Clarotadine syrup instructions

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LORATADINE-AKRIKHIN

◊ Tablets are white or almost white, flat-cylindrical, with a bevel.

Excipients: lactose monohydrate mg, microcrystalline cellulose - 75 mg, calcium stearate - 2 mg, sodium carboxymethyl starch - 3 mg.

Table of contents:

7 pcs. — cellular contour packages (1) — cardboard packs.

7 pcs. — cellular contour packages (3) — cardboard packs.

10 pieces. — cellular contour packages (1) — cardboard packs.

10 pieces. — cellular contour packages (3) — cardboard packs.

◊ Syrup in the form of a clear liquid from light yellow to yellow in color, with a faint fruity odor.

Excipients: sucrose - 35 g, propylene glycol - 20 g, benzoic acid - 0.1 g, citric acid - 0.3 g, ethanol (rectified ethyl alcohol) - 1.58 g, tropeolin O dye - 0.001 g, orange flavor - 0.08 g, purified water - up to 100 ml.

100 ml - dark glass bottles (1) complete with a measuring spoon - cardboard packs.

histamine H1 receptor . It has antiallergic, antipruritic, antiexudative effects. Prevents the development and facilitates the course of allergic reactions.

Suppresses the release of histamine and leukotriene C4 from mast cells. Reduces capillary permeability, prevents the development of tissue edema, relieves spasms of smooth muscles.

Does not affect the central nervous system (because it does not penetrate the BBB) and is not addictive.

The antiallergic effect develops after 30 minutes, reaches a maximum after 8-12 hours and lasts 24 hours.

Suction and distribution

They are quickly and completely absorbed from the gastrointestinal tract. The time to reach Cmax in blood plasma after taking the drug is 1.3-2.5 hours; Eating slows down the time to reach Cmax by 1 hour.

Plasma protein binding - 97%. Css of loratadine and metabolite in plasma are achieved on the 5th day of administration. Does not penetrate the BBB.

Metabolism and excretion

Metabolized in the liver to form the active metabolite descarboethoxyloratadine with the participation of CYP3A4 isoenzymes and, to a lesser extent, CYP2D6.

Excreted by the kidneys and bile. T1 /2 loratadinach (average 8.4 hours), active metabolite - 8.8-92 hours (average 28 hours).

Pharmacokinetics in special groups of patients

C max of the drug in blood plasma in elderly people increases by 50%. T1 /2 of loratadine and the active metabolite in elderly patients, respectively, is 6.7-37 hours (on average 18.2 hours) and (17.5 hours).

With alcoholic liver damage, C max and T 1/2 increase in proportion to the severity of the disease.

In patients with chronic renal failure and during hemodialysis, the pharmacokinetics remain virtually unchanged.

— seasonal and year-round rhinitis (including hay fever);

- urticaria (including chronic idiopathic);

- pseudo-allergic reactions caused by the release of histamine;

- allergic reaction to insect bites.

- children weighing less than 30 kg (for tablets);

- children under 2 years of age (for syrup);

- lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome (for tablets);

- hypersensitivity to any of the components of the drug.

with caution in case of liver failure or pregnancy.

The drug is taken orally.

Adults and children weighing more than 30 kg are prescribed 10 mg (1 tablet or 2 scoops of syrup) 1 time/day.

Children aged 2 to 12 years weighing less than 30 kg are prescribed 5 mg (1 scoop of syrup) 1 time/day.

For renal failure, the initial dose is 10 mg every other day.

For liver failure, the initial dose of the drug is 5 mg/day or 10 mg every other day.

Adverse events occurred at approximately the same frequency as with placebo.

In adults: headache, increased fatigue, dry mouth, drowsiness, nausea, gastritis, allergic reactions (rash), anaphylaxis, alopecia, liver dysfunction, tachycardia.

In children: headache, increased nervous excitability, sedation.

Symptoms: drowsiness, tachycardia, headache.

Treatment: gastric lavage, taking activated carbon. Not excreted by hemodialysis.

CYP3A4 inhibitors (including erythromycin, ketoconazole), CYP3A4 and CYP2D6 inhibitors (cimetidine and others), when used together with loratadine, increase the concentration of loratadine in the blood plasma without causing clinical manifestations and without affecting ECG data.

Inducers of microsomal oxidation (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) reduce the effectiveness of loratadine.

Loratadine does not enhance the effect of ethanol on the central nervous system.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

The use of the drug during pregnancy is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

During treatment, breastfeeding should be stopped (excreted in breast milk).

with caution in case of liver failure.

The drug in tablet form should be stored in a dry place, out of reach of children, at a temperature not exceeding 25°C. Shelf life – 5 years.

The drug in syrup form should be stored in a dry place, out of reach of children, at a temperature of 12° to 15°C. Shelf life: 4 years.

To ask a question about the project or contact the editors, use this form.

Source: http://health.mail.ru/drug/klarotadin/

Clarotadine

Instructions for use:

Clarotadine is an H1 blocker of histamine receptors, an antiallergic agent.

Release form and composition

  • Tablets: flat-cylindrical in shape, white or almost white, with a bevel (7 pcs. in blister packs, 1 pack in a cardboard pack; 10 pcs in blister packs, 1 or 3 packs in a cardboard pack);
  • Syrup: transparent, from light yellow to yellow in color, with a faint fruity aroma (100 ml in dark glass bottles, 1 bottle in a cardboard pack complete with a measuring spoon).

Active substance – loratadine:

Excipients of tablets: microcrystalline cellulose, lactose monohydrate, sodium carboxymethyl starch, calcium stearate.

Additional components of the syrup: benzoic acid, propylene glycol, citric acid, sucrose, purified water, ethanol 96%, orange flavor, tropeolin O dye.

Indications for use

  • Urticaria (including chronic idiopathic);
  • Seasonal and/or year-round rhinitis (including hay fever);
  • Itchy dermatoses;
  • Allergic conjunctivitis;
  • Pseudoallergic reactions caused by the release of histamine;
  • Quincke's edema;
  • Allergic reaction to insect bites.

Contraindications

  • Pregnancy;
  • Lactation;
  • Children under 2 years of age;
  • Hypersensitivity to the components of the drug.

Clarotadine should be used with caution when treating patients with hepatic impairment.

Directions for use and dosage

The drug is taken orally.

  • Adults and children over 12 years of age: 10 mg (1 tablet or 2 scoops of syrup) 1 time per day;
  • Children 2-12 years old: with a body weight of less than 30 kg - 5 mg (1/2 tablet or 1 measuring spoon of syrup) once a day, with a body weight of more than 30 kg - 10 mg once a day.

For patients with impaired liver function or renal failure (glomerular filtration rate below 30 ml/minute), Clarotadine is prescribed 10 mg every other day.

Side effects

  • Central and peripheral nervous system: asthenia, anxiety, tremor, dysphonia, blepharospasm, drowsiness, hyperkinesia, depression, paresthesia, agitation (in children), amnesia;
  • Digestive system: dyspepsia, constipation or diarrhea, gastritis, anorexia, flatulence, change in taste, stomatitis, increased appetite;
  • Respiratory system: dry nasal mucosa, cough, sinusitis, bronchospasm;
  • Musculoskeletal system: myalgia, arthralgia, back pain, calf muscle cramps;
  • Urinary system: painful urge to urinate, change in urine color;
  • Reproductive system: vaginitis, menorrhagia, dysmenorrhea, pain in the mammary glands;
  • Metabolism: thirst, increased sweating, weight gain;
  • Cardiovascular system: increased or decreased blood pressure, chest pain, rapid heartbeat;
  • Sense organs: conjunctivitis, blurred vision, pain in the eyes and ears;
  • Dermatological and allergic reactions: photosensitivity, itching, dermatitis, urticaria, chills, fever, angioedema.

special instructions

During treatment, you should refrain from driving vehicles and performing potentially dangerous types of work that require quick reactions and increased attention.

Drug interactions

Inducers of microsomal oxidation (barbiturates, tricyclic antidepressants, rifampicin, zixorin, phenylbutazone, phenytoin, ethanol) reduce the effectiveness of loratadine.

Erythromycin, ketoconazole and cimetidine increase the concentration of loratadine in the blood plasma, but this has no clinical significance and does not affect electrocardiogram data.

Loratadine used in therapeutic doses does not have a potentiating effect on ethanol.

Analogs

Analogues of Clarotadine are: Alerpriv, Vero-Loratadine, Clalergin, Clargotil, Claridol, Clarisens, Claritin, Clarifer, Clarnedin, Lomilan, Lomilan-Solo, Loragexal, Loratadine, Loratadine Stada, Loratadine 10-SL, Loratadine-OBL, Loratadine-Verte, Loratadin-Teva, Loratadin-Hemofarm, Tirlor, Erolin.

Terms and conditions of storage

Store out of the reach of children, protected from moisture, at a temperature: tablets - up to 25 ºС, syrup - ºС.

The shelf life of tablets is 4 years, syrup – 3 years.

Conditions for dispensing from pharmacies

Available without a prescription.

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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When lovers kiss, each of them loses 6.4 calories per minute, but at the same time they exchange almost 300 types of different bacteria.

When we sneeze, our body stops working completely. Even the heart stops.

More than $500 million a year is spent on allergy medications in the United States alone. Do you still believe that a way to finally defeat allergies will be found?

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The human stomach copes well with foreign objects without medical intervention. It is known that gastric juice can even dissolve coins.

There are very interesting medical syndromes, for example, compulsive swallowing of objects. One patient suffering from this mania had 2,500 foreign objects in her stomach.

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Our kidneys are capable of purifying three liters of blood in one minute.

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Source: http://www.neboleem.net/klarotadin.php

Clarotadine ®

Active substance:

Content

Pharmacological group

Nosological classification (ICD-10)

3D images

Composition and release form

in blister packs 7 or 10 pcs.; in a box 1 package (7 pcs.), 1 or 3 packages (10 pieces).

in bottles of 100 ml; 1 bottle in a cardboard pack.

Description of the dosage form

Tablets: white or almost white, flat-cylindrical, chamfered.

Syrup: light yellow to yellow clear liquid with a faint fruity odor.

pharmachologic effect

Pharmacodynamics

H 1 is an antihistamine that does not have a central or anticholinergic effect.

The effect of the drug begins to develop 30 minutes after administration and continues for 24 hours.

Long-term use of the drug does not cause the development of resistance to its action.

Loratadine and its metabolites do not cross the BBB.

Pharmacokinetics

Suction. When taken orally at the recommended therapeutic dose, loratadine is quickly and completely absorbed from the gastrointestinal tract. Determinable concentrations of loratadine appear in the blood plasma within 15 minutes after administration. The time to reach Cmax of loratadine in plasma is 1.3–2.5 hours, and the time to reach Cmax of its active metabolite is 2.5 hours. Simultaneous intake of food and loratadine slows down the achievement of Cmax of loratadine and its active metabolite in plasma by 1 hour , but the Cmax of these substances in plasma remains unchanged and no clinical manifestations of interaction of loratadine with food are observed. In older people, the time to reach Cmax increases to 1.5 hours, and with alcoholic liver damage it increases with increasing severity of the disease. The content of loratadine and its active metabolite in the blood plasma reaches a steady-state level in most patients on the fifth day of administration. Communication with plasma proteins - 97%.

Metabolism. Loratadine is metabolized in the liver to form the active metabolite descarboethoxyloratadine mainly under the influence of the cytochrome P450 isoenzyme CYP3A4 and to a lesser extent under the influence of the cytochrome P450 isoenzyme CYP2D6. In the presence of ketoconazole, which is a CYP3A4 inhibitor, loratadine is converted to descarboethoxyloratadine primarily by CYP2D6.

Excretion. Loratadine is excreted by the kidneys and bile. The mean half-life of loratadine is 8.4 hours (range, 3 to 20 hours), and for the active metabolite, 28 hours (range, 8.8 to 92 hours). In elderly patients, T1 /2 of loratadine increases to 18.2 hours (range from 6.7 to 37 hours), and for descarboethoxyloratadine - to 17.5 hours (range from 11 to 38 hours). With alcoholic liver damage, T1 /2 increases with increasing severity of the disease. In patients with chronic renal failure and during hemodialysis, the pharmacokinetics remain virtually unchanged.

Indications for the drug Clarotadine ®

Seasonal and year-round rhinitis (including hay fever), allergic conjunctivitis, urticaria (including chronic idiopathic), Quincke's edema, pseudoallergic reactions caused by the release of histamine; itchy dermatoses; allergic reaction to insect bites.

Contraindications

Hypersensitivity to any of the components of the drug, pregnancy, lactation.

With caution: liver failure.

Use during pregnancy and breastfeeding

If you are pregnant, you should avoid taking Clarotadine ® . Breastfeeding should be stopped during treatment.

Side effects

From the nervous system: anxiety, agitation (in children), asthenia, drowsiness, hyperkinesia, paresthesia, tremor, amnesia, depression.

From the skin and subcutaneous fat: dermatitis.

From the genitourinary and urinary system: change in urine color, painful urge to urinate, dysmenorrhea, menorrhagia, vaginitis.

Metabolic: weight gain, sweating, thirst.

From the musculoskeletal system: cramps of the calf muscles, arthralgia, myalgia.

From the digestive system: changes in taste, anorexia, constipation or diarrhea, dyspepsia, gastritis, flatulence, increased appetite, stomatitis.

From the respiratory system: cough, bronchospasm, dry nasal mucosa, sinusitis.

From the senses: blurred vision, conjunctivitis, pain in the eyes and ears.

From the cardiovascular system: decreased or increased blood pressure, palpitations.

Allergic reactions: angioedema, urticaria, itching, photosensitivity.

Other: back pain, chest pain, fever, chills, breast pain, blepharospasm, dysphonia.

Interaction

When using loratadine in therapeutic doses, no potentiating effect on alcohol was detected.

The combined use of loratadine with erythromycin, cimetidine and ketoconazole increases the concentration of loratadine in the blood plasma, which has no clinical manifestations and does not affect ECG data.

Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, zixorin, rifampicin, phenylbutazone, tricyclic antidepressants) reduce the effectiveness of the drug.

Directions for use and doses

Inside . Adults and children over 12 years old - 10 mg (1 tablet or 2 measuring spoons of syrup) 1 time per day. The daily dose is 10 mg.

Children from 2 to 12 years old weighing less than 30 kg - 5 mg (1/2 tablet or 1 scoop of syrup) 1 time per day. The daily dose is 5 mg.

Children weighing more than 30 kg - 10 mg (1 tablet or 2 measuring spoons of syrup) 1 time per day. The daily dose is 10 mg.

Overdose

When taking loratadine in doses significantly higher than the recommended therapeutic dose of 10 mg (40–180 mg loratadine), adult patients may experience symptoms such as headache, drowsiness, and tachycardia. When loratadine is used in children weighing less than 30 kg at a dose of more than 10 mg, extrapyramidal symptoms and increased heart rate may be observed.

Treatment: you should consult a doctor, take measures to remove the drug from the gastrointestinal tract and reduce absorption (induction of vomiting, gastric lavage, taking activated charcoal). If necessary, symptomatic therapy is carried out. Loratadine is not excreted from the body during hemodialysis. There are no data on the elimination of loratadine during peritoneal dialysis.

special instructions

For patients suffering from impaired liver function or renal failure (glomerular filtration rate below 30 ml/min), the initial dose of Clarotadine ® should be 10 mg (1 tablet or 2 scoops) every other day.

Not recommended for children under 2 years of age.

During the treatment period, it is necessary to refrain from engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Manufacturer

JSC "Chemical Plant "Akrikhin"", Russia.

Storage conditions for the drug Clarotadine ®

Keep out of the reach of children.

Shelf life of the drug Clarotadine ®

tablets 0.01 g - 3 years.

tablets 10 mg - 5 years.

syrup 5 mg/5 ml - 3 years.

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

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Loratadine-Akrikhin syrup - official instructions for use

Registration number:

Trade name of the drug:

International nonproprietary name:

Dosage form:

Compound

active substance: loratadine in terms of 100% substance - 0.1 g;

excipients: sucrose 35 g, propylene glycol 20 g, benzoic acid 0.1 g, citric acid 0.3 g, ethanol 96% 1.58 g, tropeolin O dye 0.001 g, orange flavor 0.08 g, purified water to 100 ml.

Description

Pharmacotherapeutic group:

antiallergic agent - H1 - histamine receptor blocker

ATX code:

Pharmacological properties

H1 blocker (long-acting). Suppresses the release of histamine and leukotriene C4 from mast cells. Prevents the development and facilitates the course of allergic reactions. It has antiallergic, antipruritic, anti-exudative effects. Reduces capillary permeability, prevents the development of tissue edema, relieves spasms of smooth muscles. The antiallergic effect develops after 30 minutes, reaches a maximum after 8-12 hours and lasts 24 hours. It does not affect the central nervous system (because it does not penetrate the blood-brain barrier) and is not addictive.

Quickly and completely absorbed from the gastrointestinal tract. The time to reach maximum concentration in blood plasma after taking the drug is 1.3-2.5 hours; food intake slows it down by 1 hour. The maximum concentration of the drug in the blood plasma in elderly people increases by 50%, with alcoholic liver damage - with increasing severity of the disease. Bonding with plasma proteins is 97%. Metabolized in the liver to form the active metabolite descarboethoxyloratadine with the participation of cytochrome isoenzymes CYP3A4 and, to a lesser extent, CYP2D6. The equilibrium concentration of loratadine and metabolite in plasma is achieved on the 5th day of administration. Does not penetrate the blood-brain barrier. The half-life of loratadinach (average 8.4), the active metabolite, is 8.8-92 hours (average 28 hours); in elderly patients, respectively - 6.7-37 hours (average 18.2 hours) and (17.5 hours). In alcoholic liver damage, the half-life of the drug increases in proportion to the severity of the disease. Excreted by the kidneys and bile. In patients with chronic renal failure and during hemodialysis, the pharmacokinetics remain virtually unchanged.

Indications for use:

Contraindications:

Carefully

Use during pregnancy and lactation

Directions for use and doses

For liver failure, the initial dose is 5 mg/day (1 scoop of syrup).

Children from 2 to 12 years old with body weight less than 30 kg - 5 mg/day (1 scoop of syrup) in 1 dose.

Side effect

In adults: headache, increased fatigue, dry mouth, drowsiness, nausea, gastritis, allergic reactions (rash), anaphylaxis, alopecia, liver dysfunction. In children: headache, increased nervous excitability, sedation.

Overdose

Treatment: gastric lavage, taking activated carbon. Not excreted by hemodialysis.

Interaction with other drugs

Loratadine does not enhance the effects of alcohol on the central nervous system.

special instructions

Impact on the ability to drive vehicles and complex equipment

Release form:

100 ml in an orange glass bottle.

Each bottle, along with a measuring spoon and instructions for use, comes in a cardboard box.

Storage conditions

Keep out of the reach of children.

Best before date

Conditions for dispensing from pharmacies:

Manufacturer/Organization accepting consumer complaints:

Open Joint Stock Company "Chemical and Pharmaceutical Plant "AKRIKHIN" (JSC "AKRIKHIN"), Russia

142450, Moscow region, Noginsky district, Staraya Kupavna, st. Kirova, 29.

Source: http://medi.ru/instrukciya/loratadin-akrikhin-sirop_10300/

Clarotadine

Description current as of 01/18/2015

  • Latin name: Clarotadine
  • ATX code: R06AX13
  • Active ingredient: Loratadine
  • Manufacturer: AKRIKHIN OJSC, Russia

Compound

The tablets contain the active ingredient loratadine. Additional components: lactose monohydrate, calcium stearate, microcrystalline cellulose, sodium carboxymethyl starch.

The syrup contains the active ingredient loratadine. Additional ingredients: sucrose, propylene glycol, benzoic and citric acid, ethanol 96%, tropeolin dye, orange flavor, purified water.

Release form

Clarotadine is available in the form of tablets and syrup.

The tablets are packaged in 7 or 10 pieces in cellular packaging, 1 or 3 cells per pack.

The syrup is packaged in a 100 ml bottle, complete with a measuring spoon.

pharmachologic effect

The drug has antiallergic, antipruritic and antiexudative effects.

Pharmacodynamics and pharmacokinetics

Clarotadine is a histamine H1 receptor blocker that exhibits long-term antiallergic, antiexudative and antipruritic effects. The development of the antiallergic effect is observed 30 minutes after administration and persists for at least 24 hours. At the same time, the drug does not affect the nervous system, nor does it have anticholinergic or sedative effects.

The active substance is characterized by good absorption from the gastrointestinal tract. Food does not affect the absorption process, but somewhat slows down the formation of the maximum concentration. Typically, the maximum concentration in plasma is reached after 1.3-2.5 hours. The drug does not penetrate the BBB. The half-life of the component occurs within 24 hours.

Excretion occurs in urine unchanged. At the same time, the patient’s age, liver and kidney disorders do not affect physiological parameters.

Indications for use of Clarotadine

The main indications for the use of this drug are the manifestation of various allergy symptoms:

Contraindications for use

The drug is not prescribed for:

Side effects

When taking Clarotadine, all sorts of side effects can develop, affecting various systems and organs, for example: the functions of the nervous, digestive, respiratory, musculoskeletal, urinary, reproductive, cardiovascular and other systems. Disturbances can manifest themselves as: anxiety, agitation, asthenia, drowsiness, tremor, anorexia, constipation, diarrhea, dyspepsia, cough, sinusitis, arthralgia, myalgia and many other symptoms.

Deviations in metabolism, the functioning of sensory organs, and the development of allergic and dermatological reactions are also possible.

Instructions for use of Clarotadine (Method and dosage)

According to the instructions for use of Clarotadine tablets, this dosage form is prescribed to adult patients and children over 12 years of age, one tablet once a day. Children 2-12 years old, whose weight does not exceed 30 kg, are recommended to take half a tablet per day. If your weight is more than 30 kg, you can take one tablet per day.

The instructions for the syrup recommend that adult patients and children over 12 years of age take a daily dose of 2 scoops of the drug. Children 2-12 years old, whose weight does not exceed 30 kg, are prescribed one measuring spoon, and those weighing more than 30 kg - 2 measuring spoons of syrup per day.

If patients have liver dysfunction or kidney failure, the initial dosage of the drug is prescribed with one tablet or two scoops of syrup, taken every other day.

Overdose

In cases of significant overdose, symptoms may develop in the form of: headache, drowsiness, tachycardia. Taking high doses of loratadine by children whose body weight does not exceed 30 kg can cause extrapyramidal disorders and rapid heartbeat.

In this case, procedures are carried out to remove the drug from the gastrointestinal tract and reduce absorption - induce vomiting, rinse the stomach, take activated charcoal. If necessary, concomitant symptomatic therapy is performed. Hemodialysis is not effective.

Interaction

The simultaneous use of loratadine and Erythromycin, Cimetidine, Ketoconazole increases the concentration of the drug in the blood plasma, but this is not clinically significant and does not affect ECG parameters.

Combination with inducers of microsomal oxidation - ethanol, barbiturates, phenytoin, zyxorin, phenylbutazone, Rifampicin and tricyclic antidepressants reduces the effect of loratadine.

Terms of sale

The drug can be bought without a prescription.

Storage conditions

Tablets and syrup are stored in a dark, dry and cool place up to 15 degrees, out of reach of children.

Best before date

The shelf life for the tablets is 4 years.

The syrup retains its properties for 3 years, subject to storage conditions.

Analogs

The main analogues are represented by the following drugs: Claritin, Loridin, Erolin, Loratadine, Lorid, Lomilan, Clalergin, Clarisens, Clarifer, Alerpriv.

Alcohol

It has been established that the drug does not interact with alcohol. However, ethanol can complicate allergic reactions.

Reviews of Clarotadine

Modern pharmacology offers a huge number of various drugs that help eliminate or alleviate the symptoms of allergies. At the same time, reviews of Clarotadine show that it affects different patients differently: it helps some, but for others it is useless.

Therefore, experts recommend not to start taking such drugs on your own. The fact is that from the whole variety of antiallergic drugs, you can choose the most effective drug and eliminate the development of unwanted reactions.

Sometimes patients report that when they start taking this drug, they experience a severe cough, although other allergy symptoms disappear. This case confirms the development of a side effect of the drug. Also, some users report that Clarotadine stops working over time, suggesting that they are simply used to it.

As you know, allergy symptoms can manifest in different ways and have varying degrees of severity. While some people feel mild discomfort, others experience real suffering. Therefore, allergy sufferers should not experiment with independently choosing antihistamines, but should consult a doctor as soon as possible, who will select the appropriate medicine. This approach will significantly alleviate allergy symptoms, and some of them will be completely eliminated.

Clarotadine price, where to buy

The price of Clarotadine tablets in Russian pharmacies varies within rubles, depending on their quantity in the pack.

You can buy Clarotadine in syrup for the cost of rubles.

  • Online pharmacies in Russia Russia

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Source: http://medside.ru/klarotadin

Clarotadine syrup - official instructions for use

Vero-Loratadine, Claritin, Lomilan, Loratadine, Loratin

II generation histamine H1 receptor blocker

5 ml syrup contains 5 mg loratadine

Histamine H1 receptor blocker (long-acting). It has antiallergic, antipruritic and antiexudative effects. The antiallergic effect begins to develop within the first 30 minutes after taking the drug orally and persists for 24 hours. The drug does not affect the central nervous system and does not have an anticholinergic or sedative effect.

After oral administration, it is well absorbed from the gastrointestinal tract. Eating does not affect the absorption of clorotadine, but slows down the time to reach maximum concentration by 1 hour. The maximum concentration in plasma is reached after 1.3-2.5 hours. It does not penetrate the BBB. The half-life is 24 hours. It is excreted unchanged in the urine. The patient's age, functional state of the liver and kidneys do not affect the main parameters of pharmacokinetics.

  • seasonal and year-round allergic rhinitis (including hay fever);
  • allergic conjunctivitis;
  • urticaria (including chronic idiopathic);
  • allergic itchy dermatoses (allergic contact dermatitis, chronic eczema);
  • angioedema;
  • pseudo-allergic reactions caused by the release of histamine;
  • allergic reactions to insect bites

Directions for use and doses

Adults and children over 12 years of age weighing more than 30 kg - 2 teaspoons of syrup 1 time per day.

Children from 2 to 12 years old weighing less than 30 kg - 1 teaspoon of syrup once a day.

Rarely - dry mouth, nausea, vomiting, gastritis, increased fatigue, headache, excitability (in children), skin rash; in some cases - liver dysfunction, alopecia; in isolated cases - anaphylactic reactions.

In case of overdose - headache, drowsiness, tachycardia.

  • hypersensitivity to the drug;
  • severe liver dysfunction;
  • pregnancy;
  • lactation period;
  • children's age (up to 2 years)

special instructions

The safety of Clarotadine during pregnancy has not been established, so its use is only possible if the expected benefit to the mother outweighs the potential risk to the fetus. Loratadine is excreted in breast milk, therefore, when prescribing Clarotadine during lactation, the issue of stopping breastfeeding should be considered.

Use with caution if liver function is impaired; the initial dose is reduced to 5 mg per day due to a possible violation of the clearance of loratadine. Not addictive.

When used simultaneously with ketoconazole, erythromycin, cimetidine, an increase in the concentration of loratadine in plasma is observed, but without any clinical manifestations, including electrocardiographic ones. Clarotadine does not affect the effect of ethanol on the central nervous system.

Source: http://medi.ru/instrukciya/klarotadin-sirop_709/

Loratadine for a child

Many parents experience an allergic reaction in their child. It may develop in response to inhalation of pollen, taking a medication, eating food, using detergent, or for other reasons. Antihistamines are most often used to combat swelling, rashes, coughs, sore throats and other allergy symptoms. One of them is Loratadine. If it is prescribed to a child, then parents should know how it affects the child’s body and how it is taken correctly.

Release form

Loratadine is produced by many pharmacological companies and its name may contain a prefix indicating the manufacturer. For example, Loratadin Teva is produced by the Israeli company Teva, Loradatin-Akrikhin is a product of the Russian chemical and pharmaceutical plant Akrikhin, and Loratadin-Hemofarm is produced in Serbia by the Hemofarm concern. Moreover, all such drugs have the same active substance, the same indications, possible side effects and contraindications.

Loratadine is available in pharmacies:

  • Syrup. It is a light yellow, sweet-tasting, transparent thick solution with a fruity odor. The volume of syrup in one bottle can be 50, 100 or 120 ml. A cup or measuring spoon is included with the bottle to accurately measure this sweet medicine in the dose prescribed by the doctor.
  • Tablets. Usually these are small round white tablets that have a score. Most often they come in packs of 10 pieces, but one box can contain from 7 to 90 tablets.
  • Effervescent tablets. Loratadine-Hemofarm is produced in this form. Such tablets are sold in plastic tubes of 10 pieces, and one box contains 1-2 tubes.

Compound

All forms of the drug contain the same active substance, which is also called loratadine. In 5 ml of syrup it is presented at a dosage of 5 mg, and one tablet contains 10 mg. The content of loratadine in one effervescent tablet is also 10 mg.

In addition to the active ingredient, the composition of the syrup includes citric acid, propylene glycol, water, flavoring, ethanol, sodium benzoate, glycerin and other substances. Loratadine tablets additionally contain microcrystalline cellulose, calcium stearate, corn starch, lactose monohydrate and other components that provide this drug with a solid form.

The auxiliary ingredients of the tablets from which the effervescent drink is made are lactose, citric acid, sodium carbonate and bicarbonate, as well as macrogol 6000, povidone, silicon dioxide (colloidal) and polysorbate 80. Thanks to such compounds, the drug retains its shape while in the tube, but quickly dissolves in water.

Operating principle

Loratadine blocks H1 receptors that are sensitive to histamine, which prevents this biologically active compound and other substances from being released from mast cells. This action prevents the development of an allergic reaction or alleviates allergy symptoms if they have already appeared. Taking Loratadine reduces the severity of itching, and also has an anti-exudative effect and reduces the permeability of small vessels, thereby reducing allergic edema. In addition, the drug has the ability to relax spasmodic smooth muscles.

The onset of the therapeutic effect of Loratadine can be seen within half an hour after use. The maximum effect develops 8-12 hours after administration and lasts up to 24 hours. This long-term effect on the body is associated with the formation of a substance called desloratadine during the metabolic changes of Loratadine, which also has antihistamine activity. At the same time, the medication does not pass through the blood-brain barrier, therefore it is unable to depress the central nervous system and cause addiction.

Indications

Loratadine can be prescribed to a child:

  • with allergic rhinitis;
  • with hay fever;
  • with Quincke's edema;
  • with urticaria;
  • with an allergic reaction to an insect bite;
  • with skin inflammation, which manifests itself as itching, as well as chickenpox;
  • with acute conjunctivitis;
  • with atopic dermatitis;
  • with false allergic reactions.

In addition, the drug is often prescribed for adenoiditis, pharyngitis, nasopharyngitis and similar diseases to reduce swelling of the mucous membrane.

At what age is it allowed to take it?

Loradatin is not prescribed to children under 2 years of age. A child over 2 years old can be given any of the medication options. At the same time, for the treatment of small children under 6 years of age, the liquid form (syrup) is more convenient, but if a younger child (4 or 5 years old) has no problems swallowing solid medicine, then he can also be given a tablet drug.

Contraindications

Loratadine should not be given not only to those under 2 years of age, but also if you are intolerant to any of the components of the selected form of the drug. The medicine has no other contraindications for children, and the medicine is not prescribed to adults during lactation or pregnancy.

Side effects

Taking Loratadine may cause decreased appetite, changes in stool, nervous agitation, dry mouth, nausea, drowsiness, sweating, hives, headaches and other negative symptoms. If they appear, the medicine is immediately discontinued.

Instructions for use and dosage

The drug is given to children once a day, determining the dosage according to the age of the little patient, as well as his weight:

  • If the child is under 6 years old or is older but weighs less than 30 kg, then the single dose of the drug is 5 mg. It is contained in 5 ml of syrup or half of Loratadine tablets. Effervescent tablets are not prescribed to children under six years of age and weighing less than 30 kg;
  • If the weight of a small patient is above 30 kg and his age is 6 years or more, then a single dosage for him will be 10 mg of loratadine. The patient can receive this dose from 2 measuring spoons of syrup (10 ml), one tablet or one effervescent tablet.

To prepare a drink from an effervescent tablet, you need to drop it in 200 ml of water and then drink the drug. Swallowing, sucking, or chewing Loratadine in this form is not recommended.

Overdose

If you give a child the drug in a larger dose than the doctor prescribed, this will lead to drowsiness and headaches, as well as tachycardia and motor neurological disorders. Having noticed an overdose, you should immediately induce vomiting in a small patient and give the baby a sorbent. If the child's condition worsens, it is necessary to show him to a doctor.

Interaction with other drugs

Loratadine is compatible with many medications, therefore it is often used in complex treatment for infectious diseases, increased acetone and other problems in which it is necessary to prevent or eliminate an allergic reaction. However, the medicine should not be given together with rifampicin, barbiturates, erythromycin and some other drugs indicated in the annotation for the tablets or syrup.

Terms of sale

All forms of Loratadine are over-the-counter drugs and therefore are freely sold in pharmacies. The price of the drug depends on the manufacturer, the dosage form, and the size of the package. For example, 10 Loratadine tablets cost about rubles, and a bottle of Loratadine-Akrikhin syrup costs about 150 rubles.

Storage conditions

Any form of Loratadine should be kept at home at room temperature in a place hidden from small children, dry and inaccessible to sunlight. The expiration date of the medicine differs from different manufacturers, so it should be clarified (data is available on the box of the purchased product). Often, syrup is stored for 3-4 years from the date of manufacture, and tablets - 3-5 years.

Reviews

In most cases, parents are satisfied with the treatment of children with Loratadine and note its high effectiveness in treating allergic reactions. Mothers most often choose syrup and praise this form for its pleasant taste and ease of use. The advantages of the medication in tablets include its small size, the need to take it only once a day, and its low cost.

Analogs

A complete replacement for Loratadine can be drugs that contain the same active ingredient, for example:

Many of them have a syrup or suspension form, which is convenient for treatment in childhood. In addition, your doctor may prescribe other antihistamines. This could be Suprastin, Diazolin, Tavegil, Zyrtec drops, Erius, Fenistil or another drug with a similar effect, but you should choose one of these drugs as an analogue of Loratadine together with your doctor. Since all of these medications include different active compounds, and some of them are not used at an early age, it is impossible to give any antihistamine to a child without consulting a pediatrician.

Watch the program of children's doctor Komarovsky, from which you will learn what anti-allergy medications can be used in a child.

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Source: http://www.o-krohe.ru/antigistaminnye-preparaty/loratadin-rebenku/

LORATADINE

Histamine H1 receptor . Has antiallergic, antipruritic, antiexudative effects. Reduces capillary permeability, prevents the development of tissue edema, reduces the increased contractile activity of smooth muscles caused by the action of histamine.

When taken orally in a therapeutic dose, loratadine is rapidly absorbed from the gastrointestinal tract and is almost completely metabolized in the body. Cmax of loratadine in plasma is achieved after 1-1.3 hours, the main active metabolite, descarboethoxyloratadine, after approximately 2.5 hours.

With simultaneous ingestion of food, the bioavailability of loratadine and descarboethoxyloratadine increases by approximately 40% and 15%, respectively, the time to reach Cmax increased by approximately 1 hour, its values ​​for these substances remained unchanged.

Plasma protein binding of loratadine is high - about 98%, the active metabolite is less pronounced.

On average, T1 /2 of loratadine is 8.4 hours, descarboethoxyloratadine is 28 hours (8.8-92 hours).

About 80% of loratadine is excreted in the form of metabolites in urine and feces in equal proportions within 10 days, about 27% in urine during the first day.

Orally for adults and children over 12 years of age, as well as for those weighing more than 30 kg - 10 mg 1 time / day.

Children from 2 to 12 years old with body weight less than 30 kg - 5 mg 1 time / day.

From the digestive system: rarely - dry mouth, nausea, vomiting, gastritis; in some cases - liver dysfunction.

From the side of the central nervous system: rarely - increased fatigue, headache, excitability (in children).

From the cardiovascular system: rarely - tachycardia.

Allergic reactions: rarely - skin rash; in isolated cases - anaphylactic reactions.

Dermatological reactions: in some cases - alopecia.

With simultaneous use of loratadine with drugs that inhibit the isoenzymes CYP3A4 and CYP2D6 or are metabolized in the liver with their participation (including cimetidine, erythromycin, ketoconazole, quinidine, fluconazole, fluoxetine), it is possible to change the plasma concentration of loratadine and/or these drugs.

Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, zixorin, rifampicin, phenylbutazone, tricyclic antidepressants) reduce effectiveness.

When using loratadine, the development of seizures cannot be completely excluded, especially in predisposed patients.

Patients with impaired renal or liver function require dosage adjustment.

Loratadine should not be used during pregnancy and lactation.

In experimental studies on animals, loratadine in medium doses did not have a negative effect on the fetus; when administered in high doses, some fetotoxic effects were observed.

To ask a question about the project or contact the editors, use this form.

Source: http://health.mail.ru/drug/loratadin/

Instructions for use of Loratadine syrup for children

Loratadine is an antiallergic drug that begins to act 20 minutes after administration and has a prolonged effect. The drug is available in the form of tablets and syrup; the latter type of medicine is intended for young children who find it difficult to swallow tablets. The medication is prescribed for allergic pathologies, as well as for some diseases that are accompanied by severe tissue swelling. Instructions for use of Loratadine syrup for children contain all the information necessary for the patient.

General description of the drug

Loratadine syrup belongs to the group of antihistamines. The active ingredient of the drug is loratadine, it contains 5 mg in 5 ml of the drug. In addition, the composition is supplemented with auxiliary components - propylene glycol, sodium benzoate, citric acid, sorbitol, alcohol, purified water and flavoring. The syrup looks like a colorless liquid with a light fruity aroma.

When used in a therapeutic dosage, it does not have a sedative effect. Even with long-term use of this drug, no changes in the functions of important organs and systems occur in patients. The drug has no pronounced effect on the overall activity of H2-histamine receptors. It has virtually no effect on the functioning of the heart.

After a single dose of Loratadine syrup, a noticeable antiallergic effect is observed after about an hour and a half. The maximum concentration of the drug in the blood can be achieved after 6 hours. The total duration of action of Loratadine is 24 hours.

The syrup is produced in bottles. Each is packaged in a cardboard box, along with instructions for use and a measuring spoon. The shelf life of the drug is 2 years, provided it is stored at a temperature of up to 25 degrees.

It is strictly forbidden to take a drug that has expired or has been stored incorrectly.

Pharmacokinetics

After administration, Loratadine is rapidly absorbed from the gastrointestinal tract. The absorption time may be affected by food intake, but this factor does not have a significant effect on the final result. The drug actively binds to blood proteins. The half-life of the drug is about 2 hours. Loratadine is excreted by the kidneys and intestines; the full period of elimination of metabolites can reach up to 10 days.

In patients with renal and hepatic insufficiency, the pharmacokinetics remain virtually unchanged. No changes are observed in older people either.

Indications

Prescribing Loratadine syrup for children is advisable for allergic diseases and pathologies that are accompanied by severe swelling of soft tissues and mucous membranes. The main indications for use are:

  • Allergic rhinitis, both seasonal and year-round.
  • Hay fever.
  • Hives.
  • Conjunctivitis.
  • Dermatitis and dermatoses.
  • Bronchial asthma.
  • Quincke's edema.
  • Reaction to various insect bites.

Loratadine for a runny nose is prescribed to reduce swelling of the mucous membrane and facilitate nasal breathing. In addition to rhinitis, the drug can also be prescribed for sinusitis. In this case, the drug also reduces nasal swelling, due to which the outflow of fluid from the paranasal sinuses is normalized.

Loratadine may be prescribed for sore throat and other throat pathologies. This drug is included in treatment to reduce swelling of the laryngeal tissue and prevent suffocation. The medicine must be taken simultaneously with other drugs prescribed by the doctor.

Loratadine is often prescribed simultaneously with antibiotics. This is necessary to prevent a severe allergic reaction in people with particular sensitivities.

Contraindications

Loratadine syrup may not be prescribed in all cases, as there are a number of contraindications. You should not take the drug for the following diseases and conditions:

  • In case of intolerance to the active substance or auxiliary components.
  • During pregnancy, as well as during breastfeeding.
  • For sucrase deficiency and fructose intolerance.
  • In case of severe renal and liver failure.

In addition, the drug is prescribed with caution to children under 2 years of age. This is due to the fact that the syrup contains alcohol, and the effect of the medicine on patients in this age group has not been well studied.

When prescribing Loratadine syrup to children under 2 years of age, the doctor compares all the possible risks of such treatment and the expected benefits. The dosage in this case is calculated individually.

How to use

Loratadine syrup is prescribed to patients in dosages that depend on the patient’s age and body weight.

  • Children weighing less than 30 kg are prescribed 5 ml of syrup per day once.
  • Children aged 7 to 12 years, but weighing up to 30 kg, are prescribed 10 ml of syrup once a day.
  • Adolescents, as well as adult patients, should take 10 ml of syrup once a day.

It is worth considering that the measuring spoon included in the box along with the bottle holds 5 ml of syrup.

No dosage adjustment is required for elderly people. There is no need to adjust the dose in patients with minor renal and hepatic impairment.

For patients with severe renal failure, the dose may be reduced. Most often, such patients are advised to take the medicine every other day.

Side effects

Typically, the drug is well tolerated by patients of all age groups. In rare cases, side effects are observed that may be associated with exceeding the dosage of the drug or taking too long of treatment. The most commonly observed adverse reactions are:

  • Headache.
  • Abnormal drowsiness (mainly when the dose is exceeded).
  • Insomnia.
  • Increased appetite.
  • Overexcitement.
  • Increased fatigue.
  • Tachycardia.

In addition, dyspepsia may occur - abdominal pain, nausea and dry mouth.

If any side effects occur, stop treatment immediately and consult a doctor.

Overdose

Since the syrup has a pleasant taste and smell, there is a high probability of overdose. Most often this happens if the medicine was left in a place accessible to the child. In case of an overdose, severe headache, drowsiness, rapid heartbeat and pale skin are observed.

As first aid, the victim’s stomach cavity is washed with a saline solution or a suspension prepared from water and crushed activated carbon tablets. After cleansing the stomach, the patient is given any sorbents.

After first aid is provided, the victim is taken to the hospital or an ambulance is called. The patient is given symptomatic treatment. The patient should remain under the supervision of a doctor for several days until the condition stabilizes.

In case of an overdose of any drug, the doctor must show the packaging of the medication. This will allow you to quickly make a diagnosis and prescribe the necessary treatment.

Features of application

In order for the treatment to be not only effective, but also safe, you should follow certain recommendations:

  • Loratadine syrup is prescribed with great caution to patients with severe renal or liver failure.
  • The drug contains sugar, so it should be taken with caution by patients with diabetes and people intolerant to certain types of sugars.
  • You should not take Loratadine two days before the expected date of allergy skin tests. This can significantly affect the results.
  • There is very little data on the effect of Loratadine on the body of a pregnant woman and the fetus, so for safety reasons it is better to refuse such treatment.
  • Loratadine can pass into breast milk and affect the baby. That is why doctors try not to prescribe the drug to nursing mothers.
  • The drug does not affect concentration and memory at all, so during treatment you can drive vehicles and work with complex mechanisms. However, patients should be warned that in rare cases severe drowsiness is possible. In this case, you should stop driving.

The drug should be prescribed with caution to children under 2 years of age. This is done only if the doctor does not see any alternative treatment. The dose of the drug and duration of treatment in this case are calculated individually.

When treating with antiallergic syrup Loratadine, you must strictly adhere to the recommendations of your doctor.

What to pay attention to

Before starting treatment, you must carefully read the instructions for use and strictly follow them. Particular attention should be paid to the following tips:

  • It is unacceptable to exceed the dosage of the drug prescribed by the doctor.
  • The antiallergic drug can be taken simultaneously with antibiotics and drugs of other groups. No significant clinical impact was identified in this case.
  • Loratadine does not enhance the effect of alcohol on the nervous system.
  • You should not take medicine that has expired, or one that has been stored incorrectly.
  • The medicine must be stored in its original packaging along with the instructions for use. You may need to re-read it at any time.
  • It is advisable to store the opened bottle of syrup on the refrigerator door. Before use, remove the medication from the refrigerator and keep it at room temperature for a couple of hours.
  • A child of any age should take medications only in the presence of adults. This will help avoid overdose and associated consequences.

The medicine must be shaken well before use.

If treatment with Loratadine syrup does not improve within a week, you should consult a specialist. Treatment in this case should be adjusted.

Loratadine is a time-tested antiallergic drug that can be used to treat adults and children. Loratadine is sold at a fairly reasonable price, which makes it especially popular among patients. For the treatment of young children, syrup is often prescribed. This medicine is easier for a child to drink, as it has a pleasant taste and aroma.

Source: http://pulmono.ru/lekarstva/dlya-nosa/instruktsiya-po-primeneniyu-siropa-loratadin-dlya-detej