Antibiotic "Fluimucil" - instructions for use and reviews
A universal combined drug that has an antimicrobial effect and thins sputum is the antibiotic Fluimucil.
Table of contents:
- Antibiotic "Fluimucil" - instructions for use and reviews
- Description of the drug
- Mechanism of action
- Indications
- Scope of use
- Method of use
- A course of treatment
- Contraindications
- Side effects
- Patient reviews
- Preparation of the solution
- Interaction with other drugs
- Shelf life and storage conditions
- Fluimucil nasal drops - an effective treatment for nasal diseases
- Release form
- Composition and effects
- Indications and contraindications
- Instructions and dosage
- Side effects
- Fluimucil antibiotic IT - an alternative to systemic antibiotics for sinusitis
- Composition of Fluimucil-antibiotic IT
- How does the medicine work?
- Thiamphenicol
- Acetylcysteine
- Fluimucil and Fluimucil antibiotic: what is the difference?
- Inhalation of Fluimucil antibiotic IT: detailed instructions
- Requirements for the inhaler
- Preparation for inhalation
- Preparation of Fluimucil antibiotic solution
- Procedure
- A course of treatment
- Antibiotic: apply topically
- Side effects of inhaled Fluimucil antibiotic IT
- When is the medicine contraindicated?
- Fluimucil antibiotic and other drugs: interaction
- Fluimucil antibiotic IT
- Pharmacological group
- Composition, release form
- pharmachologic effect
- Indications
- Contraindications
- Application
- Inhalations
- Intramuscularly
- Local use
- Reception features
- During pregnancy
- Side effects
- Drug overdose
- Storage
- Vacation conditions
- Use of Fluimucil for sinusitis
- One name – different properties
- Why are they effective for sinusitis?
- For what diseases can it be used?
- Features of application
- Inhalation therapy
- Advantages of inhalation with Fluimucil-antibiotic IT for sinusitis
- Use in special patient groups
- Precautionary measures
- Fluimucil - IT antibiotic
- Compound
- Release form
- pharmachologic effect
- Pharmacodynamics and pharmacokinetics
- Indications for use
- Contraindications
- Side effects
- Instructions for use Fluimucil - IT antibiotic (Method and dosage)
- Overdose
- Interaction
- Terms of sale
- Storage conditions
- Best before date
- special instructions
- Analogs
- For children
- During pregnancy and lactation
- Reviews about Fluimucil – IT antibiotic
- Price Fluimucil – IT antibiotic, where to buy
It is produced in bottles that come complete with a solvent – water, intended for injection.
Description of the drug
The main active ingredient of the drug is thiamphenicol glycinate acetylcysteinate. The product “Fluimucil-antibiotic IT” looks like a white powder. It is packaged in bottles of 250 or 500 mg. Also included in the package is water for injection, 2 or 4 mg in each ampoule, depending on the dosage.
This drug is a combination product that simultaneously contains the antibiotic thiamphenicol in combination with the mucolytic acetylcysteine. The antibacterial effect is achieved due to the fact that the active substance is active against many bacteria, especially those that cause problems with the respiratory tract. Thus, it is prescribed in cases where the causative agents are gram-positive microorganisms such as Staphylococcus spp., Streptococcus pneumoniae, Listeria spp., Streptococcus pyogenes, Corynebacterium diphtheria, Str. faecalis, Clostridium spp. It also helps cope with the following gram-negative bacteria: Neisseria, Haemophilus influenza, Escherichia coli, Salmonella, Shigella spp., Brucella spp., Bordetella pert., Bacteroides spp, Yersinia pestis.
Mechanism of action
The high effectiveness of this broad-spectrum antibacterial agent is achieved due to the fact that thiamphenicol inhibits the synthesis of microbial cell walls. And acetylcysteine, in turn, breaks the bonds of mucoproteins. Thanks to this, the antibiotic “Fluimucil” helps liquefy sputum quickly and effectively, regardless of whether it was purulent or mucous. Moreover, the mucolytic helps thiamphenicol penetrate tissue more easily and destroy bacterial cells directly in the respiratory tract, which speeds up recovery.
The maximum concentration of the antibiotic is observed 15 minutes after it was administered intramuscularly. It accumulates directly in the tissues of the respiratory tract. The drug "Fluimucil-antibiotic IT" is metabolized in the liver and excreted in the urine and in small quantities in feces.
Indications
It is necessary to use any antibacterial agents only after the appointment of a specialist. The drug “Fluimucil” (antibiotic) is no exception. Instructions for use contain information about when it can be prescribed. But patients should read it for informational purposes only, and not try to engage in therapy on their own.
It is prescribed to treat many respiratory diseases. But do not forget that it will be effective only in cases where the disease is caused by bacteria that are sensitive to thiamphenicol, and is accompanied by difficulties with sputum discharge.
Scope of use
The antibiotic "Fluimucil" can be prescribed for the following otolaryngological problems: laryngotracheitis, sinusitis, catarrhal otitis, infectious and obstructive complications of tracheostomy. It is also used in preparation for bronchoscopy.
It is often prescribed for the treatment of bronchitis, long-term pneumonia, and lung abscess. Bronchiectasis, emphysema and cystic fibrosis are also diseases for which the drug “Fluimucil-antibiotic IT” is recommended. Reviews indicate that the results of treatment appear almost the next day. The condition improves significantly after just 3-4 days. By the way, it can also be prescribed to children.
This drug is also used in surgery. The need for it arises after a series of thoracic surgical interventions, which may result in bronchopneumonia or atelectasis.
Phthisiatricians can use it in cases where pulmonary tuberculosis is accompanied by nonspecific forms of bronchial catarrh, with delayed discharge resulting from insufficient drainage.
Method of use
Many people mistakenly believe that there is only one way to use Fluimucil (an antibiotic). The instructions for use offer several options. In addition to intramuscular administration, its solution is used for inhalation, rinsing cavities, and even for application to problem areas.
If we are talking about injections, then for adults and adolescents over 12 years of age it is prescribed in a dosage of 500 mg and can be administered intramuscularly up to 3 times a day. Children over 7 years old are recommended to take 250 mg three times, and from 3 to 7 years old - in the same dosage, only 2 times a day. Children under 2 years of age are given injections of 125 mg twice a day.
If the doctor recommended the drug “Fluimucil-antibiotic IT” for inhalation, then it is important to understand that a single dose for adults cannot exceed 250 mg. And for children, 125 mg will be enough. You can do such inhalations 1 or 2 times a day.
It can also be infused intratracheobronchially through an installed permanent probe or during bronchoscopy. They can be used to wash the sinuses, treat the eardrum and other areas during surgical interventions. Sometimes doctors recommend dripping it into the nose or ears.
For rinsing, use 500 mg of the drug for adults and 250 for children. For instillation into the ears and nose, 2-4 drops of the prepared solution are enough.
A course of treatment
If necessary, the doctor can double the dosage of the drug intended for intramuscular administration. This is not recommended only in cases where newborns, premature babies and people over 65 years of age are treated using Fluimucil (an antibiotic). Feedback from patients suggests that doctors rarely resort to such excess dosages.
Contraindications
Despite the fact that this broad-spectrum antibiotic can be administered even to children who are not yet two years old, it is not prescribed to everyone. It cannot be used for leukopenia and anemia. If the patient has a history of thrombocytopenia, then it is also contraindicated.
Hypersensitivity to components, lactation and pregnancy are also included in the list of situations when it is better not to use this drug. Severe disturbances in the functioning of the kidneys or liver also impose restrictions.
Side effects
In rare cases, the use of an antibacterial agent may cause complications. Side effects include possible bronchospasm and allergic reactions. In cases where intramuscular administration is prescribed, disturbances in hematopoietic functions are also possible. Anemia and reticulocytopenia may develop. Diseases such as thrombocytopenia and leukopenia occur very rarely.
If you use the drug "Fluimucil" (antibiotic) for inhalation, the instructions warn that problems may also arise. Stomatitis or rhinitis may develop as a side effect. Some note that nausea occurs after inhalation.
Patient reviews
Many people note that the effect of using an antibiotic becomes noticeable literally the next day. It has an antimicrobial effect, thins mucus and promotes its removal. Fluimucil (an antibiotic) is often used for inhalation. Reviews confirm that to improve the condition it is not necessary to use only intramuscular administration. Inhalations with this drug can eliminate an obsessive cough and make it productive. The most optimal effect is achieved when using a nebulizer. This device ensures that particles of the product enter directly into the respiratory tract.
But you shouldn’t prescribe it yourself, without consulting a specialist. Only a doctor can determine whether you need to take an antibacterial agent in your case. The doctor must also choose the method of its use.
Preparation of the solution
If you have been prescribed intramuscular administration of the drug, then the water for injection included in the kit will be useful. It is used to dissolve dry powder. It is necessary to use 1 ampoule of water for each bottle. If you have been prescribed a one-time injection of not 500 mg, but a smaller amount, then you should not think that you need to look for another way to dilute Fluimucil. The antibiotic, prepared in the form of a solution, can be easily divided. If you need 250 mg, then simply put half of the total amount into the syringe, and to get 125 mg - ¼ part.
If you need to inhale, you can store the diluted powder in the refrigerator. By the way, for this purpose it can be dissolved not in water for injection, but in saline solution.
Interaction with other drugs
If you have been prescribed the antibiotic Fluimucil, you should consult your doctor before taking other medications. For example, the use of antitussives simultaneously with this drug can cause sputum stagnation due to the fact that the cough reflex will be blocked.
It is also important to know that acetylcysten reduces the hepatotoxic effect of drugs that contain paracetamol. And the simultaneous use of the drug “Fluimucil” with antibiotics such as “Ampicillin”, “Tetracycline”, “Amphotericin” causes the active effect of both drugs to decrease. Therefore, there should be an interval of at least 2 hours between their use.
The combination of the antibiotic "Fluimucil" and the drug "Nitroglycerin" leads to an increase in the antiplatelet and vasodilatory effects of the latter.
Shelf life and storage conditions
The drug in closed bottles at a temperature not exceeding 25 o C can be stored for up to 5 years, counting from the date of release. But the prepared injection solution can be kept in the refrigerator for no more than 24 hours. After the specified time has expired, it is no longer recommended to use it.
If you dilute the bottle and use it only for inhalation, then it can be stored in a cold place for 2 days. You can also store a solution prepared for instillation into the ears or nose.
Source: http://www.syl.ru/article/171802/new_antibiotik-fluimutsil—instruktsiya-po-primeneniyu-i-otzyivyi
Fluimucil nasal drops - an effective treatment for nasal diseases
This drug will help in a short time to cope with the manifestations of inflammation in various pathologies. The composition of the drops, indications for their use, as well as instructions for use will be discussed below.
Release form
The drug is available in the form:
- granules A solution is prepared from them, intended for oral administration. Sold in cardboard packages containing 20 or 60 bags of granules;
- effervescent tablets. A solution for oral administration is also prepared from them. A cardboard pack contains 10 or 20 tablets;
Composition and effects
1 ampoule of Fluimucil drops contains 300 mg of acetylcysteine. As additional components: water, sodium hydroxide, disodium edetate.
Acetylcysteine helps to liquefy and remove fluid from the nasal cavity. Thanks to this, the removal of pathogenic bacteria is accelerated, which contributes to a speedy recovery.
In addition, Fluimucil nasal spray has an antioxidant effect. The drug reduces lipid oxidation processes, blocks toxins and free radicals.
Fluimucil drops have the following therapeutic effects:
- anti-inflammatory;
- relieving swelling of the nasal mucosa;
- constriction of blood vessels, which reduces the release of fluid from the lumen of blood vessels into the nasal cavity.
Indications and contraindications
Fluimucil nasal drops are indicated for respiratory tract pathologies. The product will also help in case of excessively viscous secretion, which is difficult to discharge from the cavity. The medicine is also effective in cases of prolonged illness. Fluimucil for the nose is indicated for the following conditions:
The product is indicated for use in children over 3 years of age. In infants, drops are used on the recommendation of a specialist and under his supervision.
The instructions for use of Fluimucil state that the drug is contraindicated in the following conditions:
- discharge from the nasal cavity with blood;
- glaucoma;
- pregnancy and lactation;
- high sensitivity to the components of the drug;
- insufficiency of liver and kidney function;
- gastrointestinal ulcer in the acute stage;
- bronchial asthma;
- pulmonary hemorrhage.
Instructions and dosage
The instructions for Fluimucil nasal drops contain the following methods of use:
- if the patient is over 12 years old, then the product is instilled into the nose up to 4 times a day, 3 drops in each nostril;
- Children under 12 years of age can use no more than two drops in each nostril three times a day.
The medicine should not be used for more than 1 week. If treatment needs to be extended, you should consult your doctor.
To wash the sinuses and other cavities, you need to prepare a solution. To do this, mix 500 mg of Fluimucil powder in 4 ml of water for injection. For patients under 12 years of age, the amount of powder should be reduced to 250 mg. For rinsing you will need 1-2 ml of the prepared solution.
Side effects
The instructions for Fluimucil nasal drops list the following side effects:
- diarrhea;
- nose bleed;
- bronchospasm;
- allergic reactions;
- nausea and vomiting;
- heartburn;
- noise in ears;
- stomach discomfort;
- pressure drop;
- respiratory tract irritation;
- skin itching;
- cough;
- tachycardia;
- dry mucous membranes;
- hypertension;
- urinary retention;
- excessive nervous excitability.
All these adverse reactions can be avoided if you do not use the drug yourself without consulting your doctor.
Fluimucil nasal drops are an effective remedy that will quickly help eliminate both acute and chronic manifestations of nasal diseases. A variety of release forms allows the drug to be used both in the form of nasal drops and in the form of inhalations. Moreover, the medicine is quite safe. However, it is not recommended to use it on your own, since there are still contraindications and side effects. Therefore, before use, you should consult your doctor and use the drug only in accordance with the instructions.
Author: Vladislava Spiridonova, specialist,
Source: http://moylor.ru/lekarstva/kapli-v-nos/fluimucil/
Fluimucil antibiotic IT - an alternative to systemic antibiotics for sinusitis
Antibiotics for bacterial sinusitis are a necessity that must be accepted. However, along with oral (tablet) and injectable drugs, the inhaled antibiotic Fluimucil IT is used to treat inflammatory processes in the maxillary sinuses. And it is an excellent alternative to systemic antibiotic therapy.
>> The site presents an extensive selection of medications for the treatment of sinusitis and other nasal diseases. Enjoy it for your health! <
Composition of Fluimucil-antibiotic IT
Fluimucil-antibiotic IT is a combination drug that includes a complex complex called thiamphenicol glycinate acetylcysteinate. This substance, after absorption in the gastrointestinal tract, is split into two independent active drugs - acetylcysteine and thiamphenicol.
Fluimucil antibiotic IT is produced by a single manufacturer - the Italian company Zambon - and the medicine has no analogues.
The original medicine is produced in the form of a powder, from which the final solution is prepared using the solvent supplied with the package (ordinary water for injection).
How does the medicine work?
The combined active ingredient included in the IT antibiotic Fluimucil also provides a complex effect. At the same time, thiamphenicol and acetylcysteine have multidirectional effects, ultimately giving excellent results.
Thiamphenicol
The main active component of Fluimucil-antibiotic IT is a broad-spectrum antibacterial drug - a derivative of the well-known Chloramphenicol (Levomycetin). Thiamphenicol blocks the synthesis of bacterial cell wall protein, and, therefore, prevents the proliferation of microorganisms. The spectrum of action includes many gram-positive and gram-negative bacteria, including:
- staphylococci;
- pneumoniae streptococcus;
- Streptococcus pyogenes;
- corynebacteria;
- clostridia;
- hemophilus influenzae;
- coli.
Thiamphenicol covers the spectrum of the most common microorganisms that cause acute sinusitis, with the exception of resistant strains of Staphylococcus aureus and Moraxella. A positive side of the drug is also its high activity: it is known that thiamphenicol is 3-5 times more active than its parent chloramphenicol (Levomycentin). In addition, thiamphenicol, unlike Levomycetin, never provokes aplastic anemia.
Thanks to the association of the antibiotic with the second component acetylcysteine, thiamphenicol is able to remain stable and not be destroyed. In its pure form, despite its undoubted advantages, thiamphenicol is not used.
Acetylcysteine
Acetylcysteine is a classic and very effective expectorant that breaks strong disulfide bonds in the molecule of mucopolysaccharides of sputum and nasal secretions and thereby reduces their viscosity. Goblet cells that synthesize mucus, under the influence of acetylcysteine, begin to produce sialomucins - substances with a less thick consistency. They “dilute” nasal secretions and help remove them from the sinuses.
In addition, Acetylcysteine reduces the ability of bacteria to “adhere” to the mucous membrane of the nasal cavity and maxillary sinuses and helps inhibit the proliferation of pathogens. Let us recall that it is precisely due to the active copying of pathogenic microbes inside the paranasal sinuses that acute bacterial sinusitis develops.
Fluimucil and Fluimucil antibiotic: what is the difference?
Separately, I would like to draw attention to a common question that causes confusion among many patients. Is there a difference between two drugs with almost the same names Fluimucil and Fluimucil-antibiotic IT?
It turns out that there is: in fact, these are two completely different medicines. Fluimucil is an Acetylcysteine preparation and is used for coughs in a wide variety of respiratory diseases accompanied by the release of thick tracheobronchial secretions. Fluimucil does not have any antibacterial activity and is not used as a means for nebulizer therapy. This axiom applies to all forms of release without exception, that is, to products with a dosage of Fluimucil 200 mg, 600 mg, in the form of powder packets and effervescent tablets.
Adding the word “antibiotic” to the name of the drug indicates that we are dealing with an antimicrobial drug - the same one that is so effective against bacterial infections of the respiratory tract and nasopharynx.
Inhalation of Fluimucil antibiotic IT: detailed instructions
The drug is intended for injection, local and inhalation treatment. For acute and chronic inflammation of the maxillary sinuses, Fluimucil antibiotic is usually used topically and in the form of inhalations.
Requirements for the inhaler
Inhalations with the IT antibiotic Fluimucil are best done using a nebulizer, and the drug is fully suitable in all respects for use in these devices.
It should be remembered that not all modern nebulizers can be used to nebulize antibiotics.
Thus, in ultrasonic inhalers, antibiotics are destroyed under the influence of ultra-high frequency waves. There is practically no data on whether the antibiotic sprayed using the mesh technology remains intact. Therefore, the possibility of using popular mesh inhalers for antibiotic therapy is still questionable. But compressor inhalers do not damage the antibiotic molecule.
Another important point that should be taken into account when inhaling the nasopharynx concerns the size of the resulting particles: it should approach 10 microns. Smaller particles simply do not settle in the nasal cavity. Taking this nuance into account, add one more requirement to the inhaler: it must have the option of installing particles. Compressor nebulizers fully comply with this condition.
Preparation for inhalation
Before the procedure, you need to make sure that nasal breathing is not difficult. If this is not the case, you need to instill vasoconstrictor drops and restore breathing. Inhalation is carried out in a calm state, preferably one to one and a half hours after eating. Pay attention to body temperature: it should be below 37.5°C.
Preparation of Fluimucil antibiotic solution
After making sure that your body is ready for inhalation, you can begin preparing the medicinal solution. How to properly dilute Fluimucil-antibiotic IT? To do this, you need to dilute one bottle of the drug with 4 milliliters of water for injection, which comes with the medicine. A single adult dose of Fluimucil-antibiotic IT for inhalation according to the instructions for use is 250 mg of the active substance, and for children - 125 mg.
This is exactly half the recommended dosage for injection treatment. Reducing the drug load became possible due to the fact that during inhalation administration, the maximum concentration of the active substance is created in the affected area (in this case, in the nasopharynx and maxillary sinuses). It is approximately two times higher than with injection.
Based on the recommended single dose, it is necessary to calculate the volume of Fluimucil solution, which is poured into the nebulizer.
Remember that the device never completely uses up the medicine - some of it still remains on the walls of the nebulizer. Typically, the residual volume varies between 0.5–1.5 ml and depends on the specific model.
Read the instructions for your inhaler carefully and, having decided on the remaining volume, begin dosing Fluimucil IT antibiotic.
The dosage of the drug for adults is two milliliters of dissolved medication. Add the remaining volume of your device to this figure and measure this amount from the resulting Fluimucil antibiotic solution. The children's dosage is only 1 ml of the prepared solution. Increase the volume of medicine by the remaining volume of your device and carry out the procedure.
I would like to draw your attention to the fact that excessive dilution of the IT antibiotic Fluimucil in order to increase its volume is extremely undesirable. The medicine, as we have already found out, is not completely consumed - part of it remains in the chamber of the device. When the concentration in the residual solution is artificially reduced, the dosage of the drug is reduced. Consequently, in the “working medicine” entering the body, the dose, on the contrary, will increase. Moreover, the more the medicine is diluted, the more the active substance Fluimucil-antibiotic IT will penetrate the mucous membrane of the nose and maxillary sinuses.
Fluimucil IT antibiotic solution should be used immediately after preparation. It is prohibited to store the dissolved medicine - the antibiotic is destroyed in water.
Procedure
An inhalation therapy session is simple and raises far fewer questions than preparing for it. When treating the nasopharynx, you need to both inhale and exhale air through the nose. Breathing should be smooth. The duration of the procedure is 10–15 minutes. The frequency of procedures may vary: depending on the severity of the disease, the doctor prescribes one or two inhalations per day
A course of treatment
The optimal course of treatment with the IT antibiotic Fluimucil should last 10 days. A regimen designed for a shorter course of antibiotic therapy may be ineffective or may promote the growth of resistant strains of bacteria. The use of the drug for longer than 10 days is contraindicated.
Antibiotic: apply topically
There is also the possibility of topical use of the IT antibiotic Fluimucil. It is injected into the paranasal sinuses in a hospital setting or used to rinse the nasal cavity and maxillary sinuses. The dosage of the drug in this case is higher than with inhalation treatment.
The pediatric dose is 250 mg of Fluimucil IT antibiotic, and the adult dose is 500 mg. To prepare the working solution, 4 ml of solvent is injected into the antibiotic ampoule. Adults will need the entire volume of the prepared medicine, and children will need exactly half, that is, 2 ml. However, we note that inhalation treatment with Fluimucil is an order of magnitude more effective, so the drug is used topically quite rarely.
Side effects of inhaled Fluimucil antibiotic IT
The inhalation route of administration is valued not only for its speed of action and the maximum effect of low dosages. Fluimucil antibiotic IT, injected into the inflammatory focus - in our case, the nasal cavity and maxillary sinuses - bypasses the gastrointestinal tract. Therefore, the antibacterial effect does not extend to normal intestinal flora. Patients who are treated with inhaled antibiotics do not risk getting antibiotic-associated diarrhea (in common parlance, diarrhea).
However, some adverse events are still possible with nebulizer therapy. Thus, inhalation administration of Fluimucil-antibiotic IT, according to the instructions for use, may be accompanied by:
Irritation of the back of the throat can lead to a coughing fit. To avoid this effect, you need to ensure that your breathing is even;
This symptom may manifest itself as a slight burning or raw feeling. Usually, the discomfort goes away on its own soon after the procedure and does not require additional therapy;
With pronounced individual sensitivity to the antibiotic, in rare cases, the development of an inflammatory process in the nasal mucosa is possible;
As a rule, this symptom appears very rarely when high doses of Fluimucil are prescribed for a long period of time;
Patients prone to developing bronchospasm may develop narrowing of the bronchi in response to the administration of Fluimucil antibiotic. In such cases, treatment is continued while taking bronchodilators - drugs that dilate the bronchi (Salbutamol, etc.).
When is the medicine contraindicated?
Inhalation administration of the IT antibiotic Fluimucil is contraindicated in case of hypersensitivity to the antibiotic. Simply put, the drug should not be used by people allergic to acetylcysteine or chloramphenicol derivatives (Levomycetin).
During pregnancy, a medicine is prescribed only when the benefit to the woman outweighs the potential risk of side effects in the child. Breastfeeding women should not use Fluimucil-antibiotic IT, even in inhalation form.
Fluimucil antibiotic and other drugs: interaction
When using Fluimucil IT antibiotic, it is important to remember a few simple rules that will ensure the safety of treatment and maximum effect.
Thus, during inhalation use, part of the antibiotic may enter the respiratory tract. It should be taken into account that Acetylcysteine has a pronounced mucolytic effect. If the patient, while being treated with the antibiotic Fluimucil IT, takes antitussives that have a central effect and suppress the cough reflex, then stagnation of sputum may increase. This threatens the development of inflammatory diseases of the respiratory tract.
In addition, those who like to prepare complex medicinal solutions for inhalation should take into account that Fluimucil-antibiotic IT is a complex substance. It can enter into unpredictable reactions with other components, so combining it is prohibited.
Fluimucil antibiotic IT is used for the treatment of acute sinusitis and in the treatment of chronic sinusitis, including persistent, recurrent course of the disease. It is also indicated for the treatment of postoperative patients. However, when using Fluimucil antibiotic, we must not forget that thiamphenicol is not effective for sinusitis caused by Moraxella. Namely, this bacterium causes inflammation of the maxillary sinuses in 34% of children.
It is easy to avoid unnecessary, or rather ineffective, antibiotic therapy - to do this, you just need to exclude self-medication with antibacterial agents and trust your doctor. And a good specialist knows exactly when and with what antibiotics sinusitis should be treated.
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Source: http://gaimoriti.ru/medicamenty/fluimucil-antibiotik-it.html
Fluimucil antibiotic IT
Fluimucil antibiotic IT instructions: for use.
Pharmacological group
Complex product with antibiotic and mucolytic properties.
Composition, release form
Fluimucil antibiotic is available in the form of a lyophilisate (powder).
The glass bottle contains 810 mg of the drug, including the antibiotic tianfenicol and acetylcysteine glycinate, of which thiamphenicolamg.
An additional component is disodium edetet. Distilled water, packaged in separate ampoules, is used as a solvent.
pharmachologic effect
The therapeutic effect of the complex drug Fluimucil antibiotic is due to thiamphenicol and acetylcysteine.
Thiamphenicol is an antibiotic active against staphylococci, streptococci, neisseria, Klebsiella spp., Haemophilus influenza.
Thiamphenicol is highly effective against bacteria that cause diseases of the respiratory system, ENT organs - frontal sinusitis, rhinitis, sinusitis.
The drug has a pronounced effect against infections of the respiratory system with viscous purulent discharge.
Helps with long-term pneumonia that cannot be treated with other antibiotics.
The activity of the drug is observed against Streptococcus pneumonia, Staphylococcus spp., Corynebacterium diphtheria, Listeria monocytogenes. Thiamphenicol acts on the pathogens of salmonellosis, shigellosis, whooping cough, brucellosis, and plague.
The mucolytic effect of acetylcysteine is manifested in liquefaction, reducing the viscosity of sputum and pus.
Fluimucil antibiotic is excreted by the kidneys, a small part of the compound is excreted through the gastrointestinal tract. The drug crosses the placenta during pregnancy.
Indications
- Diseases of the ENT organs - otitis media, sinusitis (sinusitis, ethmoiditis, frontal sinusitis, sphenoiditis), laryngotracheitis.
- Bronchitis, pneumonia, lung abscess, bronchiolitis, cystic fibrosis, whooping cough.
- Nonspecific respiratory, mycobacterial infections.
- Prevention of complications during operations on the bronchi, trachea, and lungs.
Contraindications
Fluimucil antibiotic IT is not prescribed for anemia, diseases of the hematopoietic system, liver or kidney diseases.
Do not use in case of individual intolerance.
Use with caution in patients with bronchial asthma due to the risk of increased bronchospasm.
Fluimucil antibiotic is used with caution in children under 2 years of age due to age-related development and kidney function.
In patients over 65 years of age, the level of leukocytes in the blood is monitored during treatment. If the number of leukocytes drops below normal – 4 thousand/cm3, the drug is discontinued.
Application
Fluimucil antibiotic IT is used for inhalation, intramuscular administration, washing of the paranasal sinuses, body cavities, and applications.
Inhalations
Inhalations with a nebulizer are recommended:
- adults – 1-2 times a day, 250 mg;
- children - up to 2 times a day, 125 mg.
According to patients, 3-4 inhalations with fluimucil IT antibiotic are enough to feel relief.
Intramuscularly
- Adults – 500 mg 3 times a day;
- children 7-12 years old – 250 mg 3 times a day;
- children 3-7 years old – 250 mg 2 times a day;
- children from 2 weeks to 3 years – 125 mg 2 times a day;
- infants up to 2 weeks - the daily dose is calculated based on 25 mg per 1 kg of weight.
In newborns and elderly people, the dosage is not increased. The course of treatment is 10 days.
Local use
Locally, the antibiotic is used to wash the paranasal sinuses and is instilled into the ears and nose for ENT diseases.
For instillation into the ear canal and nose, fluimucil antibiotic is diluted:
- adults – 500 mg of lyophilisate in 4 ml of distilled water from an ampoule;
- children – 250 mg of lyophilisate in 4 ml of water.
Place 4 drops into the nose or ear canal.
Reception features
Fluimucil antibiotic for inhalation is not taken simultaneously with cough suppressants. This causes stagnation of mucus. The drug is taken separately from other medications.
The prepared fluimucil antibiotic for inhalation should be protected from contact with metal and rubber objects; the drug is diluted in a glass container.
During pregnancy
Fluimucil antibiotic is prescribed during pregnancy in exceptional cases, only on the recommendation of a doctor. The drug is not recommended during lactation.
Side effects
Allergy is possible when taken. Inhalation of the antibiotic fluimucil can cause coughing and irritation of the bronchial mucosa. Nausea, rhinitis, and stomatitis are noted. In rare cases, bronchospasm is observed.
Intramuscular injections can cause a burning sensation at the injection site. With this method of using the drug, anemia and changes in the blood formula are observed, expressed in a decrease in the number of platelets, leukocytes, and neutrophils.
Drug overdose
Self-medication is unacceptable; the result of an overdose and uncontrolled use of the drug can be superinfections, increased side effects, and changes in one’s own bacterial microflora.
Storage
The drug is stored at a temperature of +15 o C ... +25 o C, shelf life - 3 years.
Vacation conditions
Sold in pharmacies with a prescription, the price of a package of fluimucil antibiotic is rubles.
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Inexpensive drops for runny nose
Treatment of laryngitis in adults at home
How and with what to treat a sore throat in a 2-year-old child
By self-medicating, you can waste time and harm your health!
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Source: http://loramed.ru/preparat/fluimutsil-antibiotik-it.html
Use of Fluimucil for sinusitis
Fluimucil is widely used for sinusitis. However, not everyone knows that the pharmaceutical company Zambon produces 2 drugs called Fluimucil that differ in composition.
One name – different properties
The first drug Fluimucil is a mucolytic agent whose active substance is acetylcysteine. It is available in several dosage forms: solution for inhalation and injection, effervescent tablets.
Acetylcysteine has expectorant, mucolytic and detoxifying properties. It thins viscous sputum and mucus, increases their volume and promotes removal from the body. The detoxifying effect is ensured by the substance’s ability to destroy oxidative electrophilic toxins.
The second drug is Fluimucil-antibiotic IT. It is produced in the form of a lyophilisate, from which solutions for inhalation or injection are prepared. The active component of the drug is a complex chemical called thiamphenicol glycinate acetylcysteinate. Once in the body, this substance breaks down into 2 active components - thiamphenicol and acetylcysteine.
Thiamphenicol is an antibiotic derived from chloramphenicol, better known as chloramphenicol. It is active against most gram-positive and gram-negative microbes, stopping their reproduction. This antibacterial substance is not produced in its pure form due to its chemical instability. The introduction of thiamphenicol into the composition of the drug expands its medicinal properties, allowing it to be used for bacterial diseases.
Why are they effective for sinusitis?
Sinusitis is almost always accompanied by the formation of thick mucus in the sinuses. It makes nasal breathing difficult, causes headaches and a feeling of pressure in the bridge of the nose, and is also an excellent environment for the development of pathogenic microflora.
To get rid of sinusitis, it is necessary to return the original sterility of the sinuses, and if there is mucus in them, this is impossible. Therefore, the treatment regimen for any form of this disease must include a mucolytic agent, which is Fluimucil. Fluimucil-antibiotic IT will also allow you to avoid systemic use of antibacterial agents in the initial stages of purulent sinusitis.
For what diseases can it be used?
Both drugs can be used to treat respiratory diseases accompanied by impaired sputum production. Such diseases and conditions include:
- bronchitis;
- sinusitis;
- pneumonia;
- sinusitis;
- cystic fibrosis;
- whooping cough;
- emphysema;
- postoperative and post-traumatic conditions.
In addition, medications are prescribed for otitis and laryngitis, are used to prepare for examinations of the respiratory tract and are used to rinse the nasal passages, abscesses, etc.
Fluimucil antibiotic IT, in addition to the above cases, can be used to prevent and treat complications of thoracic surgical interventions, as well as infectious complications of tracheostomy.
Features of application
The type of drug and its method of use are prescribed only by the attending physician, depending on the disease and the severity of its course.
- During use, do not allow the drug to come into contact with rubber or metal surfaces.
- It is forbidden to take antitussives at the same time.
- The drug for inhalation is pharmaceutically incompatible with other solutions.
- You should strictly adhere to the recommended doses and application characteristics.
Inhalation therapy
Fluimucil for sinusitis is most often used in the form of inhalation. To carry it out, you will need a compression nebulizer, since an ultrasonic inhaler can destroy medicinal substances.
Before inhalation, the nebulizer is disinfected. Then prepare a solution of the drug Fluimucil-antibiotic IT by mixing the lyophilisate and solvent. Next, measure out the required dose of medication using a syringe and transfer it to the inhaler reservoir. The prepared solution cannot be stored, since the active substance is quickly destroyed and does not have a therapeutic effect.
If Fluimucil solution is used, then the required amount is immediately placed in the reservoir. An open ampoule with solution can be stored for 24 hours and used only for inhalation.
Before the procedure begins, the nasal passages are cleared of mucus using saline drops or sprays. Flushing the sinuses helps the medicine reach the site of inflammation. Inhalation is carried out using nasal attachments. Its duration usually ranges from 3 to 7 minutes. The course of therapy is no more than 10 days.
Advantages of inhalation with Fluimucil-antibiotic IT for sinusitis
Fluimucil antibiotic IT has a number of advantages when used for inhalation:
- The drug contains both an antibiotic and a mucolytic. This allows you to use substances from different groups simultaneously, which often require intervals of at least 2 hours between doses.
- During inhalation using a nebulizer, medicinal substances penetrate into the paranasal sinuses much better than when using sprays or steam inhalations.
- The maximum content of active substances is achieved directly at the site of inflammation.
- Local application helps prevent systemic effects on the body and minimize the possibility of side effects.
Use in special patient groups
Inhalation of the drug is prohibited in children under 2 years of age due to the age-related characteristics of the kidneys. Up to 6 years of age, take special care when treating with the drug. Fluimucil in the form of effervescent tablets is contraindicated under 18 years of age.
During pregnancy, the use of medications is allowed only in exceptional cases, when the benefit to the mother’s body is undeniably higher than the possible negative effect on the fetus.
During treatment, it is necessary to interrupt breastfeeding due to the ability of the drugs to pass into breast milk.
For the treatment of elderly patients, minimal therapeutic doses should be used.
The medicine is prescribed with extreme caution for disorders of the liver and kidneys.
Precautionary measures
Treatment with the drug should be discontinued if:
- hypersensitivity to any of the components of the drug;
- anemia;
- peptic ulcer of the stomach and duodenum;
- thrombocytopenia;
- leukopenia.
The use of these medications may be accompanied by side effects during inhalation therapy:
- reflex cough;
- inflammation and irritation of mucous membranes;
- stomatitis;
- nausea;
- bronchospasm.
Source: http://gaimorit-sl.ru/preparaty/mestno/fluimutsil-pri-gaimorite.html
Fluimucil - IT antibiotic
Description current as of 05/16/2014
- Latin name: Fluimucil – antibiotic IT
- ATX code: J01BA02
- Active ingredient: Thiamphenicol glycinas acetylcysteinas (Thiamphenicol glycinas acetylcysteinas)
- Manufacturer: Zambon, Italy
Compound
One bottle contains: glycinate acetylcysteinate thiamphenicol – 0.81 g, including thiamphenicol 500 mg; additional substance – disodium edetate; water as a solvent.
Release form
Powder obtained by lyophilization, from which a solution is prepared; in bottles complete with solvent, 3 pcs. in a pack.
pharmachologic effect
The substance is a combination of an antibiotic and a mucolytic drug.
Thiamphenicol has a wide spectrum of action on bacteria that cause respiratory tract infections - both gram-positive (streptococci, clostridia, staphylococci) and gram-negative (neisseria, Haemophilus influenzae, salmonella, yersinia, E. coli).
Acetylcysteine actively dilutes sputum and purulent discharge, promotes sputum discharge, reducing viscosity.
Acetylcysteine promotes better penetration of thiamphenicol into the lung tissue and prevents the adhesion of microorganisms to the mucous membrane of the respiratory system.
Pharmacodynamics and pharmacokinetics
Thiamphenicol accumulates in the respiratory tract, and maximum concentration occurs within 1 hour after injection into the muscle. The half-life is 3 hours, excreted in the urine.
Acetylcysteine accumulates in the intercellular space, bronchial secretions, lung tissue, liver and kidneys. Half-life – 2 hours; excreted by the kidneys, and a small part through the intestines.
The drug penetrates the placenta.
Indications for use
- damage to the ENT organs and upper respiratory tract (sinusitis, otitis, laryngotracheitis);
- diseases of the lower respiratory system (bronchitis, lung abscess, pneumonia, bronchiectasis, cystic fibrosis, emphysema, whooping cough, bronchiolitis);
- treatment and prevention of infectious and obstructive complications after tracheostomy, thoracic surgery (atelectasis, bronchopneumonia);
- preparation for aspiration of bronchial secretions and bronchoscopy;
- in order to improve drainage in case of concomitant pulmonary infections (including tuberculosis, the presence of cavernous lesions).
Contraindications
- diseases and changes in blood count (leukopenia, anemia, thrombocytopenia);
- individual intolerance to substances included in the drug.
Kidney function in children of the first 2 years of life has features associated with age, therefore, in them, as well as in patients with severe damage to the liver and kidney functions, the drug must be used with caution.
Side effects
Allergic reactions.
When injected into a muscle, there may be a burning sensation at the injection site; rarely leukopenia, thrombocytopenia, anemia, neutropenia, reticulocytopenia.
Using the antibiotic Fluimucil for inhalation can cause irritation of the respiratory mucosa, reflex cough, nausea, and rhinitis. Sometimes bronchospasm occurs, and bronchodilators should be used.
Instructions for use Fluimucil - IT antibiotic (Method and dosage)
Use intramuscularly in the dose:
- for adults, it is administered daily in 3 doses;
- children under three years of age 125 mg twice daily;
- children from 3 to 7 years mg twice a day;
- for children: 750 mg per day, divided into 3 injections.
For newborns up to 2 weeks, as well as premature infants, use a dose of 25 mg/kg body weight per day.
How to dilute for inhalation?
For adults, 500 mg of dry substance is dissolved in 4 ml of water for injection and divided into 2 doses per day (2 ml each). Inhalations for children are prepared in the same amount of water for injection as for adults (4 ml), dissolving 250 mg of powder and also used twice a day.
For otitis and diseases of the nasopharynx, 2-4 drops are instilled into the nasal passage or ear canal.
In case of appropriate indications, the dose of the drug can be doubled.
In newborns, premature and elderly patients, do not increase the dose.
The instructions for the antibiotic determine the course of treatment with the drug for no more than 10 days.
Overdose
Possible increased side effects of the drug, superinfection, disturbances of the bacterial flora. Symptomatic therapy is used as treatment.
Interaction
If you use cough suppressants, mucus stagnation may occur.
It is not recommended to mix the inhalation antibiotic Fluimucil with other substances in an aerosol.
Terms of sale
Storage conditions
Away from children and at temperatures between 15 and 25°C.
Best before date
special instructions
During the treatment period, constant monitoring of the blood count is necessary. If the number of granulocytes and leukocytes decreases, the drug should be discontinued.
Avoid contact of the solution with rubber and metal surfaces.
Analogs
It has no analogues.
For children
Use with great caution in children under two years of age, due to age-related characteristics of kidney function.
During pregnancy and lactation
Prescribe only when the benefit to the woman outweighs the risk to the fetus. During breastfeeding, if treatment is necessary, feeding should be stopped.
Reviews about Fluimucil – IT antibiotic
On many medical forums, there are reviews about Fluimucil, an antibiotic, usually from young mothers who used this antibiotic for inhalation for children. They note a quick effect - literally within 3-4 days the child’s condition improves. Those who have tried the drug at least once prefer it when they get sick again. It is very good to use the drug for a nebulizer - both convenient and effective.
Price Fluimucil – IT antibiotic, where to buy
In Russia, the price of Fluimucil-antibiotic IT ranges from 413 to 605 rubles.
The average price of Fluimucil for inhalation in Moscow is about 538 rubles. In Ukraine, the drug can be purchased for 174 UAH.
Hello! The doctor prescribed the child inhalations with the antibiotic fluimucil, but did not describe in what proportions. Do I need to add saline and if so, how much? The child is almost 3 years old. Cough and sore nasopharynx. Thank you in advance.
Fluimucil is an antibiotic. It greatly irritates the respiratory tract. My throat breaks after it. My throat hurts and stings from it. And my nose too. I don’t know if I still need it. For now I try it once a day. I seem to have bronchitis in the acute phase. Sputum. green. .but now it’s not like that anymore. A little lighter.
715 RUR bought on March 30, 2016 in a pharmacy next to Alpha Bank on the lands of Lipetsk
She was treating bronchitis (against the background of bronchial asthma). On the second day, a good effect from the inhalations was already noticeable. Great: fast, high quality, affordable.
My son is three years old, and his ENT doctor prescribed inhalations as follows: we dilute one injection bottle of water with 500 mg of powder. Then pour 3 ml of saline solution and 1 ml of the resulting solution into the inhaler. We inhale for 10 minutes, twice a day. One diluted ampoule is enough for 2 days. Store in the refrigerator. We are treated for six days. Snot and cough go away.
There is 500 mg of powder in a bottle, 4 ml of water in an ampoule - this is a dose for an adult for 2 doses. I have a question. Is it possible to dilute 500 mg in 8 ml of water and use it in 4 doses for a child? If possible, where and for how long should the solution be stored? In a refrigerator? And how to avoid contact of the solution with metal and rubber if you draw the solution with a syringe with a NEEDLE and the stopper of the bottle is RUBBER. Thank you.
I have asthma, COPD, emphysema. The doctor prescribed Fluimucil antibiotic inhalation through a nebulizer. During inhalation, severe suffocation occurred. Should I continue doing inhalations?
please tell me, my husband has sinusitis, but it bothers him when he is sick, but otherwise, can fluimucil-antibiotic IT help? Thanks in advance)
The drug helped us. We did inhalations for 5 days.
Alice, please tell me how old your child is, and in what proportion the antibiotic fluimucil should be diluted for inhalation. We were also prescribed it, our daughter has obstructive bronchitis, but I didn’t understand how to dilute it, with the water in the box or with saline solution. Thanks for the answer.
I would really like to say a big thank you to the manufacturers of fluimucil-antibiotic, as this is the second time it has saved a child from bronchitis. There is no need to take a bunch of pills, we breathed through a nebulizer 2 times a day for 10 minutes, and on the third day my daughter stopped choking on coughing. Now if we have a lingering cough, we only breathe with it))))
Konstantin: What I liked about the drug Prostanorm: reasonable price, pronounced effect of taking it.
Valentina: I, too, am all about diet and exercise. I hoped for loads, I thought that my healthy lifestyle.
Nina: I was on pills for a year and a half, then somehow everything calmed down. Mostly climatefit.
Elena: With the onset of menopause, the skin completely deteriorated and became dry. I saw a cream for .
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