Tobrex eye drops composition

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Tobrex

Description current as of 05/12/2014

  • Latin name: Tobrex
  • ATX code: S01AA12
  • Active ingredient: Tobramycin
  • Manufacturer: Alcon-Couvreur NVSA; Rijksweg 14, B-2870 Puurs, Belgium

Compound

1 ml of solution contains 3 mg of tobramycin as the main substance, and also contains benzalkonium chloride, boric acid, sodium sulfate, sodium hydroxide or sulfuric acid (to stabilize the pH level), tilaxopol, and purified water as excipients.

Table of contents:

Release form

Available in the form of a transparent, colorless or straw-colored solution in Drop Tanner dropper bottles of 5 ml with the possibility of dosing. 1 bottle in a cardboard box.

pharmachologic effect

Tobramycin is an antibiotic that acts on a wide range of pathogens and belongs to the group of aminoglycosides. At low concentrations, a bacteriostatic effect is manifested (inhibits the 30S ribosomal subunit and suspends protein synthesis); at high concentrations, a bactericidal effect is more pronounced (changes the permeability of cell membranes, causing cytolysis).

Antibacterial activity is high against: Staphylococcus spp. (including Staphylococcus epidermidis, Staphylococcus aureus and their penicillin-producing, coagulase-negative and coagulase-positive strains), Streptococcus spp. (including beta-hemolytic strains of group "A", some non-hemolytic strains, Streptococcus pneumoniae), Enterococcus spp., Escherichia coli, Proteus spp. (including Proteus vulgaris, Proteus mirabilis, indole-positive and indole-negative strains), Serratia spp., Enterobacter spp. (Enterobacter aerogenes), Providencia spp., Citrobacter spp., Haemophilus aegyptius, Morganella morganii, Acinetobacter calcoaceticus (Herellea vaginacola), Moraxella lacunata, some representatives of Neisseria spp. (including Neisseria gonorrhoeae).

Tobramycin is similar in spectrum of action to gentamicin, but the former is more active against gentamicin-resistant strains and can be used as a drug of choice when neomycin-containing eye drops are ineffective.

Tobramycin is highly effective against infections caused by Pseudomonas aeruginosa.

Tobramycin has low effectiveness against most strains of streptococci belonging to group D.

Pharmacodynamics and pharmacokinetics

Absorption into the systemic circulation is practically absent if the drug is applied topically.

Indications for use

Eye drops, like Tobrex eye ointment, are used to treat infectious and inflammatory lesions of the eye and surrounding tissues:

The use of Tobrex for barley (meibomitis) and the prevention of complications before and after ophthalmological interventions is also justified.

Contraindications

Individual hypersensitivity to the drug and its components.

Side effects of Tobrex

In 1.5% of cases, allergic reactions were detected, manifested by itching, lacrimation, and redness of the conjunctiva.

In 1% of cases, swelling and redness of the eyelids, swelling of the conjunctiva, and discomfort in the eye area were detected.

In less than 1% of cases, chemosis (swelling of the conjunctiva), blepharitis (inflammation of the edges of the eyelids), keratitis (inflammation of the cornea), eye pain, and isolated ulcerations were detected.

With long-term treatment, fungal superinfection may occur.

Instructions for use (Method and dosage)

The instructions for Tobrex eye drops and the instructions for Tobrex 2x eye drops differ in the frequency of administration of the drug: the first recommends instilling 1 drop 4-5 times a day, the second advises using 1 drop 2-3 times a day; Tobrex ointment is applied in a 1 cm column 2 times a day.

The difference between Tobrex and Tobrex 2x in the frequency of use is due to the thicker consistency of the latter drug. This feature allows the active substance to remain in the conjunctival sac longer and, therefore, reduce the frequency of drug administration without compromising the therapeutic effect. The course of treatment is 7-10 days.

In special cases, it is possible to practice instillation every hour, however, after the severity of symptoms has subsided, it is necessary to return to the above-mentioned regimen. At night, it is recommended to supplement treatment with Tobrex ointment to prolong contact with the drug.

Overdose

The characteristics of this drug do not suggest the appearance of any symptoms of poisoning when used correctly, or when the contents of one bottle are accidentally ingested.

Complaints in case of drug overdose may be similar to the side effects observed in some patients (pinpoint keratitis, increased lacrimation, redness, swelling and itching of the eyelids).

If an overdose of Tobrex does occur during topical use, it is recommended to rinse the eye with warm water.

Interaction

It is necessary to exclude the combined use of Tobrex with the following drugs:

Also, the simultaneous use of Tobrex with drugs containing tetracycline (due to the content of tyloxapol in the former) should not be allowed.

Terms of sale

In Russia, Tobrex is available without a prescription, in Ukraine only by prescription.

Storage conditions

Store out of the reach of children and away from light at a temperature of °C; an open bottle must be used within 30 days.

Best before date

3 years, provided the packaging is sealed.

special instructions

An unreasonable increase in the frequency of dosing and duration of use of the drug can lead to the appearance of microorganisms that are insensitive to the components of the drug, including fungal infections of the eye. If symptoms of superinfection appear, it is recommended to consult a doctor.

Analogues of Tobrex

Tobrex 2x, Tobrosopt and Tobrimed are complete analogues of Tobrex in release form and composition. From 51 to 34 hryvnia - this is the price in Ukraine for these analogues of eye drops, but in Russia it ranges from 126 to 221 rubles.

Tobrex for children

Instructions for children for taking Tobrex eye drops indicate that the drug can be used in pediatric practice in children aged 1 year and older in adult dosages. Studies confirm that the use of the drug is safe and effective in children, as well as newborns suffering from conjunctivitis, who were prescribed five times daily dosing of the drug for a week.

Tobrex for newborns

The instructions indicate that Tobrex can be used as eye drops for newborns strictly as prescribed by a doctor. When taken by newborns, the reviews are positive and there is no data indicating a side effect of the drug if the dosage and frequency of administration are observed.

With antibiotics

The interaction of Tobrex with other antibiotics is described above (see Interaction).

During pregnancy and lactation

The limited amount of data on the use of topical tobramycin in pregnant women does not allow conclusions to be drawn about the reproductive toxicity of the drug. It is recommended to refrain from using the drug during pregnancy.

There are no studies confirming that tobramycin passes into breast milk, but a risk to a breast-feeding baby cannot be ruled out. It is necessary to make a choice between the possibility of abstaining from breastfeeding during the period of treatment with Tobrex and refusing drug therapy, taking into account the positive effect of breastfeeding for the baby and of using the drug for a nursing mother.

Reviews for Tobrex

Numerous reviews of Tobrex eye drops indicate the speed of therapeutic action. Also, according to patients, these eye drops have an extremely small number of side effects or cases of lack of effect from therapy. There is evidence of the effective use of Tobrex as nasal drops for children suffering from rhinitis.

Price for Tobrex, where to buy

The Russian price of Tobrex eye drops, as well as the price of the ointment of the same name, does not differ from that in Ukraine. In general, the price of drops in Russia varies around rubles, the price of ointment is about 190 rubles; in Ukraine, the price tag for these drugs averages from 49 to 64 UAH.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Ukraine Ukraine
  • Online pharmacies in Kazakhstan Kazakhstan

WER.RU

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BIOSPHERE

Education: Graduated from Vitebsk State Medical University with a degree in Surgery. At the university he headed the Council of the Student Scientific Society. Advanced training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".

Work experience: Worked in a general medical network for 3 years as a surgeon (Vitebsk Emergency Hospital, Liozno Central District Hospital) and part-time as a district oncologist and traumatologist. Worked as a pharmaceutical representative for a year at the Rubicon company.

Presented 3 rationalization proposals on the topic “Optimization of antibiotic therapy depending on the species composition of microflora”, 2 works took prizes in the republican competition-review of student scientific works (categories 1 and 3).

Question: Can I use drops after replacing lenses?

Inna: Usually, insomnia occurs for me due to some kind of experience and when you lie down, it’s not.

Olesya: I tried glycine forte, which is more expensive in the price category, but the dosage is the same.

Andrey: Not a word is said about choosing the size of stockings according to a person’s parameters: height, leg size, etc.

Olga: For coxarthrosis of the 2nd degree, I have been injecting for 4 years at the rate (after 6 months), there is no improvement.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/tobreks

Tobrex - instructions for use, analogues, reviews, price

Tobrex eye drops

Release forms

  • Eye drops: 0.3% solution 5 ml in a sterile plastic dropper bottle.

1 ml of solution contains Tobramycin 3 mg and excipients.

  • Eye ointment 0.3%, 3.5 g in an aluminum tube.

    • Instructions for use of Tobrex eye drops

    Indications for use

    • Conjunctivitis (inflammation of the mucous membrane of the eye);
    • keratoconjunctivitis;
    • keratitis (inflammation of the cornea);
    • blepharoconjunctivitis;
    • blepharitis (inflammation of the edges of the eyelids);
    • dacryocystitis (inflammation of the lacrimal sac);
    • iridocyclitis (inflammation of the iris and ciliary body of the eyeball);
    • endophthalmitis (purulent inflammation of the inner membranes of the eyeball);
    • meibomitis (inflammation of the sebaceous glands of the eyelids).

    Tobrex is effective in treating these diseases if they are caused by bacteria sensitive to Tobramycin.

    Contraindications

    Side effects

    Treatment with Tobrex drops

    1. Wash your hands thoroughly with soap;

    2. Take a bottle with drops and shake several times;

    3. Open the bottle;

    4. Tilt your head back;

    5. Pull down the lower eyelid;

    6. Holding the bottle vertically and without touching the tip to the mucous membrane and eyelid, drop the medicine into the lower conjunctival sac, gently pressing the bottom of the bottle with your index finger;

    7. Release the lower eyelid and close the eye;

    8. Gently press your finger on the inner corner of the eye and hold for a couple of minutes;

    9. If you need to drip Tobrex into both eyes, then repeat the procedure for the second eye;

    10. Close the bottle.

    Adult patients are prescribed 1-2 drops every 4 hours into the lower conjunctival sac of the eye for 7-10 days.

    Tobrex for children

    Despite the fact that the instructions for the drug indicate that there has been insufficient research on the use of Tobrex in children under 1 year of age, the practical experience of pediatricians indicates the high effectiveness of Tobrex in newborns. Another positive thing is that the effect occurs quickly, without requiring long-term treatment.

    Tobrex for conjunctivitis

    Tobrex for barley

    Tobrex for a runny nose

    Analogues of Tobrex

    Brulamycin, Bramitob, Nembic, Dilaterob, Tobi, Tobracin, Tobrex 2X, Tobracin ADS, Tobropt.

    Levomycetin, Normax, Tsipromed, Oftaquix, Albucid, Floxal, Sulfacyl sodium.

    Reviews about the drug

    Drug price

    Read more:
    Reviews
    Leave feedback

    You can add your comments and feedback to this article, subject to the Discussion Rules.

    Source: http://www.tiensmed.ru/news/tobrex-ab1.html

    Tobrex eye drops for children and adults - instructions for use, price

    Tobrex eye drops are an effective antibacterial drug used in ophthalmology. Intended for the treatment of eye diseases in adults and children. This drug is used even in newborns, since it does not have a negative effect on the baby’s body. Tobrex is well tolerated by patients and causes virtually no side effects.

    Tobrex eye drops - description

    Photo: Tobrex drops

    Tobrex is a drug with a wide spectrum of antibacterial action. The active substance of the drug, tobramycin, belongs to the class of aminoglycosides and acts in two directions. In low concentrations it provides a bacteriostatic effect (disrupts protein synthesis in the cells of pathogenic microorganisms), in high concentrations it exhibits a bactericidal effect (destroys cytoplasmic membranes and causes the death of microbial cells).

    Tobramycin is active against a number of pathogenic microflora; the active substance has a detrimental effect on Proteus, Escherichia coli, staphylococci and streptococci, Klebsiella, gonococci, enterobacteria and other microorganisms.

    In terms of the spectrum of antimicrobial action, the drug is very similar to gentamicin, but exhibits higher activity against those strains of bacteria that are insensitive to this antibiotic. Therefore, Tobrex is often prescribed as a replacement when gentamicin-based drugs are ineffective. At the same time, tobramycin is insufficiently effective against strains of streptococci belonging to group D.

    Tobrex eye drops are intended for topical use, so the active substance is practically not absorbed into the bloodstream. This explains the safety of the drug, the minimum number of contraindications to its use and the absence of side effects.

    Composition, release forms

    Tobrex eye drops are a transparent, colorless, or slightly straw-colored, odorless solution. 1 ml of solution contains 3 mg of the active substance - tobramycin + auxiliary components (boric acid, sodium hydroxide, sodium sulfate, etc.). Drops are produced in convenient bottles - droppers with a volume of 5 ml, made of low-density polyethylene.

    In pharmacies, in addition to this form of the drug, you can find Tobrex 2X eye drops. The composition of these products, indications, contraindications and principles of action are generally identical. The only difference is that Tobrex 2X drops can be instilled less frequently (2-3 times a day). This is explained by the thicker consistency of the drug, which is provided by an auxiliary component such as xanth gum. This substance helps maintain the concentration of the active substance and allows it to remain in the conjunctival sac longer. Accordingly, the frequency of use of the drug is reduced without compromising the therapeutic result.

    When are Tobrex drops prescribed?

    Instructions for use of Tobrex indicate that eye drops are intended for the treatment of infectious and inflammatory lesions of the eyes and periorbital area. The main indications for use of the drug are the following conditions:

    1. conjunctivitis (inflammation of the mucous membrane of the eyes);
    2. blepharitis (inflammation of the eyelids);
    3. keratoconjunctivitis;
    4. blepharoconjunctivitis;
    5. keratitis (inflammation of the cornea of ​​the eyes);
    6. iridocyclitis (inflammation of the iris);
    7. endophthalmitis (purulent damage to the inner lining of the eyeball).

    It is advisable to use eye drops for meibomitis or, in other words, barley (purulent inflammation of the eyelids). Eye drops can be used not only for their intended purpose, but also used for instillation into the nose. This use of the drug is possible for sinusitis and sinusitis, when thick, purulent discharge forms in the nose. In this case, Tobrex drops help to avoid complications and quickly destroy pathogenic microorganisms.

    In addition, in ophthalmology, Tobrex drops are additionally used for prophylactic purposes in the postoperative period. Their use helps prevent the development of infectious complications.

    Contraindications

    In grateful reviews of Tobrex, patients say that the drug is very well tolerated and does not have a negative effect on the body. When applied topically, the active substance does not penetrate the bloodstream, and therefore systemic reactions from internal organs do not occur. Tobrex is one of the few drugs that has virtually no contraindications for use. The only limitation is individual intolerance to the components that make up the medication.

    Instructions for use

    Tobrex eye drops are intended for topical use. They are used according to the following scheme:

    • When treating uncomplicated infectious processes, the instructions for the drug recommend instilling 1-2 drops of solution into the conjunctival sac every 4 hours.
    • When treating acute manifestations of severe infections, the solution should be instilled every minute. The standard single dose is 2 drops in each eye. As the severity of inflammatory reactions decreases, the frequency of instillations should be gradually reduced, increasing the time intervals between procedures.

    The attending physician should prescribe the drug after clarifying the diagnosis and taking into account the severity of the symptoms of the ophthalmological disease.

    How to properly perform eye treatment?

    There is nothing complicated in using Tobrex drops, you just need to follow a certain procedure:

    • Before treating your eyes, wash your hands thoroughly with soap and water.
    • Remove the bottle of drops from the packaging and shake vigorously several times.
    • Open the bottle by removing the cap,
    • Tilt your head back and pull down your lower eyelid.
    • Turn the bottle over and hold it in an upright position, without touching the tip to the eyelids and mucous membranes of the eyes.
    • Lightly press the bottle with your fingers and gently drop 1-2 drops of the solution into the conjunctival sac.
    • Close your eyelids, lightly press your finger on the inner corner of your eye, and make several massaging movements.
    • Gently blot off excess solution with a cotton pad.

    Repeat the procedure for the other eye in the same order, then close and put away the bottle with the drug.

    If during the procedure you accidentally exceed the dose of the drug, there is nothing wrong with that. You need to rinse your eyes with warm water and repeat the treatment. After opening the bottle, the drug should be used within a month. The drops should be stored in a dark place at a temperature not exceeding 25 °C.

    Tobrex eye drops for children are used as prescribed by a doctor and in the recommended dosage. The standard treatment regimen for children over one year old involves using the solution five times a day. During each procedure, no more than 1 drop of solution should be instilled into the baby’s eyes. The course of treatment cannot exceed 7 days.

    Tobrex is highly effective in newborns. In pediatric practice, the drug is used to treat various inflammatory processes and infectious eye diseases in infants in the first months of life. The use of Tobrex helps to successfully fight conjunctivitis, inflammation in the lacrimal sac, blockage of the nasolacrimal duct and other abnormalities. Antibacterial drops can be used in infants for no more than 7 days.

    The drug Tobrex 2X is used for similar indications, but it is instilled less frequently - 1-2 drops 2-3 times a day. The optimal scheme for using the solution should be determined by the attending physician.

    Side effects

    Adverse reactions with the use of the drug rarely develop. They occur mainly in people with hypersensitivity and a tendency to allergic reactions and are manifested by lacrimation, redness and swelling of the conjunctiva, and itching. In this case, treatment with the drug is stopped and consultation with an ophthalmologist is sought to adjust subsequent treatment.

    In case of accidental overdose, symptoms such as profuse lacrimation, punctate keratitis, severe itching and swelling of the eyelids were noted. In isolated cases, patients complained of pain in the eyes and the appearance of small ulcers on the cornea. In case of overdose of the drug, it is recommended to rinse your eyes with warm water and consult a specialist. If necessary, the doctor will prescribe symptomatic treatment.

    Additional recommendations

    There is no clear opinion among experts about the possibility of using antibacterial drops during pregnancy and lactation. Doctors prescribe Tobrex drops for this category of patients only when the expected benefit from using the drug is higher than the potential risk of adverse reactions. The systemic effect of the active substance, tobramycin, in the drops is very insignificant, which means that the likelihood of a negative effect on the body of a pregnant woman and unborn child is minimal.

    Soft lenses should not be worn during treatment with Tobrex. If it is impossible to do without them, then before the procedure the lenses must be removed and then put on no earlier than 15 minutes after eye treatment.

    Remember that long-term use of antibacterial drops is unjustified; regular use of the drug for 24 days or more can lead to a decrease in its effectiveness and the appearance of pathogenic microorganisms that are insensitive to the action of the active substance. Therefore, in cases where the desired therapeutic effect cannot be achieved, it is recommended to do a laboratory test (culture) before and after treatment.

    Tobrex drops should not be prescribed simultaneously with antibiotics from the aminoglycoside group, since such a combination can lead to increased systemic side effects and provoke complications such as hearing loss, toxic effects on the kidneys, and disruption of hematopoietic processes.

    After the instillation procedure, blurred vision sometimes occurs, so it is not recommended to drive a vehicle or work on potentially dangerous equipment for half an hour.

    Analogs

    If necessary, Tobrex drops can be replaced with structural analogues containing the same active substance. The list of such drugs includes:

    If you are intolerant to tobramycin, your doctor may prescribe medications that contain a different active substance but provide an identical therapeutic effect. These are medications such as Albucid, Normax, Tsipromed, Levomycetin, Floxal. The selection of the necessary medication should be carried out by an ophthalmologist; you should not change the drug yourself, as this can lead to unpredictable consequences for eye health.

    In the pharmacy chain, the cost of the medicine varies depending on the form of release, the manufacturer and the pharmacists’ markup. On average, the price of Tobrex is about 200 rubles; Tobrex 2X eye drops are slightly cheaper - from 170 rubles per pack.

    Reviews about the use of Tobrex are overwhelmingly positive. Patients note a good therapeutic effect even after a short course of using antibacterial drops. The drug quickly stops the inflammatory process, eliminates unpleasant symptoms (itching, irritation, lacrimation, swelling) and speeds up recovery.

    The use of the drug in pediatric practice deserves special mention. The main advantage of Tobrex is safety and the absence of side effects. This allows it to be used to treat newborns and infants and achieve a lasting therapeutic effect in various ophthalmological pathologies.

    Reviews about the application

    Tobrex eye drops are very good for conjunctivitis. I often encounter this problem. Previously, I was treated with Albucid, but when using it, my eyes began to sting severely. The doctor advised me to try these drops, I bought the drug and I really liked its effect. Tobrex relieves all symptoms of conjunctivitis very quickly, without any discomfort. After instillation, the eyes do not burn; on the contrary, relief immediately sets in, itching, irritation, redness go away, and lacrimation stops. Usually, five days of using the drug is enough for me to cope with conjunctivitis and eliminate unpleasant symptoms.

    Review #2

    Recently my daughter came home from kindergarten with red eyes; they thought she had rubbed it or got dust. They washed her eyes, but the baby continued to rub them with her hands. The next morning she could barely open her eyelids, purulent discharge appeared, her eyes were swollen and red. At an appointment with an ophthalmologist, it turned out that it was conjunctivitis. The doctor prescribed Tobrex 2X drops for us and said that this is a strong drug and we only need to drip it 2-3 times a day. The medicine is quite inexpensive, there are also simple Tobrex drops, but the pharmacist explained that they need to be instilled more often, almost every hour. It took us only three days to eliminate all the symptoms. Tobrex is a very strong remedy and, most importantly, safe, since the treatment went smoothly and there were no side effects.

    Review #3

    I suffer from hay fever and every year when certain plants bloom, I suffer from allergy symptoms. Along with a runny nose, sneezing, and headache, signs of allergic conjunctivitis appear: the eyes become red, swollen, itchy, and tears flow constantly. I take certain antihistamines and also put Tobrex in my eyes. This is a very good drug that quickly relieves all inflammatory manifestations. In the first days you can use it every hour, and then less often. But usually a week of treatment is enough for everything to return to normal.

    Review #4

    My child was prescribed Tobrex eye drops while still in the maternity hospital. The baby had some kind of inflammatory process in the lacrimal canal. The medicine was instilled into the eyes twice a day. In the first days, my son’s tears flowed constantly, but after 2 days everything stopped. We used this medicine for about 5 days in total. I was worried, but the pediatrician explained that it would not do any harm. The active substance of Tobrex does not penetrate the blood, it acts only at the local level, so it cannot harm the baby in any way.

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    Before using medications, consult your doctor!

    Source: http://glavvrach.com/glaznye-kapli-tobreks/

    Tobrex eye drops: instructions for use

    Tobrex eye drops belong to drugs of the pharmacological group antibiotics for local use. They are used in ophthalmology for etiotropic therapy (treatment aimed at eliminating the impact of the cause of the disease) of infectious pathology of eye structures.

    Description of the dosage form, composition

    Tobrex eye drops are a colorless transparent solution. They contain tobramycin as the main active ingredient, its concentration in 1 ml of solution is 3 mg (0.3% solution of eye drops). The solution also contains auxiliary components, which include:

    • Boric acid.
    • Benzoalkonium hydrochloride.
    • Tiloxapol.
    • Sodium sulfate.
    • Sodium hydroxide.
    • Purified water.

    The solution of Tobrex eye drops is contained in a plastic dropper bottle with a volume of 5 ml. The cardboard pack contains 1 bottle of drops and instructions for use of the drug.

    Therapeutic effects, pharmacokinetics

    Tobramycin, which is the main active component of Tobrex eye drops, is an antibiotic of the aminoglycoside group. It has a wide spectrum of activity against a significant number of different types of pathogenic (pathogenic) and opportunistic bacteria, including gram-positive streptococci, staphylococci, gram-negative moraxella, enteropathogenic Escherichia coli, Klebsiella, Proteus, Pseudomonas aeruginosa, Haemophilus influenzae. The antibacterial effect of the antibiotic is realized by disrupting the functional activity of ribosomes in bacterial cells (blockade of the 30S subunit) and reducing the activity of the protein synthesis process.

    After local use of Tobrex eye drops, systemic absorption of the active substance is minimal.

    Indications for use

    The use of Tobrex eye drops is indicated for various infectious and inflammatory pathologies of the eyes and their appendages caused by bacteria sensitive to tobramycin:

    • Blepharitis is inflammation of the conjunctiva.
    • Keratitis is a lesion of the cornea.
    • Conjunctivitis is inflammation of the conjunctiva of the eyes.
    • Keratoconjunctivitis is a combined lesion of the conjunctiva and cornea.
    • Iridocyclitis is an inflammation of the iris and ciliary body of the eye.

    The drug is also used to prevent various postoperative complications in ophthalmology associated with secondary bacterial infection and the development of inflammation.

    Contraindications for use

    The only absolute medical contraindication for the use of Tobrex eye drops is individual intolerance to any of the components of this medicine. Before starting to use this medication, it is important to exclude the presence of contraindications.

    Directions for use, dosage

    Tobrex eye drops are intended for local external use. Using a dropper bottle, they are instilled into the conjunctival sac of the eye affected by the infectious process. For mild inflammation and a pathological process of moderate severity, the drug is used 1-2 drops, which are instilled every 4 hours. In case of severe infection, the solution is instilled every minute; as the manifestations of inflammation decrease, the frequency of instillation is reduced.

    Negative reactions

    In general, Tobrex eye drops are well tolerated. Sometimes, against the background of their use, it is possible to develop local allergic reactions in the form of redness of the conjunctiva, swelling of the eyelids. In this case, you should stop using the drug and consult a medical specialist.

    Features of use

    Before you start using Tobrex eye drops, you should carefully read the instructions for the drug. There are several features of the correct use of the drug, which include:

    • Long-term use of the drug may lead to increased growth of bacteria that are resistant to tobramycin.
    • During the course of treatment with the drug, the use of contact lenses is not allowed.
    • There is currently no sufficient data regarding the safety of the drug for children and pregnant women, so use is only possible for strict medical indications, if the expected benefits significantly outweigh the potential risks.
    • The drug does not have a direct effect on the functional state of the nervous system. Due to the fact that visual acuity may decrease immediately after instillation of the solution, it is not recommended to perform work that requires sufficient visual acuity during this period of time.

    The pharmacy chain sells Tobrex eye drops without a prescription. If you have any doubts regarding the use of the drug, you should consult a medical specialist.

    Exceeding the dosage

    In case of excessive instillation of Tobrex solution, a burning sensation, swelling of the eyelids, and redness of the conjunctiva may occur. In this case, symptomatic therapy is carried out.

    Proper storage

    The shelf life of Tobrex eye drops is 3 years. The drug should be stored in its original original packaging, in a dark, dry place, out of reach of children, at an air temperature of +8 to +30 ° C. After opening the bottle, the solution should be used for a period of no more than 1 month.

    Analogs of Tobrex eye drops

    Structural analogues of Tobrex eye drops based on the active substance are: Brulamycin, Bramitob, Nembits, Dilaterob, Tobi, Tobracin, Tobracin ADS, Tobropt.

    Analogs for therapeutic action are: Levomycetin, Normax, Tsipromed, Oftaquix, Albucid, Floxal, Sulfacyl sodium.

    Tobrex eye drops price

    The average cost of Tobrex eye drops in Moscow pharmacies varies within rubles.

    Source: http://bezboleznej.ru/tobreks-glaznyye-kapli

    Tobrex: instructions for use

    Compound

    Tobramycin - 3 mg.

    Benzalkonium chloride, boric acid, sodium sulfate anhydrous, sodium chloride, tilaxopol, sulfuric acid and/or sodium hydroxide qs to adjust pH, purified water.

    Description

    pharmachologic effect

    Highly active against the following susceptible strains:

    — Staphylococcus spp., including Staphylococcus aureus and Staphylococcus epidermidis (coagulase-negative and coagulase-positive), including strains resistant to penicillin.

    - Streptococcus spp., including some groups - a-p-hemolytic species, some non-hemolytic species and Streptococcus pneumoniae.

    — Pseudomonas Aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis (indole-negative) and indole-positive species of Proteus, Haemophilus influenzae and H.aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus (Herellea vaginacola) and some species of Neisseria (including including Neisseria gonorrhoeae).

    Pharmacokinetics

    Indications for use

    Prevention of postoperative infectious complications in ophthalmology.

    Contraindications

    Pregnancy and lactation

    Clinical studies have shown that tobramycin is safe and effective for use in children.

    Directions for use and doses

    How to instill the drug correctly.

    • Wash your hands thoroughly before instillation.

    • Tilt your head back. Pull your lower eyelid down and look up. Place 1¬2 drops into the space between the eyelid and the eyeball. Do not touch the tip of the bottle to your eyelids, eyelashes, or touch it with your hands.

    • Close your eye and pat it dry with a cotton swab.

    • Without opening your eyes, lightly press the inner corner of your eyes for 2 minutes. This will improve the effectiveness of the drops.

    • The bottle must be tightly closed after each use.

    Side effect

    an allergic reaction accompanied by itching and swelling of the eyelids, as well as conjunctival hyperemia.

    Overdose

    Interaction with other drugs

    Features of application

    Wearing contact lenses during treatment with the drug is unacceptable.

    Patients who temporarily lose clarity of vision after instillation of the drug are not recommended to drive a car or work with complex machinery, machines or any other complex equipment that requires clarity of vision.

    Release form

    Storage conditions

    Best before date

    Conditions for dispensing from pharmacies

    You should consult your doctor and read the instructions before use.

    Source: http://apteka.103.by/tobreks-instruktsiya/

    Tobrex - official instructions for use

    on medical use of the drug

    Registration number:

    International nonproprietary name:

    Dosage form:

    Composition of eye drops (per 1 ml):

    Active substance: tobramycin 3.00 mg;

    Excipients: benzalkonium chloride, solution, equivalent to benzalkonium chloride 0.10 mg; boric acid 12.40 mg; sodium sulfate anhydrous 1.52 mg; sodium chloride 2.78 mg; tyloxapol 1.00 mg; sulfuric acid and/or sodium hydroxide to adjust pH; purified water to 1 ml.

    Composition of eye ointment (per 1 g):

    Active substance: tobramycin 3.0 mg;

    Excipients: anhydrous chlorobutanol 5.0 mg; liquid paraffin (syn. mineral oil) 50.0 mg; white petroleum jelly up to 1 g.

    Eye drops: transparent solution from colorless to light yellow.

    Eye ointment: a homogeneous ointment of white or almost white color.

    Pharmacotherapeutic group:

    pharmachologic effect

    Broad-spectrum antibiotic from the aminoglycoside group. It has a bactericidal effect, disrupting protein synthesis and the permeability of the cytoplasmic membrane of the microbial cell.

    Active against the following susceptible microorganisms:

    — Staphylococci, including S.aureus and S.epidermidis (coagulase-negative and coagulase-positive), including strains resistant to penicillin.

    — Streptococci, including some β-hemolytic strains of group A, non-hemolytic species and Streptococcus pneumoniae.

    — Pseudomonas Aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis (indole-negative) and indole-positive Proteus species, Haemophilus influenzae and H.aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus (Herellea vaginacola) and some Neisseria species.

    When applied topically, systemic absorption is low.

    Indications for use

    Infections of the eye and its appendages:

    Prevention of postoperative infections.

    Contraindications

    Individual hypersensitivity to the components of the drug.

    Use during pregnancy and lactation

    There is no sufficient experience with the use of the drug during pregnancy and breastfeeding. It can be used for the treatment of pregnant and nursing mothers as prescribed by the attending physician, if the expected therapeutic effect exceeds the risk of developing possible side effects.

    There is no sufficient experience with the use of the drug in childhood. It is possible to use the drug as prescribed by the attending physician if the expected therapeutic effect exceeds the risk of developing possible side effects.

    Directions for use and doses

    For mild infections, 1-2 drops into the conjunctival sac every 4 hours.

    In case of acute severe infectious process, 2 drops into the conjunctival sac every 60 minutes, with a decrease in the frequency of drug instillations as inflammation decreases.

    For a mild infection, apply a strip of ointment about 1.5 cm into the conjunctival sac 2-3 times a day.

    In case of acute severe infectious process, a strip of ointment about 1.5 cm into the conjunctival sac every 3-4 hours, with a decrease in the frequency of use of the drug as the inflammation decreases.

    It is possible to combine the use of ointment and eye drops.

    Side effects

    Local. An allergic reaction, accompanied by itching and swelling of the eyelids, conjunctival hyperemia, and lacrimation. There may be a burning sensation and a sensation of a foreign body in the eye.

    Overdose

    Symptoms: punctate keratitis, erythema, increased lacrimation, itching and swelling of the eyelid.

    Interaction with other drugs

    In the case of simultaneous administration of tobramycin topically with systemic aminoglycoside antibiotics, systemic side effects may be increased.

    special instructions

    Long-term use of an antibiotic can lead to excessive growth of non-susceptible microorganisms, including fungi. In case of superinfection, adequate therapy must be prescribed.

    Patients using contact lenses should remove the lenses before using the drug and put them back no earlier than 15 minutes after instillation of the drug.

    Patients whose vision clarity is temporarily reduced after using the drug are not recommended to engage in activities that require increased attention and reaction until it is restored.

    The bottle must be closed after each use.

    Release form

    Eye drops 0.3%:

    5 ml in a Droptainer™ dropper bottle made of low-density polyethylene. 1 bottle with instructions for use in a cardboard pack.

    Eye ointment 0.3%:

    3.5 g in an aluminum tube with a plastic screw cap. 1 tube with instructions for use per cardboard box.

    Shelf life

    Do not use after the expiration date indicated on the package.

    Eye drops should be used within 4 weeks after opening the bottle.

    Storage conditions

    List B. At a temperature of 8-30°C, out of the reach of children.

    Vacation conditions:

    Manufacturer:

    "s.a. Alkon-Couvreur n.v., B-2870 Puurs, Belgium.

    Address of the representative office of Alcon Pharmaceuticals Ltd. and acceptance of claims:

    Source: http://medi.ru/instrukciya/tobreks_8190/

    Tobrex eye drops: instructions for use for newborns and children over one year old, analogues of the drug

    Inflammatory eye diseases in children are quite common. If we are talking about infants, then the list of drugs that can be used to treat a particular condition is reduced. Eye diseases caused by bacteria respond well to treatment with special drops, such as Tobrex. We will look at how to use this drug, what its features are and whether there are any contraindications in this article.

    Active ingredient and principle of operation

    Tobrex drops are an antibiotic, that is, they inhibit the vital activity of certain types of bacteria. The active ingredient of the drug, Tobramycin, belongs to the group of aminoglycosides. Despite the fact that this antibiotic has a broad spectrum of action, it works most effectively against the following types of bacteria that cause ophthalmic diseases:

    Tobramycin may not cope with other types of microorganisms. The instructions indicate that treatment with the drug will not bring results if the disease is caused by anaerobic bacteria or chlamydia. Enterococcus responds to treatment with Tobrex very mediocre.

    This local antibiotic is well and completely excreted in the urine without changes. The manufacturer notes that the effect of Tobramycin on the body is negligible. In addition, the dosage of the active substance in the drug is gentle - only 3%. Thanks to the listed properties, Tobrex is indicated for use in children from birth. The doctor must only determine the required duration of treatment.

    Release form

    Tobrex is available in the form of drops, as well as an ointment - it should be white or cream in color. The ointment is applied to the inner surface of the eyelid in the form of a strip. Due to its thick texture, the drug retains its bactericidal effect longer, however, this form is used mainly for adults. A combination of ointment and drops is possible.

    Tobrex drops are produced in plastic dropper bottles with a volume of 5 ml. This amount of solution is quite enough for a course of treatment. The solution is transparent and may have a slightly yellowish tint. In addition to tobramycin, the solution contains excipients: boric acid, sodium sulfate, sodium hydroxide, etc.

    Tobrex 2X drops are also on sale. This drug is almost the same in composition as its analogue, but has a thicker consistency. This is due to the presence of xanth gum among the ingredients of the drug. Thanks to this component, the medication stays in the conjunctival sac longer and has time to work more effectively. In this case, the dose of Tobrex 2X drops should be reduced by 2 times compared to regular Tobrex.

    Indications for use

    Treatment of ophthalmological diseases in children under one year of age should be supervised by a doctor. Tobrex for children is prescribed if the child is diagnosed with:

    • dacryocystitis is a common disorder in newborns caused by blockage of the lacrimal canal;
    • endophthalmitis – when the membranes inside the eyeball become inflamed;
    • inflammation of the cornea of ​​the eye, called keratitis, as well as keratoconjunctivitis;
    • disease of the area of ​​the eyelid where eyelashes grow - blepharitis;
    • barley is a well-known disease of the follicle or sebaceous gland, which manifests itself in the form of a purulent, inflamed “grain”;
    • conjunctivitis is an inflammation of the upper layer of the eye - the conjunctiva, which is manifested by redness of the white, as well as purulent discharge.

    These drops are also indicated for use after ophthalmological operations. In this case, their task is to prevent inflammation from occurring in the operated area.

    Tobrex is not prescribed for viral ophthalmic infections. However, bacterial, viral or allergic conjunctivitis, in the eyes of the average person, differs little. In this regard, a doctor must make a diagnosis and prescribe treatment as well. Moreover, many pediatricians insist on conducting laboratory tests that show how sensitive the pathogen is to a certain group of antibiotics. This procedure is relevant for newborns, since such babies are treated with a very limited range of drugs. Similar analysis:
    • will allow the doctor to prescribe effective therapy;
    • will make it possible to avoid taking medications that will not bring benefit;
    • will eliminate the possibility of microorganisms becoming resistant to antibiotics.

    Instructions for use

    The instructions for the drug indicate that Tobrex should not be used for more than 7 days. Otherwise, there is a risk of superinfection, which is much more difficult to cure. Superinfection occurs quite often during antibiotic treatment. In different cases, the doctor prescribes a different treatment regimen. How many drops can a baby give?

    To treat conjunctivitis, the drug should be instilled 1-2 drops into each eye, slightly moving the lower eyelid. If the inflammatory process is uncomplicated, you need to instill 2 drops into each eye, once every four hours. In the acute phase of the disease, it is recommended to instill eye drops more often - once an hour.

    When treating infants, you must strictly adhere to the instructions given by the doctor.

    During the treatment of barley, usually the treatment regimen is designed so that the intensity of the effect of the antibiotic gradually decreases. For example, the first two days the eye should be instilled 5 times a day, then 4 times, 3 – and so on until the barley is ripe. However, in each specific case, the doctor may suggest a different treatment plan, depending on the age of the child and the intensity of the inflammatory process.

    How to put eye drops correctly?

    Despite the fact that the eye drop procedure is simple, it should be performed according to the rules. The sequence of actions should be like this:

    • First you need to wash your hands;
    • Shake the bottle with the drug;
    • put the baby on his back;
    • pull down the lower eyelid;
    • turn the bottle upside down;
    • apply eye drops without touching the tip to the mucous membrane;
    • close your eyes, then lightly massage your eyelid and blot off any excess medication with a napkin.

    After use, the bottle should be closed and stored out of reach of the baby. The drug is suitable for use within 30 days after opening.

    Side effects

    The drug may have side effects, but they are rare. There are cases where patients complained of swelling of the eyelids and excessive lacrimation after using drops. Very rarely, situations arise when a patient develops multiple ulcers on the surface of the eyeball. All such manifestations are caused by individual intolerance to one or more components of the solution or allergies.

    Tobrex for runny nose

    Sometimes pediatricians recommend putting eye drops into the nose. This is due to the fact that these drugs dry out the mucous membrane that lines the nasal passages. Most often, Tobrex (or analogues) is prescribed if a child has green snot and a runny nose that does not go away for more than 7 days. As a rule, sinusitis, sinusitis, and sinusitis are treated in this way. This rhinitis is bacterial in nature, and topical antibiotics are ideal to combat it.

    However, to achieve maximum effect, before instilling Tobrex into your nose, you should rinse your nasal passages with saline solution. Then clear the nose of mucus using an aspirator if the baby cannot blow his nose on his own.

    Analogues of the drug

    Tobrex is a fairly effective drug, but other drugs are also used to treat newborns and older children. Let's look at analogues of the drug, which ones are cheaper, as well as their features.

    Tobrex has several analogues, among which you can choose the appropriate treatment option

    There are also almost complete analogues of Tobrex, the active substance of which is identical. These include Brulamycin, Nebcin, Tobi, Dilaterol.

    Washing your eyes with home remedies has a good effect. To do this, you need to moisten a cotton pad in the prepared broth and rinse the eye, starting from the outer corner to the inner. You can use:

    • Black tea;
    • green tea (without additives or flavorings);
    • camomile tea;
    • furatsilin (dissolve 1 tablet in ½ cup of boiled water).

    If a child's eye turns sour, you should definitely show it to the pediatrician. Perhaps the problem will be solved quickly if treatment is started immediately. However, you should not prescribe any drops to your child yourself, especially if it is an infant.

    We cured stye with Tobrex. Our daughter somehow woke up with a reddened eyelid. At first we didn’t pay attention, but the redness increased every day. We took her to the ophthalmologist - it turned out it was stye. As soon as they started dripping Tobrex, the grain ripened, then it burst. So , works.

    Attention! All information on the site is provided for informational purposes only and is for informational purposes only. For all questions regarding the diagnosis and treatment of diseases, you must consult a doctor for an in-person consultation.

    Source: http://vseprorebenka.ru/zdorove/preparaty/tobreks-glaznye-kapli-instrukciya-dlya-detej.html