Lazolvan in injections

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Lazolvan - solution, tablets, syrup and ampoules for the treatment of bronchitis and cough. General description of the drug.

Lazolvan (ambroxol) is one of the most popular drugs for treating dry cough and alleviating its symptoms.

Table of contents:

Having a sufficient number of dosage forms, this drug is very convenient to use.

Before you continue reading: If you are looking for an effective method of getting rid of a runny nose, pharyngitis, tonsillitis, bronchitis or colds, then be sure to look at this section of the site after reading this article. This information has helped so many people, we hope it will help you too! So, now back to the article.

Medicines intended for the treatment of cough are divided into two types: those that help thin mucus in the pulmonary tract and those that promote easy expectoration.

A cough most often occurs simultaneously with a cold. It may not be strong and may occur simultaneously with a general illness. Against the background of more serious diseases (for example, bronchitis), the cough is quite strong and intrusive, causing discomfort in the patient. In this situation, it is necessary to take medications that dilute sputum, that is, relieving a dry cough. Lazolvan belongs to this type of medicine.

Popular dosage forms of the drug:

  • solution used for inhalation and oral use;
  • pills;
  • syrup;
  • ampoules.

Use of the drug

The drug Lazolvan is used for various diseases that are usually accompanied by the formation of viscous sputum in the respiratory tract. These diseases can be both acute and chronic:

  • bronchitis (acute and chronic form);
  • pneumonia (pneumonia);
  • chronic pulmonary disease (obstructive);
  • bronchial asthma, which is accompanied by difficulty clearing mucus from the respiratory tract;
  • bronchiectasis.

It is also possible to stimulate intrauterine lung maturation in a child with a possible threat of premature birth or the need for artificial birth in the period between 28 and 34 weeks of pregnancy using the drug Lazolvan. Use is also possible for the prevention and treatment of postpartum respiratory syndrome in newborns and premature infants.

The drug Lazolvan is a mucolytic agent. Ambroxol, which is part of the drug, helps increase the secretion of mucus in the pulmonary canals.

After which the symptoms of a dry cough improve, the mucus begins to be coughed up much easier, as the viscosity of the sputum significantly decreases. When Lazolvan is taken orally, the effect occurs within half an hour. However, the most rapid effect occurs when the drug is administered intravenously or intramuscularly; the effect persists for a fairly long period of time (6-10 hours).

Pharmacokinetics of the active substance

The substance ambroxol, which is part of Lazolvan, is actively and quickly absorbed in the gastrointestinal system of the body. Its concentration in the blood plasma reaches its maximum value after approximately 0.5 - 3 hours. About 90% of the substance binds to proteins in the blood plasma.

The highest concentration of the active substance is observed in lung tissue. Ambroxol is distributed between the blood and tissues quite quickly. It does not accumulate in tissues and is practically eliminated from plasma within twelve hours.

Processed by the liver and excreted by the kidneys (90% processed).

Tablets Lazolvan

Lazolvan tablets are a pronounced mucolytic agent that helps improve the removal of mucus from the respiratory canals.

The tablets are flat, round, light lemon-colored or completely colorless. On one side, the Lazolvan tablet has a notch that divides it in half; on the other side, there is a trademark of the manufacturer.

Composition: one tablet of Lazolvan contains ambroxol hydrochloride weighing 30 mg - the active substance;

- corn starch (dried), lactose, colloidal silicon and magnesium stearate - excipients.

Lazolvan tablets are available in packs of 25 or 50 pieces. Tablets are one of the most convenient dosage forms to use.

The tablets should be taken orally after meals with water, juice or tea. Drinking plenty of fluids is recommended.

This drug Lazolvan is prescribed only to adults and children over 12 years of age. It is recommended to take a whole tablet no more than three times a day in the first days of treatment, and then one tablet twice a day or half a tablet three times a day. With a special prescription from a doctor, it is possible to increase the therapeutic effect by increasing the number of Lazolvan tablets taken simultaneously: two tablets no more than twice a day.

The attending physician can prescribe Lazolvan tablets to children aged from 6 to 12 years: it is recommended to take half a tablet no more than three times a day.

If symptom relief does not occur within five days, then consultation with a specialist is necessary.

Extended release capsules

Long-acting capsules contain a daily dose of the active substance – ambroxol. Lazolvan capsules act quite effectively and quickly, due to the content of a large number of microgranules in them. These granules create a concentration of ambroxol in the blood - the most therapeutically effective. The effect is achieved quickly and lasts for a long time.

One capsule of the drug Lazolvan is equivalent in composition to three tablets (75 mg of ambroxol), therefore it is prescribed to adults once a day.

Since intensive sputum discharge is observed after taking the Lazolvan capsule, it is recommended to take it in the morning to ensure a restful sleep. It is recommended to take capsules after meals, swallowing completely without chewing.

If after taking the capsules there is no improvement in symptoms within 14 days, you should consult a specialist.

Lazolvan syrup

The drug Lazolvan syrup has a double effect: it relieves irritation in the pulmonary canals and thins mucus, facilitating its removal.

Lazolvan syrup contains 30 mg of ambroxol per 5 ml - this is the active substance. It also contains other excipients: glycerin, sorbitol, hydroxyethyl cellulose, sodium saccharin, orange essence, menthol, apricot flavor and purified water.

The consistency of the syrup is thick, viscous, almost colorless and has a pleasant fruity smell and taste. Available in dark brown glass bottles complete with a measuring spoon.

Syrup is prescribed for any acute respiratory disease of the pulmonary canals and at the initial stage during the treatment of chronic respiratory diseases. The syrup does not contain alcohol and is suitable for diabetics.

In case of illness, Lazolvan syrup (30 mg of active substance in 5 ml of the drug) is prescribed:

— it is recommended for children over 6 and under 12 years of age to take 2.5 ml (or half a teaspoon) no more than three times a day;

— it is recommended for children over 12 years of age and adults to take 10 ml no more than three times a day during the first 3 days of illness, then 5 ml no more than three times a day. If the disease is severe, the dose is not reduced throughout the course.

Lazolvan syrup is taken with meals. Take with the required amount of any liquid.

Syrup for children

The drug Lazolvan syrup for children contains the active substance ambroxol in the amount of 15 mg in a volume of 5 ml. This is an absolutely safe dose for treating young children.

Syrup for children is produced in amber-colored glass bottles, complete with a measuring spoon.

Ambroxol in Lazolvan has mucolytic, antioxidant and anti-inflammatory properties, which is ideal for the treatment of diseases in the pulmonary ducts in children. Children's Lazolvan has a pleasant smell and taste, so children usually take it without any problems.

Lazolvan syrup 15 mg is taken in a volume of 5 ml during meals. Take the required amount of any liquid.

Prescription of syrup for children is made only by the attending physician based on the indications of the disease for children aged at least 1 year. Children's Lazolvan according to the instructions is taken as follows:

— it is recommended for children aged from one to two years to take 2.5 ml of the drug (half a teaspoon) no more than twice a day;

— it is recommended for children aged 2 to 6 years to take 2.5 ml of the drug no more than three times a day;

— it is recommended for children aged 6 to 12 years to take 5 ml of the drug (one teaspoon) no more than three times a day;

— it is recommended for children over 12 years of age to take 10 ml of the drug (two teaspoons) no more than three times a day.

The drug Lazolvan for children in syrup works for quite a long time, so the number of doses can be reduced. If you want to use an effective remedy to treat your child, which will also be safe, then it makes sense to use this medicine. Instructions for use of the drug indicate the qualitative effect of Lazolvan in the fight against diseases of the respiratory tract.

Lazolvan solution

The dosage form Lazolvan solution can be used both for oral administration and for inhalation.

The Lazolvan solution contains ambroxol, an active substance (7.5 mg in a volume of one ml). Other auxiliary ingredients are sodium chloride, purified water, citric acid and others.

The solution is produced in 100 ml bottles made of amber glass; the set includes a beaker.

Lazolvan solution and instructions for use:

The dosage of Lazolvan solution in one ml is equal to 25 drops.

According to the instructions, the solution is prescribed:

- children under two years of age take 25 drops or 1 ml of solution no more than twice a day;

- children aged from two to six years take 25 drops of solution or 1 ml no more than three times a day;

- children over six years old take 50 drops of solution or 2 ml no more than three times a day;

— adults take 4 ml of solution no more than three times a day at the beginning of the course of treatment.

The solution should be diluted in water, milk, juice or taken with meals.

Lazolvan solution for inhalation and instructions:

It is known that for the treatment of various respiratory diseases, inhalation is one of the fastest and most effective methods. During inhalation, a person inhales medicinal substances that act on the mucous membrane of the pulmonary tract. Medicinal substances act faster and more effectively on the mucous membrane, so healing takes less time.

Lazolvan for inhalation according to the instructions is used as follows:

- adults and children over 6 years of age are recommended to inhale no more than twice a day, using 2-3 ml of Lazolvan solution per inhalation;

— children under six years of age are recommended to inhale no more than twice a day, using only 2 ml of solution.

How to do inhalations with Lazolvan correctly?

Lazolvan inhalation solution can be used with any inhalation device except a steam inhaler. Lazolvan is diluted with physiological solution (for example, sodium chloride 0.9%) in a one to one ratio, thereby achieving optimal air humidification during inhalation. The solution for inhalation must be warmed to body temperature.

It is recommended to do inhalations one and a half to two hours after eating. Inhalation is done with concentration and without distraction. There is no need to take deep breaths, as this can provoke coughing attacks. Inhalation takes place in calm breathing mode. Afterwards, you should not eat or talk for a long time for an hour.

The duration of children's inhalation with Lazolvan is up to three minutes, it is recommended to do them 1-2 times a day. The course of treatment is no more than five days.

For effective inhalation you need a good inhaler. How to choose the right inhaler for inhalation? - a very useful article, don’t be lazy to read! This article also explains how to do inhalations and many other important and interesting nuances.

Special instructions when using the drug in the form of an inhalation solution:

— if a patient has bronchial asthma, inhalation with Lazolvan solution is recommended only after mandatory intake of bronchodilators in order to minimize the risk of irritation and spasms of the respiratory tract;

— it is not recommended to carry out inhalations at elevated body temperatures (more than 37.5 degrees);

— inhalations are contraindicated for frequent nosebleeds;

— in the presence of respiratory and cardiovascular failure, only a specialist can prescribe inhalations with Lazolvan.

- for long-term use of the inhalation solution (more than five days), the prescription is made by a doctor.

The drug Lazolvan in ampoules

The drug Lazolvan in ampoules has proven its effectiveness in the fight against the most severe diseases of the pulmonary tract.

Lazolvan in ampoules is a colorless transparent solution, without impurities. The composition includes ambroxol 15 mg, citric acid, water for injection, sodium chloride, benzalkonium chloride.

Method of using Lazolvan in ampoules:

The drug Lazolvan is administered intravenously (using syringes or droppers), intramuscularly or subcutaneously.

Adults are recommended to take 15 mg (one ampoule of the drug Lazolvan), administered no more than three times a day. If there are indications of severe illness, the dosage can be increased to 30 mg (simultaneous administration of two ampoules).

For children, the drug is prescribed based on body weight: the recommended dose is no more than 1.6 mg per kg no more than three times a day. Lazolvan is usually recommended for children:

- age up to two years - dosage 7.5 mg (half an ampoule) no more than twice a day;

- age from two to 5 years - dosage 7.5 mg (half an ampoule) no more than three times a day;

- age over 5 years - dosage of 15 mg of Lazolvan (one ampoule of the drug) no more than three times a day.

It is possible to treat postpartum respiratory syndrome of prematurity and newborns with Lazolvan. The drug is administered intramuscularly or intravenously at a dosage of 10 mg per kg of body weight per day (administered no more than four times and only as prescribed by a doctor). If necessary, the dose is increased: it is possible to take 30 mg per kg of body weight per day.

For administration, the injection solution is diluted using droppers: 50 ml of the drug is diluted in a physiological base solution of 500 ml. The following solutions can be used: sodium chloride solution (0.9%), Ringer-Locke solution, dextrose solution or another base solution with a pH of no more than 6.3. The drug is administered for about two hours, the rate of administration is 84 drops per minute.

The administration of the drug Lazolvan in ampoules is stopped with the disappearance of acute indications of the disease. Further treatment is recommended to be carried out by taking the drug orally (tablets, solution or syrup).

If, after a course of treatment with Lazolvan, the indications persist, then a repeat treatment regimen can be carried out after two weeks.

Special instructions: with rapid intravenous administration of the drug Lazolvan, weakness in the legs, fatigue and headaches may occur.

The physiological solution with which Lazolvan injection solution is mixed should not have a pH higher than 6.3, because after this a precipitate of free Lazolvan may form.

In severe forms of the disease, a combination of inhalation therapy and administration of the drug Lazolvan in ampoules gives the best results.

Side effects. Overdose. Contraindications

  • various allergic reactions: skin rashes, urticaria, itching;
  • headache, feeling of weakness;
  • unpleasant sensations (dryness, tickling) in the respiratory canals;
  • dry mouth, stomach pain, constipation;
  • nausea and vomiting;
  • anaphylactic shock, edema (angioneurotic).

Note that when taking the drug Lazolvan, side effects were observed rarely enough to indicate a high probability of their occurrence.

Nausea, vomiting and stomach pain are often observed with very long-term use in doses higher than those recommended in the Lazolvan annotation. A sharp decrease in blood pressure, weakness, shortness of breath, headaches, chills are observed with rapid intravenous administration of the drug.

The first symptoms of an overdose are diarrhea, nausea and vomiting. Recommended treatment: induce vomiting, gastric lavage in case of large overdose within the first two hours and intake of foods high in fat. Follow your doctor's instructions carefully when taking Lazolvan.

The main contraindications for taking Lazolvan are special sensitivity to its composition.

There were no contraindications for the use of the drug Lazolvan during pregnancy and breastfeeding. But it is recommended to take into account the undesirability of taking medications during the first trimester.

The drug easily passes into breast milk, but no negative effects on the baby have been identified. All drug prescriptions for pregnant and lactating women are made by a doctor, taking into account all possible risks.

Special instructions. Interaction with other drugs

The drug Lazolvan should not be combined with drugs whose action is aimed at suppressing cough. This will greatly complicate the removal of sputum from the pulmonary tract, which can lead to negative consequences.

Lazolvan inhalation solution can be used using any modern inhalers, except for a steam inhaler. For patients with bronchial asthma, it is recommended to take bronchodilators before the inhalation procedure to avoid spasm of the respiratory tract.

Patients with diabetes can take Lazolvan syrup because it does not contain sugar. The syrup also does not contain alcohol.

Lazolvan tablets contain lactose in the maximum daily dose, so for patients who suffer from individual galactose intolerance, Lapp deficiency (lactose) and impaired absorption of galactose and glucose, this drug is not recommended.

Animal studies have not revealed any negative effects of ambroxol on the fetus. Although this substance crosses the placenta. Clinical experience also did not reveal any negative effects of Lazolvan during pregnancy after 28 weeks. It is recommended to take the drug only as prescribed by a doctor. Use is not recommended in the first trimester of pregnancy.

It is also not recommended to take Lazolvan on your own during breastfeeding, since ambroxol can pass into breast milk. No negative effects on the child have been identified, but in this case it is necessary to weigh the risk against the benefit.

Children under 12 years of age are not recommended to take Lazolvan tablets and extended-release capsules. It is recommended to take the drug in drops, a syrup option and an inhalation option. It is also not recommended to use Lazolvan 15 mg suppositories for children for children under 5 years of age, and for children under 12 years of age - Lazolvan 30 mg.

Sometimes you can see remnants of gelatin capsules in the stool, but this does not indicate the low effectiveness of the drug. The active substance is released during passage through the gastrointestinal tract.

Interaction of Lazolvan with other drugs:

Concomitant use with antibiotics (for example, erythromycin, cefuroxime, amoxicillin, dioxycycline) leads to the effect of increasing the concentration of these antibiotics in the lung tissues. This property has been successfully used for effective antibiotic treatment.

The interaction of the drug Lazolvan with antitussives leads to difficulties in sputum discharge as a result of suppression of the cough reflex.

When using the drug Lazolvan injection solution, it should be taken into account that it cannot be mixed with solutions with a pH greater than 6.3. In this case, the possibility of precipitation of free Lazolvan increases.

There are no experimental data indicating special interactions with other drugs.

Directions for use, storage of the drug and expiration date

Lazolvan preparations are stored at a temperature of no more than 25 degrees in places closed from direct access to children.

It is recommended to protect the drug from heat, frost and direct sunlight.

Shelf life of the drug from the date of manufacture (indicated on the packaging):

  • tablets for no more than 5 years;
  • syrup for children no more than three years old;
  • regular syrup no more than 5 years;
  • solution no more than 5 years;
  • Lazolvan in ampoules for no more than three years.

The drug Lazolvan is dispensed from the pharmacy without a doctor's prescription.

The main purpose of the cough reflex is to clear the airways of mucus (phlegm), fluids, or any foreign bodies. Coughing refers to the protective functions of the body and is aimed at clearing the air passages from absorbed substances or from secret phlegm secreted in the respiratory canals.

With the cough reflex, the muscles of the respiratory system contract and a sharp, powerful release of air begins from the lungs. A cough begins to occur when the sensory nerve endings that are located in the organs of the respiratory system (larynx, trachea, bronchi, pleura) are irritated.

The use of any medications designed to help fight cough must be justified. It is recommended that it be prescribed only by the attending physician, who, according to indications, will determine the causes of cough and prescribe the recommended treatment. If you use the wrong combination of medications to combat the cough reflex, serious side effects can occur. In particular, blockage of the bronchi with secreted mucus may occur, since it will not be naturally removed from the respiratory canals.

Your doctor will recommend you the dosage form of Lazolvan individually.

The article above and comments written by readers are for informational purposes only and do not encourage self-medication. Consult a specialist regarding your own symptoms and illnesses. When taking any medicine, you should always use the instructions that come with the medicine and your doctor's advice as a guide.

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Lazolvan

Instructions for use:

Latin name: Lasolvan

ATX code: R05CB06

Active ingredient: Ambroxol (Ambroxol)

Manufacturer: Bolder Arzneimittel GmbH & Co. KG (Germany), Instituto De Angeli (Italy), Boehringer Ingelheim Ellas (Greece), Delpharm Reims (France)

Description valid as of: 10.19.17

Price in online pharmacies:

Lazolvan is a mucolytic and expectorant intended for the treatment of diseases of the bronchi and lungs.

Active substance

Release form and composition

Lazolvan is available in the form of syrup, tablets and solution for inhalation.

Indications for use

The drug is used for the treatment of chronic and acute diseases of the respiratory tract, which are accompanied by the release of viscous sputum (pneumonia, bronchial asthma, bronchiectasis, chronic and acute bronchitis).

Children's Lazolvan is effective in the treatment of respiratory distress syndrome in premature infants and newborns.

Contraindications

Lazolvan should not be taken during pregnancy, or if you are sensitive to ambroxol or other components of the drug.

Also, the drug should be prescribed with caution during pregnancy, breastfeeding, and with renal and liver failure.

Instructions for use Lazolvan (method and dosage)

The drug in syrup form is taken orally, regardless of meals.

For adults and children over 12 years of age, Lazolvan syrup 15 mg/5 ml is prescribed 10 ml 3 times a day. Children under 2 years old - 2.5 ml 2 times a day. Children from 2 to 6 years old - 2.5 ml 3 times a day. Children from 6 to 12 years old - 5 ml 2-3 times a day.

For adults and children over 12 years of age, Lazolvan syrup 30 mg/5 ml is prescribed 5 ml 3 times a day. Children aged 6 to 12 years are prescribed 2.5 ml 2-3 times a day.

If signs of the disease persist for 4-5 days from the start of using the syrup, you should consult a doctor.

Lazolvan in tablet form is prescribed orally at a dose of 30 mg (1 tablet) 3 times a day. If necessary, to enhance the therapeutic effect, prescribe 60 mg (2 tablets) 2 times a day. You can take the tablets regardless of meals.

If signs of the disease persist for 4-5 days from the start of using the tablets, you should consult a doctor.

Solution. Oral administration (1 ml = 25 drops).

Drops can be diluted in water, tea, juice or milk. The solution can be used regardless of meals.

Adults and children over 12 years old - 4 ml (100 drops) 3 times a day; children aged 6 to 12 years - 2 ml (50 drops) 2-3 times a day; children aged 2 to 6 years - 1 ml (25 drops) 3 times a day; children under 2 years of age - 1 ml (25 drops) 2 times a day.

For adults and children over 6 years of age, lethalation is 2-3 ml of solution/day.

Children under 6 years of age: 2 ml of solution/day.

Side effects

Lazolvan is well tolerated. In some cases, the following side effects occur:

  • From the digestive system (with prolonged use of high doses of the drug): nausea, gastralgia, heartburn, vomiting.
  • Allergic reactions: angioedema, urticaria, skin rash; rarely - allergic contact dermatitis and anaphylactic reactions.

Overdose

Symptoms of overdose: nausea, diarrhea, vomiting, gastralgia, dyspepsia.

Treatment: induction of vomiting; in the first couple of hours after taking the drug, gastric lavage, symptomatic therapy and intake of fat-containing foods are recommended.

Analogs

Analogs by ATC code: Ambrobene, AmbroHEXAL, Ambrosol, Flavamed.

Do not decide to change the drug on your own; consult your doctor.

pharmachologic effect

The active ingredient of Lazolvan is Ambroxol hydrochloride. The drug has a mucolytic effect and also activates the removal of sputum from the body by stimulating the motor activity of the epithelial cilia of the bronchi and the activity of serous cells of the mucous membranes of the bronchi.

The therapeutic effect of Lazolvan appears after half an hour and can last for 6-12 hours.

special instructions

In patients with severe skin lesions in the early phase, cough and inflammation of the pharynx, fever, rhinitis, and body pain may occur.

There are isolated reports of the detection of toxic epidermal necrolysis and Stevens-Johnson syndrome, which coincided with the use of the drug. However, there is no cause-and-effect relationship with taking Lazolvan. If the above syndromes occur, it is advisable to stop therapy and seek medical help.

No cases of Lazolvan influencing the ability to drive vehicles and machinery have been identified.

During pregnancy and breastfeeding

The active ingredient of the drug can pass into breast milk, but there is no data on the harmful effects of the drug on the baby. Therefore, the decision on the advisability of using Lazolvan by a nursing mother is made by a doctor.

In childhood

For children and adolescents under 18 years of age, it is advisable to use other dosage forms of the drug (syrup, lozenges, solution for oral administration and inhalation).

In old age

No clinically significant effect of age on the pharmacokinetics of ambroxol was found. Therefore, there is no basis for selecting the dose based on these characteristics.

For impaired renal function

If kidney function is impaired, the drug should be used only on the recommendation of a doctor.

For liver dysfunction

The drug is prescribed with caution to people with liver failure.

Drug interactions

Lazolvan should not be prescribed simultaneously with antitussive drugs that impede the removal of sputum.

Conditions for dispensing from pharmacies

Available without a prescription.

Storage conditions and periods

Lazolvan syrup should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life: 3 years.

Lazolvan tablets should be stored out of the reach of children at a temperature not exceeding 30 °C. Shelf life: 5 years.

Price in pharmacies

Price Lazolvan for 1 package from 159 rubles.

The description posted on this page is a simplified version of the official version of the annotation for the drug. The information is provided for informational purposes only and does not constitute a guide for self-medication. Before using the medicine, you must consult a specialist and read the instructions approved by the manufacturer.

Lazolvan tablets 30 mg 20 pcs.

Lazolvan 15 mg No. 20 lozenges

Lazolvan 30 mg No. 20 tablets

Lazolvan tablets 30 mg n20

Lazolvan Max capsules 75 mg 10 pcs.

When using materials from the site, the active reference is obligatory.

The information presented on our website should not be used for self-diagnosis and treatment and cannot serve as a substitute for consultation with a doctor. We warn you about the presence of contraindications. Specialist consultation is required.

Source: http://dolgojit.net/lazolvan.php

Lazolvan

Instructions for use:

Prices in online pharmacies:

Lazolvan is a mucolytic and expectorant drug.

Release form and composition

  • Solution for oral administration and inhalation: transparent, colorless or with a slight brownish tint (100 ml in dark glass bottles equipped with a dropper, 1 bottle in a cardboard box complete with a measuring cup);
  • Syrup: slightly viscous, colorless or almost colorless, transparent or almost transparent, with the smell of wild berries or strawberries (100 or 200 ml in dark glass bottles, 1 bottle in a cardboard box complete with a measuring cap);
  • Tablets: flat on both sides, round, with beveled edges, white or with a yellowish tint, on one side - the company symbol, on the other - a separating line and engraving “67C” on both sides of it (10 pieces in blisters, in a cardboard box 2 or 5 blisters);
  • Lozenges: round, light brown, with the smell of peppermint (10 pieces in blisters, 1, 2 or 4 blisters in a cardboard pack).

The active ingredient of the drug is ambroxol hydrochloride:

  • 1 ml of solution – 7.5 mg;
  • 5 ml of syrup – 15 or 30 mg;
  • 1 tablet – 30 mg;
  • 1 lozenge – 15 mg.
  • Solution: sodium hydrogen phosphate dihydrate, benzalkonium chloride, citric acid monohydrate, sodium chloride, purified water;
  • Syrup: purified water, hyaetellose (hydroxyethylcellulose), benzoic acid, liquid sorbitol (non-crystallizing), acesulfame potassium, glycerol 85%, vanilla flavor, wild berry flavor PHL (in syrup 15 mg/5 ml) or strawberry-cream flavor PHL (in syrup 30 mg/5 ml);
  • Tablets: dried corn starch, lactose monohydrate, colloidal silicon dioxide, magnesium stearate;
  • Lozenges: acacia gum, sorbitol, liquid paraffin (purified mixture of liquid saturated hydrocarbons), carion 83 (mannitol, sorbitol, hydrolyzed hydrogenated starch), sodium saccharinate, purified water, oil of peppermint leaves and eucalyptus leaves.

Indications for use

Lazolvan is used to treat the following acute and chronic diseases of the respiratory tract, which are accompanied by impaired mucociliary clearance and the production of viscous sputum:

  • Bronchiectasis;
  • Acute and chronic bronchitis;
  • Chronic obstructive pulmonary disease;
  • Pneumonia;
  • Bronchial asthma with difficulty in sputum discharge.

Contraindications

For all dosage forms:

  • First trimester of pregnancy;
  • Breastfeeding period;
  • Hypersensitivity to ambroxol or auxiliary components.

Additional contraindications depending on the dosage form:

  • Syrup: children under 6 years of age (for syrup at a dose of 30 mg/5 ml), hereditary fructose intolerance;
  • Tablets: age under 18 years, lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
  • Lozenges: children under 6 years of age, hereditary fructose intolerance.

Lazolvan is used with caution in the second and third trimesters of pregnancy, as well as in case of renal and/or liver failure.

Directions for use and dosage

Lazolvan solution is intended for oral administration and inhalation.

You can take it orally, regardless of food intake; if necessary, dilute it in water, juice, tea or milk.

  • Children under 2 years old – 1 ml 2 times a day;
  • Children 2-6 years old – 1 ml 3 times a day;
  • Children 6-12 years old – 2 ml 2-3 times a day;
  • Children over 12 years of age and adults – 4 ml 3 times a day.

1 ml of solution = 25 drops.

For inhalation, Lazolvan can be used using any modern inhalation equipment, with the exception of steam inhalers. To achieve optimal hydration, the solution is mixed with 0.9% sodium chloride solution in a 1:1 ratio. Inhalations should be carried out in normal breathing mode, since deep inhalation can cause coughing. Before the procedure, it is recommended to warm the drug to body temperature.

Patients with bronchial asthma should inhale Lazolvan after taking a bronchodilator, otherwise nonspecific irritation of the respiratory tract and their spasm may occur.

  • Children under 6 years of age – 2 ml of solution per inhalation, 1-2 inhalations per day;
  • Children over 6 years of age and adults – 2-3 ml of solution per inhalation, 1-2 inhalations per day.

In the form of syrup, Lazolvan is taken orally, regardless of food intake.

Recommended doses for 15 mg/5 ml syrup:

  • Children under 2 years old – 2.5 ml 2 times a day;
  • Children 2-6 years old – 2.5 ml 3 times a day;
  • Children 6-12 years old – 5 ml 2-3 times a day;
  • Children over 12 years of age and adults – 10 ml 3 times a day.

Recommended doses for 30 mg/5 ml syrup:

  • Children 6-12 years old – 2.5 ml 2-3 times a day;
  • Children over 12 years of age and adults – 5 ml 3 times a day.

Lazolvan tablets should be taken orally with liquid, regardless of meals. The drug is prescribed 1 tablet 3 times a day. To enhance the therapeutic effect, you can take 2 tablets 2 times a day.

Lazolvan lozenges should be slowly dissolved in the mouth, regardless of food intake, children aged 6-12 years - 1 piece. 2-3 times a day, children over 12 years old and adults – 2 pcs. 3 times a day.

If symptoms of the disease persist after 4-5 days of treatment, you should consult a doctor.

Side effects

  • Digestive system: often (1-10%) – decreased sensitivity in the oral cavity or pharynx, nausea; uncommon (0.1-1%) – dry mouth, abdominal pain, diarrhea, vomiting, dyspepsia; rarely (0.01-0.1%) – dry throat;
  • Nervous system: often – disturbance of taste sensations;
  • Immune system, skin and subcutaneous tissues: rarely - rash, urticaria, itching, angioedema, hypersensitivity, anaphylactic reactions (including anaphylactic shock).

special instructions

The solution contains benzalkonium chloride as a preservative; when inhaled, it can cause bronchospasm in sensitive patients with increased respiratory tract reactivity.

Lazolvan should not be mixed with alkaline solutions and cromoglycic acid, since increasing the pH value of the solution above 6.3 can lead to precipitation of ambroxol or the appearance of opalescence.

Patients on a low-sodium diet should note that the oral and inhalation solution contains 42.8 mg sodium at the recommended daily dose for children over 12 years of age and adults (12 ml).

One Lazolvan tablet contains 162.5 mg of lactose, the maximum daily dose (4 tablets) is 650 mg.

Syrup Lazolvan 30 mg/5 ml in terms of the maximum daily dose (20 ml) contains 5 g of sorbitol, Lazolvan 15 mg/5 ml in the maximum daily dose (30 ml) - 10.5 g. Due to the sorbitol content, the syrup may have mild laxative effect.

Like any expectorant, Lazolvan should not be used simultaneously with antitussives that make it difficult to remove sputum.

Patients with severe skin lesions (eg, toxic epidermal necrolysis and Stevens-Johnson syndrome) may initially develop fever, rhinitis, body pain, sore throat, and cough. During symptomatic therapy, ambroxol hydrochloride may be prescribed erroneously. There are isolated reports of the detection of such severe lesions that coincided with the use of Lazolvan, but there is no cause-and-effect relationship with the drug. Therefore, if the described symptoms develop, you should stop treatment with ambroxol and immediately consult a doctor.

Studies have not been conducted on the effect of Lazolvan on a person’s ability to perform activities related to reaction speed and increased concentration. However, no cases of negative effects were identified.

Drug interactions

There have been no reports of clinically significant, undesirable interactions between ambroxol hydrochloride and other drugs.

Ambroxol enhances the penetration of erythromycin, amoxicillin and cefuroxime into the bronchial secretions.

Terms and conditions of storage

Store in a place protected from light and out of reach of children at temperatures: solution and syrup - up to 25 ºС, tablets and lozenges - up to 30 ºС.

The shelf life of the solution and tablets is 5 years, syrup and lozenges are 3 years.

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Lazolvan tablets 30 mg 20 pcs.

Lazolvan tab. 30mg n20

Lazolvan 15 mg No. 20 lozenges

Lazolvan 30 mg No. 20 tablets

Lazolvan tablets 30 mg n20

Lazolvan Max capsules 75 mg 10 pcs.

Lazolvan syrup 15 mg/5 ml 100 ml

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Lazolvan

Lazolvan: instructions for use and reviews

Latin name: Lasolvan

ATX code: R05CB06

Active ingredient: ambroxol (ambroxol)

Manufacturer: Instituto De Angeli (Italy), Boehringer Ingelheim Ellas (Greece), Bolder Arzneimittel GmbH & Co. KG (Germany), Delpharm Reims (France)

Update of description and photo: 08/29/2017

Prices in pharmacies: from 156 rubles.

Lazolvan is an expectorant and mucolytic drug.

Release form and composition

Lazolvan is produced in the following dosage forms:

  • Lozenges: round, light brown, with the smell of peppermint (in blisters of 10 pcs., 1, 2 or 4 blisters in a cardboard box);
  • Tablets: round, slightly yellowish or white, flat on both sides, with beveled edges, on one side there is a separating line and the inscription “67C” embossed on both sides of it, on the other - the company symbol (in blisters of 10 pcs., 2 or 5 blisters in a cardboard box);
  • Syrup: almost colorless or colorless, almost transparent or transparent, with the smell of wild berries (15 mg/5 ml each) or strawberry smell (30 mg/5 ml each), slightly viscous (in dark glass bottles of 100, 200 or 250 ml per complete with or without a measuring cup, 1 bottle in a cardboard box);
  • Solution for oral administration and inhalation: transparent, slightly brownish or colorless (in dark glass bottles of 100 ml, complete with a dosing cup or beaker, 1 bottle in a cardboard box).

The composition of 1 lozenge Lazolvan includes:

  • Active substance: ambroxol – 15 mg (in the form of hydrochloride);
  • Auxiliary components: acacia gum – 850 mg, sorbitol – 307.4 mg, carion 83 (mannitol, sorbitol, hydrogenated hydrolyzed starch) – 614.8 mg, peppermint leaf oil – 10 mg, eucalyptus leaf oil – 2 mg, saccharin sodium – 1.8 mg, liquid paraffin (purified mixture of liquid saturated hydrocarbons) – 2.4 mg, purified water – 196.6 mg.

The composition of 1 tablet Lazolvan includes:

  • Active substance: ambroxol – 30 mg (in the form of hydrochloride);
  • Auxiliary components: lactose monohydrate – 171 mg, dried corn starch – 36 mg, colloidal silicon dioxide – 1.8 mg, magnesium stearate – 1.2 mg.

The composition of 5 ml of Lazolvan syrup includes:

  • Active substance: ambroxol – 15 or 30 mg (in the form of hydrochloride);
  • Auxiliary components (15/30 mg per 5 ml, respectively): benzoic acid - 8.5/8.5 mg, hydroxyethylcellulose (hyetellose) - 10/10 mg, acesulfame potassium - 5/5 mg, liquid sorbitol (non-crystallizing) - 1750/1750 mg, glycerol 85% – 750/750 mg, vanilla flavor – 3/3 mg, purified water – 3047.5/3031.5 mg, wild berry flavor PHL – 11 mg (for syrup 15 mg/5 ml) or strawberry-cream flavor PHL – 12 mg (for syrup 30 mg/5 ml).

The composition of 1 ml of solution for oral administration and inhalation of Lazolvan includes:

  • Active substance: ambroxol – 7.5 mg (in the form of hydrochloride);
  • Auxiliary components: citric acid monohydrate - 2 mg, sodium hydrogen phosphate dihydrate - 4.35 mg, sodium chloride - 6.22 mg, benzalkonium chloride - 0.225 mg, purified water - 989.705 mg.

Pharmacological properties

Pharmacodynamics

Research data show that ambroxol, which is the active component of Lazolvan, causes an increase in secretion in the respiratory tract. As a result of exposure to the drug, the production of pulmonary surfactant and ciliary activity are enhanced. These effects stimulate the flow and transport of mucus (mucociliary clearance), resulting in intense mucus discharge and cough relief. In the treatment of chronic obstructive pulmonary disease during long-term therapy with Lazolvan (for 2 months or more), the number of exacerbations decreased significantly. A significant decrease in the duration of exacerbations and the number of days of antibiotic therapy was recorded.

Pharmacokinetics

All dosage forms of immediate release ambroxol are characterized by rapid and almost complete absorption (a linear dependence of absorption on dose is observed). When taken orally, the maximum concentration of ambroxol in plasma is achieved after 60–150 minutes. Distribution volume – 552 l. The binding of ambroxol to plasma proteins in the therapeutic concentration range is approximately 90%.

When administered orally, the transition of the active substance from the blood to the tissues occurs quickly. The highest concentrations of ambroxol are observed in the lungs. About 30% of an oral dose undergoes a first pass process through the liver. Studies on human liver microsomes have proven that the predominant isoform is the CYP3A4 isoenzyme. It is responsible for the metabolism of the active substance to dibromanthranilic acid. The remaining amount is metabolized in the liver, mostly by glucuronidation and through partial degradation (approximately 10%) to dibromoantranilic acid and additional metabolites in small quantities. The terminal half-life is 10 hours. Total clearance is up to 660 ml/min, with about 8% of the total clearance being renal clearance. In studies using the radioactive tracer method, it was calculated that as a result of taking a single dose of ambroxol over the next 5 days, approximately 83% of the dose taken is excreted in the urine.

A clinically significant effect of gender and age on the pharmacokinetics of ambroxol has not been recorded, so there is no reason to select the dosage based on these characteristics.

Indications for use

Lazolvan is prescribed for the treatment of the following acute and chronic diseases of the respiratory tract, which occur with the release of viscous sputum:

  • Bronchiectasis;
  • Pneumonia;
  • Bronchitis in acute and chronic course;
  • Bronchial asthma, occurring with difficulty in sputum discharge;
  • Chronic obstructive pulmonary disease.

Contraindications

  • First trimester of pregnancy and lactation period;
  • Hypersensitivity to the components of the drug.

Lazolvan should be used with caution in pregnant women in the second and third trimesters, as well as in those with renal and/or liver failure.

Children, depending on the dosage form of Lazolvan, can take:

  • Lozenges and syrup 30 mg/5 ml: from 6 years;
  • Tablets: from 18 years of age.

The lozenges, based on the maximum recommended daily dose (90 mg), contain 3200 mg of sorbitol, so patients with rare hereditary fructose intolerance should not take Lazolvan in this dosage form.

Lazolvan in tablet form is contraindicated for patients with lactase deficiency, lactose intolerance and glucose-galactose malabsorption.

Lazolvan syrup should not be taken by patients with hereditary fructose intolerance.

Instructions for use of Lazolvan: method and dosage

Lazolvan is used orally or inhaled.

The drug can be taken orally regardless of the time of meal.

Lozenges should be slowly dissolved in the mouth, tablets should be taken with liquid, the solution can be diluted in juice, tea, milk or water.

As a rule, Lazolvan is prescribed orally:

  • Lozenges: adults and children over 12 years old – 3 times a day, 2 lozenges; children 6-12 years old – 2-3 times a day, 1 lozenge;
  • Tablets: 3 times a day, 1 tablet; to enhance the therapeutic effect, it is possible to increase the daily dose (2 times a day, 2 tablets);
  • Syrup 15 mg/5 ml: adults and children over 12 years old – 3 times a day, 10 ml; children 6-12 years old – 2-3 times a day, 5 ml; children 2-6 years old – 3 times a day, 2.5 ml; children under 2 years old – 2.5 ml 2 times a day;
  • Syrup 30 mg/5 ml: adults and children over 12 years old – 3 times a day, 5 ml; children 6-12 years old – 2-3 times a day, 2.5 ml;
  • Oral solution (1 ml = 25 drops): adults and children over 12 years old – 3 times a day, 100 drops; children 6-12 years old – 2-3 times a day, 50 drops; children 2-6 years old – 3 times a day, 25 drops; children under 2 years old – 2 times a day, 25 drops.

Inhalation Lazolvan is usually prescribed:

  • Adults and children over 6 years old – 1-2 inhalations of 2-3 ml of solution per day;
  • Children under 6 years old – 1-2 inhalations of 2 ml of solution per day.

For inhalation, you can use any modern equipment designed for this (except for steam inhalers). To ensure optimal hydration during inhalation, Lazolvan should be mixed with a 0.9% sodium chloride solution in a 1:1 ratio. Since during inhalation therapy a deep breath can lead to the development of a cough, inhalations must be carried out while maintaining a normal breathing rhythm. Before the procedure, it is recommended to warm the Lazolvan inhalation solution to body temperature. Patients with bronchial asthma are recommended to carry out inhalation after taking bronchodilator drugs, which will help avoid nonspecific irritation of the respiratory tract and their spasm.

If symptoms of the disease persist for 4-5 days from the start of taking Lazolvan, it is recommended to consult a doctor.

Side effects

As a rule, Lazolvan is well tolerated.

The following side effects may develop during therapy:

  • Gastrointestinal tract: often - nausea, decreased sensitivity in the esophagus or mouth; uncommon – diarrhea, dyspepsia, heartburn, vomiting, pain in the upper abdomen, dry mucous membrane of the throat and mouth;
  • Nervous system: often – disturbance of taste sensations;
  • Immune system, skin and subcutaneous tissues: rarely - urticaria, rash, angioedema, anaphylactic reactions (including anaphylactic shock), itching and other allergic reactions.

Overdose

Specific symptoms of Lazolvan overdose in humans have not been described.

There is evidence of a medical error and/or accidental overdose, as a result of which symptoms of side effects known for this drug were recorded: dyspepsia, nausea, vomiting, diarrhea, abdominal pain. In some cases, there is a need for symptomatic therapy.

Treatment: you should artificially induce vomiting, rinse the stomach for 1-2 hours after taking the drug. Symptomatic therapy is also indicated.

special instructions

Lazolvan should not be combined with antitussive drugs that impede the removal of sputum.

In patients with severe skin lesions (toxic epidermal necrolysis or Stevens-Johnson syndrome), the early phase may include fever, rhinitis, body pain, sore throat and cough. During symptomatic therapy, it is possible to erroneously prescribe mucolytic drugs such as Lazolvan. There are isolated reports of the detection of toxic epidermal necrolysis and Stevens-Johnson syndrome, which coincided with its administration, but there is no cause-and-effect relationship with the use of Lazolvan.

If the above syndromes develop, you should stop using the drug and immediately seek help from a doctor.

In case of functional disorders of the kidneys, Lazolvan can be used only as prescribed by a doctor.

1 tablet contains 162.5 mg of lactose, in the maximum daily dose (4 tablets) – 650 mg of lactose.

The sorbitol contained in the syrup may have a slight laxative effect. The maximum recommended daily dose of syrup contains 5 g (in 20 ml of syrup 30 mg/5 ml) or 10.5 g (in 30 ml of syrup 15 mg/5 ml) of sorbitol.

The solution for oral administration and inhalation contains the preservative benzalkonium chloride, which during inhalation can cause bronchospasm in patients with increased respiratory tract reactivity. The solution is not recommended to be mixed with alkaline solutions and cromoglycic acid. An increase in the pH value of the solution above 6.3 may lead to precipitation of the active substance or the appearance of opalescence.

Patients who follow a low-sodium diet should take into account that the recommended daily dose (for adults and children over 12 years of age) of Lazolvan in the form of a solution for oral administration and inhalation contains 42.8 mg of sodium.

Use during pregnancy and lactation

Ambroxol penetrates the placental barrier. Preclinical studies did not reveal any direct or indirect adverse effects of the drug on the course of pregnancy, embryonic/fetal, postnatal development and labor.

Extensive clinical experience with the use of the drug from the 28th week of pregnancy has shown no evidence of a negative effect of the drug on the fetus, however, when using Lazolvan during pregnancy, the usual precautions should be followed. The drug is not recommended to be taken in the first trimester of pregnancy. Use in the second or third trimesters is allowed only in cases where the possible risk to the fetus is lower than the potential benefit to the mother.

Ambroxol is excreted in breast milk. There is no data on the development of undesirable effects in children who were breastfed, however, it is not recommended to use Lazolvan during lactation.

Preclinical studies of ambroxol did not reveal any negative effects on fertility.

Use in childhood

When treating children under 12 months of age, Lazolvan is used only in the form of a solution. In such cases, it is necessary to ensure constant medical supervision.

According to the instructions, Lazolvan in the form of tablets is prohibited for use in the treatment of children under the age of 18 years, in the form of lozenges - up to 6 years.

For impaired renal function

In case of renal failure, the drug should be used with caution.

For liver dysfunction

In case of liver failure, the drug should be used with caution.

Drug interactions

There are no data on undesirable clinically significant interactions of Lazolvan with other drugs.

Lazolvan increases the penetration of drugs such as cefuroxime, amoxicillin and erythromycin into the bronchial secretions.

Analogs

Analogs of Lazolvan are: Ambroxol, Ambroxol Vramed, Ambrobene, Medox, Ambrohexal, Bronchorus, Halixol, Flavamed, Lazolvan Uno.

Terms and conditions of storage

Store in a place protected from light, out of reach of children.

  • Lozenges – 3 years at temperatures up to 30 °C;
  • Tablets – 5 years at temperatures up to 30 °C;
  • Syrup – 3 years at temperatures up to 25 °C;
  • Solution for oral administration and inhalation – 5 years at temperatures up to 25 °C.

Conditions for dispensing from pharmacies

Available without a prescription.

Reviews about Lazolvan

Reviews about Lazolvan are mostly positive. Users note that within a few days after taking the drug, there is an improvement in bronchitis and other diseases. According to reviews from parents, Lazolvan in the form of an inhalation solution and syrup has proven itself well in the treatment of children.

Also, some users report the development of side effects (diarrhea, allergic skin reactions).

Price for Lazolvan in pharmacies

The approximate price for Lazolvan is:

  • lozenges (20 pcs per pack) – 211 rubles;
  • tablets: 50 pcs. – 290 rub., 20 pcs. – 170 rub.;
  • syrup in 100 ml bottles: 15 mg/5 ml – 215 rubles, 30 mg/5 ml – 280 rubles;
  • solution for oral administration and inhalation 7.5 mg/ml in 100 ml bottles – 380 rub.

Lazolvan tablets 30 mg 20 pcs.

Lazolvan tab. 30mg n20

Lazolvan 15 mg No. 20 lozenges

Lazolvan 30 mg No. 20 tablets

Lazolvan tablets 30 mg n20

Lazolvan Max capsules 75 mg 10 pcs.

Lazolvan syrup 15 mg/5 ml 100 ml

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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