Lazolvan what kind of medicine is this

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Lazolvan - instructions and price

  • ATX code: R05CB06
  • Release form: tablets, syrup, solution, spray, lozenges

Introduction to instructions for use

1. Pharmacological action

2. indications for use

3. Method of application

Recommended dosage of Lazolvan in the form of syrup for internal use (active substance content - 30 mg per 5 ml):

Table of contents:

  • Patients age 6-12 years: half a teaspoon of the drug up to three times a day;

Recommended dosage of Lazolvan in the form of an oral solution:

  • up to two years of life: 25 drops of the drug twice a day;

In all cases, Lazolvan should be diluted in any liquid and taken with meals.

  • Patients under 6 years of age: 2 ml of the drug for inhalation up to two times a day;

In all cases, the use of Lazolvan is possible using any modern inhalation devices, except the evaporating type.

30 mg of the drug for each kg of body weight, divided into four injections.

4. Side effects

  • Disorders of the digestive system (heartburn, nausea, pain in the stomach, vomiting);

5. Contraindications

  • Use of Lazolvan in the first trimester of pregnancy;

6. During pregnancy and lactation

7. Interaction with other drugs

8. Overdose

9. Release form

Tablets, 30 mg - 20 or 50 pcs.

Syrup for internal use, 15 mg/5 ml - vial. 100 ml or 200 ml; 30 mg/5 ml – vial. 100 ml or 200 ml.

Solution for internal use, 7.5 mg/1 ml - vial. 100 ml.

10. Storage conditions

  • Recommended storage temperature (Lazolvan in solution form) is no more than 25 degrees;

Recommended shelf life for various forms of the drug:

11. Composition

1 lozenge:

  • ambroxol hydrochloride - 15 mg;

1 tablet:

  • ambroxol hydrochloride - 30 mg;

5 ml syrup:

  • ambroxol hydrochloride - 15 or 30 mg;

1 ml solution:

  • ambroxol hydrochloride - 7.5 mg;

12. Conditions for dispensing from pharmacies

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REVIEWS ABOUT THE DRUG Lazolvan

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Active ingredients

Pharmacological action

Disease class

  • Pneumonia without specifying the pathogen

Pharmacological group

  • Secretolytics and stimulants of motor function of the respiratory tract Secretolytics and stimulants of motor function of the respiratory tract in combinations

IMPORTANT. The information on the site is provided for informational purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

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Lazolvan

Instructions for use:

Prices in online pharmacies:

Lazolvan is a mucolytic and expectorant drug.

Release form and composition

  • Solution for oral administration and inhalation: transparent, colorless or with a slight brownish tint (100 ml in dark glass bottles equipped with a dropper, 1 bottle in a cardboard box complete with a measuring cup);
  • Syrup: slightly viscous, colorless or almost colorless, transparent or almost transparent, with the smell of wild berries or strawberries (100 or 200 ml in dark glass bottles, 1 bottle in a cardboard box complete with a measuring cap);
  • Tablets: flat on both sides, round, with beveled edges, white or with a yellowish tint, on one side - the company symbol, on the other - a separating line and engraving “67C” on both sides of it (10 pieces in blisters, in a cardboard box 2 or 5 blisters);
  • Lozenges: round, light brown, with the smell of peppermint (10 pieces in blisters, 1, 2 or 4 blisters in a cardboard pack).

The active ingredient of the drug is ambroxol hydrochloride:

  • 1 ml of solution – 7.5 mg;
  • 5 ml of syrup – 15 or 30 mg;
  • 1 tablet – 30 mg;
  • 1 lozenge – 15 mg.
  • Solution: sodium hydrogen phosphate dihydrate, benzalkonium chloride, citric acid monohydrate, sodium chloride, purified water;
  • Syrup: purified water, hyaetellose (hydroxyethylcellulose), benzoic acid, liquid sorbitol (non-crystallizing), acesulfame potassium, glycerol 85%, vanilla flavor, wild berry flavor PHL (in syrup 15 mg/5 ml) or strawberry-cream flavor PHL (in syrup 30 mg/5 ml);
  • Tablets: dried corn starch, lactose monohydrate, colloidal silicon dioxide, magnesium stearate;
  • Lozenges: acacia gum, sorbitol, liquid paraffin (purified mixture of liquid saturated hydrocarbons), carion 83 (mannitol, sorbitol, hydrolyzed hydrogenated starch), sodium saccharinate, purified water, oil of peppermint leaves and eucalyptus leaves.

Indications for use

Lazolvan is used to treat the following acute and chronic diseases of the respiratory tract, which are accompanied by impaired mucociliary clearance and the production of viscous sputum:

  • Bronchiectasis;
  • Acute and chronic bronchitis;
  • Chronic obstructive pulmonary disease;
  • Pneumonia;
  • Bronchial asthma with difficulty in sputum discharge.

Contraindications

For all dosage forms:

  • First trimester of pregnancy;
  • Breastfeeding period;
  • Hypersensitivity to ambroxol or auxiliary components.

Additional contraindications depending on the dosage form:

  • Syrup: children under 6 years of age (for syrup at a dose of 30 mg/5 ml), hereditary fructose intolerance;
  • Tablets: age under 18 years, lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
  • Lozenges: children under 6 years of age, hereditary fructose intolerance.

Lazolvan is used with caution in the second and third trimesters of pregnancy, as well as in case of renal and/or liver failure.

Directions for use and dosage

Lazolvan solution is intended for oral administration and inhalation.

You can take it orally, regardless of food intake; if necessary, dilute it in water, juice, tea or milk.

  • Children under 2 years old – 1 ml 2 times a day;
  • Children 2-6 years old – 1 ml 3 times a day;
  • Children 6-12 years old – 2 ml 2-3 times a day;
  • Children over 12 years of age and adults – 4 ml 3 times a day.

1 ml of solution = 25 drops.

For inhalation, Lazolvan can be used using any modern inhalation equipment, with the exception of steam inhalers. To achieve optimal hydration, the solution is mixed with 0.9% sodium chloride solution in a 1:1 ratio. Inhalations should be carried out in normal breathing mode, since deep inhalation can cause coughing. Before the procedure, it is recommended to warm the drug to body temperature.

Patients with bronchial asthma should inhale Lazolvan after taking a bronchodilator, otherwise nonspecific irritation of the respiratory tract and their spasm may occur.

  • Children under 6 years of age – 2 ml of solution per inhalation, 1-2 inhalations per day;
  • Children over 6 years of age and adults – 2-3 ml of solution per inhalation, 1-2 inhalations per day.

In the form of syrup, Lazolvan is taken orally, regardless of food intake.

Recommended doses for 15 mg/5 ml syrup:

  • Children under 2 years old – 2.5 ml 2 times a day;
  • Children 2-6 years old – 2.5 ml 3 times a day;
  • Children 6-12 years old – 5 ml 2-3 times a day;
  • Children over 12 years of age and adults – 10 ml 3 times a day.

Recommended doses for 30 mg/5 ml syrup:

  • Children 6-12 years old – 2.5 ml 2-3 times a day;
  • Children over 12 years of age and adults – 5 ml 3 times a day.
Lazolvan tablets should be taken orally with liquid, regardless of meals. The drug is prescribed 1 tablet 3 times a day. To enhance the therapeutic effect, you can take 2 tablets 2 times a day.

Lazolvan lozenges should be slowly dissolved in the mouth, regardless of food intake, children aged 6-12 years - 1 piece. 2-3 times a day, children over 12 years old and adults – 2 pcs. 3 times a day.

If symptoms of the disease persist after 4-5 days of treatment, you should consult a doctor.

Side effects

  • Digestive system: often (1-10%) – decreased sensitivity in the oral cavity or pharynx, nausea; uncommon (0.1-1%) – dry mouth, abdominal pain, diarrhea, vomiting, dyspepsia; rarely (0.01-0.1%) – dry throat;
  • Nervous system: often – disturbance of taste sensations;
  • Immune system, skin and subcutaneous tissues: rarely - rash, urticaria, itching, angioedema, hypersensitivity, anaphylactic reactions (including anaphylactic shock).

special instructions

The solution contains benzalkonium chloride as a preservative; when inhaled, it can cause bronchospasm in sensitive patients with increased respiratory tract reactivity.

Lazolvan should not be mixed with alkaline solutions and cromoglycic acid, since increasing the pH value of the solution above 6.3 can lead to precipitation of ambroxol or the appearance of opalescence.

Patients on a low-sodium diet should note that the oral and inhalation solution contains 42.8 mg sodium at the recommended daily dose for children over 12 years of age and adults (12 ml).

One Lazolvan tablet contains 162.5 mg of lactose, the maximum daily dose (4 tablets) is 650 mg.

Syrup Lazolvan 30 mg/5 ml in terms of the maximum daily dose (20 ml) contains 5 g of sorbitol, Lazolvan 15 mg/5 ml in the maximum daily dose (30 ml) - 10.5 g. Due to the sorbitol content, the syrup may have mild laxative effect.

Like any expectorant, Lazolvan should not be used simultaneously with antitussives that make it difficult to remove sputum.

Patients with severe skin lesions (eg, toxic epidermal necrolysis and Stevens-Johnson syndrome) may initially develop fever, rhinitis, body pain, sore throat, and cough. During symptomatic therapy, ambroxol hydrochloride may be prescribed erroneously. There are isolated reports of the detection of such severe lesions that coincided with the use of Lazolvan, but there is no cause-and-effect relationship with the drug. Therefore, if the described symptoms develop, you should stop treatment with ambroxol and immediately consult a doctor.

Studies have not been conducted on the effect of Lazolvan on a person’s ability to perform activities related to reaction speed and increased concentration. However, no cases of negative effects were identified.

Drug interactions

There have been no reports of clinically significant, undesirable interactions between ambroxol hydrochloride and other drugs.

Ambroxol enhances the penetration of erythromycin, amoxicillin and cefuroxime into the bronchial secretions.

Terms and conditions of storage

Store in a place protected from light and out of reach of children at temperatures: solution and syrup - up to 25 ºС, tablets and lozenges - up to 30 ºС.

The shelf life of the solution and tablets is 5 years, syrup and lozenges are 3 years.

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Lazolvan tablets 30 mg 20 pcs.

Lazolvan tab. 30mg n20

Lazolvan 15 mg No. 20 lozenges

Lazolvan 30 mg No. 20 tablets

Lazolvan tablets 30 mg n20

Lazolvan Max capsules 75 mg 10 pcs.

Lazolvan syrup 15 mg/5 ml 100 ml

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What does Lazolvan help with? Instructions for use.

The drug belongs to the following groups:

Lazolvan is an effective expectorant and mucolytic agent, the main purpose of which is to treat diseases of the lungs and bronchi. It helps to enhance the action of enzymes that destroy mucus and reduce the viscosity of bronchial sputum, regulating the ratio of its components.

The positive effect of taking it is due to the active substance included in its composition - ambroxol hydrochloride. It activates the process of mucus removal by stimulating the activity of the epithelial cilia of the bronchi. The therapeutic effect of this drug is observed 30 minutes after administration and lasts for 6 to 12 hours.

Compound

The main active ingredient of this drug is ambroxol or ambroxol hydrochloride, and additional components are corn starch, silicon, lactose, magnesium stearate, water and various flavorings.

What does Lazolvan help with?

Doctors recommend taking this medication for various respiratory diseases accompanied by the formation of viscous sputum, including:

  • chronic or acute bronchitis;
  • bronchial asthma;
  • respiratory failure in newborns;
  • pneumonia;
  • bronchiectasis.

Doctors advise not to use this medication in cases such as:

  1. first trimester of pregnancy;
  2. liver or kidney failure;
  3. sensitivity to the components of the drug;
  4. lactation period.

To avoid possible allergic reactions due to taking this drug, read the list of contraindications in advance and, if necessary, consult your doctor.

Dosage regimen

The dosage of this medicine is determined by your doctor. It depends on the individual characteristics of your body, the pathology to which you are susceptible, as well as on the form of release of this medication.

  • The medicine in tablet form should be taken after meals with plenty of liquid. Adults need to drink 30 mg 3 times a day. To enhance the therapeutic effect, it is recommended to take 60 mg of Lazolvan 2 times a day.
  • Lazolvan in the form of syrup should be given to children whose age has exceeded the age mark of 12 years, and to adults, 10 ml 3 times a day, and to children from 6 to 12 years old – 5 ml. Children whose age ranges from 2 to 6 years are recommended to take 2.5 ml 3 times a day, and children under 2 years old - 2.5 ml 2 times a day.

The average duration of treatment is 4 – 5 days. After this period, Lazolvan can be taken only under medical supervision.

Side effect

This drug has the following side effects, which may occur with excessive use of Lazolvan, as well as in cases of individual intolerance to this drug:

  • cessation of normal functioning of internal organs;
  • discomfort in the gastrointestinal tract: heartburn, nausea, pain, etc.;
  • allergic manifestations of various types.

Drug interactions and special instructions for use

Doctors do not recommend combining this medication with other drugs that make it difficult to remove mucus. It is also undesirable to take Lazolvan with amoxicillin or erythromycin, since their increased penetration into bronchial secretions is observed.

If you treat patients with skin diseases, Stevens-Johnson syndrome, with this medication, they may experience the following adverse reactions:

  • severe body pain;
  • cough;
  • inflammatory processes in the throat;
  • elevated body temperature.

If the above-mentioned symptoms develop and the patient’s well-being worsens while taking this drug, it is recommended to stop treatment and immediately inform your doctor about what is happening.

Take care of yourself and be healthy!

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Lazolvan: reviews

Before using medications, consult your doctor!

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Lazolvan - instructions for use, analogs, reviews and release forms (tablets 30 mg, syrup, solution for inhalation, lozenges 15 mg) of a drug for the treatment of cough and bronchitis in adults, children and pregnancy

In this article you can read the instructions for use of the drug Lazolvan. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Lazolvan in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Lazolvan in the presence of existing structural analogues. Use for the treatment of bronchitis, pneumonia and cough in adults, children, as well as during pregnancy and lactation.

Lazolvan is a mucolytic drug.

Studies have shown that ambroxol (the active ingredient of Lazolvan) increases secretion in the respiratory tract. Enhances the production of pulmonary surfactant and stimulates ciliary activity. These effects lead to increased mucus flow and transport (mucociliary clearance). Increasing mucociliary clearance improves sputum discharge and relieves cough.

Lazolvan is characterized by rapid and almost complete absorption with a linear dose dependence in the therapeutic concentration range. The transition of ambroxol from the blood to tissues when administered orally occurs quickly. The highest concentrations of the active component of the drug are observed in the lungs. Approximately 30% of the dose taken undergoes a first-pass effect through the liver. The remainder of ambroxol is metabolized in the liver, mainly by conjugation.

Acute and chronic diseases of the respiratory tract, accompanied by the release of viscous sputum:

  • acute and chronic bronchitis;
  • pneumonia;
  • chronic obstructive pulmonary disease;
  • bronchial asthma with difficulty in sputum discharge;
  • bronchiectasis.

Syrup (children's form of the drug).

Solution for oral administration and inhalation.

Instructions for use and dosage

The drug in tablet form is prescribed to adults 30 mg 3 times a day.

If necessary, to enhance the therapeutic effect, you can prescribe 60 mg 2 times a day. The tablets are taken after meals with liquid.

The drug in the form of a syrup of 15 mg/5 ml is prescribed to adults and children over 12 years of age, 10 ml (2 teaspoons) 3 times a day; children aged 6 to 12 years - 5 ml (1 teaspoon) 2-3 times a day; children aged 2 to 6 years are prescribed 2.5 ml (1/2 teaspoon) 3 times a day; children under 2 years old - 2.5 ml (1/2 teaspoon) 2 times a day.

The drug in the form of a syrup 30 mg/5 ml is prescribed to adults and children over 12 years of age 5 ml (1 teaspoon) 3 times a day; children aged 6 to 12 years - 2.5 ml (1/2 teaspoon) 2-3 times a day.

Taking the drug for more than 4-5 days is possible only under the supervision of a doctor.

Lazolvan in the form of syrup should be taken during meals with liquid.

Lazolvan in the form of an inhalation solution can be used with any modern inhalation device, except for evaporating inhalers. The drug is mixed with saline in a 1:1 ratio to achieve optimal air humidification in the respirator.

During inhalation, in order to avoid a cough reflex caused by a deep breath, the patient should breathe calmly. It is recommended to warm the inhaled solution to body temperature. Patients with bronchial asthma are recommended to take inhalations after taking bronchodilators.

  • heartburn;
  • dyspepsia;
  • nausea, vomiting;
  • diarrhea;
  • skin rash;
  • hives;
  • angioedema;
  • anaphylactic reactions (including anaphylactic shock).
  • 1st trimester of pregnancy;
  • hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

Lazolvan penetrates the placental barrier.

Experimental studies on animals did not reveal direct or indirect adverse effects on pregnancy, embryonic, prenatal and postnatal development and childbirth.

Clinical studies during 28 weeks of pregnancy found no evidence of a negative effect of the drug on the fetus.

However, the usual precautions should be taken when using the drug during pregnancy. It is especially not recommended to take Lazolvan in the 1st trimester of pregnancy.

Ambroxol can be excreted in human milk. Therefore, it is not recommended to prescribe Lazolvan to nursing mothers. However, an adverse effect in newborns is unlikely.

Should not be used in combination with antitussives that impede the removal of sputum.

Lazolvan syrup (15 mg/5 ml) contains 10.5 g of sorbitol based on the maximum recommended daily dose (30 ml). Patients with rare hereditary fructose intolerance should not take this drug. It may also have a mild laxative effect.

Lazolvan syrup (30 mg/5 ml) contains 5 g of sorbitol based on the maximum recommended daily dose (20 ml). Patients with rare hereditary fructose intolerance should not take this drug.

Lazolvan tablets (30 mg) contain 684 mg of lactose based on the maximum recommended daily dose (120 mg). Patients with rare hereditary galactose intolerance, Lapp lactase deficiency or impaired glucose/galactose absorption should not take this drug.

Very rare cases of severe skin lesions have been reported, such as Stevens-Johnson syndrome and Lyell's syndrome; however, the relationship with the drug has not been proven. If the above syndromes develop, it is recommended to stop treatment and immediately seek medical help.

Simultaneous use with antitussive drugs leads to difficulty in sputum discharge while reducing cough.

Ambroxol increases the penetration of amoxicillin, cefuroxime, erythromycin, and doxycycline into the bronchial secretions.

Lazolvan is compatible with drugs that inhibit labor.

Analogues of the drug Lazolvan

Structural analogues of the active substance:

Source: http://instrukciya-otzyvy.ru/110-lazolvan-po-primeneniyu-analogi-tabletki-sirop-rastvor-dlya-ingalyaciy-pastilki-kashel-bronhit.html

Lazolvan

Lazolvan: instructions for use and reviews

Latin name: Lasolvan

ATX code: R05CB06

Active ingredient: ambroxol (ambroxol)

Manufacturer: Instituto De Angeli (Italy), Boehringer Ingelheim Ellas (Greece), Bolder Arzneimittel GmbH & Co. KG (Germany), Delpharm Reims (France)

Update of description and photo: 08/29/2017

Prices in pharmacies: from 156 rubles.

Lazolvan is an expectorant and mucolytic drug.

Release form and composition

Lazolvan is produced in the following dosage forms:

  • Lozenges: round, light brown, with the smell of peppermint (in blisters of 10 pcs., 1, 2 or 4 blisters in a cardboard box);
  • Tablets: round, slightly yellowish or white, flat on both sides, with beveled edges, on one side there is a separating line and the inscription “67C” embossed on both sides of it, on the other - the company symbol (in blisters of 10 pcs., 2 or 5 blisters in a cardboard box);
  • Syrup: almost colorless or colorless, almost transparent or transparent, with the smell of wild berries (15 mg/5 ml each) or strawberry smell (30 mg/5 ml each), slightly viscous (in dark glass bottles of 100, 200 or 250 ml per complete with or without a measuring cup, 1 bottle in a cardboard box);
  • Solution for oral administration and inhalation: transparent, slightly brownish or colorless (in dark glass bottles of 100 ml, complete with a dosing cup or beaker, 1 bottle in a cardboard box).

The composition of 1 lozenge Lazolvan includes:

  • Active substance: ambroxol – 15 mg (in the form of hydrochloride);
  • Auxiliary components: acacia gum – 850 mg, sorbitol – 307.4 mg, carion 83 (mannitol, sorbitol, hydrogenated hydrolyzed starch) – 614.8 mg, peppermint leaf oil – 10 mg, eucalyptus leaf oil – 2 mg, saccharin sodium – 1.8 mg, liquid paraffin (purified mixture of liquid saturated hydrocarbons) – 2.4 mg, purified water – 196.6 mg.

The composition of 1 tablet Lazolvan includes:

  • Active substance: ambroxol – 30 mg (in the form of hydrochloride);
  • Auxiliary components: lactose monohydrate – 171 mg, dried corn starch – 36 mg, colloidal silicon dioxide – 1.8 mg, magnesium stearate – 1.2 mg.

The composition of 5 ml of Lazolvan syrup includes:

  • Active substance: ambroxol – 15 or 30 mg (in the form of hydrochloride);
  • Auxiliary components (15/30 mg per 5 ml, respectively): benzoic acid - 8.5/8.5 mg, hydroxyethylcellulose (hyetellose) - 10/10 mg, acesulfame potassium - 5/5 mg, liquid sorbitol (non-crystallizing) - 1750/1750 mg, glycerol 85% – 750/750 mg, vanilla flavor – 3/3 mg, purified water – 3047.5/3031.5 mg, wild berry flavor PHL – 11 mg (for syrup 15 mg/5 ml) or strawberry-cream flavor PHL – 12 mg (for syrup 30 mg/5 ml).

The composition of 1 ml of solution for oral administration and inhalation of Lazolvan includes:

  • Active substance: ambroxol – 7.5 mg (in the form of hydrochloride);
  • Auxiliary components: citric acid monohydrate - 2 mg, sodium hydrogen phosphate dihydrate - 4.35 mg, sodium chloride - 6.22 mg, benzalkonium chloride - 0.225 mg, purified water - 989.705 mg.

Pharmacological properties

Pharmacodynamics

Research data show that ambroxol, which is the active component of Lazolvan, causes an increase in secretion in the respiratory tract. As a result of exposure to the drug, the production of pulmonary surfactant and ciliary activity are enhanced. These effects stimulate the flow and transport of mucus (mucociliary clearance), resulting in intense mucus discharge and cough relief. In the treatment of chronic obstructive pulmonary disease during long-term therapy with Lazolvan (for 2 months or more), the number of exacerbations decreased significantly. A significant decrease in the duration of exacerbations and the number of days of antibiotic therapy was recorded.

Pharmacokinetics

All dosage forms of immediate release ambroxol are characterized by rapid and almost complete absorption (a linear dependence of absorption on dose is observed). When taken orally, the maximum concentration of ambroxol in plasma is achieved after 60–150 minutes. Distribution volume – 552 l. The binding of ambroxol to plasma proteins in the therapeutic concentration range is approximately 90%.

When administered orally, the transition of the active substance from the blood to the tissues occurs quickly. The highest concentrations of ambroxol are observed in the lungs. About 30% of an oral dose undergoes a first pass process through the liver. Studies on human liver microsomes have proven that the predominant isoform is the CYP3A4 isoenzyme. It is responsible for the metabolism of the active substance to dibromanthranilic acid. The remaining amount is metabolized in the liver, mostly by glucuronidation and through partial degradation (approximately 10%) to dibromoantranilic acid and additional metabolites in small quantities. The terminal half-life is 10 hours. Total clearance is up to 660 ml/min, with about 8% of the total clearance being renal clearance. In studies using the radioactive tracer method, it was calculated that as a result of taking a single dose of ambroxol over the next 5 days, approximately 83% of the dose taken is excreted in the urine.

A clinically significant effect of gender and age on the pharmacokinetics of ambroxol has not been recorded, so there is no reason to select the dosage based on these characteristics.

Indications for use

Lazolvan is prescribed for the treatment of the following acute and chronic diseases of the respiratory tract, which occur with the release of viscous sputum:

  • Bronchiectasis;
  • Pneumonia;
  • Bronchitis in acute and chronic course;
  • Bronchial asthma, occurring with difficulty in sputum discharge;
  • Chronic obstructive pulmonary disease.

Contraindications

  • First trimester of pregnancy and lactation period;
  • Hypersensitivity to the components of the drug.

Lazolvan should be used with caution in pregnant women in the second and third trimesters, as well as in those with renal and/or liver failure.

Children, depending on the dosage form of Lazolvan, can take:

  • Lozenges and syrup 30 mg/5 ml: from 6 years;
  • Tablets: from 18 years of age.

The lozenges, based on the maximum recommended daily dose (90 mg), contain 3200 mg of sorbitol, so patients with rare hereditary fructose intolerance should not take Lazolvan in this dosage form.

Lazolvan in tablet form is contraindicated for patients with lactase deficiency, lactose intolerance and glucose-galactose malabsorption.

Lazolvan syrup should not be taken by patients with hereditary fructose intolerance.

Instructions for use of Lazolvan: method and dosage

Lazolvan is used orally or inhaled.

The drug can be taken orally regardless of the time of meal.

Lozenges should be slowly dissolved in the mouth, tablets should be taken with liquid, the solution can be diluted in juice, tea, milk or water.

As a rule, Lazolvan is prescribed orally:

  • Lozenges: adults and children over 12 years old – 3 times a day, 2 lozenges; children 6-12 years old – 2-3 times a day, 1 lozenge;
  • Tablets: 3 times a day, 1 tablet; to enhance the therapeutic effect, it is possible to increase the daily dose (2 times a day, 2 tablets);
  • Syrup 15 mg/5 ml: adults and children over 12 years old – 3 times a day, 10 ml; children 6-12 years old – 2-3 times a day, 5 ml; children 2-6 years old – 3 times a day, 2.5 ml; children under 2 years old – 2.5 ml 2 times a day;
  • Syrup 30 mg/5 ml: adults and children over 12 years old – 3 times a day, 5 ml; children 6-12 years old – 2-3 times a day, 2.5 ml;
  • Oral solution (1 ml = 25 drops): adults and children over 12 years old – 3 times a day, 100 drops; children 6-12 years old – 2-3 times a day, 50 drops; children 2-6 years old – 3 times a day, 25 drops; children under 2 years old – 2 times a day, 25 drops.

Inhalation Lazolvan is usually prescribed:

  • Adults and children over 6 years old – 1-2 inhalations of 2-3 ml of solution per day;
  • Children under 6 years old – 1-2 inhalations of 2 ml of solution per day.

For inhalation, you can use any modern equipment designed for this (except for steam inhalers). To ensure optimal hydration during inhalation, Lazolvan should be mixed with a 0.9% sodium chloride solution in a 1:1 ratio. Since during inhalation therapy a deep breath can lead to the development of a cough, inhalations must be carried out while maintaining a normal breathing rhythm. Before the procedure, it is recommended to warm the Lazolvan inhalation solution to body temperature. Patients with bronchial asthma are recommended to carry out inhalation after taking bronchodilator drugs, which will help avoid nonspecific irritation of the respiratory tract and their spasm.

If symptoms of the disease persist for 4-5 days from the start of taking Lazolvan, it is recommended to consult a doctor.

Side effects

As a rule, Lazolvan is well tolerated.

The following side effects may develop during therapy:

  • Gastrointestinal tract: often - nausea, decreased sensitivity in the esophagus or mouth; uncommon – diarrhea, dyspepsia, heartburn, vomiting, pain in the upper abdomen, dry mucous membrane of the throat and mouth;
  • Nervous system: often – disturbance of taste sensations;
  • Immune system, skin and subcutaneous tissues: rarely - urticaria, rash, angioedema, anaphylactic reactions (including anaphylactic shock), itching and other allergic reactions.

Overdose

Specific symptoms of Lazolvan overdose in humans have not been described.

There is evidence of a medical error and/or accidental overdose, as a result of which symptoms of side effects known for this drug were recorded: dyspepsia, nausea, vomiting, diarrhea, abdominal pain. In some cases, there is a need for symptomatic therapy.

Treatment: you should artificially induce vomiting, rinse the stomach for 1-2 hours after taking the drug. Symptomatic therapy is also indicated.

special instructions

Lazolvan should not be combined with antitussive drugs that impede the removal of sputum.

In patients with severe skin lesions (toxic epidermal necrolysis or Stevens-Johnson syndrome), the early phase may include fever, rhinitis, body pain, sore throat and cough. During symptomatic therapy, it is possible to erroneously prescribe mucolytic drugs such as Lazolvan. There are isolated reports of the detection of toxic epidermal necrolysis and Stevens-Johnson syndrome, which coincided with its administration, but there is no cause-and-effect relationship with the use of Lazolvan.

If the above syndromes develop, you should stop using the drug and immediately seek help from a doctor.

In case of functional disorders of the kidneys, Lazolvan can be used only as prescribed by a doctor.

1 tablet contains 162.5 mg of lactose, in the maximum daily dose (4 tablets) – 650 mg of lactose.

The sorbitol contained in the syrup may have a slight laxative effect. The maximum recommended daily dose of syrup contains 5 g (in 20 ml of syrup 30 mg/5 ml) or 10.5 g (in 30 ml of syrup 15 mg/5 ml) of sorbitol.

The solution for oral administration and inhalation contains the preservative benzalkonium chloride, which during inhalation can cause bronchospasm in patients with increased respiratory tract reactivity. The solution is not recommended to be mixed with alkaline solutions and cromoglycic acid. An increase in the pH value of the solution above 6.3 may lead to precipitation of the active substance or the appearance of opalescence.

Patients who follow a low-sodium diet should take into account that the recommended daily dose (for adults and children over 12 years of age) of Lazolvan in the form of a solution for oral administration and inhalation contains 42.8 mg of sodium.

Use during pregnancy and lactation

Ambroxol penetrates the placental barrier. Preclinical studies did not reveal any direct or indirect adverse effects of the drug on the course of pregnancy, embryonic/fetal, postnatal development and labor.

Extensive clinical experience with the use of the drug from the 28th week of pregnancy has shown no evidence of a negative effect of the drug on the fetus, however, when using Lazolvan during pregnancy, the usual precautions should be followed. The drug is not recommended to be taken in the first trimester of pregnancy. Use in the second or third trimesters is allowed only in cases where the possible risk to the fetus is lower than the potential benefit to the mother.

Ambroxol is excreted in breast milk. There is no data on the development of undesirable effects in children who were breastfed, however, it is not recommended to use Lazolvan during lactation.

Preclinical studies of ambroxol did not reveal any negative effects on fertility.

Use in childhood

When treating children under 12 months of age, Lazolvan is used only in the form of a solution. In such cases, it is necessary to ensure constant medical supervision.

According to the instructions, Lazolvan in the form of tablets is prohibited for use in the treatment of children under the age of 18 years, in the form of lozenges - up to 6 years.

For impaired renal function

In case of renal failure, the drug should be used with caution.

For liver dysfunction

In case of liver failure, the drug should be used with caution.

Drug interactions

There are no data on undesirable clinically significant interactions of Lazolvan with other drugs.

Lazolvan increases the penetration of drugs such as cefuroxime, amoxicillin and erythromycin into the bronchial secretions.

Analogs

Analogs of Lazolvan are: Ambroxol, Ambroxol Vramed, Ambrobene, Medox, Ambrohexal, Bronchorus, Halixol, Flavamed, Lazolvan Uno.

Terms and conditions of storage

Store in a place protected from light, out of reach of children.

  • Lozenges – 3 years at temperatures up to 30 °C;
  • Tablets – 5 years at temperatures up to 30 °C;
  • Syrup – 3 years at temperatures up to 25 °C;
  • Solution for oral administration and inhalation – 5 years at temperatures up to 25 °C.

Conditions for dispensing from pharmacies

Available without a prescription.

Reviews about Lazolvan

Reviews about Lazolvan are mostly positive. Users note that within a few days after taking the drug, there is an improvement in bronchitis and other diseases. According to reviews from parents, Lazolvan in the form of an inhalation solution and syrup has proven itself well in the treatment of children.

Also, some users report the development of side effects (diarrhea, allergic skin reactions).

Price for Lazolvan in pharmacies

The approximate price for Lazolvan is:

  • lozenges (20 pcs per pack) – 211 rubles;
  • tablets: 50 pcs. – 290 rub., 20 pcs. – 170 rub.;
  • syrup in 100 ml bottles: 15 mg/5 ml – 215 rubles, 30 mg/5 ml – 280 rubles;
  • solution for oral administration and inhalation 7.5 mg/ml in 100 ml bottles – 380 rub.

Lazolvan tablets 30 mg 20 pcs.

Lazolvan tab. 30mg n20

Lazolvan 15 mg No. 20 lozenges

Lazolvan 30 mg No. 20 tablets

Lazolvan tablets 30 mg n20

Lazolvan Max capsules 75 mg 10 pcs.

Lazolvan syrup 15 mg/5 ml 100 ml

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Source: http://www.neboleem.net/lazolvan.php

Lazolvan

I have a cold and am taking it now

tetracycline, rinicold, lazolvan. I would like to know if it is possible for me

Should I continue injecting or interrupt treatment for the duration of the cold? Thank you

Lazolvan, cough does not go away. Please advise more

You need to consult a pulmonologist.

Obviously, you will need an injection (infusion) form of the drug.

The information provided is intended for medical and pharmaceutical professionals, should not be used for treatment and cannot be considered as official. The most accurate information about the drug is contained in the instructions supplied with the packaging by the manufacturer. No information posted on this or any other page of our website can serve as a substitute for personal contact with a specialist.

Please pay attention to the specified dates for entering information; information may become outdated.

Source: http://www.webapteka.ru/drugbase/name279.html

What does Lazolvan help with?

Lazolvan is an effective medication that helps to quickly cope with various inflammatory diseases of the respiratory tract, accompanied by a significant disturbance in the discharge of sputum and mucus.

This drug has pronounced expectorant, secretolytic, as well as mucolytic (antitussive) effects.

Regular use of Lazolvan can significantly reduce the viscosity of sputum in the respiratory tract, while normalizing breathing, as well as reducing possible coughing of varying intensity.

The main active medicinal substance of this drug is Ambroxol, which has good expectorant and antitussive properties.

Main indications for use of Lazolvan:

  • acute or chronic form of bronchitis;
  • bronchiectasis;
  • pneumonia (pneumonia);
  • laryngotracheitis;
  • chronic obstructive pulmonary disease;
  • bronchial asthma, which is accompanied by a significant disturbance in the discharge of sputum and mucus from the respiratory tract.

Attention: before using Lazolvan, it is recommended to consult with a qualified pulmonologist or therapist!

The drug is produced in the form of soluble tablets, as well as syrup for internal use.

How to drink Lazolvan?

The daily dose of Lazolvan for adults is 1 t. 2-3 r. a day after meals, with plenty of water.

The minimum interval between doses is 4-5 hours, while the maximum daily dose should not exceed more than 3-4 tons.

For children, this drug is usually prescribed in syrup, depending on age and the specific inflammatory disease of the respiratory system.

For adults and children over 14 years of age, the daily dose of Lazolvan in syrup is 10 ml. 2-3 r. for a day. The average course of treatment is 7-10 days, depending on the severity of a particular disease.

Recommended doses for children:

  • 1-2 years: 2-2.5 ml. 1-2 r. for a day;
  • 3-5 years: 2.5 ml. no more than 2-3 rubles/day;
  • 6-10 years: 5 ml. 2 rubles/day;
  • 11-14 years: 5-6 ml. 2-3 rubles/day.

If necessary, a second course of treatment with Lazolvan is possible after about 2-3 months only after mandatory consultation with your doctor!

Contraindications to the use of Lazolvan

  • hypersensitivity (increased sensitivity of the body to the main active ingredient of the drug);
  • pregnancy and lactation (breastfeeding);
  • acute renal or liver failure.

Side effects of Lazolvan

As a rule, this drug is well tolerated by patients after long-term use, but sometimes minor adverse reactions may occur in the form of:

  • local allergic reactions on the skin (urticaria, increased skin itching, erythema);
  • nausea or vomiting (occurs extremely rarely, mainly with a significant overdose of the drug);
  • diarrhea;
  • minor pain in the epigastric (epigastric) region of the abdomen;
  • dry mouth.

If any of the above side effects develop, it is recommended to consult your doctor!

In this article, we looked at what Lazolvan helps with, as well as how to take it correctly.

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Remember, self-medication is dangerous to your health! Consult your doctor

Source: http://in4health.ru/ot-chego-pomogaet-lazolvan.html

Lazolvan

Acute and chronic diseases of the respiratory tract, accompanied by the release of viscous sputum:

– acute and chronic bronchitis;

– chronic obstructive pulmonary disease;

– bronchial asthma with difficulty in sputum discharge;

– treatment of respiratory distress syndrome in premature and newborn babies;

Ambroxol hydrochloride, the active ingredient of lazolvan, increases the secretion of mucus in the respiratory tract. Ambroxol hydrochloride increases the synthesis of pulmonary surfactant and stimulates ciliary activity. These effects lead to improved mucus secretion and elimination (mucociliary clearance). Activation of fluid secretion and increased mucociliary clearance facilitate the removal of mucus and reduce cough.

Absorption of ambroxol is rapid and quite complete, with a linear dependence in the therapeutic range. The maximum concentration of the active substance in plasma is achieved after 30 minutes - 3 hours. In plasma, approximately 90% of the product is bound to proteins. The distribution of ambroxol between the blood and tissues occurs quickly, and a high concentration of active substances is observed in the lungs. The plasma half-life is 7-12 hours; accumulation in tissues was not detected. Ambroxol is metabolized mainly in the liver by conjugation. About 90% of the product is excreted by the kidneys.

Orally, should be taken during meals with a small amount of liquid. Adults and children over 12 years of age are prescribed tablets: 30 mg 3 times a day in the first 2-3 days, then 30 mg 2 times or 15 mg 3 times a day; children 6-12 years old - 15 mg 2-3 times a day.

Hypersensitivity to ambroxol or other components of the product.

Lazolvan is generally well tolerated. Minor gastrointestinal disorders are possible (mainly heartburn, dyspepsia; less commonly, nausea and vomiting). Allergic reactions, such as skin rashes, may occur.

Preclinical studies, as well as extensive clinical experience with the use of the product after the 28th week of pregnancy, have not revealed any harmful effects of the product during pregnancy.

There have been no reports of overdose with the product. In case of overdose symptoms, symptomatic treatment is carried out.

Taking lazolvan together with antibiotics (amoxicillin, cefuroxime, erythromycin, doxycycline) leads to an increase in the concentration of antibiotics in lung tissue.

Solution for intravenous administration, 2 ml in ampoules. 10 ampoules per pack.

Tablets 10 pcs. in a pack.

Syrup in bottles of 100 ml.

Oral solution in 100 ml bottles.

Store at room temperature (not higher than 25°C for solution and not higher than 30°C for other forms of release) out of reach of children. Protect from direct sunlight, heat and frost.

tablets - 5 years;

syrup 15 mg/5 ml - 3 years;

syrup 30 mg/5 ml - 5 years;

International and chemical name: ambroxol: trans-4-[(2-amino-3,5-dibromo-benzyl (amino)) cyclohexanol hydrochloride].

Before using Lazolvan, you should consult your doctor.

The instructions are provided solely for familiarization with Lazolvan.

Group affiliation:

ALPHABETIC INDEX

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This material is for educational purposes only and is not intended for medical advice, diagnosis or treatment.

Source: http://medprep.info/drug/medicament/1099