Fluimucil antibiotic it for inhalation instructions price

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Fluimucil-antibiotic IT

Fluimucil-antibiotic IT: instructions for use and reviews

Latin name: Fluimucil-antibiotic IT

ATX code: J01BA02

Active ingredient: thiamphenicol glycinate acetylcysteinate

Table of contents:

Manufacturer: Zambon SPA (Italy)

Update of description and photo: 07/25/2017

Prices in pharmacies: from 664 rubles.

Fluimucil-antibiotic IT is a combined drug with antibacterial and mucolytic action.

Release form and composition

  • lyophilisate for the preparation of a solution for injection and inhalation: a plate-like mass of pale yellow or white color with a faint sulfuric odor (in a colorless glass bottle complete with solvent in an ampoule of 4 ml, 3 sets in a plastic tray, 1 tray in a cardboard box);
  • lyophilisate for the preparation of solution for injection (in a glass bottle complete with a solvent in an ampoule of 4 ml, in a blister pack, 3 sets, in a cardboard box, 1 pack; in an ampoule, in a blister pack, 3 ampoules, in a cardboard box, 1 pack).

Solvent (4 ml) – water for injection: colorless, transparent liquid, odorless and tasteless.

1 bottle of lyophilisate for the preparation of solution for injection/injection and inhalation contains:

  • active ingredient: thiamphenicol glycinate acetylcysteinate – 810 mg (which is equivalent to thiamphenicol in the amount of 500 mg);
  • additional component: disodium edetate – 2.5 mg.

Pharmacological properties

Pharmacodynamics

Thiamphenicol glycinate acetylcysteinate is a complex compound that includes the antibiotic thiamphenicol and the mucolytic acetylcysteine. After absorption, this compound is split into its constituent substances - thiamphenicol and acetylcysteine.

Thiamphenicol is part of the group of chloramphenicol derivatives; its mechanism of action is associated with inhibition of bacterial cell protein production. The substance is a broad-spectrum antibacterial drug. Thiamphenicol in vitro demonstrates effectiveness against bacteria that most often cause respiratory tract infections, both gram-positive (Corynebacterium diphtheriae, Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus spp., Clostridium spp., Listeria spp.) and gram-negative (Neisseria spp., Haemophilus influenzae, Escherichia coli, Salmonella spp., Bordetella pertussis, Shigella spp., Brucella spp., Yersinia pestis, Bacteroides spp.).

As a result of the rupture of disulfide bonds of mucoproteins, acetylcysteine ​​effectively and quickly dilutes sputum and pus, reduces their viscosity and facilitates discharge. Acetylcysteine ​​promotes the penetration of thiamphenicol into lung tissue and prevents the process of bacterial adhesion to the surface of the epithelium of the respiratory tract mucosa.

Pharmacokinetics

Thiamphenicol

Thiamphenicol is characterized by rapid distribution in the body and accumulation in therapeutic concentrations in the tissues of the respiratory tract. After intramuscular (IM) administration, the maximum concentration (Cmax ) is observed after 1 hour.

The binding of the substance to plasma proteins does not reach 20%. The half-life (T ½ ) is approximately 3 hours, the volume of distribution is 40–68 l. Excreted by the kidneys by glomerular filtration; one day after administration, the amount of unchanged substance in the urine can vary from 50 to 70% of the initially administered dose. Penetrates through the placental barrier.

Acetylcysteine

The substance is quickly distributed in the body, penetrating into the intercellular space, mainly accumulating in bronchial secretions, lungs, kidneys and liver. T ½ is 2 hours. During the deacetylation process in the liver, the drug is transformed into cysteine. It is characterized by a fluid balance in the blood of free and plasma protein-bound acetylcysteine, as well as the products of its metabolic transformation (diacetylcysteine, cystine and cysteine). In the form of inactive metabolites (diacetylcysteine, inorganic sulfates), the drug is excreted by the kidneys, and in small quantities unchanged through the intestines. The substance penetrates the placenta.

Indications for use

  • lesions of the lower respiratory tract: bronchitis in acute and chronic forms, prolonged pneumonia, emphysema, lung abscess, bronchiolitis, cystic fibrosis, bronchiectasis, whooping cough;
  • diseases of the ENT organs and upper respiratory tract: laryngotracheitis, sinusitis, exudative otitis media;
  • bronchopulmonary complications arising after thoracic surgical interventions (treatment and prevention): atelectasis, bronchopneumonia;
  • obstructive and infectious complications of tracheostomy (treatment and prevention);
  • concomitant nonspecific forms of respiratory infections, including cavernous lesions, mycobacterial infections (in order to improve drainage).

Fluimucil-antibiotic IT is also recommended for use in preparation for bronchoaspiration and bronchoscopy.

Contraindications

  • thrombocytopenia;
  • leukopenia;
  • anemia;
  • hypersensitivity to any of the components of the drug.

Relative (it is necessary to use Fluimucil-antibiotic IT with caution):

  • chronic renal failure;
  • liver failure;
  • age up to 2 years.

Instructions for use of Fluimucil-antibiotic IT: method and dosage

Fluimucil antibiotic IT is administered intramuscularly and used for inhalation, cavity rinsing, and applications.

Recommended dosage regimen depending on the route of administration of the drug:

  • endotracheally (through a tracheostomy, endotracheal tube, bronchoscope): 1–2 ml of solution once a day; for children, 250 mg of lyophilisate is diluted in 4 ml of the supplied solvent, for adults – 500 mg;
  • intranasally, instillation into the ears (for lesions of the nasopharynx and ear): inject 2-4 drops into each external auditory canal or nasal passage;
  • inhalation: 1–2 times a day for children 125 mg, adults – 250 mg;
  • washing of sinuses and cavities after surgical interventions in the area of ​​the mastoid process and nose: 1–2 ml of solution per 1 procedure; for children, 250 mg of lyophilisate is diluted in 4 ml of the supplied solvent, for adults – 500 mg;
  • IM: children under 3 years old – 125 mg 2 times a day; children from 3 to 7 years old – 2 times a day, 250 mg; children from 7 to 12 years old – 3 times a day, 250 mg; adolescents from 13 to 15 years old – 2 times a day, 500 mg; for adolescents over 15 years of age and adults – 2-3 times a day, 500 mg.

In newborns up to 14 days of life and premature infants, the average daily dose is 25 mg per 1 kg of body weight.

If necessary, in patients with severe disease in the first 2-3 days of the course, the dose may be increased by 2 times, with the exception of patients over 65 years of age, newborns and premature infants. The duration of therapy is no more than 10 days.

When using Fluimucil-antibiotic IT for inhalation, immediately before the procedure, it is necessary to remove the protective aluminum cap from the bottle with the lyophilisate and, having opened the ampoule with the solvent, inject the latter using a syringe into the closed bottle with the lyophilisate. After thoroughly mixing the contents of the bottle, take the recommended dose of the resulting solution with a syringe and pour it into the nebulizer (inhaler) reservoir. Inhalation is carried out for 5–10 minutes using a mask or nasal attachments.

The resulting solution of Fluimucil-antibiotic IT for inhalation can be stored for 24 hours at a temperature of 5 °C.

Side effects

During treatment with the drug, allergic reactions may develop.

When prescribing intramuscular administration of thiamphenicol glycinate acetylcysteinate, a slight burning sensation at the injection site may be observed, and rarely, leukopenia, anemia, reticulocytopenia, thrombocytopenia, neutropenia.

Inhalation administration of Fluimucil antibiotic IT can cause disorders such as local irritation of the respiratory tract, reflex cough, rhinitis, stomatitis, nausea. In some cases, bronchospasm develops, which requires the use of bronchodilators.

Overdose

Symptoms of a drug overdose may include superinfections, disruption of normal bacterial flora, and increased severity of side effects (except for allergic reactions).

If an overdose is suspected, maintenance therapy is prescribed.

special instructions

During the period of use of Fluimucil-antibiotic IT, it is necessary to monitor the peripheral blood picture. If there is a decrease in the number of leukocytes (less than 4000 in 1 μl) and granulocytes (more than 40%), therapy should be discontinued.

Contact of the solution with rubber and metal surfaces must be avoided.

For inhalation, it is recommended to use a compressor nebulizer, which should be adjusted so that the sprayed particles have a size of 3 to 20 microns. It is advisable to use a nebulizer made of plastic or glass. If some parts of the device are rubber or metal, they must be washed with water after use.

Impact on the ability to drive vehicles and complex mechanisms

According to the instructions, Fluimucil-antibiotic IT does not affect the ability to drive vehicles and other potentially dangerous and complex mechanisms.

Use during pregnancy and lactation

During pregnancy, the drug can be used only if the expected benefit of therapy for the mother significantly outweighs the possible risk to the fetus.

When using Fluimucil-antibiotic IT during lactation, it is recommended to stop breastfeeding.

Use in childhood

Children under 2 years of age should use the drug with extreme caution due to age-related differences in kidney function.

For impaired renal function

Patients with chronic renal failure should use the drug with extreme caution. In the presence of moderate and severe renal failure, it is recommended to treat separately with mucolytic and antibacterial agents, since it is necessary to reduce the dose of thiamphenicol.

For liver dysfunction

In the presence of liver failure, Fluimucil-antibiotic IT should be used with caution.

Use in old age

Elderly patients (over 65 years of age) are not recommended to increase the dose.

Drug interactions

The drug in aerosol form should not be mixed with other medications.

The combined use of Fluimucil-antibiotic IT with antitussive drugs can lead to stagnation of sputum due to suppression of the cough reflex.

Analogs

Fluimucil-antibiotic IT has no analogues for the active substance.

Terms and conditions of storage

Store out of the reach of children, at a temperature of 15–25 °C.

The shelf life of the kit is 3 years: lyophilisate – 3 years, solvent – ​​5 years (the shelf life of the kit is determined by the component with the shortest shelf life).

Conditions for dispensing from pharmacies

Dispensed by prescription.

Reviews of Fluimucil-antibiotic IT

Reviews about Fluimucil-antibiotic IT are in most cases positive. Patients who have used the drug note its effectiveness in the treatment of the respiratory tract and ENT organs in children and adults. A significant improvement in the condition, according to reviews, is noted already on the 3-4th day of therapy. Thanks to the mucolytic agent included in the antimicrobial drug, it intensively thins sputum and promotes its discharge.

The advantages of the drug also include the possibility of its use as a local antibiotic (in the form of inhalation), which reduces the risk of developing many side effects. Since the drug is an antimicrobial agent, it is recommended to use it only as prescribed by the attending physician.

The disadvantages of the product, many patients include its unpleasant taste and smell, especially pronounced during inhalation.

Price for Fluimucil-antibiotic IT in pharmacies

The price for Fluimucil-antibiotic IT can range from 650 to 930 rubles (a package containing 3 bottles of lyophilisate for injection, complete with 3 ampoules of solvent).

Fluimucil antibiotic IT lyophilisate 500 mg 3 pcs.

Fluimucil antibiotic etc. d/in. 500mg n3

Fluimucil-antibiotic IT lyophilisate for injection and inhalation 500 mg n3 fl with solvent

Fluimucil-antibiotic IT lyophilisate for solution 500 mg No. 3 bottles

Education: First Moscow State Medical University named after I.M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Source: http://www.neboleem.net/fluimucil-antibiotik-it.php

Fluimucil - IT antibiotic

Description current as of 05/16/2014

  • Latin name: Fluimucil – antibiotic IT
  • ATX code: J01BA02
  • Active ingredient: Thiamphenicol glycinas acetylcysteinas (Thiamphenicol glycinas acetylcysteinas)
  • Manufacturer: Zambon, Italy

Compound

One bottle contains: glycinate acetylcysteinate thiamphenicol – 0.81 g, including thiamphenicol 500 mg; additional substance – disodium edetate; water as a solvent.

Release form

Powder obtained by lyophilization, from which a solution is prepared; in bottles complete with solvent, 3 pcs. in a pack.

pharmachologic effect

The substance is a combination of an antibiotic and a mucolytic drug.

Thiamphenicol has a wide spectrum of action on bacteria that cause respiratory tract infections - both gram-positive (streptococci, clostridia, staphylococci) and gram-negative (neisseria, Haemophilus influenzae, salmonella, yersinia, E. coli).

Acetylcysteine ​​actively dilutes sputum and purulent discharge, promotes sputum discharge, reducing viscosity.

Acetylcysteine ​​promotes better penetration of thiamphenicol into the lung tissue and prevents the adhesion of microorganisms to the mucous membrane of the respiratory system.

Pharmacodynamics and pharmacokinetics

Thiamphenicol accumulates in the respiratory tract, and maximum concentration occurs within 1 hour after injection into the muscle. The half-life is 3 hours, excreted in the urine.

Acetylcysteine ​​accumulates in the intercellular space, bronchial secretions, lung tissue, liver and kidneys. Half-life – 2 hours; excreted by the kidneys, and a small part through the intestines.

The drug penetrates the placenta.

Indications for use

  • damage to the ENT organs and upper respiratory tract (sinusitis, otitis, laryngotracheitis);
  • diseases of the lower respiratory system (bronchitis, lung abscess, pneumonia, bronchiectasis, cystic fibrosis, emphysema, whooping cough, bronchiolitis);
  • treatment and prevention of infectious and obstructive complications after tracheostomy, thoracic surgery (atelectasis, bronchopneumonia);
  • preparation for aspiration of bronchial secretions and bronchoscopy;
  • in order to improve drainage in case of concomitant pulmonary infections (including tuberculosis, the presence of cavernous lesions).

Contraindications

  • diseases and changes in blood count (leukopenia, anemia, thrombocytopenia);
  • individual intolerance to substances included in the drug.
Kidney function in children of the first 2 years of life has features associated with age, therefore, in them, as well as in patients with severe damage to the liver and kidney functions, the drug must be used with caution.

Side effects

Allergic reactions.

When injected into a muscle, there may be a burning sensation at the injection site; rarely leukopenia, thrombocytopenia, anemia, neutropenia, reticulocytopenia.

Using the antibiotic Fluimucil for inhalation can cause irritation of the respiratory mucosa, reflex cough, nausea, and rhinitis. Sometimes bronchospasm occurs, and bronchodilators should be used.

Instructions for use Fluimucil - IT antibiotic (Method and dosage)

Use intramuscularly in the dose:

  • for adults, it is administered daily in 3 doses;
  • children under three years of age 125 mg twice daily;
  • children from 3 to 7 years mg twice a day;
  • for children: 750 mg per day, divided into 3 injections.

For newborns up to 2 weeks, as well as premature infants, use a dose of 25 mg/kg body weight per day.

How to dilute for inhalation?

For adults, 500 mg of dry substance is dissolved in 4 ml of water for injection and divided into 2 doses per day (2 ml each). Inhalations for children are prepared in the same amount of water for injection as for adults (4 ml), dissolving 250 mg of powder and also used twice a day.

Locally for washing the paranasal sinuses, incl. after surgical interventions, for endotracheal administration through a tracheostomy, bronchoscope or endotracheal tube, the powder is dissolved using water for injection in an amount of 4 ml, 500 mg for adults and 250 mg for children.

For otitis and diseases of the nasopharynx, 2-4 drops are instilled into the nasal passage or ear canal.

In case of appropriate indications, the dose of the drug can be doubled.

In newborns, premature and elderly patients, do not increase the dose.

The instructions for the antibiotic determine the course of treatment with the drug for no more than 10 days.

Overdose

Possible increased side effects of the drug, superinfection, disturbances of the bacterial flora. Symptomatic therapy is used as treatment.

Interaction

If you use cough suppressants, mucus stagnation may occur.

It is not recommended to mix the inhalation antibiotic Fluimucil with other substances in an aerosol.

Terms of sale

Storage conditions

Away from children and at temperatures between 15 and 25°C.

Best before date

special instructions

During the treatment period, constant monitoring of the blood count is necessary. If the number of granulocytes and leukocytes decreases, the drug should be discontinued.

Avoid contact of the solution with rubber and metal surfaces.

Analogs

It has no analogues.

For children

Use with great caution in children under two years of age, due to age-related characteristics of kidney function.

During pregnancy and lactation

Prescribe only when the benefit to the woman outweighs the risk to the fetus. During breastfeeding, if treatment is necessary, feeding should be stopped.

Reviews about Fluimucil – IT antibiotic

On many medical forums, there are reviews about Fluimucil, an antibiotic, usually from young mothers who used this antibiotic for inhalation for children. They note a quick effect - literally within 3-4 days the child’s condition improves. Those who have tried the drug at least once prefer it when they get sick again. It is very good to use the drug for a nebulizer - both convenient and effective.

Price Fluimucil – IT antibiotic, where to buy

In Russia, the price of Fluimucil-antibiotic IT ranges from 413 to 605 rubles.

The average price of Fluimucil for inhalation in Moscow is about 538 rubles. In Ukraine, the drug can be purchased for 174 UAH.

Hello! The doctor prescribed the child inhalations with the antibiotic fluimucil, but did not describe in what proportions. Do I need to add saline and if so, how much? The child is almost 3 years old. Cough and sore nasopharynx. Thank you in advance.

Fluimucil is an antibiotic. It greatly irritates the respiratory tract. My throat breaks after it. My throat hurts and stings from it. And my nose too. I don’t know if I still need it. For now I try it once a day. I seem to have bronchitis in the acute phase. Sputum. green. .but now it’s not like that anymore. A little lighter.

715 RUR bought on March 30, 2016 in a pharmacy next to Alpha Bank on the lands of Lipetsk

She was treating bronchitis (against the background of bronchial asthma). On the second day, a good effect from the inhalations was already noticeable. Great: fast, high quality, affordable.

My son is three years old, and his ENT doctor prescribed inhalations as follows: we dilute one injection bottle of water with 500 mg of powder. Then pour 3 ml of saline solution and 1 ml of the resulting solution into the inhaler. We inhale for 10 minutes, twice a day. One diluted ampoule is enough for 2 days. Store in the refrigerator. We are treated for six days. Snot and cough go away.

There is 500 mg of powder in a bottle, 4 ml of water in an ampoule - this is a dose for an adult for 2 doses. I have a question. Is it possible to dilute 500 mg in 8 ml of water and use it in 4 doses for a child? If possible, where and for how long should the solution be stored? In a refrigerator? And how to avoid contact of the solution with metal and rubber if you draw the solution with a syringe with a NEEDLE and the stopper of the bottle is RUBBER. Thank you.

I have asthma, COPD, emphysema. The doctor prescribed Fluimucil antibiotic inhalation through a nebulizer. During inhalation, severe suffocation occurred. Should I continue doing inhalations?

please tell me, my husband has sinusitis, but it bothers him when he is sick, but otherwise, can fluimucil-antibiotic IT help? Thanks in advance)

The drug helped us. We did inhalations for 5 days.

Alice, please tell me how old your child is, and in what proportion the antibiotic fluimucil should be diluted for inhalation. We were also prescribed it, our daughter has obstructive bronchitis, but I didn’t understand how to dilute it, with the water in the box or with saline solution. Thanks for the answer.

I would really like to say a big thank you to the manufacturers of fluimucil-antibiotic, as this is the second time it has saved a child from bronchitis. There is no need to take a bunch of pills, we breathed through a nebulizer 2 times a day for 10 minutes, and on the third day my daughter stopped choking on coughing. Now if we have a lingering cough, we only breathe with it))))

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Andrey: Not a word is said about choosing the size of stockings according to a person’s parameters: height, leg size, etc.

Olga: For coxarthrosis of the 2nd degree, I have been injecting for 4 years at the rate (after 6 months), there is no improvement.

All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

The site administration and the authors of the articles are not responsible for any losses and consequences that may arise when using the site materials.

Source: http://medside.ru/fluimutsil-antibiotik-it

Fluimucil-antibiotic IT

  • Zambon, Italy
  • Expiration date: until 01.11.2020

Fluimucil-antibiotic IT instructions for use

Buy with this product

Latin name

Release form

Lyophilized powder for the preparation of solution for injection

Compound

    1 bottle contains:
    Active ingredients: thiamphenicol glycinate acetylcysteinate 810 mg, disodium edetate

Package

pharmachologic effect

FLUIMUCIL ANTIBIOTIC is a mucolytic agent that thins sputum, increases its volume, and facilitates the separation of sputum. The action is associated with the ability of free sulfhydryl groups of acetylcysteine ​​to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolymerization of mucoproteins and a decrease in sputum viscosity (in some cases this leads to a significant increase in sputum volume, which requires aspiration of bronchial contents). Remains active against purulent sputum. Does not affect immunity. Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs. It has an antioxidant effect due to the presence of an SH group that can neutralize electrophilic oxidative toxins. Protects alpha1-antitrypsin (elastase inhibitor) from the inactivating effects of HOCl, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has some anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue).

Fluimucil-antibiotic IT, indications for use

Impaired sputum discharge: bronchitis, tracheitis, bronchiolitis, pneumonia, bronchiectasis, cystic fibrosis, lung abscess, emphysema, laryngotracheitis, bronchial asthma, pulmonary atelectasis (due to blockage of the bronchi by mucus plug). Catarrhal and purulent otitis media, sinusitis, sinusitis (facilitation of secretion discharge). Removal of viscous secretions from the respiratory tract in post-traumatic and postoperative conditions. Preparation for bronchoscopy, bronchography, aspiration drainage. For washing abscesses, nasal passages, maxillary sinuses, middle ear; treatment of fistulas, surgical field during operations on the nasal cavity and mastoid process.

Contraindications

Hypersensitivity, pregnancy, lactation period. With caution. Peptic ulcer of the stomach and duodenum (in the acute phase), varicose veins of the esophagus, hemoptysis, pulmonary hemorrhage, phenylketonuria (for forms containing aspartame), bronchial asthma (with intravenous administration there is a risk of developing bronchospasm), diseases of the adrenal glands, hepatic and/or renal failure, arterial hypertension.

Directions for use and doses

Adults - 300 mg 1-2 times a day. Children from 6 to 14 years old - 150 mg 1-2 times a day.

Use during pregnancy and breastfeeding

During pregnancy, the drug is prescribed only when the potential benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped during treatment.

Side effects

With intramuscular administration, a slight burning sensation at the injection site is possible, rarely - reticulocytopenia, anemia, leukopenia, neutropenia, thrombocytopenia.

With inhalation administration - reflex cough, local irritation of the respiratory tract, stomatitis, rhinitis, nausea. Bronchospasm is possible, in which case bronchodilators are prescribed.

special instructions

During treatment, peripheral blood patterns should be monitored. If the number of leukocytes (less than 4 thousand/μl) and granulocytes (by more than 40%) decreases, the drug is discontinued.

Fluimucil IT antibiotic solution should not come into contact with metal and rubber surfaces.

Fluimucil antibiotic IT does not affect the ability to drive vehicles and other mechanisms.

Drug interactions

The simultaneous administration of antitussives may increase sputum stagnation due to suppression of the cough reflex. It is not recommended to mix with other aerosol medications.

Check the interaction of other drugs with Fluimucil-Antibiotic IT

The drugs you have chosen

Overdose

Symptoms: changes in bacterial flora, superinfections. It is possible that the side effects of the drug may increase (with the exception of allergic reactions).

Maintenance therapy is recommended.

Storage conditions

At room temperature 15–25 °C.

Best before date

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Latest reviews about Fluimucil-antibiotic IT

As an ENT doctor I will say - the drug is super! In inhalations it easily copes with long-term exudative otitis media and rhinosinusitis. I would love to become their sales representative

We tried it for the first time, because there were no problems before! used in the form of inhalations and the effect appeared on the third day of use! the green sniffles disappeared and my nose began to breathe!

An excellent antimicrobial agent. Economical. Local action - a good effect when used in the form of inhalations.

Medicines in alphabetical order

** Delivery is carried out only for the preferential category of citizens on the basis of Art. 2 of the Federal Law of the Russian Federation of 01/09/1997 N 5-FZ “On the provision of social guarantees to heroes of socialist labor and full holders of the Order of Labor Glory” (as amended on 07/02/2013) and Article 1.1 of the RF Law of 01/15/1993 N “On the status of Heroes Soviet Union, Heroes of the Russian Federation and full holders of the Order of Glory." All orders are placed in a pharmacy (licensed) and collected by qualified pharmacists.

Source: http://www.piluli.ru/product/Fluimucil-antibiotik_IT

FLUIMUCIL-ANTIBIOTIC IT

Excipients: disodium edetate.

Solvent: water for injection (4 ml).

Bottles (3) complete with solvent (amp. 3 pcs.) - plastic pallets (1) - cardboard packs.

Thiamphenicol glycinate acetylcysteinate is a complex compound that combines the antibiotic thiamphenicol and the mucolytic acetylcysteine. After absorption of thiaminephenicol, glycinate acetylcysteinate is split into acetylcysteine ​​and thiamphenicol. Thiamphenicol is a derivative of chloramphenicol, the mechanism of action is associated with inhibition of bacterial cell protein synthesis. Thiamphenicol has a wide spectrum of antibacterial action and is effective in vitro against bacteria that most often cause respiratory tract infections: gram-positive (Streptococcus pneumoniae, Corynebacterium diphtheriae, Staphylococcus spp., Streptococcus pyogenes, Listeria spp., Clostridium spp.) and gram-negative (Haemophilus influenzae, Neisseria spp., Salmonella spp., Escherichia coli, Shigella spp., Bordetella pertussis, Yersinia pestis, Brucella spp., Bacteroides spp.).

Acetylcysteine, by breaking the disulfide bonds of mucoproteins, quickly and effectively dilutes sputum and pus, reduces their viscosity and promotes discharge. Acetylcysteine ​​facilitates the penetration of the antibiotic thiamphenicol into lung tissue and inhibits the adhesion of bacteria to the epithelium of the respiratory tract.

Thiamphenicol is rapidly distributed in the body and accumulates in the tissues of the respiratory tract in therapeutic concentrations. (tissue/plasma concentration ratio is about 1). Cmax is achieved 1 hour after intramuscular administration.

T1 /2 is about 3 hours, the volume of distribution is l. Plasma protein binding up to 20%. Excreted by the kidneys through glomerular filtration; 24 hours after administration, the amount of unchanged thiamphenicol in the urine is % of the administered dose. Penetrates through the placental barrier. Acetylcysteine ​​is quickly distributed in the body after use, T1 /2 is 2 hours.

In the liver it is deacetylated to cysteine. In the blood, a mobile equilibrium of free acetylcysteine ​​and its metabolites (cysteine, cystine, diacetylcysteine) is observed, free and bound to plasma proteins. Acetylcysteine ​​penetrates into the intercellular space and is predominantly distributed in the liver, kidneys, lungs, and bronchial secretions.

It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine), a small part is excreted unchanged through the intestines. Penetrates through the placental barrier.

- diseases of the upper respiratory tract and ENT organs: exudative otitis media, sinusitis, laryngotracheitis;

- diseases of the lower respiratory tract: acute and chronic bronchitis, prolonged pneumonia, lung abscess, emphysema, bronchiectasis, cystic fibrosis, bronchiolitis, whooping cough;

— prevention and treatment of bronchopulmonary complications after thoracic surgery (bronchopneumonia, atelectasis);

— prevention and treatment of obstructive and infectious complications of tracheostomy, preparation for bronchoscopy, bronchoaspiration;

— with concomitant nonspecific forms of respiratory infections to improve drainage, including cavernous lesions, with mycobacterial infections.

- hypersensitivity to one of the components of the drug.

With caution: with liver failure and chronic renal failure. In children of the first two years of life due to age-related characteristics of kidney function.

Fluimucil antibiotic IT is administered intramuscularly and used for inhalation, application, and cavity rinsing.

Inhalation: adults - 250 mg 1-2 times a day; children - 125 mg 1-2 times a day.

Endotracheal: through a bronchoscope, endotracheal tube, tracheostomy - 1-2 ml of solution (for adults, dissolve in 4 ml of water for injection, mg dry matter, for children, mg dry matter).

Locally: for administration into the paranasal sinuses, as well as for washing cavities after surgical interventions in the area of ​​the nose and mastoid process, 1-2 ml of solution (for adults, dissolve in 4 ml of water for injection, mg dry matter, for children, mg dry matter).

For diseases of the nasopharynx and ear, instill 2-4 drops into each nasal passage or external auditory canal.

Intramuscularly: adults - 500 mg 2-3 times a day; children under 3 years old - 125 mg 2 times a day; 3-7 years - 250 mg 2 times a day; 7-12 years - 250 mg 3 times a day.

For premature and newborn babies up to 2 weeks, the average dose is 25 mg/kg per day.

If necessary, the dose can be increased by 2 times (in the first 2-3 days of treatment in particularly severe cases). Do not increase the dose in premature and newborn children, as well as in patients over 65 years of age. The course of treatment is no more than 10 days.

With intramuscular administration, a slight burning sensation at the injection site is possible, rarely - reticulocytopenia, anemia, leukopenia, neutropenia, thrombocytopenia.

With inhalation administration - reflex cough, local irritation of the respiratory tract, stomatitis, rhinitis, nausea. Bronchospasm is possible, in which case bronchodilators are prescribed.

Symptoms: changes in bacterial flora, superinfections. It is possible that the side effects of the drug may increase (with the exception of allergic reactions).

Maintenance therapy is recommended.

The simultaneous administration of antitussives may increase sputum stagnation due to suppression of the cough reflex. It is not recommended to mix with other aerosol medications.

During treatment, peripheral blood patterns should be monitored. If the number of leukocytes (less than 4 thousand/μl) and granulocytes (by more than 40%) decreases, the drug is discontinued.

Fluimucil IT antibiotic solution should not come into contact with metal and rubber surfaces.

Fluimucil antibiotic IT does not affect the ability to drive vehicles and other mechanisms.

During pregnancy, the drug is prescribed only when the potential benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped during treatment.

With caution in case of liver failure.

At temperatures from 15°C to 25°C. Keep out of the reach of children.

Shelf life: lyophilisate for the preparation of solution for injection and inhalation 500 mg (bottles) - 3 years; solvent: water for injection (ampoules) - 5 years; set - 3 years.

Note: The expiration date of the kit is determined by the component with the shortest expiration date.

To ask a question about the project or contact the editors, use this form.

Source: http://health.mail.ru/drug/fluimucil_antibiotic_it/

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Source: http://www.eapteka.ru/goods/drugs/respiratory/sputum/fluimutsil/

Fluimucil-antibiotic IT: instructions for use

The drug Fluimucil IT is an antibiotic combined with a mucolytic and antioxidant.

Release form and dosage composition

Fluimucil antibiotic IT is available in the form of lyophysiate for the preparation of a solution for injections and inhalation use.

The drug is available in bottles complete with a solvent (3 units of each) in a cardboard box. The instructions indicate the rules for using the drug and a number of contraindications.

1 bottle of the drug contains the active substance - Thiamphenicol glycinate acetylcysteinate 810 mg and Thiamphenicol 500 mg, sodium editate acts as an auxiliary substance, and water for injection acts as a solvent.

Indications

The main indications for prescribing the IT antibiotic Fluimucil are the following conditions:

  • inflammatory diseases of the ENT organs and respiratory system - otitis media, sinusitis, laryngitis, tracheitis, laryngotracheitis;
  • inflammatory diseases of the upper and lower respiratory tract - bronchitis, including chronic, pneumonia, lung abscess, bronchiectasis, cystic fibrosis, emphysema;
  • pulmonary atelectasis;
  • prevention of bronchopulmonary complications in bedridden patients and patients who have recently undergone surgery on the chest organs.

The drug is prescribed to improve the discharge of sputum and dilute it. It is possible to use the drug when preparing a patient for bronchoscopy and bronchoaspiration.

Contraindications

Before starting therapy, the patient must undergo an examination to determine the cause of cough and sputum, and also carefully read the attached instructions. Fluimucil antibiotic IT is contraindicated for use in the presence of one or more conditions:

  • thrombocytopenia and leukopenia;
  • Iron-deficiency anemia;
  • individual intolerance to the components of the drug;
  • exacerbation of chronic erosive gastritis, gastric and duodenal ulcers;
  • breastfeeding period;
  • pregnancy 1st trimester;
  • age of children under 2 years;
  • treatment with drugs that inhibit the cough center.

Directions for use and dosage

The drug Fluimucil-Antibiotic IT is intended for intramuscular or inhalation use. According to the instructions, adult patients are prescribed 250 mg of the drug 2 times a day in the form of inhalation, children over 2 years of age are prescribed 125 mg 1-2 times a day by inhalation.

Intramuscularly, adults are prescribed 500 mg of the drug 2 times a day, children from 2 to 4 years old - 125 mg 2 times a day, children from 3 to 12 years old - 250 mg 2 times a day.

As a last resort, in case of urgent need, Fluimucil Antibiotic IT can be used to treat children from 2 weeks of age. In this case, the dose of the drug is calculated by the doctor strictly individually, based on body weight.

Elderly patients require individual adjustment of the minimum effective dose, since people over 65 years of age are much more likely to develop side effects than younger patients.

The total duration of the course of treatment should not exceed 10 days; if during this time no improvements are observed, then the patient should consult a doctor to adjust the therapy and clarify the diagnosis.

Use during pregnancy and lactation

In the 1st trimester of pregnancy, the use of the drug Fluimucil-Antibiotic IT is contraindicated for women, since therapy can negatively affect the process of formation of the child’s internal organs and cause congenital deformities.

In the 2nd and 3rd trimesters of pregnancy, the use of the drug is possible under the supervision of a physician, only in case of serious indications, when the expected benefit to the mother outweighs the possible risk to the fetus.

During lactation, the use of the drug Fluimucil Antibiotic IT is contraindicated, since the active components of lyophysiate can be excreted in breast milk and enter the child’s body. If therapy is necessary, the woman should stop breastfeeding.

Side effects

The drug Fluimucil Antibiotic IT is usually well tolerated by patients. Persons with hypersensitivity to the components of the drug may develop allergic reactions and bronchospasm, paroxysmal cough, rhinitis, lacrimation when using lyophysiate by inhalation.

When administering the prepared solution of the drug intramuscularly, the patient may experience local side effects:

  • pain at the injection site;
  • formation of a dense infiltrate;
  • hyperemia and swelling of the koi at the injection site;
  • rashes around the injection site.

Overdose

Cases of overdose with Fluimucil Antibiotic IT are extremely rare. With prolonged uncontrolled use of the drug in high doses, the patient may develop resistance of infectious agents to the components of the drug and the development of superinfection.

If signs of overdose develop, the patient is given supportive symptomatic therapy.

Interaction of the drug with other drugs

The drug Fluimucil Antibiotic IT cannot be prescribed simultaneously with antitussives and tablets that suppress the functioning of the cough center. This leads to congestion and blockage of the airways with mucus.

When using the drug by inhalation, it is not recommended to mix the drug with any other solutions for inhalation, as this may increase the risk of sudden bronchospasm and asphyxia in the patient.

special instructions

Lyophysiat Fluimucil antibiotic IT should be diluted with the supplied solvent immediately before use. Do not allow the drug solution to come into contact with metal surfaces, as this leads to the destruction of the components of the drug.

The drug Fluimucil IT antibiotic does not affect the functioning of the central nervous system and the speed of psychomotor reactions.

During drug therapy, blood counts should be monitored; if the level of platelets and leukocytes in the blood decreases, treatment should be stopped immediately and a doctor should be consulted.

Analogs

Fluimucil antibiotic IT has no analogues, so if you need to select another medicine, you should consult a doctor.

Conditions of release and storage

The drug Fluimucil IT antibiotic is dispensed from pharmacies with a doctor's prescription. Vials with lyophysiate should be stored in a cool, dark place out of the reach of children. The shelf life of the drug is 3 years from the date of manufacture; do not use the drug with an expired expiration date.

Fluimucil antibiotic IT price

In Moscow pharmacies, the average cost of Fluimucil antibiotic IT is from 550 rubles.

Source: http://bezboleznej.ru/fluimutsil-antibiotik-it

Fluimucil ® -antibiotic IT (Fluimucil ® -antibiotic IT)

Active substance:

Content

Pharmacological groups

Composition and release form

in glass bottles complete with solvent in ampoules of 4 ml; There are 3 sets in a cardboard pack.

pharmachologic effect

Directions for use and doses

A single dose for adults is 500 mg, for children - 250 mg.

Inhalations: 500 mg 1 time per day.

Endobronchial administration: 500 mg in 1–2 ml of water once a day.

Washing of cavities: from 250 mg to 500 mg per 1 procedure.

IM, adults - 500 mg 2-3 times a day, children: up to 2 years - 125 mg 2 times a day, 3-6 years - 250 mg 2 times a day, 7-12 years - 250 mg 3 times a day.

Storage conditions for the drug Fluimucil ® -antibiotic IT

Keep out of the reach of children.

Shelf life of the drug Fluimucil ® -antibiotic IT

Do not use after the expiration date stated on the package.

Prices in Moscow pharmacies

The information is intended solely for comparing prices in stationary pharmacies operating in accordance with Article 55 of the Federal Law “On the Circulation of Medicines” dated April 12, 2010 N 61-FZ.

lyophilisate for the preparation of solution for injection 500 mg, 3 pcs.

Zambon SPA (Italy)

lyophilisate for the preparation of solution for injection 500 mg, 3 pcs.

Zambon SPA (Italy)

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Opinion of “Doctors of the Russian Federation” about the drug Fluimucil ® - an IT antibiotic

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Fluimucil - IT antibiotic - official instructions for use

Registration number:

Trade name: Fluimucil ® -antibiotic IT

International nonproprietary (or generic) name. Thiamphenicol glycinate acetylcysteinate

Chemical name. 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-aminoacetyl oxymethyl-2-(4-methylsulfonylphenyl)ethyl] acetamide acetylcysteinate

Dosage form: lyophilisate for the preparation of solution for injection and inhalation.

1 bottle contains: the active substance thiamphenicol glycinate acetylcysteinate mg (in terms of thiamphenicol .mg) and the excipient disodium edetate. 1 ampoule of solvent: water for injection.

Contents of the bottle: White or light yellow plate-like mass with a slight sulfuric odor.

Ampoule contents: Transparent, colorless liquid, odorless and tasteless.

Pharmacotherapeutic group antibiotic combined (antibiotic + mucolytic)

Thiamphenicol glycinate acetylcysteinate is a complex compound that combines the antibiotic thiamphenicol and the mucolytic acetylcysteine. After absorption of thiaminephenicol, glycinate acetylcysteinate is split into acetylcysteine ​​and thiamphenicol. Thiamphenicol is a derivative of chloramphenicol, the mechanism of action is associated with inhibition of bacterial cell protein synthesis. Thiamphenicol has a wide spectrum of antibacterial action and is effective in vitro against bacteria that most often cause respiratory tract infections: gram-positive (Streptococcus pneumoniae, Corynebacterium diphtheriae, Staphylococcus spp., Streptococcus pyogenes, Listeria spp., Clostridium spp.) and gram-negative (Haemophilus influenzae, Neisseria spp., Salmonella spp., Escherichia coli, Shigella spp., Bordetella pertussis, Yersinia pestis, Brucella spp., Bacteroides spp.).

Acetylcysteine, by breaking the disulfide bonds of mucoproteins, quickly and effectively dilutes sputum and pus, reduces their viscosity and promotes discharge. Acetylcysteine ​​facilitates the penetration of the antibiotic thiamphenicol into lung tissue and inhibits the adhesion of bacteria to the epithelium of the respiratory tract.

Thiamphenicol is rapidly distributed in the body, accumulates in the tissues of the respiratory tract in therapeutic concentrations (tissue/plasma concentration ratio is about 1). Maximum plasma concentration is achieved 1 hour after intramuscular administration. The half-life is about 3 hours, the volume of distribution is liters. Plasma protein binding up to 20%. Excreted by the kidneys through glomerular filtration; 24 hours after administration, the amount of unchanged thiamphenicol in the urine is % of the administered dose. Penetrates through the placental barrier. Acetylcysteine ​​is quickly distributed in the body after use, the half-life is 2 hours. In the liver it is deacetylated to cysteine. In the blood, a mobile equilibrium of free acetylcysteine ​​and its metabolites (cysteine, cystine, diacetylcysteine) is observed, free and bound to plasma proteins. Acetylcysteine ​​penetrates into the intercellular space and is predominantly distributed in the liver, kidneys, lungs, and bronchial secretions. It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine), a small part is excreted unchanged through the intestines. Penetrates through the placental barrier.

Fluimucil antibiotic IT is used for the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug and accompanied by mucostasis.

Diseases of the upper respiratory tract and ENT organs: exudative otitis media, sinusitis, laryngotracheitis.

Diseases of the lower respiratory tract: acute and chronic bronchitis, prolonged pneumonia, lung abscess, emphysema, bronchiectasis, cystic fibrosis, bronchiolitis, whooping cough.

Prevention and treatment of bronchopulmonary complications after thoracic surgery (bronchopneumonia, atelectasis). Prevention and treatment of obstructive and infectious complications of tracheostomy, preparation for bronchoscopy, bronchoaspiration.

With concomitant nonspecific forms of respiratory infections to improve drainage, including cavernous lesions, with mycobacterial infections.

Hypersensitivity to one of the components of the drug; anemia, leukopenia, thrombocytopenia.

For liver failure and chronic renal failure. In children of the first two years of life due to age-related characteristics of kidney function.

Use during pregnancy and lactation

During pregnancy, the drug is prescribed only when the potential benefit to the mother outweighs the potential risk to the fetus. If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped during treatment.

Fluimucil antibiotic IT is administered intramuscularly and used for inhalation, application, and cavity rinsing.

Inhalation: adults - 250 mg 1-2 times a day; children - 125 mg 1-2 times a day.

Endotracheal: through a bronchoscope, endotracheal tube, tracheostomy - 1-2 ml of solution (for adults, dissolve in 4 ml of water for injection, mg of dry matter, for children, mg of dry matter).

Locally: for administration into the paranasal sinuses, as well as for washing cavities after surgical interventions in the area of ​​the nose and mastoid process, 1-2 ml of solution (for adults, dissolve in 4 ml of water for injection, mg dry matter, for children, mg dry matter).

For diseases of the nasopharynx and ear, instill 2-4 drops into each nasal passage or external auditory canal.

Intramuscularly: adults - 500 mg 2-3 times a day; children under 3 years old - 125 mg 2 times a day; 3-7 years - 250 mg 2 times a day; 7-12 years - 250 mg 3 times a day.

For premature and newborn babies up to 2 weeks, the average dose is 25 mg/kg per day.

If necessary, the dose can be increased by 2 times (in the first 2-3 days of treatment in particularly severe cases). Do not increase the dose in premature and newborn children, as well as in patients over 65 years of age.

The course of treatment is no more than 10 days.

With intramuscular administration, a slight burning sensation at the injection site is possible, rarely - reticulocytopenia, anemia, leukopenia, neutropenia, thrombocytopenia.

With inhalation administration - reflex cough, local irritation of the respiratory tract, stomatitis, rhinitis, nausea. Bronchospasm is possible, in which case bronchodilators are prescribed.

Symptoms: changes in bacterial flora, superinfections. It is possible that the side effects of the drug may increase (with the exception of allergic reactions). Maintenance therapy is recommended.

Interaction with other drugs

The simultaneous administration of antitussives may increase sputum stagnation due to suppression of the cough reflex. It is not recommended to mix with other aerosol medications.

During treatment, peripheral blood patterns should be monitored. If the number of leukocytes (less than 4 thousand/μl) and granulocytes (by more than 40%) decreases, the drug is discontinued.

Fluimucil ® antibiotic IT solution should not come into contact with metal and rubber surfaces. Fluimucil ® antibiotic IT does not affect the ability to drive vehicles and other mechanisms.

Lyophilisate for the preparation of solution for injection and inhalation 500 mg. 810.0 mg of lyophilisate for the preparation of a solution for injection and inhalation in colorless glass vials (type I), sealed with a chlorobutyl rubber stopper and an aluminum cap for rolling. 4.0 ml of water for injection in clear glass ampoules (type I).

3 bottles of lyophilisate complete with 3 ampoules of solvents in a plastic tray along with instructions for use in a cardboard pack.

At temperatures from 15 °C to 25 °C. Keep out of the reach of children.

Lyophilisate for the preparation of solution for injection and inhalation 500 mg (bottles) 3 years

Solvent: water for injection (ampoules) 5 years

Set 3 years

Note: The expiration date of the kit is determined by the component with the shortest expiration date.

Do not use after the expiration date stated on the packaging.

Zambon S.P.A., Italy 36100, Via della Quimica 9, Vicenza, Italy.

Claims regarding the quality of the drug should be sent to the following address: Representative office of JSC Zambon S.P.A. (Italy): Russia, Moscow, Glazovsky lane, 7, office 17.

Source: http://medi.ru/instrukciya/fluimutsil-antibiotik-it_3543/