Lincomycin dosage for adults

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Lincomycin - instructions for use, reviews, analogs and release forms (capsules or tablets 250 mg hydrochloride, injections in injection ampoules, ointment) of a drug for the treatment of abscess, endocarditis in adults, children and pregnancy

In this article you can read the instructions for use of the drug Lincomycin.

Table of contents:

Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Lincomycin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Lincomycin in the presence of existing structural analogues. Use for the treatment of abscess, endocarditis and other infectious and inflammatory diseases in adults, children, as well as during pregnancy and lactation.

Lincomycin is an antibiotic of the lincosamide group. In therapeutic doses it acts bacteriostatically. At higher concentrations it has a bactericidal effect. Suppresses protein synthesis in microbial cells.

Active primarily against aerobic gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae /except Enterococcus faecalis/), Corynebacterium diphtheriae; anaerobic bacteria Clostridium spp., Bacteroides spp.

Lincomycin is also active against Mycoplasma spp.

Most gram-negative bacteria, fungi, viruses, and protozoa are resistant to lincomycin. Resilience is developed slowly.

Cross-resistance exists between lincomycin and clindamycin.

Lincomycin (in the form of hydrochloride monohydrate) + excipients.

After oral administration, 30-40% is absorbed from the gastrointestinal tract. Eating slows down the rate and extent of absorption. Lincomycin is widely distributed in tissues (including bone) and body fluids. Penetrates through the placental barrier. Partially metabolized in the liver. It is excreted unchanged and in the form of metabolites in urine, bile and feces.

  • severe infectious and inflammatory diseases caused by microorganisms sensitive to lincomycin, incl. sepsis, osteomyelitis, septic endocarditis, pneumonia, lung abscess, pleural empyema, wound infection;
  • as a reserve antibiotic for infections caused by strains of staphylococcus and other gram-positive microorganisms resistant to penicillin and other antibiotics;
  • for local use: purulent-inflammatory skin diseases.

250 mg capsules (sometimes mistakenly called tablets).

Solution for intravenous and intramuscular administration (injections in injection ampoules) 300 mg/ml.

Ointment for external use.

Instructions for use and dosage

When taken orally by adults - 500 mg 3-4 times a day or intramuscularly - 600 mg 1-2 times a day. 600 mg is administered intravenously in 250 ml of isotonic sodium chloride or glucose solution 2-3 times a day.

Children aged 1 month to 14 years intramg/kg per day; administered intravenously drip to dosemg/kg every 8-12 hours.

When applied topically, apply a thin layer to the affected areas of the skin.

  • nausea, vomiting;
  • epigastric pain;
  • diarrhea;
  • glossitis;
  • stomatitis;
  • with long-term use in high doses, the development of pseudomembranous colitis is possible;
  • reversible leukopenia, neutropenia, thrombocytopenia;
  • hives;
  • exfoliative dermatitis;
  • Quincke's edema;
  • anaphylactic shock;
  • candidiasis;
  • phlebitis (with intravenous administration);
  • decreased blood pressure, dizziness, general weakness (with rapid intravenous administration).
  • severe dysfunction of the liver and/or kidneys;
  • pregnancy;
  • lactation;
  • hypersensitivity to lincomycin and clindamycin.

Use during pregnancy and breastfeeding

Lincomycin crosses the placental barrier and is excreted in breast milk. Use during pregnancy is contraindicated. If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.

If liver and/or kidney function is impaired, the single dose of lincomycin should be reduced by 1/3 - 1/2 and the interval between doses should be increased. With long-term use, systematic monitoring of kidney and liver functions is necessary.

If pseudomembranous colitis develops, lincomycin should be discontinued and vancomycin or bacitracin should be prescribed.

When used simultaneously with penicillins, cephalosporins, chloramphenicol or erythromycin, antagonism of the antimicrobial effect is possible.

When used simultaneously with aminoglycosides, synergistic action is possible.

When used simultaneously with inhalation anesthesia or peripherally acting muscle relaxants, an increase in neuromuscular blockade is observed, up to the development of apnea.

Taking antidiarrheal drugs reduces the effect of lincomycin.

Pharmaceutically incompatible with ampicillin, barbiturates, theophylline, calcium gluconate, heparin and magnesium sulfate.

Lincomycin is incompatible in the same syringe or dropper with kanamycin or novobiocin.

Analogues of the drug Lincomycin

Structural analogues of the active substance:

  • Lincomycin-AKOS;
  • Lincomycin hydrochloride;
  • Lincomycin hydrochloride capsules 0.25 g;
  • Lincomycin hydrochloride solution for injection 30%;
  • Neloren;
  • Films with lincomycin.

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Lincomycin

Prices in online pharmacies:

Lincomycin is an antibiotic from the lincosamide group.

Composition and release form of Lincomycin

Lincomycin is available in various dosage forms:

  • Lincomycin capsules;
  • Lyophilisate for preparing a solution for intramuscular and intravenous administration;
  • Solution for intramuscular and intravenous administration;
  • Lincomycin ointment for external use.

The main active ingredient of the drug is lincomycin hydrochloride.

Pharmacological action of Lincomycin

According to the instructions, Lincomycin is an antibiotic produced by Streptomyces lincolniensis, which has a pronounced bacteriostatic effect. The use of Lincomycin inhibits the synthesis of bacterial proteins and disrupts the formation of peptide bonds.

Lincomycin hydrochloride is active against some gram-positive cocci, Mycoplasma spp., Bacillus anthracis, Haemophilus influenzae, Corynebacterium diphtheriae, Bacteroides spp., Clostridium tetani, Clostridium perfringens. Effective against Staphylococcus spp., resistant to tetracyclines, penicillin, streptomycin, chloramphenicol and cephalosporins.

It works most effectively in an alkaline environment (pH 8-8.5).

Indications for use of Lincomycin

According to the instructions, Lincomycin is prescribed for the treatment of bacterial infections caused by microorganisms sensitive to lincomycin hydrochloride (streptococci and staphylococci), as well as microorganisms resistant to penicillins, or in case of allergies to the penicillin group:

  • Subacute septic endocarditis;
  • Sepsis;
  • Chronic pneumonia;
  • Osteomyelitis (in chronic or acute form);
  • Otitis;
  • Pleurisy;
  • Empyema of the pleura;
  • Lung abscess;
  • Purulent arthritis;
  • Purulent complications in the postoperative period;
  • Infections of soft tissues and skin;
  • Wound infections.

In dentistry, Lincomycin is prescribed for the treatment of various infections of the maxillofacial system. As a rule, dentists prefer this drug for its ability to be deposited in teeth and bone tissue.

The use of Lincomycin in dentistry in combination with lidocaine for the treatment of purulent processes in periodontitis, gingivitis, and periodontitis is widespread. Since there are no direct indications for the use of Lincomycin in dentistry, the issue of prescribing the drug must be resolved only with the attending physician.

Directions for use and dosage

The daily dose of Lincomycin for parenteral administration is 1.8 g, single - no more than 0.6 g. If the infection is severe, the dosage can be increased to 2.4 g, divided into three doses with an eight-hour interval. For children, the dose of lyophilisate when administered intravenously is mg/kg, regardless of age. Lincomycin is administered intravenously only by drip, the optimal rate is drip/min.

Lincomycin capsules are taken orally 1-2 hours before meals. For adults, the maximum dosage of Lincomycin capsules is 1-1.5 g, and a single dosage is no more than 0.5 g. For children, Lincomycin capsules cannot be prescribed more than mg/kg per day.

The duration of treatment with Lincomycin depends on the form of the disease, but generally does not exceed 1-2 weeks. The exception is osteomyelitis, when treatment can last up to three or more weeks.

If the course of treatment is long, it is necessary to monitor liver and kidney functions.

Contraindications

Lincomycin in any dosage form is contraindicated:

  • In case of hypersensitivity to lincomycin hydrochloride;
  • During pregnancy and breastfeeding (it has been proven that lincomycin hydrochloride passes through the placenta and into breast milk);
  • In case of severe renal and liver failure;
  • In childhood up to 1 month.

According to the instructions, Lincomycin is prescribed with caution for fungal diseases of the skin, vagina, oral mucosa, myasthenia gravis (when administered parenterally).

Side effects of Lincomycin

The use of Lincomycin may cause the following adverse reactions:

  • Hematopoietic system: reversible thrombocytopenia, leukopenia, neutropenia;
  • Digestive system: diarrhea, nausea, vomiting, pain in the epigastric region, glossitis, gastrointestinal candidiasis, increased activity of liver enzymes, transient hyperbilirubinemia, pseudomembranous enterocolitis;
  • Allergies: exfoliative dermatitis, urticaria, anaphylactic shock, angioedema.

With intravenous administration, phlebitis may develop. If administered intravenously too quickly, a decrease in blood pressure, asthenia, dizziness, and weakness of skeletal muscles may occur.

special instructions

To prevent the development of aseptic necrosis and thrombophlebitis, it is better to administer Lincomycin deeply intramuscularly. It is prohibited to administer the drug intravenously without prior dilution.

Caution should be exercised when prescribing the parenteral form of the drug to premature infants, as this can lead to the development of bronchospasm.

Drug interactions

Lincomycin hydrochloride is pharmaceutically incompatible with ampicillin, theophylline, kanamycin, calcium gluconate, magnesium sulfate, barbiturates, and heparin.

It is not recommended to use Lincomycin in combination with erythromycin. Antidiarrhea medications reduce the effect of Lincomycin.

When administered parenterally, Lincomycin enhances the neuromuscular blockade caused by muscle relaxants.

Lincomycin caps. 250 mg No. 20

Lincomycin caps. 250 mg No. 20

Lincomycin capsules 250 mg 20 pcs.

Lincomycin ointment 2% 15g

Lincomycin 250 mg No. 20 caps

Lincomycin capsules 250 mg n20

Lincomycin 250 mg No. 20 capsules

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A smear for oncocytology (Papanicolaou analysis, Pap test) is a method of microscopic examination of cells that are taken from the surface of the skin.

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LINCOMYCIN

Antibiotic of the lincosamide group. In therapeutic doses it acts bacteriostatically. At higher concentrations it has a bactericidal effect. Suppresses protein synthesis in microbial cells.

Active primarily against aerobic gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae /except Enterococcus faecalis/), Corynebacterium diphtheriae; anaerobic bacteria Clostridium spp., Bacteroides spp.

Lincomycin is also active against Mycoplasma spp.

Most gram-negative bacteria, fungi, viruses, and protozoa are resistant to lincomycin. Resilience is developed slowly.

Cross-resistance exists between lincomycin and clindamycin.

Severe infectious and inflammatory diseases caused by microorganisms sensitive to lincomycin, incl. sepsis, osteomyelitis, septic endocarditis, pneumonia, lung abscess, pleural empyema, wound infection. As a reserve antibiotic for infections caused by strains of staphylococcus and other gram-positive microorganisms resistant to penicillin and other antibiotics.

For external use: purulent-inflammatory skin diseases.

When taken orally by adults - 500 mg 3-4 times / day or intramuscularly - 600 mg 1-2 times / day. 600 mg is administered intravenously in 250 ml of isotonic sodium chloride or glucose solution 2-3 times a day.

Children aged 1 month to 14 years intramg/kg/day; Injected intravenously into dosemg/kg every 8-12 hours.

For external use, apply a thin layer to the affected areas of the skin.

From the digestive system: nausea, vomiting, epigastric pain, diarrhea, glossitis, stomatitis; transient increase in the level of liver transaminases and bilirubin in the blood plasma; with long-term use in high doses, the development of pseudomembranous colitis is possible.

From the hematopoietic system: reversible leukopenia, neutropenia, thrombocytopenia.

Allergic reactions: urticaria, exfoliative dermatitis, Quincke's edema, anaphylactic shock.

Effects due to chemotherapy: candidiasis.

Local reactions: phlebitis (with intravenous administration).

With rapid intravenous administration: decreased blood pressure, dizziness, general weakness, relaxation of skeletal muscles.

When used simultaneously with penicillins, cephalosporins, chloramphenicol or erythromycin, antagonism of the antimicrobial effect is possible.

When used simultaneously with aminoglycosides, synergistic action is possible.

When used simultaneously with inhalation anesthesia or peripherally acting muscle relaxants, an increase in neuromuscular blockade is observed, up to the development of apnea.

Taking antidiarrheal drugs reduces the effect of lincomycin.

Pharmaceutically incompatible with ampicillin, barbiturates, theophylline, calcium gluconate, heparin and magnesium sulfate.

Lincomycin is incompatible in the same syringe or dropper with kanamycin or novobiocin.

If liver and/or kidney function is impaired, the single dose of lincomycin should be reduced by 1/3-1/2 and the interval between doses should be increased. With long-term use, systematic monitoring of kidney and liver functions is necessary.

If pseudomembranous colitis develops, lincomycin should be discontinued and vancomycin or bacitracin should be prescribed.

Contraindicated in cases of severe renal impairment.

If renal function is impaired, the single dose of lincomycin should be reduced by 1/3 - 1/2 and the interval between doses should be increased. With long-term use, systematic monitoring of renal function is necessary.

Contraindicated in cases of severe liver dysfunction.

If liver function is impaired, the single dose of lincomycin should be reduced by 1/3 - 1/2 and the interval between doses should be increased. With long-term use, systematic monitoring of liver function is necessary.

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Lincomycin

Instructions for use:

Prices in online pharmacies:

Lincomycin is a drug with an antibacterial effect.

Release form and composition

Lincomycin is available in the following forms:

  • Capsules (10 or 20 pcs. in dark glass or polymer jars, 1 jar in a cardboard pack; 10 pcs. in blister packs, 1, 2, 150 packs in a cardboard pack);
  • Solution for intravenous and intramuscular administration (1 or 2 ml in ampoules complete with an ampoule knife, 10 ampoules in a cardboard box, or 5 or 10 ampoules in blister packs, 1 or 2 packages in a cardboard box).
1 capsule contains:
  • Active substance: lincomycin hydrochloride monohydrate – 250 mg (in terms of lincomycin);
  • Auxiliary components: potato starch, sucrose (powdered sugar).

Capsule shell composition: sodium lauryl sulfate, water, gelatin, propylparaben (propyl parahydroxybenzoate), methylparaben (methyl parahydroxybenzoate), dyes: sunset yellow dye (E 110), quinoline yellow (E 104), titanium dioxide.

The composition of 1 ml of solution for injection includes the active substance: lincomycin hydrochloride – 300 mg.

Indications for use

Lincomycin is prescribed for the treatment of the following infectious and inflammatory diseases caused by microorganisms sensitive to the action of the active substance (primarily streptococci and staphylococci, especially microorganisms that are resistant to penicillins, as well as in the presence of an allergy to penicillins):

  • Otitis;
  • Subacute septic endocarditis;
  • Sepsis;
  • Postoperative purulent complications;
  • Chronic pneumonia;
  • Wound infections;
  • Empyema of the pleura;
  • Lung abscess;
  • Pleurisy;
  • Purulent arthritis;
  • Osteomyelitis (chronic and acute).

The drug is also indicated for infections of soft tissues and skin, including furunculosis, pyoderma, erysipelas and phlegmon.

Contraindications

  • Hepatic-renal failure;
  • Pregnancy;
  • Hypersensitivity to the components of the drug.

Additionally, contraindications to the use of Lincomycin in capsule form are:

Capsules should be taken with caution by patients with fungal diseases of the oral mucosa, skin and vagina.

Directions for use and dosage

Lincomycin in capsule form should be taken orally, observing intervals with meals (1-2 hours before or 2-3 hours after meals).

The frequency of taking the drug is 2-3 times a day with equal breaks (8-12 hours).

For adults, Lincomycin is prescribed in a single dose of 500 mg mg per day). The daily dose for children 3-14 years old is mg/kg.

The duration of therapy is determined by the form and severity of the disease. On average, it lasts 1-2 weeks; in the treatment of osteomyelitis, longer treatment is possible (from 3 weeks).

When conducting repeated courses of therapy or during long-term treatment, it is necessary to monitor the functional state of the kidneys and liver.

Lincomycin solution should be administered intramuscularly to adults 2 times a day, 500 mg. In severe cases, it is possible to use the drug 3 times a day.

For children, Lincomycin is prescribed in a daily dose of mg/kg in 2 administrations.

It is also possible to administer the drug intravenously (60-80 drops per minute) at a dose of 600 mg 3 times a day.

The duration of the course is 1-2 weeks, in some cases treatment is carried out for a month.

Side effects

During therapy, the following side effects may develop:

  • Hematopoietic organs: thrombocytopenia, reversible leukopenia and neutropenia;
  • Digestive system: epigastric pain, nausea, diarrhea, vomiting, increased activity of liver transaminases, abdominal pain, stomatitis, glossitis, transient hyperbilirubinemia; with prolonged use - pseudomembranous enterocolitis, candidiasis of the gastrointestinal tract. It is also possible to develop other fungal infections of the genital tract;
  • Allergic reactions: exfoliative dermatitis, urticaria, anaphylactic shock, angioedema.

special instructions

To achieve optimal absorption from the gastrointestinal tract, it is not recommended to eat for 1-2 hours before and after taking Lincomycin.

For patients with functional disorders of the kidneys and/or liver, the single dose of the drug should be reduced by 1/3-1/2, and the interval between doses should be increased. For patients with liver failure, therapy is possible only for health reasons.

With prolonged use of Lincomycin, liver and kidney function should be systematically monitored.

The use of Lincomycin for the treatment of meningitis is not recommended.

With the development of symptoms of pseudomembranous enterocolitis (discharge of blood and mucus with feces, leukocytosis, diarrhea, abdominal pain, fever), in mild cases, it is sufficient to discontinue Lincomycin and prescribe ion exchange resins (cholestyramine). In severe cases of the disease, replacement of the loss of fluid, protein and electrolytes, oral administration of vancomycin (in 3-4 doses for 10 days) or bacitracin is indicated.

Drug interactions

  • Antagonism: with chloramphenicol, erythromycin, ampicillin and other bactericidal antibiotic drugs;
  • Synergism: with aminoglycosides.

The drug is chemically incompatible with kanamycin and novobiocin, so they should not be administered in the same syringe or dropper.

Cross-resistance exists between clindamycin and lincomycin.

The effect of therapy is reduced by antidiarrheal drugs (the interval between their use should be at least 4 hours).

Lincomycin enhances the effect of drugs used for inhalation anesthesia, opioid analgesics and muscle relaxants, increasing the risk of respiratory arrest and the development of neuromuscular blockade.

Terms and conditions of storage

Store in a dry, dark place, out of reach of children.

Shelf life – 3 years at temperatures:

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Lincomycin caps. 250 mg No. 20

Lincomycin caps. 250 mg No. 20

Lincomycin capsules 250 mg 20 pcs.

Lincomycin ointment 2% 15g

Lincomycin 250 mg No. 20 caps

Lincomycin capsules 250 mg n20

Lincomycin 250 mg No. 20 capsules

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Lincomycin

Prices in online pharmacies:

Lincomycin is an antibiotic of the lincosamide group, which in therapeutic doses has a bacteriostatic effect, and in higher concentrations it has a bactericidal effect. Shows activity against a wide range of aerobic gram-positive bacteria, some anaerobic bacteria, as well as Mycoplasma spp.

Release form and composition

Dosage forms of Lincomycin:

  • Solution for intravenous (IV) and intramuscular (IM) administration (in ampoules of 1 ml, in a cardboard box of 10 ampoules);
  • Capsules (10 pcs. in a strip packaging, 2 packs in a cardboard box; 20 pcs. in a dark glass jar, 1 jar in a cardboard box).

Active substance: lincomycin (in the form of hydrochloride) – 250 mg in one capsule; 300 mg in 1 ml solution.

Indications for use

  • Severe infectious and inflammatory diseases caused by microorganisms sensitive to the drug, namely: osteomyelitis, sepsis, pneumonia, septic endocarditis, pleural empyema, lung abscess, wound infection;
  • Infections initiated by strains of staphylococcus and other gram-positive microorganisms that exhibit resistance to penicillin and other antibiotics (as a reserve antibacterial agent).

Contraindications

  • Severe liver and/or kidney dysfunction;
  • Breastfeeding period (excreted in breast milk);
  • Pregnancy;
  • Hypersensitivity to lincomycin and clindamycin.

Directions for use and dosage

Capsules are taken orally; adults are prescribed 500 mg 3-4 times a day.

The solution is administered intramuscularly at 600 mg 1-2 times a day, intravenously - 2-3 times a day at 600 mg, diluted in 250 ml of an isotonic solution of glucose or sodium chloride (administration rate drops per minute).

Children aged 1 month to 14 years are recommended to take orally in doses of up to 1 mg/kg of body weight per day, intravenously every 8-12 hours per mg/kg of body weight.

The course of therapy is 7-14 days, maximum – up to 1 month.

Side effects

  • Hematopoietic system: neutropenia, reversible leukopenia, thrombocytopenia;
  • Digestive system: diarrhea, epigastric pain, vomiting, nausea, stomatitis, glossitis, transient increase in the level of bilirubin and liver transaminases in plasma, with a long course in high doses - pseudomembranous colitis;
  • Allergic reactions: exfoliative dermatitis, urticaria, anaphylactic shock, Quincke's edema;
  • Conditions caused by chemotherapeutic effects: candidiasis;
  • Local reactions: phlebitis (with intravenous administration).

In the case of rapid intravenous administration, the following may be observed: general weakness, dizziness, decreased blood pressure, relaxation of skeletal muscles.

special instructions

For moderate impairment of the kidneys and/or liver, it is recommended to reduce the single dose by one third or half, and also increase the interval between doses. During long-term therapy, systematic monitoring of renal and liver functions is required.

If pseudomembranous colitis develops, it is necessary to stop taking lincomycin and use bacitracin or vancomycin.

Drug interactions

Combination with saminoglycosides can lead to synergistic action, and with cephalosporins, penicillins, erythromycin and chloramphenicol - to antagonism of the antimicrobial action.

It should be taken into account that when used simultaneously with Lincomycin:

  • Antidiarrheal drugs – reduce its effectiveness;
  • Inhalation anesthesia agents, peripherally acting muscle relaxants - aggravate neuromuscular blockade, up to the development of apnea.

It must be remembered that the combination of lincomycin with barbiturates, ampicillin, theophylline, heparin, calcium gluconate and magnesium sulfate is pharmaceutically incompatible. The drug in the same syringe or dropper is also incompatible with novobiocin or kanamycin.

Terms and conditions of storage

Store at a temperature of 5-25 °C, in a place protected from light and out of reach of children.

Shelf life – 3 years.

Found an error in the text? Select it and press Ctrl + Enter.

Lincomycin caps. 250 mg No. 20

Lincomycin caps. 250 mg No. 20

Lincomycin capsules 250 mg 20 pcs.

Lincomycin ointment 2% 15g

Lincomycin 250 mg No. 20 caps

Lincomycin capsules 250 mg n20

Lincomycin 250 mg No. 20 capsules

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Complivit Selenium is a dietary supplement (BAA), an additional source of vitamins, and a mineral.

Complivit Oftalmo is a combined medicinal product containing vitamins, microelements and vitamins.

Complivit-Active is a multivitamin medicine with macro- and microelements. Release form and composition.

Complivit "Mama" for pregnant and lactating women.

Complivit “Mama” is a medicinal product that contains a complex of vit.

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Complivit Calcium D3 for babies is a calcium and vitamin D3 preparation developed.

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Lincomycin

Use of lincomycin

Lincomycin is an antibiotic that has a pronounced bactericidal effect against a wide range of pathogenic bacteria. Protozoa, viruses, fungi and gram-negative bacteria are resistant to the drug. Available in pharmacies according to prescription.

Diseases for which lincomycin is used

  • Sinusitis, otitis, lung abscess, pneumonia, pharyngitis. Other diseases of the respiratory system that are caused by infection.
  • Osteomyelitis, septic arthritis. Other diseases of the musculoskeletal system of an infectious nature.
  • Skin diseases of a purulent-inflammatory nature.
  • Infections introduced into the wound. Purulent wounds.
  • Furunculosis, erysipelas, other infectious diseases of the skin and soft tissues.

Instructions for use of lincomycin

Ingestion, intravenous, intramuscular, or local treatment. It is recommended to take the drug internally one minute before meals, or no earlier than 2 hours after meals. Capsules and tablets are swallowed whole and washed down with plenty of water.

Varieties of lincomycin

Tablets, capsules, ampoules, solution for external treatment.

Lincomycin dosage

The dosage is individual and adjusted for each patient. Disorders of the liver and kidneys necessarily require dosage adjustment.

Side effects of lincomycin

  • Pain in the lower abdomen.
  • Nausea and vomiting.
  • Increased amount of liver enzymes in the blood.
  • Diarrhea.
  • Stomatitis.
  • Pseudomembranous colitis (may develop with long-term use of the drug).
  • Decrease in the number of leukocytes and platelets in the blood.
  • Quincke's edema.
  • Phlebitis.
  • Anaphylactic shock.
  • Hives.
  • Dizziness.
  • Lethargy.
  • Slow reaction.

Contraindications for lincomycin

  • Hypersensitivity.
  • Pregnancy and breastfeeding.
  • Kidney failure.
  • Liver failure.

For kidney and liver diseases, the dosage of the drug must be reduced. A long course of treatment involves constant monitoring of the functionality of the liver and kidneys.

Lincomycin during pregnancy

It is not recommended to take the drug during pregnancy and breastfeeding. Do not take in the first trimester of pregnancy. In the second and third trimesters, lincomycin can be taken only if absolutely necessary. If the drug is taken during lactation, it is necessary to switch to artificial formula feeding. The antibiotic penetrates in high concentrations through the placenta into the fetus and into breast milk.

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Lincomycin - instructions for use

For use in dentistry, in the treatment of sinusitis, tracheitis, and other diseases of the ENT organs, Lincomycin is used - instructions for use of the medication describe the dosage regimen and indications. The drug for antibacterial therapy eliminates inflammatory processes, abscesses, and kills microorganisms that cause diseases. Read its instructions.

The drug Lincomycin

According to the pharmacological classification, Lincomycin is an antibacterial agent. This allows it to kill anaerobic bacteria that cause disease and impair the healing process. The antibiotic Lincomycin belongs to the lincosamide class and is available in several forms. The active ingredient in it is lincomycin hydrochloride.

Composition and release form

The drug can be purchased in the format of capsules (tablets), ointment (cream) and solution for injection. Detailed composition:

Capsules with white body and yellow cap, white powder inside

Transparent colorless liquid with a characteristic faint odor

White-yellowish ointment

Concentration of lincomycin hydrochloride

Excipients of the composition

Calcium stearate, colloidal silica, microcrystalline cellulose, gelatin, titanium dioxide

Disodium edetate, sodium hydroxide solution, water

Zinc oxide, paraffin, potato starch, petroleum jelly

6, 10 or 20 capsules

1 or 2 ml per ampoule, 5 or 10 ampoules per cardboard box with ampoule scarifier

10 or 15 g in aluminum tubes

Pharmacodynamics and pharmacokinetics

In therapeutic doses, the antibiotic acts bacteriostatically; in higher doses it has a bactericidal effect. Inhibits the protein synthesis of bacteria in the cell, is active against staphylococci, streptococci, clostridium bacteria, and mycoplasmas. The overwhelming majority of gram-negative bacteria, fungi, viruses and protozoan microorganisms are resistant to it.

When taken orally, it is absorbed from the stomach and intestinal tract by 35%; food intake slows down the rate and extent of absorption. The active substance is widely distributed in bone tissue and fluids and penetrates the placental barrier. Metabolism occurs in the liver, the half-life is five hours. It is excreted from the body by the kidneys and intestines with urine, bile and feces.

What is Lincomycin for?

Instructions for use indicate the following indications for use of the drug in patients:

  • severe diseases caused by microorganisms sensitive to the drug;
  • sepsis, osteomyelitis, septic endocarditis;
  • respiratory diseases: diphtheria, tonsillitis, bronchitis, tracheitis, laryngitis;
  • inflammation of the kneecap;
  • pneumonia, lung abscess, wound infections;
  • infections caused by strains of staphylococcus or other gram-positive bacteria resistant to penicillin;
  • pyoderma, furunculosis, erysipelas for ointment.

Lincomycin in dentistry

Dentists call Lincomycin one of the best remedies for the treatment of inflammatory and purulent processes, because it quickly stops the destructive process in teeth and helps tissues heal. The active substance accumulates in the tissues of teeth and gums. Indications for use in dentistry are the following diseases:

  • periodontitis;
  • ulcerative gingivitis;
  • inflammation of periodontal tissues;
  • purulent infections, abscesses;
  • suppuration in periodontal pockets;
  • stomatitis;
  • osteomyelitis;
  • periodontitis.

A special form of Lincomycin, Dental, has been released especially for dentists. It is a film impregnated with medicine, which is glued to parts of the oral cavity for an antibacterial effect. It lasts a long time and can be used by patients independently. Lincomycin injections are used in the treatment of restoration of destroyed bone tissue, ointment to relieve bleeding and inflammation of the gums (at night after brushing your teeth). The ointment can also be used to treat herpes and lubricate tooth areas while wearing braces.

Directions for use and dosage

According to the instructions, the method of use and dosage depend on the chosen format of the medicine and the severity of the disease. The medication is prescribed by a doctor, and the course and regimen are prescribed. Tablet dosage regimen: 500 mg three times a day. The dosage can be increased to 500 mg in four doses, the course lasts 1-2 weeks. The dose is adjusted depending on age and the presence of renal or hepatic impairment.

Lincomycin in ampoules

According to the instructions, the ampoule solution is prescribed to children from one month old; younger than this age, the drug is not used. The drug is administered intravenously in the following dosage:

  • under the age of 14 years – mg/kg every 8-12 hours;
  • adults - intravenous Lincomycin 600 mg in 250 ml of physiological solution of sodium chloride or glucose, frequency - 2-3 times a day; for severe infections, injections of Lincomycin 600 mg 1-2 times a day are given intramuscularly.

Pills

Tablets are intended for oral administration. They are consumed orally 1-2 hours before meals or 2-3 hours after. It is necessary to take Lincomycin capsules with plenty of clean water. Frequency of application – 2-3 times/day with an interval of 8-12 hours. Instructions for use contain the following dosage recommendations:

  • children aged 3-14 years – mg/kg/day;
  • adults – single dose 500 mg, maximum daily dose is 1-1.5 g, frequency 3-4 times/day;
  • angina is treated for 10 days; when treating the disease, you can combine taking pills and intravenous administration of a solution to eliminate the effects of microorganisms on the heart and lungs.

According to the instructions, Lincomycin ointment is applied externally. It is applied directly to the affected area in a thin layer for skin diseases, repeating the procedure two or three times a day. This form of medication can be used with caution in children older than one month due to the increased risk of allergic dermatitis; for adults, use for the treatment of skin infections is carried out as usual.

special instructions

The instructions for use indicate special instructions that must be followed when using the drug:

  • for patients suffering from impaired liver and kidney function, the single dose is reduced by half or by a third, while the interval between use is increased;
  • with the development of pseudomembranous colitis, Lincomycin is canceled and replaced with Vancomycin or Bacitracin;
  • Medication therapy is carried out with caution if patients have allergic reactions, bronchial asthma, colitis, or a history of gastrointestinal diseases;
  • not used to treat meningitis.

Lincomycin during pregnancy

The instructions say that Lincomycin crosses the placental barrier and is found in breast milk, so its use during pregnancy and breastfeeding is strictly prohibited (it can cause mastitis). During lactation, if the mother needs to undergo therapy with Lincomycin, breastfeeding is canceled for the entire period of therapy plus the time needed to remove the remaining active substance from the body.

Drug interactions

The drug may have an effect on other medications. Such interactions are described in the instructions for use:

  • penicillins, cephalosporins, chloramphenicol, erythromycin can cause antimicrobial antagonism;
  • aminoglycosides lead to synergistic action;
  • agents for inhalation anesthesia and anesthesia, muscle relaxants enhance neuromuscular blockade until apnea develops;
  • antidiarrheal drugs reduce effectiveness;
  • the medication is incompatible with ampicillin, barbiturates, theophylline, calcium gluconate, heparin, magnesium sulfate;
  • Kanamycin and novobiocin cannot be combined in one injection syringe or dropper.

Alcohol compatibility

The drug is incompatible with ethanol; alcohol slows down the absorption of the drug in the gastrointestinal tract, has a negative effect on the liver, increasing the half-life of the drug and increasing the load on the organ. Alcohol-containing drinks or medications when combined with Lincomycin reduce the effectiveness of the medication and increase the risk of negative side effects.

Side effects

According to the instructions, the drug can cause the following side effects that will cause discomfort to the patient:

  • nausea, diarrhea, stomatitis, glossitis;
  • reversible leukopenia (decreased white blood cells);
  • urticaria, allergic reactions, dermatitis;
  • candidiasis, phlebitis;
  • intestinal dysbiosis, which can lead to erosive damage to its walls;
  • impaired coordination of movements;
  • decreased blood pressure, dizziness, weakness, relaxation of skeletal muscles.

Overdose

According to reviews and instructions for use, no consequences were observed after an overdose of the drug. If you take the medicine orally for a long period of time in large doses, you may develop pseudomembranous colitis and candidiasis infection. If signs of these diseases appear, treatment should be stopped and consult a doctor. Hemodialysis and peritoneal dialysis are not effective in removing the active substance from the blood.

Contraindications

The instructions indicate the following contraindications, in the presence of which the use of the drug is strictly prohibited due to unwanted side effects and harm to health:

  • severe renal and liver dysfunction;
  • pregnancy, breastfeeding;
  • hypersensitivity to components, clindamycin;
  • children up to a month for solution and ointment, up to three years for tablets, up to five years for dental use;
  • fungal diseases (the drug is not effective against fungal pathogens), fungal or viral tonsillitis.

Terms of sale and storage

All types of medicine are sold in pharmacies with a prescription. The drug is stored in a dry, dark place away from children at a temperature of 0 degrees. The shelf life for the ointment is two years, for all other forms of release - four.

Analogs

Based on the active substance of the composition and the therapeutic effect provided, the following analogs of the drug are distinguished, produced in the form of tablets, solution and ointment by domestic and foreign pharmaceutical companies:

The cost of the drug depends on what form of medicine the doctor prescribed to the patient, the number of ampoules or tablets in the package and the trade markup. Approximate prices in Moscow are shown in the table:

Pharmacy prices, rubles

Ampoules 10 pcs. 1 ml each

Ampoules 5 pcs. 2 ml each

Video

Reviews

Vitaly, 34 years old

Last year, the doctor prescribed me Lincomycin for a sore throat - I had a severe course of the disease, complicated by purulent discharge on the tonsils. The antibiotic helped almost instantly, relieved inflammation and pain when swallowing, plus prevented the disease from affecting serious organs. According to the reviews I read, this is the most effective drug for treating sore throat.

I caught a cold after being caught in the rain and treated myself at home, but the cough did not go away and I developed chest pains. I got scared and went to the doctor. He diagnosed bronchitis and prescribed medicine. It became Lincomycin for bronchitis in capsules. I drank them strictly according to the instructions, took them every day, and within a week I managed to reduce the symptoms and alleviate the condition.

The child was diagnosed with stomatitis, which he caught from unwashed hands. The dentist recommended a special drug, Dental Lincomycin, to heal the ulcers. I've never heard of this, but the doctor told me that it is only for dental problems. It’s easy to use – just stick a film on the sores and wear them until they fall off.

I caught a cold and ended up in the hospital with pneumonia. It was painful and unpleasant, but the doctors quickly got me back on my feet, putting me on drips with the antibiotic Lincomycin. After the danger was relieved, I was discharged home and was also prescribed capsules of the drug. I drank them for a week, after which I restored my immunity and lung health.

The information presented on the site is for informational purposes only. The site materials do not encourage self-treatment. Only a qualified doctor can make a diagnosis and make recommendations for treatment based on the individual characteristics of a particular patient.

Source: http://vrachmedik.ru/656-linkomicin-instrukciya-po-primeneniyu.html

Lincomycin

Description current as of 12/02/2014

  • Latin name: Lincomycin
  • ATX code: J01FF02
  • Active ingredient: Lincomycin (Lincomycin)
  • Manufacturer: Sintez OJSC, Russia

Compound

The antibiotic Lincomycin contains the active substance lincomycin and a number of auxiliary ingredients.

The composition of Lincomycin-AKOS ointment includes lincomycin, which is in the form of hydrochloride.

Release form

The release form of the drug is capsules and solution contained in ampoules. The package can contain 6, 10 and 20 capsules of 250 mg each. Ampoules can contain 1 ml or 2 ml of solution.

Lincomycin-AKOS ointment is sold in tubes of 10 and 15 g.

pharmachologic effect

An antimicrobial agent that belongs to the group of lincosamides. Its bacteriostatic effect is noted in relation to a wide range of microorganisms. If higher doses of the drug are used, it may produce a bactericidal effect.

The mechanism of the antimicrobial effect of the antibiotic is as follows: under its influence, protein synthesis is inhibited in the cells of microorganisms. It has pronounced activity against gram-positive anaerobic and aerobic microorganisms. Resistance to the influence of the drug is demonstrated by strains of Enterococcus faecalis, as well as viruses, fungi, and protozoa. Most gram-negative microorganisms are also resistant to it. Slow development of resistance to this drug has been noted. Cross-resistance of this substance with clindamycin has been noted.

Pharmacokinetics and pharmacodynamics

After oral administration, lincomycin hydrochloride is rapidly absorbed from the gastrointestinal tract. About 50% of the substance enters the systemic circulation. It is 75% bound to plasma proteins, the highest concentration is observed 2-4 hours after oral administration. The substance penetrates into fluids and organ tissues. The highest concentrations are observed in saliva, kidneys, genitals, liver, heart muscle, bone tissue, and bronchial secretions. Able to penetrate the blood-brain barrier, it is excreted in breast milk. Metabolism mainly occurs in the liver, it is excreted from the body in feces, a small amount is also excreted in the urine as metabolites and unchanged. The half-life of the body is hours, it increases in people suffering from kidney disease.

Indications for use of Lincomycin

Lincomycin tablets and Lincomycin injections are prescribed for the following diseases:

  • diseases of the bones and joints of an infectious nature, the development of which was provoked by microorganisms sensitive to the drug (osteomyelitis, septic arthritis);
  • infectious diseases of the ENT organs and respiratory tract, provoked by sensitive microorganisms (used for sore throat, sinusitis, otitis media, bronchitis, pneumonia, tracheitis, etc.);
  • diseases of the skin and soft tissues that are provoked by microorganisms sensitive to the product (abscess, purulent wounds, mastitis, furunculosis, erysipelas, etc.).
  • Lincomycin-AKOS is used externally for inflammatory and purulent diseases of soft tissues and skin, which were caused by microorganisms sensitive to the active ingredient.

Lincomycin is used in dentistry to treat purulent and infectious processes that occur in the oral cavity. In particular, Lincomycin in dentistry can be prescribed for the treatment of periodontitis, periodontitis, gingivitis, purulent abscesses, etc. Whether there are indications for the use of Lincomycin is determined by the dentist individually.

Contraindications

This drug should not be used during therapy by people who are highly sensitive to antibiotics belonging to the lincosamide group. Not used to treat patients suffering from severe kidney and liver diseases. Not used to treat children under 6 years of age.

Side effects

When using Lincomycin in ampoules and capsules, patients may experience the following side effects:

If you experience any side effects, you should immediately tell your doctor about it.

Instructions for use of Lincomycin (Method and dosage)

If the patient has been prescribed Lincomycin injections, the instructions for use must be carefully followed during the treatment process. The drug in ampoules can be administered intravenously and intramuscularly. The daily dose of the drug for an adult patient should be no more than 1.8 g; if the disease is severe, the doctor can increase it to 2.4 g. The drug is administered three times a day, with the interval between injections being 8 hours. For children, the drug should be administered in a dose of mg per 1 kg of body weight per day. Lincomycin is administered intravenously by drip; before administration, the solution is diluted with an isotonic sodium chloride solution.

For infectious diseases, Lincomycin capsules are also prescribed. The instructions for use recommend taking the drug in capsules for sore throat, as well as for sinusitis, either 1 hour before a meal, or 2 hours after taking it. The tablets cannot be chewed, they must be swallowed whole with plenty of liquid. The drug in tablets should be taken at regular intervals, dividing its daily dose. For children whose body weight exceeds 25 kg, the daily dose should be determined at the rate of 30 mg of the drug per 1 kg of weight.

When using the medicine in dentistry, as well as in the treatment of other infectious diseases, as a rule, Lincomycin is prescribed 500 mg three times a day. For severe symptoms, the dose can be increased to 500 mg of the drug four times a day. As a rule, the course of treatment lasts from 1 to 2 weeks. Sometimes the duration of treatment is up to 3 weeks (for example, with osteomyelitis). If the patient has liver or kidney dysfunction, the dose should be adjusted individually.

Lincomycin ointment is prescribed externally. The instructions for use indicate that Lincomycin-AKOS ointment should be applied directly to the affected area in a thin layer. This procedure must be done 2-3 times a day.

Overdose

There are no data on cases of acute overdose of the drug. If taken over a long period and in large doses, pseudomembranous colitis and candidiasis may occur. In this case, treatment with the drug should be suspended.

Interaction

If an antibiotic is used at the same time as non-steroidal anti-inflammatory drugs, the patient is more likely to develop respiratory failure and may experience respiratory arrest.

Taking Lincomycin and antidiarrheals simultaneously increases the likelihood of developing pseudomembranous colitis.

You cannot treat with the drug at the same time as using muscle relaxants and inhalational anesthetics.

Antibiotic absorption is reduced when taking adsorbent drugs simultaneously.

Terms of sale

The drug is sold by prescription.

Storage conditions

The drug in the form of a solution, capsules and ointment should be stored in a dry and dark place, the temperature should be degrees Celsius.

Best before date

The drug can be stored for 4 years. The shelf life of Lincomycin-AKOS is 2 years.

special instructions

If the patient has impaired renal or liver function, the single dose of the drug is reduced by 1/3-1/2, and the interval between administration is increased. With prolonged antibiotic treatment, the condition of the liver and kidneys must be monitored.

If the patient has renal or liver failure, the drug is contraindicated, for which Lincomycin can be prescribed exclusively for health reasons.

If a patient is prescribed Lincomycin tablets, which subsequently develops pseudomembranous colitis as a side effect, the drug is discontinued and Bacitracin or Vancomycin is prescribed.

Externally, the ointment is carefully prescribed for dermatomycosis.

The solution should not be administered rapidly intravenously

Analogs

The use of other drugs by patients prescribed Lincomycin without the prior approval of a physician is strictly prohibited.

For children

It is allowed to prescribe antibiotics to children after reaching 6 years of age.

With alcohol

When discussing the compatibility of this antibiotic with alcohol, it should be noted that alcohol should not be consumed while being treated with this medicine. This combination will disrupt the absorption of the active substance of the drug in the gastrointestinal tract; under the influence of alcohol on the liver, an acceleration of the half-life of the active substance is observed. Consequently, the concentration of the drug in the body decreases, and its effectiveness decreases.

In addition, if a patient combines Lincomycin and alcohol, the consequences can be negative, as the likelihood of side effects increases.

During pregnancy and lactation

During pregnancy and breastfeeding, the drug cannot be used for treatment. It is permissible to prescribe the medicine in the second and third trimesters of pregnancy, but only if vital signs are present.

Reviews about Lincomycin

Reviews of Lincomycin that users leave online indicate that this drug has a pronounced antimicrobial effect and allows you to quickly get rid of the unpleasant symptoms of infectious diseases. Those who have used Lincomycin injections also leave mostly positive reviews.

Both when administered intravenously and intramuscularly, the solution acts quickly and reduces the severity of symptoms. Reviews about the use of the product in dentistry often contain information that the drug helped to quickly get rid of purulent and inflammatory diseases.

Lincomycin price, where to buy

The price of Lincomycin in ampoules averages from 40 rubles for 10 ampoules of 1 ml.

The price of Lincomycin tablets ranges from 60 to 90 rubles for 20 pieces. You can buy the drug in capsules in Ukraine for an average of 25 UAH. (30 pcs.).

Lincomycin-AKOS ointment can be purchased at a price of 27 rubles.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Ukraine Ukraine
  • Online pharmacies in Kazakhstan Kazakhstan

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BIOSPHERE

Education: Graduated from Rivne State Basic Medical College with a degree in Pharmacy. Graduated from Vinnitsa State Medical University named after. M.I. Pirogov and internship at his base.

Work experience: From 2003 to 2013 – worked as a pharmacist and manager of a pharmacy kiosk. She was awarded diplomas and decorations for many years of conscientious work. Articles on medical topics were published in local publications (newspapers) and on various Internet portals.

My sister says that she was prescribed lincomycin for cystitis, but I can’t even believe it - there are no such indications. In general, it seemed to me that everyone had been treated with one monural for a long time, but she came across some very elderly doctor. Maybe, from the perspective of his experience, he is right.

Can you inject lincomycin at the same time as actovegin?

The periosteum under my crown became inflamed. The surgeon injected me with lincomycin. The tumor is all over my cheek. Is this a reaction or is there something wrong.

Tanya: I always use this remedy after a cold, because without it I can go a long time.

Zina: Export helped me with constipation. In addition, I developed dysbacteriosis. Fine .

German: prescribed by a proctologist. After a course (15 tablets), weeping appeared on the legs along the toes.

Ekaterina: Since childhood, when I worry, my stomach shrinks and becomes a lump, and then it hurts.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/linkomitsin