Calcium gluconate tablets instructions

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Calcium gluconate tablets: application

Calcium gluconate tablets are a drug belonging to the pharmacotherapeutic group for the regulation of calcium-phosphorus metabolism. Calcium gluconate is used to normalize the balance of tissue metabolism, or more precisely, to neutralize the lack of calcium in the body.

Table of contents:

The drug, which can be freely purchased without a prescription, is available as white tablets without a characteristic odor or taste, and also in the form of a solution for intravenous and intramuscular injections. One calcium gluconate tablet contains 0.5 grams of the active component - calcium gluconate monohydrate - and excipients such as starch, talc, calcium stearate monohydrate. 1 milliliter of solution contains 0.1 grams of the active substance.

Calcium not only plays perhaps the most important role in the development of bone tissue, and subsequently ensuring the strength of the entire human skeletal system, but also its use promotes blood clotting, strengthens tooth enamel, affects the conduction of nerve impulses, maintains the normal functioning of the heart muscle and takes active participation in the metabolism of the whole organism. In addition, calcium reduces the permeability of blood vessels, and when administered intravenously, it increases the production of adrenaline and causes general stimulation of the nervous system.

Indications for use

The instructions included with each package of the drug, which can be purchased at every pharmacy, indicate the following indications for the use of calcium gluconate, both in tablets and in solution:

  • Increased need of the body for calcium (period of active development of the body, period of bearing a child, period of breastfeeding), metabolic disorders of the element during postmenopause, insufficient presence of calcium in food;
  • A number of diseases, the symptoms of which are increased vascular permeability, hypocalcemia, disruption of the movement of nerve signals;
  • Bleeding of various origins;
  • Inflammatory processes occurring in the pelvic organs;
  • Increased leaching of calcium from body cells due to chronic diarrhea, prolonged use of diuretics and some antiepileptic drugs, long periods of immobility);
  • Rickets;
  • Allergic diseases (urticaria, itching, dermatosis, serum sickness, allergies to certain foods and medications, angioedema);
  • Asthma, pulmonary tuberculosis, chronic bronchitis, lead colic, nutritional edema;
  • Poisoning with certain acids, magnesium salts;
  • Various dermatoses accompanied by weeping eczema
  • Vitamin D metabolism disorders;
  • Osteoporosis;
  • Inflammation of the urinary tract;
  • Liver diseases, hepatitis, nephritis, paroxysmal myoplegia.

Contraindications

  • The use of calcium supplements is not recommended in such cases.
  • Hypersensitivity to some components of the drug.
  • Hypercalcemia.
  • Sarcoidosis.
  • Tendency to thrombosis.
  • Concurrent administration of cardiac glycosides.

Taking into account all the indications, both tablets and calcium gluconate solution can be taken with caution in cases of moderate renal failure, diarrhea, heart failure, and atherosclerosis. For children of different ages, doctors recommend the use of intramuscular injections of calcium gluconate only in special cases.

Side effects

When using the medication calcium gluconate, as the instructions indicate, the following side effects may occur:

  • When taking the medicine in tablets orally - hypercalcemia, stomach irritation;
  • When a solution is administered orally - vomiting, diarrhea, nausea, bradycardia;
  • With intravenous administration - a feeling of internal heat throughout the body, fainting, decreased blood pressure, cardiac arrest is possible;
  • With rapid intramuscular administration, tissue necrosis at the injection site is possible.

Dosage and rules of use

The instructions for treatment with calcium gluconate describe in detail the doses and methods of taking it. Calcium gluconate tablets can be taken orally by both adults and children of all ages. The drug must be crushed before use.

Adults can take calcium gluconate tablets, usually 1 to 3 grams. (maximum 9 grams per day) 2 – 3 doses per day. Pregnant women and nursing mothers can take the drug only following the regimen prescribed by the attending physician.

  • children under 1 year of age can take the drug, previously crushed and dissolved in a small amount of milk or formula, not more than 0.5 g;
  • children aged 2–4 years can drink 1 gram. (maximum – 3);
  • children aged 5 - 6 years - from 1 to 1.5 g. (maximum dose 4.5 g per day) depending on the disease;
  • children from 7 to 9 years old – 1.5 – 2 g. (no more than 6 grams during the day);
  • Teenagers 10 - 14 years old can drink an average of 2 - 3 grams of the product. (but, like adults, no more than 9 grams per day).

The medication tablets should be taken 2-3 times a day before meals or an hour and a half after meals, always with a glass of milk or boiled water to avoid possible salt deposits in the kidneys. If you have calcium deficiency, it is better to take tablets in the evening. As the instructions indicate, when carrying out a course of treatment with calcium gluconate, an adult needs to drink about 2 liters of water per day.

Intravenously and intramuscularly, a solution of calcium gluconate is infused dropwise or at low speed, over a period of 2 to 3 minutes. Before injection, the solution must be warmed to body temperature. It is important that the calcium gluconate does not precipitate; not the slightest trace of ethanol should remain in the syringe. In case of pronounced allergic reactions, a 10% solution of calcium gluconate is used as an “ambulance”. It is very important that intravenous injection of calcium gluconate should be carried out exclusively by a medical professional, since if the medicine gets into adjacent soft tissues, it may provoke their necrosis.

For adults, the injection dose is from 5 to 10 milliliters of a 10 percent solution, depending on the diagnosis, every day, every other day or every two days.

Children are also given a 10% solution of calcium gluconate, warmed to body temperature, at a very low rate, depending on their age - from 1 to 5 milliliters of a 10% solution, keeping an interval of 2 days.

Quite often, the drug calcium gluconate is prescribed by a doctor for colds, both for oral administration and in the form of a “hot injection”, since this drug has the ability to protect blood vessels from deformation, reducing their fragility during inflammation, and reduce general intoxication of the body.

Analogues of the drug

Today, you can buy many different drugs similar to calcium gluconate in pharmacies. The most popular tablets of them are Calcium D3 Nycomed, Elevit, Calcium S, Calcinova, Multitabs, Vitrum, Calcium-Sandoz, Vitacalcin. In addition to calcium itself, these analogue products contain various components that promote more complete absorption of this microelement, for example ascorbic acid, as well as anti-inflammatory and antiviral complexes. But for all these pharmaceuticals, the instructions as the main indication indicate a lack of calcium in the body, as a result of which disturbances in the formation of the skeletal system and teeth occur.

Also in the pharmacy you can buy calcium gluconate substitutes such as Calcium gluconate tablets Vial, stabilized, Calcium gluconate with various fruit flavors, calcium gluconate Darnitsa. You just need to remember that, if there are such indications, you can take these and similar calcium gluconate substitutes only in consultation with your doctor.

Release from the pharmacy and storage conditions

Calcium gluconate should be stored in a dry place, out of reach of children. The temperature at which the medicine can be stored should not rise above 25 degrees. The shelf life of this drug is 5 years. Do not use after the date printed on the blister or carton. Since calcium gluconate is an over-the-counter product, you can buy it freely.

Calcium gluconate

Description current as of 03/14/2016

  • Latin name: Calcium gluconate
  • ATX code: A12AA03
  • Active ingredient: Calcium gluconate
  • Manufacturer: Moskhimfarmpreparaty im. N.A. Semashko, Eskom NPK OJSC, Dalkhimfarm, Armavir biofactory, Binnopharm CJSC, Veropharm OJSC, Ellara LLC, Medisorb (Russia)

Compound

One tablet may contain 250 or 500 mg of active substance.

Auxiliary components: potato starch, anhydrous silicon dioxide in colloidal form, calcium stearate.

The concentration of the active substance in 1 ml of solution is 95.5 mg. 1 ml of the drug contains 8.95 mg of total calcium (Ca2+), which in terms of the theoretical content of calcium gluconate is 100 mg/ml. The solution contains calcium sucrose and water as auxiliary components.

Release form

  • tablets 10 pcs. in cell-free contour packages, 1, 2 or 10 packages in a cardboard box;
  • chewable tablets 10 pcs. in cell-free contour packages, 1, 2 or 10 packages in a cardboard box;
  • solution for intravenous and intramuscular administration. Ampoules 1, 2, 3, 5 and 10 ml, package No. 10.

pharmachologic effect

The drug helps restore calcium deficiency, has antiallergic, hemostatic, detoxification, and anti-inflammatory effects.

Takes part in the transmission of nerve impulses, blood clotting, contraction of smooth and skeletal muscles and a number of other physiological processes.

Pharmacodynamics and pharmacokinetics

Calcium gluconate - what is it?

Calcium gluconate is a mineral supplement that is used to treat conditions caused by calcium deficiency in the body. The calcium content in the preparation is 9%. The INN (Calcium gluconate) was assigned to the active substance based on data from the European Pharmacopoeia (Ph.Eur.).

Ca ions are involved in the transmission of nerve impulses; without them, the myocardium cannot function normally, contraction of smooth and skeletal muscles, and blood clotting processes; Without them, bone tissue cannot form normally, and other organs and systems cannot function.

The gross formula of calcium gluconate is C12H22CaO14.

Pharmacodynamics

In many diseases, the concentration of Ca ions in the blood decreases; at the same time, severe calcium deficiency contributes to the development of tetany. The drug not only prevents the occurrence of hypocalcemia, but also reduces the permeability of vascular walls, relieves inflammation, has an antiallergic and hemostatic effect, and reduces exudation.

Ca ions are a plastic material for teeth and skeleton; many enzymatic processes occur with their participation; they are responsible for regulating the permeability of cell membranes and the speed of transmission of nerve impulses.

They are needed for the process of neuromuscular transmission and maintaining the contractile function of the heart muscle. If we compare calcium gluconate with calcium chloride, the latter has a more pronounced local irritating effect.

Pharmacokinetics

When taken orally, the substance is partially absorbed, mainly in the small intestine. TCmax - 1.2-1.3 hours. T1/2 of ionized Ca from blood plasma - from 6.8 to 7.2 hours. Penetrates into breast milk and through the placental barrier. It is excreted from the body mainly by the kidneys, but also with the contents of the intestines.

Indications for use of Calcium gluconate

What is Calcium Gluconate tablets for?

Tablets are recommended for conditions accompanied by hypocalcemia, increased permeability of cell membranes, and disturbances in the conduction of nerve impulses in muscle tissue.

Doctors answer the question “what is calcium gluconate used for?” answer that the use of the drug is advisable for:

  • hypoparathyroidism (osteoporosis, latent tetany);
  • disorders of vitamin D metabolism (spasmophilia, rickets, osteomalacia);
  • hyperphosphatemia in patients with chronic renal failure;
  • increased need for calcium (pregnancy, breastfeeding, periods of intensive growth in children/adolescents);
  • insufficient Ca content in the diet;
  • bone fractures;
  • Ca metabolism disorders in the postmenopausal period;
  • conditions that are accompanied by increased calcium excretion (chronic diarrhea, prolonged bed rest; long-term treatment with diuretics, corticosteroids or antiepileptic drugs);
  • poisoning with oxalic acid, Mg salts, soluble salts of fluoric acid (the advisability of using the product as an antidote is due to the fact that, interacting with these substances, Ca gluconate forms non-toxic Ca oxalate and Ca fluoride).

Why are calcium gluconate injections used?

Calcium gluconate in ampoules is prescribed for certain pathologies of the parathyroid glands, conditions that are accompanied by increased excretion of Ca from the body, as an adjuvant for allergies, as well as for allergic complications of treatment with other drugs, to reduce vascular permeability in various types of pathological processes, for nephritis, eclampsia, liver intoxication, hyperkalemia, parenchymal hepatitis, hyperkalemic form of periodic paralysis (paroxysmal myoplegia), as a hemostatic agent.

Indications (intravenously/intramuscularly) for administration of the drug are also poisoning with soluble salts of fluoric acid, oxalic acid or Mg salts, for skin diseases (psoriasis, itching, eczema).

In some cases, Calcium gluconate is used during autohemotherapy. This method of treatment has proven itself well for skin diseases, furunculosis, recurrent colds, diabetes, rheumatism, allergies, and during the recovery period after serious illnesses.

10 ml of calcium gluconate solution is injected into the patient's vein, and then blood is immediately taken from the vein and transferred back in the form of a subcutaneous injection or injection into the gluteal muscle.

What is a hot shot?

Injections of the drug are also known as “hot injections of calcium gluconate.” In fact, the solution is administered heated only to body temperature.

A hot injection is called a hot injection because of the subjective sensations that arise in the patient: after the injection, there is usually a feeling of warmth spreading throughout the body, and sometimes a fairly strong burning sensation.

Calcium gluconate for allergies

Doctors have proven that one of the causes of allergies may be a severe calcium deficiency in the body. It is with Ca deficiency that most allergic reactions in children are associated: the child’s body grows very rapidly, and as a result, the Ca content in all its tissues decreases.

In addition, factors that contribute to the formation of Ca deficiency are excess vitamin D in the body and teething.

For this reason, calcium gluconate is often used as one of the methods for preventing and treating allergies in patients predisposed to this condition.

With sufficient calcium intake into the body, the permeability of the vascular walls decreases, and the penetration of allergens into the systemic bloodstream becomes more difficult. This means that an increase in Ca concentration is accompanied by a decrease in the likelihood of an acute immune reaction.

Calcium gluconate is used in combination with antihistamines. The drug is prescribed, among other things, to eliminate side effects caused by taking other medications.

Studies have shown that, as a source of calcium alone for the body, the calcium salt of gluconic acid is the least active, however, calcium gluconate is best suited for the treatment and prevention of any allergic diseases.

The tablets are taken orally before meals. The dose depends on the characteristics of the disease and the age of the patient.

In addition, in some cases, the patient may be prescribed intravenous administration of the solution. In case of allergies, calcium gluconate is not recommended to be administered intramuscularly or subcutaneously (especially to children).

The course of treatment for allergies usually lasts from 7 to 14 days.

Calcium gluconate for allergies (reviews are eloquent confirmation of this) is a time-tested and quite effective remedy, which, on top of everything, is almost impossible to overdose on.

Maximum absorption of calcium is ensured with the participation of vitamin D, amino acids (in particular L-arginine and lysine) and Ca-binding protein.

Contraindications

Contraindications to the use of solution and tablets:

Side effects

The drug is usually well tolerated, but in some cases the following disorders are possible:

  • bradycardia;
  • hypercalciuria, hypercalcemia;
  • nausea, vomiting, stool disorders (constipation/diarrhea), epigastric pain;
  • formation of calcium stones in the intestines (with long-term use of high doses of the drug);
  • impaired renal function (swelling of the lower extremities, frequent urination);
  • hypersensitivity reactions.

With parenteral administration, nausea, vomiting, bradycardia, diarrhea, a feeling of heat in the mouth and then throughout the body, and changes in the skin may sometimes be observed. These reactions pass quite quickly and do not require special treatment.

With rapid administration of the solution, nausea, increased sweating, vomiting, arterial hypotension, and collapse (in some situations, lethal) may occur. The result of extravasal penetration of the solution can be calcification of soft tissues.

In very rare cases, allergic and anaphylactic reactions have been recorded.

When calcium gluconate is administered intramuscularly, local irritation and tissue necrosis are possible.

Instructions for use of Calcium gluconate

Calcium gluconate tablets, instructions for use

The tablets are taken before meals, after crushing or chewing.

A single dose for patients over 14 years of age is from 1 to 3 g (2-6 tablets for each dose). Patients 3-14 years old are given 2-4 tablets. 2-3 rubles/day.

Treatment lasts from 10 days to 1 month. The duration of the course is determined by the attending physician individually depending on the patient’s condition.

The permissible upper limit of the daily dose for elderly patients is 4 tablets. (2 g).

Ampoules Calcium gluconate, instructions for use

Calcium gluconate is administered intravenously or intramuscularly.

For patients over 14 years of age, injections are given once a day. A single dose is from 5 to 10 ml of solution. Depending on the patient’s condition, injections can be given daily, every other day or once every two days.

For children from birth to 14 years of age, the dose of 10% calcium gluconate solution intravenously varies from 0.1 to 5 ml.

Before administration, the drug should be warmed to body temperature. The medicine should be administered slowly - over 2-3 minutes.

To administer less than one milliliter of solution, it is recommended to dilute a single dose to the required volume (syringe volume) with a 5% glucose solution or 0.9% NaCl solution.

Overdose

With long-term treatment with high doses of calcium gluconate, the risk of developing hypercalcemia with the deposition of Ca salts in the body increases. The likelihood of hypercalcemia increases with the simultaneous use of high doses of vitamin D or its derivatives.

To eliminate the symptoms of overdose, the drug should be discontinued. In severe cases, the patient is prescribed intravenous calcitonin at a rate of 5-10 MO/kg/day. The product is diluted in 0.5 liters of 0.9% NaCl solution and administered dropwise over six hours. Slow drip administration of the antidote 2-4 times a day is also allowed.

Interaction

  • slows down the absorption of etidronate, estramustine, bisphosphonates, tetracycline antibiotics, quinolones, fluoride and iron preparations for oral administration (an interval of at least 3 hours should be maintained between their doses).
  • reduces the bioavailability of phenytoin;
  • enhances the cardiotoxicity of cardiac glycosides;
  • in patients with hypercalcemia, it reduces the effectiveness of calcitonin;
  • reduces the effects of calcium channel blockers;
  • increases the toxicity of quinidine.

In combination with quinidine, it provokes a slowdown in intraventricular conduction; in combination with thiazide diuretics, the risk of developing hypercalcemia increases. Vitamin D and its derivatives help increase calcium absorption. Cholestyramine reduces Ca absorption in the gastrointestinal tract.

Forms insoluble or slightly soluble Ca salts with salicylates, carbonates, and sulfates.

Certain foods (for example, rhubarb, bran, spinach, cereals) can reduce the absorption of Ca from the digestive tract.

Not compatible with the solution:

Terms of sale

The tablets are an over-the-counter product. To purchase ampoules with solution, a prescription is required.

Recipe in Latin (sample): Rp.: Sol. Calcii gluconatis 10% 10 ml Dtd 6 ampull. S. For intramuscular or intravenous administration (0.5-1 amp.).

Storage conditions

Store at temperatures below 25°C. Keep away from children.

Best before date

Solution - 2 years. Tablets - 5 years.

special instructions

Due to the possibility of developing necrosis, calcium gluconate should be administered exclusively intravenously to children under 14 years of age.

Before filling the syringe, ensure that there is no residual alcohol in it (a sediment may form).

Treatment of patients with a history of urolithiasis, reduced glomerular filtration rate or mild hypercalciuria should be carried out under the control of Ca2+ levels in the urine. To reduce the risk of developing urolithiasis, it is recommended to drink enough fluids.

“Pharaoh's snake” from calcium gluconate

Calcium gluconate tablets are often used by enthusiastic chemists to produce “pharaoh’s snake,” a porous product that is formed from a small amount of reacting substances.

The tablet is placed on dry fuel, and then the fuel is set on fire. A light gray “snake” with white spots begins to crawl out of the tablet. Moreover, the volume of the “pharaoh snake” significantly exceeds the volume of the original substance: for example, in some experiments, snakes 10-15 cm long were obtained from 1 tablet.

During the decomposition of calcium gluconate, Ca oxide, carbon dioxide, carbon and water are formed. The characteristic shade of the resulting snake is given by Ca oxide. The only drawback of such a “pharaoh snake” is its fragility; it crumbles very easily.

Analogs

Calcium gluconate for children

Why is calcium gluconate prescribed to children?

In the articles, Dr. Komarovsky notes that the most common indications for the use of the drug in pediatrics are conditions caused by insufficient intake of calcium into the body from food, as well as conditions caused by impaired absorption of calcium in the intestine.

The development of hypocalcemia, along with a reduced content of Ca in food, is also promoted by hypovitaminosis D. In addition, certain diseases of the parathyroid glands and thyroid gland can cause hypocalcemia.

In addition to these diseases and rickets, indications for prescribing Ca drugs for children are allergic diseases (acute or chronic), skin diseases, pathologies manifested by blood clotting disorders, physiological conditions that are accompanied by an increase in the child’s body’s need for Ca (periods of active growth).

How to take Calcium Gluconate correctly?

For children, Komarovsky recommends dosing calcium gluconate depending on age. In the first 12 months of a child’s life, the standards for daily Ca intake range from 0.21 to 0.27 g. Children under 3 years of age require 0.5 g of Ca per day, children 4-8 years old - 0.8 g, children over eight years of age - 1-1.3 g.

As a rule, children get Ca from dairy products, greens, fruits, vegetables and nuts.

Children under 12 months are given 3 tablets per day (1.5 g), children under 4 years old - 6 tablets per day (3 g), children under 9 years old - depending on the severity of calcium deficiency and the characteristics of the clinical situation - 6-12 tablets. day (3-6 g), for children under 14 years old - every day (6-9 g).

The daily dose is divided into 2-4 doses.

The drug is usually administered intravenously to children as an emergency treatment: for bleeding, convulsions, acute allergic reactions.

The solution is not administered subcutaneously or intramuscularly to children. Medicine can only be injected into the muscle in adult patients!

Calcium gluconate during pregnancy

During pregnancy and during breastfeeding, the use of the drug is possible taking into account the ratio of benefit to the mother/risk to the fetus (child).

Only the attending physician can say for sure whether pregnant women can take Calcium Gluconate in each specific case.

When taking Ca preparations during lactation, they may penetrate into milk.

Reviews of Calcium gluconate

The most common reviews of the drug Calcium Gluconate are reviews for allergies. The drug is prescribed to both adults and very young children. At the same time, most people consider it a worthy alternative to more expensive and advertised medications.

To compensate for calcium deficiency, tablets are usually prescribed, but in some situations the drug is administered intravenously or into a muscle.

Reviews of calcium gluconate injections intramuscularly suggest that the procedure is quite painful. Moreover, unpleasant sensations usually occur not during the injection, but after it.

Reviews about calcium gluconate intramuscularly indicate that intravenous injections are tolerated somewhat easier than injections into the muscle. However, it should be remembered that the injection is “hot”, and after it you should not stand up suddenly.

Despite the pain of injections, the drug helps well with allergies, pityriasis rosea, heavy periods, prolonged sore throat, herpes and a number of other pathologies. In pregnant women, after treatment with calcium gluconate, leg cramps are significantly reduced, nails and teeth are strengthened.

However, you should not forget that the product is a medical drug, so only a doctor can recommend treatment for it.

Calcium gluconate price

The price of Calcium gluconate tablets in Russian pharmacies is from 3.5 rubles. for 10 pieces. The cost of packaging No. 30 is rub. In Ukraine you can buy 10 tablets from 3.85 UAH.

A 10% solution in Ukrainian pharmacies costs from 17 UAH (5 ml ampoules, No. 10). The price of an ampoule of 5 ml (No. 1) is 1.8 UAH. In Russia, the price of Calcium gluconate injections is from 118 rubles.

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Calcium gluconate - instructions for use, analogs, reviews and release forms (tablets 500 mg, injections in ampoules for intramuscular and intravenous injections) of the drug for the treatment of hypocalcemia in adults, children and pregnancy

In this article you can read the instructions for use of the drug Calcium gluconate. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Calcium gluconate in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of calcium gluconate in the presence of existing structural analogues. Use for the treatment of osteoporosis and other forms of calcium deficiency in the body in adults, children, as well as during pregnancy and lactation.

Calcium gluconate is a calcium preparation that replenishes the deficiency of calcium ions necessary for the transmission of nerve impulses, contraction of skeletal and smooth muscles, myocardial activity, bone tissue formation, and blood clotting.

Calcium is a macroelement involved in the formation of bone tissue, the process of blood clotting, and is necessary to maintain stable cardiac activity and the processes of transmission of nerve impulses. Improves muscle contraction in muscular dystrophy, myasthenia gravis, and reduces vascular permeability. When administered intravenously, calcium excites the sympathetic nervous system and increases the secretion of adrenaline by the adrenal glands; has a moderate diuretic effect.

Approximately 1/5-1/3 of the orally administered drug is absorbed in the small intestine; this process depends on the presence of vitamin D, pH, diet and the presence of factors that can bind calcium ions. The absorption of calcium ions increases with calcium deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the remaining amount (80%) is removed with the contents of the intestine.

  • diseases accompanied by hypocalcemia, increased permeability of cell membranes (including blood vessels), disruption of the conduction of nerve impulses in muscle tissue;
  • hypoparathyroidism (latent tetany, osteoporosis), vitamin D metabolism disorders: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal failure;
  • increased need for calcium ions (pregnancy, lactation, period of increased growth of the body), insufficient content of calcium ions in food, disturbance of its metabolism (in the postmenopausal period);
  • increased excretion of calcium ions (prolonged bed rest, chronic diarrhea, secondary hypocalcemia due to long-term use of diuretics and antiepileptic drugs, glucocorticosteroids);
  • poisoning with salts of magnesium ions, oxalic and fluoric acids and their soluble salts (when interacting with calcium gluconate, insoluble and non-toxic calcium oxalate and calcium fluoride are formed);
  • hypercalcemic form of paroxysmal myoplegia.

Tablets 500 mg

Chewable tablets 500 mg.

Solution for intravenous and intramuscular administration (injections) in ampoules of 100 mg/ml.

Instructions for use and dosage

Grind before use.

Orally, before meals or 1-1.5 hours after consumption (with milk). Adults: 2-3 times a day (maximum daily dose - 9 g).

Pregnant and lactating mothers: 2-3 times a day (maximum daily dose - 9 g).

Children: 3-4 years old - 1 g (maximum daily dose - 3.0 g); 5-6 years - 1-1.5 g (maximum daily dose - 4.5 g); 7-9 years - 1.5-2 g (maximum daily dose - 6 g); years (maximum daily dose - 9 g); dosage frequency: once a day.

When administering calcium gluconate solution intravenously or intramuscularly, a single dose of the drug should correspond to 2.25-4.5 mmol of calcium. A solution of calcium chloride is administered intravenously in a stream (slowly) in a single dose of 500 mg, intravenously in a drip - in a single dose of 0.5-1 g.

  • constipation;
  • irritation of the mucous membrane of the gastrointestinal tract;
  • hypercalcemia.
  • hypersensitivity;
  • hypercalcemia (calcium ion concentration should not exceed 12 mg%);
  • severe hypercalciuria;
  • nephrourolithiasis (calcium);
  • tendency to thrombosis;
  • sarcoidosis;
  • simultaneous use of cardiac glycosides (risk of arrhythmias);
  • children under 3 years of age.

Use during pregnancy and breastfeeding

Application is possible according to the dosage regimen.

In patients with mild hypercalciuria, decreased glomerular filtration rate, or a history of nephrourolithiasis, treatment should be carried out under the control of the concentration of calcium ions in the urine.

To reduce the risk of developing nephrourolithiasis, drinking plenty of fluids is recommended.

Calcium gluconate has similar effects to calcium chloride, but is less irritating.

Forms insoluble complexes with tetracycline antibiotics (reduces the antibacterial effect).

When used simultaneously with quinidine, intraventricular conduction may slow down and the toxicity of quinidine may increase.

Slows down the absorption of tetracyclines, digoxin, and oral iron supplements (the interval between doses should be at least 2 hours).

When combined with thiazide diuretics, it may increase hypercalcemia. Reduces the effect of calcitonin in hypercalcemia. Reduces the bioavailability of phenytoin.

Analogues of the drug Calcium gluconate

Structural analogues of the active substance:

  • Calcium gluconate B. Brown;
  • Stabilized calcium gluconate;
  • Calcium gluconate-Vial;
  • Calcium gluconate-LekT;
  • Calcium gluconate solution for injection 10%.

Similar medications:

Other medicines:

News edited by: admin016, 12:04

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Calcium gluconate

Prices in online pharmacies:

Calcium gluconate is a medication used to regulate calcium-phosphorus metabolism.

Pharmacological action of Calcium gluconate

The action of the drug Calcium gluconate is aimed at replenishing Ca2+ deficiency, in which:

  • The process of transmission of nerve impulses deteriorates;
  • Contractions of smooth and skeletal muscles, bone formation, myocardial activity, and blood clotting are disrupted.

Release form, composition and analogues of Calcium gluconate

Calcium gluconate containing the active substance of the same name is produced in the form:

  • Chewable tablets 500 mg;
  • Solution for injection in ampoules of 1, 2, 3, 5 and 10 ml;
  • Tablets of 250 and 500 mg.

According to indications, the doctor may recommend one of the drug analogues with a similar effect. For example: Additive calcium, Hydroxyapatite, Glycerophosphate granules, Hydroxyapatite paste, CalViv, Calcium-Sandoz forte, Calcium lactate, Calcium lactate.

Indications for use of Calcium gluconate

Calcium gluconate injections and tablet form of the drug are prescribed for the treatment of:

  • Hypoparathyroidism (latent tetany, osteoporosis);
  • Diseases accompanied by hypocalcemia, increased permeability of cell membranes, disorders in muscle tissue in the conduction of nerve impulses;
  • Increased excretion of Ca2+, which occurs during prolonged bed rest, chronic diarrhea, secondary hypocalcemia due to prolonged use of diuretics, antiepileptic drugs, glucocorticosteroids;
  • Vitamin D metabolism disorders, including rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic kidney disease;
  • Hyperkalemic form of paroxysmal myoplegia;
  • Poisoning with Mg2+ salts, fluoric and oxalic acids, as well as their soluble salts.

Also, Calcium gluconate according to the instructions is prescribed against the background of an increased need for Ca2+, which occurs in children and adolescents during periods of intensive growth, with an unbalanced diet, which causes a deficiency of Ca2+, as well as in the postmenopausal period with disturbances in calcium-phosphorus metabolism.

For women, calcium gluconate is usually prescribed during pregnancy and lactation due to the increasing need for calcium during this period.

Contraindications

The medicine is not used against the background:

  • Hypercalcemia;
  • Hypersensitivity;
  • Nephrourolithiasis (calcium);
  • Severe hypercalciuria;
  • Concomitant use with cardiac glycosides (due to the risk of arrhythmias);
  • Sarcoidosis.

In pediatrics, the medication in any dosage form is approved for use from the age of three.

When using Calcium gluconate, caution must be exercised when:

  • Electrolyte disturbances (due to an increased risk of developing hypercalcemia);
  • Dehydration;
  • Malabsorption syndrome;
  • Diarrhea;
  • Slight hypercalciuria;
  • Calcium nephrourolithiasis (history);
  • Chronic heart failure;
  • Moderate chronic renal failure;
  • Hypercoagulation;
  • Widespread atherosclerosis.

How to use Calcium gluconate

Calcium gluconate tablets are taken before meals or 1-1.5 hours after meals. It is recommended to take the medicine with milk. Adult daily dosage varies from 2 to 9 g depending on indications, children - from 1 g depending on age. The frequency of use of tablets is 2-3 times a day.

Calcium gluconate injections with a 10% solution at room temperature are given intramuscularly, slowly intravenously (2-3 minutes) or by drip. Depending on the indications, the medication is administered daily or every other day.

To reduce the risk of developing nephrourolithiasis during therapy, drinking plenty of fluids is recommended.

The dosage of calcium gluconate during pregnancy and lactation should be checked with your doctor.

Side effects

When taking Calcium gluconate tablets, constipation and irritation of the mucous membrane of the gastrointestinal tract may occur.

When administered intramuscularly or intravenously, calcium gluconate, according to reviews, can lead to the development of:

  • Nausea;
  • Vomiting;
  • Diarrhea;
  • Bradycardia;
  • Burning sensation in the mouth;
  • Feelings of heat;
  • Reducing blood pressure;
  • Arrhythmias;
  • Fainting;
  • Cardiac arrest;
  • Necrosis at the injection site.

When using increased dosages of calcium gluconate, according to reviews, it can cause hypercalcemia, for the treatment of which calcitonin is used parenterally.

Drug interactions Calcium gluconate

During therapy, it should be taken into account that calcium gluconate, according to the instructions, is pharmaceutically incompatible with salicylates, carbonates and sulfates.

You should also know that Calcium gluconate simultaneously with:

  • Tetracycline antibiotics form insoluble complexes, which reduces the antibacterial effect;
  • BMCC leads to a decrease in its effect;
  • Quinidine can slow down intraventricular conduction and cause increased toxicity;
  • With tetracyclines, digoxin, and oral medications, Fe slows down their absorption. The interval between medications should be at least two hours;
  • Thiazide diuretics enhances hypercalcemia;
  • Calcitonin reduces its effect when used against the background of hypercalcemia;
  • Phenytoin reduces its bioavailability.

Storage conditions

Calcium gluconate is one of the regulators of calcium-phosphorus metabolism, dispensed from pharmacies only as prescribed by a doctor. The shelf life of tablets is 5 years, chewable tablets - 24 months, solution for injection - 2.5 years, provided the medicine is stored in accordance with the manufacturer's recommendations.

Calcium gluconate tab. 0.5g No. 10

Calcium gluconate eco 500 mg N10 tablet

Calcium gluconate "Eco" tablets 500 mg unflavored

Calcium gluconate tab. 500mg n10

Calcium gluconate 500 mg No. 10 tablets

Calcium gluconate tablets 500 mg 20 pcs.

Calcium gluconate tablets 500 mg 10 pcs.

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Source: http://zdorovi.net/preparaty/kalcija-gljukonat.html

Calcium gluconate Tablets, Tablets

CALCIUM GLUCONATE

International nonproprietary name

One tablet contains

active substance - calcium gluconate monohydrate 500 mg,

excipients: potato starch, talc, calcium stearate.

White flat-cylindrical tablets, with a chamfer and a score. Marbling is allowed on the surface of the tablets.

Mineral supplements. Calcium preparations

ATX code A12AA03

Pharmacokinetics

Approximately 1/5-1/3 of the orally administered drug is absorbed in the small intestine. This process depends on the influence of vitamin D, the acidity of the intestinal contents, diet and the presence of factors that can bind calcium ions. Calcium absorption increases with its deficiency in the body and in food. About 20% of calcium is excreted by the kidneys, the remaining 80% is removed with the contents of the intestine (calcium is actively released through the wall of the terminal intestine).

Pharmacodynamics

Calcium ions take part in the formation of bone tissue, the process of blood clotting, and are necessary to maintain stable cardiac activity and carry out the processes of transmission of nerve impulses. A decrease in the content of calcium ions in blood plasma and tissues can lead to the development of various pathological processes. Hypocalcemia leads to dysfunction of skeletal and smooth muscles, the cardiovascular system, disruption of the blood coagulation system, and the development of osteoporosis.

— hypoparathyroidism (latent tetany, osteoporosis), vitamin D metabolism disorders: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal failure

- increased need for calcium (pregnancy, breastfeeding, period of increased body growth), insufficient calcium content in food, impaired calcium metabolism (in the postmenopausal period)

- increased excretion of calcium from the body of various origins (prolonged bed rest, chronic diarrhea, secondary hypocalcemia due to long-term use of diuretics, antiepileptic drugs and glucocorticosteroids)

- poisoning with magnesium salts, oxalic and fluoric acids and their soluble salts (when interacting with calcium gluconate, insoluble and non-toxic calcium oxalate and calcium fluoride are formed)

- hyperkalemic form of paroxysmal myoplegia

Directions for use and doses

Before starting use, consult your doctor.

The drug is taken orally before meals or 1.5-2 hours after meals, washed down with milk.

The dosage regimen and duration of taking the drug for each indication depend on the patient’s condition and are determined by the doctor in accordance with the treatment regimens given below. Adults and children over 14 years old - 1.0-3.0 g (2-6 tablets) 2-3 times a day; children from 3 to 5 years old - 1.0 g (2 tablets) 2-3 times a day; from 5 to 7 years - 1.0-1.5 g (2-3 tablets) 2-3 times a day; from 7 to 10 years - 1.5-2.0 g (3-4 tablets) 2-3 times a day; from 10 to 14 years - 2.0-3.0 g (4-6 tablets) 2-3 times a day.

The course of taking the drug depends on the patient’s condition and is recommended by the doctor.

- irritation of the mucous membrane of the gastrointestinal tract

- nausea, vomiting, diarrhea

- shortness of breath or difficulty breathing

- feeling of heaviness or weakness in the legs

If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Contraindications

— hypercalcemia (calcium ion concentration should not exceed 12 mg% = 6 mEq/l)

- severe renal failure

- simultaneous use of cardiac glycosides (risk of arrhythmias)

- children up to 6 years old

- dehydration, electrolyte disturbances

- diarrhea, history of calcium nephrolithiasis

- malabsorption syndrome, widespread atherosclerosis

-moderate chronic renal and/or cardiovascular failure

- hypercoagulability, ventricular fibrillation

If you have one of the listed diseases, you should consult your doctor before taking the drug.

Calcium gluconate is pharmaceutically incompatible with carbonates, salicylates, and sulfates, as it precipitates them to form insoluble and sparingly soluble calcium salts.

Concomitant use of calcium gluconate with thiazide diuretics leads to increased hypercalcemia.

Taking calcium gluconate reduces the effect of calcitonin in hypercalcemia and also reduces the bioavailability of phenytoin.

Due to the formation of insoluble complexes, it is incompatible with licorice root preparations and tetracycline antibiotics (reduces the antibacterial effect).

Slows down the absorption of digoxin, tetracyclines, iron preparations, clindamycin phosphate, hydrocortisone succinate, salicylates for oral administration (the interval between taking calcium gluconate and the listed drugs should be at least 2 hours). With the simultaneous use of calcium gluconate with quinidine, intraventricular conduction may slow down and the toxicity of quinidine may increase. When used together, it enhances the antiresorptive effect of vitamin D, ossien hydroxyapatite complex, anabolic steroids and estrogens. Enhances the hemostatic effect of vitamin K. Reduces the toxicity of bisphosphonates and fluorides when used together. Pharmaceutically incompatible with magnesium preparations.

The drug does not affect the ability to drive a car or control various mechanisms, as well as engage in other potentially dangerous activities that require increased attention and speed of mental and motor reactions. Patients with a tendency to form kidney stones are advised to increase their fluid intake.

Use during pregnancy and breastfeeding

During pregnancy and during breastfeeding, the use of the drug is possible on the recommendation of a doctor. The daily dose of calcium during pregnancy should not exceed 1500 mg. If necessary, use during lactation should stop breastfeeding.

Symptoms: elevated serum calcium levels. With a chronic overdose of calcium preparations, general and muscle weakness, depression, mental disorders, loss of appetite, nausea, vomiting, constipation, decreased blood pressure, and heart rhythm disturbances may develop.

Treatment: discontinuation of the drug, parenteral administration of calcitonin at a dose of 5-10 IU/kg/day in 500 ml of 0.9% sodium chloride solution for 6 hours.

Release form and packaging

10 tablets in a contoured cell-free package made of a combination of paper and cardboard material.

Contour cellless packaging, together with instructions for use (insert notes) in the state and Russian languages, are placed in group containers.

The number of instructions for use (insert notes) must correspond to the number of packages.

Store at a temperature not exceeding 25 °C.

Keep out of the reach of children!

The drug should be used before the date indicated on the package!

Conditions for dispensing from pharmacies

Manufacturer

OJSC Pharmstandard-Leksredstva,

Russia, Kursk, 2nd Aggregatnaya st., 1a/18

Tel/fax: (4

Registration Certificate Holder

OJSC Pharmstandard-Leksredstva, Russia

Address of the organization that accepts claims from consumers regarding product quality on the territory of the Republic of Kazakhstan

OJSC Pharmstandard-Leksredstva,

Russia, Kursk, 2nd Aggregatnaya st., 1a/18

Tel/fax: (4

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