Nasonex analog nasal drops

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Nasonex - instructions for use, analogs, reviews and release forms (spray or nasal drops) of a drug for the treatment of rhinitis, sinusitis, adenoids and polyps in adults, children and pregnancy

In this article you can read the instructions for use of the drug Nasonex.

Table of contents:

Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Nasonex in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Nasonex in the presence of existing structural analogues. Use for the treatment of rhinitis, sinusitis, adenoids and polyps in adults, children, as well as during pregnancy and lactation.

Nasonex is a glucocorticosteroid for topical use. Has anti-inflammatory and anti-allergic effects. The local anti-inflammatory effect of the drug is manifested when it is used in doses at which systemic effects do not occur.

Inhibits the release of inflammatory mediators. Increases the production of lipomodulin, which is an inhibitor of phospholipase A, which causes a decrease in the release of arachidonic acid and, accordingly, inhibition of the synthesis of arachidonic acid metabolic products - cyclic endoperoxides, prostaglandins. Prevents the marginal accumulation of neutrophils, which reduces inflammatory exudate and the production of lymphokines, inhibits the migration of macrophages, and leads to a decrease in the processes of infiltration and granulation. Reduces inflammation by reducing the formation of a chemotaxis substance (impact on late allergy reactions), inhibits the development of an immediate allergic reaction (by inhibiting the formation of arachidonic acid metabolites and reducing the release of inflammatory mediators from mast cells).

In studies with provocative tests with the application of antigens to the nasal mucosa, high anti-inflammatory activity of the drug was demonstrated, both in the early and late stages of the allergic reaction. When compared with placebo, a decrease in the level of histamine and eosinophil activity was found, as well as a decrease (compared to the baseline) in the number of eosinophils, neutrophils and epithelial cell adhesion proteins.

When administered intranasally, the systemic bioavailability of the drug is less than 0.1%. At the same time, mometasone furoate (the active substance of the drug Nasonex) is practically not detected in the blood plasma. A small amount of the active substance, which can enter the gastrointestinal tract during intranasal use, is absorbed to a small extent and is actively biotransformed during the “first pass” through the liver.

  • treatment of seasonal and year-round allergic rhinitis in adults, adolescents and children over 2 years of age;
  • exacerbation of chronic sinusitis in adults (including the elderly) and children over 12 years of age (as an adjuvant as part of complex antibacterial therapy);
  • prevention of moderate and severe seasonal allergic rhinitis (recommended 2-4 weeks before the start of the dusting season).

Dosed nasal spray (sometimes mistakenly called nasal drops).

Instructions for use and method of use

For the treatment of seasonal and year-round rhinitis, adults (including elderly people) and children over 12 years of age are prescribed 2 injections into each nostril once a day (total daily dose). After achieving the desired clinical effect, the dose of the drug for maintenance therapy is 100 mcg (1 injection into each nostril once a day). If necessary, the dose of the drug can be increased to 4 injections into each nostril (total daily dose kg). Children aged 2-11 years are prescribed 50 mcg (1 injection) into each nostril once a day (total daily dose).

Positive dynamics of clinical symptoms are observed, as a rule, within the first 12 hours after the first use of the drug.

For the treatment of exacerbations of chronic sinusitis as part of complex therapy with antibiotics, adults (including elderly people) and children over 12 years of age are prescribed 100 mcg (2 injections) into each nostril 2 times a day. Total daily dosage kg. If necessary, the daily dose can be increased to 800 mcg (4 injections into each nostril 2 times a day). After the symptoms of the disease decrease, a dose reduction is recommended.

Stereotypical drug delivery (in which each button press releases 100 mg of suspension, corresponding to 50 mcg of pure mometasone furoate) is established after approximately 6-7 “calibration” presses. If the drug has not been used for 14 days or longer, then recalibration is necessary before use.

The bottle must be shaken vigorously before use.

  • nosebleeds (i.e., obvious bleeding, as well as blood-stained mucus or blood clots);
  • pharyngitis;
  • burning sensation in the nose;
  • irritation of the nasal mucosa;
  • headache;
  • perforation of the nasal septum;
  • increased intraocular pressure.
  • children under 2 years of age;
  • untreated infection involving the nasal mucosa;
  • recent surgery or trauma to the nose (before the wound heals);
  • respiratory tuberculosis (including latent), untreated fungal, bacterial, systemic viral infection (including caused by the Herpes simplex virus with eye damage);
  • hypersensitivity to the drug.

Use during pregnancy and breastfeeding

There have been no special, well-controlled studies of the safety of Nasonex during pregnancy and lactation. After intranasal use of the drug at the maximum therapeutic dose, mometasone is not detected in the blood plasma even at the minimum concentration; therefore, fetal exposure to the drug can be expected to be negligible and the potential for reproductive toxicity to be very low.

However, during pregnancy and lactation, as well as in women of childbearing age, Nasonex should be prescribed if the expected benefit from its use justifies the potential risk to the fetus and newborn. Newborns whose mothers used corticosteroids during pregnancy should be carefully examined to identify possible adrenal hypofunction.

After using Nasonex for 12 months, there were no signs of atrophy of the nasal mucosa. A study of biopsy samples of the nasal mucosa revealed that mometasone furoate tended to normalize the histological picture.

When using the drug for a long time (as with any long-term treatment), periodic examination of the nasal mucosa by an ENT doctor is necessary. If a local bacterial or fungal infection of the nose or pharynx develops, it is recommended to stop treatment with the drug and begin specific therapy. Irritation of the mucous membrane of the nasal cavity and pharynx that persists for a long time is an indication for discontinuation of the drug.

With long-term use of the drug, no signs of suppression of the function of the hypothalamic-pituitary-adrenal system were observed.

Patients who switch to treatment with Nasonex nasal spray after long-term therapy with systemic GCS require special attention. Discontinuation of systemic GCS in such patients may lead to adrenal insufficiency, which may require appropriate measures.

During the transition from treatment with systemic corticosteroids to treatment with Nasonex nasal spray, some patients may experience withdrawal symptoms from systemic corticosteroids (for example, joint and/or muscle pain, fatigue, depression), despite a decrease in the severity of symptoms associated with damage to the nasal mucosa; such patients must be specifically convinced of the advisability of continuing treatment with Nasonex nasal spray. Changing therapy may also reveal previously developed allergic diseases, such as allergic conjunctivitis and eczema, that were previously masked by systemic glucocorticoid therapy.

Patients who have undergone GCS therapy have a reduced immune reactivity and should be warned about the increased risk of infection when in contact with patients with infectious diseases (including chickenpox, measles).

Use in pediatrics

In placebo-controlled clinical trials in children, when Nasonex was used at a dose of 100 mcg per day for a year, no growth retardation was observed.

There are no data on the use of the drug in children under 2 years of age, so Nasonex cannot be recommended for use in this age group.

The simultaneous use of Nasonex with loratadine did not lead to a change in the concentration of loratadine or its main metabolite in the blood plasma, and the presence of mometasone furoate in the plasma was not detected even at minimal concentrations.

Drug interaction studies of Nasonex with other drugs have not been conducted.

Analogues of the drug Nasonex

Structural analogues of the active substance:

Source: http://instrukciya-otzyvy.ru/190-nazoneks-po-primeneniyu-analogi-sprey-kapli-v-nos-rinit-sinusit-adenoidy-polipy.html

Nasonex

Description current as of 11/11/2015

  • Latin name: Nasonex
  • ATX code: R01AD09
  • Active ingredient: Mometasone furoate
  • Manufacturer: Schering-Plough Central East AG, Belgium

Compound

One dose of spray contains 50 mcg of anhydrous mometasone furoate and auxiliary components: dispersed cellulose (sodium carboxymethylcellulose and MCC), glycerin, citric acid, polysorbate-80, sodium citrate dihydrate, benzalkonium chloride solution, purified water.

Release form

  • Dosed spray Nasonex Sinus. Polyethylene bottles 10 g, packaging No. 1. Each bottle is equipped with a protective cap and a spray nozzle. The contents of the bottle are designed for 60 doses, each of which contains 50 mcg of active substance.
  • Nasonex metered spray. Polyethylene bottles 18 g, packaging No. 1. Each bottle is equipped with a protective cap and a spray nozzle. The contents of the bottle are designed for 140 doses, each of which contains 50 mcg of active substance.

The contents of the bottle are an opaque suspension of almost white or off-white color.

pharmachologic effect

The drug has anti-inflammatory activity and has an antiallergic effect.

Pharmacodynamics and pharmacokinetics

Nasonex - hormonal or not?

The active substance of the spray is a synthetic corticosteroid for local (inhalation) use, therefore, the drug Nasonex is hormonal.

Pharmacodynamics

A feature of mometasone furoate is its ability to relieve inflammation and inhibit the development of an allergic reaction, even when used in doses at which systemic effects do not develop.

The substance inhibits the release of inflammatory mediators, stimulates the production of lipomodulin, which is an inhibitor of phospholipase A. Due to this, the release of arachidonic acid is reduced and, accordingly, the synthesis of its metabolic products (Pg and endoperoxides) is suppressed.

Reduces the formation of a chemotaxis substance, influencing “late” (delayed) allergic reactions, and also prevents the development of an immediate allergic reaction.

Studies with provocative tests with the application of antigens to the nasal mucosa have shown that Nasonex nasal spray exhibits high anti-inflammatory activity both at the early and late stages of the development of an allergic reaction.

This is confirmed (compared to placebo) by a decrease in eosinophil activity and histamine levels, as well as a decrease (compared to the baseline) in the number of neutrophils, eosinophils and epithelial tissue cell adhesion proteins.

In approximately a third of patients (28%) with seasonal allergic rhinitis, a pronounced clinical effect was achieved within twelve hours after the first inhalation. In half of the patients, improvement occurred on average within 1.5 days (35.9 hours).

In addition, in patients suffering from seasonal runny nose, the drug showed significant effectiveness in reducing the severity of eye symptoms (itching, lacrimation, redness).

Pharmacokinetics

The bioavailability of mometasone when applied topically is negligible (does not exceed 0.1%).

The substance is practically undetectable in blood plasma. The suspension is very poorly absorbed from the digestive canal, and the small amount that can be swallowed and has time to be absorbed undergoes active metabolism even before excretion.

Metabolites are excreted primarily in bile and, in small quantities, in urine.

Indications for use

Indications for use of Nasonex are:

  • allergic rhinitis (seasonal or year-round) in children, adolescents and adults;
  • exacerbation of chronic sinusitis (the drug is prescribed as an adjunct to antibiotic therapy) in adolescents and adults;
  • prevention of moderate/severe seasonal allergic rhinitis (it is considered optimal to start using the spray no later than 2 weeks before the expected start of the dusting period).

Children are prescribed Nasonex allergy spray from the age of two. For the treatment of sinusitis in pediatrics, it is used in children over twelve years of age.

Contraindications

Contraindications to the use of Nasonex are:

  • intolerance to any of its constituent components;
  • the presence of an untreated/undertreated local infection, provided that the nasal mucosa is involved in the process;
  • active or latent tuberculosis infection of the respiratory tract;
  • untreated bacterial, systemic viral or mycotic infection, as well as an infection caused by the herpes simplex virus with eye damage (in some cases, the drug can be prescribed as an exception as directed by the attending physician).

If the patient has recently suffered a nasal injury or nasal surgery, the use of the spray is contraindicated until the wound has healed.

Side effects

When treating allergic rhinitis in adults, the following are possible:

  • pharyngitis;
  • nosebleeds (bleeding may be obvious or blood may be present in the mucus released from the nose);
  • irritation of the mucous membrane in the nasal cavity;
  • burning sensation in the nose.

In children receiving Nasonex for the treatment of allergic rhinitis, the following was observed:

  • nosebleeds;
  • irritation of the nasal mucosa;
  • headache;
  • sneezing.

Nosebleeds usually stop on their own and are not severe. They occur with a frequency comparable to the frequency of their occurrence when using placebo (5%), but less or equal than when using other glucocorticosteroids for intranasal use.

Nasonex analogues were used for active control; with their use, the incidence of nosebleeds was up to 15%.

Other adverse reactions in the group of patients receiving mometasone developed with the same frequency as in patients who received placebo.

When prescribing the drug for sinusitis/sinusitis, when Nasonex is used as an adjuvant to relieve swelling of the drainage holes, reduce secretion production and facilitate the discharge of mucus from the paranasal sinuses, the following were recorded in adolescents and adults:

Bleeding was moderate, and the frequency of its occurrence when using the spray was only slightly higher than the frequency of its occurrence when using placebo (5% and 4%, respectively, for Nasonex and placebo).

Cases of development of ocular hypertension or perforation of the nasal septum have been reported extremely rarely when using endonasal corticosteroids.

Nasonex spray: instructions for use

General recommendations

The drug is intended for intranasal administration (used in the form of inhalations) of the suspension contained in the bottle. The procedure is carried out using a dosing nozzle, which is supplied with each bottle of Nasonex.

Before using the spray for the first time, it is “calibrated” by pressing the dosing device 6-7 times. “Calibration” allows you to establish a stereotypical supply of medicine. In this case, each press of the dosing device ensures the release of 100 mg of suspension into the nasal cavity, which contains 50 mcg of a chemically pure active substance.

Before use, the bottle must be shaken vigorously each time.

Instructions for use of Nasonex/Nasonex Sinus for allergic rhinitis

The standard prophylactic/therapeutic dose for adolescents over the age of twelve and adult patients (including the elderly) is two inhalations into each nasal passage as a single dose (200 mcg of mometasone per day).

After achieving the desired therapeutic effect, the dose is reduced to 100 mcg/day. (one inhalation in each nasal passage once).

If it was not possible to achieve the desired effect when using a therapeutic dose, the dose can be increased to 400 mcg/day. That is, the patient should take up to four inhalations once in each nasal passage. Reducing the severity of symptoms of allergic rhinitis is an indication for dose reduction.

Clinical improvement after the first use of mometasone is usually noticeable within 12 hours after the first inhalation.

For children under 11 years of age, it is recommended to take one inhalation into each nasal passage once for allergies. Total dose kg/day.

Since Nasonex is not a nasal drop, but a spray, when inhaling, you should keep your head straight, without throwing it back.

Instructions for Nasonex Sinus and Nasonex for exacerbation of sinusitis

For patients over twelve years of age, including the elderly, the recommended therapeutic dose is two inhalations into each nostril, 2 times a day. Total dose kg/day.

The drug is used as an adjuvant, complementing the main treatment.

If clinical improvement cannot be achieved using the drug at a standard dosage, the dose may be increased to 800 mcg/day. (four inhalations into each nasal passage, 2 times a day). After the severity of symptoms decreases, the dose should be reduced.

After 12 months of use of Nasonex, there were no signs of atrophy of the nasal mucosa; in addition, mometasone tended to improve the histological picture when examining a tissue sample of the nasal mucosa.

Nasonex for adenoids

Enlarged adenoids are a fairly common complication of allergic rhinitis in young children. Prescribing Nasonex to children with adenoids can relieve swelling and often prevent the need for surgical intervention.

Reviews of Nasonex for adenoids indicate that the effect is achieved by suppressing lymphoid tissue, but it takes quite a long time to achieve it. In addition, in cases of severe inflammation, the drug is not very effective.

As a hormonal agent, the spray also additionally suppresses local immunity, and therefore, after its discontinuation, inflammation in the adenoids may resume. External manifestations of inflammation are the appearance of mucus flowing down the back wall of the throat.

To relieve this condition, doctors recommend taking a course of anti-inflammatory treatment for adenoid vegetations. In this case, inhalations through a nebulizer with Cycloferon, supplemented by rinsing the nasopharynx using the nasopharyngeal shower method, which are carried out in an ENT office, may be effective.

Dr. Komarovsky recommends, as an addition to the treatment of adenoids, to reconsider the organization of the child’s lifestyle. Since one of the causes of enlarged adenoids is decreased immunity, it is very important that the immune system functions as well as possible.

To minimize the risk of an increase in the size of the pharyngeal tonsils, the child should eat properly, walk in the fresh air, temper himself, play sports and have as little contact as possible with household chemicals and dust.

After the inflammation disappears, it is usually not necessary to repeat the course of intranasal GCS.

Overdose

An overdose of mometasone develops with prolonged use of the drug in high doses, as well as in the case of simultaneous use of several corticosteroids. As a result, the function of the hypothalamic-pituitary-adrenal system may be inhibited.

The systemic bioavailability of mometasone is extremely low, so it is unlikely that in case of an intentional/accidental overdose, it will be necessary to take any measures other than monitoring the patient and then continuing to use Nasonex at the recommended dose.

Interaction

Patients tolerate combination therapy with Loratadine well. Drug interactions with other drugs have not been studied.

Terms of sale

Storage conditions

The spray bottle should be stored at a temperature of 2-25°C. Freezing the drug is unacceptable.

Best before date

special instructions

The bottle is calibrated. If the product is not used for more than 14 days, recalibration is required.

With long-term (several months) use of the spray, you should undergo periodic examinations by an otolaryngologist for possible changes in the nasal mucosa. If a local mycotic infection of the pharynx/nose develops, you should stop using Nasonex or undergo a course of special treatment.

Particularly careful medical supervision is required for patients who use Nasonex simultaneously with systemic corticosteroids, as well as patients to whom the drug was prescribed after discontinuation of corticosteroid therapy.

Withdrawal of systemic corticosteroids often leads to adrenal insufficiency, which may require appropriate measures. When switching from systemic corticosteroids to the use of a nasal spray, some patients may experience symptoms of corticosteroid withdrawal:

A change in therapy may cause symptoms of previously developed allergic diseases (for example, eczema or allergic conjunctivitis), which were previously masked by systemic glucocorticosteroid therapy.

In patients receiving treatment with corticosteroids, immune reactivity is potentially reduced. For this reason, they should be warned about the increased risk of infection if they come into contact with an infectious patient (including people with measles or chickenpox), and about the need to consult a doctor if such contact occurs.

In placebo-controlled trials in children, when the drug was used at a dose of 100 mcg for a year, growth was delayed in children. Also, with prolonged use of Nasonex, there are no signs of suppression of the function of the hypothalamic-pituitary-adrenal system.

In cell culture, mometasone furoate showed tenfold greater activity compared to other steroids, including Betameson, Dexamethasone, beclomethasone dipropionate, in suppressing the synthesis/release of interleukins (IL) 1, 5 and 6, TNF-α, as well as IL-4, IL- 5 and Th2 cytokines from human CD4+ T cells.

By suppressing the production of IL-5, the drug exhibits six times greater activity than betamethasone and beclomethasone dipropionate.

What can replace Nasonex?

What analogues are cheaper than Nasonex?

The price of Nasonex analogues is from 128 rubles. The most inexpensive substitute for Nasonex is Desrinit nasal spray.

What is better Nasonex or Avamis?

Avamys is available in the form of an aqueous spray for intranasal administration. Its active substance is fluticasone furoate (the concentration of the substance in one dose is 27.% 5 mcg).

Fluticasone and mometasone are the most modern drugs, which are characterized by a very high degree of affinity for GCS receptors and exceptional topical activity.

Both substances have extremely low absolute bioavailability. However, for mometasone this figure is slightly lower than for fluticasone - 0.1% versus 0.5%.

Among all existing corticosteroids for intranasal administration, mometasone has the lowest bioavailability and the fastest development of the therapeutic effect.

In addition, its use is permitted from the age of two, while fluticasone furoate in pediatric practice is used only for the treatment of children over six years of age. Even with long-term use, mometasone does not have a negative effect on the growth of the child.

Nasonex or Flixonase - which is better?

Flixonase is an endonasal aqueous spray based on micronized fluticasone propionate. The concentration of the active substance in one dose is 50 mcg.

The drug has a rapid anti-inflammatory effect on the nasal mucosa, and its anti-allergic effect appears 2-4 hours after the first inhalation.

The effect (in particular, reduction of nasal congestion) persists for 24 hours after a single administration of Flixonase at a dose of 200 mcg.

When used in therapeutic doses, the drug does not have any pronounced systemic activity and almost does not inhibit the hypothalamic-pituitary-adrenal system.

Systematic reviews of the comparative effectiveness and safety of fluticasone propionate and mometasone furoate conducted as part of the DERP project showed that the differences in their effectiveness are very small. However, it should be borne in mind that fluticasone propionate is characterized by higher bioavailability than mometasone. This figure varies from 0.5 to 2%.

It is significant that Flixonase in pediatrics can only be used from the age of four.

Results from studies conducted by the FDA showed that the reduction in the severity of symptoms of allergic rhinitis as assessed by patients in the fluticasone group was more pronounced (45%) compared with the mometasone group (36%) and the placebo group (11%).

Patients receiving fluticasone were less likely than patients receiving mometasone and placebo to use additional medications (eg, nasal constrictors) for relief: rates of use were 42%, 47%, and 58%, respectively, for fluticasone, mometasone, and placebo.

Side effects when using fluticasone were also recorded less frequently (in particular, pharyngitis and gastrointestinal disorders),

What is better Nasonex or Nazarel?

The active substance of Nazarel spray is fluticasone propionate (50 mcg/dose), therefore, comparing the effectiveness of the drug with the effectiveness of Nasonex, we can say that, as in the case of Flixonase and Avamys, it is comparable.

The research results and subjective feelings of patients taking different endonasal corticosteroids confirm that both drugs are effective and safe. However, the advantage of Nazarel is its significantly lower cost (about rubles for 120 doses).

Nasonex during pregnancy

After administration of the drug into the nasal cavity in the maximum permissible therapeutic dose, its active substance is not detected in the blood even in the minimum concentration.

Thus, its potential reproductive toxicity (including effects on male/female fertility and effects on the developing organism) is negligible.

However, due to the fact that well-controlled studies of the effect of mometasone furoate on the body when used during pregnancy and lactation have not been conducted, the spray should be prescribed to pregnant women, mothers who are breastfeeding, and women of childbearing age only in those cases. cases where the expected effect of therapy justifies the potential risk to the fetus/newborn.

Newborn infants whose mothers received corticosteroids during pregnancy should be examined for possible hypofunction of the adrenal cortex.

Reviews of Nasonex

Reviews of Nasonex Sinus/Nasonex are mostly good. More than 80% of patients who used the drug noted a very rapid improvement in their condition, calling the drug an indispensable assistant in the fight against seasonal and year-round allergic rhinitis.

Moreover, some patients who have been on vasoconstrictor drugs for years claim that it was Nasonex spray that helped them get rid of this addiction.

However, there are also those for whom the drug did not suit or did not give the expected result, which may be due to the body’s individual reaction to the prescribed treatment.

A separate group of reviews are reviews of Nasonex for children. For children, the spray is most often prescribed for adenoids, if the proliferation of lymphoid tissue is a consequence of allergies. Despite the fact that the drug is hormonal, mothers believe that it is better to undergo treatment with it than to send the child for surgery.

If we talk about the effectiveness of Nasonex for adenoids, then positive dynamics become noticeable quite quickly, but only if the treatment regimen is chosen correctly.

The big advantage of the drug is that its active substance is absorbed in negligibly small quantities and does not have systemic activity. Thanks to this, Nasonex, unlike most analogues, can be used from the age of two.

It should be noted that there are, although extremely rare, reviews in which mothers who used Nasonex to treat their child complain that after the end of the course of treatment, all the old drugs that were prescribed to the child before do not work and do not even provide temporary relief.

Doctors' reviews of Nasonex allow us to conclude that endonasal corticosteroids do not completely cure polypous rhinosinusitis and allergic rhinitis, but are able to completely - and as quickly as possible - relieve the symptoms of allergic rhinitis and significantly delay the timing of relapse of nasal polyp growth.

Drugs in this group are the only drugs whose clinical effectiveness in chronic polypous rhinosinusitis is confirmed by evidence-based medicine.

How much does Nasonex cost?

Price in Ukraine

Price of Nazonex Sinus (60 doses) in large cities of Ukraine (Kharkov, Kyiv, Dnepropetrovsk, etc.) UAH. You can buy Nasonex (drops, 140 doses) for an average of 485 UAH.

Nasonex price in Russian pharmacies

The price of Nasonex Sinus spray in St. Petersburg and Moscow is from 440 rubles, the cost of a bottle containing 120 doses of the drug is from 780 rubles.

Additionally

The manufacturer does not produce Nasonex nasal drops. The only dosage form of the drug is a metered-dose nasal spray.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Ukraine Ukraine
  • Online pharmacies in Kazakhstan Kazakhstan

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Substitutes for Nasonex nasal spray for children and adults - list of drugs with descriptions, composition and prices

In case of allergic rhinitis, it is appropriate for a child to use Nasonex nasal spray according to the instructions - analogues are also highly effective and help solve the health problem that has arisen. Before making a choice, you need to consult with your doctor, especially when it comes to a child’s body. Nasonex and analogues are especially popular in ENT practice, as they eliminate a runny nose and internal discomfort in the shortest possible time. All that remains is to choose the most effective medicine in a given direction.

What is Nasonex

This representative of the group of glucocorticosteroids is necessary for intranasal use. The active ingredient is mometasone furoate. In the body it demonstrates anti-inflammatory, immunostimulating, antibacterial, antiallergic properties, and provides a local effect directly on the pathological site. The active component in small concentrations is absorbed into the systemic circulation, disintegrates in the liver, and is excreted by the kidneys. The drug has non-toxic pharmacological properties, so the list of side effects is not extensive.

The medication is prescribed for allergic rhinitis, sold in pharmacies, and sold without a prescription. Nasonex is produced in the form of a water-based nasal spray, intended for external use. Recommended for other allergic diseases that are accompanied by a severe runny nose, sore throat, and rhinitis. With long-term use of hormonal drugs, doctors prescribe alternating medications, avoiding the “addictive effect.” In this way, you can suppress inflammatory processes, speed up the removal of infection and ensure recovery.

Instructions for use

If symptoms of allergic rhinitis suddenly arise, the first step is to determine the etiology of the pathological process in a laboratory and eliminate the provoking factor. Then the patient is prescribed conservative treatment, which includes Nasonex nasal drops or its analogues for a full course. For intranasal use, daily doses of a typical medication are presented in detail below:

  • children 2-12 years old - 2 injections into each nostril once a day (preferably at the same time) for 5-7 days;
  • patients over 12 years of age and adults - 2 injections into each nostril twice a day - preferably in the morning and evening;
  • for chronic sinusitis, Nasonex is prescribed in combination with antibiotics in a volume of 2-4 injections into each nostril twice a day for a week;
  • if the symptoms of the disease characterize a severe pathological process in the body, it is recommended to take Nasonex in a high dose - 4 injections into each nostril a week;
  • Before using the medicine, the bottle must be shaken well, a control injection into the air must be performed, and after use, the medicine must be stored in the refrigerator, in a dark place;
  • the period of use of Nasonex spray is about 5-7 days, after which you need to take a break and individually adjust the daily dosage according to indications;
  • there is a drug interaction, and this fact must be taken into account when choosing a complex treatment regimen for rhinitis or another disease with symptoms of a runny nose.

Analogs

If the medicine is not suitable, or turns out to be ineffective in relation to the focus of the pathology, doctors prescribe an analogue of Nasonex Desrinit or another medicine as part of GCS therapy. For example, such a replacement is necessary when nosebleeds occur, in chronic diseases of the adrenal glands, or in the complete absence of an antiallergic effect. Before ordering one of Nasonex's analogues, if you have an allergic disease, it is recommended to consult with your doctor.

Cheaper analogue of Nasonex

If it is decided to urgently replace Nasonex, the price of the analogue is also of great importance for the patient. I would like to get an effective medical drug of a budget option that will act effectively and without side effects. Among the local glucocorticosteroids, the following medications are cheap; instructions for use are included in each package:

Nasonex analogue for children

This medication is prescribed in pediatrics for the treatment of adenoids. The use of a nasal spray is appropriate in childhood; the main thing is to choose an effective and hypoallergenic composition. In case of an allergic disease, it is recommended to first study the components of the drug in order to ultimately achieve the desired clinical effect without complications and health problems. It is also important to take into account the patient’s age and the cost of the supposed favorites. In case of exacerbation, effective analogues appropriate for children are presented below:

Review of effective analogues

If after long-term therapy Nasonex does not help, the doctor recommends an analogue. The list of medications of this pharmacological group is extensive; buying a medicine in an online store from a catalog will be much more profitable. Since Nasonex is a hormonal drug, in practice there are cases of a gradual weakening of the therapeutic effect upon repeated administration. The body, living on medicinal substances, adapts and develops the so-called “acquired immunity to chemistry.” This is where the urgent need for analogues arises.

Mometasone spray

A typical medication has an antiallergic effect in the body, relieves itching and inflammation. The active component is mometasone furoate, which has a concentration of 50 mcg per 100 ml of the drug. The use of intranasal inhalations enhances the therapeutic effect if antibiotics are additionally used. By regularly treating the lining of the nasal passages, nasal breathing becomes easier and allergy symptoms disappear. The use of nasal spray is allowed only on the recommendation of the attending physician.

Desrinitis

The Israeli medicine Dezrinit is an excellent remedy for acute and chronic runny nose. This pharmacological prescription is appropriate for obstructive pulmonary disease and bronchial asthma. The active component is mometasone furoate monohydrate, which has anti-inflammatory, antiallergic and antipruritic properties. It is recommended for use by adults and children, especially with seasonal allergic reactions of the body. When choosing Nasonex or Desrinit spray, it is advisable to give preference to the second medication with a gentle effect in the body

Avamis

This English analogue of Nasonex is used to treat allergic rhinitis and is approved in childhood and pregnancy. Reviews of the therapy completed with his participation have only positive content. If Nasonex was prescribed, but the medication was not suitable for a particular clinical picture, this is an inexpensive replacement with identical pharmacological properties. There are almost no side effects during treatment, and you can finally get rid of the unpleasant signs of allergic rhinitis.

Flixonase or Nasonex - which is better?

Both drugs have a pronounced anti-inflammatory effect and contain synthetic components in their chemical composition. The choice must be made in favor of the favorite. Voicing a list of analogues, the specialist recommends Flixonase spray. It is much more effective, but the price is much higher. Among systemic glucocorticosteroids, this is the best representative, thanks to which systemic measures are carried out that can stabilize the patient’s general condition in the shortest possible time.

Nasobek or Nasonex - which is better?

I examine the nasal mucosa; the otolaryngologist can detect polyps. Using Nasonex spray is not always effective, so doctors prescribe a more effective analogue - Nasobek. This is a nasal spray, which is indicated for treating the nasopharyngeal cavity twice a day for 7-10 days. Longer treatment is not recommended, since the therapeutic effect will weaken, and an analogue from the pharmacological group of GCS will again be required. In addition, in this way you can completely get rid of the systemic effects of allergies and provide reliable prevention of seasonal rhinitis.

Nasonex or Nazarel - which is better?

For rhinitis of various etiologies, it is better to use special sprays to treat the mucous membranes of the nasal passages than nasal drops. This is explained by the extensive area of ​​irrigation of the affected surface. Nasonex and Nazarel operate on the same principle and are complete analogues. However, the cost of Nazarel is 20% lower. This medicine can be safely prescribed even to a child, but at the same time do not violate the daily dose and do not delay the duration of the treatment course.

Many young parents know how much Nasonex costs, and consider this price too high. Therefore, they are looking for a more affordable alternative with a high therapeutic effect for their child. Such a replacement can be introduced only with the permission of the local pediatrician, otherwise complications may include not only local and allergic reactions, but also nosebleeds, dry mucous membranes, etc. In the online store, prices are more affordable, delivery is fast, and regular customers also get discounts. So the choice is up to the buyer.

The final prices of Nasonex spray and its full analogues in real pharmacies in Moscow are presented in detail below, however, the medications themselves for external use should not become a means of superficial self-medication for a clinical patient. A consultation with an otolaryngologist will not be superfluous. So:

Name of the medicine

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The information presented in the article is for informational purposes only. The materials in the article do not encourage self-treatment. Only a qualified doctor can make a diagnosis and make recommendations for treatment based on the individual characteristics of a particular patient.

Source: http://sovets.net/13138-nazoneks-analogi.html

Nasonex - analogues

Despite the fact that side effects when using the drug Nasonex occur relatively rarely, in some cases they are possible.

When should Nasonex be replaced?

The most common undesirable manifestations are:

  • nosebleeds;
  • pharyngitis;
  • increased intraocular pressure;
  • malfunction of the adrenal glands.

There are contraindications to the use of Nasonex related to:

  • with the patient's childhood;
  • tuberculosis of the respiratory system;
  • hypersensitivity to the components of the drug.

In addition, it is prohibited to use the drug after a nasal injury or surgery on the nasopharynx.

In all of these cases, it is necessary to replace Nasonex with analogue drugs. Let's look at what medications similar to Nasonex spray are recommended for use by experts.

Analogues of the drug Nasonex

The list of drugs analogous to the active substance of Nasonex spray is quite impressive. Among the structural analogues it should be noted:

The active ingredients contained in these medicinal analogues of Nasonex have a similar effect, so the decision on the use of a particular drug is usually made by the attending physician. Sometimes the cost of the drug is decisive in choosing a medicine. Currently, Nasonex costs approximately 6 USD. Let's consider the comparative characteristics and cost of ointments and nasal drops that are analogues of Nasonex.

Avamys spray, produced in the UK, is perhaps the most famous of Nasonex analogues. The drug also has anti-inflammatory and antiallergic effects. Avamis can replace Nasonex if increased reactivity is observed when using the latter. For many, price is significant when choosing one of the sprays, and they prefer Avamis for this reason. Its cost is approximately 20% lower.

The active substance in Nazarel spray is fluticasone propionate. Experts emphasize that the effectiveness of Nazarel and Nasonex is approximately the same. But Nazarel costs around 5 USD, so we can say that its price is about % lower.

The Israeli drug Dezrinit is a spray intended for intranasal and inhalation use for allergic manifestations and inflammatory processes in the nasopharynx. The indications for use of Dezrinit and Nasonex are similar, but in addition, Dezrinit is used in the form of inhalations in the treatment of bronchial asthma and COPD (chronic obstructive pulmonary disease). The cost of the drug Desrinit is comparable to the price of Nasonex, and ranges from 5 to 6 USD.

Flixonase nasal spray is also a British-made pharmaceutical product. An aerosol drug is used for the prevention and treatment of seasonal and year-round allergic rhinitis. The cost of Flixonase is almost twice as high as that of Nasonex (approximately 10 USD).

Uniderm is a drug in which the active substance is mometasone, as in Nasonex. The product is available only in the form of a cream, therefore it is not suitable for use in the treatment of respiratory organs, but is used exclusively for skin allergic diseases.

Gistan N is a 0.1% cream made in India, used for allergy symptoms. When compared by price, a tube of Gistan N costs much less than Nasonex aerosol. Now the price of the drug Gistan N is less than 2 USD.

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Source: http://womanadvice.ru/nazoneks-analogi

Characteristics of Nasonex and its replacement with analogues that cost less

Adenoiditis is a previously unknown word to science, but today it is the most common disease in children.

From birth and during active physical development, the child’s nasal sinuses have an imperfect structure. The nasopharynx begins to expand only by 5-6 years. Before this age, any child is susceptible to frequent colds. And if adults save themselves from colds with drugs like Theraflu, then with children the issue becomes more complicated, because such medications are strictly prohibited for them.

Modern ecology is far from perfect. Mutation of viruses leads to the fact that even the most popular and expensive vaccinations do not save our children from viruses entering the body.

The medical industry does not stand still - more and more new drugs for children are released every month. And parents often face a difficult choice - which medicine is best to buy with such a variety?

Nasonex - expensive but effective

Nasonex is rightfully recognized as one of the best drugs for the treatment of adenoiditis in children.

This is a Belgian-made spray.

But its considerable cost is fully justified.

With the help of Nasonex you can cure many diseases of the nasopharynx:

  • adenoiditis;
  • sinusitis;
  • sinusitis;
  • seasonal and periodic allergies;
  • rhinitis;
  • polyps in the nose and paranasal sinuses.

This drug is approved for use by children over two years of age.

The main active ingredient is mometasone furoate, an active pure hormone. Since the drug contains active hormones, it is recommended to use it in children only in the presence of serious illnesses and on the mandatory recommendation of the attending physician.

Nasonex is taken for acute forms of inflammation of the nasopharynx, polyps, allergic rhinitis, and sinusitis. It is especially effective in treating stages 2-3 of adenoiditis in children, so replacement is cheaper for adenoids and is often not recommended by the attending physician.

Nasonex should be used with caution in children under 2 years of age, women during pregnancy and lactation, and elderly people who react acutely to hormones.

A distinctive feature of this drug is the beginning of its effect on the body. If other nasal sprays begin their therapeutic effects after a few days, then the effect of Nasonex can be noticed after 12 hours.

A child suffering from severe adenoid disease is practically unable to breathe on his own. At the very first use of Nasonex, children experience positive dynamics - the nasopharynx expands, providing maximum air permeability.

In addition to Nasonex, there are analogues that are a replacement for the drug and are cheaper. For most of the population, price is a decisive factor when choosing drugs, so let’s look at a list of drugs with prices in rubles.

Flixonase

This drug is a replacement for Nazones and is slightly cheaper.

Flixonase is purchased when Nasonex itself cannot be found in pharmacies.

These 2 drugs are easily comparable, have almost the same effect and contain similar substances.

The only difference is that Flixonase is allowed only from 4 years of age, while Nasonex can be taken from 2 years of age.

Price – rubles.

The doctor prescribed Flixonase to eliminate dependence on Nazivin. I am more than satisfied with the result, I recommend the product. And in order to get less pain, Imudon was prescribed. Since then I have spent less on medications.

The spray may help, but unfortunately, we experienced a whole bunch of side effects. My daughter (6 years old) started bleeding from her nose due to Flixonase; the doctor told her to stop taking the drug immediately.

Avamis

Also used in the treatment of adenoids, seasonal rhinitis and some forms of allergies.

Avamys is much cheaper than Nasonex and has a similar effect on the body.

Approved for children over 2 years of age.

It is available in the form of a spray atomizer, which allows for a convenient dosage and spraying the drug directly onto the site of inflammation.

Avamis is recommended by many doctors, considering it one of the most effective medicines for the treatment of allergies and rhinitis. In addition, Avamis has an excellent effect on many types of viruses and has virtually no contraindications, which is why it is so often prescribed to young children.

The price of the drug is from 500 rubles.

Olga, Yegoryevsk

I suffered from a runny nose for a long time, and doctors could not determine the cause. I was treated with Polydexa myself, but it didn’t help. As a result, they diagnosed an allergy, but to what exactly, they never found out. Avamis was appointed along with Tavegil. Already on the first day of taking Avamys helped me. On the fourth day, the swelling completely disappeared, and a week later all symptoms disappeared.

Anna, Naberezhnye Chelny

Prescribed for a child (2 years old) for allergic rhinitis along with the drug Zodak. Four days later we went to the garden.

Nazarel

Produced in Israel and the Czech Republic.

It is a cheaper analogue of Nasonex.

The drug is identical both in active substances and in its effect on the body.

Allowed from 4 years.

The average price is 400 rubles, in inexpensive pharmacies you can find it for 350.

I was looking for a replacement for Nasonex for a long time and settled on Nazarel. Excellent drug! The allergy went almost unnoticed, the spray was used every 4 hours. It's completely gone in 5 days!

The daughter suffered from grade 3 adenoiditis. We used Nazarel. The effect is zero. Nasonex cured all the growths and reduced the adenoids to normal size. I recommend this drug to everyone! It is expensive, but the price is completely worth it.

Nasobek

The active substance is beclomethasone.

The drug contains less active hormones and does not treat all nasal diseases in children.

For example, in cases of severe allergies or stages 3-4 of adenoid proliferation, it is practically useless, while Nasonex successfully copes with these types of diseases.

Nasobek price – from 160 rubles.

Margarita, Vorkuta

Having a 3-year-old child in your arms, it is difficult to find any medicine that can cure sinusitis in a few days. But Nasobek successfully completed the task assigned to him. We went to the garden in 5 days!

Sofia, Taganrog

They prescribed us Nasonex. I went to three pharmacies and it was out of stock. They offered it to order, but this is another two or three days of torment for the child. As a result, on the advice of the pharmacist, I took Nasobek. I am completely satisfied with the effect of the drug, so I see no reason to overpay.

What to prefer

How to make the best choice in favor of one medicine or another when it comes to treating a child? The answer is clear: only a pediatrician can prescribe treatment. The local therapist or pediatric otolaryngologist, after examining your child, will prescribe the necessary treatment.

Of course, it is difficult to find a complete replacement for Nasonex. Therefore, put yourself before a choice: child’s health or savings?

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Reviews for the entry: Characteristics of Nasonex and its replacement with analogues that cost less

I bought Nazonex, no effect, just water, that’s how they deceive us and the price is 500 rubles. Who will return my money

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