responsibility for annoying sneezing and sniffling.

Mometasone furoate has gone through many comparative studies and has proven exceptional activity. Thus, it turned out that mometasone inhibits the release of allergy mediators 10 times more strongly than other corticosteroids beclomethasone, betamethasone, hydrocortisone and dexamethasone.

In addition, in tests involving the application of antigens (provocative substances that trigger an allergic reaction), the drug proved high anti-inflammatory activity.

Treatment with Nasonex: allergies, nasal polyps and sinusitis.

Allergy

We will no longer unfoundedly praise Nasonex. It is much more productive and revealing to turn to statistics and numbers.

Clinical studies have confirmed that within the first 12 hours after starting treatment with Nasonex, a pronounced effect is obtained by 28% of patients with allergic rhinitis (simply, allergic rhinitis). 36 hours after the start of therapy, allergy symptoms subsided in half of the patients.

Surprisingly, Nasonex nasal spray can also relieve ocular allergic symptoms: redness, itching and lacrimation.

Nasal polyps

Mometasone works great not only for allergies. Thus, in patients suffering from nasal polyps, treatment with Nasonex leads to noticeable clinical improvement. In particular, after a course of therapy, nasal congestion, traditional for nasal polyps, is greatly reduced, their size decreases, and even the sense of smell is restored.

And, of course, sinusitis

Nasonex is also used in the complex therapy of rhinosinusitis, including sinusitis.

The anti-inflammatory effect of mometasone can significantly alleviate the course of the disease. Treatment with mometasone has been clinically proven to reduce facial pain and sinus pressure, rhinorrhea and nasal congestion. Moreover, the effect in acute and chronic sinusitis is long-lasting, lasting for at least 15 days after the end of treatment.

Distribution Features

Yes, you say, it’s wonderful that Nasonex is so effective for diseases of the nasopharynx. But, however, it is not the safest drug - corticosteroid hormones. This is dangerous!

In fact, only the first sentence is true, the second is partly true, and the third is completely false. Indeed, Nasonex is a hormonal drug. And in fact, long-term use of oral corticosteroids is associated with a high risk of severe side effects. But intranasal drugs behave differently in the body.

It has been established that after intranasal spraying of mometasone, less than 1% of the active substance penetrates into the blood. Even if you were somehow miraculously able to swallow the medicine, it is practically not absorbed from the gastrointestinal tract due to very low absorption. Those trace amounts that are still absorbed are almost completely excreted in bile or urine.

Thus, the corticosteroid mometasone administered intranasally, that is, in the form of a nasal spray, does not act systemically. And, therefore, it cannot cause side effects. Therefore, Nasonex is one of the safest drugs for the common cold, despite the fact that it contains a real hormonal substance.

Indications for use

So, let's list the diseases for which mometasone spray is prescribed. Among them:

  • seasonal or year-round allergic rhinitis. Let us add that Nasonex is used both for the treatment of allergies and for prevention before the allergy season;
  • acute sinusitis (including acute sinusitis). Nasonex in such cases is only an integral part of complex treatment, often against the background of concomitant antibiotic therapy;
  • nasal polyps with active symptoms (nasal congestion and loss of smell).

Preparing the bottle for use

Nasonex is a dosed drug, so it is very important to correctly calibrate the bottle. Only after careful calibration, each press will release a strictly adjusted dose of mometasone furoate, amounting to 50 mcg per 100 mg of medicinal suspension. The calibration itself is quite simple.

Before the first use, you need to press the sprayer 10 times in succession. As a result of these simple steps, a standardized supply of mometasone furoate is established.

If you have not used Nasonex for two weeks or longer, a follow-up calibration is necessary. To do this, you need to press the sprayer twice - this is enough to resume the regular supply of the active substance.

Patients need to remember two more nuances:

  • firstly, Nasonex spray is a suspension in which the active substance is not dissolved, but is unevenly suspended in a solvent. Therefore, the bottle must be shaken before each use;
  • secondly, the nozzle on the bottle may become clogged - after all, we are dealing not with a solution, but with a suspension. If you notice that this has happened, you need to remove the plastic cap, and then the nozzle, which should be rinsed with warm water. After drying it thoroughly, you can put it in place and treat it with Nasonex.

It is strictly forbidden to clean a clogged nozzle with a needle (knitting needle, hairpin, etc.). This may cause the dispenser to break down and the dispenser to malfunction. As a result, the final dosage of Nasonex may not correspond to the 50 mcg we need.

How to take Nasonex: doses and frequency of use

Regardless of what disease you are treating, you need to take care of free nasal breathing before using the medicine. Clear your nose of mucus using a solution of sodium chloride, sea water and, if necessary, vasoconstrictor drops. Only after this can you begin treatment with Nasonex.

Allergic rhinitis

For allergies, Nasonex is prescribed to adults and children. The average dosage for patients over 12 years of age is 2 injections into each nasal passage once a day. As soon as signs of improvement appear, it makes sense to reduce the dosage by half - to one injection into each nasal passage per day.

If the standard initial dosage does not work enough, you can, on the contrary, increase it to the maximum. According to the instructions for use in such cases, the dose of Nasonex can be up to 4 injections into each nasal passage once a day. And, again, after improvement, the dose is reduced by half.

For children over 2 and under 12 years of age, one spray into each nasal passage once a day is sufficient.

Positive treatment results should not be expected earlier than 12 hours after the first dose of Nasonex spray. The drug begins to work at full strength only 48 hours after the start of therapy.

Acute sinusitis (sinusitis) and rhinosinusitis

For the treatment of acute sinusitis, Nasonex is used only in adults and children over 12 years of age. The initial dosage is two injections into each nasal passage twice a day. If necessary, the dose can be increased to four injections twice a day. As soon as the symptoms of the disease subside, the dosage is reduced by half.

Nasal polyps

For polyps in the nasal cavity, the drug is used only in patients over 18 years of age. The standard dosage in such cases is two injections into each nasal passage once a day.

When is Nasonex contraindicated?

There are only a few conditions in which intranasal mometasone should not be used. Nasonex and its analogues are strictly contraindicated if:

  • you have hypersensitivity to mometasone or the auxiliary components of Nasonex spray;
  • an active untreated infection progresses in the nasal cavity, affecting the mucous membrane. Glucocorticosteroids can suppress the healing of wounds resulting from injury, surgery, etc. Therefore, patients after surgery or trauma to the nasal cavity should avoid Nasonex or other drugs with steroids, for example, Avamys, until the nasal mucosa heals.

In all other cases, the drug is safe and approved for use (of course, within the age restrictions).

Side effects

Alas, in the process of using Nasonex spray, despite all its safety, sometimes side effects cannot be avoided. However, we hasten to reassure potential consumers: adverse events during therapy with intranasal mometasone are rather the exception to the rule.

Adults may experience:

  • nosebleeds, which can be either obvious or subtle and appear in the form of mucus or blood-stained clots;
  • pharyngitis - inflammation of the pharyngeal mucosa;
  • burning sensation in the nasal cavity;
  • irritation of the nasal mucosa.
  • Of all four undesirable effects, the most common is the first - nosebleeds. They may appear in 5% of patients taking Nasonex.

However, nosebleeds are usually short-lived, minor, and stop on their own. Note that when treating with other intranasal corticosteroids, the risk of bleeding is the same as when using Nasonex.

The likelihood of developing other side effects does not differ from the chances of getting them as a result of treatment with a dummy drug - a placebo.

When treating children, headache is added to the list of undesirable manifestations, which nevertheless develops extremely rarely and does not require discontinuation of Nasonex.

Nasonex during pregnancy: dangerous or not?

It is reliably known that when Nasonex is used intranasally, the medicine is not detected in the blood even by the most sensitive laboratory techniques. Theoretically, this indicates the complete safety of the drug for all groups of patients, including pregnant women.

However, the principles of prescribing drugs in obstetrics are based on clinical confirmation of safety in accordance with the requirements of evidence-based medicine.

To give the green light for the use of the drug in pregnant and lactating women, it is necessary to conduct clinical trials on these groups of patients and prove in practice that there is no effect on the fetus, the course of pregnancy or on the child (if breastfeeding).

For completely understandable ethical reasons, Schering Plow did not initiate such studies, so there is no official permission for the use of Nasonex during pregnancy and breastfeeding and probably will not be. And yet, in cases of severe allergies or extreme necessity, the drug is prescribed under the guise of “the benefit to the mother outweighs the risk to the fetus.”

Nasonex as part of complex treatment

Despite the fact that Nasonex is also used for inflammatory diseases of the nasal mucosa, including viral and bacterial rhinitis, adenoids and sinusitis, its main purpose is to counteract an allergic reaction. It gives the best results and tolerability specifically for allergies in adults and children. The world's leading allergists, along with scientists involved in clinical research, are unanimous on one thing.

Nasonex is the most effective modern drug for allergies, and pharmaceuticals do not yet know more effective and better remedies

However, unfortunately, he is not omnipotent. Depending on the severity of the disease, it can be used both as monotherapy and as part of complex treatment.

For mild allergies, as a rule, only intranasal mometasone is prescribed.

For allergies of moderate severity or ineffectiveness of monotherapy, an antihistamine is included in the treatment regimen. The instructions indicate that Nasonex does not interact with the popular antihistamine loratadine, and patient reviews confirm the good tolerability of this combination.

For severe allergies that do not respond to complex treatment, oral corticosteroids are used and plasmapheresis is often prescribed.

Replace the irreplaceable: Nasonex analogues

Nasonex is an original drug, and therefore not the most economical. Unfortunately, its price can hurt your pocket, so many patients seek to replace Nasonex with a cheaper analogue. And he is, however, the only one.

This is a drug from the Israeli company Teva Desrinit, which is of good quality at a fairly reasonable price.

Nasonex sinus

Consumers often ask a logical question: what is the difference between Nasonex and Nasonex sinus? It turns out that it's just a matter of price. Nasonex contains 120 doses, and Nasonex sinus, according to the instructions for use, contains only 60. Thanks to the release of a more economical form, the drug has become more accessible. This means that more Russians will be able to treat runny noses with Nasonex.

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What if the course of taking corticosteroids is completed, and the runny nose, stuffiness and sneezing gradually return? Should I resume taking it, or limit myself to vasoconstrictors? And if you resume taking it, after how long?

Source: http://gaimoriti.ru/medicamenty/nazoneks.html

Name: Mometasone Group: Hormones, their analogues and antihormonal drugs Adrenal cortex hormones Adrenal cortex hormones and their synthetic analogues

pharmachologic effect

Mometasone is a synthetic glucocorticosteroid for topical use. The drug has antiallergic, antiexudative, antipruritic and anti-inflammatory effects when used in doses at which there is no systemic effect. Mometasone inhibits the production of inflammatory mediators and also increases the production of lipomodulin, which is an inhibitor of phospholipase A. This helps block the release of arachidonic acid, therefore, the synthesis of arachidonic acid metabolic products - prostaglandins, cyclic endoperoxides - is inhibited.

Mometasone prevents the marginal accumulation of neutrophils, which reduces the production of lymphokines and inflammatory exudate, inhibits the movement of macrophages, leading to a decrease in the processes of granulation and infiltration. Inhibits the occurrence of immediate allergic reactions.

Mometasone has negligible bioavailability (≤0.1%). The degree of penetration of the active substance through the skin is determined by various factors (the integrity of the skin at the site of application, the composition of the drug). Studies conducted on volunteers have shown that about 0.4% of a dose of cream applied to intact skin is detected in the blood after 8 hours. Increased penetration of the drug through the skin can result from damage or inflammatory processes at the site of application.

Indications for use

Itching and inflammation in dermatoses that are amenable to GCS therapy; conditions with symptoms of hyperkeratosis (chronic eczema, psoriasis, seborrheic and atopic dermatitis) in adults and children over two years of age.

Mode of application

A thin layer of cream or ointment is applied to the affected area of ​​the skin once a day. The duration and regimen of treatment, as well as the required dosage form, are determined by the doctor in each specific case.

Side effects

External applications of the drug can lead to the following local side effects: itching, burning, rosacea, skin atrophy. In rare cases, local use of GCS can lead to the following side effects: folliculitis, irritation and dry skin, acne, hypertrichosis, perioral dermatitis, hypopigmentation, secondary infection, miliaria, stretch marks, contact allergic dermatitis. When using occlusive dressings, the likelihood of these side effects increases.

If during therapy with Mometasone changes appear on the skin at the site of application of the drug, treatment is stopped.

Contraindications

— Age up to 2 years;

- hypersensitivity to mometasone furoate, auxiliary components of the drug or other corticosteroids;

- Mometasone is also contraindicated in persons who have recently undergone trauma or surgery on the nose until postoperative wounds have completely healed.

Pregnancy

It is possible to use Mometasone cream and ointment according to indications.

Interaction with other drugs

Due to the chemical properties of mometasone furoate, it is incompatible with alkalis. Other interactions have not been described.

Overdose

An overdose of Mometasone is characterized by the development of systemic effects characteristic of all GCS. Treatment is symptomatic.

Release form

Cream 0.1% in tubes of 15 g.

Ointment 0.1% in tubes of 15 g.

Storage conditions

The temperature at the place where the drug is stored should not exceed 25 degrees Celsius.

Synonyms

Nasonex, Elocom, Twistheiler, Momat, Mometasone furoate, Nasonex, Uniderm.

Compound

1 g of ointment contains 1 mg of mometasone furoate.

Additional ingredients: propylene glycol monopalmitostearate, white wax, hexylene glycol, diluted phosphoric acid, purified water, white soft paraffin (white petroleum jelly).

Additional ingredients: glyceryl monostearate 40-55, hexylene glycol, macrogol 20 cetostearyl ether, cetostearyl alcohol, titanium dioxide (E171), white wax, aluminum salt of starch octenyl succinate, diluted phosphoric acid, purified water, white soft paraffin (white petroleum jelly).

Additionally

Mometasone ointment and cream are not used in ophthalmology; do not allow the drug to come into contact with the eyes.

Systemic absorption of Mometasone can lead to reversible inhibition of the hypothalamic-pituitary-adrenal axis. Glucosuria, hyperglycemia, and Cushing's syndrome may also develop. Withdrawal syndrome may develop after discontinuation of Mometasone therapy.

If the patient uses Mometasone on large areas of the skin or uses an occlusive dressing, constant monitoring of the functioning of the hypothalamic-pituitary-adrenal axis is necessary for timely diagnosis of the systemic effect of the drug. For this purpose, the morning cortisol content in the blood plasma is determined and an ACTH stimulation test is performed. If a systemic effect is established, it is necessary to discontinue the drug or increase the interval between applying the cream or ointment. Soon after GCS is discontinued, the functions of the hypothalamic-pituitary-adrenal system are fully restored.

If local infectious lesions occur during the use of Mometasone, appropriate antibacterial or antifungal treatment must be prescribed. Mometasone therapy should be suspended during treatment of infectious complications.

If treatment with Mometasone continues for more than 2 weeks, and there is no improvement in the condition, it is necessary to clarify the diagnosis.

In children over 2 years of age, Mometasone cream and ointment are used under medical supervision. Due to the larger ratio of skin surface area/body weight in relation to this value in adults, the risk of suppression of the hypothalamic-pituitary-adrenal system in children is much higher, and the risk of developing Cushing's disease and atrophic skin lesions also increases. Mometasone should not be used to treat diaper dermatitis.

Attention!

The description of the drug on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.

Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Source: http://www.matato.net/spravka/drugs/d3979-Mometasone

MOMETASONE INSTRUCTIONS

Prices for MOMETAZONE

Mometasone prevents the marginal accumulation of neutrophils, which reduces the production of lymphokines and inflammatory exudate, inhibits the movement of macrophages, leading to a decrease in the processes of granulation and infiltration. Inhibits the occurrence of immediate allergic reactions.

Mometasone has negligible bioavailability (≤0.1%). The degree of penetration of the active substance through the skin is determined by various factors (the integrity of the skin at the site of application, the composition of the drug). Studies conducted on volunteers have shown that about 0.4% of a dose of cream applied to intact skin is detected in the blood after 8 hours. Increased penetration of the drug through the skin can result from damage or inflammatory processes at the site of application.

Indications for the use of Mometasone ointment or cream are: itching and inflammation in dermatoses that are amenable to GCS therapy; conditions with symptoms of hyperkeratosis (chronic eczema, psoriasis, seborrheic and atopic dermatitis) in adults and children over two years of age.

A thin layer of Mometasone cream or ointment is applied to the affected area of ​​the skin once a day. The duration and regimen of treatment, as well as the required dosage form, are determined by the doctor in each specific case.

External applications of Mometasone can lead to the following local side effects: itching, burning, rosacea, skin atrophy. In rare cases, local use of GCS can lead to the following side effects: folliculitis, irritation and dry skin, acne, hypertrichosis, perioral dermatitis, hypopigmentation, secondary infection, miliaria, stretch marks, contact allergic dermatitis. When using occlusive dressings, the likelihood of these side effects increases.

If during therapy with Mometasone changes appear on the skin at the site of application of the drug, treatment is stopped.

Contraindications to the use of Mometasone are: age under 2 years; hypersensitivity to mometasone furoate, auxiliary components of the drug or other corticosteroids; lactation.

Mometasone is also contraindicated in persons who have recently undergone trauma or surgery on the nose until post-surgical wounds have completely healed.

It is possible to use Mometasone cream and ointment according to indications.

Due to the chemical properties of mometasone furoate, it is incompatible with alkalis. Other interactions have not been described.

An overdose of Mometasone is characterized by the development of systemic effects characteristic of all GCS. Treatment is symptomatic.

The temperature at the place where the drug is stored should not exceed 25 degrees Celsius.

Mometasone - cream 0.1% in tubes of 15 g.

Mometasone - ointment 0.1% in tubes of 15 g.

1 g of Mometasone ointment contains 1 mg of mometasone furoate.

Additional ingredients: propylene glycol monopalmitostearate, white wax, hexylene glycol, diluted phosphoric acid, purified water, white soft paraffin (white petroleum jelly).

Additional ingredients: glyceryl monostearate 40-55, hexylene glycol, macrogol 20 cetostearyl ether, cetostearyl alcohol, titanium dioxide (E171), white wax, aluminum salt of starch octenyl succinate, diluted phosphoric acid, purified water, white soft paraffin (white petroleum jelly).

Mometasone ointment and cream are not used in ophthalmology; do not allow the drug to come into contact with the eyes.

Systemic absorption of Mometasone can lead to reversible inhibition of the hypothalamic-pituitary-adrenal axis. Glucosuria, hyperglycemia, and Cushing's syndrome may also develop. Withdrawal syndrome may develop after discontinuation of Mometasone therapy.

If the patient uses Mometasone on large areas of the skin or uses an occlusive dressing, constant monitoring of the functioning of the hypothalamic-pituitary-adrenal axis is necessary for timely diagnosis of the systemic effect of the drug. For this purpose, the morning cortisol content in the blood plasma is determined and an ACTH stimulation test is performed. If a systemic effect is established, it is necessary to discontinue the drug or increase the interval between applying the cream or ointment. Soon after GCS is discontinued, the functions of the hypothalamic-pituitary-adrenal system are fully restored.

The drug should not be applied to the face, in the area of ​​the groin folds and the axillary area.

If local infectious lesions occur during the use of Mometasone, appropriate antibacterial or antifungal treatment must be prescribed. Mometasone therapy should be suspended during treatment of infectious complications.

If treatment with Mometasone continues for more than 2 weeks, and there is no improvement in the condition, it is necessary to clarify the diagnosis.

In children over 2 years of age, Mometasone cream and ointment are used under medical supervision. Due to the larger ratio of skin surface area/body weight in relation to this value in adults, the risk of suppression of the hypothalamic-pituitary-adrenal system in children is much higher, and the risk of developing Cushing's disease and atrophic skin lesions also increases. Mometasone should not be used to treat diaper dermatitis.

Ointment and cream are not recommended for use under occlusive dressings or waterproof underwear due to the increased risk of developing systemic complications.

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Source: http://www.medcentre.com.ua/medicamenty/mometazon.html

Mometasone is a topical glucocorticosteroid drug

Medicines that are glucocorticosteroids, when applied topically, successfully solve problems associated with skin diseases (various dermatitis). However, caution must be exercised when using them due to the possibility of side effects.

Features of the drug

A drug that contains glucocorticosteroid ingredients may affect the functioning of the hypothalamic-pituitary-adrenal system. This happens because the glucocorticoid is a synthetic analogue of the substance that this system produces in the body.

After stopping the use of the drug, adrenal function is restored. Due to the very poor absorption of the drug’s ingredients by the body, there is little risk of them entering the patient’s circulatory system. You should follow the instructions for use, namely, do not use the product if the surface of the mucous layer or skin is damaged.

Dosage forms

Manufacturers produce the drug for external use in the form of:

The drug is also used for inhalation of the nasal passages, and for this purpose there is a dosage form in the form of a nasal spray.

Composition of Mometasone

The main active ingredient is mometasone. The cream contains additional substances:

  • macrogol,
  • glyceryl monostearate,
  • white wax,
  • phosphoric acid,
  • hexylene glycol,
  • cetostearyl ether,
  • cetostearyl alcohol,
  • white paraffin,
  • purified water,
  • titanium dioxide

The ointment, in the form of additional ingredients, includes:

  • hexylene glycol,
  • propylene glycol monopalmitostearate,
  • white paraffin,
  • white wax,
  • phosphoric acid,
  • purified water.

Average cost of a drug in a pharmacy chain:

pharmachologic effect

The drug is endowed with the ability to cause the following effects in the body:

  • vasoconstrictor effect,
  • antiallergic protection,
  • anti-inflammatory effect,
  • antipruritic effect.

Pharmacodynamics

The mechanism of action of mometasone is based on the fact that reactions that are initiated in cells by the active substance reduce the possibility of an inflammatory process. In addition, allergic reactions are inhibited at any stage of development.

Pharmacokinetics

Studies have shown that the components of the drug do not accumulate in the body. The presence of the drug substance in the skin, eight hours after application of the product, was 0.4% of the dose. The product was applied to the skin in the form of an application; no bandage was applied.

When the drug enters the body through the nasal route, it was found that its bioavailability is 0.1% of the dose used and even less. The presence of the substance was determined eight hours after application of the drug (in the circulatory system).

Indications

The specialist prescribes mometasone for treatment if the patient has the following problems:

Instructions for use

  • The drug, in the form of an ointment or cream, is used externally to treat dermatitis. Apply a thin layer of the product to the affected surface. The procedure is carried out once a day.
  • The lotion is used to improve the health of the scalp. The product is used in this way: apply the liquid to the skin, while simultaneously gently rubbing until the liquid is completely absorbed.
  • Nasal spray is used for inhalation into the nasal passages. For this, a special nozzle is used. One release of the substance after pressing the button on the bottle is approximately 100 mcg. But before you start using the bottle, you must make seven presses in a row so that the next press will dispense the suspension.

For adults

  • Using a cream, ointment or lotion to treat affected areas of the skin has the same recommendations for children and adults. The nasal spray is prescribed to different age categories using the appropriate dose.
  • For adult patients and children over 12 years of age, the use of nasal spray is recommended at a daily dose of 200 mcg. Inhalation is carried out twice a day using 50 mcg of suspension in each nostril for the procedure.
  • If there is no desired effect, then the daily dose of the substance used is increased to 400 mcg. At the same time, the number of procedures is increased from two to four. If signs of improvement appear, the dose is recommended to be reduced.

For children

In childhood, the nasal spray is recommended to be used once a day, 50 mcg in each nostril. The daily dose for inhalation into the nasal passages is 100 mcg. The age at which experts allow the use of the product for nasal inhalation is 2 years.

Children are more susceptible to possible side effects of the drug, so its use must be carried out under the close supervision of a specialist.

During pregnancy and lactation

The condition of bearing a child and breastfeeding is a reason for contraindications to the use of the drug. There is insufficient research into how dangerous or safe it is to be treated with mometasone for the previously mentioned conditions.

In each individual case, the decision to prescribe the drug remains with the doctor. The principle on which the choice is made is that the benefits of use exceed the possible harm from the drug.

Contraindications

Mometasone is not prescribed if the patient has the following problems or circumstances:

  • there is a violation of the integrity of the skin or mucous membrane (due to disease, injury, recent surgery);
  • childhood period (up to two years),
  • increased individual sensitivity to the ingredients of the drug,
  • The patient has an infection that has not been treated:
    • tuberculosis infection,
    • fungal infection of the skin,
    • herpes,
    • viral or bacterial infection.

Side effects

When using the drug to treat skin diseases, undesirable effects may occur:

special instructions

  • The use of occlusive dressings increases the side effects of the drug. Since hormonal drugs can create reversible inhibition of the vital functions of the hypothalamic-pituitary-adrenal system, it is necessary to use the drug without exceeding the recommended dose, and at the first sign of side effects, discontinue it or reduce the dose.
  • The drug should not be applied to the face area; you should especially protect your eyes from getting the product on the mucous surface. Mometasone is also not used in the area of ​​the inguinal and axillary folds.
  • If a concomitant infection occurs, it is necessary to carry out symptomatic treatment of this phenomenon, and it is recommended to temporarily suspend the use of momesatone.

Interaction with other drugs

The chemical properties of the ingredients allow us to conclude that the drug is not compatible with alkalis. Other undesirable drug interactions have not yet been described in the medical literature.

Reviews

Users note that the drug is very effective. Side effects are not common.

Treatment of allergic dermatitis with the drug, using daily application, showed a therapeutic result after three weeks.

Source: http://gidmed.com/dermatologiya/lekarstva-derm/mometazon.html

Mometasone

Instructions for use:

Mometasone is a synthetic glucocorticosteroid (GCS) drug for topical use with anti-inflammatory, antiallergic, antiexudative and antipruritic effects.

Release form and composition

The active ingredient of Mometasone is mometasone furoate, 1 mg of ointment or cream contains 1 mg.

  • Ointment: propylene glycol monopalmitostearate, hexylene glycol, white wax, diluted phosphoric acid, white soft paraffin (white petroleum jelly), purified water;
  • Cream: glyceryl monostearate 40-55, macrogol 20 cetostearyl ether, hexylene glycol, cetostearyl alcohol, titanium dioxide (E171), aluminum salt of starch octenyl succinate, white soft paraffin (white petroleum jelly), diluted phosphoric acid, white wax, purified water.

Pharmacological properties

Pharmacodynamics

Mometasone furoate is a synthetic glucocorticosteroid. It has anti-inflammatory, antiexudative and antipruritic effects.

Glucocorticosteroids induce the release of lipocortins - special proteins that inhibit phospholipase A 2 . Lipocortins control the biosynthesis of leukotrienes and prostaglandins (inflammatory mediators) by inhibiting the release of arachidonic acid, which is a common precursor of these inflammatory mediators.

Pharmacokinetics

Mometasone is practically not absorbed. 8 hours after applying the drug to intact skin (without using an occlusive dressing), no more than 0.7% of mometasone is detected in the patient’s blood.

Indications for use

  • Dermatoses with itching and inflammation, amenable to treatment with GCS;
  • Chronic eczema, atopic and seborrheic dermatitis, psoriasis and other pathologies with symptoms of hyperkeratosis.

Contraindications

  • Age up to 2 years;
  • Conditions after a recent injury or surgery on the nose (until complete healing);
  • Breastfeeding period;
  • Diaper dermatitis;
  • Hypersensitivity to GCS and drug components.

Instructions for use of Mometasone: method and dosage

Mometasone cream and ointment are intended for topical use.

The product should be applied in a thin layer to the affected areas of the skin once a day.

The regimen and duration of treatment are prescribed by a doctor based on clinical indications.

Side effects

  • Rarely: dryness and irritation of the skin, folliculitis, acne, perioral dermatitis, hypertrichosis, secondary infection, hypopigmentation, miliaria, allergic contact dermatitis, stretch marks;
  • Other: against the background of the use of occlusive dressings - burning, itching, rosacea, skin atrophy.

If signs of adverse reactions appear at the site of application of the drug, the use of Mometasone should be discontinued.

Overdose

In case of an overdose of the drug, symptoms of suppression of the function of the hypothalamic-pituitary-adrenal system, including secondary adrenal insufficiency, are observed.

In case of overdose, symptomatic treatment is prescribed. If necessary, correct the water-electrolyte balance and discontinue the drug. With long-term treatment, Mometasone should be discontinued gradually.

special instructions

Avoid getting Mometasone cream or ointment in your eyes.

Do not apply the drug to the face, in the axillary area and in the area of ​​the groin folds.

Systemic absorption can cause reversible inhibition of the hypothalamic-pituitary-adrenal system, the development of glucosuria, hyperglycemia, Cushing's syndrome; with long-term use over large areas - withdrawal syndrome.

Due to the risk of systemic complications, Mometasone is not recommended for use under waterproof underwear or occlusive dressings.

In case of a large affected area or the need to use occlusive dressings, treatment should be accompanied by monitoring the function of the hypothalamic-pituitary-adrenal system. This will allow you to diagnose the initial signs of the systemic effect of the drug and promptly increase the interval between application of the drug or discontinue its use.

If infectious complications of bacterial or fungal origin develop during therapy, the patient should temporarily stop using Mometasone and consult a doctor for appropriate therapy.

Treatment of children must be carried out under regular medical supervision, since the risk of developing atrophic skin lesions, Cushing's syndrome and a functional disorder of the hypothalamic-pituitary-adrenal system is much higher in them than in adults.

If there is no clinical effect after 2 weeks of using Mometasone, you should consult a doctor to clarify the diagnosis.

Use during pregnancy and lactation

There is insufficient data on the safety of the drug in pregnant and lactating women.

Since glucocorticosteroids can penetrate the placental barrier and have a negative effect on the embryonic development of the fetus, the use of Mometasone during pregnancy is possible only in small doses and for a short time.

During long-term therapy with glucocorticosteroids and/or use of the drug in large doses, breastfeeding should be discontinued, since glucocorticosteroids are excreted in breast milk.

Use in childhood

According to the instructions, Mometasone is contraindicated in children under 2 years of age, since there is insufficient data on its safety and effectiveness at this age.

Drug interactions

The drug is incompatible with alkali-containing products.

Analogs

Analogues of Mometasone are: Momat, Nasonex, Elokom, Uniderm, Twistheiler.

Terms and conditions of storage

Store out of reach of children at temperatures up to 25°C.

Conditions for dispensing from pharmacies

Dispensed by prescription.

Reviews about Mometasone

The drug is effective for various dermatoses, which is confirmed by reviews of Mometasone. The result of the treatment is noticeable after 10 days of using the cream or ointment. It should be noted that some patients report becoming accustomed to the drug, which may result in a need to increase the dose. There is also mention of skin burns when the treated areas are irradiated with ultraviolet rays.

Price for Mometasone in pharmacies

To date, the price of Mometasone is unknown, since the drug is very rarely found in pharmacies. Average prices for similar medicines with the same active substance are as follows:

  • Momat, cream 0.1%, 5 g – 160 rubles;
  • Nasonex, spray 50 mcg/dose, 60 doses – 450 rubles;
  • Uniderm, cream 0.1%, 15 g – 180 rubles;
  • Elokom, cream 0.1%, 15 g – 330 rubles.

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Source: http://www.neboleem.net/mometazon.php