Fluimucil mucolytic agent instructions for use

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Mucolytic drug "Fluimucil": instructions for use

The instructions for use define the drug "Fluimucil" as a mucolytic agent that has a pronounced antioxidant effect. The use of this medicine reduces the adhesion of bacteria on the cells of the bronchial mucosa, thins the mucus and greatly facilitates its separation.

Table of contents:

At the same time, the basis of the action of the drug “Fluimucil”, the instructions for use of which also indicate this, is the breaking of inter- and intramolecular disulfide bonds of mucopolysaccharides, which, in turn, leads to a decrease in the viscosity of the pathological secretion and depolarization of mucoproteins. It should be especially noted that this mucolytic drug has a similar effect on the secretions formed during various types of inflammatory infections of the ENT organs. In addition, it remains active in the presence of purulent sputum. If we consider the pharmacokinetics of the drug "Fluimucil", then its highest plasma concentrations are observed one to three hours after use, and the half-life is about sixty minutes.

Features of the release form

This mucolytic drug is produced in the form of effervescent tablets with a strong lemon and moderate sulfur odor. As an active element, the drug "Fluimucil" contains six hundred milligrams of acetylcysteine. Additional ingredients include citric acid, sodium bicarbonate, lemon flavor and aspartame.

The instructions for use advise people suffering from tracheitis, bronchitis, bronchiectasis and bronchiolitis to take Fluimucil tablets. In addition, this mucolytic agent can be used for interstitial lung diseases, lung abscess, pneumonia and emphysema. For cystic fibrosis and laryngotracheitis, the use of the drug "Fluimucil" is also indicated. Reviews also note good results from its use for sinusitis, pulmonary atelectasis (due to bronchial obstruction) and sinusitis. Various postoperative and post-traumatic conditions (for example, after removal of viscous secretions) are also reasons for prescribing this remedy.

Contraindications for use

The instructions for use do not advise women carrying a child, people with hypersensitivity to acetylcysteine ​​and those who suffer from stomach ulcers or duodenal ulcers to take Fluimucil tablets. In case of pulmonary bleeding or hemoptysis, it is also strictly not recommended to start taking this mucolytic drug. In addition, Fluimucil is not prescribed for children under eighteen years of age. During lactation and with phenylketonuria, you should also not take this medicine. Fluimucil tablets are prescribed with great caution for diseases of the adrenal glands, renal failure, bronchial asthma, liver failure and arterial hypertension.

Main side effects

Prolonged use of this mucolytic agent in certain groups of patients may cause vomiting, nausea, itching and skin rash. Conditions such as diarrhea, heartburn, hives, tinnitus and nosebleeds may also occur.

Source: http://www.syl.ru/article/107467/mukoliticheskiy-preparat-fluimutsil-instruktsiya-po-primeneniyu

Fluimucil - instructions for use, analogs, reviews and release forms (granules 200 mg, powder, solution for inhalation antibiotic IT in ampoules, effervescent tablets 600 mg) of a drug for the treatment of cough in adults, children and pregnancy

In this article you can read the instructions for use of the drug Fluimucil. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Fluimucil in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Fluimucil in the presence of existing structural analogues. Use for the treatment of cough and thinning of sputum in adults, children, as well as during pregnancy and breastfeeding.

Fluimucil is a mucolytic drug. Liquefies mucus, increases its volume and facilitates its separation. The effect of acetylcysteine ​​(the active ingredient of the drug Fluimucil) is associated with the ability of its sulfhydryl groups to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolarization of mucoproteins and a decrease in sputum viscosity. Remains active in the presence of purulent sputum.

Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs.

It has an antioxidant effect due to the presence of an SH group that can neutralize electrophilic oxidative toxins.

Acetylcysteine ​​easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant and cytoprotector that neutralizes endogenous and exogenous free radicals and toxins. Acetylcysteine ​​prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, promoting the detoxification of harmful substances. This explains the effect of acetylcysteine ​​as an antidote for paracetamol poisoning.

Protects alpha1-antitrypsin (elastase inhibitor) from the inactivating effects of HOCl, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue).

Acetylcysteine ​​+ excipients.

Thiamphenicol glycinate acetylcysteinate + excipients (Fluimucil antibiotic IT).

When taken orally, it is well absorbed from the gastrointestinal tract. Penetrates into the intercellular space, predominantly distributed in the liver, kidneys, lungs, and bronchial secretions. Penetrates through the placental barrier. Rapidly deacetylated to cysteine ​​in the liver. In the plasma, a mobile equilibrium of free acetylcysteine ​​and its metabolites (cysteine, cystine, diacetylcystine) is observed, free and bound to plasma proteins. It is excreted in the urine in the form of inactive metabolites (inorganic sulfates, diacetylcysteine), a small part is excreted unchanged through the intestines.

  • respiratory diseases accompanied by impaired sputum discharge (including bronchitis, tracheitis, bronchiolitis, pneumonia, bronchiectasis, cystic fibrosis, lung abscess, pulmonary emphysema, laryngotracheitis, interstitial lung diseases, pulmonary atelectasis (due to blockage of the bronchi by mucus plug));
  • catarrhal and purulent otitis, sinusitis, incl. sinusitis (to facilitate the passage of secretions);
  • to remove viscous secretions from the respiratory tract in post-traumatic and postoperative conditions;
  • preparation for bronchoscopy, bronchography, aspiration drainage;
  • for washing abscesses, nasal passages, maxillary sinuses, middle ear, treatment of fistulas, surgical field during operations on the nasal cavity and mastoid process;
  • with concomitant nonspecific forms of respiratory infections to improve drainage, including cavernous lesions, with mycobacterial infections.

Solution for injection and inhalation (sometimes mistakenly called syrup).

Effervescent tablets 600 mg.

Granules for the preparation of a solution for oral administration 200 mg (sometimes mistakenly called powder).

Lyophilisate for the preparation of solution for injection and inhalation in ampoules (Fluimucil antibiotic IT).

Instructions for use and method of use

For aerosol therapy, 3-9 ml of a 10% solution is sprayed in ultrasound devices, and 6 ml of a 10% solution is sprayed in devices with a distribution valve. Duration of inhalation min; frequency: once a day. When treating acute conditions, the average duration of therapy is days; for long-term therapy of chronic conditions, the course of treatment is up to 6 months.

Due to the high safety of the drug, the frequency of administration and the relative dose can be changed by the doctor within acceptable limits, depending on the patient’s condition and the therapeutic effect. There is no need to change the adult dose when using the drug to treat children. In the case of a strong secretolytic effect, the secretion is sucked out, and the frequency of inhalations and the daily dose are reduced.

The therapeutic mixture cannot be placed in an ultrasonic nebulizer, because it quickly destroys the active substance Fluimucil. It is advisable to use a compressor device for inhalation, which provides an ideal setting for the size of the inhaled particles of the drug.

To wash the bronchial tree during therapeutic bronchoscopy, use 1-2 ampoules or more per day, depending on clinical indications.

Instill in the external auditory canal and nasal passages (in the nose) mg (1.5-3 ml) for 1 procedure.

Administer intravenously (preferably drip or slow stream over 5 minutes) or intramuscularly. Adults - 300 mg (3 ml) 1-2 times a day; children from 6 to 14 years old - 150 mg (1.5 ml) 1-2 times a day. The daily dose for children under 6 years of age is 10 mg/kg body weight; for children under 1 year of age, intravenous administration of acetylcysteine ​​is possible only for health reasons in a hospital setting. The duration of treatment should be determined based on changes in the patient's condition.

It should be taken into account that oral administration of the drug is preferable for children under 6 years of age.

High local and general tolerability of the drug allows for long courses of treatment.

For intravenous administration, the solution is further diluted with 0.9% sodium chloride solution or 5% dextrose solution in a 1:1 ratio. The duration of therapy is determined individually (no more than 10 days).

In patients over 65 years of age, the minimum effective dose is used.

The drug in the form of effervescent tablets is prescribed to adults at 600 mg (1 tablet) 1 time per day. Before use, the effervescent tablet is dissolved in 1/3 glass of water.

Granules for preparing a solution for oral administration are prescribed to adults and children over 6 years old - 200 mg 2-3 times a day; children aged 2 to 6 years - 200 mg 2 times a day or 100 mg 3 times a day; children aged 1 to 2 years - 100 mg 2 times a day.

In newborns, the drug is used only for health reasons at a dose of 10 mg/kg body weight under the strict supervision of a physician.

Before use, the required amount of granules is dissolved in 1/3 glass of water. Children of the first year of life are given the resulting solution to drink from a spoon or feeding bottle.

The duration of the course of treatment is determined individually. For acute diseases, the duration of treatment is from 5 to 10 days, for chronic diseases - up to several months.

  • reflex cough;
  • respiratory tract irritation;
  • rhinorrhea;
  • stomatitis;
  • bronchospasm;
  • burning at the injection site;
  • skin rash;
  • hives;
  • impaired liver and/or kidney function (with long-term use).
  • peptic ulcer of the stomach and duodenum in the acute phase;
  • lactation period;
  • children under 2 years of age (for granules for the preparation of a solution for oral administration);
  • children and adolescents up to 18 years of age (for effervescent tablets);
  • anemia;
  • leukopenia;
  • thrombocytopenia;
  • hypersensitivity to acetylcysteine.

Use during pregnancy and breastfeeding

During pregnancy, the use of Fluimucil is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped.

For patients with bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

With shallow intramuscular injection of the drug and in the presence of increased sensitivity, a slight and quickly passing burning sensation may appear, and therefore it is recommended to inject the drug deep into the muscle.

The Fluimucil ampoule is opened before use. An opened ampoule can be stored in the refrigerator for 24 hours, during which time the drug can only be used for inhalation.

Fluimucil solution should not come into contact with rubber and metal surfaces.

Prescribed with caution for peptic ulcers of the stomach and duodenum in remission, varicose veins of the esophagus, hemoptysis, pulmonary hemorrhage, bronchial asthma (with intravenous administration the risk of developing bronchospasm increases), diseases of the adrenal glands, liver and/or kidney failure, arterial hypertension, and also for children under 6 years of age.

For children under 1 year of age, intravenous administration of acetylcysteine ​​is possible only for health reasons in a hospital setting.

The simultaneous use of Fluimucil with antitussives may increase sputum stagnation due to suppression of the cough reflex.

When used simultaneously with antibiotics, such as tetracyclines (excluding doxycycline), ampicillin, amphotericin B, they may interact with the thiol group of acetylcysteine, which leads to a decrease in the activity of both drugs, so the interval between taking acetylcysteine ​​and antibiotics should be at least 2 hours.

The simultaneous use of Fluimucil and nitroglycerin can lead to an increase in the vasodilatory effect of the latter.

Acetylcysteine ​​reduces the hepatotoxic effect of paracetamol.

Pharmaceutically incompatible with other drug solutions.

Analogues of the drug Fluimucil

Structural analogues of the active substance:

  • N-AC-ratiopharm;
  • N-acetylcysteine;
  • Acestine;
  • Acetylcysteine;
  • Acetylcysteine ​​solution for inhalation 20%;
  • Acetylcysteine ​​solution for injection 10%;
  • ACC;
  • ACC 100;
  • ACC 200;
  • ACC injection;
  • ACC Long;
  • Vicks Active ExpectoMed;
  • Mukobene;
  • Mucomist;
  • Mukonex;
  • Fluimucil;
  • Exomyuk 200.

Similar medications:

Other medicines:

News edited by: admin017, 12:37

Source: http://instrukciya-otzyvy.ru/571-fluimucil-po-primeneniyu-analogi-granuly-poroshok-rastvor-ingalyaciya-antibiotik-it-tabletka.html

Fluimucil - instructions and price

  • ATX code: R05CB01
  • Release form: tablets, solution, granules, lyophilisate

Introduction to instructions for use

1. Pharmacological action

Drug group:

Therapeutic effects of Fluimucil:

  • Increasing the volume and facilitating the separation of sputum;

Peculiarities:

  • The drug is quickly absorbed and penetrates into the intercellular space, concentrating mainly in the kidneys, lungs, liver and bronchial secretions.

2. indications for use

The drug is used for:

  • Treatment of various diseases accompanied by difficulty in sputum discharge;

3. Method of application

Recommended dosage of Fluimucil in the form of granules:

Recommended dosage of Fluimucil in the form of effervescent tablets:

Recommended dosage of Fluimucil in the form of injection solution:

Features of using Fluimucil:

  • Use of the drug for the treatment of chronic diseases can last up to 3 months;

4. Side effects

  • Digestive system: nausea, diarrhea, vomiting, stomatitis;

5. Contraindications

  • Exacerbation of a stomach or duodenal ulcer;

6. During pregnancy and lactation

7. Interaction with other drugs

Simultaneous use of Fluimucil with:

8. Overdose

9. Release form

Solution for injection and inhalation. 100 mg/1 ml - amp. 3 ml 5 pcs.

Oral solution 20 mg/ml - vial. 100, 150 or 200 ml 1 piece; 40 mg/ml - vial. 150 or 200 ml 1 pc.

Effervescent tablets, 600 mg - 10 or 20 pcs.

Lyophilisate for preparation. solution for injection. and inhalations. 810 mg - vial. 3 pcs.

10. Storage conditions

  • Dry dark place;

11. Composition

1 packet of solution:

  • acetylcysteine ​​- 20 or 40 mg;

1 tablet:

  • acetylcysteine ​​mg;

1 packet of granules:

  • acetylcysteine ​​mg;

12. Conditions for dispensing from pharmacies

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REVIEWS ABOUT THE DRUG Fluimucil

Adding a new review

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Active ingredients

Pharmacological action

Disease class

  • Pneumonia without specifying the pathogen

Pharmacological group

  • Secretolytics and stimulants of motor function of the respiratory tract

IMPORTANT. The information on the site is provided for informational purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

Source: http://pillsman.org/595-fluimucil.html

Fluimucil

Manufacturer: Zambon SPA (Zambon S.P.A.) Italy

ATS code: R05СВ01

Release form: Solid dosage forms. Effervescent tablets.

General characteristics. Compound:

Active ingredient: 600 mg acetylcysteine.

Excipients: citric acid, sodium bicarbonate, aspartame, lemon flavor.

Pharmacological properties:

Pharmacodynamics. A mucolytic agent that thins sputum, increases its volume, and facilitates the separation of sputum. The action is associated with the ability of free sulfhydryl ipynn acetylcysteine ​​to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolymerization of mucoproteins and a decrease in sputum viscosity. Remains active against purulent sputum.

Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs. It has an antioxidant effect due to the presence of an SH group that can neutralize electrophilic oxidative toxins. Acetylcysteine ​​easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized.

Glutathione is a highly reactive tripeptide, a powerful antioxidant, cytoprotector that traps endogenous and exogenous free radicals and toxins. Acetylcysteine ​​prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, thus promoting the detoxification of harmful substances. This explains the effect of acetylcysteine ​​as an antidote for paracetamol poisoning.

Protects alpha 1-antitrypsin (elastase inhibitor) from the inactivating effects of HOC1, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue).

Pharmacokinetics. Fluimucil is well absorbed when taken orally. It is immediately deacetylated to cysteine ​​in the liver. In the blood, a mobile equilibrium of free acetylcysteine ​​and its metabolites (cysteine, cystine, diacetylcysteine) is observed, free and bound to plasma proteins. Due to the high “first pass” effect through the liver, the bioavailability of acetylcysteine ​​is about 10%. Acetylcysteine ​​penetrates into the intercellular space and is predominantly distributed in the liver, kidneys, lungs, and bronchial secretions.

The maximum concentration in plasma is reached 1-3 hours after oral administration and is 15 mmol/l, binding to plasma proteins is 50%. Half-life is about 1 hour, with liver cirrhosis it increases to 8 hours. It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine), a small part is excreted unchanged through the intestines. Penetrates through the placental barrier.

Indications for use:

Removal of viscous secretions from the respiratory tract in post-traumatic and postoperative conditions.

Directions for use and dosage:

Inside. Adults: 1 effervescent tablet 600 mg dissolved in 1/3 glass of water and taken once a day.

The duration of treatment should be assessed individually. For acute diseases, the duration of treatment is from 5 to 10 days; in the treatment of chronic diseases - up to several months (on the recommendation of a doctor).

Features of application:

Use of the drug during pregnancy and lactation. The drug is prescribed during pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus. If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped.

For patients with bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency. The drug contains aspartame, so its use in patients with phenylketonuria is not recommended.

The presence of a slight sulfuric odor is the characteristic odor of the active substance.

When dissolving acetylcysteine, you must use glass containers and avoid contact with metal and rubber surfaces.

Side effects:

When taking acetylcysteine, cases of bronchospasm, collapse, stomatitis, and decreased platelet aggregation have been described.

Interaction with other drugs:

The combined use of acetylcysteine ​​with antitussives may increase sputum stagnation due to suppression of the cough reflex.

When used simultaneously with antibiotics such as tetracyclines (excluding doxycycline), ampicillin, amphotericin B, they may interact with the thiol group of acetylcysteine, which leads to a decrease in the activity of both drugs. Therefore, the interval between doses of these drugs should be at least 2 hours.

The simultaneous use of acetylcysteine ​​and nitroglycerin can lead to an increase in the vasodilating and disaggregating effects of the latter. Acetylcysteine ​​eliminates the toxic effects of paracetamol.

Contraindications:

Hypersensitivity to acetylcysteine, peptic ulcer of the stomach and duodenum in the acute stage, children under 18 years of age, lactation period.

Overdose:

Acetylcysteine ​​when taken at a dose of 500 mg/kg/day does not cause signs and symptoms of overdose.

Storage conditions:

Store at a temperature not exceeding 25 °C. Keep out of the reach of children. Shelf life: 3 years. Do not use after the expiration date stated on the packaging.

Vacation conditions:

Package:

Effervescent tablets 600 mg. 2 or 10 tablets in a blister pack (blister) made of laminated aluminum foil [polyamide - aluminum - polyethylene / polyethylene - aluminum]. 1 or 2 blisters (10 tablets each) or 5 or 10 blisters (2 tablets each) along with instructions for use are placed in a cardboard box.

Published: 03 Dec 2015

Similar drugs

Expectorant mucolytic agent.

Secretolytics and stimulants of motor function of the respiratory tract.

Secretolytics and stimulants of motor function of the respiratory tract.

Expectorant mucolytic agent.

Drugs acting on the respiratory system.

Source: http://www.24farm.ru/preparats/fluimucil_zambon/

FLUIMUCIL

Active substance: acetylcysteine

ATX code: R05CB01

KFG: Mucolytic drug with antioxidant properties

Reg. number: P No. 012975/02

Registration date: 09.14.07

Owner reg. cert.: ZAMBON SWITZERLAND Ltd.

DOSAGE FORM, COMPOSITION AND PACKAGING

Granules for the preparation of an oral solution with orange flavor.

Excipients: aspartame, betacarotene, orange flavor, sorbitol.

Multilayer laminated bags (20) - cardboard packs.

Multilayer laminated bags (60) - cardboard packs.

Effervescent tablets for the preparation of a solution for oral administration are white, round, with a lemon, slightly sulfuric odor; the finished solution is slightly opalescent, with a characteristic odor and taste of lemon flavor.

Excipients: citric acid, sodium bicarbonate, aspartame, lemon flavor.

2 pcs. — cellless contour packages (5) — cardboard packs.

2 pcs. — cellless contour packages (10) — cardboard packs.

10 pieces. — cellless contour packages (1) — cardboard packs.

10 pieces. — cellless contour packages (2) — cardboard packs.

Excipients: disodium edetate, sodium hydroxide, water for injection.

3 ml - dark glass ampoules (5) - plastic holders (1) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

Mucolytic drug. Liquefies mucus and facilitates its release. The action of acetylcysteine ​​is associated with the ability of its sulfhydryl groups to break the disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolarization of mucoproteins and a decrease in mucus viscosity. Remains active in the presence of purulent sputum. Fluimucil has anti-adhesive properties and has an antioxidant effect due to the presence of a nucleophilic thiol SH group, which easily donates hydrogen, neutralizing oxidative radicals.

Acetylcysteine ​​easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized, which is an antioxidant and cytoprotector that neutralizes endogenous and exogenous free radicals and toxins. Thus, acetylcysteine ​​prevents exhaustion and helps increase the synthesis of intracellular glutathione, promoting the detoxification of harmful substances. This explains the effect of acetylcysteine ​​as an antidote for paracetamol poisoning.

When using the drug, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

The BRONCUS (Bronchitis Randomised On NAC Cost Utility Study) study examined the effect of long-term therapy with Fluimucil in moderate to severe chronic obstructive pulmonary disease (COPD).

Fluimucil is able to reduce the frequency of exacerbations of COPD and pulmonary hyperinflation. Its positive effects are especially pronounced in severe COPD.

When taken orally, it is well absorbed from the gastrointestinal tract. After oral administration of 600 mg of acetylcysteine ​​to healthy volunteers, Cmax in plasma is reached after 1 hour and is 15 mmol/l. With intravenous administration of 600 mg of acetylcysteine, Cmax in plasma is 300 mmol/l.

Bioavailability is 10% due to the pronounced “first pass” effect through the liver.

Penetrates into the intercellular space, predominantly distributed in the liver, kidneys, lungs, and bronchial secretions.

Vd at equilibrium is 0.34 l/kg.

Rapidly deacetylated to cysteine ​​in the liver. In the plasma, a mobile equilibrium of free acetylcysteine ​​and its metabolites (cysteine, cystine, diacetylcystine) is observed, free and bound to plasma proteins.

T1 /2 is 2 hours. Acetylcysteine ​​and its metabolites are excreted mainly in the urine. The total clearance is 0.21 l/h/kg.

Respiratory diseases accompanied by the formation of high-viscosity sputum, including:

- acute and chronic bronchitis;

- atelectasis due to blockage of the bronchial tube with mucus;

— to remove viscous secretions from the respiratory tract in post-traumatic and postoperative conditions;

- to facilitate the passage of mucus during sinusitis.

The drug in the form of effervescent tablets is prescribed to adults at 600 mg (1 tablet) 1 time/day. Before use, the effervescent tablet is dissolved in 1/3 glass of water.

Granules for the preparation of a solution for oral administration are prescribed to adults and children over 6 years old - 200 mg 2-3 times a day; children aged 2 to 6 years - 200 mg 2 times / day or 100 mg 3 times / day; children aged 1 to 2 years - 100 mg 2 times a day.

In newborns and infants, the drug is used at a dose of 10 mg/kg body weight under the strict supervision of a physician.

Before use, the required amount of granules is dissolved in 1/3 glass of water. Children of the first year of life are given the resulting solution to drink from a spoon or feeding bottle.

The duration of the course of treatment is determined individually. For acute diseases, the duration of treatment is from 5 to 10 days, for chronic diseases - up to several months.

The injection solution can be administered parenterally, inhalation, or endobronchially.

Parenterally, adults are administered 300 mg (3 ml) deep IM or IV 1-2 times a day. Children aged 6 to 14 years are given 1/2 the adult dose. The daily dose for children under 6 years of age is 10 mg/kg body weight. The duration of the course of treatment is determined individually.

In the form of inhalations, the drug is prescribed to adults at a dose of 300 mg (3 ml) 1-2 times a day for 5-10 days or longer. For children, the drug is prescribed in the form of inhalations in the same dose.

The drug is administered endobronchially using appropriate equipment in doses (3-6 ml) or more per day, depending on clinical indications.

From the digestive system: rarely - heartburn, nausea, vomiting, diarrhea, stomatitis.

Allergic reactions: rarely - skin rash, itching, urticaria, bronchospasm.

Other: rarely - nosebleeds, tinnitus, collapse, decreased platelet aggregation.

Local reactions: with parenteral use, a slight burning sensation at the injection site is possible; when used by inhalation - reflex cough, local irritation of the respiratory tract, stomatitis, rhinitis; rarely - bronchospasm (in this case it is necessary to prescribe bronchodilators).

- peptic ulcer of the stomach and duodenum in the acute phase;

- hypersensitivity to acetylcysteine.

The drug in the form of effervescent tablets is not prescribed to children and adolescents under the age of 18 years.

During pregnancy and lactation, the use of Fluimucil is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or infant.

The drug should be prescribed with caution to patients with a predisposition to pulmonary hemorrhage and hemoptysis, and with diseases of the liver, kidneys, and adrenal glands.

For patients with bronchial asthma and obstructive bronchitis, Fluimucil can be prescribed only if adequate sputum drainage is ensured.

Oral dosage forms contain aspartame and should not be administered to patients with phenylketonuria.

When dissolving the drug, you must use glass containers and avoid contact with metal and rubber surfaces. When opening a package of granules, there may be a smell of sulfur, which is the smell of the active substance, and not evidence of poor quality of the drug.

Fluimucil, when taken at a dose of 500 mg/kg/day, does not cause signs and symptoms of overdose.

The simultaneous use of Fluimucil with antitussives may increase sputum stagnation due to suppression of the cough reflex.

When used simultaneously with antibiotics such as tetracyclines (excluding doxycycline), ampicillin, amphotericin B, they may interact with the thiol SH group of acetylcysteine, which leads to a decrease in the activity of both drugs, therefore the interval between taking acetylcysteine ​​and antibiotics should be at least 2 hours .

The simultaneous use of Fluimucil and nitroglycerin can lead to an increase in the vasodilatory and antiplatelet effects of the latter.

Acetylcysteine ​​reduces the hepatotoxic effect of paracetamol.

Effervescent tablets and granules are approved for use as over-the-counter products. The solution for injection is available with a prescription.

The drug should be stored in a dry place, out of reach of children, at room temperature no higher than 25°C. The shelf life of effervescent tablets and granules is 3 years, solution for injection is 5 years.

An opened ampoule of injection solution can be stored in the refrigerator for 24 hours. Using the drug from a previously opened ampoule is prohibited.

Source: http://docvita.ru/Details/FLUIMUCIL.html

Fluimucil

Instructions for use:

Prices in online pharmacies:

Fluimucil is an expectorant mucolytic drug.

Release form and composition

Dosage forms of Fluimucil:

  • oral solution: 20 mg/ml – transparent or slightly opalescent, colorless, with a characteristic raspberry odor and a slight sulfuric odor; 40 mg/ml – transparent, colorless or slightly yellow, with a characteristic odor of pomegranate and strawberries and a faint sulfuric odor (in dark glass bottles of 100, 150 or 200 ml, 1 bottle in a cardboard box);
  • solution for injection and inhalation: transparent, colorless, with a slight sulfuric odor; with prolonged contact with air after opening the ampoule, a slight pink-violet tint may appear (in dark glass ampoules of 3 ml, 5 ampoules in contour plastic packages, 1 package in a cardboard box);
  • granules for preparing a solution for oral administration: white-yellow with orange inclusions, have a characteristic orange, slightly sulfurous odor (1 g in multi-layer laminated bags, 20 or 60 bags in a cardboard box);
  • effervescent tablets: round, white, have a rough surface and a lemony, slightly sulfuric odor; the solution after reconstitution in water should be somewhat opalescent, have a characteristic smell and taste of lemon flavor (2 or 10 tablets in strip packs, 1, 2, 5 or 10 packs in a cardboard box).

Composition of 1 ml oral solution:

  • active substance: acetylcysteine ​​– 20 or 40 mg;
  • auxiliary components (20/40 mg): methyl parahydroxybenzoate – 1/1.8 mg; sodium benzoate – 1.5/0 mg; edetate disodium – 1/1 mg; carmellose sodium – 4/4 mg; sodium saccharinate – 0.4/0.4 mg; propyl parahydroxybenzoate – 0/0.2 g; 70% sorbitol – 0/120 mg; raspberry flavor – 2.5/0 mg; strawberry flavor – 0/10 mg; pomegranate flavor – 0/2 mg; sodium hydroxide – up to pH 6.5/6.5; purified water – up to 1/1 ml.

Composition of 1 ampoule of solution for injection and inhalation:

  • active substance: acetylcysteine ​​– 300 mg;
  • auxiliary components: sodium hydroxide – up to pH 6.5 (about 74 mg); edetate disodium – 3 mg; water for injection – up to 3 ml.

Composition of 1 sachet for oral solution:

  • active substance: acetylcysteine ​​– 200 mg;
  • auxiliary components: sorbitol – 662.7 mg; aspartame – 25 mg; orange flavor – 100 mg; betacarotene – 12.3 mg.

Composition of 1 effervescent tablet:

  • active substance: acetylcysteine ​​– 600 mg;
  • auxiliary components: sodium bicarbonate – 500 mg; aspartame – 20 mg; citric acid – 680 mg; lemon flavor – 100 mg.

Indications for use

  • impaired sputum discharge associated with blockage of the bronchi by a mucus plug, in diseases such as pulmonary atelectasis, pneumonia, bronchitis, bronchiolitis, tracheitis, cystic fibrosis, bronchiectasis, lung abscess, laryngotracheitis, pulmonary emphysema, interstitial lung diseases;
  • otitis (purulent and catarrhal), sinusitis, sinusitis (to facilitate the discharge of secretions);
  • viscous secretion in the respiratory tract during postoperative/post-traumatic conditions (for removal).

Additional indications for Fluimucil solution for injection and inhalation:

  • preparation for bronchoscopy, bronchography, aspiration drainage;
  • treatment of fistulas, the surgical field during operations on the mastoid process and the nasal cavity;
  • washing the middle ear, nasal passages, abscesses, maxillary sinuses.

Contraindications

  • exacerbation of peptic ulcer of the stomach and duodenum;
  • fructose intolerance (for oral solution 40 mg/ml);
  • age up to 2 years (for oral solution and granules for the preparation of oral solution), up to 6 years (for solution for injection and inhalation) and up to 18 years (for effervescent tablets);
  • lactation period;
  • individual intolerance to the components of the drug.

Relative (Fluimucil is prescribed with caution in the presence of the following diseases/conditions):

  • adrenal diseases;
  • pulmonary hemorrhage;
  • arterial hypertension;
  • peptic ulcer of the stomach and duodenum;
  • hemoptysis;
  • varicose veins of the esophagus;
  • bronchial asthma (for intravenous administration of Fluimucil solution for injection, since there is a high probability of bronchospasm);
  • renal/liver failure;
  • phenylketonuria (for granules for the preparation of oral solution and effervescent tablets; due to the presence of aspartame in the composition of the drug);
  • age up to 1 year (for intravenous administration of Fluimucil solution for injection, use of the drug is possible only in hospital settings in cases of vital indications);
  • pregnancy (the use of Fluimucil is possible only after assessing the ratio of benefits to possible risks).

Directions for use and dosage

Oral solution

Fluimucil is taken orally.

Recommended regimen for use of the drug (the daily dose of acetylcysteine ​​is indicated in parentheses):

  • children 2–5 years old: 2–3 times a day, 5 ml of a 20 mg/ml solution (200–300 mg);
  • children 6–14 years old: 3–4 times a day, 5 ml of a 20 mg/ml solution or 2 times a day, 4 ml of a 40 mg/ml solution (300–400 mg);
  • children over 14 years of age and adults: 15 ml of a 40 mg/ml solution (600 mg) once a day.

Maximum per day – 600 mg of acetylcysteine.

Solution for injection and inhalation

How to use Fluimucil:

  • parenterally: route of administration – intramuscular and intravenous (preferably drip or slow stream over 5 minutes); dosage regimen – 1–2 times a day, 3 ml (adults), 1–2 times a day, 1.5 ml (children 6–14 years old) or 10 mg/kg per day (children under 6 years old; it is preferable to prescribe the drug in oral forms; intravenous administration to children under 1 year of age is possible only if there are vital indications in a hospital setting);
  • inhalation (aerosol therapy): a 10% solution of 3–9 ml (in ultrasound devices) or 6 ml (in devices with a distribution valve) is used. The duration of inhalation is from 15 to 20 minutes, the frequency of use is 2–4 times a day. The average course duration for acute conditions is 5–10 days, for chronic conditions – up to 6 months. Depending on the therapeutic effect and the patient's condition, the doctor may make changes to the dosage regimen. For children, the drug is prescribed in adult doses. With a strong secretolytic effect, the secretion is sucked out, and the frequency of inhalations and the daily dose are reduced;
  • locally (instillation into the nasal passages and external auditory canal): 1.5–3 ml per 1 procedure;
  • intratracheal (during therapeutic bronchoscopy for washing the bronchial tree): 1–2 ampoules or more per day (depending on clinical indications).

The duration of the course is determined by the results of treatment. Fluimucil has high general and local tolerability, so its long-term use is possible.

Before intravenous administration, the solution should be further diluted with 5% dextrose solution or 0.9% NaCl solution (ratio 1:1).

For patients over 65 years of age, Fluimucil is usually prescribed in minimally effective doses.

Granules for the preparation of solution for oral administration

Fluimucil is taken orally, after dissolving a single dose in 1/3 glass of water.

Recommended dosage regimen:

  • newborns (only if there are vital indications and under medical supervision) and children under 1 year: 10 mg/kg (from a feeding bottle or spoon);
  • children 1–2 years old: 2 times a day, 100 mg;
  • children 2–6 years old: 3 times a day, 100 mg or 2 times a day, 200 mg;
  • children over 6 years old and adults: 2-3 times a day, 200 mg.

The duration of the therapeutic course is determined individually:

  • acute course of the disease: 5–10 days;
  • chronic course of the disease: up to several months.

Effervescent tablets

Fluimucil is taken orally (solution – 1 tablet in 1/3 glass of water).

Recommended dosage regimen for adults: 1 tablet once a day.

The duration of the therapeutic course is determined individually:

  • acute course of the disease: 5–10 days;
  • chronic course of the disease: up to several months.

Side effects

Oral solution, granules for solution, effervescent tablets

In rare cases, the development of the following adverse reactions may occur: nosebleeds, tinnitus, disorders of the digestive system (in the form of nausea, heartburn, feeling of fullness in the stomach, skin rash, vomiting, diarrhea), urticaria, itching.

There is also evidence of the development of collapse, bronchospasm, decreased platelet aggregation, and stomatitis.

Solution for injection and inhalation

  • inhalation administration: rhinorrhea, respiratory tract irritation, reflex cough; rarely – bronchospasm, stomatitis;
  • intramuscular administration: skin rash, burning at the injection site, urticaria; with long-term therapy – functional disorders of the kidneys/liver.

special instructions

For patients with bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

A light sulfuric odor is characteristic of the active substance Fluimucil.

The ampoule with solution for injection and inhalation must be opened before use. After opening, the drug can be used for 24 hours only for inhalation, provided it is stored in the refrigerator.

With shallow intramuscular injection of Fluimucil and in the presence of hypersensitivity, the development of a slight and quickly passing burning sensation may be observed, so it is recommended to inject the drug deep into the muscle.

Fluimucil solution (ready-made or obtained by dissolving tablets or granules) should not come into contact with metal/rubber surfaces.

Drug interactions

When Fluimucil is used in combination with certain drugs/substances, the following effects may develop:

  • antitussive drugs: increased stagnation of sputum, which is associated with suppression of the cough reflex;
  • antibacterial drugs - ampicillin, tetracyclines (except doxycycline), amphotericin B: decreased effectiveness of both drugs (recommended interval between doses is at least 2 hours);
  • nitroglycerin: enhancing its disaggregant and vasodilator effects;
  • paracetamol: eliminating its toxic effects.

Fluimucil solution is pharmaceutically incompatible with other drug solutions.

Terms and conditions of storage

Store at temperatures up to 25 °C. Keep away from children.

  • solution for oral administration – 2 years (after the first opening of the package – 15 days);
  • solution for injections and inhalations – 5 years;
  • granules for the preparation of solution for oral administration, effervescent tablets – 3 years.

Fluimucil tablets 600 mg 10 pcs.

Fluimucil 600 mg No. 10 effervescent tablets

Fluimucil tab. thorn. 600mg n10

Fluimucil granules 200 mg orange 20 pcs.

Fluimucil gran. d/r-ra internal 200mg n20 (orange)

Fluimucil granules 200 mg No. 20 sachets

Fluimucil powder 200 mg n20 packet

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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The well-known drug Viagra was originally developed for the treatment of arterial hypertension.

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The liver is the heaviest organ in our body. Its average weight is 1.5 kg.

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Source: http://www.neboleem.net/fluimucil.php

Fluimucil

Description current as of 05/16/2014

  • Latin name: Fluimucil
  • ATX code: R05CB01
  • Active ingredient: Acetylcysteine
  • Manufacturer: Zambon, Switzerland

Compound

1 tablet contains acetylcysteine ​​600 mg and additional substances: sodium bicarbonate, citric acid, lemon flavor, aspartame.

1 bag of granules contains acetylcysteine ​​200 mg, excipients: beta-carotene, aspartame, sorbitol, orange flavor.

1 ml of solution for inhalation and injection contains 100 mg of acetylcysteine, 1 ampoule contains 300 mg of acetylcysteine, additional substances: sodium hydroxide, disodium edetate, water.

Release form

Effervescent tablets, soluble in water, in blisters of 2 and 10 pcs.

Granules in multilayer bags, for dissolving in water and preparing a solution.

Solution in dark glass ampoules of 3 ml.

pharmachologic effect

Has a mucolytic effect. Acetylcysteine ​​breaks disulfide bonds in mucopolysaccharides of sputum, thereby ensuring its dilution and facilitating excretion. Even in the case of purulent sputum, it remains effective.

The drug prevents the adhesion of bacteria to the epithelium of the bronchial mucosa, stimulates cells that synthesize substances that break down fibrin threads. Acetylcysteine ​​has the same effect on the secretion of the mucous membranes of the upper respiratory tract.

The drug provides an antioxidant effect, has a cytoprotective effect and neutralizes toxins.

Acetylcysteine ​​has an anti-inflammatory effect due to its ability to suppress the formation of free radicals that cause inflammation in the lung tissue.

Pharmacodynamics and pharmacokinetics

After taking the drug, the maximum concentration in the blood occurs within 1-3 hours. Bioavailability is about 10%. Penetrates into the lungs, bronchial secretions, liver and kidneys; through the placenta.

It is excreted in the urine, the half-life is 1 hour, in case of liver cirrhosis it is 8 hours.

Indications for use

  • difficult sputum discharge due to respiratory pathology (laryngotracheitis, tracheitis, bronchitis, pneumonia, bronchiolitis, lung abscess, emphysema, cystic fibrosis, bronchiectasis, atelectasis, caused by obstruction of the bronchi with a mucus plug);
  • otitis, sinusitis (catarrhal and purulent);
  • facilitating the release of viscous secretions from the respiratory system (post-traumatic and postoperative conditions);
  • washing of the nasal passages, middle ear, maxillary sinuses, abscesses, fistulas, treatment of the intervention zone during operations on the mastoid process or nasal cavity;
  • preparation for aspiration drainage, bronchography, bronchoscopy.

Contraindications

  • exacerbation of stomach and duodenal ulcers;
  • individual intolerance to acetylcysteine;
  • breastfeeding period;
  • for granules - children under two years of age;
  • for effervescent tablets – children and adolescents under 18 years of age.

Children under 2 years of age are allowed to take a solution prepared from granules under the supervision of a doctor for health reasons.

For stomach ulcers, hemoptysis, bronchial asthma, arterial hypertension, pulmonary hemorrhage, phenylketonuria, renal and liver failure, varicose veins of the esophagus, use with caution.

Intravenous administration of the drug to children under 1 year of age is carried out for health reasons, under the supervision of a doctor.

Side effects

Digestive system: nausea, vomiting, heartburn, heaviness in the stomach, diarrhea.

Allergic reactions: cases of bronchospasm, urticaria, itching are possible.

Other symptoms may very rarely include: tinnitus, nosebleeds, collapse.

When used in the form of an aerosol: irritating effect on the respiratory tract, reflex cough, rhinorrhea, rarely - bronchospasm.

Intramuscular administration can lead to urticaria, burning at the injection site, and in case of long-term use, impaired renal and liver function.

Instructions for use of Fluimucil (Method and dosage)

For adults, effervescent tablets are used orally - 1 tablet (600 mg) per day once, pre-dissolved in a third of a glass of water.

The granules are used by both adults and children, dissolved in water (a third of a glass).

  • children over 6 years of age and adults – 600 mg per day in 3 divided doses;
  • for children under 200 mg twice daily;
  • 1 - 2 years - 100 mg twice a day.

For newborns, the drug is used under the supervision of a specialist in vital indications, observing a dose of 10 mg/kg of the child’s weight. Children in the first year of life are given syrup to drink from a spoon or bottle.

The average course of treatment is 5-10 days for acute cases, and several months for chronic cases.

For inhalation in physiotherapy, a 10% solution is used in an amount of 3-9 ml. Duration of inhalations is up to 20 minutes, 2 to 4 times a day.

If the drug is used during bronchoscopy for medicinal purposes, use 1-2 ampoules to wash the bronchi.

A dose of up to 300 mg is instilled into the external auditory canal at a time.

For use in rhinitis, there is a special form - nasal drops.

When administered intravenously (drip or slow stream) or intramuscularly, doses are determined as follows:

  • adults mg up to 2 times a day;
  • children 6-14 years old, 150 mg 2 times a day;
  • children under 6 years old - at the rate of 10 mg/kg.

Acetylcysteine ​​is administered to children under 1 year of age in hospital settings for health reasons.

The duration of treatment depends on the patient's condition.

When used for cough in children under 6 years of age, preference should be given to oral administration.

For intravenous administration, the drug is diluted with 0.9% sodium chloride solution in equal quantities. The duration of treatment in case of intravenous administration should not exceed 10 days.

In elderly patients, the instructions for Fluimucil indicate the need to use the minimum effective doses.

Overdose

Taking the drug in an amount of 0.5 g. per kg of body weight per day does not cause an overdose.

Interaction

Combined use with cough suppressants that suppress the cough reflex contributes to stagnation of sputum.

The use of tetracyclines (except doxycycline), amphotericin and ampicillin leads to a decrease in the effect of both antibiotics and acetylcysteine, so the break between taking these groups of drugs should be at least 2 hours.

The antiplatelet and vasodilating effect of nitroglycerin is enhanced when taken simultaneously with Fluimucil.

Pharmaceutically incompatible with other medicinal solutions.

Terms of sale

Over the counter - tablets and granules.

According to the recipe - solution.

Storage conditions

Keep away from children, storage temperature no more than 25°C.

Best before date

special instructions

Fluimucil is prescribed to patients with bronchial asthma and obstructive bronchitis with caution and under constant monitoring of bronchial patency.

It is not recommended for use in patients with phenylketonuria, since the drug contains aspartame.

For dissolution, use only glass containers and avoid contact with rubber and metal surfaces.

The smell of sulfur that appears when opening a bag of granules is a normal odor characteristic of the active substance.

Analogs

Fluimucil or ACC - which is better?

Both drugs contain the same active ingredient. They differ only in manufacturer and price, and even then only slightly. For example, 6 sachets of ACC with a dose of 600 mg cost 127 rubles, and Fluimucil costs 10 tablets. 174 rub. Therefore, the buyer must decide for himself which drug to choose.

For children

Use according to indications according to the instructions for the drug.

During pregnancy and lactation

If there is a need to use a medicine during pregnancy, you need to evaluate the balance of benefit to the mother and risk to the fetus.

During breastfeeding, if there is a need to use the drug, feeding should be stopped.

Reviews of Fluimucil

Fluimucil is quite popular for use against coughs. Numerous reviews are usually positive. There are good results from use against cough - Fluimucil is quite effective in both adults and children. On forums for young mothers, when asked to recommend a good cough syrup, many people remember Fluimucil. Perhaps the only drawback of using the drug is the formation of a large amount of sputum.

Nasal drops are also popular - there are many positive reviews when used in case of rhinitis.

Fluimucil price, where to buy

In Russia, the average price of Fluimucil tablets is 200 rubles. In Moscow, a package of 10 tablets with a dose of 600 mg costs 174 rubles, and granules can be bought for 186 rubles. for 20 packages.

  • Online pharmacies in Russia Russia
  • Online pharmacies in Ukraine Ukraine
  • Online pharmacies in Kazakhstan Kazakhstan

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Source: http://medside.ru/fluimutsil